Humalog analogues

Hom 1 ntshav qab zib mellitus ib txwm xav tau cov tshuaj insulin, thiab yam ntshav qab zib hom 2 qee zaum xav tau insulin. Yog li no, yuav tsum muaj kev tswj hwm ntxiv ntawm qhov hormone. Ua ntej siv cov tshuaj, ib qho yuav tsum kawm nws cov teebmeem pharmacological, contraindications, muaj kev phom sij, tus nqi, tshuaj xyuas thiab analogues, sab laj tus kws kho mob thiab txiav txim qhov koob.

Humalog yog cov hluavtaws sib piv ntawm cov tib neeg muaj suab thaj-txo cov tshuaj hormones. Nws muaj cov nyhuv hauv lub sijhawm luv luv, tswj cov txheej txheem ntawm cov metabolism hauv qabzib hauv lub cev thiab qib. Nws yuav tsum raug sau tseg tias cov piam thaj tseem ntxiv hauv daim siab thiab cov leeg ua glycogen.

Lub sijhawm ntawm cov tshuaj yog nyob ntawm ntau ntawm ntau yam, suav nrog tus neeg ntawd tus yam ntxwv ntawm tus neeg mob. Piv txwv, hauv tus neeg mob uas muaj ntshav qab zib hom 2, thaum siv cov tshuaj hypoglycemic thiab kev kho tshuaj insulin, kev tswj hwm qib siab ntau dua yog pom. Cov tshuaj tseem tuaj yeem txwv tsis pub muaj cov piam thaj hauv cov ntshav qab zib thaum hmo ntuj so hauv cov neeg mob ntshav qab zib. Hauv qhov no, pathology ntawm lub siab lossis ob lub raum tsis cuam tshuam rau cov metabolism hauv cov tshuaj.

Cov tshuaj Humalog pib hypoglycemic nyhuv tom qab noj tom qab 15 feeb, yog li cov neeg mob ntshav qab zib feem ntau ua rau kev txhaj tshuaj ua ntej noj mov. Tsis zoo li lub cev tib neeg txoj kev loj hlob, cov tshuaj no tsuas kav ntev li 2 mus rau 5 teev, thiab tom qab ntawd 80% ntawm cov tshuaj tso tawm los ntawm lub raum, tshuav 20% - los ntawm lub siab.

Ua tsaug rau cov tshuaj, cov kev hloov pauv zoo tshwm sim:

1. kev ua kom muaj protein ntau zuj zus,
2. ntxiv kom tsawg ntawm cov amino acids,
3. maj mam ua kom tawg ntawm glycogen hloov mus rau hauv qabzib,
4. kev txwv ntawm kev hloov ntawm cov piam thaj los ntawm cov tshuaj protein thiab cov rog.

Nyob ntawm qhov kev saib xyuas ntawm cov tshuaj nquag, Lispro insulin, ob hom tshuaj tso tawm nyob rau hauv lub npe Humalog Mix 25 thiab Humalog Mix 50. Hauv thawj kis, 25% daws ntawm hluavtaws hormone thiab 75% raug ncua ntawm cov tshuaj tiv thaiv muaj, nyob rau hauv rooj plaub thib ob, lawv cov ntsiab lus yog 50% rau 50%. Tshuaj kho mob kuj tseem muaj qee qhov me me ntawm cov khoom siv ntxiv: glycerol, phenol, metacresol, zinc oxide, dibasic sodium phosphate, dej haus, sodium hydroxide 10% lossis hydrochloric acid (daws 10%). Ob qho tshuaj no yog siv rau cov tshuaj insulin-tiv thaiv tsis rau tus mob ntshav qab zib thiab tsis-insulin.

Cov insulins hluavtaws yog tsim nyob rau hauv daim ntawv ntawm kev ncua, uas yog xim dawb. Cov dej nag dawb thiab cov kua translucent saum nws kuj tuaj yeem tsim, nrog kev ntxhov siab, qhov sib xyaw ua kom homogeneous dua.

Humalog Mix 25 thiab Humalog Mix 50 kev ncua yog muaj nyob rau hauv 3 ml cartridges thiab hauv koob txhaj tshuaj.

Cov lus qhia rau kev siv tshuaj

Rau cov tshuaj, ib qho tshwj xeeb Quick Pen syringe cwj mem yog muaj rau kev tswj hwm yooj yim dua. Ua ntej ua ntawv thov nws, koj yuav tsum nyeem phau Ntawv Qhia Cov Lus Qhia Txuas nrog. Qhov insulin daim cartridge yuav tsum tau muab sib dhos ntawm lub xib teg ntawm txhais tes rau qhov kev ncua ntawv kom dhau los ua homogeneous. Thaum kuaj pom qhov txawv ntawm cov khoom txawv txawv hauv nws, cov tshuaj zoo dua tsis siv txhua. Txhawm rau nkag mus rau cov cuab yeej kom raug, koj yuav tsum ua raws qee txoj cai.

Ntxuav koj txhais tes kom huv thiab txiav txim siab qhov chaw txhaj tshuaj. Tom ntej, kho qhov chaw nrog tshuaj tua kab mob. Tshem tawm ntawm txoj hlua tiv thaiv los ntawm rab koob. Tom qab qhov no, koj yuav tsum kho qhov tawv nqaij. Cov kauj ruam tom ntej yog los ntxig cov koob subcutaneously raws li cov lus qhia. Tom qab tshem rab koob, qhov chaw yuav tsum muab nias thiab tsis zaws. Nyob rau theem kawg ntawm cov txheej txheem, cov koob siv tau raug kaw nrog lub hau, thiab tus cwj mem syringe yog kaw nrog lub hau tshwj xeeb.

Cov lus qhia uas xa nrog muaj cov ntaub ntawv tsuas yog kws kho mob tuaj yeem sau ntawv muab tshuaj kom yog thiab tshuaj noj ntawm cov tshuaj insulin, muab cov ntsiab lus ntawm cov suab thaj hauv cov ntshav ntawm tus neeg mob. Tom qab kev yuav khoom ntawm Humalog, cov lus qhia rau kev siv yuav tsum tau ua tib zoo kawm. Koj tseem tuaj yeem pom cov cai tswjfwm rau kev tswjfwm hauv cov tshuaj hauv nws:

• hluavtaws cov tshuaj tua kab mob tsuas yog tswj ua subcutaneously, nws yog txwv tsis pub nkag rau hauv nws cov leeg,
• qhov kub ntawm cov tshuaj ntawm lub sijhawm ntawm kev tswj hwm yuav tsum tsis txhob qis dua chav sov,
• kev txhaj tshuaj yog tsim nyob hauv tus ncej, pob tw, xub pwg lossis lub plab,
• lwm qhov chaw txhaj tshuaj
• thaum tswj hwm cov tshuaj, koj yuav tsum xyuas kom meej tias lub koob tsis tshwm hauv qhov lumen ntawm cov hlab ntsha
• tom qab kev ua haujlwm ntawm cov tshuaj insulin, qhov chaw txhaj tshuaj tsis tuaj yeem raug muab tua pov tseg.

Ua ntej siv, sib tov yuav tsum muab chais.

Lub txee lub neej ntawm cov tshuaj yog peb xyoos. Thaum cov lus no xaus, nws siv tau txwv. Cov tshuaj yuav cia nyob hauv qhov ntau ntawm 2 txog 8 degrees tsis muaj hnub ci.

Cov tshuaj uas siv tau yog khaws cia ntawm qhov kub uas tsis pub tshaj 30 degrees txog li 28 hnub.

Analogs hauv kev muaj pes tsawg leeg thiab qhia txog kev siv

Cov npe saum toj no ntawm cov yeeb tshuaj analogues, uas qhia Qhov ntsuas ntawm Humalogue, yog qhov tsim nyog tshaj plaws vim tias lawv muaj tib cov tshuaj sib luag thiab sib luag ua ke raws li kev taw qhia rau kev siv

Analogs los ntawm qhov taw qhia thiab cov qauv ntawm kev siv

Sib txawv muaj pes tsawg leeg, tuaj yeem ua ke nyob rau hauv kev taw qhia thiab cov qauv ntawm daim ntawv thov

Yuav ua li cas thiaj nrhiav tau qhov pheej yig tshuaj ntawm cov tshuaj kim?

Txhawm rau kom pom qhov pheej yig cov khoom sib piv rau cov tshuaj, cov dav dav lossis cov lus sau, ua ntej txhua yam peb pom zoo kom them sai sai rau qhov muaj pes tsawg leeg, uas yog rau tib cov tshuaj nquag thiab qhia tau rau kev siv. Cov tshuaj sib xyaw zoo ib yam ntawm cov tshuaj yuav qhia tau tias cov tshuaj cuam tshuam nrog cov tshuaj, kws tshuaj sib npaug lossis chaw muag tshuaj.Txawm li cas los xij, tsis txhob hnov ​​qab txog qhov ua tsis muaj zog ntawm cov tshuaj uas zoo sib xws, uas tuaj yeem cuam tshuam kev nyab xeeb thiab ua haujlwm. Tsis txhob hnov ​​qab txog cov lus qhia ntawm cov kws kho mob, kev noj tshuaj rau nws tus kheej tuaj yeem tsim kev puas tsuaj rau koj kev noj qab haus huv, yog li nco ntsoov sab laj nrog koj tus kws kho mob ua ntej siv cov tshuaj.

Kev qhia ua ntu neeg

Daim ntawv noj tshuaj:

subcutaneous kev ncua

Pharmacological kev txiav txim:

Kev sib xyaw ntawm lyspro insulin - kev ua yeeb yam sai sai thiab kev tiv thaiv tshuaj tiv thaiv ntawm lyspro insulin - nruab nrab ua yeeb yam insulin. Lyspro insulin yog qhov tso tawm DNA ntawm tib neeg cov tshuaj insulin; nws txawv ntawm nws los ntawm kev rov qab los ntawm proline thiab lysine amino acid seem ntawm txoj haujlwm 28 thiab 29 ntawm cov kab insulin B. Regulates glucose metabolism, muaj cov nyhuv anabolic. Hauv cov leeg nqaij thiab lwm cov nqaij (muaj qhov tsis suav ntawm lub hlwb) nws ua kom sai ntawm kev hloov pauv ntawm cov piam thaj thiab amino acids mus rau hauv lub cell, txhawb txoj kev tsim cov glycogen los ntawm cov piam thaj hauv lub siab, inhibits gluconeogenesis thiab txhawb kev hloov pauv ntawm cov piam thaj mus rau cov rog. Equimolar rau tib neeg cov tshuaj insulin. Piv nrog tib neeg cov tshuaj insulin, nws muaj qhov tshwm sim ntawm kev pib sai dua, kev pib ua tiav ntawm qhov siab kawg thiab lub sijhawm luv dua ntawm kev ua haujlwm hypoglycemic (txog 5 teev). Kev pib sai ntawm kev nqis tes ua (15 feeb tom qab kev tswj hwm) cuam tshuam nrog kev nqus siab thiab tso cai rau nws ua sai sai ua ntej noj mov (15 feeb) - tib neeg cov tshuaj insulin raug tswj hauv 30 feeb. Kev xaiv ntawm qhov chaw txhaj tshuaj thiab lwm yam tuaj yeem cuam tshuam tus nqi ntawm kev nqus thiab pib ntawm nws cov kev ua. Qhov siab tshaj plaws tau pom ntawm 0.5 thiab 2.5 teev, lub sijhawm ua ntawm 3-4 teev.

Kev Taw Qhia:

Hom 1 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog nrog kev tsis nkag siab ntawm lwm cov insulins, postprandial hyperglycemia uas tsis tuaj yeem kho los ntawm lwm cov insulins: mob subcutaneous insulin tsis kam (nrawm hauv zos kev cuam tshuam ntawm insulin). Hom 2 mob ntshav qab zib mellitus - nyob rau hauv kis ntawm tsis kam mus rau qhov ncauj hypoglycemic tshuaj, nyob rau hauv kev ua txhaum ntawm kev nqus ntawm lwm cov insulins, thaum lub sijhawm ua haujlwm, cov kabmob sib kis.

Cov Tshuaj Tiv Thaiv:

Kev ua haujlwm tsis txaus ntseeg, kev ua ntshav qab zib, insulinoma.

Phiv los sis:

Kev tsis haum tshuaj (urticaria, angioedema - ua npaws, ua tsis taus pa, ntshav tsawg), lipodystrophy, ua rau muaj qhov tsis zoo ntawm lub sijhawm (feem ntau hauv cov neeg mob uas tsis tau txais insulin yav dhau los), hypoglycemia, hypoglycemic com. Cov tsos mob: tsaug zog, tawm hws, tawm hws, tawm hws, tsis pom kev, tachycardia, tshee tshee, tshaib plab, ntxhov siab, mob plab nyob rau hauv lub qhov ncauj, pallor ntawm daim tawv nqaij, mob taub hau, tshee tshee, ntuav, tsaug zog, pw tsaug zog, ntshai, ntxhov siab, chim siab, txawv txav, qhov tsis paub tseeb txog kev txav chaw, tsis hnov ​​lus thiab pom lub zeem muag, tsis meej pem, hypoglycemic coma, nriaj. Kev Kho Mob: yog tias tus neeg mob nco qab, dextrose raug kho qhov ncauj, s / c, iv lossis iv txhaj tshuaj glucagon lossis iv hypertonic dextrose tov. Nrog rau kev txhim kho lub ntsej muag tsis nco qab, 20-40 ml (txog 100 ml) ntawm 40% dextrose tov yog txhaj iv rau hauv qhov dej kom txog thaum tus neeg mob tawm ntawm lub cev tsis nco qab.

Muab thiab kev coj:

Cov koob tshuaj tau txiav txim siab ib tus zuj zus nyob ntawm theem ntawm glycemia. Kev sib xyaw 25% insulin lispro thiab 75% kev tiv thaiv tshuaj tiv thaiv yuav tsum tau tsuas yog muab s / c, feem ntau 15 feeb ua ntej noj mov. Yog tias tsim nyog, koj tuaj yeem nkag mus nrog kev siv tshuaj insulin kom ntev los yog nrog sulfonylureas rau kev tswj hwm qhov ncauj. Kev txhaj tshuaj yuav tsum tau ua s / c hauv lub xub pwg, lub duav, lub duav lossis lub plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom qhov chaw qub siv tsis ntau tshaj 1 zaug hauv ib hlis. Nrog s / c tswj hwm, kev saib xyuas yuav tsum tau ua kom tsis txhob nkag rau cov ntshav ntshav.Hauv cov neeg mob lub raum thiab / lossis daim siab ua haujlwm, lub siab ntawm cov ntshav insulin nce ntxiv, thiab qhov xav tau nws tuaj yeem txo qis, uas yuav tsum tau ceev faj soj ntsuam ntawm theem ntawm glycemia thiab koob tshuaj kho mob ntawm insulin.

Cov lus qhia tshwj xeeb:

Cov kev ntawm cov thawj coj tswj hwm rau daim ntawv ntau npaum siv yuav tsum tau nruj siv. Thaum hloov cov neeg mob los ntawm kev ua yeeb yam sai sai ntawm cov tsiaj keeb kwm rau insulin lispro, yuav tsum tau txhaj koob tshuaj. Kev hloov chaw ntawm cov neeg mob tau txais cov tshuaj insulin nyob rau hauv ib hnub ntau dua 100 units los ntawm ib hom tshuaj insulin rau lwm tus yog pom zoo kom nqa tawm hauv tsev kho mob. Qhov xav tau ntawm cov tshuaj insulin tuaj yeem nce ntxiv thaum muaj kab mob kis, nrog kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov khoom noj carbohydrates hauv zaub mov, thaum ntxiv kev noj tshuaj ntxiv nrog hyperglycemic kev ua si (cov thyroid hormones, GCS, qhov ncauj tiv thaiv kab mob, thiazide diuretics). Qhov xav tau ntawm cov tshuaj insulin tuaj yeem txo nrog lub raum thiab / lossis lub siab ua haujlwm, nrog qhov txo qis hauv cov khoom noj hauv cov zaub mov, nrog kev tawm dag zog lub cev, thaum ntxiv kev noj tshuaj nrog hypoglycemic kev ua si (MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides). Kev ntsuam xyuas kev txhim kho hypoglycemia tuaj yeem cuam tshuam cov peev xwm ntawm cov neeg mob koom rau hauv kev tsav tsheb, nrog rau kev saib xyuas cov tshuab thiab tshuab. Cov neeg mob ntshav qab zib tuaj yeem nres cov ntshav qabzib uas tau txais los ntawm lawv los ntawm kev noj cov piam thaj lossis zaub mov ntau hauv carbohydrates (Nws raug nquahu kom koj ib txwm muaj tsawg kawg 20 g suab thaj nrog koj). Nws yog ib qho tsim nyog yuav tsum tau qhia rau tus kws kho mob uas tau tuaj kawm txog qhov hloov pauv hypoglycemia txhawm rau daws qhov teeb meem ntawm qhov xav tau ntawm kev kho mob kho. Qhov xav tau rau cov tshuaj insulin feem ntau poob qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce hauv qib thib ob txog rau qib thib peb. Thaum yug menyuam thiab tam sim ntawd tom qab lawv, xav tau cov tshuaj insulin tuaj yeem txo qis.

Daim ntawv tso tawm

• Txoj kev daws teeb meem tsis muaj kob, muaj pob tshab hauv 3 ml cartridges hauv cov hlwv ntim rau hauv pob ntawv cardboard. 15.
• Daim cartridge rau hauv QuickPen syringe cwj mem (5) yog nyob hauv lub thawv ntawv thawv.
• Cov tshuaj Humulin Mix 50 thiab Humalog Mix 25 kuj tseem muaj. Insulin Humalog Mix yog sib xyaw kom muaj vaj huam sib luag ntawm Lizpro ua yeeb yam luv luv insulin thiab Lizpro insulin ncua nrog ncua ntev.

Cov Tshuaj Hauv Tshuaj

Humalog Mix 50 yog ib qho kev sib xyaw ua ke uas muaj 50% kev daws teeb meem ntawm lispro insulin (ib qho kev sib piv ntawm tib neeg cov tshuaj insulin) thiab 50% kev tiv thaiv kev ncua ntawm lispro insulin (qhov nruab nrab nruab nrab ntawm tib neeg insulin analog).

Cov cuab yeej tseem ceeb ntawm cov tshuaj yog cov kev cai ntawm cov metabolism hauv cov piam thaj. Nws kuj muaj cov teebmeem tawm tsam catabolic thiab anabolic rau ntau cov ntaub so ntswg ntawm lub cev. Hauv cov leeg nqaij ua raws li cov neeg ntawm Humalog Mix 50, cov ntsiab lus ntawm fatty acids, glycerol thiab glycogen nce, cov synthesis protein tau txhim kho, thiab kev noj ntawm cov amino acids yog nce. Qhov no txo ​​cov glycogenolysis, gluconeogenesis, lipolysis, ketogenesis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Nws tau tsim tsa hais tias insulin lyspro muaj qhov sib txawv ntawm tib neeg cov insulin, tab sis nws cov nyhuv loj hlob sai dua thiab siv sijhawm tsawg dua.

Tom qab kev tswj hwm nyob rau hauv daim tawv nqaij, qhov pib sai ntawm lyspro insulin kev txiav txim siab thiab qhov pib thaum ntxov ntawm nws cov haujlwm siab tshaj plaws tau sau tseg. Humalog Mix 50 pib kwv yees li ntawm 15 feeb tom qab txhaj tshuaj, yog li nws tuaj yeem siv txoj cai ua ntej noj mov (hauv 0-15 feeb), tsis zoo li cov neeg insulin zoo tib yam.

Kev txiav txim ntawm profile ntawm insulin lysproprotamine zoo ib yam li cov yeeb yam kev sib piv ntawm cov insulin isofan uas ib txwm muaj ntev li 15 teev.

Cov Tshuaj Pharmacokinetics

Lub pharmacokinetics ntawm Humalog Mix 50 yog txiav txim siab los ntawm cov khoom ntiag tug pharmacokinetic ntawm nws ob yam kev ua haujlwm.

Cov qib ntawm kev nqus thiab pib ntawm kev ua yeeb tshuaj yog nyob ntawm qhov chaw tswj hwm ntawm lub sijhawm (qog, hauv plab, pob tw) thiab nws cov koob tshuaj, nrog rau kev ua si ntawm tus neeg mob, nws lub cev kub thiab tso ntshav tawm.

Lyspro insulin tom qab kev tswj hwm kab mob hauv qab yog nqus tau sai. Qhov siab tshaj plaws hauv cov ntshav nce mus txog hauv 30-70 feeb.

Cov chaw muag tshuaj ntawm lysproprotamine insulin zoo ib yam li cov isofan insulin (nruab nrab insulin).

Hauv lub raum thiab hepatic tsis txaus, lyspro insulin yog nqus sai dua soluble tib neeg cov kua dej.

Cov Yuav Tsum Muaj

• qog ntshav,
• hnub nyoog txog 18 xyoo
• Ua kom lub ntsej muag haum rau ib qho tivthaiv ntawm Humalog Mix 50.

• raum / nplooj siab tsis ua haujlwm,
• kev xav dhau ntawm lub siab, ua kom lub cev ua si ntau dua, lossis kev hloov pauv ntawm lub cev ib txwm muaj lawm (yuav tsum tau txhaj tshuaj insulin ntau npaum li cas),
• lub caij nyoog ntev ntawm mob ntshav qab zib mellitus, mob ntshav qab zib neuropathy, lossis kev siv cov beta-blockers (ib qho kev hloov pauv lossis txo qis ntawm cov tsos mob ua ntej kwv yees hypoglycemia),
• cev xeeb tub thiab lub sijhawm pub mis.

Humalog Mix 50, cov lus qhia rau kev siv: hom thiab siv ntau npaum li cas

Humalog Mix 50 npaj rau kev tswj hwm subcutaneous nkaus xwb. Koj tuaj yeem nkag mus rau nws tam sim ntawd ua ntej noj mov lossis tom qab noj mov. Cov koob tshuaj tau txiav txim los ntawm tus kws kho mob cais ib tus zuj zus rau txhua tus neeg mob, raws theem ntawm cov piam thaj hauv cov ntshav.

Koj tuaj yeem nkag mus rau cov tshuaj hauv plab, ncej, xub pwg lossis pob tw. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom, nyob rau tib qhov chaw, qhov kev ncua yog, yog tias ua tau, tswj tsis pub ntau tshaj ib hlis ib zaug.

Thaum qhia Humalog Mix 50, yuav tsum tau saib xyuas kom tsis txhob raug ncua kev nkag mus hauv lub lumen ntawm cov hlab ntshav. Tsis tas yuav zaws qhov chaw txhaj tshuaj tom qab koj txhaj tas.

Kev siv cov tshuaj nyob rau hauv daim cartridges

Cov kev cai tswjfwm rau kev txhim kho daim cartridge nyob rau hauv cov khoom siv rau kev tswj hwm cov tshuaj thiab cov lus pom zoo rau txuas lub koob rau nws ua ntej kev tswj hwm tau piav qhia nyob rau hauv cov lus qhia ntawm lub tuam txhab tsim cov cuab yeej rau kev siv tshuaj insulin. Nws yog ib qho tseem ceeb kom nruj me ntsis ua raws cov lus qhia.

Ua ntej kev tswj hwm, cov tshuaj yuav tsum tau ua kom sov nyob hauv chav sov. Tam sim ua ntej txhaj tshuaj, daim laub yuav tsum tau muab rhais 10 zaug nruab nrab ntawm xib teg ntawm txhais tes thiab tshee 10 zaug, tig mus rau 180 °, kom cov insulin rov qab siv dua, i.e., nws yuav siv daim ntawv homogeneous turbid kua. Koj tsis tas yuav co lub pob laub kom zoo, vim tias qhov no ua npuas ncauj yuav tsim, uas ua rau nws nyuaj teeb tsa koob tshuaj kom raug. Txhawm rau kom yooj yim sib xyaw ntawm cov tshuaj, ib lub khob pob me me tau muab hauv sab hauv lub taub hau.

Yog tias tom qab nplawm qhov kev ncua ntawv tsis tau txais qhov tsis sib thooj (cov plaub ya ri pom), nws siv tsis tau!

Cov kev cai rau kev nthuav qhia ntawm ib koob tshuaj ntawm Humalog Mix 50:

1. Ntxuav tes.
2. Xaiv qhov chaw txhaj tshuaj thiab npaj cov tawv nqaij, ua raws li cov lus pom zoo los ntawm kws kho mob.
3. Tshem lub hau tiv thaiv sab nraud ntawm rab koob.
4. Kho cov tawv nqaij los ntawm kev khaws nws hauv daim me me.
5. Tso cov koob txhaj tshuaj rau hauv qab daim tawv nqaij tso rau hauv cov quav ntim thiab ua kev txhaj tshuaj, ua raws cov lus qhia rau kev siv rab koob xaum xim.
6. Txhawm rau tshem tawm rab koob thiab nrog lub paj rwb so hauv qab, maj mam nyem qhov chaw txhaj tshuaj rau ob peb feeb. Tsis txhob txhuam thaj tsam txhaj tshuaj.
7. Tshem cov koob siv lub hau npog sab nraud pov tseg thiab pov tseg.
8. Tso lub hau rau ntawm tus cwj mem xaum qhuav.

Kev siv cov tshuaj Humalog 50 hauv cov cwj mem ceev ceev

Cov Cwj mem ceev ceev yog siv tshwj xeeb tsim los tswj cov tshuaj insulin (lub npe hu ua insulin cwj mem). Nws muaj 3 ml ntawm cov tshuaj (300 IU), tso cai rau koj nkag los ntawm 1 mus rau 60 units ntawm cov tshuaj insulin rau ib qhov kev txhaj tshuaj, thiab cov koob tshuaj tuaj yeem tsim nrog qhov tseeb ntawm ib chav.

Cov xim xiav ntawm QuickPen koob txhaj tshuaj lub cev qhia tias nws yog npaj rau siv nrog cov khoom lag luam Humalog.Qhov xim ntawm lub pob txhaj tshuaj ntawm lub koob txhaj tshuaj txuam nrog cov xim ntawm txoj hlua xim ntawm daim ntawv lo ntawm daim duab xaum thiab yog nyob ntawm hom insulin.

Lub QuickPen Syringe Cwj mem tau pom zoo rau kev siv nrog cov koob tsim nyog tsim los ntawm Becton, Dickinson thiab Tuam Txhab (BD).

Txhua rab koob xwj yog tsim rau ib leeg siv. Tsis txhob kis nws rau lwm tus, vim tias qhov no muaj kev pheej hmoo kis tus mob kis tau yooj yim. Rau txhua qhov kev txhaj tshuaj, koj yuav tsum tau siv lub koob tshiab thiab nco ntsoov tias nws tau txuas rau ntawm tus tes tsho txhaj tshuaj ua ntej ntxig.

Nws raug txwv tsis pub siv cov xaum xaum yog tias ib qho ntawm nws qhov chaw tau tawg lossis puas. Nws raug nquahu tias cov neeg mob yeej ib txwm muaj cov phoo tshwj tseg nrog lawv thaum poob lossis tawg.

Humalog Mix 50 hauv QuickPen koob txhaj tshuaj tsis pom zoo rau kev siv ywj pheej los ntawm cov neeg mob uas tsis pom kev zoo.

Cov lus pom zoo npaj rau kev txhaj tshuaj:

1. Ua tib zoo ua raws li txoj cai ntawm kev siv tshuaj tua kab mob thiab tshuaj asepsis pom zoo los ntawm koj tus kws kho mob.
2. Ntxuav tes.
3. Xaiv qhov chaw rau kev txhaj tshuaj, so ntawm daim tawv nqaij.

Cov lus qhia rau kev npaj QuickPen Syringe Cwj mem thiab cov lus qhia ntawm Humalog Mix 50:

1. Rub tawm lub hau ntawm cov tes muag phwj. Tsis txhob tig lub hau, tsis txhob tshem daim ntawv lo ntawm daim phus. Nco ntsoov tias hom insulin thiab qhov tseeb ntawm nws lub neej kev ua haujlwm. Txheeb xyuas cov tsos ntawm kev ncua.
2. Siv ib rab koob tshiab. Tshem daim ntawv nplaum ntawm lub hau dhau. So cov roj hmab disc ntawm qhov kawg ntawm daim cartridge nrog lub paj rwb pas rwb thaiv dej noo nrog dej cawv. Muab rab koob tso rau hauv lub hau ntawm daim duab syringe ncaj qha raws txoj kab axis thiab ntsia hlau nws kom txog thaum nws txuas tag nrho.
3. Tshem lub hau tawm ntawm rab koob (tsis txhob muab pov tseg). Tom qab ntawd tshem lub hau ntawm sab hauv (nws tuaj yeem muab pov tseg).
4. Khij cov koob txhaj tshuaj rau cov tshuaj insulin (qhov tshwm sim ntawm kev ua tsis ncaj ntawm cov tshuaj). Qhov no yuav tsum tau ua txhua zaus ua ntej txhaj tshuaj, kom paub tseeb tias koob txhaj tshuaj yog npaj rau qhov kev qhia ntawm cov koob xav tau, txwv tsis pub koj tuaj yeem nkag rau qhov tshuaj me me lossis ntau dhau.
5. Kho cov tawv nqaij los ntawm rub thiab sau nws mus rau hauv daim ntau quav. Muab ib rab koob tso rau hauv qab daim tawv nqaij raws li kws kho mob pom zoo. Tig lub koob tshuaj khawm mus rau qhov yuav tsum tau muaj ntawm cov kab mob insulin. Tuav tawm khawm khov kho nrog tus ntiv tes xoo ntawm txoj kab ncaj nraim. Txhawm rau nkag mus rau qhov koob tshuaj, tuav lub pob thiab maj mam suav rau 5.
6. Tshem tawm rab koob thiab maj mam nias qhov chaw txhaj tshuaj nrog tus pas nqus dej txhuam rau ob peb feeb tsis xaum nws. Lub xub ntiag ntawm kev poob ntawm cov tshuaj ntawm qhov quav ntawm rab koob yog qhov tshwm sim uas tsis muaj feem cuam tshuam rau koob tshuaj. Yog tias qhov kev tshem tawm plooj tawm ntawm rab koob, feem ntau yuav ua rau tus neeg mob tsis tuav rab koob nyob hauv qab daim tawv nqaij rau lub sijhawm txaus tsim nyog rau kev tswj hwm tag nrho ntawm cov tshuaj.
7. Txuas lub hau sab nraud rau lub koob. Tshem tawm nws ntawm xaum xaum xaum kom tiv thaiv huab cua npuas los ntawm nkag mus rau hauv daim cartridge.

Txawm hais tias cov lej nyob rau hauv lub ntsuas qhov rais luam tawm nyob rau hauv daim ntawv ntawm tus xov tooj, khib - nyob rau hauv daim ntawv ntawm cov kab ncaj nruab nrab ntawm txawm cov zauv.

Yog tias koj yuav tsum tau nkag rau lub koob tshuaj nyob rau hauv ntau dhau ntawm cov lej ntawm cov tshuaj insulin uas nyob hauv lub taub hau, koj tuaj yeem nkag mus rau cov tshuaj seem thiab tom qab ntawd siv tus cwj mem tshiab lossis tam sim ntawd siv tus cwj mem tshiab.

Tsis txhob sim hloov cov tshuaj ntawm cov tshuaj insulin thaum txhaj tshuaj.

Cov ntaub ntawv tseem ceeb! Lub tes tsho xaum tsis tso cai rau koj los teem lub koob tshuaj ntau dhau ntawm cov chav nyob uas tau nyob hauv daim cartridge. Thaum muaj mob uas tus neeg mob tsis paub tseeb tias nws tau muab tshuaj rau tag nrho, ib qho ntxiv yuav tsum tsis txhob muab.

Cov nta ntawm kev khaws thiab pov tseg ntawm cov xaum xaum qhuav:

• tsis txhob siv cov xaum xaum yog tias nws tau khaws cia sab nraum lub tub yees rau ntau tshaj li lub sijhawm teev tseg hauv cov lus qhia,
• tsis txhob tso cov xaum xaum nrog cov koob txuas (qhov tshuaj yuav xau lossis qhuav hauv rab koob, ua rau nws txhaws, pa npuas hauv lub laub yuav tsim tau),,
• Cov xaum uas tsis siv lawm yuav tsum tau muab cia rau hauv tub yees rau ntawm qhov kub li 2–8 ° C. Koj siv tsis tau cov tshuaj yog tias nws khov,
• koob txhaj tshuaj siv tam sim no yuav tsum khaws cia hauv chav sov (tsis pub tshaj 30 ° C), nyob deb ntawm tshav ntuj thiab tshav kub,
• siv koob yuav tsum tau muab pov tseg rau hauv cov chaw xauv khoom, muaj kev tiv thaiv los ntawm kev hno,
• lub koob ntim puv ntim yuav tsum tsis txhob siv tas,
• siv koob txhaj tshuaj (tsis muaj koob) yuav tsum tau muab pov tseg raws li cov lus qhia ntawm koj tus kws kho mob thiab cov cai hauv zos rau kev pov tseg cov khoom kho mob.

Sab sij huam

Cov kev mob tshwm sim feem ntau pom nrog txhua hom tshuaj insulin yog hypoglycemia. Hauv cov xwm txheej hnyav, nws tuaj yeem ua rau tsis nco qab, hauv qee kis tshwj xeeb - ua rau ploj tuag.

Qee zaum cov kev fab tshuaj hauv zos tshwm sim: liab, khaus, lossis o ntawm thaj chaw txhaj tshuaj. Raws li txoj cai, cov xwm txheej no dhau mus ntawm nws tus kheej hauv ob peb hnub / lub lis piam. Hauv cov tib neeg mob, lawv tsis cuam tshuam nrog kev siv cov tshuaj insulin, tab sis raug mob, piv txwv li, los ntawm kev siv tshuaj tsis raug cai los yog tawv nqaij tom qab siv tshuaj ntxuav.

Cov tshuaj Insulin tsis tshua muaj mob ua rau lub cev tsis haum tshuaj, tab sis lawv yuav ua rau hnyav dua. Cov tsos mob hauv qab no tuaj yeem tshwm sim: ua pa luv, ua pa luv, ntshav tawm ntshav tsawg, tachycardia, nce tawm hws, dav dav pruritus. Yog tias muaj qhov ua txhaum fab hnyav, yuav tsum tau siv tshuaj los kho mob sai. Cov neeg mob zoo li no yuav xav tau kev kho kom tsis muaj zog lossis hloov pauv cov kua dej.

Nrog kev kho mob ntev, lipodystrophy yuav pib txhim kho ntawm qhov chaw txhaj tshuaj.

Cov teeb meem sib cais ntawm kev txhim kho ntawm edema tau paub, feem ntau nrog kev ceev ceev ntawm cov ntshav qabzib feem ntau tiv thaiv keeb kwm ntawm kev siv tshuaj insulin ntau dua nrog kev pib tsis txaus siab glycemic tswj.

Noj ntau dhau

Nrog rau kev noj tshuaj ntau dhau ntawm cov tshuaj insulin, cov ntshav qog ntshav qab zib nce zuj zus, nrog rau cov tawv nqaij daj ntseg, nce tawm hws, dias nkees, mob taub hau, tsis meej pem, tshee tshee, tachycardia, thiab ntuav. Hauv qee qhov xwm txheej (piv txwv, nyob rau hauv qhov kev soj ntsuam nruj saib xyuas ntshav qab zib mellitus lossis nrog lub sijhawm ntev ntawm ntshav qab zib mellitus), cov tsos mob ua ntej ntawm hypoglycemia yuav hloov.

Hypoglycemia feem ntau yog nres los ntawm kev noj cov piam thaj lossis qabzib. Raws li cov tshuaj ntsuas, tshuaj insulin, kev noj haus thiab / lossis kev ua haujlwm lub cev yog kho.

Cov ntshav qog ntshav ntshav qis yog kho los ntawm kev siv tshuaj intramuscular lossis subcutaneous ntawm glucagon, tom qab ntawd tus neeg mob tau pom zoo rau qhov ncauj kev noj haus.

Kev mob ntshav khov ntau heev tuaj yeem ua rau lub paj hlwb tsis meej pem, mob nriaj, rov qab. Cov neeg mob zoo li no yog kws kho mob ntawm cov ntshav qab zib lossis kev tswj hwm ntawm glucagon los yog kev tso ntshav dej qab zib ntawm cov tshuaj muaj qabzib (dextrose). Txhawm rau tiv thaiv qhov kev rov txhim kho ntawm hypoglycemia, tom qab rov qab nco qab, tus neeg mob yuav tsum noj zaubmov kom muaj protein ntau. Tus neeg mob yuav tsum yog nyob ntawm kev saib xyuas los ntawm kws kho mob.

Cov lus qhia tshwj xeeb

Thaum hloov mus rau tus neeg mob mus rau lwm hom tshuaj insulin lossis insulin cov khoom nrog cov npe txawv, yuav tsum tau ua tib zoo saib xyuas kev kho mob. Yog tias koj hloov lub hom (cov chaw tsim khoom), hom (tsiaj insulin, tib neeg lossis tib neeg analog), hom (solulin insulin, isophan insulin, thiab lwm yam) thiab / lossis cov qauv kev npaj (DNA recombinant insulin lossis tsiaj insulin), yuav tsum tau kho kom raug koob tshuaj.

Thaum hloov mus rau tus neeg mob los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg los ntawm insulin, yuav tsum tau txhaj tshuaj ntau dua, ntxiv mus, thawj zaug kev siv tshuaj lossis maj mam dhau ob peb lub lis piam / hli ntawm txoj kev kho.

Hypo-thiab hyperglycemic tej yam kev mob yuav tsum raug kho, txwv tsis pub lawv tuaj yeem ua rau poob kev nco qab, tsis nco qab thiab tuag taus.Nws yuav tsum tau yug los rau hauv lub siab tias cov tsos mob ntawm cov xwm txheej ua ntej ntawm tus mob ntshav qab zib tuaj yeem hloov pauv, lawv qhov hnyav yuav poob qis nrog lub caij nyoog ntev ntawm mob ntshav qab zib mellitus lossis ntshav qab zib neuropathy, nrog rau kev siv cov beta-blockers.

Kev noj tshuaj tsis txaus thiab tshem tawm ntawm Humalog Mix 50, tshwj xeeb tshaj yog muaj ntshav qab zib hom 1, tuaj yeem ua rau ketoacidosis mob ntshav qab zib thiab ntshav qab zib - mob uas ua rau muaj kev hem thawj rau tus neeg mob lub neej.

Muaj qee yam mob thiab kev ntxhov siab, kev xav tau cov tshuaj insulin tuaj yeem nce ntxiv.

Humalog Mix 50 koob tshuaj yuav tau hloov pauv yog muaj pauv hauv kev noj zaub mov zoo lossis ua si lub cev. Lub cev ua si ntau dua qee zaum ua rau muaj kev pheej hmoo ntawm lub qog ntshav qab zib.

Daim cartridges nrog cov tshuaj yuav tsum tau siv nrog cov phwj sam koob uas muaj qhov cim CE.

Txhawm rau txhawm rau txhawm rau tiv thaiv kev kis tus kab mob sib kis tau, tsuas yog ib tus neeg mob yuav tsum siv txhua daim cartridge lossis rab koob xaum, txawm tias tom qab hloov rab koob.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Nrog rau kev txhim kho hypoglycemia, qhov kev txo qis ntawm qhov kev hloov pauv thiab kev mloog zoo yog qhov ua tau, uas ua rau muaj kev pheej hmoo ntawm kev raug mob thaum ua cov haujlwm phom sij, nrog rau kev tsav tsheb thiab ua haujlwm nrog cov txheej txheem nyuaj. Hauv qhov no, kev ceev faj yuav tsum tau siv, tshwj xeeb tshaj yog nyob rau cov neeg mob uas cov tsos mob ua ntej ntawm lub qog ntshav qab zib tsis tuaj lossis mob me. Xws li kev txhim kho ntshav nce siab ntau dhau, qhov ua tau ntawm kev nqis tes ua haujlwm nrog rau qhov xwm txheej tsis zoo yuav tsum raug ntsuas.

Cev xeeb tub thiab lactation

Cov kev tshawb fawb muaj txhij txhua thiab nruj me ntsis hauv cov poj niam cev xeeb tub tsis tau ua. Hauv kev sim tsiaj, kev muaj peev xwm tsis taus thiab qhov tsis zoo ntawm cov tshuaj ntawm tus me nyuam hauv plab tsis tau kuaj pom. Txawm li cas los xij, nws paub tias cov txiaj ntsig tau txais los ntawm kev tshawb nrhiav ntawm cov nyhuv ntawm cov tshuaj rau tsiaj kev ua me nyuam tsiaj tsis yog ib txwm piv nrog cov txiaj ntsig ntawm cov tshuaj ntawm tib neeg lub cev. Hauv qhov no, thaum cev xeeb tub, Humalog Mix 50 tuaj yeem siv tsuas yog kho hauv tsev kho mob.

Yog tias cev xeeb tub tau tshwm sim thaum kho, koj yuav tsum ceeb toom koj tus kws kho mob, vim tias nyob rau lub sijhawm no nws tseem ceeb heev los saib xyuas tus mob thiab txheej txheem kev kho. Hauv thawj peb lub hlis, xav tau cov tshuaj insulin feem ntau poob qis, hauv kev txiav tawm zaum ob thiab thib peb uas nws nce. Thaum lub sijhawm yug thiab tom qab yug tas, yuav tsum muaj cov insulin tsawg zuj zus.

Thaum pub niam mis, cov pojniam muaj ntshav qab zib yuav xav tau koob tshuaj insulin thiab / lossis noj zaub mov kom haum.

Nrog lub siab ua haujlwm tsis zoo

Thaum lub siab ua haujlwm tsis txaus siab, Humalog Mix 50 yuav tsum tau siv nrog ceev faj, nyob rau hauv kev saib xyuas ntawm tus kws kho mob, vim tias qhov xav tau cov tshuaj insulin yuav poob vim qhov txo qis hauv lub peev xwm gluconeogenesis thiab txo qis hauv cov tshuaj insulin metabolism. Txawm li cas los xij, nyob rau hauv ntev daim siab tsis ua hauj lwm, nce insulin tsis kam yog ua tau, uas yuav tsum tau nce ntxiv ntawm koob tshuaj.

Yeeb tshuaj sib cuam tshuam

Hypoglycemic effect ntawm Humalog Mix 50 txo beta₂adrenergic agonists (xws li terbutaline, salbutamol, rhytodrine), glucocorticosteroids, phenothiazine derivatives, thiazide diuretics, thyroid hormone iodine, qhov ncauj tawm tsam, nicotinic acid, diazoxide, chlorprotixene, isoniazid, danazole.

Hypoglycemic txiav txim Humalog Mix 50 txhim khu qhov ncauj hypoglycemic agents, sulfa tshuaj tua kab mob, anabolic steroids, beta-blockers, angiotensin converting enzyme inhibitors (captopril, enalapril), angiotensin II receptor antagonists, tej antidepressants (monoamine oxidase inhibitors), salicylates (e.g., acetylsalicylic acid), tetracyclines ,ethanol thiab ethanol-muaj npaj, octreotide, guanethidine, fenfluramine.

Nrog rau kev siv cov tshuaj ntawm thiazolidinedione pab pawg, muaj kev pheej hmoo ntawm kev txhim kho edema thiab lub plawv tsis ua haujlwm, tshwj xeeb tshaj yog rau cov neeg mob uas muaj cov kab mob ntawm cov hlab plawv thiab muaj cov kev pheej hmoo ua rau mob plawv tsis ua haujlwm.

Reserpine, clonidine thiab beta-blockers tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib uas tau tsim nrog kev siv Humalog Mix 50.

Qhov sib cuam tshuam ntawm Humalog Mix 50 nrog rau lwm cov tshuaj insulin tsis tau kawm.

Txoj hauv kev siv lwm cov tshuaj thaum kho cov ntshav qab zib yuav tsum pom zoo nrog koj tus kws kho mob.

Analogues Humalog Mix 50 yog NovoMiks 30 Penfill, NovoMiks 30 FleksPen, NovoMiks 50 FleksPen, NovoMiks 70 FleksPen, Insulin aspart NovoRapid Penfill, NovoRapid FleksPen, Lantus SoloSTAR, Tudzheo SoloSTAR, Apidra, Homolong 40, insulin detemir, insulin lispro, Rosinsulin, Homo 40 thiab lwm tus.

Tus nqi ntawm Humalog Mix 50 hauv cov chaw muag tshuaj

Tus nqi kwv yees rau Humalog Mix 50 yog 1767–1998 rubles. rau 5 QuickPen 3 xaum npiv

Kev Kawm Ntawv: Thawj Moscow State Medical University muaj npe tom qab I.M. Sechenov, tshwj xeeb "Tshuaj General".

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Nws tau siv los ua yawning enriches lub cev nrog oxygen. Txawm li cas los xij, qhov kev pom no tau nthuav dav. Cov kws tshawb fawb tau ua pov thawj tias yawning, ib tus neeg ua kom lub hlwb txias thiab txhim kho kev ua haujlwm.

Tus neeg muaj kev kawm paub tsis yooj yim rau cov kab mob hlwb. Cov kev txawj ntse ua haujlwm koom nrog kev tsim cov ntaub so ntswg ntxiv los txhawb rau cov neeg mob.

Tus mob uas tsis tshua muaj mob yog Kuru's kab mob. Tsuas yog cov neeg sawv cev ntawm pawg neeg Fore hauv New Guinea mob nrog nws. Tus neeg mob tuag ntawm kev luag. Nws ntseeg tau tias qhov ua rau tus mob yog noj tib neeg lub hlwb.

Raws li ntau tus kws tshawb fawb, cov vitamins complex yog qhov tsis muaj txiaj ntsig rau tib neeg.

Ntxiv rau tib neeg, tsuas yog ib tus tsiaj muaj sia nyob ntawm ntiaj chaw ntiaj teb - dev, raug kev txom nyem los ntawm prostatitis. Cov no yog peb cov phooj ywg ncaj ncees tshaj plaws.

Qhov kub siab tshaj plaws ntawm lub cev tau sau cia ntawm Willie Jones (USA), uas tau nkag rau hauv tsev kho mob nrog qhov kub txog 46,5 ° C.

Muaj 74 xyoo nyob hauv tebchaws Australian yawg James Harrison tau los ua neeg muab ntshav li 1,000 zaus. Nws muaj ib hom ntshav uas tsis tshua muaj, cov tshuaj tiv thaiv uas pab cov menyuam mos liab uas muaj ntshav tsawg txaus kom ciaj sia taus. Yog li, Australian thiaj cawm tau ntau txog ob lab tus menyuam.

Thaum lub neej, tus neeg nruab nrab tsim tawm tsis tsawg tshaj li ob lub pas dej loj uas muaj qaub ncaug.

Lub siab yog qhov ua haujlwm hnyav tshaj plaws hauv peb lub cev. Nws qhov hnyav nruab nrab yog 1.5 kg.

Tib neeg cov pob txha yog plaub zaug muaj zog dua li cov pob zeb.

Hauv kev mob siab kom tau tus neeg mob tawm, cov kws kho mob feem ntau mus deb dhau. Yog li, piv txwv li, qee yam Charles Jensen nyob rau lub sijhawm txij xyoo 1954 txog 1994. muaj sia nyob ntau dua 900 lub neoplasm tshem tawm txoj haujlwm.

Hauv tebchaws Askiv muaj txoj cai lij choj raws li uas tus kws phais neeg tuaj yeem tsis kam ua haujlwm rau tus neeg mob yog tias nws haus luam yeeb lossis rog dhau. Ib tug neeg yuav tsum tso tawm tus cwj pwm tsis zoo, thiab tom qab ntawd, tej zaum, nws yuav tsis xav tau kev phais mob.

Raws li kev tshawb fawb, cov poj niam uas haus ob peb khob npias lossis cawv txiv hmab ib lim tiam muaj feem ntau yuav muaj mob khees xaws mis.

Peb lub raum tuaj yeem ntxuav peb liv cov ntshav hauv ib feeb.

Txawm hais tias ib tug neeg lub siab tsis yeej, tam sim no nws tseem tuaj yeem nyob rau lub sijhawm ntev, zoo li tus neeg nuv ntses neeg Norwegian Jan Revsdal tau ua rau peb pom. Nws "lub cev muaj zog" nres rau 4 xuab moos tom qab tus neeg nuv ntses tau ploj thiab tsaug zog hauv cov daus.

Tus naj npawb ntawm cov neeg ua haujlwm hauv chaw ua haujlwm tau nce siab hauv lub cev. Cov qauv no yog tshwj xeeb tshaj yog cov yam ntxwv ntawm cov nroog loj. Kev ua haujlwm hauv chaw ua haujlwm nyiam cov txiv neej thiab poj niam.

Cov tshuaj Insulin analogues: koj tuaj yeem hloov koj cov tshuaj li cas

Txhawm rau kom tshem tawm cov ntshav qab zib hauv kev kho mob, nws yog kev coj los siv insulin analogues.

Sij hawm dhau mus, cov tshuaj zoo li no tau dhau los ntawm cov kws kho mob thiab lawv cov neeg mob.

Tus qauv zoo li tuaj yeem piav qhia:

• qhov siab tsim nyog ntawm cov tshuaj insulin hauv kev tsim khoom,
• kev ruaj ntseg zoo tshaj plaws profile,
• yooj yim ntawm kev siv
• lub peev xwm los synchronize kev txhaj tshuaj nrog nws tus kheej zais cia ntawm cov tshuaj hormones.

Tom qab ib ntus, cov neeg mob uas muaj ntshav qab zib hom 2 mellitus raug yuam kom hloov los ntawm cov ntshav qab zib-txo cov ntsiav tshuaj mus rau kev txhaj tshuaj ntawm cov tshuaj insulin. Yog li no, lo lus nug ntawm kev xaiv cov tshuaj noj kom zoo rau lawv yog qhov tseem ceeb.

Cov yam ntxwv ntawm insulin niaj hnub

Muaj qee qhov kev txwv ntawm kev siv ntawm cov tshuaj insulin ntawm tib neeg, piv txwv li, qhov pib qeeb ntawm qhov kis (tus mob ntshav qab zib yuav tsum tau txhaj tshuaj 30-40 feeb ua ntej noj mov) thiab lub sijhawm ua haujlwm ntev dhau lawm (txog 12 teev), uas tuaj yeem dhau los ua qhov yuav tsum tau ua kom ncua qis rau lub qog ntshav qab zib.

Thaum kawg ntawm lub xyoo pua xeem, qhov kev xav tau tshwm sim los tsim cov tshuaj insulin uas yuav tso tau qhov tsis muaj qhov tsis txaus no. Cov yeeb yaj kiab luv ua haujlwm pib tsim muaj nrog luv-lub neej luv luv tau.

Qhov no coj lawv los ze zog rau cov khoom ntawm insulin haiv neeg, uas tuaj yeem ua rau tsis muaj zog tom qab 4-5 feeb tom qab nkag rau hauv cov hlab ntshav.

Peakless cov kua dej tsis sib xws tuaj yeem sib txig sib luag thiab ntseeg tau los ntawm cov roj ntsha subcutaneous thiab tsis ua rau lub cev tsis muaj ntshav ntau.

Xyoo tsis ntev los no, tau muaj kev pom zoo tseem ceeb hauv chaw muag tshuaj, vim nws sau tseg:

• qhov kev hloov ntawm acidic daws teeb meem rau qhov nruab nrab,
• txais tib neeg cov tshuaj insulin siv cov thev naus laus zis DNA thev naus laus zis,
• kev tsim cov siab zoo hloov pauv insulin nrog cov yam ntxwv pharmacological tshiab.

Insulin analogs pauv hloov lub sijhawm ntawm qhov kev ua ntawm tib neeg los ua tib neeg los muab ib tus neeg physiological mus kom ze rau kev kho thiab qhov yooj yim tshaj plaws rau cov ntshav qab zib.

Cov tshuaj ua rau nws ua tiav kom ua tiav txoj kev sib txig sib luag ntawm kev pheej hmoo ntawm kev poob ntshav qab zib thiab kev ua tiav ntawm lub hom phiaj glycemia.

Cov tshuaj hnub tshiab ntawm cov tshuaj insulin raws li lub sijhawm ntawm nws qhov kev txiav txim siab feem ntau muab faib ua:

1. ultrashort (Humalog, Apidra, Novorapid Penfill),
2. lub sijhawm ntev (Daim roj Hmo, Levemir Penfill).

Tsis tas li ntawd, muaj cov tshuaj sib xyaw ua ke ntawm kev hloov pauv, uas yog ib qho kev sib xyaw ntawm ultrashort thiab lub cev ntev nyob hauv ib qho kev sib piv: Penfill, Humalog sib tov 25.

Humalog (lispro)

Hauv cov qauv ntawm cov tshuaj insulin no, txoj haujlwm ntawm kab thiab lysine tau hloov pauv. Qhov sib txawv ntawm cov tshuaj thiab cov tib neeg kho cov tshuaj lom neeg tsis muaj zog yog qhov tsis muaj qhov txawv txav ntawm cov koom haum sib txuas. Hauv kev pom ntawm qhov no, lispro tuaj yeem nqus tau sai rau hauv cov hlab ntshav ntawm cov ntshav qab zib.

Yog tias koj txhaj tshuaj rau hauv tib lub tshuaj thiab tib lub sijhawm, Tom qab ntawd Humalog yuav muab qhov siab tshaj 2 zaug sai dua. Qhov no cov tshuaj hormones yog tshem tawm ntau nrawm dua thiab tom qab 4 teev nws qhov kev kub siab tuaj txog nws qib pib. Qhov kev cia siab ntawm cov tshuaj insulin rau tib neeg yuav raug tswj nyob hauv 6 teev.

Muab piv rau lyspro nrog luv luv ua yeeb yam insulin, peb tuaj yeem hais tias tus qub tuaj yeem txwv kev tsim cov piam thaj los ntawm daim siab ntau ntau.

Muaj lwm qhov zoo dua ntawm cov tshuaj Humalog - nws yog qhov kom paub tseeb tseeb dua ntxiv thiab tuaj yeem pab lub sijhawm muab tshuaj kho rau cov zaub mov ntsaws kom zoo dua. Nws yog tus yam ntxwv los ntawm qhov tsis muaj qhov hloov ntawm lub sijhawm ua haujlwm los ntawm kev nce hauv lub ntim ntawm cov tshuaj nkag.

Siv tib neeg cov tshuaj insulin, lub sijhawm ua haujlwm ntawm nws txoj haujlwm yuav txawv nyob ntawm koob tshuaj. Nws yog los ntawm qhov no hais tias qhov nruab nrab li ntawm 6 txog 12 teev tshwm sim.

Nrog rau kev nce ntxiv hauv cov tshuaj ntawm cov tshuaj insulin Humalog, lub sijhawm ua haujlwm nws tseem yuav luag nyob rau tib theem thiab yuav yog 5 teev.

Nws ua raws tias nrog kev nce ntxiv ntawm cov koob tshuaj lispro, qhov kev pheej hmoo ntawm lub qog ntshav qab zib tsis nce.

Aspart (Novorapid Penfill)

Cov tshuaj insulin no tuaj yeem ua rau zoo tiav raws li cov tshuaj insulin txaus rau kev noj zaub mov. Nws lub sijhawm luv luv ua rau muaj kev cuam tshuam tsis tshua zoo rau ntawm kev noj mov, uas ua rau nws muaj peev xwm ua kom tiav kev tswj xyuas kom ua tiav cov ntshav qab zib.

Yog tias peb piv cov txiaj ntsig ntawm kev kho mob nrog insulin analogues nrog cov neeg ua yeeb yam luv luv rau tib neeg, nws qhov tseem ceeb hauv kev tswj hwm tau zoo ntawm cov ntshav qab zib tom qab qib siab yuav raug sau tseg.

Ua ke nrog kev kho mob nrog Detemir thiab Aspart muab lub sijhawm:

• yuav luag 100% normalize rau daim ntawv qhia txhua hnub ntawm cov tshuaj insulin,
• txhawm rau txhim kho qib ntawm glycosylated hemoglobin,
• txo txoj kev pheej hmoo ntawm kev txhim kho hypoglycemic,
• txo cov kev ua kom ntau thiab cov ntsiab lus ntawm cov ntshav qab zib ntawm ntshav qab zib.

Nws yog qhov tsim nyog hais tias thaum lub sij hawm kho nrog basal-bolus insulin analogues, qhov nruab nrab ntawm lub cev qhov hnyav tau qis dua qis dua rau tag nrho lub sijhawm ntawm kev tshuaj xyuas zoo.

Glulisin (Apidra)

Tus tib neeg cov tshuaj insulin analog Apidra yog cov tshuaj tiv thaiv ultra-luv.

Raws li nws cov pharmacokinetic, cov yam ntxwv pharmacodynamic thiab kev nyab xeeb ntawm cev, Glulisin yog qhov sib npaug nrog Humalog.

Hauv nws qhov kev ua kom zoo thiab metabolic, yam tshuaj no tsis txawv ntawm tib neeg insulin. Ua tsaug rau qhov no, nws yog qhov tsim nyog siv nws rau lub sijhawm ntev, thiab nws muaj kev nyab xeeb kiag li.

Raws li txoj cai, Apidra yuav tsum tau siv nrog:

1. ntev insulin tib neeg
2. basal insulin analogue.

Tsis tas li ntawd, cov tshuaj yeeb tshuaj yog tus cwj pwm los ntawm kev pib ua haujlwm sai thiab nws lub sijhawm luv dua li ib txwm muaj tib neeg lawm.

Nws tso cai rau cov neeg mob ntshav qab zib kom pom qhov ua kom yooj yim hauv kev siv nws nrog zaub mov ntau dua li tib neeg kev noj tshuaj.

Cov tshuaj Insulin pib nws cov nyhuv tam sim ntawd tom qab kev tswj hwm, thiab cov ntshav qab zib cov ntshav poob 10-20 feeb tom qab Apidra tau txhaj tshuaj subcutaneously.

Txhawm rau kom tsis txhob mob ntshav qab zib hauv cov neeg laus, cov kws kho mob pom zoo kom qhia cov tshuaj tam sim ntawd tom qab noj mov lossis hauv tib lub sijhawm. Lub sij hawm txo qis ntawm cov tshuaj no yuav pab kom tsis txhob muaj qhov hu ua "overlay" nyhuv, uas ua rau nws tiv thaiv kom tsis txhob mob ntshav qab zib.

Glulisin tuaj yeem siv tau rau cov neeg rog dhau los, vim tias nws qhov kev siv tsis ua rau nce phaus ntxiv. Cov tshuaj yog tus cwj pwm los ntawm kev pib sai ntawm qhov kev xav ntau tshaj piv nrog lwm hom kev noj tshuaj tsis tu ncua thiab lispro.

Apidra yog qhov zoo rau ntau qib ntawm kev hnyav dhau vim nws txoj kev hloov pauv ntau. Hauv visceral hom kev rog, qhov nqus ntawm cov tshuaj tuaj yeem sib txawv, ua rau nws nyuaj rau kev tswj hwm glycemic.

Kev tshuaj xyuas (Levemir Penfill)

Levemir Penfill yog ib qho tshuaj tiv thaiv ntawm tib neeg cov tshuaj insulin. Nws muaj lub sijhawm ua haujlwm nruab nrab thiab tsis muaj peaks. Qhov no pab kom cov hauv paus tswj glycemic tswj thaum nruab hnub, tab sis raug siv ob npaug.

Thaum muab tshuaj subcutaneously, Detemir tsim cov tshuaj uas khi rau cov ntshiab albumin hauv cov kua dej interstitial. Tom qab hloov mus los ntawm phab ntsa capillary, insulin rov khi rau albumin hauv cov hlab ntshav.

Hauv kev npaj, tsuas yog cov seem dawb yog kev ua haujlwm biologically. Yog li ntawd, khi rau albumin thiab nws cov hniav qeeb tau muab kev ua haujlwm ntev thiab siab kawg.

Levemir Penfill insulin ua rau tus neeg mob ntshav qab zib kom zoo thiab ua tiav nws txoj kev xav tau tag nrho cov tshuaj insulin basal.Nws tsis muab kev co ua ntej ua haujlwm subcutaneous.

Glargin (Lub Teeb)

Glargin insulin hloov pauv yog ultra-nrawm. Cov tshuaj no tuaj yeem ua tau zoo thiab ua kom tiav nyob hauv ib puag ncig acidic me ntsis, thiab hauv nruab nrab nruab nrab (hauv cov rog muaj roj) nws yog cov dej tsis zoo.

Tam sim ntawd tom qab kev tswj hwm subcutaneous, Glargin nkag mus rau hauv qhov kev tiv thaiv nruab nrab nrog kev tsim cov microprecipitation, uas yog qhov tsim nyog rau kev tso tawm ntxiv ntawm cov tshuaj hexamers thiab lawv cais ua rau insulin hormone monomers thiab dimers.

Vim tias txoj kev nqus thiab maj mam khiav ntawm Lantus rau hauv cov ntshav ntawm tus neeg mob ntshav qab zib, nws cov ntshav ncig hauv cov channel tshwm sim hauv 24 teev. Qhov no ua rau nws muaj peev xwm txhaj tshuaj insulin analogues ib zaug ib hnub.

Thaum ib qho me me ntawm zinc ntxiv, insulin Lantus crystallizes nyob rau hauv subcutaneous txheej ntawm fiber ntau, uas ntxiv rau lengthens nws lub sijhawm nqus. Kiag li ntawm tag nrho cov kev zoo ntawm cov tshuaj no lav nws cov ntaub ntawv du thiab tsis muaj dab tsi.

Glargin pib ua haujlwm tom qab 60 feeb tom qab txhaj tshuaj subcutaneous. Nws txoj kev xav nyob ruaj khov hauv tus neeg mob ntshav plasma tuaj yeem pom tom qab 2-4 teev txij li lub sijhawm muab tshuaj thawj zaug.

Tsis hais txog lub sijhawm txhaj tshuaj ntawm cov tshuaj no ultrafast (yav sawv ntxov lossis yav tsaus ntuj) thiab qhov chaw txhaj tshuaj (lub plab, caj npab, ceg), lub sijhawm uas raug rau lub cev yuav yog:

• nruab nrab - 24 teev
• qhov siab tshaj plaws - 29 teev.

Kev hloov pauv ntawm cov tshuaj insulin Glargin tuaj yeem hloov kho lub cev ntawm lub cev hormone hauv nws qhov kev ua haujlwm siab, vim hais tias cov tshuaj:

1. zoo txhawb kev noj cov piam thaj los ntawm cov ntaub so ntswg ib feem ntau nyob ntawm insulin (tshwj xeeb tshaj yog cov rog thiab cov leeg),
2. inhibits gluconeogenesis (txo qis ntshav qabzib).

Tsis tas li ntawd, cov tshuaj cuam tshuam rau qhov cuam tshuam ntawm cov ntaub so ntswg adipose (lipolysis), kev ua kom cov protein tsis zoo (tiv thaiv kab mob), thaum kho cov nqaij hauv cov leeg.

Kev tshawb fawb txog kev kho mob ntawm Glargin's pharmacokinetics tau qhia tias tsis muaj kev faib tawm ntau kawg ntawm cov tshuaj no ua rau nws muaj peev xwm yuav luag 100% mimic qhov pib ntawm kev tsim cov tshuaj endogenous hormone insulin hauv 24 teev. Nyob rau tib lub sijhawm, qhov ntxim nyiam ntawm kev txhim kho hypoglycemic tej yam kev mob thiab cov ntshav siab ntxiv hauv cov ntshav qab zib kom tsawg.

Neej Neeg tshaj 25

Cov tshuaj no yog kev sib xyaw uas muaj:

• 75% tiv thaiv kev ncua ntawm cov tshuaj hormones lispro,
• 25% insulin Humalog.

Qhov no thiab lwm yam tshuaj insulin kuj tseem ua ke raws li lawv cov kev tso tawm txheej txheem. Lub sijhawm zoo tshaj plaws ntawm cov tshuaj tau muab vim qhov cuam tshuam ntawm kev tiv thaiv kev tiv thaiv ntawm kev sib deev lyspro, uas ua rau nws tuaj yeem rov ua lub hauv paus pib ntawm cov tshuaj hormone.

Qhov tshuav 25% ntawm insulin lispro yog ib qho kev tiv thaiv nrog lub sijhawm luv luv ntawm lub sijhawm ntev, uas cuam tshuam rau glycemia tom qab noj mov.

Nws yog ib qho tseem ceeb tshaj plaws tias lub Humalog hauv cov lus sib xyaw ua tiav cuam tshuam rau lub cev tau nrawm dua piv nrog cov tshuaj hormones luv luv. Nws muab kev tswj siab tshaj plaws ntawm postpradial glycemia thiab vim li ntawd nws cov ntaub ntawv qhia tau ntau physiological thaum piv nrog luv luv ua yeeb yam insulin.

Cov tshuaj insulins tshwj xeeb yog pom zoo rau cov neeg muaj ntshav qab zib hom 2. Pab pawg no suav nrog cov neeg laus laus uas, raws li txoj cai, raug kev txom nyem los ntawm teeb meem nco. Tias yog vim li cas qhov kev qhia ntawm cov tshuaj hormones ua ntej noj mov lossis tam sim ntawd tom qab nws pab txhim kho kev ua neej zoo ntawm cov neeg mob ntawd.

Cov kev tshawb fawb txog kev noj qab haus huv ntawm cov neeg mob ntshav qab zib nyob hauv cov pab pawg hnub nyoog txij li 60 txog 80 xyoo uas siv cov tshuaj Humalog sib xyaw 25 qhia tau hais tias lawv tswj tau txais cov txiaj ntsig zoo rau cov metabolism hauv kev noj haus.Hauv kev coj los tswj cov tshuaj ua ntej thiab tom qab noj mov, cov kws kho mob tau tswj hwm kom maj mam nce thiab ua rau lub cev tsis muaj ntshav qab zib tsawg.

Nws yog ib qho zoo insulin?

Yog tias peb sib piv cov tshuaj pharmacokinetics ntawm cov tshuaj hauv cov lus nug, lawv cov kev teem sijhawm los ntawm tus kws kho mob mus koom tau yog qhov tseeb tau yog tias muaj ntshav qab zib mellitus, ob hom tshuaj thawj thiab thib ob. Qhov sib txawv tseem ceeb ntawm cov insulins no yog qhov uas tsis muaj qhov hnyav hauv lub cev thaum kho thiab txo qis ntawm cov ntshav pauv thaum tsaus ntuj hauv lub siab.

Tsis tas li ntawd, nws yog ib qho tseem ceeb kom pom tias yuav tsum tau txhaj tshuaj ib hnub xwb, uas yooj yim dua rau cov neeg mob.

Qhov tshwj xeeb tshaj yog qhov tseem ceeb ntawm Glargin tib neeg insulin analogue ua ke nrog metformin rau cov neeg mob ntshav qab zib hom 2.

Cov kev tshawb fawb tau pom qhov tseem ceeb txo qis rau yav hmo ntuj cov kab tsuag zoo nyob hauv thaj chaw qab zib. Qhov no yuav pab kom ntseeg siab tau normalize glycemia txhua hnub.

Kev sib xyaw ntawm Lantus nrog cov tshuaj noj hauv qhov ncauj kom txo qis ntshav qab zib tau kawm hauv cov neeg mob uas tsis tuaj yeem them nyiaj mob ntshav qab zib.

Lawv yuav tsum tau taw Glargin sai li sai tau. Cov tshuaj no tuaj yeem raug pom zoo rau kev kho mob nrog tus kws kho mob endocrinologist thiab cov kws kho mob zaws.

Kev kho hnyav nrog Lantus ua rau nws muaj peev xwm txhim kho glycemic tswj hwm hauv txhua pab pawg ntawm cov neeg mob ntshav qab zib mellitus.

Ultrashort insulin Humalog thiab nws cov analogues - dab tsi yog qhov zoo dua los siv rau ntshav qab zib?

Tsis pom qhov mob ntshav qab zib yog hu ua tus kab mob ntawm lub xyoo pua. Tus naj npawb ntawm cov neeg mob nrog qhov kev kuaj mob no tau nce ntxiv txhua xyoo.

Txawm hais tias cov ua rau tus kab mob sib txawv, kev muaj keeb yog qhov tseem ceeb. Kwv yees li 15% ntawm tag nrho cov neeg mob muaj mob ntshav qab zib hom 1. Txog kev kho lawv xav tau cov tshuaj insulin.

Feem ntau, cov tsos mob ntawm tus mob ntshav qab zib hom 1 tshwm sim thaum menyuam yaus lossis thaum tiav hluas. Tus kabmob yog yam ntxwv ntawm nws txoj kev loj hlob sai. Yog hais tias ntsuas tsis tau ua nyob rau hauv lub sijhawm, cov teeb meem tuaj yeem ua rau lub cev tsis ua haujlwm ntawm ib tus neeg, lossis tag nrho lub cev.

Kev hloov pauv ntawm cov tshuaj insulin tuaj yeem nqa tawm uas siv Humalog, analogues ntawm cov tshuaj no. Yog tias koj ua raws txhua cov lus qhia ntawm tus kws kho mob, tus neeg mob tus mob yuav nyob ruaj khov. Cov tshuaj yog qhov qhia tawm ntawm tib neeg cov tshuaj insulin.

Rau nws siv thiab ua, DNA cuav yog xav tau. Nws muaj cov yam ntxwv ntawm tus yam ntxwv - nws pib ua sai sai heev (hauv 15 feeb). Txawm li cas los xij, lub sijhawm tiv thaiv tsis dhau 2-5 teev tom qab kev saib xyuas ntawm cov tshuaj.

Lub ntsiab active tshuaj

Cov tshuaj yog xim tsis muaj kob pob tshab uas tau daws, muab tso rau hauv daim cartridges (1.5, 3 ml) lossis ntim fwj (10 ml). Nws muab tshuaj rau leeg. Cov tshuaj nquag ntawm cov tshuaj yog insulin lispro, diluted nrog cov khoom ntxiv.

Cov khoom siv ntxiv muaj xws li:

1. metacresol
2. glycerol
3. zinc oxide
4. sodium hydrogen phosphate,
5. 10% hydrochloric acid daws,
6. 10% sodium hydroxide tov,
7. distilled dej.

Cov tshuaj muaj feem cuam tshuam nrog kev tswj kev ua qabzib, ua cov teebmeem anabolic.

Kev ntsuas ntawm ATC Qib 3

Ntau tshaj peb lub tshuaj muaj ntau yam sib txawv, tab sis zoo sib xws hauv kev qhia, txoj kev siv.

Lub npe ntawm qee qhov analogues ntawm Humalog raws li ATC code qib 3:

• Biosulin N,
• Insuman Bazal,
• Protafan
• Humodar b100r,
• Gensulin N,
• Insugen-N (NPH),
• Protafan NM.

Humalog thiab Humalog Mix 50: sib txawv

Nws yog ib qho tseem ceeb kom paub! Teeb meem muaj suab thaj ntau dhau sijhawm tuaj yeem ua rau tag nrho cov kab mob, xws li teeb meem nrog lub zeem muag, tawv nqaij thiab plaub hau, mob rau sab hauv, mob caj pas thiab txawm tias mob qog nqaij hlav! Cov neeg qhia kev iab siab rau normalize lawv qab zib kom txaus siab ...

Qee tus neeg mob ntshav qab zib xav yuam kev xav txog cov tshuaj no kom suav daws noj tshuaj. Qhov no tsis yog. Qhov nruab nrab tshuaj tiv thaiv Hagedorn (NPH), uas ua rau qeeb qis ntawm kev ua haujlwm ntawm insulin, yog qhia rau hauv Humalog sib tov 50.

Qhov ntau tshaj ntawm cov tshuaj ntxiv, ntev dua qhov kev txhaj tshuaj ua haujlwm. Nws qhov nrov ntawm cov ntshav qab zib yog vim qhov tseeb tias nws ua kom yooj yim cov kev cai ntawm kev kho tshuaj insulin.

Humalog Sib tov 50 daim cartridges 100 IU / ml, 3 ml hauv Kev Sau Npe Ceev ceev

Tus naj npawb ntawm cov hno txhua hnub txo, tab sis qhov no tsis muaj txiaj ntsig rau txhua tus neeg mob. Nrog rau kev txhaj tshuaj, nws nyuaj rau kev tswj ntshav qab zib kom ua tau zoo. Ib qho ntxiv, cov tshuaj tiv thaiv nruab nrab lub cev Hagedorn feem ntau ua rau ua xua kev tiv thaiv hauv cov neeg mob ntshav qab zib.

Humalog sib tov 50 tsis pom zoo rau cov menyuam yaus, cov neeg mob hnub nyoog ib nrab. Qhov no tso cai rau lawv kom tsis txhob muaj mob ntshav qab zib thiab mob ntev ntev.

Feem ntau, cov tshuaj insulin ntev ntev tau kho rau cov neeg laus, uas, vim muaj cov yam ntxwv ntsig txog lub hnub nyoog, tsis nco qab ua kom mus txhaj tshuaj kom raws sijhawm.

Humalog, Novorapid lossis Apidra - uas yog qhov zoo dua?

Piv nrog tib neeg cov tshuaj insulin, cov tshuaj saum toj no tau txais artificially.

Lawv cov mis ua kom zoo dua tuaj yeem ua rau kom muaj suab thaj tsawg dua.

Tib neeg cov kua dej pib ua nyob rau hauv ib nrab ib teev, nws cov tshuaj lom neeg cov tshuaj tiv thaiv rau cov tshuaj tiv thaiv yuav xav tau tsuas yog 5-15 feeb. Humalog, Novorapid, Apidra yog cov tshuaj ultrashort tsim los txo cov ntshav qab zib kom sai.

Ntawm txhua cov tshuaj, qhov haib tshaj yog Humalog.Cov. Nws ua rau cov ntshav qab zib 2.5 zaug ntau dua li cov neeg insulin luv.

Novorapid, Apidra yog qee yam tsis muaj zog. Yog tias koj sib piv cov tshuaj no nrog tib neeg cov tshuaj insulin, nws hloov tawm tias lawv yog 1.5 npaug zog dua li tom kawg.

Kev muab tshuaj tshwj xeeb los kho mob ntshav qab zib yog kws kho mob lub luag haujlwm. Tus neeg mob tau ntsib nrog lwm cov haujlwm uas yuav ua rau nws tiv nrog tus kab mob: nruj mas ua raws li kev noj haus, kws kho mob cov lus pom zoo, kev nqis tes ua lub cev tsim nyog.

Hais txog cov yam ntxwv ntawm kev siv insulin Humalog hauv video:

Insulin Humalog: yuav ua li cas thov, ntau npaum li cas yog qhov siv tau thiab nqi

Dua li ntawm qhov tseeb hais tias cov kws tshawb fawb tswj tau kom rov ua tiav cov tshuaj insulin molecule, uas tsim tawm hauv tib neeg lub cev, qhov kev ua ntawm cov tshuaj hormones tseem ua rau qeeb qeeb vim lub sijhawm xav kom nqus mus rau hauv cov ntshav. Thawj cov tshuaj ntawm kev ua kom zoo dua yog cov tshuaj insulin Humalog. Nws pib ua haujlwm tau ntev lawm 15 feeb tom qab txhaj tshuaj, yog li ntawd cov suab thaj los ntawm cov ntshav pauv mus rau cov ntaub so ntswg hauv lub sijhawm, thiab txawm tias lub sijhawm luv luv hyperglycemia tsis tshwm sim.

Piv nrog rau cov neeg tsim insulins yav dhau los, Humalog qhia tau zoo dua: hauv cov neeg mob, txhua hnub hloov pauv hauv qab zib yog 22%, glycemic qhov ntsuas tau zoo, tshwj xeeb tshaj yog yav tav su, thiab qhov muaj feem yuav ua rau lub cev txo qis ntshav qab zib tsawg dua. Vim tias qhov nrawm nrawm, tab sis qhov kev txiav txim ruaj khov, qhov insulin no nce hauv kev mob ntshav qab zib.

Nyob zoo Kuv lub npe yog Galina thiab kuv tsis muaj ntshav qab zib ntxiv lawm! Nws coj kuv tsuas yog 3 lub lis piamcoj qab zib rov qab mus rau qhov qub thiab tsis quav cov tshuaj tsis raug cai
>>Koj tuaj yeem nyeem kuv zaj dab neeg ntawm no.

Qhia me ntsis

Cov lus qhia txog kev siv tshuaj insulin Humalog yog qhov hluav taws xob heev, thiab cov ntu piav qhia txog kev phiv thiab cov lus qhia rau kev siv nyob ntau dua ib kab lus.

Cov lus piav qhia ntev ntev uas sib xyaw nrog qee cov tshuaj tau pom los ntawm cov neeg mob yog lus ceeb toom txog kev phom sij ntawm kev coj lawv.

Qhov tseeb, txhua yam muaj qhov sib txawv: ib qho loj, cov lus qhia ntxaws ntxaws - cov ntaub ntawv pov thawj ntawm ntau yam kev sim siabtias cov tshuaj no thev taus zoo.

Humalogue tau txais kev pom zoo rau kev siv ntau dua 20 xyoo dhau los, thiab tam sim no nws muaj kev ruaj ntseg hais tias cov tshuaj insulin no muaj kev nyab xeeb ntawm kev siv tshuaj. Nws tau txais kev pom zoo rau kev siv los ntawm ob tus neeg laus thiab menyuam yaus; nws tuaj yeem siv rau hauv txhua kis nrog los ntawm kev tsis muaj tshuaj tiv thaiv hnyav: hom 1 thiab hom 2 mob ntshav qab zib, mob ntshav qab zib hauv lub cev, thiab phais mob phais.

Cov ntaub ntawv dav dav txog qhov Humalogue:

Ntawm cov kev mob tshwm sim, hypoglycemia thiab kev fab tshuaj tsis haum yog feem ntau pom (1-10% ntawm neeg mob ntshav qab zib). Tsawg dua 1% ntawm cov neeg mob tsim muaj lipodystrophy ntawm thaj chaw txhaj tshuaj. Qhov ntau zaus ntawm lwm cov kev tsis sib haum yog tsawg dua 0.1%.

Qhov Tseem Ceeb Tshaj Txog Neeg Yuav Tsum

Hauv tsev, Humalog yog tswj hwm subcutaneously siv rab koob xaum qhuav los yog lub tshuab nqus insulin. Yog tias muaj mob loj heev yuav tsum raug tshem tawm, kev tswj hwm cov tshuaj no kuj tuaj yeem ua rau hauv chaw kho mob. Hauv qhov no, nquag tswj cov piam thaj yog qhov tsim nyog kom tsis txhob noj ntau dhau.

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj yog insulin lispro. Nws txawv ntawm tib neeg cov tshuaj hormones hauv kev npaj cov amino acids hauv cov qauv molecule. Xws li kev hloov kho tsis tiv thaiv cov cell receptors los ntawm kev paub txog cov tshuaj hormones, yog li lawv yooj yim dhau suab thaj rau lawv tus kheej.

Qhov humalogue tsuas muaj cov tshuaj insulin monomers - ib qho, tsis txuas yam tsis txawv. Vim tias qhov no, nws yog nqus tau nrawm thiab tusyees, pib txo cov piam thaj sai dua li cov tshuaj insulin tsis haum.

Qhov tshuaj Humalog yog qhov tshuaj yeeb-luv dua li piv txwv li, Humulin lossis Actrapid. Raws li kev faib tawm, nws tau xa mus rau cov tshuaj insulin analogues nrog cov kev ua kom raug.

Qhov pib ntawm nws cov kev ua tau nrawm dua, li 15 feeb, yog li cov neeg mob ntshav qab zib tsis tas tos kom txog thaum cov tshuaj ua haujlwm, tab sis koj tuaj yeem npaj zaub mov noj tom qab txhaj tshuaj.

Ua tsaug rau qhov tsis txaus no, nws yuav yooj yim rau kev npaj zaub mov noj, thiab qhov kev pheej hmoo tsis nco qab cov zaub mov tom qab kev txhaj tshuaj yog txo qis dua.

Rau kev tswj cov glycemic zoo, kev siv tshuaj tua kab mob sai yuav tsum tau ua ke nrog qhov tsim nyog siv ntawm cov insulin ntev. Tib qho kev zam tsuas yog kev siv lub tshuab nqus dej twj tso kua mis rau ntawm lub sijhawm txuas ntxiv.

Xaiv xaiv

Kev noj tshuaj Humalog ntau nyob ntawm ntau yam thiab txiav txim siab ntawm tus kheej rau txhua tus mob ntshav qab zib. Kev siv cov qauv txheem yog tsis pom zoo, vim tias lawv ua rau kev mob ntshav qab zib hnyav dua.

Yog tias tus neeg mob ua raws li cov zaub mov tsis zoo, lub cev ntawm Humalog yuav tsawg dua li tus qauv ntawm cov thawj coj tuaj yeem muab tau. Hauv qhov no, nws pom zoo kom siv cov tshuaj insulin uas tsis muaj zog tuaj.

Nws yog ib qho tseem ceeb heev: Tsis txhob niaj hnub noj cov tshuaj mafia. Endocrinologist ua rau peb tsis muaj nyiaj txaus siv tshuaj noj thaum muaj ntshav qab zib tuaj yeem li qub tau tsuas yog 147 rubles ... >>nyeem zaj dab neeg ntawm Alla Viktorovna

Ultrashort cov tshuaj hormones muab cov nyhuv loj tshaj. Thaum hloov mus rau Humalog, nws qhov kev pib noj tshuaj yog xam raws li 40% ntawm kev siv insulin luv luv. Raws li cov txiaj ntsig ntawm glycemia, ntau npaum li cas tau kho. Qhov xav tau qhov nruab nrab ntawm kev npaj rau ib khob cij yog 1-1.5 units.

Cov qauv kev txhaj tshuaj

Lub humalogue yog pricked ua ntej txhua pluas noj, tsawg kawg peb zaug hauv ib hnubCov. Nyob rau hauv cov ntaub ntawv ntawm cov piam thaj siab, kho cov menyuam hlob nyob nruab nrab ntawm kev txhaj tshuaj tseem ceeb raug tso cai. Cov kev qhia rau kev siv pom zoo xam lub xav tau ntawm cov tshuaj insulin raws li cov khoom noj uas tau npaj rau kev noj haus tom ntej. Txog 15 feeb yuav tsum dhau los ntawm kev txhaj tshuaj mus rau cov zaub mov.

Raws li kev txheeb xyuas, lub sijhawm no feem ntau tsawg dua, tshwj xeeb yog thaum tav su, thaum cov tshuaj tiv thaiv insulin tsawg dua. Qhov nqus tus nqi yog nruj me ntsis rau ib tus neeg, nws tuaj yeem raug suav siv rov ua ntsuas ntsuas cov ntshav qab zib sai sai tom qab txhaj. Yog tias cov ntshav qab zib ua rau pom qhov cuam tshuam sai dua li cov lus qhia, lub sijhawm ua ntej noj mov yuav tsum raug txo kom tsawg.

Humalog yog ib qho ntawm cov tshuaj sai tshaj plaws, yog li ntawd nws yooj yim siv nws ua kev pabcuam thaum muaj xwm ceev rau cov ntshav qab zib yog tias tus neeg mob tau hem nrog hyperglycemic coma.

Lub sijhawm ua haujlwm (luv lossis ntev)

Lub ncov ntawm ultrashort insulin yog pom 60 feeb tom qab nws tswj hwm. Lub sijhawm ua haujlwm nyob ntawm lub koob tshuaj; qhov loj dua nws yog, ntev li ntawm cov suab thaj txo qis dua yog nyob nruab nrab - txog 4 teev.

Neej Neeg tshaj 25

Txhawm rau kom ntsuas qhov tseeb ntawm qhov tshwm sim ntawm Humalog, qabzib yuav tsum tau ntsuas tom qab lub sijhawm no, feem ntau qhov no ua tiav ua ntej noj mov tom ntej. Kev ntsuas ua ntej yog xav tau yog xav tias tsam lub qog ntshav qab zib tsawg.

Lub sijhawm luv luv ntawm lub Humalog tsis yog qhov ua tsis zoo, tab sis qhov zoo ntawm cov tshuaj. Ua tsaug rau nws, cov neeg mob ntshav qab zib mellitus tsis tshua muaj kev tiv thaiv ntshav qab zib, tshwj xeeb tshaj yog thaum tsaus ntuj.

Humalog analogues thiab tus nqi

Daim ntawv noj tshuaj:subcutaneous kev ncua

Pharmacological kev txiav txim:

Kev sib xyaw ntawm lyspro insulin - kev ua yeeb yam sai sai thiab kev tiv thaiv tshuaj tiv thaiv ntawm lyspro insulin - nruab nrab ua yeeb yam insulin.

Lyspro insulin yog qhov tso tawm DNA ntawm tib neeg cov tshuaj insulin; nws txawv ntawm nws los ntawm kev rov qab los ntawm proline thiab lysine amino acid seem ntawm txoj haujlwm 28 thiab 29 ntawm cov kab insulin B. Regulates glucose metabolism, muaj cov nyhuv anabolic. Hauv cov leeg nqaij thiab lwm tus.

cov ntaub so ntswg (tsuas yog lub hlwb) tshwj xeeb tshaj yog ua kom muaj kev hloov pauv ntawm cov piam thaj thiab amino acids mus rau lub cell, txhawb kev tsim cov glycogen los ntawm cov piam thaj hauv lub siab, inhibits gluconeogenesis thiab txhawb kev hloov pauv ntawm cov piam thaj mus rau cov rog. Equimolar rau tib neeg cov tshuaj insulin.

Piv nrog tib neeg cov tshuaj insulin, nws muaj qhov tshwm sim ntawm kev pib sai dua, kev pib ua tiav ntawm qhov siab kawg thiab lub sijhawm luv dua ntawm kev ua haujlwm hypoglycemic (txog 5 teev).

Kev pib sai ntawm kev nqis tes ua (15 feeb tom qab kev tswj hwm) cuam tshuam nrog kev nqus siab thiab tso cai rau nws ua sai sai ua ntej noj mov (15 feeb) - tib neeg cov tshuaj insulin raug tswj hauv 30 feeb. Kev xaiv ntawm qhov chaw txhaj tshuaj thiab lwm yam tuaj yeem cuam tshuam tus nqi ntawm kev nqus thiab pib ntawm nws cov kev ua. Qhov siab tshaj plaws tau pom ntawm 0.5 thiab 2.5 teev, lub sijhawm ua ntawm 3-4 teev.

Kev Taw Qhia:

Yam 1 mob ntshav qab zib mellitus, tshwj xeeb nrog kev tsis nkag siab ntawm lwm cov insulins, postprandial hyperglycemia, uas tsis tuaj yeem kho los ntawm lwm tus.

insulin: mob subcutaneous insulin tsis ua hauj lwm (ua kom tsis muaj zog insulin hauv zos). Hom 2 mob ntshav qab zib mellitus - nyob rau hauv kis ntawm tsis kam mus rau qhov ncauj hypoglycemic tshuaj, nrog kev tsis haum ntawm lwm tus.

insulin, thaum lub sijhawm ua haujlwm, cov kabmob sib kis.

Cov Tshuaj Tiv Thaiv:

Kev ua haujlwm tsis txaus ntseeg, kev ua ntshav qab zib, insulinoma.

Phiv los sis:

Kev tsis haum tshuaj (urticaria, angioedema - ua npaws, ua tsis taus pa, ntshav tsawg), lipodystrophy, ua rau muaj qhov tsis zoo ntawm lub sijhawm (feem ntau hauv cov neeg mob uas tsis tau txais insulin yav dhau los), hypoglycemia, hypoglycemic com.

Cov tsos mob: tsaug zog, tawm hws, tawm hws, tawm hws, tsis pom kev, tachycardia, tshee tshee, tshaib plab, ntxhov siab, mob plab nyob rau hauv lub qhov ncauj, pallor ntawm daim tawv nqaij, mob taub hau, tshee tshee, ntuav, tsaug zog, pw tsaug zog, ntshai, ntxhov siab, chim siab, txawv txav, qhov tsis paub tseeb txog kev txav chaw, tsis hnov ​​lus thiab pom lub zeem muag, tsis meej pem, hypoglycemic coma, nriaj. Kev Kho Mob: yog tias tus neeg mob nco qab, dextrose raug kho qhov ncauj, s / c, iv lossis iv txhaj tshuaj glucagon lossis iv hypertonic dextrose tov. Nrog rau kev txhim kho lub ntsej muag tsis nco qab, 20-40 ml (txog 100 ml) ntawm 40% dextrose tov yog txhaj iv rau hauv qhov dej kom txog thaum tus neeg mob tawm ntawm lub cev tsis nco qab.

Muab thiab kev coj:

Cov koob tshuaj tau txiav txim siab ib tus zuj zus nyob ntawm theem ntawm glycemia. Kev sib xyaw 25% insulin lispro thiab 75% kev tiv thaiv tshuaj tiv thaiv yuav tsum tau tsuas yog muab s / c, feem ntau 15 feeb ua ntej noj mov.

Yog tias tsim nyog, koj tuaj yeem nkag mus nrog kev siv tshuaj insulin kom ntev los yog nrog sulfonylureas rau kev tswj hwm qhov ncauj. Kev txhaj tshuaj yuav tsum tau ua s / c hauv lub xub pwg, lub duav, lub duav lossis lub plab.

Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom qhov chaw qub siv tsis ntau tshaj 1 zaug hauv ib hlis. Nrog s / c tswj hwm, kev saib xyuas yuav tsum tau ua kom tsis txhob nkag rau cov ntshav ntshav.

Hauv cov neeg mob lub raum thiab / lossis daim siab ua haujlwm, lub siab ntawm cov ntshav insulin nce ntxiv, thiab qhov xav tau nws tuaj yeem txo qis, uas yuav tsum tau ceev faj soj ntsuam ntawm theem ntawm glycemia thiab koob tshuaj kho mob ntawm insulin.

Cov lus qhia tshwj xeeb:

Cov kev ntawm cov thawj coj tswj hwm rau daim ntawv ntau npaum siv yuav tsum tau nruj siv. Thaum hloov cov neeg mob los ntawm kev ua yeeb yam sai sai ntawm cov tsiaj keeb kwm rau insulin lispro, yuav tsum tau txhaj koob tshuaj.

Kev hloov chaw ntawm cov neeg mob tau txais cov tshuaj insulin nyob rau hauv ib hnub ntau dua 100 units los ntawm ib hom tshuaj insulin rau lwm tus yog pom zoo kom nqa tawm hauv tsev kho mob.

Qhov xav tau ntawm cov tshuaj insulin tuaj yeem nce ntxiv thaum muaj kab mob kis, nrog kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov khoom noj carbohydrates hauv zaub mov, thaum ntxiv kev noj tshuaj ntxiv nrog hyperglycemic kev ua si (cov thyroid hormones, GCS, qhov ncauj tiv thaiv kab mob, thiazide diuretics).

Qhov xav tau ntawm cov tshuaj insulin tuaj yeem txo nrog lub raum thiab / lossis lub siab ua haujlwm, nrog qhov txo qis hauv cov khoom noj hauv cov zaub mov, nrog kev tawm dag zog lub cev, thaum ntxiv kev noj tshuaj nrog hypoglycemic kev ua si (MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides).

Kev ntsuam xyuas kev txhim kho hypoglycemia tuaj yeem cuam tshuam cov peev xwm ntawm cov neeg mob koom rau hauv kev tsav tsheb, nrog rau kev saib xyuas cov tshuab thiab tshuab.

Cov neeg mob ntshav qab zib tuaj yeem nres cov ntshav qabzib uas tau txais los ntawm lawv los ntawm kev noj cov piam thaj lossis zaub mov ntau hauv carbohydrates (Nws raug nquahu kom koj ib txwm muaj tsawg kawg 20 g suab thaj nrog koj). Nws yog ib qho tsim nyog yuav tsum tau qhia rau tus kws kho mob uas tau tuaj kawm txog qhov hloov pauv hypoglycemia txhawm rau daws qhov teeb meem ntawm qhov xav tau ntawm kev kho mob kho. Qhov xav tau rau cov tshuaj insulin feem ntau poob qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce hauv qib thib ob txog rau qib thib peb. Thaum yug menyuam thiab tam sim ntawd tom qab lawv, xav tau cov tshuaj insulin tuaj yeem txo qis.

Tshuaj insulin Lizpro, glycerol, metacresol, zinc oxide, sodium hydrogen phosphate heptahydrate, hydrochloric acid (sodium hydroxide tov), ​​dej.

Kev ntsuas rau siv

Mob ntshav qab zib-insulin raws mellitus: pluag tsis zoo ua rau lwm yam tshuaj insulin, postprandial hyperglycemiame ntsis kho los ntawm lwm yam tshuaj, mob insulin zoo,

Mob ntshav qab zib mellitus: nyob rau hauv kis ntawm tsis kam mus rau tshuaj tiv thaiv kab mob, nrog haujlwm thiab kab mob ua rau chaw kho mob ntshav qab zib.

Cov ntawv qhia ua lus, cov lus qhia rau kev siv

Cov koob tshuaj ntawm cov tshuaj tau teeb tsa ua ib tus zuj zus nyob ntawm qhov rhiab ntawm cov neeg mob mus rau tshuaj exogenous thiab lawv mob. Nws raug nquahu kom tswj cov tshuaj tsis pub dhau 15 feeb ua ntej lossis tom qab noj mov. Cov txheej txheem kev tswj hwm yog tus kheej. Ua li ntawd, tshuaj kub yuav tsum tau nyob theem theem.

Kev ua txhua hnub tuaj yeem sib txawv, muaj ntau qhov ntau rau 0.5-1 IU / kg. Nyob rau yav tom ntej, cov koob tshuaj txhua hnub thiab ib zaug ntawm cov tshuaj tau raug hloov kho nyob ntawm tus neeg mob metabolism thiab cov ntaub ntawv los ntawm ntau cov ntshav thiab cov zis ntsuas cov ntshav qabzib.

Kev tswj hwm kev siv tshuaj ntawm Humalog yog nqa tawm raws li kev txhaj tshuaj rau cov tshuaj tua kabmob. Kev txhaj tshuaj subcutaneous yog tsim nyob rau hauv lub xub pwg, pob tw, ncej puab lossis hauv plab, ntu hloov lawv thiab tsis pub siv qhov chaw ntau tshaj ib hlis ib zaug, thiab qhov chaw txhaj tshuaj yuav tsum tsis txhob muab zaws. Thaum ua cov txheej txheem, yuav tsum tau saib xyuas kom tsis txhob nkag rau hauv cov hlab ntshav.

Tus neeg mob yuav tsum tau kawm cov txheej txheem txhaj tshuaj kom raug.

Kev sib txuam

Kev txo lub plawv tsis zoo ntawm cov tshuaj yog txo qis tshuaj tiv thaiv qhov ncauj, Tshuaj cov thyroid hormones, GKS, Danazole, beta 2-adrenergic agonists, tricyclic cov tshuaj tiv thaiv kev ntxhov siab, tshuaj kho mob, Diazoxide, Isoniazid, Chlorprotixen, lithium carbonatederivatives phenothiazine, nicotinic acid.

Kev txo lub plawv tsis zoo ntawm cov tshuaj yog kho kom zoo anabolic tshuaj yuam, beta blockerstshuaj ethanol-muaj cov tshuaj Fenfluramine, tetracyclines, Guanethidine, MAO inhibitors, tshuaj tiv thaiv qhov ncauj hypoglycemic, salicylates, sulfonamides, ACE inhibitors, Octreotide.

Cov tshuaj tiv thaiv pej xeem tsis pom zoo kom sib xyaw nrog cov tsiaj tshuaj insulin, tab sis nws tuaj yeem raug tshuaj nyob rau hauv kev saib xyuas ntawm kws kho mob nrog kev ua haujlwm ntev ntawm tib neeg.

Halogen nqi, yuav khoom qhov twg

Tus nqi ntawm Humalog 100 IU / ml cartridges 3 ml N5 sib txawv hauv qhov ntau ntawm 1730-2086 rubles rau pob. Koj tuaj yeem yuav cov tshuaj no hauv cov chaw muag tshuaj feem ntau hauv Moscow thiab lwm lub nroog.

• Humalog Sib tov 25 ncua kev kawm 100 IU / ml 3 ml 5 pcs .Li Lilly Eli Lilly & Tuam Txhab
• Qoob loo ncua kev ncua 100 IU / ml 3 ml 5 pcs. Lilly Eli Lilly & Tuam Txhab

• Humalog tov 100ME / ml 3ml Tsis muaj. 5 cartridges
• Humalog Sib tov 25 ncua kev kawm 100ME / ml 3ml No. 5 cartridges

Kws tshuaj IFK

• Insulin Humalog Lilly Fabkis S.A.S., Fabkis
• Insulin Humalog Mix 25 Lilly Fabkis S.A.S., Fabkis
• Insulin Humalog Lilly Fabkis S.A.S., Fabkis

THEM SAIB! Cov ntaub ntawv hais txog cov tshuaj ntawm lub xaib yog kev saib xyuas-dav dav, sau los ntawm pej xeem cov chaw thiab tsis tuaj yeem ua lub hauv paus rau kev txiav txim siab txog kev siv tshuaj hauv kev kho mob.

Ua ntej siv cov tshuaj Humalog, nco ntsoov sab laj nrog koj tus kws kho mob.

Cov Kev Tshaj Tawm ntawm Humalog

Lyspro insulin raws li cov tshuaj nquag muaj tsuas yog nyob hauv thawj phau ntawv teev npe. Cov tshuaj uas ze ze yog NovoRapid (raws li aspart) thiab Apidra (glulisin).

Cov cuab yeej no tseem yog ultra-luv, yog li nws tsis muaj teeb meem twg uas yuav tsum xaiv. Txhua tus tau txais txiaj ntsig zoo thiab muab cov suab thaj txo ntau.

Raws li txoj cai, kev nyiam yog muab rau cov tshuaj, uas tuaj yeem muab pub dawb hauv chaw kho mob.

Qhov kev hloov pauv ntawm Humalog mus rau nws txoj kab ke paum yuav tau tsim nyog muaj kev fab ua txhaum. Yog tias tus mob ntshav qab zib ua raws li cov zaub mov tsis zoo, lossis feem ntau muaj ntshav qab zib hauv lub cev, nws yog qhov muaj kuab siv tib neeg ntau dua li siv cov tshuaj insulin.

Thov nco tseg: Koj puas npau suav kom tshem tawm cov ntshav qab zib ib zaug thiab rau txhua? Kawm yuav ua li cas kom kov yeej cov kabmob, tsis tas siv cov tshuaj uas kim kim, siv xwb ... >> nyeem ntxiv ntawm no

Humalog Mix analogues

Cov lus qhia ntawm kev siv tshuajNeej Neeg Sib

Daim ntawv tso tawm
subcutaneous kev ncua

Muaj pes tsawg leeg
1 ml ntawm kev ncua kev kawm muaj: insulin lyspro 100 IU yog kev sib xyaw: insulin kua lispro 25% kev ncua ntawm insulin lyspro tiv thaiv 75%

Cov kev zam: dibasic sodium phosphate, glycerol (glycerin), kua phenol, metacresol, protamine sulfate, zinc oxide, d / i dej, hydrochloric acid (10% tov) thiab / lossis sodium hydroxide (10% kev daws) (los tsim pH) Cov.

Ntim
5 Cov cwj mem ceev nrawm 3 ml txhua, 5 cartridges 3 ml txhua.

Pharmacological kev txiav txim
Humalog Mix yog qhov tshuaj hypoglycemic, ib qho kev sib xyaw ntawm kev sai thiab nruab nrab ntev insulin analogues.

Humalog Mix 25 yog DNA - muab cov kab mob tshiab ntawm tib neeg cov kua dej thiab yog qhov sib xyaw ua ke uas muaj lyspro insulin tov (kev ua kom sai ntawm tib neeg cov tshuaj insulin) thiab kev ncua ntawm lyspro protamine insulin (nruab nrab ntev tib neeg insulin analogue).

Kev ua tseem ceeb ntawm insulin lyspro yog kev cai ntawm cov metabolism hauv cov piam thaj. Tsis tas li ntawd, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg lub cev.

Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Nws tau qhia tias cov tshuaj insulin lyspro yog qhov sib npaug rau tib neeg cov tshuaj insulin, tab sis nws cov kev nqis tes ua sai dua thiab kav rau lub sijhawm luv. Qhov pib ntawm cov tshuaj yog tom qab kwv yees li 15 feeb, uas tso cai rau nws ua sai sai ua ntej noj mov (0-15 feeb ua ntej noj mov), piv nrog tib neeg cov tshuaj insulin.

Tom qab s / c txhaj tshuaj ntawm Humalog Mix 25, qhov pib sai ntawm qhov kev nqis tes ua thiab qhov siab tshaj plaws thaum ntxov hauv lyspro insulin kev ua ub no raug pom. Kev txiav txim siab profile ntawm insulin lysproprotamine zoo ib yam li cov yeeb yam kev sib piv ntawm cov insulin isophan uas ib txwm siv ntev li 15 teev.

Humalog Mix 25, qhia txog kev siv
Ntshav qab zib mellitus xav tau kev kho mob insulin.

Cov Yuav Tsum Muaj
Cov tshuaj tiv thaiv ntshav qab zib tsawg, ua rau lub cev tsis sib haum ntawm cov tshuaj.

Tsuas tshuaj thiab tswj hwm
Tus kws kho mob txiav txim siab muab koob tshuaj ib leeg zuj zus, nyob ntawm seb muaj ntshav qabzib nyob hauv cov ntshav. Qhov tseeb ntawm kev muab tshuaj insulin yog tus kheej.

Cov tshuaj yuav tsum tau muab s / c. Hauv / hauv kev qhia ntawm cov tshuaj Humalog® Mix 25 yog sib kis. Qhov ntsuas kub ntawm cov tshuaj yuav tsum sib haum rau chav tsev kub. SC yuav tsum muab rau lub xub pwg, ncej puab, pob tw, lossis plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj 1 zaug hauv ib hlis.

Thaum tswj hwm qhov Humalog® kev npaj s / c, yuav tsum tau saib xyuas kom tiv thaiv cov tshuaj los rau hauv cov hlab ntshav. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob siv ntau dhau los.Thaum txhim kho daim cartridge rau hauv cov twj txhaj tshuaj insulin thiab txuas lub koob, lub tuam txhab cov lus qhia rau kev tswj hwm tshuaj insulin

Sab sij huam

Ib qhov kev cuam tshuam nrog cuam tshuam nrog lub ntsiab cuam tshuam ntawm cov tshuaj: feem ntau ntau - hypoglycemia. Kev mob ntshav qis heev tuaj yeem ua rau tsis nco qab thiab, tshwj tsis yog, tuag taus.

Ua xua: qhov kev tawm tsam ntawm lub zos yog muaj peev xwm ua tau - liab, o lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau ploj hauv ob peb hnub lossis ob peb lim tiam, qee qhov, cov kev coj ua no tshwm sim los ntawm cov laj thawj tsis cuam tshuam rau cov tshuaj insulin, piv txwv li, tawv nqaij los ntawm kev siv tshuaj tiv thaiv kab mob los yog kev txhaj tshuaj tsis raug ), cov kev tsis haum rau lub cev (tshwm sim tsawg dua, tab sis muaj qhov hnyav dua) - ua kom khaus, ua tsis taus pa, txog siav, txo ntshav siab, tachycardia, tawm hws. Muaj qee zaus muaj kev sib tim tsis haum hnyav tuaj yeem ua rau tuag taus tau. Thaum muaj qhov tsis haum txaus ntshai heev rau Humalog Mix 25, yuav tsum tau kho tam sim. Tej zaum yuav xav tau pauv ntshav insulin, lossis desensitization.Qhov cov tshuaj tiv thaiv hauv zos: nrog rau siv ntev, lipodystrophy yuav tsim nyob ntawm qhov chaw txhaj tshuaj.

Cov lus qhia tshwj xeeb
Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis kev npaj tshuaj insulin nrog lub lag luam sib txawv yuav tsum tshwm sim nyob rau hauv kev saib xyuas mob nkeeg nruj. Cov kev hloov hauv kev ua, hom (tsim tawm), hom (xws li tsis tu ncua, NPH), hom (tsiaj, tib neeg, tib neeg insulin analogue) thiab / lossis txoj kev tsim tawm (DNA recombinant insulin lossis tsiaj insulin) tej zaum yuav xav tau kev hloov kho koob tshuaj Cov.

Rau qee tus neeg mob, yuav tau kho kom tau cov koob tshuaj thaum hloov los ntawm tsiaj los ntawm insulin los rau tib neeg insulin. Qhov no tuaj yeem tshwm sim twb tau dhau los ntawm thawj zaug kev tswj hwm ntawm tib neeg li kev npaj tshuaj insulin lossis maj mam li ntawm ob peb lub lis piam lossis hli tom qab hloov mus.

Cov tsos mob ua ntej ntawm hypoglycemia thaum tswj hwm ntawm tib neeg cov tshuaj insulin hauv qee cov neeg mob yuav tsis tshua pom los yog txawv ntawm cov uas tau soj ntsuam nrog kev tswj hwm ntawm insulin ntawm tsiaj keeb kwm.

Nrog kev ua haujlwm ntawm cov ntshav qabzib hauv lub cev, piv txwv li, los ntawm kev kho mob insulin ntau dua, txhua yam lossis qee tus tsos mob ntawm cov xwm txheej ua ntej ntawm hypoglycemia yuav ploj, txog qhov uas cov neeg mob yuav tsum tau ceeb toom.

Cov tsos mob ua ntej ntawm lub ntsej muag hypoglycemia tuaj yeem hloov lossis tsis tau hais tawm nrog lub sijhawm ntev ntawm mob ntshav qab zib mellitus, mob ntshav qab zib neuropathy lossis kev kho mob nrog tshuaj xws li beta-blockers.

Kev noj tshuaj tsis txaus lossis tsis ua haujlwm ntawm kev kho mob, tshwj xeeb tshaj yog nyob rau cov neeg mob insulin-tiv thaiv cov ntshav qab zib mellitus, tuaj yeem ua rau hyperglycemia thiab mob ntshav qab zib ketoacidosis (mob uas yuav tsim kev puas tsuaj rau tus neeg mob lub neej). Cov.

Nrog rau qee cov kabmob lossis nrog kev ntxhov siab hauv lub siab, qhov xav tau cov tshuaj insulin yuav nce. Kev kho ntawm cov koob tshuaj insulin kuj tseem xav tau nrog kev nce ntxiv hauv kev ua haujlwm lossis nrog kev hloov pauv ntawm ib txwm noj zaub mov.

Yeeb tshuaj sib cuam tshuam
Qhov ua rau lub ntsej muag hypoglycemic ntawm cov tshuaj Humalog Mix 25 txo nrog cov kev sib xyaw ua ke ntawm cov tshuaj hauv qab no: tshuaj tiv thaiv qhov ncauj, corticosteroids, thyroid hormone npaj, danazole, beta2-adrenergic agonists (incl.ritodrin, salbutamol, terbutaline), thiazide diuretics, lithium npaj, chlorprotixen, diazoxide, isoniazid, nicotinic acid, phenothiazine derivatives.

Cov nyhuv hypoglycemic ntawm Humalog Mix 25 yog txhim kho los ntawm beta-blockers, ethanol thiab ethanol-muaj cov tshuaj, anabolic steroids, fenfluramine, guanethidine, tetracyclines, tshuaj tiv thaiv hypoglycemic, salicylates (piv txwv li, acetylsalicylic acid, inhibitors, capri inhibitors, inhibitors) Beta-blockers, clonidine, reserpine tuaj yeem npog qhov pom ntawm cov tsos mob ntawm cov ntshav qog ntshav qab zib. insulin tsis tau kawm.

Noj ntau dhau
Cov tsos mob: hypoglycemia, nrog rau cov tsos mob li nram no - qaug zog, tawm hws ntau, mob tachycardia, mob taub hau, ntuav, tsis meej pem. Hauv qee qhov xwm txheej, piv txwv li, nrog lub sijhawm ntev lossis nrog kev soj ntsuam mob ntshav qab zib mellitus, cov tsos mob ua ntej ntawm cov ntshav qog ntshav qab zib tuaj yeem hloov pauv.

Kev Kho Mob: Cov mob ntshav qab zib tsawg kawg feem ntau yuav nres los ntawm kev noj cov piam thaj lossis lwm yam piam thaj, lossis cov khoom muaj suab thaj. Yuav tsum tau txhaj koob tshuaj insulin, noj zaub mov, lossis ua kom lub cev qoj ib ce.

Kev kho cov ntshav qog ntshav me ntsis tuaj yeem nqa tawm nrog kev pab ntawm a / m lossis s / c tswj hwm ntawm glucagon, tom qab los ntawm kev noj zaub mov carbohydrates.

Cov mob ntshav qog ntshav siab, nrog rau kev tsis nco qab, ua kom mob hlwb lossis mob hlwb, tau nres hauv / m lossis s / c los ntawm kev qhia ntawm glucagon lossis iv los ntawm kev qhia txog kev daws teeb meem ntawm cov tshuaj tov ntawm dextrose (qabzib).

Tom qab nws rov qab nco qab, tus neeg mob yuav tsum tau txais cov khoom noj uas yog carbohydrate kom tiv thaiv qhov rov qab txhim kho ntshav qab zib. Nws yuav tsum tau txais kev noj haus ntxiv ntawm carbohydrates thiab kuaj neeg mob. Ib qho kev rov qab los ntawm hypoglycemia yog ua tau.

Cia rau cov neeg mob
Hauv qhov chaw tsaus ntawm qhov kub ntawm 2-8 ° C.

Hnub tas sij hawm
2 xyoos

Cov yam ntxwv thiab cov lus qhia rau kev siv insulin Humalog

Ntawm cov tshuaj feem ntau siv cov tshuaj insulin tuaj yeem hu ua Humalog. Cov tshuaj kho tau raug tsim tawm hauv Switzerland.

Nws yog ua raws li insulin Lizpro thiab npaj rau kev kho mob ntshav qab zib.

Cov tshuaj yuav tsum yog tus kws kho mob sau tseg. Nws kuj yuav tsum piav qhia txoj cai tswj kev noj tshuaj txhawm rau kom zam dhau lub txim tsis zoo. Cov tshuaj yuav muag los ntawm cov tshuaj nkaus xwb.

Humalog yog nyob rau hauv daim ntawv ntawm ncua kev kawm lossis kev txhaj tshuaj. Kev raug tshem tawm yog txais tos nyob rau hauv cov neeg dawb thiab ib qho nyiam nyiam lub siab. Txoj kev daws teeb meem tsis muaj xim thiab tsis ntxhiab, pob tshab.

Qhov tseem ceeb ntawm cov khoom muaj pes tsawg leeg yog Lizpro insulin.

Ntxiv rau nws, cov khoom xyaw xws li:

• dej
• metacresol
• zinc oxide
• glycerol
• sodium hydrogen phosphate heptahydrate,
• Cov kua sodium hydroxide.

Cov khoom lag luam raug muag hauv 3 ml cartridges. Cov ntawv thawv yog nyob hauv Quickpen syringe mem, 5 daim ib pob.

Tsis tas li ntawd, muaj ntau yam yeeb tshuaj, uas suav nrog kev hais luv luv ntawm cov tshuaj insulin thiab kev txwv tsis pub tshuaj. Lawv hu ua Humalog Mix 25 thiab Humalog Mix 50.

Lizpro insulin yog ib qho tshuaj tiv thaiv ntawm tib neeg cov tshuaj insulin thiab yog tus cwj pwm zoo tib yam. Nws pab txhawm rau ua kom nce tus nqi ntawm cov piam thaj. Cov tshuaj ua yeeb yaj kiab ua haujlwm ntawm lub cell cell, vim tias cov piam thaj hauv cov ntshav nkag mus rau cov ntaub so ntswg thiab muab faib rau hauv lawv. Nws kuj txhawb nqa ua kom cov protein ua haujlwm zoo.

Cov tshuaj no yog tus cwj pwm los ntawm kev ua sai. Cov nyhuv tshwm nyob rau hauv ib lub hlis twg ntawm ib teev tom qab txhaj tshuaj. Tab sis nws mob tsawv rau ib pliag. Rau ib nrab-lub neej ntawm cov tshuaj yeeb yaj kiab, li 2 teev xav tau. Qhov siab tshaj plaws rau lub sijhawm yog 5 teev, uas cuam tshuam los ntawm qee qhov yam ntxwv ntawm tus neeg mob lub cev.

Kev taw qhia thiab contraindications

Qhov taw qhia rau kev siv cov tshuaj insulin-muaj yog:

Hauv cov xwm txheej no, yuav tsum tau kho cov tshuaj insulin. Tab sis tib lub Humalog yuav tsum tau tsa los ntawm tus kws kho mob tom qab kawm txog daim duab ntawm tus kab mob. Cov tshuaj no muaj qee yam contraindications. Koj yuav tsum xyuas kom meej tias lawv tsis tuaj, txwv tsis pub muaj kev pheej hmoo ntawm cov kev mob tshwm sim.

Cov no suav nrog:

• kev tshwm sim ntawm kev ua qog hypoglycemia (lossis qhov tshwm sim ntawm nws qhov tshwm sim),
• fab rau cov muaj pes tsawg leeg.

Nrog rau cov ntsej muag no, tus kws kho mob yuav tsum xaiv lwm yam tshuaj sib txawv. Ceev faj kuj tseem ceeb yog tias tus neeg mob muaj qee cov kab mob ntxiv (kab mob ntawm lub siab thiab lub raum), vim tias vim lawv, lub cev xav tau cov tshuaj insulin tuaj yeem ua kom tsis muaj zog. Raws li, cov neeg mob zoo li no yuav tsum kho cov tshuaj ntau ntxiv.

Cov Neeg Mob Tshwj Xeeb thiab Cov Lus Qhia

Thaum siv Humalog, qee qhov yuav tsum tau ceev faj txog qhov tshwj xeeb ntawm cov neeg mob. Lawv lub cev yuav nkag siab dhau los cuam tshuam txog cov tshuaj insulin, yog li koj yuav tsum tau ua tib zoo saib xyuas.

Ntawm lawv yog:

1. Cov poj niam thaum cev xeeb tub. Raws txoj kev xav, kev kho mob ntshav qab zib hauv cov neeg mob no tau tso cai. Raws li kev tshawb pom, cov tshuaj tsis cuam tshuam rau kev txhim kho ntawm tus me nyuam hauv plab thiab tsis ua rau muaj kev rho menyuam hauv plab. Tab sis nws yuav tsum tau yug los rau hauv lub siab tias lub sijhawm no cov theem ntawm cov piam thaj hauv cov ntshav tuaj yeem sib txawv ntawm cov sijhawm sib txawv. Qhov no yuav tsum raug tswj kom tsis txhob muaj qhov tsis xav ua yam tsis zoo.
2. Saib xyuas niam cov txiv. Kev nkag mus ntawm cov tshuaj insulin rau hauv niam mis tsis yog qhov kev phom sij rau tus menyuam mos. Qhov khoom siv no muaj cov keeb kwm protein thiab nqus tau ntawm txoj hnyuv zom zaub mov. Qhov ceeb toom tsuas yog tias cov poj niam uas ua raws li kev noj zaub mov zoo yuav tsum yog nyob ntawm zaub mov noj.

Rau cov menyuam yaus thiab cov laus hauv qhov tsis muaj teeb meem kev noj qab haus huv, tsis muaj kev saib xyuas tshwj xeeb. Cov tshuaj Humalog yog qhov haum rau lawv txoj kev kho mob, thiab tus kws kho mob yuav tsum xaiv qhov ntau npaum li cas los ntawm cov yam ntxwv ntawm chav kawm ntawm tus kabmob.

Kev siv ntawm Humalog yuav tsum muaj qee qhov kev xav hauv kev sib raug rau qee yam kabmob sib kis.

Cov no suav nrog:

1. Kev ua txhaum nyob rau hauv daim siab. Yog tias qhov kev ua haujlwm ntawm lub cev ua haujlwm tsis zoo tshaj li qhov tsim nyog, tom qab ntawd cov nyhuv ntawm cov tshuaj rau nws yuav dhau mus, uas ua rau muaj teeb meem, nrog rau kev txhim kho hypoglycemia. Yog li ntawd, nyob rau hauv qhov muaj kab mob siab, qhov kev noj tshuaj ntawm Humalog yuav tsum raug txo kom tsawg.
2. Teeb meem lub raum ua haujlwm. Yog tias lawv nyob hauv, nws tseem muaj qhov txo qis hauv lub cev xav tau cov tshuaj insulin. Hauv kev hais txog qhov no, koj yuav tsum ua tib zoo suav seb puas noj ntau npaum li cas thiab saib xyuas txoj kev kho. Lub xub ntiag ntawm cov teeb meem zoo li no yuav tsum muaj kev tshuaj xyuas lub raum ib qho zuj zus.

Humalog muaj peev xwm ua rau cov ntshav qis, vim tias qhov ceev ntawm cov tshuaj tiv thaiv thiab lub peev xwm mloog zoo yog cuam tshuam.

Kiv taub hau, tsis muaj zog, tsis meej pem - tag nrho cov yam ntxwv no tuaj yeem cuam tshuam kev ua haujlwm ntawm tus neeg mob. Kev ua ub no uas xav tau kev nrawm thiab kev xav yuav ua tsis tau rau nws. Tab sis cov tshuaj nws tus kheej tsis cuam tshuam rau cov ntsej muag no.

Nqi, tshuaj xyuas thiab analogues tshuaj

Cov tshuaj yuav muag los ntawm cov tshuaj nkaus xwb. Nws tuaj yeem muas ntawm chaw muag tshuaj lossis chaw muag tshuaj online. Tus nqi ntawm cov tshuaj los ntawm Humalog series tsis yog ntau heev, txhua tus neeg nrog cov nyiaj tau los nruab nrab tuaj yeem yuav nws. Tus nqi ntawm kev npaj tau yog rau Humalog Mix 25 (3 ml, 5 pcs) - los ntawm 1790 txog 2050 rubles, thiab rau Humalog Mix 50 (3 ml, 5 pcs) - los ntawm 1890 txog 2100 rubles.

Kev txheeb xyuas ntawm cov neeg mob ntshav qab zib feem ntau txog insulin Humalog zoo. Muaj ntau cov lus pom nyob hauv Is Taws Nem txog kev siv tshuaj, uas tau hais tias nws yooj yim siv, thiab nws ua sai sai.

Cov kev mob tshwm sim muaj tsawg heev. Tus nqi ntawm cov tshuaj yog tsis dhau "tom", raws li tau thov los ntawm cov ntshav qab zib tau. Insulin Humalog ua haujlwm zoo heev uas muaj ntshav qab zib ntau ntau.

Ntxiv rau, qhov zoo hauv qab no ntawm cov tshuaj los ntawm cov koob no tuaj yeem ua qhov txawv:

• paub metabolism hauv carbohydrate,
• txo hauv HbA1,
• txo ntawm glycemic tawm tsam nruab hnub thiab hmo ntuj,
• muaj peev xwm siv khoom noj yooj yim,
• yooj yim ntawm kev siv tshuaj.

Hauv qhov xwm txheej uas tus neeg mob txwv tsis pub siv cov tshuaj los ntawm koob tshuaj Humalog, tus kws kho mob tuaj yeem sau ib qho ntawm cov tshuaj zoo ib yam, piv txwv li:

1. Isofan
2. Iletin
3. Pensulin,
4. Qov tshuaj insulin C,
5. Cov tshuaj insulin,
6. Rinsulin
7. Actrapid MS thiab lwm tus.

Cov tshuaj ib txwm muaj niaj hnub hloov zuj zus, tsim kho thiab txhim kho cov tshuaj uas pab ntau tus neeg los tswj kev ua neej thiab kev noj qab haus huv.

Nrog rau kev siv tshuaj insulin kom zoo los ntawm Humalog cov tshuaj, koj tuaj yeem tshem tawm qhov kev tawm tsam uas mob ntshav qab zib tsawg thiab cov tsos mob ntawm "mob qab zib". Koj yuav tsum ua raws li cov lus pom zoo los ntawm koj tus kws kho mob thiab tsis txhob noj tshuaj rau tus kheej.

Tsuas yog hauv txoj kev no ib tus neeg uas muaj kev mob ntshav qab zib tuaj yeem tswj hwm tus kab mob thiab muaj txoj sia nyob nrog tus neeg muaj mob.

Cov yeeb yaj kiab hauv tsab xov xwm no yuav qhia txog cov ntsej muag pharmacological ntawm cov tshuaj insulin.

Qhia koj qab zib lossis xaiv tus tub los ntxhais rau cov lus pom zoo Nrhiav. Nrhiav tsis pom. Tshawb pom. Nrhiav tsis pom. Pom. Nrhiav tsis pom.