Ethamsylate: cov lus qhia rau kev siv

Ethamsylate yog tus neeg sawv cev hemostatic, tus yam ntxwv ntawm angioprotective thiab proaggregate kev ua. Cov tshuaj ua kom sai rau kev txhim kho cov platelets thiab lawv cov tawm los ntawm cov pob txha pob txha, ua kom lub cev tsis ruaj khov ntawm cov phab ntsa ntawm cov hlab ntsha, kom lawv dhau los ua neeg tsis nkag mus. Nws muaj peev xwm nce platelet adhesion thiab inhibit prostaglandin biosynthesis.

Kev siv ntawm Etamsylate ua kom nrawm nrawm rau kev tsim lub ntsiab lus tseem ceeb thiab txhim kho nws txoj kev thim rov qab, kev xyaum ua yam tsis muaj kev cuam tshuam cov ntsiab lus ntawm fibrinogen hauv cov ntshav thiab prothrombin lub sijhawm. Nws tsis muaj cov khoom hypercoagulant; siv hauv kev siv tshuaj tsis cuam tshuam rau kev tsim cov ntshav txhaws.

Nrog kev tswj hwm (iv), kev ua haujlwm ntawm tus txheej txheem hemostasis tshwm sim tsis pub dhau 5-15 feeb tom qab txhaj, thiab cov txiaj ntsig siab tshaj plaws tau tiav tom qab 1-2 teev. Lub sijhawm ua ntawm 4-6 teev.

Thaum noj cov tshuaj Ethamsylate, cov txiaj ntsig siab tshaj plaws tau sau tseg tom qab 2-4 teev. Kev ua tau zoo ntawm cov tshuaj nquag nyob hauv cov ntshav yog 0.05-0.02 mg / ml. Cov tshuaj tawm hauv cov zis (80%), hauv ib qho me me nrog bile.

Tom qab kawm tiav ntawm kev kho kom zoo, kev ua kom zoo dua li 5-8 hnub, maj mam qaug zog. High efficiency thiab ib tug me me ntawm contraindications ntawm cov tshuaj muab kev zoo xyuas txog Etamsilate los ntawm cov kws kho mob.

Cov tshuaj tsis tau sau tseg rau cov mob pob txha, mob zais thiab cev xeeb tub.

Daim ntawv noj tshuaj:

Ethamsylate muaj nyob rau hauv cov tshuaj rau cov leeg thiab tshuaj leeg, hauv tshuaj thiab ntsiav tshuaj rau menyuam yaus.

Kev Taw Qhia Ethamsilate

Raws li cov lus qhia rau kev siv ntawm Etamsylate, cov tshuaj yog siv rau kev kho mob monotherapy thiab hauv txoj kev kho mob nyuaj rau:

1. Tiv thaiv thiab tiv thaiv capillary los ntshav tawm tsam keeb kwm ntawm kev mob ntshav qab zib,
2. Kev pab cuam phais mob hauv cov kev coj ua otolaryngological (tonsillectomy, pob ntseg me me thiab lwm tus),
3. Kev phais Ophthalmic (tshem tawm cataract, keratoplasty, antiglaucomatous phais),
4. Kho hniav ua haujlwm (tshem tawm ntawm granulomas, hlwv, hniav ntxiv),
5. Txoj haujlwm urological (prostatectomy),
6. Lwm yam, nrog rau kev kho mob poj niam, kev cuam tshuam - tshwj xeeb tshaj yog rau cov kabmob thiab cov nqaij mos uas muaj cov kev ua haujlwm hauv lub cev ntau,
7. Pab kho mob ntsig txog mob ntsws thiab mob hnyuv ntshav,
8. Hemorrhagic diathesis.

Cov lus qhia rau kev siv Etamsylate - ntsiav tshuaj thiab hno

Ethamsilate kev txhaj tshuaj yog muab tshuaj rau txoj leeg khov thiab intramuscularly, hauv kev coj ua ophthalmic - nyob rau hauv daim ntawv ntawm cov tshuaj pleev qhov muag thiab retrobulbar.

Cov qauv muab rau cov laus:

Sab hauv, ib qho tshuaj Ethamsilate rau cov neeg laus yog 0.25-0.5 g, raws li kev qhia, qhov ntau npaum li cas tuaj yeem nce txog 0.75 g, niam txiv zoo - 0.125-0.25 g, yog tias tsim nyog txog 0.375 g.

Cov kev cuam tshuam kev phais - rau kev tiv thaiv ntawm etamsylate, lawv tau txhaj rau hauv / hauv lossis hauv m 1 teev ua ntej kev phais mob hauv qhov ntau npaum li 2-4 ml (1-2 ampoules) lossis sab hauv 2-3 ntsiav tshuaj (0.25 g) 3 teev ua ntej kev phais mob Cov.
Yog tias tsim nyog, txhaj 2-4 ml ntawm cov tshuaj rau hauv lub sijhawm ua haujlwm.

Thaum muaj kev pheej hmoo tom qab los ntshav, 4 rau 6 ml (2-4 ampoules) raug siv rau ib hnub lossis 6 rau 8 ntsiav tshuaj Etamsylate muab rau ib hnub. Qhov muab tau muab faib tusyees ntawm 24 teev.

Thaum muaj xwm ceev: kev txhaj tshuaj sai rau hauv / hauv lossis intramuscularly, thiab tom qab ntawd txhua 4-6 teev nyob rau hauv / hauv, hauv / m lossis sab hauv. Kev pom zoo txhaj tshuaj.

Hauv kev kho mob ntawm metro- thiab menorrhagia, cov lus qhia rau kev siv tshuaj ethamzilate rau kev coj khaub ncaws pom zoo kom haus ib qho 0.5 ntawm qhov ncauj lossis 0.25 g parenterally (bypassing lub plab zom mov) tom qab 6 teev rau 5-10 hnub.

Tom qab rau kev tiv thaiv lub hom phiaj - 0.25 g qhov ncauj 4 zaug nyob rau txhua hnub lossis 0.25 g parenterally 2 zaug nyob rau txhua txhua hnub thaum los ntshav (los ntshav) thiab ob hauv ob peb hlis dhau los.

Hauv kev mob ntshav qab zib myacroangiopathy, Kev txhaj tshuaj Etamsylate raug muab rau hauv m rau 10-14 hnub hauv ib zaug ntawm 0.25-0,5 g 3 zaug hauv ib hnub lossis hauv cov chav kawm ntawm 2-3 lub hlis nrog muab tshuaj ntawm 1-2 ntsiav tshuaj 3 zaug hauv ib hnub.

Nrog hemorrhagic diathesis, txoj kev kho mob muab rau cov kev taw qhia ntawm cov tshuaj hauv cov chav kawm ntawm 1.5 g ib hnub nyob rau hauv kev ncua sij hawm rau 5-14 hnub. Hauv cov mob hnyav, kev kho mob pib nrog kev tswj hwm ntawm niam txiv ntawm 0.25-0.5 g 1-2 zaug hauv ib hnub rau 3-8 hnub, thiab tom qab ntawd ces muab ntawm qhov ncauj.

Hauv kev kho ntawm dysfunctional uterine los ntshav, Ethamsylate yuav tsum noj qhov ncauj ntawm 0.6 grams txhua 6 teev. Lub sijhawm kho yog li 10 hnub. Tom qab ntawd kev saib xyuas txij nkawm ntawm 0.25 g yog tshuaj 4 lub sijhawm ib hnub ncaj qha thaum los ntshav (dhau 2 lub hlis). Niam txiv 0.25 g muab 2 zaug ib hnub.

Hauv ophthalmology, cov tshuaj yog muab tshuaj subconjunctival lossis retrobulbar - ntawm koob ntawm 0.125 g (1 ml ntawm 12,5% kev daws).

Rau cov menyuam yaus:

Thaum lub sijhawm ua haujlwm prophylactically, los ntawm qhov ncauj hauv qhov ntau npaum ntawm 10-12 mg / kg hauv 2 faib cov koob tshuaj rau 3-5 hnub.

Thaum muaj xwm ceev thaum lub sijhawm ua haujlwm - ethamzilate txhaj tshuaj 8-10 mg / kg lub cev hnyav.

Tom qab phais, rau kev tiv thaiv kom tsis txhob los ntshav - sab hauv, ntawm 8 mg / kg.

Nrog hemorrhagic syndrome hauv cov menyuam yaus, Ethamsylate raug muab rau hauv ib koob ntawm 6-8 mg / kg ntawm qhov ncauj, 3 zaug hauv ib hnub. Lub sijhawm ntawm kev kho mob yog 5-14 hnub, yog tias tsim nyog, cov chav kawm raug rov ua dua tom qab 7 hnub.

Cov tshuaj no yog siv rau cov menyuam yaus hnub nyoog dhau 6 xyoo. Tsis txhob muab tshuaj rau hauv lub xub ntiag ntawm hemoblastoses.

Tus kws kho tsiaj:

Ethamsylate tseem tseem siv hauv tsiaj tu tsiaj. Qhov muab tshuaj rau cov miv yog 0.1 ml ib kg ntawm cov tsiaj qhov hnyav, 2 zaug hauv ib hnub (txhaj).

Cov Khoom Tiv Thaiv Ib Leeg Etamsylate

Contraindications ntawm cov tshuaj yog txuam nrog nce thrombosis thiab mob cuam tshuam:

• Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj,
• Mob ntsws ua, thromboembolism, ntshav nce ntxiv,
• Acute daim ntawv ntawm porphyria,
• Hemoblastosis (lymphatic thiab myeloid leukemia, osteosarcoma) hauv cov menyuam yaus.

Xyuam xim nrog los ntshav rau ntawm keeb kwm yav dhau los ntawm kev noj tshuaj ntau dhau ntawm cov tshuaj anticoagulants.

Cov tshuaj tsis sib haum nrog lwm yam tshuaj. Tsis txhob sib xyaw rau hauv tib lub syringe nrog lwm cov tshuaj thiab cov tshuaj.

Sab Tshuaj Etamzilat

• zoo nkaus li tsis xis nyob lossis hlawv hauv hauv siab hauv siab,
• qhov kev xav ntawm hnyav nyob rau hauv lub qhov ntawm lub plab
• mob taub hau thiab kiv taub hau,
• kev nkhaus ntawm cov leeg ntshav ntawm lub ntsej muag
• txo hauv systolic ntshav siab,
• tsis kaj siab zoo li necrosis ntawm daim tawv nqaij (loog), tsim "pob txha caj qaum" los yog qhov tsis meej, tsis meej pem lub ntsab thaum chwv.

Cov npe ntawm Etamsilat, cov npe

Thaum nrhiav kev hloov chaw, thov nco ntsoov tias tsuas yog sau npe tag nrho cov khoom ntawm Etamsilate yog Dicinon. Lwm yam analogues rau cov nyhuv ntawm lub cev:

Ib qho kev hloov pauv ntawm Etamzilat nrog analogues yuav tsum pom zoo nrog kws kho mob! Nws yog ib qho tseem ceeb kom nkag siab tias qhov kev qhia no rau kev siv Etamsylate ntsiav tshuaj thiab kev txhaj tshuaj tsis siv rau cov tshuaj analogues thiab yuav tsum tsis txhob siv cov lus qhia rau kev ua yog tsis muaj kev teem caij thiab kev sab laj ntawm kws kho mob.

Cia rau cov neeg mob
Muab cia rau hauv qhov chaw tsaus tsaus ntawm cov me nyuam ntawm qhov kub tsis tshaj 25 ° C.

Pharmacological kev txiav txim

Hemostatic, angioprotective tus neeg sawv cev.

Nws ua rau ntawm platelet txuas ntawm hemostasis. Nws pab txhawb kev tsim cov platelets thiab kev tso cov platelets los ntawm cov pob txha pob txha, nce lawv cov lej thiab kev ua haujlwm hauv lub cev. Nws nce tus nqi ntawm kev tsim thrombus thawj, uas tej zaum yuav yog vim kev sim tsaj ntawm nqaij ntshiv thromboplastin tsim, thiab ua kom zoo dua thrombus tawm. Nws muaj cov haujlwm antihyaluronidase, inhibits qhov sib cais ntawm mucopolysaccharides ntawm cov vascular phab ntsa thiab stabilizes ascorbic acid, vim tias cov tsis kam ntawm capillaries nce, permeability thiab fragility ntawm microvessels txo. Nws tsis muaj qhov cuam tshuam hypercoagulant, tsis cuam tshuam rau theem ntawm fibrinogen thiab prothrombin lub sijhawm.

Qhov siab tshaj plaws thaum noj ntawm qhov ncauj yog sau tseg tom qab 3 teev. Hauv koob tshuaj ntau npaum li 1-10 mg / kg, qhov hnyav ntawm kev nqis tes ua yog sib npaug rau cov koob tshuaj, nce ntxiv ntawm qhov koob tshuaj ua rau tsuas yog nce me ntsis ntawm kev ua haujlwm. Tom qab ib chav kho mob, cov nyhuv ua mob siab rau 5-8 hnub, maj mam qaug zog.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, nws yuav luag txhua yam nqus tau ntawm txoj hnyuv mus. Qhov siab tshaj plaws nyob rau hauv cov ntshav tau tiav tom qab 3-4 teev. Cov tshuaj kho kom zoo nyob hauv cov ntshav yog 0.05-0.02 mg / ml. Nws tsis muaj zog khi rau cov protein thiab ntshav. Nws yog tusyees faib rau ntau yam plab hnyuv siab raum thiab cov ntaub so ntswg (nyob ntawm seb qhov ntau ntawm lawv cov ntshav). Kwv yees li 72% ntawm cov koob tshuaj txhaj tau tawm hauv thawj 24 teev nrog zis hauv ib qho xwm txheej tsis hloov. Ethamsylate hla kev tso cov nyom ntawm mis thiab nkag mus rau niam mis.

Kev ntsuas rau siv

Kev tiv thaiv thiab tswj cov hemorrhages nyob rau sab saum toj thiab sab hauv capillaries ntawm ntau yam etiologies, tshwj xeeb tshaj yog yog los ntshav los ntawm endothelial puas:

- kev tiv thaiv thiab kev kho mob los ntshav thaum lub sijhawm thiab tom qab phais mob phais mob hauv otolaryngology, kev kho mob poj niam, kev mob plab, hlwv, kev kho hniav, kho qhov muag thiab phais yas,

- kev tiv thaiv thiab kev kho mob ntawm capillary los ntshav ntawm ntau yam etiologies thiab lub zos: hematuria, metrorrhagia, thawj hypermenorrhea, hypermenorrhea rau cov poj niam nrog mob plab, txhaws ntswg, ntshav tawm los.

Tsuas tshuaj thiab tswj hwm

Siv sab hauv tsis hais cov zaub mov noj.

Thaum muaj kev cuam tshuam kev phais mob, cov neeg laus tau txhaj tshuaj 0.5-0.75 g (2-3 ntsiav tshuaj) 3 teev ua ntej kev phais mob, cov menyuam yaus hnub nyoog 12 xyoos tau tshaj tawm raws li 1-12 mg / kg lub cev hnyav (1 / 2-2 ntsiav tshuaj) ib hnub nyob rau hauv 1-2 koob, tsis pub dhau 3-5 hnub ua ntej kev phais mob.

Yog tias muaj kev phom sij tom qab los ntshav, cov neeg laus tau sau tseg 1-2 g (4-8 ntsiav tshuaj), cov menyuam yaus hnub nyoog 12 xyoos tau tshaj tawm 8 mg / kg lub cev hnyav (1-2 ntsiav tshuaj) tusyees (hauv 2-4 koob) thaum thawj hnub tom qab haujlwm.

Yog hais tias hemorrhagic diathesis (thrombocytopathy, Villeurbrand's disease, Wörlhoff's disease), cov neeg laus raug tso cai 1.5 g kev kawm (6 ntsiav tshuaj), cov menyuam muaj hnub nyoog 12 xyoos tau sau tseg 6-8 mg / kg lub cev qhov hnyav ib hnub hauv 3 faib ua ntu zus lub sijhawm rau 5-14 hnub. Lub chav kawm ntawm kev kho mob, yog tias tsim nyog, tuaj yeem rov ua dua tom qab 7 hnub.

Hauv cov kab mob ntshav qab zib microangiopathies (retinopathies nrog hemorrhages), cov neeg laus yog cov tshooj cai ntawm 0.25-0.5 g (1-2 ntsiav tshuaj) 3 zaug hauv ib hnub rau 2-3 lub hlis, cov menyuam muaj hnub nyoog 12 xyoos - 0.25 g (1 ntsiav tshuaj ) 3 zaug ib hnub rau 2-3 lub hlis.

Hauv kev kho mob ntawm metro thiab menorrhagia, 0.75-1 g (3-4 ntsiav tshuaj) tau kho nyob rau hauv ib hnub hauv 2-3 koob, pib txij hnub tim 5 ntawm lub hnub xav txog kev coj khaub ncaws mus txog 5 hnub tom ntej ntawm lub cev ntas. Tsis muaj pov thawj ntawm qhov xav tau los kho qhov tshuaj ntau dua rau cov neeg uas muaj lub siab thiab lub raum ua haujlwm.

Sab sij huam

Los ntawm cov hlab ntsha hauv lub cev: tsis tshua muaj - mob taub hau, kiv taub hau, yaug, txhaws caj npab hauv ob txhais ceg.

Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, mob epigastric.

Los ntawm cov txheej txheem ua pa: bronchospasm.

Ntawm ib feem ntawm kev tiv thaiv kab mob: tsis tshua muaj - kev ua xua tshwm sim, ua npaws, tawm pob ntawm daim tawv nqaij, ib kis ntawm angioedema tau piav qhia.

Los ntawm cov kab ke endocrine: tsis tshua muaj - exacerbation ntawm porphyria.

Los ntawm cov leeg musculoskeletal: tsis tshua muaj - mob nraub qaum.

Tag nrho cov kev mob tshwm sim yog mob me thiab ua rau caij nyoog.

Hauv cov menyuam yaus raug kho nrog etamsylate tiv thaiv los ntshav hauv lymphatic thiab myeloid leukemia, kev tiv thaiv mob leukopenia ntau dua feem ntau tau sau tseg.