Cov txiaj ntsig ntawm kev siv Captopril-AKOS hauv ntshav qab zib

Captopril-AKOS: cov lus qhia rau kev siv thiab tshuaj xyuas

Lub npe Latin: Captopril-AKOS

ATX Code: C09AA01

Tus nquag siv: captopril (Captopril)

Cov tsim tawm: Synthesis, Qhib Tib Neeg (Russia)

Kho cov lus piav qhia thiab daim duab: 11/30/2018

Cov nqi hauv khw muag tshuaj: los ntawm 10 rubles.

Captopril-AKOS yog ib qho kev tiv thaiv kabmob angiotensin-hloov pauv enzyme (ACE), ib qho kev tiv thaiv tshuaj tsis haum.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj: tiaj-cylindrical, nrog chamfer, yuav luag dawb lossis dawb, muaj cov yam ntxwv ntawm tus ntxhiab, lub teeb marbling raug tso cai, kev sib cais tsis sib haum yog siv rau cov ntsiav tshuaj ntawm kev noj tshuaj ntawm 50 mg (ntau npaum ntawm 25 mg: 10 lossis 25 pcs. , hauv pob ntawv los ntawm pob 1, 2, 3 lossis 4 pob, ntau npaum 50 mg: 10 lossis 20 pcs hauv cov hlwv, hauv ib pob ntawv hauv pob los ntawm 1, 2, 3, 4 lossis 5 pob, 10, 20, 30, 40 , 50, 60, 80 lossis 100 pcs. Hauv cov kaus poom yas, hauv ib daim npav card 1 tuaj yeem, txhua pob ntawv kuj muaj cov lus qhia hais txog kev siv ntawm captopril-ICCO).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: captopril (hauv qhov tseeb ntawm qhov hnyav qhuav) - 25 lossis 50 mg,
Lub cev ntu: ntau npaum li 25 mg - pob kws hmoov txhuv nplej siab, mis qab zib, magnesium stearate, talc, ntau npaum li 50 mg - lactose monohydrate (mis nyuj qab zib), colloidal silicon dioxide (aerosil), microcrystalline cellulose, crospovidone (CL-M collidone, CL collidone), magnesium stearate, talc.

Cov Tshuaj Hauv Tshuaj

Captopril-AKOS yog cov tshuaj tiv thaiv kev kub ntxhov, lub tshuab ntawm kev coj ua uas yog vim muaj cov yam ntxwv ntawm cov tshuaj nquag - captopril. Captopril yog thawj koob tshuaj ACE inhibitor muaj pawg SH (sulfhydryl pawg). Los ntawm inhibiting ACE, nws txo cov kev hloov pauv ntawm angiotensin I rau angiotensin II thiab tshem tawm nws cov vasoconstrictor ntxim rau cov leeg thiab cov hlab ntsha. Kev txo qis hauv qib ntawm angiotensin II txhawb kev nce ntxiv hauv kev ua si ntawm cov ntshav plasma renin, ua rau muaj kev txo qis ntawm kev zais ntawm aldosterone los ntawm adrenal cortex. Qhov no ua rau muaj kev txo qis rau txhua qhov kev tawm tsam mob ntshav khov (OPSS) thiab ntshav siab (BP), kev tawm tsam hauv cov hlab ntsws, thiab kev poob qis hauv kev ua ntej- thiab tom qab lub siab. Txhawb cov hlab plawv tso zis, ua kom ib ce muaj zog.

Nyob hauv kev cuam tshuam ntawm captopril, cov hlab ntsha nthuav dav mus rau ntau dua li cov leeg ntshav. Kuj, noj Captopril-AKOS ua rau kev nce prostaglandin synthesis thiab txo qis hauv kev ua kom zoo ntawm bradykinin.

Cov nyhuv anthypertensive ntawm captopril tsis yog nyob ntawm cov kev ua ntawm plasma renin. Nws cov txiaj ntsig ntawm cov nqaij mos renin-angiotensin-aldosterone system (RAAS) ua rau txo qis ntshav siab thaum lub cev ua haujlwm thiab cov tshuaj hormones tsawg dua.

Captopril txhim kho cov hlab ntshav siab thiab cov hlab ntsha khiav ntshav, txhim kho cov ntshav mus rau ischemic myocardium. Nws siv mus ntev ua rau txo qis ntawm qhov mob myocardial hypertrophy thiab cov phab ntsa ntawm cov hlab ntsha tiv thaiv kab mob, txwv tsis pub muaj kev txhim kho ntawm lub plawv tsis ua hauj lwm, thiab inhibits kev txhim kho ntawm sab laug ventricular dilatation.

Noj Captopril-AKOS ua rau txo qis platelet kev sib sau, hauv plawv tsis ua hauj lwm - kom txo qis hauv cov ntsiab lus ntawm sodium ions.

Txo cov tonus ntawm efferent arterioles ntawm glomeruli ntawm lub raum pab txhawm rau txhim kho intracubule hemodynamics thiab tiv thaiv qhov pom ntawm ntshav qab zib nephropathy.

Hauv ib koob tshuaj txhua hnub ntawm 50 mg, captopril ua pov thawj angioprotective cov khoom tiv thaiv cov hlab ntshav ntawm microvasculature. Hauv cov neeg mob uas mob nephroangiopathy mob ntshav qab zib, nws ua rau qhov qeeb qeeb ntawm qhov mob raum tsis ua haujlwm.

Tsis zoo li cov vasodilators ncaj qha, xws li hydralazine thiab minoxidil, txo qis ntshav siab thaum noj Captopril-AKOS tsis yog nrog los ntawm reflex tachycardia thiab pab txo myocardial oxygen xav tau. Siv cov tshuaj captopril ntau txaus hauv cov neeg mob lub plawv tsis cuam tshuam rau ntshav cov ntshav.

Tom qab lub qhov ncauj tswj hwm, qhov siab tshaj plaws nyob rau hauv cov ntshav tshwm sim hauv 1-1.5 teev. Lub sijhawm ntawm cov nyhuv hypotensive yog nyob ntawm cov koob tshuaj tau noj; nws nce mus txog nws qhov txiaj ntsig zoo tshaj plaws tom qab ntau lub lis piam ntawm kev kho.

Koj tsis tuaj yeem tshem tawm sai sai ntawm captopril, qhov no tuaj yeem ua rau nce ntshav ntxiv.

Cov Tshuaj Pharmacokinetics

Tom qab qhov ncauj tswj hwm, qhov kev nqus sai ntawm kwv yees li 75% ntawm koob tshuaj Captopril-AKOS tshwm sim. Kev noj zaub mov kom zoo ib txhij txo kev nqis peev captopril los ntawm 30-40%. Thaum lub sijhawm pib tso tawm los ntawm daim siab, 35-40% ntawm cov tshuaj nquag raug biotransformed. Kev siab tshaj plaws (C_max) hauv cov ntshav cov ntshav tau tiav hauv 0.5-1.5 teev thiab yog 114 ng / ml.

Kev khi rau cov ntshav plasma protein - 25-30% (feem ntau yog nrog albumin).

Tshaj dhau ntawm cov ntshav-hlwb thiab placental teeb meem hauv ib qho me me (tsawg dua 1%). Nrog rau niam cov kua mis, nce txog 0.002% ntawm qhov koob tshuaj tau noj yog muab zais cia.

Captopril yog metabolized hauv lub siab nrog kev tsim cov tshuaj pharmacologically tsis muaj zog metabolites - captopril disulfide dimer thiab captopril-cysteine sulfide.

Ib nrab-lub neej (T_1/2) captopril yog kwv yees li 2-3 teev. Kwv yees 95% ntawm cov koob tshuaj uas tau lees txais yog tawm los ntawm ob lub raum thaum thawj 24 teev (suav nrog 40-50% tsis hloov).

Hauv kev mob raum tsis ua haujlwm, cov tshuaj ntau zuj zus, T_1/2 tuaj yeem ncav cuag li 3.5 txog 32 teev. Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum txo qis ib koob thiab / lossis nce ntxiv ntu ntawm koob tshuaj Captopril-AKOS.

Kev ntsuas rau siv

arterial hypertension (suav nrog kev kho ntshav siab),
mob plawv tsis ua hauj lwm - ua ib feem ntawm cov kev kho mob nyuaj,
Kev ua haujlwm ntawm sab laug ventricle tom qab myocardial infarction hauv cov neeg mob hauv qhov chaw kho mob ruaj khov,
ntshav qab zib nephropathy nyob rau hauv hom 1 mob ntshav qab zib mellitus (albuminuria ntau dua 30 mg / hnub).

Cov Yuav Tsum Muaj

lub raum mob raum, ob tog hlaus raum leeg ntshav siab, raum ib lub raum stenosis nrog rau azotemia mob zuj zus, tso ntshav tawm tsis ua haujlwm, thawj hyperaldosteronism, mob tom qab hloov raum,
mob siab ua rau daim siab,
kev siv aliskiren thiab aliskiren-muaj cov neeg sawv cev hauv cov neeg mob uas muaj ntshav qab zib hom 2 ntshav qab zib los yog hauv cov neeg mob tsis zoo lub raum muaj nuj nqi nrog creatinine tshem tawm (CC) tsawg dua 60 ml / min,
lactose intolerance, qabzib-galactose malabsorption syndrome lossis lactase tsis txaus,
cev xeeb tub lub sijhawm
pub niam mis
hnub nyoog txog 18 xyoo
kev mob siab thiab / lossis idiopathic angioedema tiv thaiv keeb kwm ntawm kev kho mob yav dhau los nrog ACE inhibitors (suav nrog keeb kwm),
cov tshuaj tiv thaiv tsis haum rau lwm txoj ACE inhibitors, suav nrog keeb kwm
kev tsis qaug rau lub zog ntawm cov tshuaj.

Nrog kev ceev faj, Captopril-AKOS ntsiav tshuaj yuav tsum tau tsim tawm rau kev mob ntshav siab, mob plawv, mob raum tsis ua hauj lwm, mob ntshav qab zib tsis txaus, thiab hloov pauv zoo sib xws uas cuam tshuam cov ntshav tawm ntawm sab laug ventricle ntawm lub plawv, nyob rau hauv kev hloov kho mob ntshav siab, mob raum tsis ua haujlwm, mob hlwb lupus erythematosus, lossis lwm yam cov kab mob tiv thaiv cov nqaij mob, inhibition ntawm pob txha hlwb hematopoiesis, cerebrovascular pathologies, ntshav qab zib mellitus, hyperkalemia, tsis hnov qab lub siab ua haujlwm, kev noj zaub mov txwv ntawm sodium chloride, hemodialysis, raws plab, ntuav, lossis lwm yam ua rau muaj kev cuam tshuam ntawm cov ntshav ntau thaum lub sijhawm phais lossis dav dav rau tshuaj loog, hemodialysis siv high-flow membranes (suav nrog AN69 polyacrylonitrile high-flow membranes), concomitant desensitizing kho, apheresis uas tsis muaj lipoproteins tsawg (LDL), nrog rau cov diuretics potassium-sparing, cov tshuaj potassium, cov muaj potassium ntxiv thiab ntsev, lithium npaj, cov neeg mob ntawm cov haiv neeg Negroid, hauv cov laus.

Sab sij huam

Cov kev tsis txaus siab nyob rau ntawm cov kab ke thiab kabmob (raws li qhov muaj ntau zaus ntawm lawv txoj kev loj hlob, tau muab faib raws li hauv qab no: ntau heev - ≥ 1/10, feem ntau - ≥ 1/100 thiab 9 rau 1 liter coj kev kuaj ntshav dav dav, hauv qab no 1 x 10 9 rau 1 liter - tshuaj Yog tias pom muaj cov tsos mob sib kis, nrog rau mob caj pas lossis ua npaws, yuav tsum kuaj cov ntshav nrog tus leukocyte suav.

Nws yuav tsum tau yug los rau hauv lub siab tias kev noj Captopril-AKOS tiv thaiv keeb kwm ntawm kev kho mob sab nrauv nrog hymenoptera venom thiab cov zoo li ua rau muaj kev pheej hmoo ntawm anaphylactoid tshua.

Yog tias muaj kev ua haujlwm ntau ntawm hepatic transaminases lossis qhov tsos mob ntawm lub ntsej muag daj, kev kho nrog captopril yuav tsum tau txiav tawm tam sim ntawd.

Hauv cov tib neeg ntawm kev sib tw Negroid, ACE inhibitors, suav nrog Captopril-AKOS, ua rau pom tsawg dua qhov tawm suab los tiv thaiv kev tsis zoo.

Kev kuaj ntshav rau cov tshuaj acetone hauv cov neeg mob noj cov tshuaj tuaj yeem qhia qhov tsis zoo.

Cev xeeb tub thiab lactation

Kev siv Captopril-AKOS yog contraindicated thaum yoj tes thiab pub mis.

Cov poj niam ntawm lub hnub nyoog yug menyuam uas tab tom npaj kom cev xeeb tub yuav tsum zam qhov siv ACE inhibitors (suav nrog captopril). Lawv yuav tsum pom zoo rau lwm txoj kev kho antihypertensive.

Yog tias muaj kev xav tshwm sim thaum lub sijhawm tswj hwm ntawm Captopril-AKOS, yuav tsum tshem tawm sai sai thiab yuav tsum tau soj ntsuam kev loj hlob ntawm tus menyuam hauv plab. Kev siv ntawm captopril hauv thawj ib hlis thawj ntawm cev xeeb tub muaj feem ua rau muaj kev pheej hmoo ntawm kev tsim teeb meem hauv kev yug menyuam hauv plab. Kev siv lub sijhawm ntev ntawm cov tshuaj nyob rau hauv II thiab III trimesters yog cov tshuaj lom rau cov menyuam hauv plab thiab ua rau lub sijhawm qeeb ntawm ossification ntawm cov pob txha pob txha taub hau, txo qis raum kev ua haujlwm, oligohydramnios, nws raug nquahu kom soj ntsuam cov xwm txheej ntawm cov pob txha pob txha thiab lub raum kev ua haujlwm ntawm tus me nyuam los ntawm ultrasound (ultrasound).

Hauv cov menyuam yug tshiab uas lawv niam tau noj captopril ntev ntev hauv II thiab III trimesters ntawm cev xeeb tub, kev txhim kho ntawm lub cev tsis ua haujlwm ntawm lub raum tsis ua haujlwm, hyperkalemia, hypotension yog ua tau.

Nrog lub raum tsis ua haujlwm

Kev siv Captopril-AKOS rau kev kho mob ntawm cov neeg mob uas lub raum tsis zoo ntawm ob leeg lub raum mob raum, ob lub raum stenosis nrog mob azotemia, refractory hyperkalemia, thawj hyperaldosteronism, thiab qhov mob tom qab lub raum hloov raum yog contraindicated.

Nrog kev ceev faj, captopril yuav tsum tau kho rau cov neeg mob uas mob raum tsis ua haujlwm.

Nrog tus neeg ua hauj lwm tsawg ntawm lub raum ua haujlwm tsis zoo (CC 30 ml / min thiab siab dua), Captopril-AKOS tuaj yeem raug muab tshuaj rau ib hnub ib zaug ntawm 75-100 mg.

Nrog kev mob raum tsis zoo (CC tsawg dua 30 ml / min), qhov koob tshuaj txhua hnub yuav tsum tsis pub tshaj 12,5 mg. Yog tias tsim nyog, qhov koob tshuaj tuaj yeem raug nce siab zuj zus, soj ntsuam kev sib txuam lub sijhawm ntev, tab sis kev saib xyuas txij nkawm yuav tsum tsawg dua li cov koob tshuaj ib txwm siv los kho kev mob ntshav siab.

Tej zaum lub hom phiaj ntxiv ntawm "voj" diuretics, tab sis tsis yog diuretics ntawm thiazide koob.

Kev kho ntawm cov tshuaj ntau dua yog tias tsis ua haujlwm raum lub raum yuav tsum ua rau suav nrog tus neeg mob QC qhov taw qhia hauv qab raws li no:

CC 40 ml / min: thawj koob tshuaj txhua txhua hnub yog 25-50 mg, qhov siab tshaj ib hnub yog 150 mg,
KK 21-40 ml / min: qhov kev tso thawj thawj hnub yog 25 mg, qhov siab tshaj ib hnub yog 100 mg,
KK 10–20 ml / min: qhov kev tso thawj thawj hnub yog 12.5 mg, qhov siab tshaj plaws niaj hnub yog 75 mg,
QC tsawg dua 10 ml / min: qhov pib tshuaj thawj hnub yog 6.25 mg, qhov siab tshaj plaws ib hnub yog 37.5 mg.

Siv rau lub sijhawm qub

Ceev faj yuav tsum muab rau captopril-AKOS hauv cov neeg laus.

Thawj koob tshuaj rau cov neeg laus yog 6.25 mg 2 zaug ib hnub. Qhov kev noj tshuaj zoo no yuav tiv thaiv kom tsis txhob ua haujlwm lub raum, yog li nws tau pom tias zoo rau kev tswj xyuas qhov tsis haum. Nws raug nquahu kom kho qhov koob tshuaj Captopril-AKOS siv rau hauv tus neeg mob cov lus teb kho mob tsis tu ncua, tswj nws kom nyob rau hauv qis kawg nkaus.

Yeeb tshuaj sib cuam tshuam

angiotensin II receptor antagonists (ARA II), aliskiren thiab lwm yam tshuaj uas cuam tshuam rau RAAS: ua rau muaj kev pheej hmoo ntawm cov lus txo qis hauv cov ntshav siab, kev ua haujlwm tsis zoo rau lub raum (suav nrog mob raum tsis ua haujlwm), hyperkalemia. Hauv qhov no, yog tias tsim nyog, kev teem caij lwm yam tshuaj uas cuam tshuam rau RAAS yuav tsum ua tib zoo saib xyuas ntshav siab, ntsuas ntawm lub raum kev ua haujlwm, ntshav electrolytes. Nrog rau mob hnyav lub raum muaj nuj nqi thiab hom 2 mob ntshav qab zib mellitus, ua ke nrog aliskiren yuav tsum raug zam,
potassium-sparing diuretics (amiloride, triamteren, spironolactone, eplerenone), kev npaj poov tshuaj, cov tshuaj potassium, cov ntsev hloov: ntxiv rau kev pheej hmoo ntawm hyperkalemia, nws yog qhov tsim nyog los tswj lub plasma cov ntsiab lus,
diuretics (thiazide thiab "voj"): hauv cov koob tshuaj ntau ntxiv ua rau muaj kev cuam tshuam ntawm txoj kev mob ntshav liab,
diuretics, leeg ua kom lub zog, aldesleukin, alprostadil, cardiotonic, alpha₁-blockers, beta-blockers, central alpha₂-adrenomimetics, qeeb calcium calcium blockers, nitrates, minoxidil, vasodilators: hwj chim muaj txiaj ntsig hypotensive ntawm Captopril-AKOS,
Cov tshuaj tsaug zog, tshuaj tiv thaiv kev ntxhov siab, ntxhov siab, tshuaj tiv thaiv kev ntxhov siab: txhim kho cov nyhuv ntawm captopril,
non-steroidal anti-inflammatory tshuaj (NSAIDs), suav nrog indomethacin, xaiv cyclooxygenase-2 inhibitors, estrogens: nrog rau kev siv ntev, lawv txo cov txiaj ntsig ntawm captopril. Tsis tas li ntawd, kev sib xyaw ntawm NSAIDs thiab ACE inhibitors tuaj yeem muaj cov txiaj ntsig ntxiv rau kev ua kom muaj qhov nce ntxiv ntawm cov poov tshuaj poov tshuaj tiv thaiv cov keeb kwm yav dhau los ntawm kev txo qis hauv lub raum kev ua haujlwm (suav nrog mob raum tsis ua haujlwm), tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj keeb kwm tsis zoo los ua lub raum, cov neeg laus, lossis nrog txo qis cov ntshav ncig mus los. ,
ib qho tshuaj loog: ib qho los txo qis hauv cov ntshav thaum lub sijhawm ua haujlwm ntau yog ua tau, tshwj xeeb tshaj yog yog ib qho kev ua kom loog muaj cov nyhuv antihypertensive,
lithium npaj: cov roj ntsha lithium excretion qeeb thiab nws cov kev mob siab hauv cov ntshav nce siab,
allopurinol, procainamide: muaj kev pheej hmoo siab ntawm neutropenia thiab / lossis Stevens-Johnson syndrome,
glucocorticosteroids, epoetin, estrogens thiab sib xyaw ua ke ntawm qhov ncauj, naloxone, carbenoxolone: ua rau tsis muaj zog ntawm Captopril-AKOS,
kev npaj kub: iv kev tswj hwm ntawm sodium aurothiomalate tuaj yeem ua rau cov tsos mob hnyav hauv tus neeg mob, suav nrog kev txo cov ntshav, lub ntsej muag yaug, xeev siab, ntuav,
sympathomimetics: tuaj yeem txo cov kev kho mob hauv cov tshuaj captopril,
hypoglycemic cov neeg sawv cev rau kev tswj hwm ntawm qhov ncauj, insulin: nce qhov kev pheej hmoo ntawm hypoglycemia,
antacids: qeeb rau kev nqus ntawm captopril nyob rau hauv lub plab zom mov,
ethanol: txhim kho kev ua haujlwm hypotensive ntawm Captopril-AKOS,
probenecid: pab txo lub raum kev ua kom tiav ntawm captopril, uas ua rau muaj kev nce ntxiv hauv nws cov kev coj ua rau hauv ntshav dej,
azathioprine, cyclophosphamide: nce ntxiv ntawm kev txhim kho hematological cuam tshuam,
propranolol: nws cov bioavailability nce,
cimetidine: pab txhawm rau ua kom cov tshuaj lom ntau ntxiv hauv cov ntshav ntshav,
clonidine: txo qhov hnyav ntawm cov nyhuv antihypertensive.

Cov qauv ntawm Captopril-AKOS yog: Captopril, Captopril-Ferein, Captopril-FPO, Captopril-UBF, Captopril Velfarm, Kapoten, Katopil, Epsitron, Alkadil, Angiopril-25, Blockordil, Vero-Captopril, Captopril-Captopril-Captopril-Captril-Captopril-Captopril-Captopril-Captopril

Mechanism ntawm kev ua

Daim duab hauv qab no qhia txog cov nyhuv ntawm ACE inhibitor ntawm ob qhov kev hloov pauv tshuaj:

Kev cuam tshuam ntawm kev tsim ntawm angiotensin II, ib qho kev txo qis hauv nws cov concentration hauv cov ntshav.
Kev cuam tshuam ntawm kev rhuav tshem bradykinin rau cov nruab nrab nruab nrab, uas txhais tau hais tias pab txhawb nws cov tsub zuj zuj

Lub tswvyim ntawm cov nyhuv ntawm ACE inhibitor ntawm ob qhov kev hloov pauv tshuaj

Kev teb rau ib qho kev poob qis hauv cov ntshav lossis qhov xwm txheej ntxhov siab, tus renin peptide pib tso rau hauv lub raum. Nws ua rau cov protein angiotensinogen thiab hloov mus rau hauv angiotensin I. Ua rau nws hloov zuj zus, nws ua angiotensin II nrog kev pab ntawm angiotensin-hloov mus rau enzyme. Cov kab ke tag nrho hu ua renin-angiotensin-aldosterone (RAAS).

Angiotensin II muaj cov khoom hauv qab no:

txo cov leeg ntawm phab ntsa ntawm cov hlab ntsha, nqaim lumen. Qhov no ua rau muaj kev nce ntxiv hauv cov ntshav siab, nce cov load hauv lub plawv, ua rau cov ntshav xa mus rau cov kabmob hauv nruab nrog,
tsub kom lub siab ntawm aldosterone. Aldosterone, dhau los, ua rau kom cov kua dej ntau ntxiv hauv lub cev. Qhov no ua rau edema thiab ntxiv kev ntxhov siab ntawm cov hlab plawv cov ntshav. Rau qhov no, aldosterone nyob rau hauv lub raum raws absorbs sodium thiab tshem cov poov tshuaj,
txhawb nqa kev sib txuas ntawm ntau yam tshuaj tiv thaiv - cytokines. Lawv rhuav tshem thiab txhim kho sclerosis ntawm phab ntsa ntawm cov hlab ntsha, hlab plawv thiab lub raum.

Ntxiv rau RAAS, ACE inhibitors inhibit kinin-kallikrein system. Bradykinin muaj lub luag haujlwm rau ob txheej txheem:

kev so ntawm cov hlab ntsha, i.e. kev txo qis ntawm cov ntshav siab,
o thiab ua xua.

Tsuas tshuaj thiab tswj hwm

Captopril-AKOS yog noj ntawm ncauj li 1 teev ua ntej noj mov. Kev noj tshuaj yog muab teeb ib leeg zuj zus. Thaum ua tiav lub koob tshuaj ntawm captopril raws li cov cim qhia, nws yog ib qho tsim nyog siv cov tshuaj captopril hauv daim ntawv tshuaj: cov ntsiav tshuaj ntawm 12.5 mg.

Nrog rau kev mob ntshav siab, kho mob pib nrog kev siv tshuaj qis dua 12,5 mg 2 zaug hauv ib hnub (tsis tshua muaj 6.25 mg 2 zaug hauv ib hnub). Kev saib xyuas yuav tsum tau them rau qhov thev taus ntawm thawj koob thaum thawj teev. Yog tias txoj hlab ntshav hauv txoj kev mob ntshav nce los hauv qhov no, tus neeg mob yuav tsum tau tsiv mus rau qhov chaw tav toj (xws li qhov tshuaj tiv thaiv rau thawj koob yuav tsum tsis txhob muaj kev khuam siab rau kev kho ntxiv). Yog tias tsim nyog, qhov koob tshuaj yog maj mam (nrog ntu nruab nrab ntawm 2-4 lub lis piam) nce ntxiv kom txog thaum pom cov txiaj ntsig zoo tshaj. Nrog rau qhov mob sib khuav ntawm cov ntshav me lossis nruab nrab, cov txij nkawm ib txwm muaj li 25 mg 2 zaug hauv ib hnub, qhov ntau kawg yog 50 mg 2 zaug ib hnub. Hauv kev mob ntshav siab tshaj plaws, qhov ntau tshaj yog 50 mg 3 zaug ib hnub. Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 150 mg.

Hauv cov neeg laus cov neeg mob, thawj koob tshuaj yog 6.25 mg 2 zaug ib hnub.

Hauv kev mob plawv tsis ua haujlwm, nws tau sau ua ke nrog diuretics thiab / lossis kev sib xyaw nrog digitalis npaj (yuav kom tsis txhob muaj qhov pib ntshav siab ntau dhau, cov diuretic raug muab tso tseg lossis cov tshuaj raug txo ua ntej tswj hwm Captopril-AKOS). Thawj koob tshuaj yog 6.25 mg lossis 12.5 mg 3 zaug hauv ib hnub, yog tias tsim nyog, nce qhov koob tshuaj maj mam (ntawm ntu tsawg kawg 2 lub lis piam) txog 25 mg 2-3 zaug ib hnub. Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 150 mg.

Thaum muaj teeb meem ntawm sab laug ventricle tom qab kev txom nyem myocardial infarction hauv cov neeg mob hauv lub xeev qhov chaw ruaj khov, kev siv Captopril-AKOS tuaj yeem pib ntxov li 3 hnub tom qab myocardial infarction. Thawj koob tshuaj yog 6.25 mg / hnub, tom qab ntawd qhov kev noj tshuaj txhua hnub tuaj yeem nce ntxiv rau 37.5-75 mg nyob hauv 2-3 koob (nyob ntawm qhov yuav tsum tau tiv thaiv ntawm cov tshuaj). Yog tias tsim nyog, qhov koob tshuaj yog maj mam nce mus rau qhov siab tshaj plaws txhua hnub ntawm 150 mg / hnub. Nrog txoj kev loj hlob ntawm txoj hlab ntsha hypotension, koob tshuaj yuav tsum raug txo. Tom qab siv tshuaj kho qhov siab tshaj plaws txhua hnub ntawm 150 mg yuav tsum ua raws li kev tuaj yeem tiv thaiv los ntawm cov neeg mob ntawm Captopril-AKOS.

Nrog rau cov ntshav qab zib mob nephropathy, ib koob tshuaj txhua hnub ntawm 75-100 mg / hnub yog hais rau 2-3 koob tshuaj. Thaum muaj mob ntshav qab zib insulin-tiv thaiv cov ntshav qab zib nrog microalbuminuria (tso tawm albumin 30-300 mg rau ib hnub), qhov tshuaj yog 50 mg 2 zaug ib hnub. Nrog kev txiav tawm ntawm cov protein ntau ntawm ntau tshaj 500 mg rau ib hnub, cov tshuaj muaj txiaj ntsig ntawm koob tshuaj 25 mg 3 zaug ib hnub.

Nrog tus neeg kawm txog qib qis ntawm lub raum lub raum lub luag haujlwm (creatinine tshem tawm (CC) - tsawg kawg 30 ml / min / 1,73 m), Captopril-AKOS tuaj yeem tau txhaj tshuaj ntawm 75-100 mg / hnub. Nrog kev tshaj tawm txog qhov ua rau lub raum khiav tsis zoo (CC - tsawg dua 30 ml / min / 1.73 m), thawj koob yuav tsum tsis pub ntau tshaj 12,5 mg / hnub, tom qab ntawd, yog tias tsim nyog, koob tshuaj Captopril-AKOS tau maj mam nce ntawm qhov txaus sib nrug ntev lub sijhawm, tab sis siv tus me dua li ntawm kev kho mob ntawm txoj hlab ntshav siab, qhov tshuaj txhua hnub ntawm cov tshuaj. Yog tias tsim nyog, lub voj hluav taws xob tso tshuaj, thiab tsis siv tshuaj kho hyazide.

Sab sij huam

Nrog rau kev mob ntshav siab, kho mob pib nrog kev siv tshuaj qis dua 12,5 mg 2 zaug hauv ib hnub (tsis tshua muaj 6.25 mg 2 zaug hauv ib hnub). Kev saib xyuas yuav tsum tau them rau qhov thev taus ntawm thawj koob thaum thawj teev. Yog tias txoj hlab ntshav hauv txoj kev mob ntshav nce los hauv qhov no, tus neeg mob yuav tsum tsiv mus rau qhov chaw tav toj (xws li qhov tshuaj tiv thaiv rau thawj koob yuav tsum tsis muaj kev cuam tshuam rau kev kho ntxiv). Yog tias tsim nyog, qhov koob tshuaj yog maj mam (nrog ntu nruab nrab ntawm 2-4 lub lis piam) nce ntxiv kom txog thaum pom cov txiaj ntsig zoo tshaj. Nrog rau qhov mob sib khuav ntawm cov ntshav me lossis nruab nrab, cov txij nkawm ib txwm muaj li 25 mg 2 zaug hauv ib hnub, qhov ntau kawg yog 50 mg 2 zaug ib hnub. Hauv kev mob ntshav siab tshaj plaws, qhov ntau tshaj yog 50 mg 3 zaug ib hnub. Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 150 mg.

Hauv cov neeg laus cov neeg mob, thawj koob tshuaj yog 6.25 mg 2 zaug ib hnub.

Noj ntau dhau

Cov tsos mob: tus tshaj tawm txo nyob rau hauv cov ntshav siab, mus txog

cev qhuav dej, myocardial infarction, mob cerebrovascular mob hnyav, muaj teeb meem thromboembolic.

Kev Kho Mob: muab tus neeg mob nrog ceg qis qis dua, ntsuas ntsuas los kho kom ntshav siab (nce hauv cov ntshav cov ntshav ntau ntxiv, suav nrog iv infusion ntawm 0.9% sodium chloride tov), kho cov tsos mob. Tej zaum yuav siv cov tshuaj hemodialysis, tshuaj tiv thaiv peritoneal lim ntshav tsis zoo.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj uas txo cov kev ua haujlwm muaj lub siab xav tau yog coj los rau cov neeg mob noj captopril nrog ceev faj. Beta-blockers muab cov nyhuv me ntsis los tiv thaiv kev mob thaum ntxiv rau capropril, tab sis cov txiaj ntsig tag nrho yog tsawg dua li qhov xav.

Cov nyhuv tshuaj tiv thaiv kab mob yog tsis muaj zog los ntawm cov tshuaj tsis-steroidal los tiv thaiv cov tshuaj tiv thaiv (NSAIDs) (ncua Na + thiab txo prostaglandin synthesis), tshwj xeeb tshaj yog tiv thaiv keeb kwm ntawm qhov tsis tshua muaj siab ntawm renin, thiab estrogen (ncua Na +). Kev sib xyaw nrog thiazide diuretics, vasodilators (minoxidil), verapamil, beta-blockers, tricyclic antidepressants, ethanol txhim kho cov nyhuv hypotensive.

Kev siv sib xyaw nrog cov tshuaj potassium-sparing diuretics (piv txwv li triamteren, spironolactone, amiloride), cov tshuaj potassium, cyclosporine, mis ntsev tsawg (tej zaum yuav muaj K + txog 60 mmol / l), cov tshuaj ntxiv potassium, ntsev hloov pauv (muaj ntau ntawm K +) ntau ntxiv kev pheej hmoo ntawm kev tsim hyperkalemia.

Ua kom qis qis qis tshaj qhov tsis pom ntawm lithium kev npaj.

Nrog rau kev teem caij ntawm captopril thaum noj allopurinol lossis procainamide, qhov kev pheej hmoo ntawm kev tsim Stevens-Johnson syndrome thiab cov tshuaj tiv thaiv kab mob nce ntxiv. Kev siv cov tshuaj captopril hauv cov neeg mob noj tshuaj tiv thaiv kab mob (piv txwv li, azathioprine lossis cyclophosphamide) nce qhov kev pheej hmoo ntawm kev tsim hematological tsis zoo. Kev siv tshuaj ACE inhibitors thiab tshuaj insulin ib txhij, nrog rau cov tshuaj tiv thaiv ntshav qab zib hauv qhov ncauj tuaj yeem ua rau muaj kev txhim kho hypoglycemia. Qhov teeb meem loj tshaj plaws ntawm kev txhim kho hypoglycemia yog pom nyob rau thawj lub lim tiam ntawm kev sib txuam, nrog rau cov neeg mob uas lub raum tsis ua haujlwm. Cov neeg mob ntshav qab zib yuav tsum tau saib xyuas glycemia, tshwj xeeb tshaj yog thaum thawj lub hlis ntawm kev kho mob nrog ACE inhibitor.

Daim ntawv thov nta

Ua ntej pib, thiab tseem tsis tu ncua thaum kho nrog Captopril-AKOS, lub raum yuav tsum raug saib xyuas. Hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev, lawv tau raug siv los ntawm kev saib xyuas mob nkeeg zoo. Tawm tsam keeb kwm yav dhau los ntawm kev siv lub sijhawm ntev ntev ntawm Captopril-AKOS, kwv yees li 20% ntawm cov neeg mob tau nce siab ntawm urea thiab cov ntshav creatinine los ntawm ntau dua 20%, piv nrog kev suav lossis tus nqi pib. Tsawg dua li 5% ntawm cov neeg mob, tshwj xeeb tshaj yog cov neeg muaj kev puas hlwb loj, yuav tsum tau txais kev kho vim tias muaj kev cuam tshuam hauv creatinine ntau dua. Hauv cov neeg mob uas mob ntshav tawm tsam nrog Captopril-AKOS, kev mob ntshav siab ntau ntawm cov leeg ntshav yog pom tsuas yog qee qhov mob, qhov ntxim nyiam ntawm kev txhim kho tus mob no nce nrog qhov tsis muaj kua thiab cov ntsev tsis tau (piv txwv li, tom qab kho mob nrog diuretics), hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev los yog mob ntshav qis. Cov. Tseem ua tau kom ntshav siab me dua tuaj yeem txo qis nrog kev tshem tawm ua ntej (4-7 hnub) ntawm ib qho tshuaj diuretic lossis nce ntxiv ntawm sodium chloride kom tsawg (thaj tsam li ib lis piam ua ntej pib tswj), lossis los ntawm kev tswj hwm ntawm captopril thaum pib kho me me (6.25- 12,5 mg / hnub). Thaum kho los ntawm kev kho mob sab nraud, ceeb toom rau tus neeg mob txog qhov tshwm sim uas muaj tsos mob ntawm kev kis tus kab mob, yuav tsum tau kuaj mob ntxiv, soj ntsuam mob thiab kuaj ntshav. Hauv thawj 3 lub hlis. txoj kev kho txhua hli saib xyuas cov qe ntshav dawb, tom qab ntawd - 1 zaug hauv 3 hlis: hauv cov neeg mob autoimmune hauv thawj 3 lub hlis. - txhua 2 lub lis piam., tom qab ntawd - txhua 2 hlis ib zaug. Yog tias cov lej ntawm leukocytes qis dua 4000 / μl, ib qho kev kuaj ntshav dav dav yog qhov qis dua, qis dua 1000 / μl, cov tshuaj txiav tawm. Yog tias thawj cov tsos mob ntawm tus kab mob theem nrab tshwm sim tawm tsam keeb kwm ntawm myeloid hypoplasia, kev kuaj ntshav ntxaws ntxaws yuav tsum tau ua tam sim ntawd. Nws yog ib qho tsim nyog kom tshem tawm qhov tsis ua qhov kev ywj pheej ntawm cov tshuaj thiab ib qho kev ywj pheej ntxiv rau qhov kev siv dag zog ntawm kev siv dag zog. Qee qhov xwm txheej, tawm tsam keeb kwm ntawm kev siv ACE inhibitors, suav nrog captopril, muaj kev nce ntxiv hauv cov concentration ntawm cov poov tshuaj hauv cov ntshav ntshav. Txoj kev pheej hmoo ntawm kev tsim hyperkalemia nrog kev siv ACE inhibitors tau nce hauv cov neeg mob raum tsis ua haujlwm thiab mob ntshav qab zib mellitus, nrog rau kev noj cov tshuaj potassium-sparing diuretics, tshuaj potassium los yog lwm yam tshuaj uas ua rau muaj kev nce hauv ntau ntawm cov poov tshuaj hauv ntshav (piv txwv li, heparin). Kev siv tib txhij ntawm cov tshuaj potassium-sparing diuretics thiab potassium npaj yuav tsum zam. Thaum coj tus kab mob hemodialysis hauv cov neeg mob uas tau txais Captopril-AKOS, kev siv cov qib siab permeability dialysis raws li (piv txwv li AN69) yuav tsum zam, vim tias qee qhov kev pheej hmoo ntawm kev tsim cov tshuaj tiv thaiv anaphylactoid ntau zog. Nyob rau hauv txoj kev loj hlob ntawm angioedema, cov tshuaj raug muab tso tseg thiab meej kev saib xyuas kev kho mob thiab cov tsos mob kho yog nqa tawm. Thaum noj Captopril-AKOS, muaj qhov tsis zoo tshwm sim thaum soj ntsuam cov zis rau acetone. Lub peev xwm ntawm yeeb tshuaj los cuam tshuam rau kev coj tus cwj pwm lossis kev ua haujlwm ntawm lub cev, sib cuam tshuam nrog kev haus luam yeeb, haus dej cawv, zaub mov: thaum lub sijhawm kho mob, nws yog ib qho tsim nyog yuav tsum tsis kam tsav tsheb thiab ua rau muaj kev phom sij uas yuav tsum muaj kev nce siab ntawm kev saib xyuas thiab ceev ntawm psychomotor cov tshuaj tiv thaiv, vim tias kiv taub hau yog ua tau, tshwj xeeb tshaj yog tom qab noj thawj koob.

Kev tiv thaiv kev nyab xeeb

Cov kev ceev faj: siv rau cov kab mob autoimmune loj heev (tshwj xeeb tshaj yog cov kab mob lupus erythematosus lossis scleroderma), kev txwv tsis pub cov leeg pob txha hematopoiesis (kev pheej hmoo ntawm neutropenia thiab agranulocytosis), cerebral ischemia, ntshav qab zib mellitus (muaj kev pheej hmoo ntawm hyperkalemia), hauv cov neeg mob ua rau mob hemodialysis. Txwv tsis pub sodium, thawj hyperaldosteronism, mob plawv, mob ntshav nrog, nrog rau qhov txo qis hauv cov ntshav ncig (nrog rau mob raws plab, ntuav), thaum laus.

Nrog kev ceev faj, cov neeg mob uas noj zaub mov tsis muaj ntsev los yog ntsev tsawg (muaj kev pheej hmoo ntawm kev mob ntshav liab) thiab hyperkalemia tau sau tseg.

Dab tsi lub siab kuv yuav tsum coj?

Tshaj siab xav txog cov lej ntawm cov ntshav siab ntau dua 140/90 hli RT. Kos duab. Captopril AKOS yog yeeb tshuaj luv-luv. Nws cov nyhuv kav ntev txog 6 teev. Yog li, feem ntau, cov kws kho mob tau tshaj tawm txog kev kub ntxhov, rau kev siv tas li hauv kev kub siab tau sau tseg siv tshuaj yeeb ntev.

Koj tuaj yeem noj cov tshuaj nyob rau hauv thawj zaug ntawm kev mob ntshav siab, thaum qhov nce ntawm cov ntshav siab yog qhov tsis txaus ntseeg thiab tsis tshua muaj, thiab tom qab ntawd sab laj nrog koj tus kws kho mob. Tab sis nws tsis qhia nyob rau hauv cov lus qhia rau kev siv Captopril AKOS ntawm kev dab tsi yuav tsum coj. Yog li, yog tias qhov tshwm sim ntawm kev ua ntawm cov tshuaj haum rau tus neeg mob thiab tus kws kho mob koom nrog, ces koj tuaj yeem tawm ntawm txoj kev kho no raws li kev siv txuas ntxiv.

Cov lus qhia rau kev siv

Txhawm rau kom tsis txhob muaj kev phiv, lawv pib noj cov tshuaj nrog rau kev noj me me. Feem ntau muab tshuaj 6 rau 12 mg 3 zaug ib hnub.
Qhov txiaj ntsig yog ntsuas tom qab ob peb hnub, cov tshuaj yeeb tshuaj yuav tsum khaws cia hauv lub cev.
Yog tias cov koob tshuaj thaum pib tsis txaus kom tau txais cov nyhuv, ces qhov tshuaj tsuas yog maj mam nce mus rau 25-50 mg 2 zaug hauv ib hnub.
Ua kom ntau npaum li yuav tsum tau nruab hnub, koj tuaj yeem noj txog li 150 mg ntawm cov tshuaj.
Nrog kev kub siab tawg, qhov ntawd yog, thaum ntshav siab nce mus txog tus lej saum 180/110 mm RT.Txuj ci., Noj 25 mg ntawm Captopril thiab tos rau qhov txo qis hauv siab rau ib nrab ib teev.
Yog tias cov nyhuv tsis tshwm sim, ces koj tuaj yeem rov qab noj tshuaj ntxiv.

Lub Captopril AKOS yuav daws tau qhov siab ntev npaum li cas?

Cov tshuaj no tau pom hauv cov ntshav tom qab 15 feeb, qhov siab tshaj plaws ntawm cov tshuaj tshwm sim nyob rau hauv 60-90 feeb, tom qab ntawd txo qis.

Captopril ua rau 6 teev, yog li qhov ntau zaus ntawm kev tswj hwm yog 3 zaug.

Tus neeg mob tshuaj xyuas ntawm daim ntawv thov

Kev txheeb xyuas txog Katopril AKOS feem ntau zoo.

Qhov zoo ntawm cov tshuaj muaj xws li:

ceev pib ntawm cov nyhuv
tus nqi tsawg
yooj yim me me ntsiav tshuaj loj, yooj yim kom nqos,
tshem tawm ntawm xeev siab, mob taub hau,
tuaj yeem siv hauv tsev ua qhov kev pab ua ntej,
tuaj yeem siv rau qhov tsis tshua muaj siab nce nqi situationally.

Cov hauv qab no yog qhov tsis zoo ntawm cov tshuaj:

tsis kaj siab qaub saj
luv-sij hawm cuam tshuam
tsis haum rau kev siv txhua hnub, tas mus li,
Muaj ntau hom tshuaj kho tau zoo dua.

Dab tsi yog qhov txawv ntawm Captopril thiab Captopril AKOS?

Kev qhia ntawm Captopril AKOS tsis txawv ntawm kev qhia ntawm Captopril. Yog li dab tsi yog qhov sib txawv ntawm Captopril thiab Captopril AKOS? Lub prefix AKOS txhais tau hais tias qhov tshuaj yaj yeeb yog tsim los ntawm kev sib koom ua ke Kurgan zej zog ntawm kev npaj kho mob thiab cov khoom lag luam "Synthesis". Cov tuam txhab no tau ua haujlwm txij li xyoo 1958. Cov nroj tsuag tsim tawm ntau dua 3% ntawm cov khoom lag luam tshuaj los ntawm kev lag luam tshuaj Lavxias. Txhua yam khoom dhau los ua tau zoo tswj txhua qib ntawm kev tsim khoom.

Kev cuam tshuam nrog lwm yam tshuaj

Diuretic pawg tshuaj pab txhim kho kev ua haujlwm ntawm captopril, nce nws cov ntsiab lus hauv cov ntshav ntau zaus. Tsis muaj hypotensive teebmeem yog pom thaum noj nrog ib qho NSAIDs, tshwj xeeb yog indomethacin.

Tsis tas li ntawd, cov hauj lwm zoo ntawm kev siv tshuaj txo qis yog tias ua ke nrog cov tshuaj estrogens artificially thiab tib lub sijhawm, clonidine siv.

Tsis zoo ua ke nrog poov tshuaj thiab sodium ntsev ua rau ncua sij hawm tom kawg hauv lub cev, thiab ua rau qaug cawv.

Kev txhim kho ntawm xeev siab, ntuav thiab tsis nco qab yog cim nrog kev siv captopril tib lub sijhawm nrog kev npaj muaj kub.

Nws yog nruj me ntsis txwv tsis pub coj los ua ke nrog cov tshuaj xws li:

Allopurinol thiab procainamide - ua rau kev loj hlob ntawm Stevens-Jones syndrome, thiab tseem muaj kev pheej hmoo ntawm kev tsim thiab nce ntawm neutropenia.
Insulin - Muab txoj hauv kev txhim kho cov ntshav qog ntshav qab zib (nce ntshav qab zib kom ntau).
Cyclosporins - oliguria kev loj hlob, tawm tsam uas tsis ua hauj lwm lub raum hloov zuj zus.
Azathioprine-based immunosuppressants - ua rau cov tsim ntawm hematological pathologies (ntshav txhaws tsis txaus, tsis txaus ntseeg ntawm cov qe ntshav).

Yog tias koj yuav tsum siv Captopril thiab lwm yam tshuaj tib lub sijhawm, koj yuav tsum tau sab laj nrog koj tus kws kho mob txog kev muaj qhov tsis zoo tshwm sim.

Daim video: Cov Tsis Muaj Peev Xwm Ceev

Thaum cev xeeb tub

Captopril tsis yog siv rau hauv kev kho mob hauv cov poj niam cev xeeb tub, vim tias qhov no tuaj yeem cuam tshuam loj rau cov xwm txheej ntawm tus menyuam hauv plab, ua rau muaj teeb meem mob raum. Koj yuav tsum tsis kam noj tshuaj rau lub sijhawm pub niam mis, vim tias cov tshuaj txuam nrog mis zoo thiab tuaj yeem ua rau tus menyuam tsis mob siab dua.

Cov lus thiab cov xwm txheej ntawm kev cia

Lub txee lub neej ntawm Captoril Akos yog 24 lub hlis txij li hnub ua khoom siv, uas tau qhia ntawm pob. Khaws rau hauv qhov chaw qhuav, tsaus, ntawm qhov kub tsis tshaj 25 ° C.

Tus nqi nruab nrab hauv cov khw muag tshuaj Lavxias rau Captopril Akos tsis pub tshaj 25 rub rau lub hlwv ntawm 10 ntsiav tshuaj. Hauv Ukraine, cov tshuaj tuaj yeem tuaj yeem yuav ntawm tus nqi pheej yig - 25 hryvnia.

Ntawm cov tshuaj uas muaj cov nyhuv zoo li antihypertensive, peb tuaj yeem paub qhov txawv:

Feem ntau cov kev tshuaj xyuas ntawm cov neeg mob siv Captopril Akos los ua cov tshuaj qhia tau tias nws muaj txiaj ntsig zoo. Cov neeg mob nco tsis tsuas yog ua hauj lwm siab, tab sis kuj tseem muaj lwm qhov zoo:

tus nqi tsim nyog
zoo zam los ntawm lub cev,
tsis muaj teeb meem
cov hauj lwm zoo tau sau tseg tom qab txhaj thawj koob,
tuaj yeem raug siv ua ib feem ntawm txoj kev kho mob nyuaj.

Tsuas yog nyob rau kis raug rho tawm yog ib tus neeg tsis kam txais mus rau captopril qhia ua ib qho kev tsis haum tshuaj me (urticaria).

Xaus

Ua li no Captopril Akos muab kev ua haujlwm siab thiab tus nqi pheej yig, pub koj mus yuav cov tshuaj hauv lub tsev muag tshuaj yam ywj pheej. Kev txiav txim siab ntawm txhua tus kws kho mob cov lus pom zoo thiab cov lus qhia, cov tshuaj tsis muaj kev tiv thaiv tsis zoo. Nyob rau ntawm qhov muaj qhov tsis haum, ua ntej pib ntawm txoj kev kho, kev kuaj sim rau qhov tshwm sim ntawm kev phiv tshuaj yog qhov yuav tsum tau ua.

Hom, npe, muaj pes tsawg leeg thiab daim ntawv tso tawm

Captopril tam sim no muaj nyob rau ntau yam hauv qab no:

Captopril
Captopril Vero,
Captopril Hexal,
Captopril Sandoz,
Captopril-AKOS,
Captopril Acre
Captopril-Ros,
Captopril Sar,
Captopril-STI,
Captopril-UBF,
Captopril-Ferein,
Captopril-FPO,
Captopril Stada,
Captopril Egis.

Cov hom tshuaj no sib txawv ntawm ib leeg tsuas yog los ntawm muaj cov lus ntxiv hauv lub npe, uas qhia txog cov ntawv luv lossis npe zoo ntawm cov chaw tsim tshuaj ntawm hom tshuaj tshwj xeeb. Txwv tsis pub, Captopril ntau yam tsis muaj qhov sib txawv ntawm lwm tus, vim tias lawv tau tsim nyob rau hauv tib daim ntawv, muaj cov tshuaj nquag, thiab lwm yam Ntxiv mus, feem ntau cov tshuaj nquag siv hauv Captopril ntau yam zoo ib yam, vim nws tau yuav los ntawm cov tuam txhab loj Suav teb lossis Is Nrias teb.

Qhov sib txawv ntawm cov npe ntawm Captopril ntau yam yog vim qhov xav tau rau txhua lub tuam txhab kws kho mob kom sau npe cov tshuaj uas lawv tsim nyob hauv cov npe qub, uas txawv ntawm lwm tus. Thiab txij li yav dhau los, nyob rau lub sijhawm Soviet, cov chaw muag tshuaj no tau tsim tib lub Captopril siv tib lub thev naus laus zis, lawv tsuas sau ib lo lus ntxiv rau lub npe paub zoo, uas yog cov npe luv ntawm lub npe ntawm kev lag luam thiab, yog li, lub npe tshwj xeeb tau txais los ntawm txoj cai pom. txawv los ntawm lwm tus.

Yog li, tsis muaj qhov sib txawv ntawm qhov sib txawv ntawm cov tshuaj, thiab yog li ntawd, raws li txoj cai, lawv tau sib koom ua ke nyob rau hauv ib qho npe Captopril. Ntxiv mus rau hauv cov ntawv ntawm cov ntawv sau peb tseem yuav siv ib lub npe - Captopril - los txhais txhua yam ntawm nws yam.

Txhua hom ntawm Captopril muaj nyob rau hauv ib daim ntawv tsuas tshuaj - qhov no qhov ncauj ntsiav tshuaj. Raws li ib qho tshuaj muaj zog ntsiav tshuaj muaj tshuaj yeeb dej caw captopril, lub npe ntawm uas, qhov tseeb, tau muab lub npe tshuaj.

Captopril ntau yam muaj nyob hauv ntau qhov tshuaj, xws li 6.25 mg, 12.5 mg, 25 mg, 50 mg thiab 100 mg rau ib ntsiav tshuaj. Xws li ntau qhov ntau ntawm cov tshuaj tso cai rau koj xaiv qhov kev xaiv zoo tshaj plaws rau kev siv.

Raws li ntu ntu Captopril ntau yam tuaj yeem muaj ntau yam tshuaj yeeb yaj kiab, vim tias txhua lub lag luam tuaj yeem hloov kho lawv qhov muaj pes tsawg leeg, sim ua tiav qhov ntsuas pom ntawm kev ua tau zoo. Yog li, txhawm rau kom meej qhov muaj pes tsawg leeg ntawm cov koom haum pabcuam ntawm txhua qhov tshwj xeeb ntawm cov tshuaj, nws yog qhov yuav tsum tau ua tib zoo kawm daim ntawv foos txuas nrog cov lus qhia.

Daim ntawv qhia rau Captopril hauv Latin yog sau raws li hauv qab no:
Rp: Tab. Captoprili 25 mg No. 50
D.S. Siv 1/2 - 2 ntsiav tshuaj 3 zaug ib hnub.

Thawj kab ntawm cov tshuaj tom qab cov lus luv luv "Rp" qhia tias daim ntawv ntau npaum li cas (hauv qhov no Tab. - ntsiav tshuaj), lub npe tshuaj (qhov no, Captoprili) thiab nws cov tshuaj (25 mg). Tom qab lub cim "Tsis Muaj.", Cov naj npawb ntawm cov ntsiav tshuaj uas tus kws muag tshuaj yuav tsum tso tawm rau cov neeg nqa tshuaj yuav tsum tau qhia. Hauv kab thib ob ntawm daim ntawv qhia tom qab cov ntawv luv "D.S." cov ntaub ntawv raug qhia rau tus neeg mob muaj cov lus qhia tias yuav siv cov tshuaj li cas.

Dab tsi pab captopril (kho cov nyhuv)

Captopril lowers ntshav siab thiab txo qhov thauj ntawm lub siab. Raws li, cov tshuaj siv rau hauv kev kho mob ntawm txoj kev mob ntshav siab, mob plawv (mob plawv tsis ua haujlwm, ntshav hlab plawv, ntshav hlab plawv), zoo li mob ntshav qab zib mob nephropathy.

Qhov tshwm sim ntawm Captopril yog txhawm rau txhawm rau ua tiav ntawm cov enzyme, uas ua kom ntseeg tau cov hloov pauv ntawm angiotensin I mus rau angiotensin II, yog li ntawd, cov tshuaj yog rau pawg ntawm ACE inhibitors (angiotensin-hloov enzyme). Vim tias qhov kev txiav txim ntawm cov tshuaj, angiotensin II tsis tsim nyob rau hauv lub cev - cov khoom uas muaj cov nyhuv vasoconstrictor muaj zog thiab, raws li, nce ntshav siab. Thaum angiotensin II tsis ua, cov roj ntsha nyob twj ywm thiab, raws li, cov ntshav siab yog qhov qub thiab tsis nce ntxiv. Ua tsaug rau Captopril cov nyhuv, thaum noj tsis tu ncua, ntshav siab poob qis thiab ua raws li qhov tsim nyog thiab txais tau. Qhov siab tshaj plaws nyob rau hauv siab tshwm sim 1 - 1.5 teev tom qab noj Captopril. Tab sis yuav kom ua tiav qhov txo qis hauv cov siab, cov yeeb tshuaj yuav tsum tau noj tsawg kawg ob peb lub lis piam (4-6).

Kuj yog ib qho yeeb tshuaj txo cov kev ntxhov siab ntawm lub siab, nthuav dav cov lumen ntawm cov hlab ntsha, vim tias cov leeg plawv yuav tsum tau siv zog tsawg dua los thawb cov ntshav mus rau qhov aorta thiab pulmonary leeg. Yog li, captopril ntau ntxiv ntawm kev kam rau ntawm lub cev thiab lub siab kev ntxhov siab hauv cov neeg muaj kev puas tsuaj los ntawm lub siab lossis tus neeg uas tau raug mob myocardial infarction. Cov cuab yeej tseem ceeb ntawm Captopril yog qhov tsis muaj qhov cuam tshuam ntawm tus nqi ntawm cov ntshav siab thaum siv los kho mob plawv.

Tseem captopril txhim kho lub raum ntshav khiav thiab ntshav cov ntshav mus rau lub plawvraws li ib qho tshwm sim ntawm cov tshuaj uas siv nyob rau hauv txoj kev kho mob ntawm kev mob plawv mob ntshav qab zib thiab ntshav qab zib nephropathy.

Captopril yog qhov zoo tsim nyog rau kev koom ua ke nrog ntau yam kev sib txuas nrog lwm tus antihypertensive tshuajCov. Tsis tas li ntawd, Captopril tsis suav cov kua dej hauv lub cev, uas qhov txawv ntawm nws los ntawm lwm cov tshuaj tiv thaiv kabmob uas muaj cov khoom zoo sib xws. Yog vim li cas, thaum noj Captopril, koj tsis tas yuav siv tshuaj ntxiv rau kev tshem tawm edema tshwm sim los ntawm cov tshuaj antihypertensive.

General kev cai thiab tsuas noj tshuaj

Captopril yuav tsum noj ib teev ua ntej noj mov, nqos cov ntsiav tshuaj tag nrho, tsis muaj yoov, zom lossis tsoo nws hauv lwm txoj kev, tab sis nrog dej kom ntau (yam tsawg ib nrab khob).

Cov tshuaj ntawm captopril yog xaiv tau ib tus zuj zus, pib nrog qhov tsawg kawg nkaus, thiab maj mam nqa nws kom zoo. Tom qab noj thawj koob tshuaj 6.25 mg lossis 12.5 mg, ntshav siab yuav tsum ntsuas txhua ib nrab teev rau peb teev kom thiaj txiav txim tau cov tshuaj tiv thaiv thiab mob hnyav ntawm cov tshuaj tshwj xeeb rau ib tus neeg. Yav tom ntej, nrog kev nce ntxiv, qhov siab yuav tsum tau ntsuas qhov tsis tu ncua ib teev tom qab noj tshuaj.

Nws yuav tsum nco ntsoov tias qhov siab tshaj plaws tau tso cai niaj hnub noj ntawm captopril yog 300 mg. Noj cov tshuaj hauv qhov ntau tshaj 300 mg rau ib hnub tsis ua rau muaj zog txo cov ntshav siab ntau dua, tab sis provokes qhov nce ntxiv hauv qhov hnyav ntawm cov kev mob tshwm sim. Yog li, kev noj tshuaj Captopril ntau tshaj 300 mg ntawm ib hnub yog qhov ua rau neeg nyob tsis taus thiab ua tsis tau dab tsi.

Captopril rau siab (nrog rau cov leeg ntshav) pib noj 25 mg ib zaug ib hnub lossis 12,5 mg 2 zaug ib hnub. Yog tias tom qab 2 lub lim piam cov ntshav siab tsis poob rau qhov tsim nyog tau txais, tom qab ntawd cov koob tshuaj tau nce thiab noj 25-50 mg 2 zaug ib hnub. Yog tias thaum noj Captopril hauv cov tshuaj no ntau dua, lub siab tsis txo rau qhov tsim nyog tau txais, tom qab ntawd koj yuav tsum ntxiv rau Hydrochlorothiazide 25 mg rau ib hnub lossis beta-blockers.

Nrog rau kev kub ceev lossis mob me me, ib qho tshuaj txaus ntawm captopril feem ntau yog 25 mg 2 zaug hauv ib hnub. Hauv cov ntshav siab heev, qhov ntau ntawm Captopril raug hloov kho rau 50-100 mg 2 zaug hauv ib hnub, muab nws ntau dua li ob lub lis piam. Ntawd yog, hauv thawj ob lub lis piam, ib tus neeg noj 12,5 mg 2 zaug hauv ib hnub, tom qab ntawd dhau ob lub lim tiam - 25 mg 2 zaug hauv ib hnub, thiab lwm yam.

Nrog rau kev mob ntshav siab vim yog mob raum, Captopril yuav tsum noj ntawm 6.25 - 12,5 mg 3 zaug ib hnub. Yog tias tom qab 1 - 2 lub lis piam qhov siab tsis txo rau qhov tsim nyog tau txais txiaj ntsig, tom qab ntawd cov tshuaj ntau dua thiab noj 25 mg 3-4 zaug hauv ib hnub.

Hauv lub plawv tsis ua haujlwm Captopril yuav tsum pib noj ntawm 6.25 - 12,5 mg 3 zaug ib hnub. Tom qab ob lub lis piam, qhov ntau npaum li cas yog ob npaug, nqa qhov siab tshaj plaws ntawm 25 mg 3 zaug hauv ib hnub, thiab cov tshuaj tau siv sijhawm ntev. Hauv plawv tsis ua haujlwm, Captopril yog siv nrog cov tshuaj diuretics lossis plauv plawv glycosides.
Ntau Txog Hais Txog Lub Plawv Tsis Txaus

Nrog myocardial infarction Captopril tuaj yeem noj nyob rau hnub peb tom qab lub sijhawm mob tag. Hauv thawj 3-4 hnub, nws yog ib qho tsim nyog yuav tau noj 6.25 mg 2 zaug hauv ib hnub, tom qab ntawd cov koob tshuaj tau nce rau 12,5 mg 2 zaug hauv ib hnub thiab qaug rau ib vas thiv. Tom qab qhov no, nrog kev tiv thaiv zoo ntawm cov tshuaj, nws raug nquahu kom hloov mus rau 12,5 mg peb zaug hauv ib hnub rau 2 txog 3 lub lis piam. Tom qab lub sijhawm no, nyob rau hauv cov xwm txheej ntawm kev tiv taus ib txwm ntawm cov tshuaj, lawv hloov mus rau 25 mg 3 zaug hauv ib hnub nrog kev tswj hwm tus mob. Ntawm cov tshuaj no, captopril noj tau ntev. Yog tias qhov tshuaj ntawm 25 mg 3 zaug hauv ib hnub yog qhov tsis txaus, tom qab ntawd nws raug tso cai kom ntau ntxiv - 50 mg 3 zaug ib hnub.
Ntau Txog Txog Myocardial Infarction

Nrog rau cov ntshav qab zib nephropathy Captopril pom zoo kom noj 25 mg 3 zaug hauv ib hnub lossis 50 mg 2 zaug ib hnub. Nrog microalbuminuria (albumin hauv cov zis) ntau dua 30 mg rau ib hnub, cov tshuaj yuav tsum noj 50 mg 2 zaug hauv ib hnub, thiab nrog proteinuria (protein hauv cov zis) ntau dua 500 mg rau ib hnub Captopril haus 25 mg 3 zaug hauv ib hnub. Cov koob tshuaj hais qhia tau nce zuj zus, pib nrog qhov tsawg kawg, thiab nce ntxiv ob zaug txhua ob lub lis piam. Qhov tsawg kawg nkaus ntawm cov tshuaj captopril rau cov mob nephropathy tuaj yeem sib txawv, vim nws tau txiav txim siab los ntawm cov neeg kawm ntawv lub siab. Kev siv tshuaj tsawg kawg nkaus uas yuav pib noj Captopril rau ntshav qab zib nephropathy, nyob ntawm seb lub raum ua haujlwm li cas tau qhia hauv lub rooj.

*Creatinine tshem tawm, ml / min (txiav txim siab los ntawm Reberg test)*	*Thawj koob tshuaj txhua hnub ntawm Captopril, mg*	*Qhov siab tshaj plaws niaj hnub noj cov tshuaj captopril, mg*
40 thiab saum toj no	25 - 50 mg	150 mg
21 – 40	25 mg	100 mg
10 – 20	12,5 mg	75 mg
Tsawg dua 10	6.25 mg	37,5 mg

Qhov qhia tshuaj txhua hnub yuav tsum tau faib ua 2 rau 3 koob tshuaj ib hnub. Cov neeg laus (tshaj 65), tsis hais txog lub raum kev ua haujlwm, yuav tsum pib noj cov tshuaj ntawm 6.25 mg 2 zaug hauv ib hnub, thiab tom qab ob lub lis piam, yog tias tsim nyog, nce qhov ntau dua 12,5 mg 2 txog 3 zaug hauv ib hnub.

Yog tias ib tug neeg mob mob raum (tsis mob ntshav qab zib nephropathy), ntau npaum li cas ntawm Captopril rau nws kuj tau txiav txim siab los ntawm creatinine tshem tawm thiab yog tib yam li muaj ntshav qab zib nephropathy.

Siv thaum cev xeeb tub thiab pub niam mis

Captopril yog contraindicated rau kev siv thoob plaws lub cev xeeb tub, txij li kev tshawb fawb txog tsiaj muaj pov thawj nws cov tshuaj lom rau ntawm tus menyuam hauv plab. Noj cov tshuaj los ntawm 13th mus rau 40 lub lis piam ntawm cev xeeb tub tuaj yeem ua rau me nyuam hauv plab tuag lossis ua tsis tiav.

Yog tias tus poj niam tab tom noj captopril, ces nws yuav tsum tau muab tshem tawm sai li sai tau, sai li sai tau paub txog kev pib ntawm kev xeeb tub.

Captopril nkag mus rau hauv cov mis, yog li tsim nyog, koj yuav tsum tsis kam pub mis rau menyuam thiab muab nws hloov mus rau hauv cov khoom siv sib tov.

Cov lus qhia tshwj xeeb

Rau cov menyuam yaus hnub nyoog qis dua 18 xyoo, Captopril tsuas yog siv thaum muaj xwm txheej ceev, suav cov tshuaj ntau npaum li cas raws li lub cev qhov hnyav, raws li qhov sib piv ntawm 1 - 2 mg rau 1 kg ntawm qhov hnyav ib hnub.

Yog tias koj plam cov ntsiav tshuaj tom ntej, tom qab ntawd lwm zaus koj yuav tsum noj cov tshuaj li ib txwm noj, tsis yog siv ob npaug.

Ua ntej pib captopril, nws yog qhov yuav tsum tau rov qab ua qhov ntim ntawm cov kua dej thiab cov tshuaj electrolytes hauv cov ntshav yog lawv pom tias muaj qhov txawv txav vim yog diuretics, mob plab zawv plab, ntuav, thiab lwm yam.

Lub sijhawm tag nrho ntawm kev siv Captopril, nws yog qhov tsim nyog los tswj kev ua haujlwm ntawm lub raum. Hauv 20% ntawm tib neeg, thaum noj cov tshuaj, proteinuria (protein nyob hauv cov zis) yuav tshwm sim, uas ntawm nws tus kheej hla li ntawm 4 txog 6 lub lim tiam yam tsis muaj kev kho mob. Txawm li cas los xij, yog tias qhov concentration ntawm cov protein nyob hauv cov zis yog siab dua 1000 mg ib hnub (1 g / hnub), tom qab ntawv cov tshuaj yuav tsum tsis ua ntxiv.

Captopril yuav tsum siv nrog ceev faj thiab nyob rau hauv kev saib xyuas kev noj qab haus huv yog tias ib tug neeg muaj cov xwm txheej lossis kab mob:

Mob leeg vasculitis,
Diffuse cov kab mob ntawm cov ntaub so ntswg sib txuas,
Ob leeg lub raum leeg mob leeg,
Txais tos ntawm immunosuppressants (Azathioprine, Cyclophosphamide, thiab lwm yam), Allopurinol, Procainamide,
Nqa tawm ntawm txoj kev kho txoj kev kho kom tsis tu ncua (piv txwv li muv venom, SIT, thiab lwm yam).

Ua ib qho kev ntsuas ntshav dav dav txhua ob lub lim tiam hauv thawj peb lub hlis ntawm kev kho. Tom qab, kuaj ntshav tau ua ntu zus, txog thaum kawg ntawm Captopril. Yog tias tag nrho cov lej ntawm leukocytes txo qis dua 1 G / l, tom qab ntawd cov tshuaj yuav tsum tau txiav tawm. Feem ntau, cov naj npawb ntawm cov qe ntshav dawb hauv cov ntshav tau rov qab los li 2 lub lis piam tom qab kev tsum tsis siv tshuaj. Ib qho ntxiv, nws yog qhov yuav tsum txiav txim siab qhov concentration ntawm cov protein nyob hauv cov zis, ntxiv rau creatinine, urea, tag nrho cov protein thiab poov tshuaj hauv cov ntshav thaum lub sijhawm tag nrho ntawm kev noj Captopril txhua lub hlis. Yog tias cov concentration ntawm cov protein hauv cov zis yog siab dua 1000 mg ib hnub (1 g / hnub), tom qab ntawd cov tshuaj yuav tsum tsis ua ntxiv. Yog hais tias kev mloog ntawm urea lossis creatinine hauv cov ntshav nce siab zuj zus, tom qab ntawd cov tshuaj ntawm cov tshuaj yuav tsum raug txo kom tsawg lossis nws yuav tsum tso tseg.

Txo txoj kev pheej hmoo ntawm qhov txo qis siab nyob rau hauv lub siab thaum pib ntawm captopril, nws yog ib qho tsim nyog yuav tsum tso tseg cov tshuaj diuretics los yog txo lawv cov tshuaj ntau npaum li 2 mus rau 3 zaug 4 rau 7 hnub ua ntej thawj cov ntsiav tshuaj Yog tias, tom qab noj Captopril, ntshav siab poob qis, qhov ntawd yog, hypotension pib, ces koj yuav tsum pw ntawm koj sab nraub qaum thiab tsa koj ob sab ceg kom lawv siab dua koj lub taub hau. Hauv txoj haujlwm no, nws yog ib qho tsim nyog kom pw rau 30-60 feeb. Yog tias hypotension yog qhov hnyav, tom qab ntawd kom tshem tawm nws sai, koj tuaj yeem nkag mus rau hauv ib txwm li cov tshuaj ntsev ua kom muaj kua tshuaj rau hauv lub cev.

Txij li thawj zaug tshuaj ntawm Captopril feem ntau ua rau hypotension, nws raug nquahu kom xaiv cov tshuaj ntau thiab pib siv rau hauv tsev kho mob nyob rau hauv kev saib xyuas tas li ntawm cov neeg kho mob.

Tawm tsam keeb kwm yav dhau los ntawm kev siv Captopril, txhua qhov kev phais mob, suav nrog kev kho hniav (piv txwv, kev rho tawm hniav), yuav tsum ua nrog ceev faj. Kev siv cov tshuaj loog thaum siv Captopril tuaj yeem ua rau lub zog poob qis, yog li tus neeg siv tshuaj loog yuav tsum ceeb toom tias ib tug neeg noj cov tshuaj no.

Nrog kev txhim kho jaundice, koj yuav tsum tam sim ntawd tsum tsis txhob noj Captopril.

Rau lub sijhawm tag nrho ntawm kev siv tshuaj, nws raug nquahu kom tso tseg txhua qhov kev haus dej cawv.

Ntawm lub keeb kwm yav dhau los ntawm kev noj cov tshuaj, qhov kev ntsuas tsis zoo rau cov tshuaj acetone hauv cov zis yuav raug sau tseg, uas yuav tsum tau yug hauv siab ob leeg los ntawm tus kws kho mob thiab tus neeg mob nws tus kheej.

Nws yuav tsum nco ntsoov tias yog tias cov cim hauv qab no tshwm sim ntawm keeb kwm ntawm Captopril, koj yuav tsum sab laj nrog kws kho mob:

Txhua yam kab mob kis, xam nrog rau khaub thuas, mob khaub thuas, thiab lwm yam.
Cov dej hauv lub cev ua kom ntau ntxiv (piv txwv li, nrog ntuav, raws plab, tawm hws ntau dhau, thiab lwm yam).

Kev siv cov tshuaj captopril qee zaum ua rau hyperkalemia (nce qib ntawm cov poov tshuaj hauv cov ntshav). Tshwj xeeb yog kev pheej hmoo siab ntawm hyperkalemia nyob rau hauv cov neeg kev txom nyem los ntawm mob raum tsis ua haujlwm lossis ntshav qab zib mellitus, nrog rau cov neeg tom qab noj ntsev tsis muaj zaub mov. Yog li, tawm tsam cov keeb kwm yav dhau los ntawm kev siv Captopril, nws yog qhov yuav tsum tsis kam noj cov tshuaj potassium-sparing diuretics (Veroshpiron, Spironolactone, thiab lwm yam), cov tshuaj potassium npaj (Asparkam, Panangin, thiab lwm yam) thiab heparin.

Tawm tsam keeb kwm yav dhau los ntawm kev siv Captopril, ib tus neeg yuav pib ua pob rau lub cev, feem ntau tshwm sim hauv thawj 4 lub lis piam ntawm kev kho mob thiab ploj nrog qhov txo qis hauv kev noj tshuaj lossis nrog kev tswj hwm ntxiv ntawm antihistamines (piv txwv li Parlazin, Suprastin, Fenistil, Claritin, Erius, Telfast, thiab lwm yam). Tsis tas li, thaum noj Captopril, kev hnoos tsis tu ncua (tsis muaj hnoos qeev), saj cov nyom thiab poob phaus yuav tshwm sim, txawm li cas los xij, tag nrho cov kev mob tshwm sim ploj li 2 rau 3 hlis tom qab cov tshuaj txiav tawm.

Kev cuam tshuam nrog lwm yam tshuaj

Captopril ua rau cov nyhuv ntawm cov tshuaj hypoglycemic (Metformin, Glibenclamide, Gliclazide, Miglitol, Sulfonylurea, thiab lwm yam), yog li ntawd, thaum muab tso ua ke, cov ntshav qabzib yuav tsum tau soj ntsuam tas li. Ntxiv rau, Captopril txhim kho cov txiaj ntsig ntawm cov tshuaj rau tshuaj loog, tshuaj pleev xim thiab dej cawv.

Diuretics thiab vasodilators, antidepressants, antipsychotics, Minoxidil thiab Baclofen nce cov nyhuv hypotensive ntawm Captopril, vim li ntawd, thaum siv ua ke, ntshav siab tuaj yeem txo qis. Beta-blockers, ganglion blockers, pergolide thiab interleukin-3 muaj txiaj ntsig txhim kho cov nyhuv hypotensive ntawm Captopril, tsis tas yuav ua rau lub zog txo qis.

Thaum siv captopril sib xyaw nrog nitrates (nitroglycerin, sodium nitroprusside, thiab lwm yam), nws yog qhov tsim nyog los txo cov tshuaj ntawm cov tom kawg.

NSAIDs (Indomethacin, Aspirin, Ibuprofen, Nimesulide, Nise, Movalis, Ketanov, thiab lwm yam), aluminium hydroxide, magnesium hydroxide, carbonate hydroxide, orlistat thiab clonidine txo qhov hnyav ntawm Captopril.

Captopril ua rau kom cov tshuaj lithium thiab digoxin ntau ntxiv hauv cov ntshav. Raws li, noj cov tshuaj lithium npaj nrog Captopril tuaj yeem ua rau kev loj hlob ntawm cov tsos mob ntawm lithium intoxication.

Kev siv captopril nrog cov tshuaj tiv thaiv kab mob ua ke (Azathioprine, Cyclophosphamide, thiab lwm yam), Allopurinol, lossis Procainamide ua rau muaj kev pheej hmoo ntawm neutropenia (txo cov qe ntshav dawb hauv qab ib txwm) thiab Stevens-Johnson syndrome.

Kev siv cov tshuaj captopril tiv thaiv keeb kwm ntawm kev kho mob kom tsis tu ncua, ntxiv rau kev sib xyaw nrog estramustine thiab gliptins (linagliptin, sitagliptin, thiab lwm yam) ntxiv qhov kev pheej hmoo ntawm kev tsis haum tshuaj anaphylactic.

Kev siv cov captopril nrog kub npaj (Aurothiomolate thiab lwm tus) ua rau daim tawv nqaij liab, xeev siab, ntuav thiab ua rau ntshav nce siab.

Sab Sij Huam ntawm Captopril

Cov ntsiav tshuaj Captopril tuaj yeem ua rau cov kev mob tshwm sim hauv qab no los ntawm ntau yam kabmob thiab cov tshuab:

1.Tej leeg hauv siab thiab cov plab hnyuv siab raum:

Qaug zog,
Kiv taub hau
Mob taub Hau
Kev tawm tsam ntawm lub hauv nruab nrab cov hlab hlwb,
Kev nkees nkees
Tsis meej pem,
Kev Nyuaj Siab
Ataxia (kev sib koom tes tsis zoo ntawm kev txav mus los),
Cramps
Paresthesia (kev hnov ntawm loog, tingling, "goosebumps" hauv nqua),
Tsis pom kev lossis hnov tsw,
Saj tsis cuam tshuam
Tsaus muag.

2.Kev mob plawv thiab ntshav:

Hypotension (ntshav siab)
Orthostatic hypotension (poob siab ntawm lub siab thaum tsiv los ntawm qhov chaw zaum lossis dag rau qhov chaw sawv)
Angina pectoris,
Myocardial infarction
Arrhythmia
Lub plawv dhia
Mob cerebrovascular mob,
Sab Nraud Nruab Nruab,
Lymphadenopathy
Mob Kev Plab
Kev mob hauv siab
Raynaud's Syndrome
Lub nthwv dej
Pallor ntawm daim tawv nqaij
Cardiogenic poob siab,
Ntshav nyob hauv thromboembolism,
Neutropenia (txo qis hauv neutrophils hauv cov ntshav),
Agranulocytosis (kev ploj tag ntawm basophils, eosinophils thiab neutrophils los ntawm cov ntshav),
Thrombocytopenia (txo cov roj ntshav hauv qab qis dua ib txwm),
Eosinophilia (nce ntxiv ntawm eosinophils saum toj ib txwm).

3.Kab mob ua pa:

Bronchospasm,
Txog siav
Kab mob ntsws los ntawm nruab nrab,
Mob ntsws ntsws
Rhinitis
Kev hnoos tsis zoo (tsis muaj hnoos qeev tawm).

4.Lub plab zom mov:

Kev Mob Nkeeg
Saj tsis cuam tshuam
Stomatitis
Qhov mob txhab rau ntawm lub plab ntawm lub qhov ncauj thiab lub plab,
Xerostomia (qhov ncauj qhuav vim yog tsis muaj salivation tsis txaus),
Glossitis (mob rau tus nplaig),
Gingival hyperplasia,
Nyuaj nqos nyuaj,
Xeev siab
Ntuav
Dyspepsia (pom zoo, tsam plab, mob plab, mloog qhov hnyav ntawm lub plab tom qab noj mov, thiab lwm yam),
Cem quav
Zawv plab
Kev mob caj dab
Cholestasis
Mob siab mob siab
Kab mob siab Hepatocellular.

5.Cov Kab Mob Hlob thiab Qog Loj:

Lub raum khiav tsis zoo, mus txog rau lub raum tsis ua haujlwm,
Polyuria (tso zis tawm ntau dua li ib txwm),
Oliguria (tso zis zis tsawg dua qub),
Proteinuria (protein hauv cov zis),
Ntxiv ntau zaus thiab tus lej muaj mob ceev
Cuam meem txom.

6.Cov tawv nqaij thiab cov nqaij mos:

Lub ntsej muag liab
Cov muaj pob nyob ntawm lub cev
Cov tawv nqaij khaus
Exfoliative dermatitis,
Tshuaj lom neeg mob ua paug,
Pemphigus
Erythroderma,
Tinea ntau yam xim
Alopecia (mas tsuas),
Photodermatitis.

7.Kev tsis haum tshuaj:

Stevens-Johnson Mob
Urticaria,
Quincke's edema,
Anaphylactic poob siab.

8.Lwm tus:

Ua npaws
Ua daus no
Sepsis (ntshav lom),
Arthralgia (mob pob qij txha)
Myalgia (mob leeg),
Hyperkalemia (nce poov tshuaj nyob rau hauv cov ntshav saum toj ib txwm),
Hyponatremia (txo qis hauv qib hauv sodium hauv cov ntshav qis dua ib txwm),
Kev mob ntshav qab zib (ntshav qabzib tsawg) hauv cov neeg tib lub sijhawm noj tshuaj insulin lossis lwm yam tshuaj ntshav qog ntshav siab,
Gynecomastia
Ntshav dej mob
Ntxiv kev ua haujlwm ntawm daim siab enzymes (AsAT, AlAT, phosphatase alkaline, thiab lwm yam),
Muaj kev nce siab ntawm urea, creatinine thiab bilirubin hauv cov ntshav, ntxiv rau ESR,
Txo hemoglobin thiab hematocrit
Acidosis
Kev ntsuas cuav tsis zoo rau kev kuaj pom ntawm lub nuclear antigen.

Captopril - Kev Ntxaib

Tam sim no, hauv kev lag luam tshuaj hauv tsev, Captopril muaj ob hom tshuaj analogues - cov no yog cov lus ua tau thiab, qhov tseeb, analogues. Cov Cov Lus Txhais suav nrog cov tshuaj uas muaj tib yam tshuaj zoo ib yam li Captopril. Cov tshuaj Analogues suav nrog cov tshuaj uas muaj cov tshuaj nquag sib txawv ntawm Captopril, tab sis zwm rau cov pab pawg ntawm ACE inhibitors thiab, raws li, muaj cov yeeb yam zoo sib xws ntawm kev kho mob.

Synonymous nrog Captopril Cov tshuaj hauv qab no yog:

Angiopril-25 ntsiav tshuaj,
Blockordil ntsiav tshuaj
Kapoten ntsiav tshuaj.

Captopril analogues los ntawm cov pab pawg ntawm ACE inhibitors yog cov tshuaj hauv qab no:

Acupro tshuaj ntsuab
Amprilan ntsiav tshuaj
Ntsiav tshuaj Arentopres,
Bagopril ntsiav tshuaj
Burlipril 5, Burlipril 10, Burlipril 20 ntsiav tshuaj,
Wazolong Capsules,
Ntsiav tshuaj hypernick,
Hopten tsiav tshuaj,
Dapril ntsiav tshuaj
Cov tshuaj ntsiav Dilaprel,
Diropress ntsiav tshuaj
Diroton ntsiav tshuaj
Zokardis 7.5 thiab Zokardis 30 ntsiav tshuaj,
Zonixem ntsiav tshuaj
Inhibeys ntsiav tshuaj,
Cov ntsiav tshuaj hem
Quadropril ntsiav tshuaj
Ntsiav tshuaj Quinafar,
Ntsiav tshuaj Coverex,
Corpril ntsiav tshuaj
Ntsiav tshuaj lysacard,
Lysigamma ntsiav tshuaj,
Lisinopril ntsiav tshuaj,
Lisinotone ntsiav tshuaj,
Lysiprex ntsiav tshuaj
Ntsiav tshuaj hauv pob qij txha,
Ntsiav tshuaj lysoril
Cov tshuaj ntsiav Listril
Liten ntsiav tshuaj
Methiapril ntsiav tshuaj,
Monopril ntsiav tshuaj
Moex 7.5 thiab Moex 15 ntsiav tshuaj,
Parnawel ntsiav tshuaj thiab tsiav tshuaj,
Ntsiav tshuaj perindopril
Perineva thiab Perineva Ku-tab ntsiav tshuaj,
Perinpress ntsiav tshuaj
Cov ntsiav tshuaj Pyramil
Ntsiav tshuaj pyristar,
Ntsiav tshuaj
Prestarium thiab Prestarium Ib ntsiav tshuaj,
Ramigamma ntsiav tshuaj,
Ramicardia tshuaj ntsuab,
Ramipril ntsiav tshuaj
Cov ntsiav tshuaj tuab,
Renipril ntsiav tshuaj
Renitec ntsiav tshuaj
Rileys-Sanovel ntsiav tshuaj,
Sinopril ntsiav tshuaj
Cov Tshuaj Nres Tsheb,
Tritace tshuaj,
Fosicard ntsiav tshuaj,
Fosinap ntsiav tshuaj,
Fosinopril ntsiav tshuaj,
Fosinotec cov ntsiav tshuaj
Hartil ntsiav tshuaj
Tshuaj ntsiav Hinapril,
Ednit ntsiav tshuaj
Ntsiav tshuaj Enalapril,
Enam ntsiav tshuaj
Enap thiab Enap P ntsiav tshuaj,
Cov ntsiav tshuaj tsis tshua muaj neeg
Enapharm ntsiav tshuaj,
Cov tshuaj kho kab mob muag.

Feem ntau kev tshuaj xyuas ntawm Captopril (tshaj 85%) yog qhov zoo, vim tias qhov muaj txiaj ntsig zoo ntawm cov tshuaj hauv kev txo cov ntshav siab. Cov kev txheeb xyuas pom tau tias cov tshuaj ua haujlwm sai thiab zoo txo qhov siab, yog li ua kom lub cev zoo. Qhov kev tshuaj xyuas tseem qhia tau tias Captopril yog ib qho tshuaj zoo tshaj plaws rau kev txo qis thaum muaj kev kub ntxhov siab. Txawm li cas los xij, rau kev siv mus sij hawm ntev hauv kev kub siab, Captopril tsis yog txoj hauv kev xaiv, vim nws muaj ntau cov kev mob tshwm sim uas tsis pom nyob hauv cov tshuaj muaj niaj hnub no.

Muaj ntau qhov tsis tshua muaj kev tshuaj xyuas txog Captopril thiab lawv feem ntau yog los ntawm kev txhim kho ntawm cov kev mob tshwm sim tsis zoo uas yuam kom tsis kam noj tshuaj.

Captopril lossis Enalapril?

Captopril thiab Enalapril yog cov tshuaj uas zoo ib yam, uas yog, lawv koom nrog tib pawg tshuaj thiab muaj cov yeeb yam zoo sib xws. Qhov no txhais tau hais tias ob qho tib si captopril thiab enalapril txo cov ntshav siab thiab txhim kho kev mob plawv hauv lub plawv tsis ua haujlwm ntev. Txawm li cas los xij, muaj qee qhov sib txawv ntawm cov tshuaj.

Ua ntej, nrog kev mob ntshav qis mus txog rau qib nrab, Enalapril yog txaus noj ib zaug ib hnub, thiab Captopril yuav tsum haus cawv 2 mus rau 3 zaug hauv ib hnub vim yog ncua sijhawm luv luv ntawm kev ua. Tsis tas li ntawd, enalapril zoo dua tswj lub siab ntawm theem ib txwm nrog kev siv ntev.

Yog li, peb tuaj yeem xaus lus tias enalapril yog qhov ntau dua li siv tshuaj rau lub caij nyoog siv kom tswj tau cov ntshav siab nyob hauv qhov tsim nyog. Thiab Captopril yog qhov tsim nyog dua rau ntu kev txo qis ntawm cov neeg nce siab.

Txawm li cas los xij, Captopril, piv nrog Enalapril, muaj cov txiaj ntsig zoo dua rau cov xwm txheej ntawm lub plawv hauv lub plawv tsis ua haujlwm ntev, txhim kho lub neej muaj txiaj ntsig zoo, nce kev zam ntawm lub cev thiab lwm yam kev ntxhov siab, thiab tseem tuaj yeem tiv thaiv kev tuag los ntawm kev mob plawv sai sai. Yog li no, yog tias mob ntev los ntawm lub plawv tsis ua haujlwm lossis lwm yam kab mob hauv lub plawv, captopril yuav yog cov tshuaj uas nyiam.
Ntxiv rau ntawm Enalapril