Cov lus qhia rau kev siv tshuaj Telsartan thiab tshuaj xyuas txog nws

Txhua Txog Ntshav Qab Zib »Yuav Siv Telsartan 40 li cas?

Tus naj npawb ntawm cov tshuaj uas ua rau txo cov ntshav siab thiab tswj nws hauv qib siab yog suav nrog Telsartan 40 mg. Cov txiaj ntsig zoo ntawm cov tshuaj: noj 1 ntsiav tshuaj ib hnub, lub sijhawm ntev ntawm cov txiaj ntsig antihypertensive, tsis muaj kev cuam tshuam lub siab. Qhov ntsuas qhia ntawm systolic thiab diastolic ntshav siab ntau li ntau tau txo qis tom qab tsuas yog ib hlis ib hlis siv cov tshuaj tsis tu ncua.

• 8,10 los ntawm daim siab thiab ua pa
• 8.11 Ua xua
• 8.12 Qhov cuam tshuam rau kev muaj peev xwm tswj hwm kev tshuab

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj yog cov ntsiav tshuaj dawb oval tsis muaj lub plhaub, convex ntawm ob sab. Nyob rau sab qaum kev ntawm lawv ib leeg muaj kev pheej hmoo rau qhov yooj yim ntawm kev tawg thiab cov tsiaj ntawv "T", "L", nyob rau hauv qis dua - tus lej "40". Sab hauv, koj tuaj yeem pom 2 txheej: ib qho yog pinkish hauv xim ntawm ntau yam sib zog, lwm qhov yuav luag dawb, qee zaum nrog kev sib koom me me.

Hauv 1 lub tshuaj ntawm cov tshuaj sib xyaw - 40 mg ntawm lub ntsiab tseem ceeb ntawm telmisartan thiab 12,5 mg ntawm hydrochlorothiazide diuretic.

Ntu Cheebtsam puav leej siv:

• mannitol
• lactose (mis nyuj qab zib),
• povidone
• meglumine
• magnesium stearate,
• sodium hydroxide
• polysorbate 80,
• zas E172.

Hauv 1 lub tshuaj ntawm cov tshuaj sib xyaw - 40 mg ntawm lub ntsiab tseem ceeb ntawm telmisartan thiab 12,5 mg ntawm hydrochlorothiazide diuretic.

Ntsiav tshuaj ntawm 6, 7 lossis 10 pcs. muab tso rau hauv cov hlwv uas ua los ntawm aluminium ntawv ci thiab polymer zaj duab xis. Ntim hauv cardboard thawv 2, 3 lossis 4 blisters.

Pharmacological kev txiav txim

Cov tshuaj ua rau muaj txiaj ntsig kho ob qho: hypotensive thiab diuretic. Txij li cov qauv tshuaj ntawm cov tshuaj tseem ceeb ntawm cov tshuaj zoo ib yam li cov qauv ntawm hom 2 angiotensin, telmisartan tshem tawm cov tshuaj no los ntawm kev sib txuas nrog cov leeg ntshav thiab ua kom nws cov yeeb yam ntev.

Nyob rau tib lub sijhawm, kev tsim cov tshuaj dawb aldosterone yog tshuaj tiv thaiv, uas tshem cov poov tshuaj hauv lub cev thiab khaws cov ntsev, uas ua rau kom muaj suab nrov vascular ntau dua. Nyob rau tib lub sijhawm, cov haujlwm ntawm renin, ib qho enzyme uas tswj ntshav siab, tsis tau raug txwv. Vim li ntawd, qhov nce ntawm cov ntshav siab nres, nws qhov tseem ceeb txo qis zuj zus.

Tom qab 1.5-2 teev tom qab noj cov tshuaj, hydrochlorothiazide pib ua kom nws cov nyhuv. Lub sijhawm ntsuas ntawm lub diuretic sib txawv ntawm 6 mus rau 12 teev. Nyob rau tib lub sijhawm, qhov ntau ntawm cov ntshav ncig ua kom tsawg, cov khoom ntawm aldosterone nce, qhov kev ua si renin nce ntxiv.

Cov kev sib xyaw ua ke ntawm telmisartan thiab ib qho diuretic ua rau ntau cov txiaj ntsig antihypertensive ntau dua li cov nyhuv ntawm cov hlab ntsha ntawm lawv txhua tus zuj zus. Thaum kho nrog cov tshuaj, cov tsos mob ntawm myocardial hypertrophy yog qhov tsawg dua, kev tuag yog txo qis, tshwj xeeb tshaj yog rau cov neeg laus cov neeg mob ntshav siab.

Thaum kho nrog tshuaj, qhov tshwm sim ntawm myocardial hypertrophy yog txo qis.

Kev sib xyaw ntawm telmisartan nrog hydrochlorothiazide tsis hloov pauv chaw muag tshuaj ntawm cov tshuaj yeeb dej caw. Lawv tag nrho cov bioavailability yog 40-60%. Cov tshuaj ua kom nquag plias ntawm cov tshuaj yog nqus tawm sai sai ntawm lub plab zom mov. Qhov siab tshaj plaws ntawm telmisartan txuam nrog hauv cov ntshav plasma tom qab 1-1.5 teev yog 2-3 zaug qis dua hauv txiv neej dua li ntawm poj niam. Cov metabolism hauv ib nrab tshwm sim hauv daim siab, cov tshuaj no tawm hauv cov quav. Hydrochlorothiazide tshem tawm ntawm lub cev yuav luag tsis hloov nrog cov zis.

Kev ntsuas rau siv

• nyob rau hauv kev kho mob ntawm kev mob ntshav siab ntawm thawj thiab theem nrab, thaum kho nrog telmisartan lossis hydrochlorothiazide ib leeg tsis muab qhov txiaj ntsig xav tau,
• txhawm rau tiv thaiv kom tsis txhob muaj mob nyuaj rau cov hlab plawv pathologies rau cov neeg laus dua 55-60 xyoo,
• txhawm rau tiv thaiv kom tsis txhob muaj teeb meem rau cov neeg mob ntshav qab zib hom II (non-insulin-tiv thaiv) nrog kev puas tsuaj rau cov khoom hauv nruab nrog los ntawm tus kab mob hauv qab.

Cov Yuav Tsum Tau Ua

Cov laj thawj rau kev txwv kev kho mob nrog Telsartan:

• hypersensitivity rau lub active tshuaj ntawm yeeb tshuaj,
• mob raum tsis zoo
• noj Aliskiren hauv cov neeg mob raum tsis ua haujlwm, ntshav qab zib,
• decompensated daim siab ua haujlwm,
• kua tsib leeg tav kev,
• lactase deficiency, lactose tsis txaus ntseeg,
• hypercalcemia,
• hypokalemia
• cev xeeb tub thiab lactation
• cov me nyuam hnub nyoog qis dua 18 xyoo

Kev ceev faj yuav tsum tau ua yog tias cov kab mob hauv qab no lossis kab mob pathological pom hauv cov neeg mob:

• txo qis hauv cov ntshav ncig,
• stenosis ntawm lub raum hlab ntsha, lub plawv nres,
• lub plawv dhia tsis zoo
• mob siab me,
• mob ntshav qab zib
• mob gout
• adrenal Cortical adenoma,
• lub qhov muag kaw lub ntsej muag daj,
• lupus erythematosus.

Yuav ua li cas coj Telsartan 40

Kev siv tshuaj: cov tshuaj noj txhua hnub ntawm lub qhov ncauj ua ntej lossis tom qab noj mov, 1 ntsiav tshuaj, uas yuav tsum tau ntxuav nrog me me ntawm cov dej. Qhov siab tshaj plaws niaj hnub noj tshuaj rau cov mob hnyav ntawm cov ntshav siab yog txog 160 mg. Nws yuav tsum tau yug hauv siab: qhov pom kev kho kom zoo tsis tshwm sim sai, tab sis tom qab 1-2 lub hlis ntawm kev siv tshuaj.

Kev siv tshuaj: cov tshuaj noj txhua hnub ntawm lub qhov ncauj ua ntej lossis tom qab noj mov, 1 ntsiav tshuaj, uas yuav tsum tau ntxuav nrog me me ntawm cov dej.

Cov neeg mob uas muaj tus kab mob no feem ntau tau sau tseg los tiv thaiv teeb meem ntawm lub plawv, ob lub raum, thiab qhov muag. Rau ntau tus neeg mob ntshav qab zib nrog kub siab, kev sib txuas ntawm Telsartan nrog Amlodipine yog qhia. Qee qhov xwm txheej, kev saib xyuas ntawm uric acid hauv cov ntshav nce siab, gout nce ntxiv. Nws yuav tsim nyog los kho lub koob tshuaj ntawm cov tshuaj hypoglycemic.

Sab Cuam Los Ntawm Telsartan 40

Qhov txheeb cais ntawm qhov tshwm sim tsis zoo rau cov tshuaj no thiab rau telmisartan noj tsis muaj hydrochlorothiazide yog kwv yees li qub. Kev nquag ntawm ntau cov kev mob tshwm sim, piv txwv li, kev cuam tshuam ntawm cov nqaij mos trophism, cov metabolism (hypokalemia, hyponatremia, hyperuricemia), tsis cuam tshuam rau qhov ntau npaum li cas, tub los ntxhais thiab hnub nyoog ntawm cov neeg mob.

Cov tshuaj uas tsis tshua muaj mob yuav ua rau:

• qhov ncauj qhuav
• dyspepsia
• flatulence
• mob plab
• cem quav
• zawv plab
• ntuav
• mob plab.

Cov tshuaj tiv thaiv rau cov tshuaj xws li:

• txo qis hauv hemoglobin qib,
• anemia
• eosinophilia
• thrombocytopenia.

Cov kev mob tshwm sim heev yog kiv taub hau. Tsis tshua muaj tshwm sim:

• paresthesia (kev nkag siab ntawm cov nqaj ntoo goosebumps, tingling, hlawv kev mob),
• pw tsis tsaug zog los sis, hloov pauv, nkees nkees,
• qhov muag plooj
• ntxhov siab yam mob
• kev nyuaj siab
• syncope (cia li ntse tsis muaj zog), tsaus muag.

• muaj zog concentration ntawm uric acid, creatinine hauv ntshav ntshav,
• nce kev ua haujlwm ntawm cov enzyme CPK (creatine phosphokinase),
• mob raum tsis ua haujlwm
• mob txeeb zig, suav nrog cystitis.

Tsis tshua muaj kev phiv tshuaj:

• mob hauv siab
• txog siav
• khaub thuas zoo li mob khaub thuas, mob ntsws, mob pharyngitis, mob ntsws,
• mob ntsws, mob ntsws ntsws qhuav.

• erythema (mob tawv nqaij liab)
• o tuaj
• ua pob
• khaus
• nce tawm hws,
• urticaria
• dermatitis
• eczema
• angioedema (tsis tshua muaj neeg).

Telsartan tsis cuam tshuam loj heev cuam tshuam rau kev ua haujlwm ntawm qhov chaw mos.

• arterial lossis orthostatic hypotension,
• txhav, tachycardia.

Cov kev mob tshwm sim hauv qab no ntawm cov leeg ua haujlwm yog:

• cramping, mob hauv cov leeg, leeg, pob qij txha,
• cramps, feem ntau nyob rau hauv qis ceg,
• lumbalgia (mob mob nraub qaum).

Hauv qab ntawm qhov tshuaj nyob rau hauv tsawg zaus, cov hauv qab no tuaj yeem pom:

• kev txawv txav hauv lub siab,
• nce kev ua si ntawm cov enzymes uas ua los ntawm lub cev.

Anaphylactic shock tsis tshua muaj tshwm sim.

Txij li kev pheej hmoo ntawm kev nkees nkees, kiv taub hau tsis tuaj yeem tswj hwm tau, ceeb toom thaum tsav tsheb, ua haujlwm ua haujlwm uas xav tau kev saib xyuas ntau tshaj plaws.

Cov lus qhia tshwj xeeb

Nrog lub cev tsis muaj ntsev ntau hauv cov ntshav lossis ib qho ntshav tsis txaus ntawm lub cev ntshav, pib ntawm kev kho tshuaj yuav tuaj yeem nrog kev poob qis hauv cov ntshav siab. Mob hypotension mob feem ntau muaj rau cov neeg mob raum voos ntshav liab, mob plawv, thiab plawv nres tsis zoo. Ib qho kev poob siab tseem ceeb tuaj yeem ua rau mob stroke lossis myocardial infarction.

Siv cov tshuaj nrog ceev faj thiab nrog stenosis ntawm mitral lossis aortic valve.

Hauv cov neeg mob ntshav qab zib, mob ntshav qab zib tsawg tuaj yeem ua tau. Nws yog ib qho tsim nyog yuav tsum tau nquag soj ntsuam cov qib ntawm cov piam thaj hauv cov ntshav, kho lub koob tshuaj ntawm cov kab mob hypoglycemic.

Hauv cov neeg mob ntshav qab zib, mob ntshav qab zib tsawg tuaj yeem ua tau.

Hydrochlorothiazide ua ib feem ntawm Telsartan muaj peev xwm nce qhov siab ntxiv ntawm cov tshuaj lom neeg nitrogen ntau ntxiv rau qhov ua rau lub raum tsis ua haujlwm, zoo li ua rau muaj kev txhim kho ntawm cov mob myopia, lub kaum ntse ntse-kaw lub ntsej muag.

Lub sijhawm ntev siv cov tshuaj feem ntau ua rau hyperkalemia. Nws yog qhov yuav tsum tau saib xyuas cov ntsiab lus ntawm cov roj ntsha hauv ntshav cov ntshav.

Qhov kev ua haujlwm tsis meej ntawm kev siv yeeb tshuaj tsis ua rau kev txhim kho ntawm kev thim rov qab.

Nrog tus thawj hyperaldosteronism, kho tus mob ntawm Telsartan yog xyaum tsis tuaj.

Kev siv yeeb tshuaj yog contraindicated thaum xeeb tub thiab pub niam mis.

Cov tshuaj tsis yog tsim los siv rau cov neeg mob qis dua 18 xyoo.

Thaum tsis muaj cov kab mob concomitant hnyav heev, tsis tas yuav hloov tshuaj ntxiv.

Qhov koob tshuaj yuav tsis haum rau cov neeg mob raum tsis ua hauj lwm mob hnyav, suav nrog tab tom ua cov txheej txheem hemodialysis.

Raws li cov txiaj ntsig tau los ntawm kev tshawb fawb ntau yam hauv cov neeg mob uas muaj me me mus rau lub cev tsis haum lub siab, koob tshuaj txhua hnub cov tshuaj yuav tsum tsis pub tshaj 40 mg.

Raws li cov txiaj ntsig tau los ntawm kev tshawb fawb ntau yam hauv cov neeg mob uas muaj me me mus rau lub cev tsis haum lub siab, koob tshuaj txhua hnub cov tshuaj yuav tsum tsis pub tshaj 40 mg.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog rau kev siv ua ke nrog lwm cov tshuaj uas txo cov ntshav siab, cov tshuaj kho tau zoo dua rau lawv cov nyhuv kho.

Thaum noj Telsartan nrog Digoxin, qhov tseem ceeb ntawm cov mob glycoside nce siab, yog li ntawd, kev saib xyuas ntawm nws cov ntshav ntau yog tsim nyog.

Yuav kom zam dhau hyperkalemia, cov tshuaj yuav tsum tsis txhob ua ke nrog cov neeg sawv cev uas muaj cov poov tshuaj.

Qhov yuav tsum tau saib xyuas ntawm cov concentration ntawm lithium hauv cov ntshav thaum siv cov tshuaj uas muaj cov sib txuas ntawm cov hlau alkali no, vim tias Telmisartan ua rau lawv muaj tshuaj lom ntau.

Glucocorticosteroids, Aspirin thiab lwm yam tshuaj uas tsis yog tshuaj steroidal txo cov nyhuv antihypertensive ntawm cov tshuaj.

NSAIDs ua ke nrog telmisartan tuaj yeem ua rau lub raum khiav tsis zoo.

Thaum kho nrog ib qho tshuaj, koj yuav tsum tsis txhob haus dej cawv ntawm ib qho dab tsi.

Telsartan tuaj yeem hloov nrog cov tshuaj hauv qab no nrog cov nyhuv zoo:

Kev txheeb xyuas txog Telsartan 40

Maria, 47 xyoo, Vologda

Cov tshuaj zoo heev thiab zoo li muaj kev nyab xeeb tshaj plaws ntawm ntau txoj kev kho rau tus mob vascular. Nws tseem ceeb tias qhov zoo tshuaj no yog tsim tawm hauv Is Nrias teb, thiab tsis yog hauv lub teb chaws Yelemees lossis Switzerland. Cov kev mob tshwm sim me. Qee zaum lub siab tsuas yog thab kuv, tab sis nws tau ua rau kuv mob ntev thaum kuv tsis tau noj Telsartan tseem.

Vyacheslav, 58 xyoo, Smolensk

Kuv muaj keeb kwm ntev ntev ntawm kev kub siab. Ntxiv rau lub raum tsis ua haujlwm. Yuav ua li cas npaj nyob ib leeg tsis tas yuav tsum tau noj rau ntau xyoo ntawm kev kho mob! Tab sis qee zaus lawv yuav tsum tau hloov, vim hais tias lub cev tau siv rau nws, thiab tom qab ntawd lawv tsum tseg ua ib yam li yav dhau los. Tsis ntev no kuv tau noj Telsartan. Cov lus qhia rau nws muab ib daim ntawv teev cov kev mob tshwm sim, tab sis tsis muaj ib qho ntawm lawv tau tshwm sim. Cov tshuaj zoo uas stably tuav siab. Qhov tseeb yog me ntsis kim.

Irina, 52 xyoo, Yekaterinburg

Thawj thawj zaug, kws kho mob hais tias Amlodipine yuav tsum noj, tab sis tom qab ib lis piam nws ob txhais ceg pib o tuaj. Tus kws kho mob hloov nws nrog Enap - tsis ntev ib qho hnoos pib txhawm chim kuv. Tom qab ntawd kuv yuav tsum hloov mus rau Telsartan, tab sis nws tau muab tawm tias kuv muaj tus neeg tsis kam rau nws. Muaj xeev siab, ces tawv nqaij tawm pob. Kuv Rov mus kuaj mob dua. Thiab tsuas yog thaum tus kws kho mob tau hais kom ua Concor tau ua txhua yam poob rau hauv qhov chaw. Kuv tsis muaj teeb meem nrog cov tshuaj no. Yog li nws yog ib qho tseem ceeb heev uas tus kws kho mob xaiv cov tshuaj uas yog rau koj.

Cov ntaub ntawv dav dav txog cov tshuaj

Kev nqis tes ntawm cov tshuaj suav nrog tsis tsuas yog txo qis ntshav siab, tab sis kuj muaj xws li txo cov load ntawm lub plawv, kev tiv thaiv ntawm cov kabmob hauv lub cev (retina, vascular endothelium, myocardium, hlwb, raum), kev tiv thaiv ntawm cov teeb meem (mob plawv, mob hlab ntsha tawg), tshwj xeeb nrog muaj cov kev pheej hmoo ntxiv (nce ntshav viscosity, ntshav qab zib mellitus).

Telsartan txo cov tshuaj tiv thaiv insulin, nce kev siv cov piam thaj, kho cov dyslipidemia (txo cov LDL "kev phom sij" thiab nce "HDL" muaj txiaj ntsig).

Cov pab pawg tshuaj, INN, thaj tsam

Telsartan yog ib qho kev xaiv cov tshuaj angiotensin-II receptor blocker (AT1). Telsartan N - rau kev sib txuam tshuaj, ua ke los ntawm cov tshuaj tiv thaiv angiotensin-II receptors (AT1) nrog cov tshuaj ua kom lub cev tseem ceeb thiab cov nyhuv antidiuretic ntawm hydrochlorothiazide. Los ntawm cov qauv tshuaj, nws belongs rau biphenyl netetrazole tebchaw. Nws yog cov tshuaj nquag. Ib qho tsis muaj kev sib tw ntawm cov yeeb ncuab uas sib khi rau receptors irreversibly.

Cov nyhuv ntawm angiotensin II receptor antagonists

INN: Telmisartan / Telmisartan. Siv hauv cardiology hauv kev sib ntaus tawm tsam nce systolic thiab diastolic siab, lub plawv tsis ua haujlwm. Telsartan N yog siv rau qhov tsis muaj txiaj ntsig ntawm kev kho mob monotherapy nrog tshuaj ntawm lwm pab pawg.

Daim ntawv tso tawm thiab tus nqi rau cov tshuaj, nruab nrab hauv Lavxias

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntsiav tshuaj, hauv ob qhov tshuaj - 40 thiab 80 mg. Hauv plawv thawv ntawv 3 blisters ntawm 10 ntsiav tshuaj. Cov ntsiav tshuaj muaj lub puab ntev zoo li lub ntsej muag, convex ntawm ob sab, tsis muaj lub plhaub, daus-dawb hauv cov xim, muaj ib txoj kab hauv nruab nrab ntawm ib sab, ntawm ob sab uas muaj ob lub embossments - "T thiab L", qhov ntau npaum li cas tau qhia nyob rau sab nraub qaum.

Cov lus hauv qab no qhia cov nqi hauv rubles rau cov tshuaj:

Lub rooj qhia cov khoom tseem ceeb ntawm cov tshuaj:

Pharmacodynamics thiab pharmacokinetics

Telsartan yog xaiv hom 1 angiotensin-II receptor inhibitor. Cov receptors no nyob rau ntau cov nqaij hauv lub cev, tshwj xeeb tshaj yog cov leeg ntawm cov hlab ntsha, myocardium, cortical txheej ntawm cov qog adrenal, lub ntsws, thiab qee qhov chaw hauv lub hlwb. Angiotensin-II yog qhov muaj txiaj ntsig zoo tshaj plaws peptide tshuaj ntawm renin-angiotensin-aldosterone system (RAAS).

Los ntawm cov txais ntawm hom no, cov teebmeem hauv qab no yog pom tau hais tias ncaj qha lossis tsis ncaj rau kev ua rau kom muaj kev nrawm nrawm, tab sis feem ntau tau txiav txim siab ntxiv ntshav siab. Qhov kev txiav txim ntawm Telsartan yog tsom ntawm lawv txo, uas yog, nws tau los thaiv lossis tiv thaiv:

• nce nyob rau hauv tag nrho peripheral tsis kam ntawm cov hlab ntsha ntawm txawv caliber,
• vasoconstriction ntawm cov hlab ntsha ntawm glomeruli ntawm ob lub raum thiab nce hauv hydraulic siab hauv lawv,
• kev tuav lub cev ntawm cov kua dej ntau dhau: nce nqus ntawm sodium thiab dej hauv qhov ze ntawm tubules, kev tsim khoom ntawm aldosterone,
• kev tso tawm ntawm cov tshuaj tiv thaiv antidiuretic, endothelin-1, renin,
• kev ua kom muaj lub siab ntsws-adrenal system thiab tso tawm ntawm catecholamines vim kev nkag mus los ntawm cov ntshav-hlwb teeb meem,

Ntxiv nrog rau RAAS systemic, kuj tseem muaj cov ntaub so ntswg (hauv zos) RAA cov tshuab hauv ntau cov nqaij thiab cov kabmob. Lawv kev ua haujlwm ua rau lub cev muaj txiaj ntsig ntev ntev ntawm angiotensin, uas ua rau muaj kev tawm tsam ntawm endothelium thiab cov leeg txheej ntawm cov hlab ntshav, cardiomyocyte hypertrophy, myocardial remodeling, myofibrosis, atherosclerotic vascular puas tsuaj, nephropathy, thiab lub hom phiaj ntawm kev puas tsuaj.

Ib lub ntsej muag ntawm Telsartan yog tias nws xaiv txoj hlua khi nkaus xwb rau thawj hom tshuaj angiotensin-II rau lub sijhawm ntev thiab tshem tawm qhov tsis zoo ntawm angiotensin, tsuas yog "tsis pub" nws rau cov receptors.

Qhov kev txiav txim kav los ntawm 24 txog 48 teev. Qhov ua kom txo qis rau hauv ntshav tshwm sim ntseeg siab, maj mam dhau ob peb teev. Piv nrog tib ACE inhibitors, uas ntev tau pom tias yog ib pawg zoo tshaj plaws ntawm kev siv tshuaj tiv thaiv kab mob, cov txheej txheem hauv qab no yog qhov tseeb meej ntawm cov tshuaj:

• ua tiav kev thaiv ntawm qhov tsis zoo ntawm angiotensin (ACE inhibitors tsis tau tag nrho thaiv),
• paub qhov tseeb ntawm cov txiaj ntsig zoo ntawm angiotensin los ntawm kev txais ntawm hom AT2 (ACE inhibitors, ntawm qhov tsis sib thooj, txo),
• tsis inhibit kinase, vim qhov tshwm sim uas tsis muaj kev cuam tshuam ntawm bradykinin thiab, vim li ntawd, qhov tshwm sim tsis zoo cuam tshuam nrog nws (hnoos, angioedema, cov nyhuv embiotoxic, nce prostacyclin synthesis),
• organoprotection.

Receptors ntawm hom thib ob tau kawm tsis zoo, tab sis cov kws tshawb fawb muaj peev xwm tsim tau tias muaj ntau ntawm lawv nyob rau lub sijhawm embryonic, uas yuav qhia tau tias lawv cov txiaj ntsig ntawm kev loj hlob ntawm tes thiab kev loj hlob. Tom qab, lawv cov lej tsawg dua. Qhov kev txiav txim los ntawm cov receptors yog qhov txawv txav ntawm qhov kev ua ntawm thawj hom ntawm receptors. Qhov ua tau zoo los ntawm AT2 receptors yog raws li hauv qab no:

• kev kho cov ntaub so ntswg hauv qib ntawm tes,
• vasodilation, muaj zog ua ke ntawm TSIS-yam,
• inhibition ntawm kev loj hlob ntawm tes, loj hlob,
• inhibition ntawm cov mob hypertrophy.

Telsartan H muaj ntau dua cov nyhuv antihypertensive, uas muaj cov hydrochlorothiazide - lub voj diuretic uas txo cov reabsorption ntawm sodium ion thiab dej los ntawm lub raum, muab cov nyhuv antidiuretic. Nws tseem muab qhov yooj yim ntawm kev siv: tsis txhob siv ntau lub ntsiav tshuaj, nws txaus los noj nws ib zaug txhua 24 teev, uas yuav muab tau cov txiaj ntsig zoo.

Nrog kev siv txuas ntxiv, kev kho mob nyhuv ntawm telmisartan tshwm sim hauv thaj tsam li 3-5-7 lub lis piam. Nws sib npaug txo qhov systolic thiab diastolic siab. Tsis muaj ib qho kev tshem tawm tus mob ntxiv: thaum koj tsum tsis noj tshuaj, lub siab rov mus rau cov lej siab dua rau ob peb hnub, tsis muaj qhov ua kom tsis muaj zog ntxiv thaum koj nres.

Thaum noj ib lub os, qhov siab tshaj plaws nyob rau hauv cov ntshav tau mus txog tom qab 1-2 teev. Bioavailability yog 60%, yog nqus tau sai. Cov tshuaj tuaj yeem noj tau txhua lub sijhawm, tsis hais txog khoom noj khoom haus. 98.6% lossis ntau dua khi rau cov plasma protein, ntxiv rau khi rau cov ntaub so ntswg (qhov ntim ntawm kwv yees li 510 l).

Qhov kev xav hauv cov ntshav ntawm cov poj niam siab dua li ntawm txiv neej, qhov no tsis cuam tshuam rau qhov siv tau. Txog 98% ntawm telmisartan yog tawm hauv qhov biliary, tus menyuam yaus - nrog tso zis. Nws yog metabolized los ntawm conjugation, uas ua rau muaj qhov tsim ntawm acetylglucoronide nyob rau hauv ib daim ntawv tsis muaj zog. Kev tshem tawm tag nrho yog ntau dua 1499 ml / min. Kev tshem tawm ib nrab-lub neej yog ntau tshaj 19 teev. Hydrochlorothiazide tsis yog metabolized thiab raug tawm hauv nws daim ntawv dawb los ntawm cov zis.

Pharmacokinetics tsis hloov pauv raws li poj niam txiv neej thiab hnub nyoog. Hauv cov neeg mob uas lub cev tsis ua haujlwm ntawm lub zog ntawm qhov tsis txaus, cov tshuaj lom hauv cov ntshav muaj ntau zaus ntau dua li ib txwm muaj, nrog hemodialysis, ntawm qhov tsis tooj, qis dua, txawm hais tias qhov tseeb tseem muaj feem cuam tshuam nrog ntshav protein. Thaum lub cev tsis ua haujlwm ntawm daim siab tsis tseem ceeb, kev ua kom muaj zog ntawm bioavailability nce mus txog 98%.

Kev taw qhia thiab contraindications

Cov cim tseem ceeb rau kev siv Telsartan:

• ntshav siab
• kev tiv thaiv kab mob plawv thiab leeg,
• txo ntawm CVD kev puas tsuaj rau cov neeg mob uas muaj ntshav qab zib hom 2 mob ntshav qab zib nrog kev puas tsuaj rau cov kabmob plab hnyuv siab raum,
• atherosclerosis vascular mob heev.

• ua xua rau kev sib xyaw ntawm cov tshuaj,
• Thib 2 thiab thib peb lub cev xeeb tub, pub niam mis,
• muaj hnub nyoog me
• thaiv ntawm biliary system,
• kev puas tsuaj rau lub siab ua haujlwm tsis zoo,
• refractory hypokalemia thiab hypercalcemia,
• mob gout
• siv tib txhij nrog Aliskiren hauv ntshav qab zib.

Vim yog cov kev tshawb fawb tsis txaus, cov tshuaj yuav tsum tsis txhob muab rau cov menyuam yaus hnub nyoog qis dua 18 xyoo. Nws yog nruj me ntsis txwv tsis pub noj cov tshuaj thaum cev xeeb tub, tshwj xeeb tshaj yog nyob rau lub sijhawm thib 2 thiab thib peb, txij li cov tshuaj muaj cov nyhuv fetotoxic siab: qhov txo qis hauv txoj haujlwm ntawm excretory system, qeeb hauv ossification, thiab oligohydramnios.

Hauv cov menyuam mos yug tshiab, muaj: cov ntsiab lus ntawm cov poov tshuaj ntau ntxiv, txo qis qhov siab, tsis txaus los ntawm lub zog ntawm qhov system rov qab. Sartans yuav tsum tau txiav txuas ntxiv thiab hloov nrog lwm pab pawg ntawm cov tshuaj. Nco ntsoov ua tib zoo saib xyuas tus menyuam thiab leej niam.

Cov lus qhia rau kev siv

Qhov tshuaj no tau noj ib zaug txhua 24 teev nyob rau tib lub sijhawm, tsis hais noj mov li cas. Haus dej kom ntau. Raws li cov lus qhia rau kev siv Telsartan, qhov kev pib koob tshuaj yog 20 mg, tom qab ntawd cov koob tshuaj yuav raug maj mam nce ntxiv. Kev noj tshuaj ntawm 40 mg feem ntau kho tau zoo. Hauv cov neeg mob "pheej", koj tuaj yeem nce cov tshuaj rau 80 mg rau ib hnub, tab sis tsis ntau ntxiv. Qhov tsuas tshuaj no yog qhov ntau tshaj plaws.

Raws li lwm txoj hauv kev tsis ua tiav ntawm kev kho mob monotherapy, kev sib xyaw ntawm angiotensin receptor blockers thiab diuretic raug siv, cov tshuaj Telsartan N.

Nws tsis pom zoo kom sib xyaw ua ke noj Telsartan nrog cov poov tshuaj npaj, ACE inhibitors, potassium-sparing saluretics, NSAIDs, Heparin, immunosuppressants - vim tias qhov no tuaj yeem ua rau muaj kev nce siab ntau nyob hauv potassium ions hauv lub cev. Concomitant siv nrog lithium npaj kuj tseem tsis pom zoo, vim tias qhov no tuaj yeem ua rau nws cov kuab lom ntau dhau.

Cov neeg mob siab siab feem ntau xav tias Telsartan thiab Diuver tuaj yeem noj tib lub sijhawm. Cov kev tshawb fawb pom tau tias kev sib koom ua ke ntawm telmisartan thiab torasemide, uas yog cov khoom tseem ceeb ntawm cov tshuaj no, ua rau txo qis ntshav siab.

Siv cov tshuaj sib xyaw ua ke nrog ceev faj, vim tias muaj kua ntau dhau ntawm lub cev tuaj yeem ua rau hypotension. Ua ntej siv ib qho yeeb tshuaj twg, thiab tseem ntau dua yog li lawv cov kev sib xyaw ua ke, koj yuav tsum sab laj nrog koj tus kws kho mob.

Muaj cov tshuaj tsis haum thiab noj tshaj

Kev noj ntau dhau tuaj yeem hem kev tsis haum hauv qab no:

• hypotension
• tachycardia
• Cov tsos mob dyspeptic
• lub raum tsis ua hauj lwm.

Cov tshuaj muaj ib qho tsis tseem ceeb ntawm cov kev mob tshwm sim, uas kuj tsis tshua muaj txaus:

• syncope,
• arrhythmia, tachycardia,
• kiv taub hau
• ntsug
• parasthesia
• dyspeptic tshwm sim.

Lub ntsiab hloov pauv rau cov tshuaj Telsartan:

• Mikardis.
• Telzap
• Telmista.
• Telpres.
• Tshuab luam ntawv.
• Tanidol.
• Cov no.
• Hipotel.

Qhov tseem ceeb tshaj plaws sib txawv ntawm cov tshuaj no yog tus nqi, lub teb chaws ntawm tseem yog qhov sib txawv, uas cuam tshuam qhov zoo ntawm kev ntxuav ntawm cov sib xyaw ntawm cov tshuaj. Los ntawm cov khoom, cov tshuaj no zoo ib yam. Tab sis cov tshuaj tiv thaiv zoo tshaj plaws yog Mikardis, Praitor thiab Telpres.

Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob

Feem ntau, ob tus kws tshaj lij thiab cov neeg mob tau muab ntau qhov kev txheeb xyuas zoo txog tshuaj, ntawm no yog qee qhov ntawm lawv:

Alexander Dmitrievich, kws kho plawv, hais tias: "Cov tshuaj muaj cov lus tshaj tawm thiab txo txoj hauv siab siab. Nws cov nyhuv kav sijhawm ntev.

Ib qho kev ua yeeb yam thiab pom tseeb meej yog nws cov kev xaiv inhibition ntawm cov teeb meem los ntawm angiotensin thaum tswj qhov zoo. Txaus noj ib ntsiav tshuaj ib hnub. Nws yooj yim heev rau xaiv thiab kho lub koob tshuaj. Cov tshuaj ntawm cov tub ntxhais hluas tiam tam sim no nrog qhov tsawg heev ntawm kev phiv. "

Raws li cov ntaub ntawv paub ntawm cov tshuaj, peb tuaj yeem ntseeg siab tau hais tias niaj hnub no nws yog ib qho ntawm cov tshuaj tiv thaiv zoo tshaj plaws. Xaiv yam tshem tawm qhov tsis zoo thiab tswj hwm qhov muaj txiaj ntsig zoo ntawm lub plawv kev mob plawv thiab lub cev tag nrho.

Lub Npe Tsis Muaj Npe International

Cov tshuaj INN - Telmisartan.

Hauv qhov kev faib tawm thoob ntiaj teb ntawm ATX, cov tshuaj muaj cai C09CA07.

Kev siv Telsartan yog qhia rau ntau tus mob pathological, nrog los ntawm kev nce ntshav nce siab.

Cov Tshuaj Pharmacokinetics

Thaum noj tshuaj pab, nws cov tshuaj tiv thaiv kom sai. Bioavailability ncav cuag 50%. Qhov siab tshaj plaws ntawm cov tshuaj hauv cov ntshav hauv cov txiv neej thiab poj niam tau ua tiav 3 teev tom qab kev tswj hwm. Cov tshuaj khi rau cov ntshav protein. Cov tshuaj metabolism hauv cov qib qis nrog kev koom tes ntawm glucuronic acid. Metabolites ua rau cov quav nyob hauv 20 teev.

Nrog saib xyuas

Kev kho mob nrog telsartan yuav tsum tau ceev faj heev ntawm lub raum leeg mob stenosis. Ntxiv rau, cov neeg mob mitral thiab aortic valve stenosis thaum kho nrog Telsartan xav tau kev saib xyuas tshwj xeeb los ntawm cov neeg kho mob. Kev saib xyuas tshwj xeeb yuav tsum tau noj nrog hypokalemia thiab hyponatremia. Nws yog qhov ua tau los siv cov khoom nkaus xwb nyob rau hauv kev saib xyuas zoo ntawm cov kws kho mob thiab yog tias muaj tus neeg mob lub keeb kwm ntawm lub raum hloov ntshav.

Nrog ntshav qab zib

Rau cov neeg mob uas muaj mob ntshav qab zib hom 2, cov tshuaj tau tawm hauv lub hnub pib ntawm 20 mg. Hauv yav tom ntej, kev noj tshuaj txhua hnub tuaj yeem nce ntxiv txog 40 mg.

Noj mov tsis cuam tshuam rau kev nqus ntawm cov tshuaj nquag ntawm cov tshuaj.

Los ntawm genitourinary system

Qee tus neeg mob cystitis. Muaj qee zaus, tawm tsam keeb kwm ntawm kev mob hnyav ntawm cov kab mob genitourinary, sepsis yuav tshwm sim.

Qee tus neeg mob cystitis.

Ntawm ib sab ntawm daim siab thiab cov hnyuv

Nws muaj tsawg kawg hauv kev kho mob Telsartan uas muaj kev ua txhaum ntawm daim siab thiab cov mob plab.

Nws muaj tsawg kawg hauv kev kho mob Telsartan tias muaj kev ua txhaum ntawm daim siab ua haujlwm.

Yog hais tias tus neeg mob tau mob hypersensitivity, kev ua xua tuaj yeem tshwm sim, qhia raws li daim tawv nqaij ua pob khaus thiab khaus, zoo li Quincke's edema.

Siv thaum cev xeeb tub thiab lactation

Kev kho mob nrog Telsartan rau cov poj niam hauv txhua qhov trimesters ntawm cev xeeb tub yog qhov tsis tuaj yeem. Nws tsis pom zoo kom siv cov tshuaj rau kev pub niam mis.

Kev kho mob nrog Telsartan rau cov poj niam hauv txhua qhov trimesters ntawm cev xeeb tub yog qhov tsis tuaj yeem.

Daim ntawv thov rau lub siab ua haujlwm tsis zoo

Cov tshuaj yuav tsum tsis txhob siv rau hauv kev kho mob rau cov neeg muaj kab mob siab, nrog kev cuam tshuam ntawm cov hlab thiab cov mob cholestasis.

Cov tshuaj yuav tsum tsis txhob siv rau hauv kev kho mob rau cov neeg muaj kab mob siab, nrog kev cuam tshuam ntawm cov hlab thiab cov mob cholestasis.

Cawv tau zoo

Koj yuav tsum tsis kam haus cawv thaum kho mob Telsartan.

Koj yuav tsum tsis kam haus cawv thaum kho mob Telsartan.

Telsartan cov ntsiab lus uas muaj cov nyhuv kho zoo sib xws: