Glidiab - cov lus qhia yuav ua li cas los hloov thiab nws tus nqi npaum li cas

Ib ntsiav tshuaj muaj

cov tshuaj heev - gliclazide hais txog 100% tshuaj 80 mg,

zam txim: lactose monohydrate, microcrystalline cellulose, qos yaj ywm hmoov txhuv, hypromellose, magnesium stearate, talc, sodium carboxymethyl hmoov txhuv nplej siab.

Cov ntsiav tshuaj yog xim dawb los yog dawb nrog lub ntsej muag daj los yog creamy zas xim, tiaj-cylindrical nyob rau hauv cov duab, nrog ib tug bevel.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Kev tshem tawm yog qhov siab. Tom qab lub qhov ncauj ntawm 80 mg, lub sijhawm siab tshaj yog 4 teev, thiab qhov siab tshaj plaws ntshav plasma yog 2.2-8 -8g / ml. Kev sib txuas lus nrog cov protein plasma - 85-97%, cov khoom faib tawm - 0.35 l / kg. Kev sib luag plasma ntshav sib luag yog nce mus txog tom qab 2 hnub. Qhov kev tshem tawm ib nrab-lub neej yog 8-20 teev.Nws yog metabolized hauv daim siab, nrog rau kev tsim ntawm 8 metabolites. Tus nqi ntawm cov metabolite tseem ceeb hauv cov ntshav yog 2-3% ntawm tag nrho cov tshuaj ntawm cov tshuaj noj, nws tsis muaj hypoglycemic lub zog, tab sis nws muaj cov nyhuv ntawm microcirculation. Nws yog tawm los ntawm lub raum - 70% nyob rau hauv daim ntawv ntawm metabolites, tsawg dua 1% tsis hloov pauv, los ntawm cov hnyuv - 12% nyob rau hauv daim ntawv ntawm metabolites.

Cov Tshuaj Hauv Tshuaj

Tus neeg sawv cev ntawm tus mob ntshav qab zib ntau ntau, yog sulfonylurea derivative ntawm lub cim thib ob. Nws txhawb cov kua dej los ntawm cov kua dej zais pa, ua rau cov kua dej-insulin muaj txiaj ntsig ntawm cov kua nplaum thiab qhov rhiab ntawm cov ntaub so ntswg mus rau insulin.

Tsim kho kev ua ub no ntawm intracellular enzymes - nqaij hlav glycogen synthetase. Txo lub sijhawm ua ntu zus los ntawm lub sijhawm noj mov kom pib lub insulin secretion. Rov kho lub sijhawm thaum ntxov ntawm insulin secretion (tsis zoo li lwm yam sulfonylurea derivatives, piv txwv li, glibenclamide, uas cuam tshuam rau lub sijhawm thib ob ntawm kev zais). Ntxiv nrog rau cuam tshuam rau cov metabolism hauv kev ua kom yuag, nws cuam tshuam microcirculation. Nws txo qis postprandial hyperglycemia, txo cov platelet adhesion thiab kev sib sau ua ke, ncua kev txhim kho ntawm parietal thrombosis, normalizes vascular permeability thiab inhibits kev txhim kho ntawm microthrombosis thiab atherosclerosis, rov qab cov txheej txheem ntawm physiological parietal fibrinolysis, thiab tawm tsam cov tshuaj tiv thaiv ntau ntxiv rau vascular epinephrine nyob rau hauv cov ntaub ntawv. Txo cov kev loj hlob ntawm cov ntshav qab zib retinopathy nyob rau theem tsis-loj hlob, nrog rau cov ntshav qab zib uas muaj lub cev ntev nrog kev siv ntev, qhov tseem ceeb txo qis rau cov proteinuria tau sau tseg. Nws tsis ua rau muaj qhov nce hauv lub cev qhov hnyav, vim nws muaj lub luag haujlwm tseem ceeb ntawm cov tshuaj tiv thaiv thaum ntxov thiab tsis ua rau hyperinsulinemia, nws pab txo lub cev qhov hnyav hauv cov neeg mob rog, ua raws li kev noj zaub mov zoo. Nws muaj cov khoom ua rau anti-atherogenic, txo qis qhov kev tso tawm ntawm cov roj (cholesterol) hauv cov ntshav.

Tsuas tshuaj thiab tswj hwm

Sab hauv, thaum noj mov, qhov xav kom tau noj thawj zaug yog 40 mg (½ ntsiav tshuaj), qhov koob tshuaj txhua hnub yog 80 mg (1 ntsiav tshuaj), qhov nruab nrab txhua hnub yog 160 mg (2 ntsiav tshuaj hauv 2 koob, sawv ntxov thiab yav tsaus ntuj), qhov koob tshuaj txhua hnub yog 320 mg (4 ntsiav tshuaj hauv 2 faib ua ke - sawv ntxov thiab yav tsaus ntuj). Cov koob tshuaj nyob ntawm lub hnub nyoog, qhov mob hnyav ntawm cov chav kawm mob ntshav qab zib, cov ntsiab lus ntawm cov piam thaj hauv cov ntshav ntawm lub plab khoob thiab 2 teev tom qab noj mov.

Txhua qhov hloov pauv koob tshuaj tom qab tuaj yeem ua tom qab tsawg kawg ob lub lim tiam. Yog tias cov tshuaj tsis tiav, tom qab ntawv hnub ntxiv cov koob tshuaj yuav tsum tsis txhob muab ntxiv.

Hauv cov neeg mob laus lossis hauv lub raum tsis ua haujlwm ntawm qhov mob me mus rau mob hnyav me me (tshem tawm creatinine - 15-80 ml / min), cov tshuaj yog tshuaj rau hauv tib lub koob tshuaj.

Cov Yuav Tsum Muaj

hypersensitivity rau gliclazide lossis ntu cov tshuaj ntawm cov tshuaj, nrog rau lwm cov sulfonylurea derivatives

ntshav qab zib hom 1

mob ntshav qab zib precoma thiab coma

hepatic thiab / lossis lub raum tsis ua haujlwm

concomitant kho nrog miconazole

cev xeeb tub, lactation

cov menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo

Nrog saib xyuas

Cov neeg laus, tsis meej thiab / los yog tsis muaj zaub mov noj tsis txaus, cov kab mob hnyav ntawm cov hlab plawv (suav nrog rau cov hlab plawv, atherosclerosis), hypothyroidism, adrenal lossis pituitary tsis txaus, hypopituitarism, raum thiab / lossis daim siab tsis ua haujlwm, ntev glucocorticosteroid txoj kev kho, haus dej cawv , glucose-6-phosphate dehydrogenase deficiency, concomitant kho nrog phenylbutazone thiab danazole.

Sab sij huam

- Kev mob ntshav qog ntshav qab zib (hauv kev ua txhaum ntawm kev muab tshuaj thiab kev noj zaub mov tsis zoo)

- mob taub hau, kiv taub hau, nkees, tshaib plab, tawm hws, tsis muaj zog

- palpitations, arrhythmia, nce ntshav siab

- kev tsaug zog, pw tsis tsaug zog, ntxhov siab, ntxhov siab, ntxhov siab, qis zuj zus, tsis tuaj yeem mloog thiab qeeb qeeb, tsis pom kev, tsis pom kev

- kev nyuaj siab ntxhov plawv, tshee hnyo, paresis, kev ntxhov siab tsis meej pem, xav tsis thoob,

poob ntawm kev tswj tus kheej, delirium, convulsions

- ua pa nyuaj, bradycardia, tsis nco qab, tsis nco qab lawm

- xeev siab, ntuav, mob plab, cem quav, zawv plab (mob heev los nrog noj mov)

- Kev ua haujlwm ntawm lub siab ua haujlwm tsis zoo (mob siab, mob cholestatic daj ntseg - yuav tsum tsis siv tshuaj, ntxiv kev ua haujlwm ntawm "mob siab" transaminases, alkaline phosphatase)

- kev txwv tsis pub mob pob txha hematopoiesis (mob ntshav qab zib, thrombocytopenia, leukopenia, granulocytopenia)

- kev fab tshuaj: ua pob khaus ntawm daim tawv nqaij, tso zis, pob khaus tawv nqaij (suav nrog maculopapular thiab bullous), erythema

- cov kev mob tshwm sim ntawm sulfonylurea derivatives: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, kev tsis haum vasculitis, ua rau lub siab ua rau lub siab tsis ua haujlwm.

Cov tshuaj sib cuam tshuam

Txhim kho cov txiaj ntsig ntawm anticoagulants (warfarin); kev kho tshuaj ntau dua ntawm cov tshuaj anticoagulant yuav tsum tau ua.

Miconazole (nrog kev tswj hwm kev tswj hwm thiab thaum siv lub ntsej muag rau ntawm lub qhov ncauj mucosa) txhim kho qhov kev tiv thaiv hypoglycemic ntawm cov tshuaj (hypoglycemia yuav dhau mus txog thaum tsis nco qab).

Phenylbutazone (kev tswj hwm kev tswj hwm) txhim kho cov nyhuv hypoglycemic ntawm cov tshuaj (hloov chaw vim plasma protein thiab / lossis qis tawm ntawm lub cev), ntshav qabzib tswj thiab tshuaj kho glyclazide yog tsim nyog, ob qho tib si thaum phenylbutazone tswj hwm thiab tom qab rho tawm.

Ethanol thiab ethanol-muaj cov tshuaj txhim kho kev txo qis, tiv thaiv kev tiv thaiv tsis tuaj yeem, tuaj yeem pab txhawb kev txhim kho hypoglycemic coma.

Nrog rau kev tswj hwm tib lub sijhawm nrog rau lwm cov tshuaj hypoglycemic (insulin, acarbose, biguanides), beta-blockers, fluconazole, angiotensin hloov mus rau enzyme inhibitors (ACE) (captopril, enalapril), H2-histamine receptor blockers (cytoxidamides, cytaminidamines) thiab cov tshuaj tsis-steroidal los tiv thaiv cov tshuaj tiv thaiv - muaj cov nyhuv ntshav qabzib ntau dua thiab muaj kev pheej hmoo ntawm hypoglycemia.

Danazole ua rau muaj kev cuam tshuam rau ntshav qab zib. Thaum ua ke nrog gliclazide, nws yog ib qho tsim nyog los tswj cov ntshav qabzib thiab kho cov koob tshuaj gliclazide, ob qho tib si thaum tswj hwm ntawm danazol thiab tom qab nws tshem tawm.

Chlorpromazine hauv kev txhaj tshuaj ntau dua (ntau dua 100 mg / hnub) nce cov piam thaj hauv cov ntshav, txo cov ntshav hauv insulin. Nws yog qhov tsim nyog los tswj cov ntshav qabzib thiab kho cov koob tshuaj ntawm gliclazide, ob qho tib si thaum tswj hwm ntawm chlorpromazine thiab tom qab nws tshem tawm.

Glucocorticosteroids (muaj kab ke, mob plab rau sab nrauv, sab nraud, lub chaw tso ntshav tawm) nce cov ntshav qabzib nrog txoj kev txhim kho ntawm ketoacidosis (txo qis hauv kev ua kom tsis haum carbohydrate). Nws yog qhov tsim nyog los tswj cov ntshav qabzib thiab kho cov koob tshuaj ntawm gliclazide, ob qho tib si thaum tswj hwm glucocorticosteroids thiab tom qab lawv tshem tawm.

Ritodrin, salbutamol, terbutaline (iv) - ua kom ntshav qabzib ntxiv. Kev tswj ntshav qabzib tau pom zoo thiab, yog tias tsim nyog, hloov pauv ntawm tus neeg mob mus rau kev kho mob insulin.

Cov lus qhia tshwj xeeb

Thaum noj cov tshuaj no, kev txiav txim siab tsis tu ncua ntawm cov ntshav ceev cov ntshav thiab glycosylated hemoglobin yog qhov tsim nyog.

Kev phais mob thiab kev raug mob loj, kev kub nyhiab, kab mob kis nrog febrile syndrome yuav tsum tsis siv tshuaj txuas ntxiv hauv qhov ncauj thiab ua cov tshuaj insulin.

Cov neeg mob yuav tsum tau ceeb toom txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib siab ntau thaum muaj kev noj tshuaj ethanol uas muaj tshuaj (nrog rau kev txhim kho disulfiram-zoo li cov tshuaj tiv thaiv: mob plab, xeev siab, ntuav, mob taub hau), tsis siv tshuaj tiv thaiv kab mob, thiab kev tshaib plab.

Ib qho kev hloov kho koob tshuaj yog qhov tsim nyog rau kev tawm dag zog lub cev thiab lub siab, hloov kev noj zaub mov.

Raws li txoj cai, cov tsos mob ntawm hypoglycemia ploj tom qab noj mov uas muaj nplua nuj hauv carbohydrates (piv txwv li, qab zib), noj cov khoom qab zib tsis pab txo cov tsos mob hypoglycemic. Kev muaj ntshav qab zib yuav rov huam mob dua txawm tias pib pab tau zoo. Yog tias cov tsos mob hypoglycemic muaj mob hnyav lossis lub sijhawm ntev, txawm tias muaj kev txhim kho ib ntus tom qab noj zaub mov nplua nuj hauv carbohydrates, kev kho mob xwm txheej ceev yog tsim nyog, mus txog tsev kho mob.

Tshwj xeeb tshaj yog rhiab rau qhov kev txiav txim ntawm cov tshuaj hypoglycemic yog cov neeg laus, cov neeg mob uas tsis tau txais kev noj haus zoo, nrog rau lub xeev tsis muaj zog txaus, cov neeg mob kev txom nyem los ntawm pituitary-adrenal tsis txaus. Cov chaw txhaj tshuaj tiv thaiv kev mob ntshav qab zib siab tuaj yeem ua npog ntsej muag thaum noj beta-blockers, clonidine, reserpine, guanethidine. Kev txhim kho ntawm cov tshuaj tiv thaiv theem nrab yog qhov ua tau (nws yuav tsum tau qhov txawv ntawm thawj qhov, uas qhov tshuaj tsis muab qhov kev cia siab tshwm sim ntawm kev kho mob thaum thawj zaug).

Kev noj tshuaj sulfonylurea rau cov neeg mob uas muaj ntshav qabzib-6-phosphate dehydrogenase tsis muaj peev xwm (G6PD) tuaj yeem ua rau hemolytic tsis txaus. Ceev faj yuav tsum tau siv thaum sau tshuaj Glidiab rau cov neeg mob G6PD tsis muaj peev xwm thiab xav txog lwm txoj kev kho mob nrog lwm cov tshuaj.

Cov tshuaj muaj pes tsawg leeg suav nrog lactose monohydrate, hauv kev sib txuas nrog qhov no, Glidiab yuav tsum tsis txhob siv rau hauv cov neeg mob uas muaj mob galactosemia, glucose-galactose malabsorption, thiab lactase deficiency.

Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav lub tsheb lossis cov phom sij phom sij

Thaum lub sijhawm kho mob, yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm yam kev phom sij uas yuav tsum muaj kev mloog zoo thiab ceev ntawm cov kev tiv thaiv psychomotor.

Noj ntau dhau

Cov tsos mob: hypoglycemia, tsis hnov ​​qab nco qab, ntshav qab zib tsis xeev plab.

Kev Kho Mob: yog hais tias tus neeg mob nco qab, haus dej qab zib, thaum tsis nco qab lawm, kev tswj hwm kev tswj hwm 40% dextrose, tom qab ntawd iv 5% dextrose kua txia kom txog thaum cov ntshav qabzib concentration nce mus txog 5.55 mol / l, 1-2 mg glucagon v / m, tswj xyuas qhov kev mloog zoo ntawm cov piam thaj hauv cov ntshav txhua 15 feeb, nrog rau kev txiav txim siab pH, urea, creatinine thiab electrolytes hauv cov ntshav. Tom qab nws rov qab nco qab, nws yog ib qho tsim nyog yuav tsum muab cov neeg mob cov zaub mov nplua nuj nyob hauv cov khoom noj zom zaub mov kom yooj yim (kom tsis txhob rov qab txhim kho hypoglycemia). Nrog cerebral edema, mannitol thiab dexamethasone. Kev lim ntshav yog qhov ua tsis zoo.

Chaw tsim tshuaj paus

AKRIKHIN OJSC, Lavxias Federation,

142450, cheeb tsam Moscow, Noginsky koog tsev kawm ntawv, lub nroog ntawm Staraya Kupavna,

Xovtooj / Fax: (495) 702-95-03.

Lub npe thiab lub teb chaws ntawm daim ntawv pov thawj rau npe tuav

AKRIKHIN OJSC, Lavxias Federation,

Chaw nyob ntawm lub koom haum lees txais kev tsis txaus siab los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo (cov khoom lag luam) hauv thaj chaw ntawm cov koom pheej ntawm Kazakhstan:

AKRIKHIN OJSC, Lavxias Federation,

142450, cheeb tsam Moscow, Noginsky koog tsev kawm ntawv, lub nroog ntawm Staraya Kupavna,

Li cas Glidiab MV

Yuav tsum tswj cov glycemic nruj kom tsis txhob muaj teeb meem rau cov ntshav qab zib lig. Raws li txoj cai, txoj kev kho mob suav nrog kev kho kev noj zaub mov thiab kev ua si. Nrog rau hom kab mob 2, cov kev ntsuas no feem ntau tsis txaus, yog li cov lus nug tshwm sim ntawm kev teem caij cov tshuaj txo cov ntshav qab zib. Cov theem pib ntawm tus kab mob yog tus cwj pwm los ntawm insulin tsis kam thiab nce siab ntxiv cov piam thaj hauv daim siab, yog li lub sijhawm no cov tshuaj zoo tshaj plaws yog metformin (piv txwv, Glucofage).

Chronic hyperglycemia hauv lub sijhawm luv luv ua rau cov kabmob ua rau pancreatic cell ua haujlwm tsis zoo thiab ua tsis tiav cov tshuaj insulin. Thaum cov kev hloov zoo li no pib, nws raug nquahu kom ntxiv cov ntsiav tshuaj rau kev kho mob yav dhau los uas tuaj yeem txhawb qhov tsim tawm ntawm insulin. Ntawm cov tshuaj muaj tam sim no, DPP4 inhibitors, muaj zog zuj zus, thiab sulfonylureas muaj peev xwm ntawm qhov no.

Thawj ob pawg tau siv qhov tsis ntev los no, txawm hais tias cov tshuaj muaj txiaj ntsig, tab sis kim heev. Hauv ntau thaj tsam ntawm Russia, tau txais lawv dawb yog qhov teeb meem. Tab sis qhov pheej yig tsis tuaj yeem ntawm sulfonylureas tau lees tias yuav tsum tau sau tseg nyob hauv txhua lub tsev kho mob. Qhov kev nyab xeeb thiab niaj hnub no ntawm cov tshuaj no yog glimepiride (Amaryl) thiab hloov kho hom glyclazide (Diabeton MV thiab nws cov duab analogues, suav nrog Glidiab MV)

Diabeton yog ib hom tshuaj qub, Glidiab yog lub tsev tsim tawm ntawm cov khoom lag luam zoo. Cov kev tshawb fawb tau lees paub qhov cuam tshuam zoo tib yam ntawm cov tshuaj no ntawm glycemia.

Cov lus qhia rau kev siv piav qhia txog ob peb yam tseem ceeb ntawm Glidiab:

1. Rov qab los ntawm cov theem 1 ntawm kev tsim cov tshuaj insulin, vim tias cov piam thaj ntawd pib tawm lub nkoj tam sim ntawd tom qab tau txais.
2. Ua Amplification 2 theem.
3. Txo cov platelet adhesion, txhim kho kev muaj peev xwm ntawm vascular epithelium kom yaj thrombi. Cov nyhuv no txo ​​txoj kev pheej hmoo ntawm kev mob vascular.
4. Qhov nruab nrab ntawm cov dawb radicals, cov lej muaj ntau ntxiv nrog ntshav qab zib.

Muaj cov kev tshawb fawb ua pov thawj tias sulfonylurea kev npaj ua kom muaj kev puas tsuaj ntawm beta hlwb, ua rau cov insulin tsis muaj zog thiab yuam kom cov neeg mob ntshav qab zib hloov mus rau kev kho mob insulin. Glidiab hauv nws pawg yog qhov zoo tshaj plaws tshuaj nyob rau hauv no hais txog. Qhov nruab nrab koob ntawm cov tshuaj tsub kom nce tshuaj synthesis los ntawm 30%, tom qab ntawd nws cov khoom tsim tawm nqis 5% txhua xyoo. Nyob rau hauv lub ntuj chav kawm ntawm tus kab mob, insulin tsis muaj peev xwm nce txhua xyoo los ntawm 4%. Ntawd yog, nws tsis tuaj yeem hu rau Glidiab kom muaj kev nyab xeeb rau tus txiav, tab sis nws tseem tsis tuaj yeem sib npaug nrog cov tshuaj hnyav dua los ntawm tib pab pawg, piv txwv li, Maninil.

Kev qhia rau kev teem caij mus siv tshuaj

Raws li cov lus qhia, Glidiab tsuas yog kho rau cov neeg mob ntshav qab zib nrog 2 hom mob carbohydrate ntshaus siab. Cov nyhuv ntawm cov tshuaj yog qhia ncaj qha rau beta hlwb, uas yog qhaj ntawv ntawm ntshav qab zib hom 1. Txoj kev kho yuav tsum yog sib xyaw nrog kev noj haus thiab kev tawm dag zog, nrog kev rog rog thiab / lossis insulin tsis kam, metformin ntxiv.

Glidiab yog tsuas yog ntxiv rau metformin thiab tsuas yog thaum tus neeg mob ua tiav tag nrho cov tshuaj, tab sis tsis tuaj yeem ncav cuag lub hom phiaj glycemia. Raws li txoj cai, qhov no qhia tau qee qhov ploj ntawm pancreatic muaj nuj nqi. Txhawm rau kom muaj cov insulin tsis txaus thiab xav tau Glidiab, nws raug nquahu kom kuaj C-peptide.

Thaum pib ua mob, cov tshuaj tau raug cai tsuas yog tias cov piam thaj hauv ntshav muaj ntau heev, thiab muaj kev ua xyem xyav tias ntshav qab zib tau kuaj tau ntau xyoo tom qab nws tau pib.

Tsuas tshuaj thiab muab ntau npaum

Lub chaw tsim khoom tsim cov Glidiab hauv ob daim ntawv:

1. Glidiab ntau npaum ntawm 80 mg. Cov no yog cov ntsiav tshuaj ib txwm nrog gliclazide, cov tshuaj nquag los ntawm lawv tau nrawm rau hauv cov ntshav thiab nce mus txog qhov siab kawg tom qab 4 teev. Nws yog lub sijhawm no uas muaj kev pheej hmoo siab tshaj plaws ntawm kev mob ntshav qab zib. Qhov koob tshuaj saum toj 160 mg tau muab faib ua 2 koob tshuaj, yog li cov piam thaj tuaj yeem poob dua thaum nruab hnub.
2. Glidiab MV yog cov niaj hnub ntau dua, cov ntsiav tshuaj tau ua nyob rau hauv xws li txoj kev uas gliclazide los ntawm lawv nkag rau cov ntshav maj mam thiab tusyees. Qhov no yog qhov thiaj li hloov kho, lossis ncua ntev, tso tawm. Ua tsaug rau nws, cov txiaj ntsig ntawm Glidiab nce mus zoo thiab ntev ntev yog khaws cia nyob rau tib theem, uas ua rau kom cov tshuaj muaj txiaj ntsig, txo qhov tsim nyog koob tshuaj, thiab zam kev ua kom tsis txhob mob ntshav qab zib.

Qhov sib txawv ntawm tus nqi ntawm cov tshuaj no yog qhov me me - Glidiab MV muaj ntau dua los ntawm kwv yees li 20 rubles, thiab qhov sib txawv ntawm kev nyab xeeb yog qhov tseem ceeb, yog li ntawd, cov kws tsim khoom lag luam pom zoo tias cov neeg mob ntshav qab zib hloov mus rau qhov tshuaj tshiab. Raws li nws cov hauj lwm zoo, 1 ntsiav tshuaj ntawm Glidiab 80 yog sib npaug rau 1 ntsiav tshuaj ntawm Glidiab MV 30.

Koob tshuaj pom zoo:

Txoj cai ntawm kev nce ntau npaum li cas raws li cov lus qhia rau kev siv: yog tias pib lub koob tshuaj tsis txaus, nws tuaj yeem nce ntxiv ntawm 30 mg (80 rau niaj hnub Glidiab) tom qab ib lub hlis ntawm kev coj. Koj muaj peev xwm nce qib ntxiv ua ntej rau cov neeg mob ntshav qab zib nyob rau hauv uas cov ntshav qab zib tsis tau pauv xwb. Kev nce ntxiv sai sai yog txaus ntshai nrog hypoglycemic coma.

Yuav siv li cas Glidiab

Glidiab

Glidiab MV

Raws li cov kws kho mob, cov neeg mob uas muaj kab mob mus ntev tsis haus tag nrho cov tshuaj kho mob. Nrog rau cov ntshav qab zib hom 2, kev tsis sib haum xeeb tsis txwv rau cov ntshav siab, yog li cov neeg mob tau yuam kom noj cov tshuaj statins, tshuaj aspirin, thiab ntshav siab ntxiv rau cov tshuaj muaj ntshav qab zib. Cov ntau cov ntsiav tshuaj tau sau kho mob thiab cov tshuaj nyuab dua kev tswj hwm qhov qis, qhov qis dua qhov uas lawv yuav haus cawv thaum muaj kev qhuab qhia. Glidiab MV noj ib hnub ib zaug, tsis hais txog ntawm cov tshuaj muab tshuaj, yog li ntawd, nws yog qhov muaj feem yuav tsawg tsawg koob.

Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm lub koom haum ntawm Diabetology - Tatyana Yakovleva

Kuv tau kawm mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.

Kuv maj nrawm los qhia txoj xov zoo - Endocrinological qhov chaw tshawb fawb ntawm Lavxias Academy ntawm Medical Science tau tswj hwm los tsim cov tshuaj uas kho cov ntshav qab zib kom meej. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.

Lwm qhov xov xwm zoo: Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau txais kev nyab xeeb qhov kev saws me nyuam ntawm cov haujlwm tshwj xeeb uas them rau cov nqi tshuaj ntau. Hauv Lavxias, neeg mob ntshav qab zib kom txog thaum lub Tsib Hlis 18 (suav nrog) tuaj yeem tau txais nws - Tsuas yog 147 rubles!

Cov Mob Rov Qab Los Yuav Ua Li Cas?

Daim ntawv teev cov kev xav tsis zoo uas muaj peev xwm ua tau thaum noj Glidiab MV 30 mg thiab nws cov analogues:

1. Kev muaj ntshav qab zib tsawg tshwm sim nrog kev siv tshuaj ntau dhau, hla zaub mov lossis tsis muaj cov carbohydrates hauv nws. Nquag cov piam thaj hauv qab zib xav tau kev txhim kho kev noj haus thiab kev txo qis ntawm koob tshuaj Glidiab.
2. Kev mob plab zom mov. Txhawm kom txo txoj kev pheej hmoo ntawm qhov tshwm sim no, cov kev qhia pom zoo kom noj Glidiab tib lub sijhawm ua zaub mov.
3. Cov tawv nqaij ua xua. Raws li kev txheeb xyuas, kev tsis haum tshuaj loj dua rau kev coj ua tsis tshwm sim.
4. Hloov pauv hauv cov ntsiab lus ntawm cov feem hauv ntshav. Feem ntau nws yog qhov thim rov qab, uas yog, nws ploj nws tus kheej tom qab kev txiav ntawm kev txais neeg kawm.

Kev pheej hmoo ntawm cov ntshav qog ntshav tau kwv yees kwv yees li 5%, uas nws nqis qis dua nrog sulfonylureas qub. Cov neeg mob ntshav qab zib mellitus ua ke nrog cov kab mob hnyav ntawm lub plawv thiab cov kab mob endocrine, nrog rau kev noj cov tshuaj hormones ntev ntev, muaj ntau dua rau cov piam thaj poob. Rau lawv, qhov siab tshaj plaws uas tau tso cai ntawm Glidiab yog txwv rau 30 mg. Cov neeg mob ntshav qab zib nrog neuropathy, cov neeg laus, cov neeg mob uas feem ntau lossis ntev me ntsis ua rau lub cev ntuag ntshav qab zib, tsis hnov ​​mob cov ntshav qab zib tsawg, yog li noj Glidiab tuaj yeem muaj kev phom sij rau lawv. Hauv qhov no, cov ntsiav tshuaj ntshav qab zib uas tsis muaj qhov tshwm sim li no raug pom zoo.

Cov tshuaj tiv thaiv nrov

Ntawm cov tshuaj tiv thaiv kab mob rau kev kho mob ntawm hom 2, nws yog glyclazide npaj uas tau faib ntau tshaj plaws. Tsuas yog Metformin tuaj yeem sib tw nrog lawv hauv cov lej ntawm lub npe lag luam. Feem ntau Glidiab analogues tau ua nyob rau hauv Russia, lawv tus nqi hauv cov khw muag khoom txawv ntawm 120-150 rubles, feem ntau kim tshaj plaws Fabkis Diabeton tus nqi feem ntau yog li 350 rubles.

Glidiab cov lus piv txwv thiab hloov:

Glidiab lossis Gliclazide - uas zoo dua?

Qhov zoo ntawm cov tshuaj yog txiav txim siab los ntawm cov degree ntawm kev ua kom huv thiab qhov tseeb ntawm cov tshuaj ntawm cov tshuaj nquag, kev nyab xeeb ntawm cov khoom siv pabcuam. Glidiab thiab Glyclazide (ntau lawm ntawm Ozone) yog qhov zoo ib yam rau cov tsis muaj no. Ob lub Akrikhin thiab Ozone muaj cov cuab yeej siv niaj hnub no, ob lub tuam txhab tsis tsim cov tshuaj yeeb tshuaj lawv tus kheej, tab sis yuav nws, ntxiv rau, los ntawm tib lub tuam txhab Suav. Thiab txawm hais tias nyob rau hauv cov muaj pes tsawg leeg ntawm excipients, Glidiab thiab Gliclazide yuav luag rov ua ib leeg. Kev tshuaj xyuas cov neeg uas tau noj cov tshuaj no ntau tshaj ib xyoos kuj qhia meej lawv txoj hauv kev muaj txiaj ntsig zoo ntshav qab zib.

Glyclazide muaj 2 qhov kev xaiv - 30/60 mg, Glidiab - tsuas yog 30 mg, Glidiab tuaj yeem hloov kho thiab kev tso tawm ib txwm, Gliclazide tsim tawm tsuas yog ncua - uas yog txhua qhov sib txawv ntawm cov ntsiav tshuaj no.

Tus txheej txheem ntawm kev nqis tes ua thiab kev taw qhia rau kev siv

Glidiab MV yog ib tus neeg sawv cev hypoglycemic rau cov pab pawg ntawm sulfonylurea derivatives ntawm lub cim thib 2. Cov tshuaj yog muaj gliclazide thiab tshem tawm. Glyclazide hauv ib ntsiav tshuaj muaj 80 mg lossis 30 mg.

Cov tshuaj tiv thaiv tsis ua hauj lwm li cas? Glyclazide raws li qhov nqus tau stimulates cov leeg glycogen synthetase kev ua ub no thiab cov kua dej tso pa tawm. Tsis tas li, cov tshuaj no potentiates insulin secretory nyhuv ntawm cov piam thaj, thiab ua rau muaj kev nce siab hauv qhov rhiab ntawm cov ntaub so ntswg mus rau insulin.

Ntxiv mus, gliclazide pab txo cov kis ntawm kev noj zaub mov thiab qhov pib ntawm lub cev sib xyaw cov kua dej ntawm insulin. Yog tias koj saib cov lus qhia rau kev siv rau Glidiab, koj tuaj yeem pom tias thaum koj siv cov ntsiav tshuaj, lub siab ntawm hyperglycemia poob qis, thiab thaum ntxov ntawm cov tshuaj insulin tso rov qab.

Tag nrho cov yam cuam tshuam ncaj qha cuam tshuam rau cov metabolism hauv carbohydrate thiab microcirculation. Yog tias koj ntseeg tias cov lus qhia, tom qab ntawd Glidiab MV pab txo qis rau kev txhawm thiab txhawm rau platelets, thiab tib lub sijhawm ua rau vascular permeability. Yooj yim muab, nrog kev siv cov ntsiav tshuaj, qhov ntxim nyiam ntawm kev muaj mob ntawm microthrombosis thiab atherosclerosis yog txo qis.

Cov kev tshawb fawb kuj tau pom tias tus neeg sawv cev hypoglycemic pab ua kom qeeb ntawm kev txhim kho ntawm cov teeb meem xws li mob ntshav qab zib ntawm lub cev tsis nyob ntawm theem. Ntxiv mus, siv Glidiab MV ntsiav tshuaj tuaj yeem cuam tshuam rau kev ua haujlwm ntawm kev noj zaub mov noj rau cov neeg mob nyhav dhau.

Kuv xav nco ntsoov tias cov tshuaj metabolites ntawm cov tshuaj tau nthuav tawm ua ke nrog cov zis hauv ib daim ntawv hloov pauv, thiab ua ke nrog quav hauv daim ntawv ntawm metabolites.

Cov lus qhia rau kev siv tshuaj

Nyob rau hauv rooj plaub dab tsi yog nws raug nquahu kom siv Glidiab 80 ntsiav tshuaj? Cov lus qhia tau hais tias nws raug nquahu kom siv cov tshuaj hauv kev kho mob hom 2 ntshav qab zib mellitus, yog tias kev noj zaub mov noj thiab kev tawm dag zog tsis pab tswj cov ntshav qabzib.

Ua nrog rau lwm cov tshuaj, Glidiab MB tsis tshua muaj neeg siv. Tab sis nws yuav tsum raug sau tseg tias qhov ua kom qis ntawm cov tshuaj tiv thaiv kab mob tuaj yeem nce ntxiv yog tias, nrog rau kev siv tshuaj kho mob, noj thiab ua si kis las yog qhov sib npaug.

Yuav noj li cas? Qhov hno koob yog 80 mg. Ntxiv mus, qhov ntau zaus ntawm kev siv yog 2 zaug hauv ib hnub - thaum sawv ntxov thiab yav tsaus ntuj. Nws raug nquahu kom noj cov ntsiav tshuaj 30-60 feeb ua ntej noj mov.

Yog tias qhov koob tshuaj tsawg kawg nkaus ntawm 80 mg tsis muaj ib qho kev tiv thaiv hypoglycemic, ces qhov muab tshuaj yog maj mam nce. Feem ntau, hauv hom 2 mob ntshav qab zib, koob ntawm 160 mg yog qhov zoo tshaj. Qhov siab tshaj plaws tau ntau npaum li cas ntawm cov tshuaj yog 320 mg.

Tab sis peb yuav tsum nco ntsoov tias nrog rau cov koob tshuaj ntau ntxiv, qhov ntxim nyiam ntawm kev muaj ntshav qab zib thiab lwm yam mob hnyav nce ntxiv.

Kev sib cuam tshuam txog yeeb tshuaj thiab Tshuaj Tiv Thaiv

Nws yuav tsum nco ntsoov tias muaj ntau cov tshuaj muaj peev xwm nce cov nyhuv hypoglycemic ntawm yeeb tshuaj Glidiab MB. Yog li, cov lus qhia tau sau tseg tias cov tshuaj yuav tsum yog ua tib zoo ua ke nrog histamine H2-receptor blockers, tshuaj tsis-steroidal anti-inflammatory tshuaj, antifungal agents, ACE inhibitors.

Cov tshuaj tiv thaiv tuberculosis, beta-adrenoblockers, nphav phav phav hom anticoagulants, anabolic steroids, MAO inhibitors, salicylates thiab lwm tus kuj tseem tuaj yeem ua rau muaj kev tiv thaiv hypoglycemic.

Yog vim li cas, ua ntej siv cov ntsiav tshuaj Glidiab, koj yuav tsum ua tib zoo kawm cov lus qhia thiab sab laj tus kws kho mob.

Ntawm cov contraindications kom siv cov ntsiav tshuaj yuav qhia tau:

1. Ntshav Qab Zib Hom 1 yog insulin-vam khom.
2. Ntshav qab zib ketoacidosis.
3. Xav sim lossis tsis nco qab. Ntxiv mus, ib qho nruj contraindication yog hyperosmolar coma.
4. Leukopenia
5. Lub sijhawm cev xeeb tub.
6. Lub sijhawm lactation.
7. Mob rau hepatic thiab lub raum tsis ua haujlwm.
8. Cov xwm txheej uas nrog ua ke los ntawm kev ua txhaum ntawm cov txheej txheem ntawm kev nqus ntawm cov khoom noj, thiab kev txhim kho ntawm lub qog ntshav qab zib. Cov mob no suav nrog kev cuam tshuam ntawm cov hnyuv, paresis ntawm lub plab thiab cov kab mob kis.
9. Ua xua rau cov khoom xyaw ntawm cov ntsiav tshuaj.
10. Tej yam mob uas yuav tsum tau siv tshuaj insulin. Cov mob no suav nrog hlawv, raug mob, lossis phais mob.
11. Kev quav cawv
12. Lub siab ntsws Febrile.

Tsis tas li, cov tshuaj yuav tsum tau siv nrog ceev faj hauv cov neeg kev txom nyem los ntawm cov thyroid tsis ua hauj lwm.

Kev txheeb xyuas thiab cov kev mob tshwm sim ntawm Glidiab

Qhov kev ntsuam xyuas txog Glidiab yog dab tsi? Tus mob ntshav qab zib tau teb zoo rau cov tshuaj. Coob tus neeg tau txais kev txaus siab los ntawm tus nqi pheej yig ntawm cov tshuaj, thiab tus nqi tsim nyog siab.

Ntxiv mus, Gladiab, raws li cov neeg mob ntshav qab zib, yog qhov zoo vim tias nws tsis tshua muaj kev phiv los ntawm kev siv tshuaj tsawg. Lwm qhov kev ntaus nqi ntawm cov tshuaj rau cov tib neeg yog qhov tseeb tias nws nce lub txiaj ntsig ntawm kev kho kev noj haus.

Cov kev phiv dab tsi tuaj yeem ua rau cov tshuaj hypoglycemic ua rau? Raws li cov lus qhia, cov tshuaj tuaj yeem ua rau:

• Kev ua txhaum ntawm endocrine system. Lawv qhia raws li kev mob ntshav qab zib. Tab sis nws yuav tsum raug sau tseg tias qhov kev lees paub no tsuas yog tshwm sim nrog kev xaiv tsis zoo ntawm qhov tshuaj.
• Kev tsis haum xeeb, nkees nkees, tawm tsam kev tawm tsam, tshee ntawm nqaj, mob taub hau, kiv taub hau, nce zog.
• Tsis pom qhov pom tseeb tseeb.
• Cov Niampaus.
• Lub Neej Bradycardia
• Ua pa.
• Ncuav Qab Zib.
• Thrombocytopenia, ua haujlwm tsis txaus, leukopenia.
• Kev ua xua tsis haum.
• Digestive system malfunction. Tus neeg yuav mob raws plab, zoo li qhov hnyav nyob hauv thaj av epigastric, xeev siab, tsis nco qab, cholestatic jaundice, kev ua si ntawm hepatic transaminases ntau dua.

Feem ntau, cov kev mob tshwm sim los daws lawv tus kheej tom qab tsis haus yeeb tshuaj thiab tau txais kev kho mob raws li qhov tsim nyog.

Qhov zoo tshaj plaws analogue ntawm Glidiab

Cov analogues ntawm Glidiab yog dab tsi? Hloov chaw, ntau hom kab mob hypoglycemic raws li metformin hydrochloride tuaj yeem siv. Ib pawg ua tau zoo heev ntawm analog yog Formine. Cov tshuaj no yog Glidiab's hloov zoo tshaj plaws.

Tus nqi ntawm cov tshuaj yog kwv yees li 180-260 rubles. Cov tshuaj muaj nyob rau hauv qhov ntau npaum ntawm 500 mg, 850 mg thiab 1 gram. Ib pob muaj 60 ntsiav tshuaj. Cov tshuaj muaj pes tsawg leeg suav nrog metformin hydrochloride, povidone, primellose, magnesium stearate.

Qhov nquag ua haujlwm ntawm formin ua li cas? Cov lus qhia tau qhia tias metformin hydrochloride inhibits cov txheej txheem ntawm gluconeogenesis nyob rau hauv daim siab, thiab pab txo qis kev nqus ntawm cov piam thaj los ntawm cov hnyuv.

Tsis tas li, cov nquag tiv thaiv txhim kho kev siv hluav taws xob ntau ntawm cov piam thaj, thiab pab txhawm rau txhim kho qhov rhiab ntawm cov ntaub so ntswg mus rau qhov cuam tshuam ntawm insulin. Hauv qhov no, metformin hydrochloride tsis cuam tshuam rau cov txheej txheem ntawm insulin secretion los ntawm beta hlwb, vim tias qhov ntxim nyiam ntawm kev txhim kho hypoglycemia txo qis.

Nrog kev pab los ntawm Formethin, ntshav qab zib hom 2 tuaj yeem kho tau. Tshwj xeeb feem ntau, cov tshuaj yog siv thaum tus mob ntshav qab zib ua mob rog thiab nyob rau hauv qhov twg kev noj zaub mov tsis pab ua kom cov ntshav piam thaj tseem ceeb. Kuv xav nco ntsoov tias cov tshuaj feem ntau siv ua ke nrog cov tshuaj cuam tshuam nrog sulfonylurea derivatives.

Yuav noj li cas? Thawj koob tshuaj yog 1000-1700 mg ib hnub twg. Ntxiv mus, kev muab tshuaj tau muab faib ua 2 koob. Nws yog qhov zoo dua rau kev siv tshuaj tom qab noj mov, haus dej ntau.

Yog hais tias cov piam thaj hauv ntshav tsis nyob ruaj khov, tom qab ntawd cov tshuaj yog maj mam nce mus rau 2-3 grams hauv ib hnub. Qhov siab tshaj uas tau tso cai niaj hnub rau Formetin yog 3 grams, tsis ntau dua. Tab sis cov neeg mob laus yog pom zoo kom noj tsis tshaj 1 gram nyob rau ib hnub.

Cov kev txwv tsis pub siv rau qhov tshuaj:

1. Kev fab tshuaj rau cov Cheebtsam.
2. Lub raum khiav tsis zoo, hauv lub raum tsis ua haujlwm.
3. Cov theem mob myocardial infarction.
4. Lub cev qhuav dej.
5. Plawv lossis ua pa tsis ua haujlwm.
6. Cerebrovascular kev huam yuaj.
7. Kev haus cawv mus ntev
8. Cev xeeb tub thiab lactation.
9. Cov mob uas muaj qhov xav tau ntawm kev siv tshuaj insulin. Nws tuaj yeem yog cov kev raug mob hnyav, hlawv lossis phais mob.
10. Cov kab mob lactic acidosis.
11. Ua raws li kev noj zaub mov nruj, uas muab kev txo qis rau cov calories txhua hnub rau 1000 kilocalories.
12. Daim ntawv thov lub sijhawm 2 hnub dhau los ntawm kev tshawb nrhiav xoo hluav taws xob nrog kev qhia ntawm kev sib piv ntawm iodine muaj cov tshuaj muaj yees. Los ntawm txoj kev, cov tshuaj yuav tsum tsis txhob noj 2 hnub ua ntej xws li kev xoo hluav taws xob.

Ntawm cov kev mob tshwm sim ntawm cov tshuaj, muaj kev tsis sib haum xeeb hauv kev ua haujlwm ntawm lub plab zom mov, kev mob plab zom mov, ua rau lub cev tsis muaj ntshav, tsis muaj ntshav qab zib thiab kev fab tshuaj tsis haum. Daim vis dis aus hauv tsab xov xwm no yuav qhia koj tias tshuaj dab tsi muaj ntshav qab zib.