Cov lus qhia rau kev siv "Trazhenty", muaj pes tsawg leeg, sib txuam, nqi thiab tshuaj xyuas cov kws kho ntshav qab zib

Cov tshuaj yog tawm rau kev siv rau cov neeg laus thaum muaj mob ntshav qab zib hom 2.

Kev kho mob monotherapy nrog rau cov tshuaj yog qhia nyob rau hauv rooj plaub thaum kev ua kom lub cev thiab ua kom lub cev noj qab haus huv tsis tau tso cai rau kev tswj cov ntshav qabzib. Nws yog qhov ua tau kom noj cov ntsiav tshuaj nrog kev tsis txaus ntseeg rau qee yam khoom muaj nqis xws li metformin lossis muaj qhov tsis sib haum rau nws qhov kev nkag.

Kev kho ua ke (yog tias kev noj zaub mov zoo thiab ua kom lub cev tsis ua haujlwm):

• Ua ke nrog metformin,
• Nrog sulfonylurea zoo li metformin
• Nrog rau cov tshuaj insulin thiab metformin.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Hauv cov ntsiav tshuaj Trazent, muaj tib lub tshuaj tiv thaiv tsuas yog sawv cev los ntawm linagliptin, nws cov peev txheej loj hauv cov tshuaj yog 5 mg. Lwm yam muaj nyob:

• Pob kws nplej siab
• Mannitol
• Magnesium stearate
• Npog Cov Paj Yeeb Opadry.

Ntsiav tshuaj txaus 5 mg ntawm lub xim liab plooj nrog beveled npoo, ntawm ib sab muaj qhov cim "D5". Cov tshuaj yog muab tso rau hauv lub hlwv ntim ntawm 7 pcs. Sab hauv lub pob muaj 5 pob.

Kho thaj chaw

Cov tshuaj nquag ua haujlwm Trazhenty yog ib ntawm cov tsis haum ntawm qee yam enzyme dipeptidyl peptidase-4. Raws li cov tshuaj ntawm cov tshuaj no, kev rhuav tshem cov tshuaj hormones incretin raug pom, uas suav nrog HIP, nrog rau GLP-1 (lawv ua rau kev tswj hwm ntawm cov suab thaj ntau ntau).

Cov concentration ntawm cov tshuaj hormones nce yuav luag tam sim ntawd tom qab noj mov. Yog tias nyob rau hauv cov ntshav muaj ntshav qabzib ib txwm muaj lossis nce siab me ntsis, tom qab ua li HIP thiab GLP-1, kev ua kom sai ntawm cov tshuaj insulin yog soj ntsuam, nws zoo dua zais cia los ntawm tus txiav. Ntxiv rau, GLP-1 inhibits cov txheej txheem ntawm cov kua nplaum tsim tawm ncaj qha rau hauv lub siab.

Kev sib piv ntawm cov tshuaj Tredent thiab cov tshuaj nws tus kheej nce qib ntawm nce, nyob rau hauv kev cuam tshuam ntawm cov tshuaj, lawv cov kev ua ub no (nce hauv kev sib txuas ntawm cov tshuaj insulin).

Nws tsim nyog sau cia tias cov tshuaj pab txhawb kev nce ntxiv hauv cov piam thaj ntawm cov kua dej insulin ntau lawm, thaum txo qis cov qog ntshav qabzib, vim tias qhov no, cov piam thaj hauv ntshav yuav rov qab zoo li qub.

Daim ntawv qhia: cov lus qhia ua tiav rau kev siv

Nqe: los ntawm 1610 txog 1987 rubles.

Nws raug nquahu kom siv 1 lub tshuaj ib hnub ib zaug. Daim Ntawv Thov Terzety tuaj yeem nqa tawm tsis hais tus noj mov.

Yog tias ib ntsiav tshuaj ntawm cov tshuaj hypoglycemic tau ploj lawm, koj yuav tsum tau noj tam sim ntawd, raws li koj nco qab txog daim ntawv hla. Nws yog tsim nyog sau cia tias noj ob zaug tshuaj ntawm cov tshuaj nruab hnub.

Dosage kev kho rau hauv cov tib neeg nrog pathologies ntawm lub raum, ntxiv rau hauv lub siab thiab hauv cov neeg laus, tsis yog nqa tawm.

Cov Kev Tsis Txaus Ntseeg thiab Kev Ceev Faj

Kev kho mob hypoglycemic yuav tsum tsis txhob pib nrog:

• Yam 1 ntshav qab zib
• Cov menyuam hnub nyoog (cov menyuam hnub nyoog qis dua 18 xyoo)
• Cov kev nkag siab rau cov tshuaj tseem ceeb lossis cov khoom siv ntxiv
• Ntshav qab zib ketoacidosis
• Cev xeeb tub, GV.

Kev siv tshuaj tsis zoo rau cov neeg muaj ketoacidosis, zoo li muaj tshuaj muaj ntshav qab zib insulin.

Txij li thaum sulfonylurea derivatives provoke kev txhim kho ntawm hypoglycemia, cov tshuaj yog kws kho nrog ceev faj heev nyob rau hauv cov ntaub ntawv ntawm kev sib txig sib luag. Yog tias tsim nyog, cov koob tshuaj no txo.

Txais linagliptin tsis ua rau kom muaj kev puas siab ntsws los ntawm CCC.

Ua ke nrog rau lwm cov tshuaj hypoglycemic, nws tuaj yeem raug xaj txawm tias lub raum tsis ua haujlwm.

Thaum noj tshuaj rau ntawm lub plab khoob, muaj qhov tseem ceeb hauv glycosylated hemoglobin thiab piam thaj.

Yog hais tias cov tshuaj noj los ntawm cov neeg laus cov neeg mob, txo qis glycated hemoglobin yog ua tau, thaum cov ntshav ceev ceev cov ntshav hauv lub cev txo.

Kev kho ntshav qab zib tsis cuam tshuam rau qhov nce ntawm kev pheej hmoo mob plawv.

Qee qhov xwm txheej, thaum kho nrog Trazhenta, kev txhim kho ntawm tus mob huam sai tuaj yeem sau tseg. Ntawm thawj cov cim qhia ntawm tus kab mob, nws tsim nyog los ua kom tiav cov kev muaj peev xwm ntawm cov ntsiav tshuaj hypoglycemic thiab sab laj nrog kws kho mob.

Tawm tsam keeb kwm ntawm kev kho mob, qhov tshwm sim ntawm kiv taub hau tsis tau txiav txim siab, hauv qhov kev sib txuas no, kev saib xyuas tshwj xeeb yuav tsum tau coj thaum tsav tsheb cov txheej txheem meej, nrog rau cov tsheb.

Hla kev sib txuam yeeb tshuaj

Nrog rau kev siv ua ke ntawm ritonavir (ntau npaum 200 mg), nce ntxiv ntawm AUC thiab Cmax ntawm linagliptin nws tus kheej tau pom nyob hauv 2 r. thiab 3 p. raws li. Cov kev hloov pauv no tsis tuaj yeem hu ua qhov tseem ceeb, yog li tsis tas yuav muaj kev ua raws li kev hloov kho tau los ntawm cov tshuaj kho.

Thaum noj cov tshuaj rifampicin, AUC thiab Cmax txo mus rau 40-43%, txo qis hauv kev tawm tsam ntawm kev ua hle ntawm dipeptidyl peptidase-4 nws tus kheej tau pom muaj kwv yees li 40%.

Kev sim tib lub sij hawm nrog digoxin tsis muaj kev cuam tshuam tseem ceeb ntawm pharmacokinetics ntawm cov tshuaj nquag.

Linagliptin tuaj yeem cuam tshuam rau cov txheej txheem kev zom zaub mov, tab sis mus rau qee qhov me me. Thaum noj tshuaj, kev hloov pauv ntawm kev tshwm sim uas tshwm sim nrog kev koom tes ntawm CYP3A4 system, koj yuav tsum kho qhov koob tshuaj Trazhenta.

Phiv thiab haus tshaj

Thaum lub sij hawm txoj kev kho ntawm Trazhenta, kev txhim kho ntawm cov kev mob tshwm sim tuaj yeem pom, qhov no yog vim muaj cov tshuaj tiv thaiv ntawm lub cev. Muaj qee kis, pom qhov tshwm sim tsis zoo tsis txaus ua rau muaj qhov phom sij txaus ntshai, vim tias nws tau nyaij mus ua ib daim ntawv me.

Feem ntau qhov tsis zoo muaj xws li:

• Kev ntshav siab
• Kev tsim kho ntawm pancreatitis
• Qhov hnyav nce
• Mob taub hau thiab kiv taub hau heev
• Qhov pib ntawm nasopharyngitis
• Pob tw los ntawm hom urticaria
• Hnoos.

Thaum muaj cov xwm txheej tau piav no, koj yuav tsum tau sab laj ib tus kws kho mob kom tuaj yeem tawm tswv yim. Nyob rau hauv cov kev tshwm sim tsis zoo, cov tshuaj raug muab tso tseg, tsev kho mob yuav tsum.

Hauv qee kis, tus kws kho mob yuav qhia qhia hloov Trazent nrog analogues.

Cov rooj sib hais ntawm kev haus dej ntau dhau tsis tau sau tseg.

Thaum noj ntau tshaj ntawm Trazhenta, yuav tsum ua raws li kev tso dej tawm ntawm txoj hnyuv. Nws yog ib qho tsim nyog yuav tau soj ntsuam cov ntshav qab zib thiab coj tus cwj pwm kev kho mob nyob rau hauv kev saib xyuas ntawm tus kws tshaj lij.

MSD PHARMACEUTICALS, Tebchaws Netherlands

Nqi los ntawm 1465 txog 1940 rubles.

Januvia - cov tshuaj raws li sitagliptin, ua kom pom cov nyhuv ntawm lub ntsej muag hypoglycemic. Nws yog tshuaj rau kev kho hom 2 mob ntshav qab zib mellitus (ob qho tib si monotherapy thiab kev sib xyaw ua ke noj tshuaj). Muaj nyob hauv ntsiav tshuaj daim ntawv.

Pros:

• Yuav muab tshuaj rau cov neeg muaj lub siab pathologies
• Yooj yim ntsiav tshuaj tswj hwm
• Nws tuaj yeem noj tsis pub noj.

Cons:

• Tus nqi siab
• Tsis muaj cai tso rau cov menyuam hnub nyoog qis dua 18 xyoo
• Nws yuav tsum tsis txhob ua ke nrog cyclosporine.

Novartis Pharma, Switzerland

Nqi los ntawm 715 txog 1998 rub.

Cov tshuaj yog coj los kho mob ntshav qab zib (tshwm sim ntawm hypoglycemic kev ua). Lub ntsiab lus tseem ceeb ntawm Galvus - vildagliptin tshwj xeeb cuam tshuam rau tus txiav thiab tiv thaiv cov leeg dipeptidyl peptidase-4, vim tias muaj qhov txo qis hauv cov ntshav qab zib thiab cov tshuaj insulin zais cia. Cov tshuaj tau sau tseg rau hom ntshav qab zib hom 2, kev noj cov ntau ntawm cov tshuaj tau teeb tsa ua ib tus zuj zus. Galvus daim ntawv tso tawm yog ntsiav tshuaj.

Pros:

• Siv tau cov tshuaj metformin
• Zoo zam txim tau
• High bioavailability ntawm cov tshuaj nquag - 85%.

Cons:

• Contraindicated hauv plawv nres
• Yuav tsum tsis txhob xyaw nrog cawv
• Kev kho mob tau zoo tsuas yog noj zaub mov nkaus xwb.

Pharmacodynamic thiab pharmacokinetic muaj

Linagliptin yog ib qho inhibitor ntawm qhov enzyme DPP-4. Nws pab kom tsis txhob muaj cov tshuaj hormones nce zuj zus - GLP-1 thiab ISU. Lub enzyme DPP-4 tua cov tshuaj hormones no nrawm. Tus incretins tswj theem kev kawm lub cev ntawm cov piam thaj. GLP-1 thiab GUI qib yog qhov tsawg thaum nruab hnub, tab sis yuav nce siab tom qab noj mov. Cov nce ntxiv yuav txhawb cov tshuaj insulin biosynthesis thiab nws ua haujlwm ntawm cov txiav ua qab thaum lub cev nce siab thiab nce qib hauv qab zib. Tsis tas li ntawd, GLP ua cov txheej txheem uas thaiv qhov ua rau cov piam thaj los ntawm lub siab.

Linagliptin nkag mus rau hauv kev sib raug zoo nrog DPP-4, uas ua rau kom nce qib ntawm cov khoom nce thiab ua rau kom lawv muaj sia nyob ntev.

Tseem Ceeb! "Trazhenta" ua rau cov kua dej zais tsis muaj zog thiab txwv tsis pub cov khoom ntawm glucagon, uas ua rau kom muaj kev nyob ruaj khov ntawm cov piam thaj hauv lub cev.

Los ntawm qhov nws kho mob, thaum nws tuaj yeem tsim txom

Ntshav Qab Zib Hom 2:

• raws li kev kho kab mob rau cov neeg mob uas tsis muaj glycemia tsis zoo tswj cov keeb kwm yav dhau los ntawm kev noj zaub mov kev txwv thiab kev siv lub cev, nrog rau kev nkag tsis tau rau metformin lossis tsis muaj peev xwm siv nws los ntawm kev mob raum,
• raws li kev tiv thaiv kev kho mob ua ke nrog metformin, sulfonylurea derivative (SM) lossis thiazolidinedione, yog tias nws tsis hnov ​​mob siab los ntawm kev noj zaub mov zoo thiab kev tawm dag zog, lossis yog tias cov tshuaj saum toj no tsis muaj txiaj ntsig zoo li kev kho mob,
• raws li lub ntsiab ntawm txoj kev kho peb-xyaw nrog metformin thiab SM thaum tsis muaj kev noj haus zoo, kev tawm dag zog lossis kev sib koom tes ntawm cov tshuaj no.

Tsis tas li ntawd, hauv kev kho mob ntawm Trazenta ntshav qab zib mellitus, cov ntshav qab zib tau tso cai siv:

• tshuaj insulin
• metformin
• pioglitazone,
• sulfonylureas.

Nws yog txwv tsis pub siv cov tshuaj rau cov neeg uas raug kev txom nyem los ntawm:

• Yam 1 ntshav qab zib
• mob ketoacidosis,
• lub cev tsis haum rau lub cev ntawm "Trazhenty".

Tsis tas li, cov tshuaj yuav tsum tsis txhob siv hauv kev kho mob:

• cov menyuam nyob rau hauv kaum yim,
• poj niam muaj me nyuam
• saib xyuas cov niam tsev.

Teeb meem tshwm sim tuaj

Kev txhim kho cov kev mob tshwm sim yog qhov hnyav heev rau kev siv cov Trazenti.

1. Thaum lub caij mononotherapy, tus neeg mob tsim muaj: hypersensitivity, hnoos, pancreatitis, nasopharyngitis.
2. Kev sib xyaw nrog metformin provokes qhov tshwm sim ntawm kev ua haujlwm tsis haum, hnoos tawm tsam, nasopharyngitis, pancreatic o.
3. Yog hais tias tus neeg mob yuav siv cov tshuaj nrog SM, tom qab ntawd, ntxiv rau cov kev phiv sab saud, kev pheej hmoo ntawm kev txhim kho hypertriglyceridemia nce.
4. Lub sijhawm sib xyaw ua ke ntawm "Trazhenty" thiab pioglitazone tuaj yeem ua rau cov kev mob tshwm sim saum toj no, hyperlipidemia thiab qhov hnyav nce.
5. Nrog rau siv ua ke nrog cov tshuaj insulin, qhov yav tas los piav qhia qhov tshwm sim tsis zoo thiab cem quav yuav tshwm sim.
6. Kev siv cov kev tshaj tawm tuaj yeem ua rau mob angioedema ceeb, urticaria, tawm pob, thiab mob pancreatitis.

Tsuas noj cov sijhawm, cuam tshuam ntawm kev siv tshuaj ntau dhau

Cov ntsiav tshuaj noj ntawm qhov ncauj. Raws li txoj cai, qhov tshuaj rau txhua hnub yog 5 mg. Yog hais tias tus neeg mob yuav haus lawv nrog metformin, kev noj tshuaj ntawm cov tom kawg tseem zoo li qub.

"Trazhentu" tuaj yeem siv tau tsis hais txog kev xaiv zaub mov.

Yog tias tus mob ntshav qab zib tsis nco qab noj tshuaj, nws yuav tsum ua kom sai, tab sis tsis pub tshaj qhov koob tshuaj pom zoo.

Cov raum tsis ua haujlwm tsis tas yuav tsum kho qhov ntau thiab tsawg ntawm Trazenti.

Tus neeg mob ntshav qab zib uas tsis muaj peev xwm ua rau mob hepatic kuj tseem tuaj yeem siv ib qho tshuaj uas tsim nyog, tab sis lawv yuav tsum muaj kev saib xyuas tas mus li.

Cov kev tshawb fawb pom tias kev noj ntau tshaj txhua hnub los ntawm 120 zaug, uas yog, noj 600 mg ntawm cov tshuaj lag luam tsis ua rau muaj kev cuam tshuam tsis zoo hauv kev noj qab haus huv hauv cov neeg muaj kev noj qab haus huv.

Yog tias cov ntshav qab zib mob dhau mus vim tias qhov ntau dhau ntawm cov koob tshuaj, nws xav tau:

• tshem tawm cov tshuaj ntxiv rau ntawm lub plab zom mov,
• yauv mus kuaj mob
• siv cov tsos mob kev kho mob.

Tseem Ceeb! Tsuas yog tus kws tshaj lij yuav tsum txiav txim siab ntev npaum li cas tus neeg mob tuaj yeem siv "Trazhenta" yam tsis muaj kev cuam tshuam.

Ua ke nrog lwm cov tshuaj

Cov thawj coj ua ke ntawm Trazhenta nrog Metformin, txawm tias nyob ntawm ntau npaum li cas cov tshuaj, tsis ua rau muaj kev hloov pauv ntau yam hauv cov chaw muag tshuaj ntawm ob qho tshuaj.

Ib txhij tswj hwm nrog “Pioglitazone” kuj tsis cuam tshuam rau lub pharmacological yam ntxwv ntawm ob qho tshuaj.

"Trazhenta" tuaj yeem siv nrog "Glibenkamid", tsuas yog hauv qhov no qhov feem ntau qhov siab ntawm qhov kawg yuav raug me ntsis. Lwm yam tshuaj nrog sulfinyl urea yuav muaj cov cim zoo sib xws.

Kev sib xyaw ntawm "Trazhenty" nrog "Rifampiin" txo qhov kev xav ntawm thawj. Cov yam ntxwv ntawm Pharmacological tau khaws cia me ntsis, tab sis 100 feem pua ​​kev ua haujlwm yuav tsis nyob ntev.

Koj tuaj yeem siv Digoxin tib lub sijhawm uas Trazenta. Xws li kev sib xyaw ua ke tsis cuam tshuam rau cov chaw muag tshuaj ntawm cov tshuaj no. Cov txheej txheem zoo sib xws no tshwm sim nrog kev sib txuas ntawm linagliptin thiab Warfarin.

Qee qhov kev hloov pauv tau sau nrog kev tswj hwm ntawm linagliptin thiab Simvastatin.

Thaum siv Transit, cov neeg mob ntshav qab zib yuav siv OK.

Analogs thiab txhais tau ntawm cov tshuaj

Yog tias tus mob ntshav qab zib tsis tuaj yeem noj Trazent rau qee yam, yuav tsum hloov cov tshuaj.

Cov lus qhia tshwj xeeb

"Trazent" raug txwv tsis pub tshaj tawm rau T1DM thiab ketoacidosis (tom qab raug T1DM).

Cov kev tshawb nrhiav raug cai tau qhia tias hypoglycemia thaum siv tshuaj sib xyaw ua ke tsis yog tshwm sim los ntawm Transjet, tab sis los ntawm cov tshuaj metformin thiab thiazolidinedione tshuaj, los yog sulfinyl urea pawg tshuaj. Nrog qhov siab qhov teeb meem ntawm hypoglycemia, qhov ntau npaum ntawm tom kawg yuav tsum tau kho.

Linagliptin tsis muaj peev xwm ua rau CCC pathology. Ua ke nrog lwm cov tshuaj, nws tuaj yeem kho rau cov neeg mob kev txom nyem los lub raum kev ua haujlwm.

Hauv qee qhov mob ntshav qab zib, cov tshuaj tau ua rau mob hnyav ua rau muaj tus kab mob pancreatitis. Ntawm nws cov tsos mob thawj zaug (mob plab heev, mob tsis haum thiab tsis muaj zog ntau dua), tus mob ntshav qab zib yuav tsum tau so los ntawm kev siv Trazenti thiab sab laj tus kws kho mob tam sim ntawd.

Txog tam sim no, tsis muaj xov xwm hais txog cov nyhuv ntawm cov tshuaj ntawm lub peev xwm ntawm cov ntshav qab zib kom tswj tau ntau yam txheej txheem. Tab sis vim qhov tseeb hais tias tus neeg mob yuav ntsib teeb meem ua kom sib haum, haus tshuaj ua ntej cov xwm txheej xav tau kev tawm tsam sai thiab cov kev txav ceev ceev yuav tsum ua nrog qhov tseeb.

Feem ntau cov neeg mob ntshav qab zib siv cov tshuaj ua ib feem ntawm txoj kev kho kom ncaj ncees, yog li nws yog qhov nyuaj heev los txiav txim nws cov hauj lwm zoo. Tab sis hauv Is Taws Nem ntawm cov lus qhia tshwj xeeb thiab cov chaw sib tham, koj tuaj yeem nrhiav ntau cov kev txheeb xyuas txog cov tshuaj no. Feem ntau, lawv muaj qhov zoo.

Kuv tau kuaj tias muaj kev tawm tsam tshuaj insulin. Txhawm rau txhim kho txoj kev zoo, kuv tau siv cov tshuaj siv hauv tsev thiab txawv teb chaws tau ntev, tab sis tsis muaj kev tshwm sim zoo. Tus kws kho mob sau "Trazhent", Kuv haus nws rau ib hlis, ntxiv kuv ua raws kev noj haus nruj. Nyob rau lub sijhawm luv luv no, Kuv poob yuav luag 4.5 kg. Txaus siab heev nrog cov nyhuv. Thaum pib ntawm kev noj tshuaj muaj qhov tshwm sim me me tau hais hauv kev piav qhia ntawm cov ntsiav tshuaj, tab sis lawv dhau sai.

Kuv sawv ntxov pib nrog kev noj tshuaj "Ntshav Qab Zib", thaum yav tsaus ntuj kuv haus "Trazhentu". Qhov ntsuas suab thaj qhia 6-8 mmol / L. Txij li kuv yog tus mob ntshav qab zib nrog kev paub, rau kuv qhov no yog qhov tshwm sim zoo heev. Yog tsis muaj Trazhenta, glycated hemoglobin index tsis poob qis dua 9.3 feem pua, tam sim no nws yog 6.4. Ntxiv rau cov ntshav qab zib, Kuv raug mob los ntawm pyelonephritis, tab sis Trazhenta tsis txhoj puab heev rau lub raum. Txawm hais tias cov tshuaj no muaj qhov siv nyiaj rau cov laus, lawv cov txiaj ntsig tau raws txhua qhov kev cia siab.

Petr Mikhailovich, 65 xyoo

Tus kws kho mob tau hais kom ua "Trazhenta" kom khov thiab hnyav. Lub sijhawm thaum ntxov ntawm kev siv tshuaj, cov kev mob tshwm sim tau nrov heev. Kuv yuav tsum tau hais kom nrhiav kom tau ib qho analog. Yog, thiab kim heev no "Trazhenta".

Tus nqi them nyiaj ntawm kev lag luam hauv chaw muag tshuaj txawv ntawm 1480 txog 1820 rubles rau ntim No. 30. "Trazhenta" tsuas yog muag rau cov tshuaj noj.

Cov pab pawg ntawm DPP-4 inhibitors, uas suav nrog Trazhenta, muaj cov cim tawm los tiv thaiv kab mob thiab kev nyab xeeb. Xws li cov tshuaj lag luam tsis ua rau lub ntsej muag hypoglycemic, tsis txhob txhawb lub cev hnyav thiab tsis muaj qhov tsis zoo ntawm lub raum. Txog tam sim no, pab pawg neeg tshuaj thoob ntiaj teb no suav hais tias yog qhov muaj txiaj ntsig zoo tshaj plaws thiab tau cog lus tias qhov kev tswj hwm ntawm T2DM.