Glimecomb kuaj xyuas ntshav qab zib

Tau ntau xyoo tsis muaj kev vam meej nrog DIABETES?

Lub taub hau ntawm lub koom haum: “Koj yuav xav tsis thoob tias yoojyim kho mob ntshav qab zib li cas los ntawm kev noj tshuaj txhua hnub.

Kev mob ntshav siab, cov yam ntxwv tseem ceeb ntawm cov uas suav tias yog kev rog dhau, hom 2 mob ntshav qab zib mellitus thiab kub siab yog qhov teeb meem ntawm cov haiv neeg niaj hnub no. Muaj ntau zuj zus ntawm cov neeg hauv cov xeev dej siab tau nyob nrog tus mob no.

Glucophage rau hom 2 mob ntshav qab zib
Cov lus sib xyaw thiab daim ntawv ntawm cov tshuaj
Glucophage Ntev rau ntshav qab zib
Mechanism ntawm kev ua
Leej twg yuav tsum tsis txhob noj cov tshuaj no?
Glucophage thiab menyuam yaus
Sab Cuam Tshuam Cov Kab Mob Hlab
Dab tsi ntxiv lwm yam tshuaj cuam tshuam rau cov nyhuv ntawm glucophage?
Cov Lus Nquag Nug
Siofor lossis Glucophage: uas zoo dua rau ntshav qab zib?
Glucophage los ntawm ntshav qab zib: tshuaj xyuas

Yuav pab koj tus kheej kom rov qab rau lub xeev ntawm lub cev nrog kev siv nyiaj tsawg tshaj plaws li cas? Qhov tseeb, feem ntau ntawm cov neeg rog yog cov neeg tsis txaus siab lossis tsis tuaj yeem ua kis las, thiab mob ntshav qab zib mellitus yog, qhov tseeb, tus kabmob sib kis. Txoj kev lag luam kws tshuaj los cawm.

Cov kev cai rau noj cov tshuaj Glimecomb thiab cov tshuaj analog

Txog kev kho mob pob qij txha, peb cov neeg nyeem tau siv DiabeNot siv tau zoo. Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

Glimecomb hais txog cov tshuaj uas siv rau ntshav qab zib hom 2.

Lub cuab yeej muaj qhov ua ke nrog hypoglycemic cov cuab yeej.

Tom qab noj cov tshuaj, qhov ib txwm ua tsis tiav ntawm cov piam thaj hauv tus neeg mob cov ntshav tau sau tseg.

Cov ntaub ntawv dav dav, muaj pes tsawg leeg thiab daim ntawv tso tawm

Cov tshuaj tshwj xeeb hais txog cov neeg sawv cev hypoglycemic coj noj ntawm qhov ncauj. Cov cuab yeej muaj kev sib koom ua ke. Ntxiv nrog rau cov nyhuv qab zib-qis, Glimecomb muaj cov nyhuv ua pancreatic. Hauv qee kis, cov tshuaj muaj cov nyhuv ntxiv.

Kev npaj muaj Metformin hydrochloride nyob rau hauv ib qho nyiaj ntawm 500 mg thiab Gliclazide - 40 mg, ntxiv rau cov neeg tsis muaj txiaj ntsig sorbitol thiab croscarmellose sodium. Txo me me, magnesium stearate thiab povidone muaj nyob hauv cov tshuaj.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj ntsiav cylindrical hauv dawb, qab zib lossis daj ntxoov. Rau cov ntsiav tshuaj, marbling yog tau. Tshuaj tua kab mob muaj qhov pheej hmoo thiab ib qho bevel.

Glimecomb raug muag hauv 10 ntsiav tshuaj hauv qhov hlwv blister. Ib pob muaj 6 pob.

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Glimecomb yog ib hom tshuaj uas ua ke nrog cov tshuaj hypoglycemic ntawm biguanide pawg thiab sulfonylurea derivatives.

Tus neeg sawv cev yog tus cwj pwm los ntawm pancreatic thiab ntxiv cov teebmeem ntxiv.

Gliclazide yog ib yam khoom tseem ceeb ntawm cov tshuaj. Nws yog sulfonylurea derivative.

nquag insulin ntau lawm
txo cov ntshav piam thaj concentration,
txo cov platelet adhesion, uas tiv thaiv kev tsim cov ntshav txhaws hauv cov hlab ntshav,
normalization ntawm vascular permeability.

Gliclazide inhibits qhov tshwm sim ntawm microthrombosis. Thaum lub caij nyoog siv cov tshuaj hauv cov neeg mob ntshav qab zib nephropathy, kev txo qis ntawm cov proteinuria (muaj cov protein nyob hauv cov zis) tau pom.

Gliclazide cuam tshuam qhov hnyav ntawm tus neeg mob noj cov tshuaj. Nrog rau cov khoom noj kom haum rau cov neeg mob ntshav qab zib noj Glimecomb, qhov hnyav yog sau tseg.

Metformin, uas yog ib feem ntawm cov tshuaj, yog hais txog cov pab pawg biguanide. Cov tshuaj yuav pab txo cov piam thaj hauv cov ntshav, pab ua kom txoj kev nqus ntawm cov piam thaj hauv plab thiab cov hnyuv. Metformin pab ceev cov txheej txheem ntawm kev siv cov kua nplaum los ntawm cov nqaij hauv lub cev.

Qhov tshuaj txo qis cov roj cholesterol, cov lipoproteins tsawg tsawg. Hauv qhov no, Metformin tsis cuam tshuam rau theem ntawm lipoproteins ntawm ntau qhov sib txawv. Zoo li Gliclazide, nws txo qhov hnyav ntawm tus neeg mob. Nws tsis muaj dab tsi tshwm sim thaum tsis muaj insulin hauv cov ntshav. Tsis pab ua rau pom ntawm hypoglycemic kev tshwm sim. Gliclazide thiab metformin sib txawv nqus thiab ua rau tus neeg mob siab. Gliclazide yog tus cwj pwm los ntawm kev nqus ntau dua li ntawm Metformin.

Qhov siab tshaj plaws ntawm Gliclazide hauv cov ntshav tau mus txog tom qab 3 teev txij li lub sijhawm ntawm kev noj tshuaj. Cov tshuaj no dhau los ntawm lub raum (70%) thiab cov hnyuv (12%). Qhov kev tshem tawm ib nrab-lub neej ncav 20 teev.

Qhov txheeb ntawm cov xyoob ntoo ntawm Metformin yog 60%. Cov tshuaj nquag txuam nrog rau cov ntshav liab. Ib nrab-lub neej yog 6 teev. Kev rho tawm hauv lub cev tshwm sim los ntawm lub raum, nrog rau txoj hnyuv (30%).

Kev taw qhia thiab contraindications

Cov tshuaj yog pom zoo rau cov neeg mob ntshav qab zib nrog hom ntshav qab zib hom 2 yog tias:

kev kho mob dhau los nrog rau kev noj haus thiab ce tsis muaj qhov ua kom zoo,
muaj qhov xav tau los hloov kev kho ua ke dhau los siv kev siv Gliclazide nrog Metformin hauv cov neeg mob uas muaj cov ntshav qabzib nyob ruaj.

Cov tshuaj yog tus cwj pwm los ntawm cov kev qhia ntau yam ntawm contraindications, uas:

muaj cov ntshav qab zib hom 1,
tus kheej intolerance mus rau lub Cheebtsam ntawm cov tshuaj,
raum tsis ua hauj lwm zoo,
cev xeeb tub
daim siab ua hauj lwm
lactic acidosis,
lub plawv tsis ua hauj lwm
mob ntshav qab zib coma
kev pub mis
ntau yam kab mob
myocardial infarction
Kab mob porphyrin
kuaj mob ntshav qab zib
kev phais yav dhau los,
lub sijhawm ntawm tus neeg mob mus kuaj xoo hluav taws xob thiab kev soj ntsuam siv cov khoom siv radioisotopes nrog kev qhia txog iodine-cov tshuaj uas tsis zoo rau hauv lub cev (nws yog txwv tsis pub noj 2 hnub ua ntej thiab tom qab cov kev tshawb fawb no),
raug mob hnyav
poob siab mob tiv thaiv keeb kwm ntawm kab mob hauv lub plawv thiab raum,
ua pa tsis ua hauj lwm
cawv intoxication,
cov piam thaj hauv ntshav tsawg (hypoglycemia),
mob raum zoo
haus cawv ntev,
nws kim heev hlawv lub cev,
mas ua raws cov neeg mob hypocaloric noj,
noj miconazole,
mob plab ketoacidosis.

Cov lus qhia rau kev siv thiab cov lus qhia tshwj xeeb

Qhov ntau thiab tsawg ntawm cov tshuaj yog ib leeg rau txhua tus neeg mob. Nws raug nquahu kom noj 1-3 ntsiav tshuaj nyob rau ib hnub. Hauv cov hnub tom qab ntawm kev kho mob, qhov nce ntxiv ntawm koob tshuaj yog ua tau, raws li qhov ntsuas ntawm cov piam thaj hauv cov ntshav ntawm tus neeg mob thiab qhov ntsuas ntawm nws qhov mob. Rau Glimecomb, kev muab tshuaj ntau tshaj plaws yog 5 ntsiav tshuaj ib hnub.

Cov tshuaj raug pom zoo kom noj thaum sawv ntxov thiab yav tsaus ntuj. Cov tshuaj yog noj thaum lub sijhawm lossis tom qab noj mov.

Cov cuab yeej tsis pom zoo rau cov neeg mob uas laus dua 60 xyoo, ua haujlwm lub cev tsis zoo. Nrog rau kev ua haujlwm nyuaj thiab noj Glimecomb hauv cov neeg laus, cov kab mob lactic acidosis yuav tshwm sim.

Cev xeeb tub yog ib qho ntawm cov contraindications kom noj cov tshuaj no. Thaum cev xeeb tub tshwm sim, ntxiv rau ua ntej nws npaj, nws yog ib qho tsim nyog los hloov cov tshuaj nrog tshuaj insulin.

Kev pub niam mis kuj yog ib qho kev tsis sib haum vim yog lub siab nqus cov tshuaj ntawm cov tshuaj mus rau niam mis. Nws yog ib qho tsim nyog yuav tsum tshem tawm qhov kev pub noj rau lub sijhawm noj Glimecomb los ntawm leej niam lossis kom tsum tsis txhob noj cov tshuaj nws tus kheej thaum lactation.

Nrog kev ceev faj, nws yog qhov yuav tsum tau noj cov tshuaj no rau cov neeg mob nrog:

npaws
cov thyroid teeb meem
adrenal tsis txaus.

Cov tshuaj no yog txwv rau cov neeg mob uas muaj kab mob hauv lub siab, nrog rau lub raum lub raum lub raum, nrog rau kev poob siab, lub cev qhuav dej, thiab lwm yam xwm txheej hnyav.

Cov tshuaj no tsuas yog noj rau cov mob uas cov neeg mob ua raws li kev noj zaub mov kom muaj calorie tsawg nrog kev noj zaub mov carbohydrates tsawg. Lub sijhawm thaum ntxov ntawm kev kho mob, yuav tsum tswj ntshav qab zib kom ntshav. Kev kho nrog cov tshuaj yog nqa tawm tsuas yog nyob rau hauv cov neeg mob uas tau txais kev noj haus tsis tu ncua.

Sulfonylureas, uas yog ib feem ntawm cov tshuaj, tuaj yeem ua rau mob ntshav qab zib. Nws tshwm sim nrog kev noj zaub mov hauv lub cev tsawg thiab ua si lub cev. Nws yog ib qho tsim nyog yuav tsum tau hloov kho qhov tshuaj tsis tu ncua, tshwj xeeb tshaj yog nyob rau cov neeg laus.

Kev mob ntshav siab ntshav qab zib tuaj yeem tshwm sim hauv cov neeg mob thaum noj:

ethyl haus cawv
non-steroidal anti-inflammatory tshuaj tiv thaiv.

Kev yoo mov tseem yuav ua rau muaj kev pheej hmoo hauv ntshav qab zib hauv cov neeg mob, thiab cov tshuaj xws li reserpine nrog clonidine daim npog nws.

Nyob rau hauv rooj plaub uas cov neeg mob tau phais mob, yog tias lawv kub hnyiab, raug mob, kis mob nrog kub taub hau, nrog rau myalgia, lactic acidosis, kev txiav tawm tam sim ntawd ntawm cov tshuaj yog qhov yuav tsum tau ua.

Cov tshuaj yuav cuam tshuam kev tsav tsheb. Kev saib xyuas yuav tsum ua.

Nws yog qhov yuav tsum tau tsum tsis txhob noj Glimecomb 2 hnub ua ntej thiab tom qab nkag mus rau hauv tus neeg mob lub cev radiopaque tus neeg sawv cev nrog iodine.

Phiv thiab haus tshaj

Ntawm cov kev phiv uas tshwm sim vim kev siv tshuaj yeeb muaj peev xwm ua tau:

hypoglycemia nrog hws hnyav, tsis muaj zog, kiv taub hau, tshaib plab thiab tsaus muag,
lactic acidosis nrog kev ua haujlwm tsis txaus, tsis muaj ntshav siab, ua kom tsis muaj zog, mob plab, myalgia,
xeev siab
anemia
teeb meem tsis pom kev
urticaria
kev tsis haum vasculitis,
zawv plab
khaus
hemolytic anemia,
khaus
erythropenia
Nyob rau hauv tsawg zaus, kab mob siab,
daim siab ua hauj lwm.

Cov tsos mob tshwm sim feem ntau ntawm kev noj ntau tshaj yog hypoglycemia thiab lactic acidosis. Cov tsos mob ob leeg xav tau kev kho mob sai sai hauv tsev kho mob. Hauv ob qho xwm txheej, cov tshuaj yog nres. Hauv thawj kis, tus neeg mob tau txais kev kho mob, kho mob ntshav kuaj ntshav.

Nrog rau cov ntshav qog ntshav qab zib me thiab mob nruab nrab, nws yog qhov txaus rau cov neeg mob coj kev daws ntawm cov piam thaj sab hauv. Hauv cov foos hnyav, cov piam thaj yog tswj cov leeg ntawm tus neeg mob (40%). Lwm txoj hauv kev yuav yog glucagon, muab ob qho tib si ntawm intramuscularly thiab subcutaneously. Kev kho ntxiv yog siv nrog tus neeg mob noj cov khoom noj uas muaj carbohydrate.

Kev sib cuam tshuam txog Yeeb Tshuaj thiab Analogs

Cov tshuaj cuam tshuam nrog lwm cov tshuaj raws li hauv qab no:

cov nyhuv hypoglycemic yog qhov zoo dua thaum noj ua ke nrog enalapril, cimetidine, miconazole, clofibrate, ethionamide, anabolic steroids, cyclophosphamide, tetracycline, reserpine thiab lwm yam tshuaj nrog cov nyhuv hypoglycemic,
txo cov nyhuv hypoglycemic thaum noj ua ke nrog Clonidine, Phenytoin, Acetazolamide, Furosemide, Danazole, Morphine, Glucagon, Rifampicin, nicotinic acid nyob rau hauv cov koob tshuaj loj, tshuaj estrogen, lithium ntsev, tshuaj tiv thaiv kab mob hauv qhov ncauj,
siv cov khoom tsis haum nrog nifedipine ua rau qhov txo qis ntawm metformin,
kev koom ua ke nrog cov neeg sawv cev ua haujlwm txhawm rau nce qhov siab tshaj plaws ntawm metformin hauv cov ntshav los ntawm 60%,
tsub kom cov ntsiab lus ntawm metformin co-administration ntawm cov tshuaj nrog furosemide.

Glimecomb muaj analogues thiab cov lus ua tau:

Glidiab
Glyformin
Glidiab MB
Gliformin Prolong,
Metglib
Rau feeb,
Gliclazide MB,
Lawbalong
Gliclazide-Akos.

Cov tshuaj yeeb yaj kiab qhia cov tsos mob thiab kev kho mob ntshav qab zib:

Kev xav ntawm cov kws tshaj lij thiab cov neeg mob

Los ntawm kev tshuaj xyuas cov neeg mob, nws tuaj yeem xaus lus tias Glimecomb txo cov ntshav qab zib kom zoo thiab muaj kev zam zoo, txawm li cas los xij, cov kws kho mob hais kom nws ceev faj vim muaj ntau cov kev mob tshwm sim.

Glimecomb yog ib qho kev kho mob zoo rau hom ntshav qab zib hom 2. Tab sis muab ntau yam contraindications rau nws, nws raug nquahu tias nws yuav tsum tau txiav txim nrog ceev faj rau ntau tus neeg mob. Tshwj xeeb cov neeg laus.

Anna Zheleznova, 45 xyoo, endocrinologist

Cov tshuaj zoo tswj ntshav qab zib. Kuv coj nws mus ib hlis, tsis muaj kev mob tshwm sim, txawm hais tias muaj ntau ntawm lawv hauv cov lus qhia. Txaus siab nrog tus nqi.

Kuv tau raug kev txom nyem los ntawm hom 2 ntshav qab zib rau qee lub sijhawm. Kuv txais Glimecomb. Cov tshuaj zoo thiab tsis kim heev. Nws txo cov piam thaj zoo. Qhov loj tshaj plaws yog noj kom zoo thiab noj kom raug.

Txog kev kho mob pob qij txha, peb cov neeg nyeem tau siv DiabeNot siv tau zoo. Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

Cov tshuaj uas tshwj xeeb yog faib los ntawm cov tshuaj. Nws tus nqi yog li ntawm 440-580 rubles. Tus nqi ntawm lwm cov khoom lag luam hauv tsev yog ntawm 82 txog 423 rubles.

Yuav siv cov Amaryl ntsiav tshuaj li cas thiab seb lawv tuaj yeem hloov li cas

Amaril yog suav tias yog nrov ntawm cov neeg mob ntshav qab zib. Nws txoj kev txais tos tso cai rau cov neeg mob tuaj yeem tswj hwm lawv tus mob, txo qis qhov ntxim nyiam ntawm kev tsim hyperglycemia. Cov tshuaj uas kws kho mob muab rau noj rau cov neeg mob ntshav qab zib hom II xwb.

Cov tshuaj nquag ntawm Amaril yog glimepiride. Cov tshuaj ntawm cov ntsiav tshuaj tseem suav nrog cov khoom sib txuas. Lawv cov npe yuav nce raws qhov ntau npaum ntawm glimepiride. Ib qho sib xyaw ua ke ntawm cov tshuaj ntxiv hauv cov ntsiav tshuaj yog vim xim sib txawv.

INN (npe thoob ntiaj teb): glimepiride (Latin Glimepiride).

Amalil M1, M2 kuj tseem muag hauv khw muag tshuaj. Ntxiv rau glimepiride, cov tshuaj muaj pes tsawg leeg suav nrog metformin hauv qhov ntau npaum li 250 lossis 500 mg, feem. Cov tshuaj sib txuam no tej zaum yuav raug kho los ntawm tus kws kho mob endocrinologist nkaus xwb.

Daim ntawv tso tawm

Amaryl yog muag hauv ntsiav tshuaj daim ntawv. Xim nyob ntawm qhov ntau npaum ntawm cov tshuaj nquag:

1 mg glimepiride - liab dawb,
2 - ntsuab
3 - lub teeb daj
4– xiav.

Lawv txawv nyob rau hauv cov cim sau tseg rau ntawm cov ntsiav tshuaj.

Pharmacological kev txiav txim

Glimepiride muaj cov nyhuv hypoglycemic rau ntawm lub cev. Nws yog ib qho muab sib txuas ntawm peb tiam sulfonylurea.

Amaryl muaj cov ntsiab lus ncua ntev. Thaum cov ntsiav tshuaj siv, tus kws kho mob txiav lub siab, thiab beta-cells qhib kom ua haujlwm. Raws li qhov tshwm sim, insulin pib tawm ntawm lawv, cov tshuaj hormone nkag mus rau hauv cov hlab ntshav. Qhov no pab txo qis cov piam thaj tom qab noj mov.

Tib lub sijhawm, glimepiride muaj cov nyhuv ntxiv. Nws tsub kom rhiab ntawm cov leeg, cov nqaij rog ua rau cov insulin. Thaum siv cov tshuaj, cov tshuaj tiv thaiv kev phom sij, antiatherogenic, cov nyhuv antiplatelet yog pom.

Amaril txawv ntawm lwm cov sulfonylurea derivatives uas thaum nws siv, cov ntsiab lus ntawm tso tawm insulin yog qis dua thaum siv lwm cov tshuaj hypoglycemic. Vim qhov no, txoj kev pheej hmoo ntawm hypoglycemia muaj tsawg heev.

Ntxiv dag zog rau cov txheej txheem ntawm kev siv cov piam thaj nyob rau hauv cov leeg nqaij thiab cov nqaij rog ua tau vim tias muaj qhov tshwj xeeb thauj cov protein nyob hauv cov cell ua cov qog. Amaryl tsub kom lawv cov haujlwm ntau ntxiv.

Cov tshuaj yeeb yaj kiab tsis thaiv ATP-nkag siab poov tshuaj raws ntawm plauv nres myocytes. Lawv tseem muaj txoj hauv kev hloov kho rau cov mob ischemic.

Amaryl kev kho mob thaiv kev tsim cov kua nplaum los ntawm lub siab ua haujlwm. Cov txiaj ntsig tau taw qhia yog vim muaj cov ntsiab lus nce ntxiv ntawm fructose-2,6-biophosphate hauv hepatocytes. Qhov tshuaj no nres gluconeogenesis.

Cov tshuaj pab txhawm rau txhawm rau txhawm rau lub zog ntawm cyclooxygenase, kom txo cov txheej txheem ntawm kev hloov pauv ntawm thromboxane A2 los ntawm arachidonic acid. Vim tias qhov no, kev siv ntawm platelet aggregation tsawg dua. Hauv qab ntawm Amaril, qhov hnyav ntawm cov tshuaj tiv thaiv oxidative, uas tau pom hauv cov ntshav qab zib tsis yog-insulin, txo qis.

Sau tshuaj rau cov tshuaj glimepiride rau cov neeg mob uas muaj tus mob II, yog tias kev siv lub cev, kev noj haus tsis tso cai rau koj tswj qib qab zib.

Cov lus qhia rau kev siv qhia tau tias nws raug tso cai rau kev sib xyaw ua ke siv tshuaj Amaril nrog metformin, kev txhaj tshuaj insulin.

Dr. Bernstein pom zoo tias kev teem sijhawm rau cov neeg sawv cev hypoglycemic tsis yog qhov muaj tseeb, txawm tias muaj qhov qhia tau rau kev siv. Nws hais tias cov tshuaj muaj teeb meem, txhim kho cov teeb meem hauv lub cev hauv lub cev tsis ua haujlwm. Txhawm rau qhov xwm txheej kom zoo, koj tuaj yeem siv tsis yog sulfonylurea derivatives, tab sis kev noj zaub mov hauv kev sib xyaw nrog kev kho tshwj xeeb.

Cov Yuav Tsum Tau Ua

Amaril yuav tsum tsis txhob raug sau tseg rau cov neeg mob uas:

insulin dependence
ketoacidosis, mob ntshav qab zib tsis xeev,
lub raum tsis ua haujlwm (suav nrog yog muaj mob xav tau hemodialysis),
malfunctioning ntawm daim siab,
tus tib neeg tsis kam txais lossis tso tshuaj lom rau glimepiride, excipients, lwm yam tshuaj ntawm sulfonylurea pawg,
cov me nyuam muaj hnub nyoog.

Cov kws kho mob yuav tsum tsis txhob sau cov tshuaj rau cov neeg mob uas tsis zoo, noj zaub mov tsis xwm yeem, txwv cov calories kom tsawg, noj tsawg dua 1000 kcal. Contraindication yog ib qho ua txhaum ntawm cov txheej txheem ntawm kev nqus ntawm cov khoom noj los ntawm txoj hnyuv huam.

Cov lus sib xyaw thiab daim ntawv ntawm cov tshuaj

Metformin hydrochloride yog suav tias yog thawj qhov kev ua haujlwm ntawm cov tshuaj. Raws li cov khoom siv ntxiv yog:

magnesium stearate,
povidone
microcrystalline fiber
hypromellose (2820 thiab 2356).

Tus neeg sawv cev rau kev kho mob muaj nyob rau hauv hom tshuaj, cov ntsiav tshuaj nrog qhov ntau npaum ntawm cov khoom tseem ceeb hauv cov nyiaj 500, 850 thiab 1000 mg. Cov tshuaj ntshav qab zib Biconvex Glucophage yog elliptical.

Lawv tau them nrog ib txheej tiv thaiv ntawm lub plhaub dawb. Ntawm ob sab, cov kev pheej hmoo tshwj xeeb yog siv rau cov ntsiav tshuaj, ntawm ib qho ntawm lawv txoj kev noj tshuaj yog qhia.

Sab sij huam

Ua ntej koj pib noj tshuaj Amaril, koj yuav tsum paub koj tus kheej nrog cov lus tseem ceeb rau cov tshuaj. Cov neeg mob yuav tsum paub dab tsi tuaj yeem tshwm sim.

Cov kev mob tshwm sim tshaj plaws suav nrog cov teeb meem hauv metabolism. Tus neeg mob yuav pib txhim kho hypoglycemia sai sai tom qab noj cov ntsiav tshuaj. Nyob hauv tsev, tus mob no nyuaj rau qhov ib txwm ua, koj yuav xav tau kev pab ntawm kws kho mob. Tab sis ib qho kev poob qis hauv cov ntshav hauv lub ntsej muag yog pom muaj tsawg zaus, tsis ntau tshaj li ntawm 1 tus neeg mob ntawm 1000 tus.

Thaum noj Amaril, tseem muaj cov teeb meem zoo li no los ntawm:

Lub plab zom mov: kev mob plab zom mov, kev tshaib plab, mob mob hauv lub epigastrium, daj ntseg, xeev siab, mob siab, txhim kho daim siab ua haujlwm,
hematopoietic plab hnyuv siab raum: thrombocytopenia, agranulocytosis, erythrocytopenia, leukopenia,
cov hlab ntsha hauv lub cev: nce siab zog, nkees, mob taub hau, nce kev ntxhov siab, txhoj puab heev, hais lus tsis meej, tsis meej pem, paresis, mob pob txha caj qaum, ntsej muag zoo li khaub thuas lo,
plab hnyuv siab raum tsis pom kev: hloov pauv vim hloov pauv hauv cov ntshav qab zib.

Qee tus pib tsim cov tshuaj tiv thaiv tsis haum. Cov neeg mob yws ntawm khaus, qhov tshwm sim ntawm daim tawv nqaij ua pob, urticaria, ua xua vasculitis. Feem ntau, cov kev mob tshwm sim no yog mob sib khuav xwb, qee tus neeg mob, tsis tuaj yeem txiav txim siab tsis quav tshuaj.

Noj ntau dhau

Amaryl yuav tsum tau noj nyob rau hauv cov nyiaj uas kws kho mob sau tseg. Overdose dhau los ua qhov ua kom ntshav qab zib tsawg. Qee qhov kev poob qab zib hauv qab zib qee zaum provokes mob ntshav qab zib coma.

Yog tias qhov kev tso cai noj tau ntau dhau, xeev siab, ntuav, mob epigastric tshwm sim. Ntau cov kev mob tshwm sim tuaj yeem tshwm sim:

pom kev pom
tsaug zog
tshee hnyo
cramps
coma
teeb meem kev sib koom tes.

Nyob rau hauv rooj plaub ntawm overdose, nws yog ib qhov tsim nyog los yaug lub plab. Tom qab kev ua kom huv huv muab cov enterosorbents. Nyob rau tib lub sijhawm, cov kua nplaum khov kho yog muab tso rau hauv cov tshuaj pleev ib ce. Ntxiv kev cai ntawm kev nqis tes ua tau tsim nyob ntawm tus neeg mob lub sijhawm. Thaum muaj mob hnyav, tus neeg mob pw hauv tsev kho mob chav tsev kho mob hnyav.

Kev sib txuam

Ua ntej muab cov tshuaj Amaryl, tus kws kho mob yuav tsum xyuas seb cov tshuaj twg tus neeg mob tau noj. Qee cov tshuaj txhim kho, lwm tus txo cov nyhuv hypoglycemic ntawm glimepiride.

Thaum ua kev tshawb fawb, nws pom tias qhov txo qis hauv cov ntshav qab zib tau pom thaum noj:

cov tshuaj tiv thaiv kab mob hauv qhov ncauj
Phenylbutazone
Oxyphenbutazone,
Azapropasone
Sulfinpyrazone,
Metformin
Tetracycline
Miconazole
salicylates,
MAO inhibitors
txiv neej nrog txiv neej cov tshuaj hormones
anabolic tshuaj yuam
quinol tshuaj tua kab mob,
Clarithromycin
Fluconazole
pab daws qhov teeb meem,
fibrates.

Yog li, nws tsis pom zoo kom pib haus Amaryl ntawm koj tus kheej yam tsis tau txais kev tsim nyog los ntawm kws kho mob.

Cov kab mob hauv qab no tsis muaj zog ntawm glimepiride:

progestogens
estrogens
thiazide diuretics,
tshuaj pleev
glucocorticoids,
nicotinic acid (thaum siv ntau koob),
laxatives (muab lub sij hawm ntev siv),
barbiturates
Rifampicin,
Glucagon.

Xws li cov nyhuv yuav tsum tau coj mus rau hauv tus account thaum xaiv ntau npaum.

Sympatolytics (beta-blockers, reserpine, clonidine, guanethidine) muaj qhov tshwm sim uas tsis paub txog ntawm qhov kev xav hypoglycemic ntawm Amaril.

Thaum siv coumarin derivatives, ceeb toom: glimepiride ua kom zoo dua qub lossis txo qhov cuam tshuam ntawm cov tshuaj no rau hauv lub cev.

Tus kws kho mob xaiv cov tshuaj rau ntshav siab, tsis-steroidal anti-inflammatory tshuaj, thiab lwm yam tshuaj uas nrov.

Amaryl ua ke nrog cov tshuaj insulin, metformin. Qhov kev sib xyaw no yog xav tau thaum thaum noj glimepiride nws tsis tuaj yeem ua kom tiav qhov kev xav tau tswj kev zom zaubmov. Qhov ntau thiab tsawg ntawm txhua yam tshuaj yog kws kho mob tau teev tseg.

Hauv qee kis, cov kws kho mob pom zoo kom haus cov dej Yanumet thiab Amaril tib lub sijhawm. Nrog rau txoj kev kho no, tus neeg mob tau txais:

Cov kev sib xyaw ua ke ntawm cov khoom xyaw nquag tuaj yeem txhim kho txoj hauv kev ntawm kev kho, pab tswj tau qhov mob zoo dua rau tus mob ntshav qab zib.

Hnub tas sij hawm

Siv cov tshuaj yog tso cai rau 36 lub hlis txij li hnub tso tawm.

Qhov tsim nyog endocrinologist yuav tsum xaiv qhov hloov pauv txoj cai rau Amaryl. Nws tuaj yeem sau tshuaj ib qho analogue ua tau los ntawm cov khoom zoo tib yam, lossis xaiv cov tshuaj uas ua los ntawm lwm cov khoom siv.

Cov neeg mob tuaj yeem sau npe yuav hloov kho Lavxias, Diamerid, uas yog pheej yig. Rau 30 ntsiav tshuaj ntawm cov tshuaj, ua rau lub hauv paus ntawm glimepiride, nrog cov tshuaj ntawm 1 mg rau hauv lub tsev muag tshuaj, cov neeg mob yuav them 179 p. Nrog txoj kev nkag ntawm qhov kev kub siab ntawm cov tshuaj nquag, tus nqi nce ntxiv. Rau diamerid hauv ib qho tshuaj 4 mg, 383 p.

Yog tias tsim nyog, hloov Amaryl nrog cov tshuaj Glimepiride, uas yog tsim los ntawm cov tuam txhab Lavxias teb sab Vertex. Cov tshuaj no tsis muaj nuj nqis. Rau ntim ntawm 30 pcs. 2 mg yuav tau them 191 p.

Tus nqi ntawm Glimepiride Canon, uas tsim los ntawm Canonfarm, kuj tseem qis dua. Tus nqi ntawm ib pob ntawm 30 ntsiav tshuaj ntawm 2 mg yog suav tias yog pheej yig, nws yog 154 p.

Yog tias glimepiride tsis qaug rau, cov neeg mob tau kho lwm yam tshuaj ntxiv raws ntawm metformin (Avandamet, Glimecomb, Metglib) lossis vildagliptin (Galvus). Lawv raug xaiv coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob lub cev.

Cawv thiab Amaryl

Nws tsis tuaj yeem kwv yees ua ntej li cas haus cawv muaj cawv yuav cuam tshuam rau tus neeg uas siv tshuaj yaj yeeb raws li glimepiride. Cov cawv yuav ua rau lub cev tsis muaj zog lossis txhim kho hypoglycemic ntawm Amaril. Yog li, lawv tuaj yeem siv tsis tau tib lub sijhawm.

Kev siv tshuaj hypoglycemic nyob ntev. Vim tias qhov no, txoj cai txwv tsis pub haus cawv haus cawv ntau rau ib qho yuav dhau los ua teeb meem.

Cev xeeb tub, lactation

Yuav siv tsis tau lub sij hawm thaum xeeb tus me nyuam hauv plab nruab cev, pub mis noj rau tus me nyuam yug tshiab, sulfonylurea derivatives yuav siv tsis tau. Hauv cov ntshav ntawm tus poj niam cev xeeb tub, cov kua nplaum nyob hauv lub cev yuav tsum tsis pub dhau. Tom qab tag nrho, hyperglycemia ua rau kev nce hauv kev pheej hmoo ntawm kev tsis txaus ntseeg lub neej tom qab, nce tus menyuam kev tuag ntau dua.

Cov poj niam cev xeeb tub tau pauv mus rau cov tshuaj insulin. Nws yog qhov ua tau kom tshem tawm qhov tshwm sim ntawm kev siv tshuaj phiv rau ntawm tus menyuam hauv utero yog tias koj tso sulfonylurea nyob rau theem ntawm kev npaj lub tswv yim.

Thaum lub sijhawm lactation, Txoj kev kho Amaril yog txwv tsis pub. Cov tshuaj nquag kis mus rau niam mis, lub cev ntawm tus menyuam yug tshiab. Thaum pub niam mis, nws yog qhov tsim nyog kom tus poj niam hloov mus rau kev siv tshuaj insulin.

Rau ntau tus neeg mob, kev pom zoo ntawm tus kws kho endocrinologist tsis txaus kom pib haus ib yam tshuaj tshiab. Cov kws kho mob hais tias cov tshuaj pab rau cov neeg ua haujlwm kom tsim cov tshuaj insulin, thaum nce ntxiv rhiab ntawm cov ntaub so ntswg mus rau nws. Qhov no ua rau kom pom tseeb tias cov piam thaj tau pib nqus nws lub cev.

Tab sis cov neeg mob xav hnov qhov kev xav txog cov tshuaj kws kho mob los ntawm lwm cov ntshav qab zib. Lub siab xav paub txog kev tshuaj xyuas ntawm lwm tus neeg mob vim yog tseem muaj nqi ntau ntawm cov tshuaj. Tom qab tag nrho, nws muaj ntau yam tshuaj ntawm kev muag khoom uas tau tsim los txo cov piam thaj hauv siab, tus nqi ntawm uas tau nqis qis dua.

Thaum noj Amaril rau 1-2 xyoo, tsis muaj qhov tsis zoo tshwm sim. Kev xyaum qhia tau tias ob peb ntsib teeb meem thaum siv cov tshuaj. Ntau zaus, teeb meem tshwm sim thaum Amaril M siv rau kev kho mob, uas ntxiv rau glimepiride suav nrog metformin. Cov neeg mob yws yws ntawm lub cev ua pob, ua pob khaus ntawm daim tawv nqaij, ua kom tawg. Tom qab noj cov ntsiav tshuaj, qee cov neeg xav tias muaj kev kub ntxhov hypoglycemic nce mus txog, txawm tias thaum kuaj xyuas nws hloov tawm tias qhov txo qis cov piam thaj tsis tseem ceeb.

Hauv thawj lub hlis ntawm kev siv, glimepiride npaj zoo kawg nkaus txo qis qab zib. Tab sis qee tus kws kho mob tau sau tseg tias qhov ua tau zoo ntawm cov tshuaj pib qhuav zuj zus thaum lub sijhawm dhau mus. Tus neeg mob yog thawj zaug nce ntxiv qhov ntau npaum li cas, thiab tom qab ntawd ua ke los ntawm kev siv tshuaj yog kho. Nov yog tib txoj hauv kev kom ua tiav lub xeev ib ntus. Tab sis vim tias qhov txo qis hauv txoj hauv kev kho tau zoo, tus neeg mob tau nce siab nyob hauv qab zib hauv lub cev. Qhov no ua rau muaj kev cuam tshuam dav dav.

Nrog kev pab los ntawm Amaril, qee tus neeg mob ntshav qab zib tau maj mam tau txais ntawm qhov xav tau los ua cov tshuaj insulin tas li. Txawm hais tias thaum pib ntawm kev kho mob, ntau tus neeg muaj cov tsos mob ntawm lub qog ntshav qab zib. Cov neeg mob yws txog xeev siab, ua tsis taus tes, dias taub hau, muaj kev tshaib plab tas li. Maj mam, qhov mob hloov kho, qhov tsis zoo tshwm sim ploj.

Nqe, qhov twg yuav

Amaryl ntsiav tshuaj muaj muag hauv yuav luag txhua txhua lub tsev muag tshuaj. Tus nqi ntawm ib pob ntawm 30 daim ncaj qha nyob ntawm kev muab tshuaj pom zoo los ntawm kws kho mob.

Tus nqi ntawm mg glimepiride	Tus nqi, tshiav.
1	348
2	624
3	939
4	1211

Pob khoom ntawm 90 ntsiav tshuaj muaj muag. Yog tias koj yuav Amaril nyob rau hauv xws li pob, koj yuav txuag tau me ntsis. Txhawm rau ntim khoom ntawm 90 daim (2 mg) koj yuav tsum them 1728 p.

Tus neeg mob ntshav qab zib kuj tseem yuav tau qhia kom saib xyuas tus nqi hauv cov chaw muag tshuaj sib txawv. Amaryl qee zaum muag thaum luv nqi.

Glucophage Ntev rau ntshav qab zib

Glucophage Ntev yog cov tshuaj metformin tshwj xeeb vim nws tus kheej kho tau ntev ntev.

Qhov tshwj xeeb kho cov tshuaj ntawm cov tshuaj no ua rau nws ua tiav cov txiaj ntsig ib yam li thaum siv metformin zoo tib yam, txawm li cas los xij, qhov cuam tshuam ntev mus ntev, yog li ntawd, nyob rau hauv Feem ntau nws yuav txaus siv Glucophage Ntev ib hnub ib hnub.

Qhov no txhim kho qhov ua kom haum siab ntawm cov tshuaj thiab qhov zoo ntawm lub neej ntawm cov neeg mob.

Qhov kev txhim kho tshwj xeeb uas siv rau hauv kev tsim cov ntsiav tshuaj tso cai rau cov haujlwm ua haujlwm kom raug tso rau hauv lub lumen ntawm txoj hnyuv tusyees thiab zoo ib yam, vim tias qhov zoo tshaj ntawm cov piam thaj kom tswj nyob ib ncig ntawm lub moos, tsis muaj kev dhia thiab tee.

Sab nraud, cov ntsiav tshuaj yog npog nrog zaj duab xis maj mam yaj sab hauv, sab hauv yog lub hauv paus nrog metformin ntsiab. Raws li daim nyias nyias maj mam yaj, cov tshuaj nws tus kheej raug tso tawm. Nyob rau tib lub sijhawm, kev mob plab hauv plab hnyuv thiab acidity tsis muaj kev cuam tshuam loj tshaj plaws nyob rau hauv chav kawm ntawm tso metformin tawm; hauv qhov no, qhov tshwm sim zoo tshwm sim hauv cov neeg mob sib txawv.

Ib-zaug siv Glucofage Ntev hloov cov kev siv niaj hnub rov qab ua dua ntawm cov metformin zoo tib yam. Qhov no tshem tawm qhov kev xav tsis txaus siab los ntawm txoj hnyuv plab, uas tshwm sim thaum noj cov tshuaj metformin, nyob rau hauv kev sib txuas nrog kev mob hnyav ntxiv rau nws cov concentration hauv cov ntshav.

Mechanism ntawm kev ua

Cov tshuaj yog zwm rau pab pawg ntawm biguanides thiab tau ua kom txo qis ntshav qab zib. Lub hauv paus ntsiab lus ntawm glucophage yog tias, los ntawm kev poob qis rau cov ntshav qabzib, nws tsis ua rau muaj kev kub ntxhov.

Tsis tas li ntawd, nws tsis nce insulin ntau lawm thiab tsis cuam tshuam rau cov piam thaj hauv cov neeg noj qab haus huv. Qhov peculiarity ntawm mechanism ntawm kev cuam tshuam ntawm glucophage yog ua raws li qhov tseeb tias nws txhim kho qhov rhiab ntawm receptors rau insulin thiab ua kom cov ntshav qab zib los ntawm cov leeg hlwb.

Txo cov txheej txheem ntawm kev txuam nrog cov piam thaj hauv cov qog, nrog rau kev zom zaub mov ntawm lub cev los ntawm cov zom zaub mov. Nws muaj cov txiaj ntsig zoo rau cov roj metabolism: nws txo cov roj cholesterol, triglycerides thiab lipoproteins tsawg ntom.

Lub bioavailability ntawm cov khoom tsis yog tsawg tshaj li 60%. Nws yog yaim sai dua ntawm phab ntsa ntawm lub plab zom mov thiab qhov loj tshaj plaws ntawm cov tshuaj hauv cov ntshav nkag 2 thiab ib nrab teev tom qab kev tswj hwm ntawm qhov ncauj.

Cov khoom ua haujlwm tsis cuam tshuam rau cov ntshav protein thiab kis mus sai rau cov kab mob ntawm lub cev. Nws yog kiag li tsis ua los ntawm daim siab thiab ua rau lub tso zis. Muaj kev pheej hmoo ntawm kev txwv tsis pub siv tshuaj hauv cov nqaij hauv cov neeg uas lub raum tsis ua haujlwm.

Leej twg yuav tsum tsis txhob noj cov tshuaj no?

Qee tus neeg mob noj Glucofage raug kev txom nyem los ntawm ib qho txaus ntshai - lactic acidosis. Qhov no tshwm sim los ntawm kev txuam nrog cov lactic acid hauv cov ntshav thiab feem ntau tshwm sim rau cov neeg uas muaj teeb meem lub raum.

Cov neeg feem coob uas raug tus mob no, cov kws kho mob tsis sau ntawv yuav yuav cov tshuaj no. Ntxiv rau, nws muaj lwm yam mob uas yuav ua rau muaj feem ntau lactic acidosis.

Cov no siv rau cov neeg mob uas:

teeb meem mob siab
lub plawv tsis ua hauj lwm
muaj kev haus dej tshuaj yeeb tshuaj,
Cev xeeb tub lossis lactation
npaj kev phais mob nyob ze yav tom ntej.

Dab tsi ntxiv lwm yam tshuaj cuam tshuam rau cov nyhuv ntawm glucophage?

Tham nrog koj tus kws kho mob txog kev noj tshuaj rau tib lub sijhawm glucophage.

Nws tsis pom zoo kom muab cov tshuaj no tso nrog:

Kev siv cov tshuaj nram qab no nrog glucophage tuaj yeem ua rau hyperglycemia (ntshav qab zib), uas yog nrog:

phenytoin
tshuaj noj tiv thaiv cev xeeb tub lossis tshuaj kho hloov kho,
noj tshuaj kho mob lossis tshuaj rau mob hawb pob, mob khaub thuas lossis ua xua,
diuretic ntsiav tshuaj
mob plawv los yog kub siab tshuaj,
niacin (Tus Kws Pab Tswv Yim, Niaspan, Niacor, Simcor, Srb-niacin, thiab lwm yam),
phenothiazines (Compazin li al.),
steroid txoj kev kho (prednisone, dexamethasone thiab lwm tus),
Cov tshuaj hormones rau cov thyroid caj pas (Synthroid thiab lwm tus).

Cov npe no tsis tiav. Lwm yam tshuaj yuav tuaj yeem nce lossis txo cov txiaj ntsig ntawm glucophage ntawm kev txo cov ntshav qab zib.

Cov Lus Nquag Nug

Yuav muaj dab tsi yog tias kuv ncua tsis tau noj?

Noj cov tshuaj uas ploj lawm kom sai li sai tau koj nco qab (nco ntsoov noj cov tshuaj nrog zaub mov). Hla lub tshuaj uas koj tsis nco qab yog tias lub sijhawm ua ntej koj txoj kev npaj tshuaj txuas ntxiv yog luv. Nws tsis pom zoo kom noj ntxiv rau qhov tshuaj rau lub sijhawm ploj.

Yuav ua li cas yog koj noj ntau dhau?

Kev siv ntau tshaj ntawm metformin tuaj yeem ua rau kev txhim kho ntawm cov kab mob lactic acidosis, uas tuaj yeem ua rau neeg tuag taus.

Kuv yuav tsum tau zam dab tsi thaum noj cov tshuaj glucophage?

Zam txhob haus cawv. Nws ua rau nws cov ntshav qab zib tsawg thiab yuav muaj feem ua mob lactic acidosis thaum noj tshuaj Glucofage.

Glucophage los ntawm ntshav qab zib: tshuaj xyuas

Txheeb xyuas cov duab dav dav ntawm kev muaj mob ntshav qab zib nyob hauv qab ntawm glucophage, ib qho kev tshawb fawb tau tshawb pom ntawm cov neeg mob. Los ua kom yooj yim ntawm cov txiaj ntsig, qhov kev txheeb xyuas tau muab faib ua peb pawg thiab cov hom phiaj feem ntau raug xaiv:

Kuv tau mus cuag kws kho mob nrog qhov teeb meem ntawm kev poob phaus sai dua li qhov tsis muaj zaub mov noj thiab ua si lub cev, thiab tom qab kev kuaj mob kuv tau kuaj mob insulin tsis kam thiab hypothyroidism, uas ua rau muaj qhov hnyav. Kuv tus kws kho mob tau hais kom kuv siv tshuaj metformin ntau kawg ntawm 850 mg 3 zaug hauv ib hnub thiab pib kho cov thyroid caj pas. Tsis pub dhau 3 lub hlis, qhov hnyav tsim thiab lub zog insulin rov qab los. Kuv tau teem sijhawm coj Glucofage mus tas kuv lub neej.

Xaus: kev siv cov glucophage muab cov txiaj ntsig zoo nrog kev txhaj tshuaj ntau.

Glucophage tau noj 2 zaug hauv ib hnub nrog nws tus poj niam. Kuv tu ob peb zaug. Kuv txo qis kuv cov ntshav qab zib ib zaug, tab sis cov kev mob tshwm sim txaus ntshai. Txo cov koob tshuaj metformin. Ua ke nrog kev noj haus thiab kev tawm dag zog, cov tshuaj txo cov ntshav qab zib, Kuv xav hais tias, los ntawm 20%.

Xaus: hla kev noj tshuaj ua rau muaj kev phiv.

Npaj siab kwv yees li ib hlis dhau los, tsis ntev los no kuaj mob ntshav qab zib hom 2. Coj mus rau peb lub lis piam. Cov kev mob tshwm sim tsis muaj zog thaum xub thawj, tab sis sib zog ntau heev ua rau kuv xaus rau hauv tsev kho mob. Nres tau noj nws ob hnub dhau los thiab maj mam rov qab muaj zog.

Txog kev kho mob pob qij txha, peb cov neeg nyeem tau siv DiabeNot siv tau zoo. Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

Xaus: tus tsis kam txais ntawm cov tshuaj yeeb dej caw