Dab tsi tuaj yeem npaj los ntawm squid: ceev thiab qab

Metformin yog cov tshuaj kho mob ntshav qab zib tshaj plaws rau cov ntshav qab zib. Ntxiv rau, nws yog siv los tawm tsam kev rog thiab kom tshem tau polycystic ovary hauv gynecology. Cov tshuaj tso cai rau koj kom tshem tawm ntau tshaj qhov hnyav, txo qis ntawm theem, tab sis tsis ua rau muaj kev phiv loj heev.

Kev noj tshuaj Metformin yog ib txoj kev tiv thaiv zoo rau kev txhim kho kev mob ntshav qab zib hnyav, xws li mob plawv nres thiab mob hlab ntsha hlwb, thiaj li ua rau lub neej ntev dua ntawm cov neeg mob. Muaj cov ntaub ntawv pov thawj tias Metformin tiv thaiv tib neeg los ntawm qee yam qog hlav qog ntshav.

Tus nqi ntawm cov tshuaj yog tsawg, vim tias ntau lub tuam txhab ua lag luam koom nrog nws cov khoom lag luam.

Cov lus qhia rau noj Metformin, uas tau hais hauv cov lus qhia ntawm nom:

Mob ntshav qab zib Hom 2.

Yam 1 ntshav qab zib mellitus hauv cov neeg mob rog rog thiab insulin tsis kam.

Txawm li cas los xij, hauv kev muaj tiag, ntau tus neeg siv Metformin kom poob ceeb thawj. Nws kuj tseem raug kho rau kev kho mob polycystic ovary syndrome hauv cov poj niam. Qhov kev ntsuas no nce siab rau tus neeg mob txoj kev muaj lub siab zoo.

Ntxiv nrog rau kev noj tshuaj, cov poj niam uas muaj mob polycystic ovary syndrome yuav tsum ua raws li kev noj haus kom tsawg thiab ua kom ib ce muaj zog. Qhov no ua rau kom muaj kev pheej hmoo zoo.

Metformin: cov lus qhia rau kev siv

Cov tshuaj ua haujlwm li cas?

Metformin tau raug tshuaj rau kev mob ntshav qab zib mellitus ntawm yam thib ob, thiab qee zaum hauv kev kho mob sib xyaw ua ke rau hom ntshav qab zib hom 1. Cov tshuaj yuav pab txo cov ntshav qab zib ob qho tib si rau ntawm lub plab khoob thiab tom qab noj mov, thiab tseem tso cai rau koj kom ib txwm muaj qib glycated hemoglobin.
Kev noj cov tshuaj ua rau nws tuaj yeem txo cov piam thaj hauv kev ua haujlwm hauv lub siab, thiab tseem tiv thaiv ntau dhau ntawm kev nqus ntawm carbohydrates hauv txoj hnyuv. Ua tsaug rau Metformin, nws muaj peev xwm nce qhov rhiab heev ntawm cov hlwb rau cov tshuaj insulin. Lub txiav ua kab mob thaum kho tsis tuaj yeem tsim cov insulin ntau dhau, uas tiv thaiv kom tsis txhob muaj qog ntshav qab zib.

Cov tshuaj tsis nthuav tawm hauv lub cev. Feem ntau ntawm nws yog tawm los ntawm lub raum. Thaum siv cov tshuaj ntev dua los siv, piv txwv li, Glucofage Ntev, Metformin yog nqus tau ntev dua yog tias koj piv lub sijhawm no nrog kev noj cov tshuaj tsis tu ncua.
Qhia rau kom paub tias ib tug neeg raug kev txom nyem los ntawm qee yam kab mob hauv lub raum, Metformin yuav tsum tau siv nrog ceeb toom.

Thaum twg mam coj

Cov tshuaj yog tawm rau cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, cov tib neeg muaj rog rog thiab muaj tsawg cov cell ua rau cov insulin.
Kev kho mob nrog metformin yuav tsum tshwm sim tawm tsam ntawm qhov kev qoj ib ce txaus thiab nrog rau kev noj zaub mov kom tsawg.

Thaum cov tshuaj tsis tuaj yeem noj

Cov tshuaj tiv thaiv kev kho mob nrog Metformin:

Ntshav qab zib ketoacidosis.
Mob qab zib coma.
nrog glomerular infiltration tus nqi ntawm 45 ml / min thiab hauv qab.
Qeb ntshav creatinine yog 132 μmol / L rau txiv neej thiab 141 μmol / L rau poj niam.
Daim siab ua haujlwm.
Kev kis tus kab mob hauv cov theem mob ceev.
Lub cev qhuav dej

Dab tsi koj yuav tsum them nyiaj tshwj xeeb rau

Yog tias tus neeg mob yuav tau phais, lossis xoo hluav taws xob los siv kev sib piv, ces nws yuav tsum tsis txhob noj cov tshuaj Metformin 2 hnub ua ntej kev kho mob.
Qee zaum cov neeg mob tuaj yeem tsim cov kev mob hnyav hnyav uas yog cov kab mob lactic acidosis. Qhov no yog nrog nrog txo qis pH hauv ntshav mus rau 7.25, uas ua rau muaj kev hem thawj tsis tsuas yog ua rau muaj kev noj qab haus huv thiab lub neej. Yog li no, thaum pom cov tsos mob xws li mob plab, ua kom tsis muaj zog, ntuav thiab ua pa luv, yuav tsum hu rau lub tsheb thauj neeg mob.
Raws li txoj cai, lactic acidosis kev loj hlob tsuas yog thaum ib tus neeg tau noj ntau dhau lawm ntawm cov tshuaj, lossis kev kho mob tau ua yog tias muaj contraindications. Hauv lwm qhov xwm txheej, Kev Siv Tshuaj Metformin tsis ua rau kev txhim kho ntawm cov kab mob lactic acidosis.

Yuav noj li cas thiab noj li cas

Txoj kev kho yuav tsum pib nrog ib koob tshuaj 500-850 mg ib hnub twg. Maj mam, nws tau nce siab thiab nqa ntau txog 2550 mg rau ib hnub, noj 1 lub tshuaj ntawm 850 mg peb zaug ib hnub. Qhov nce yuav tsum tshwm sim 1 zaug hauv 7-10 hnub.
Yog tias ib tus neeg siv tshuaj nrog qhov ua ntev ntev rau kev kho mob, qhov tshuaj txhua hnub raug txo kom qis dua 2000 mg. Siv cov tshuaj 1 zaug hauv ib hnub, thaum mus pw.

Cov kev mob tshwm sim qhia nyob rau hauv daim ntawv tsis sib haum xeeb hauv kev ua haujlwm ntawm lub plab zom mov. Ib tus neeg yuav raug mob raws plab, xeev siab, ntuav, nws qab los noj mov hloov zuj zus, nws txoj kev saj yuav cuam tshuam. Raws li txoj cai, qhov tsis xis nyob yog pom tsuas yog hauv thawj hnub txij li pib kho.
Txhawm rau kom txo qhov zoo li ntawm cov kev mob tshwm sim rau qhov tsawg kawg, kev kho yuav tsum tau pib nrog kev txhaj tshuaj tsawg kawg.
Yog hais tias tus neeg mob muaj pob khaus tawv nqaij thiab khaus, ces qhov no yuav tsum tau txais tswv yim kho mob, vim tias nws yuav qhia tau tias ib tug neeg tsis qaug rau cov tshuaj.
Thaum lub sij hawm ntev kev kho mob, qhov tsis muaj peev xwm ntawm cov vitamin B12 hauv lub cev yog qhov ua tau.

Lactation thiab cev xeeb tub

Thaum xeeb menyuam thiab thaum pub niam mis, cov tshuaj tsis raug cai rau cov pojniam. Txawm li cas los xij, nws feem ntau siv los kho polycystic ovary syndrome. Yog nyob rau lub sijhawm no tus pojniam tau xeeb tub, ces tsis muaj ib yam dabtsi txaus ntshai yuav tshwm sim. Nws yuav tsum tsis lees noj tshuaj tom qab nws pom ntawm nws qhov xwm txheej.

Yog tias loj npaum li cas tau noj

Nrog kev siv tshuaj ntau dhau, hypoglycemia tsis tshwm sim, tab sis cov kab mob lactic acid tuaj yeem tshwm sim (hauv kwv yees li 32% ntawm cov neeg mob). Tus neeg yuav tsum tau mus pw hauv tsev kho mob ceev. Txhawm rau tshem tawm cov tshuaj ntawm lub cev, yuav tsum lim ntshav yog qhov yuav tsum tau ua. Nyob rau hauv parallel, kev tshwm sim kev kho mob yog ua.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog rau kev tswj hwm ib txhij ntawm Metformin nrog cov tshuaj insulin, cov ntshav qab zib kom tsawg yog tau. Tsis tas li, cov tshuaj muaj peev xwm tig tau nrog cov tshuaj txo qis ntshav siab thiab nrog tshuaj rau kev kho mob.

Tso tawm daim ntawv, chaw cia khoom

Cov tshuaj muaj peev xwm nrhiav tau nyob hauv qhov ntau ntawm 500, 850 thiab 1000 mg. Nws muaj nyob hauv ntsiav tshuaj daim ntawv.
Qhov kub ntawm huab cua yuav tsum tsis pub tshaj 25 degrees. Txee lub neej nws txawv ntawm 3 txog 5 xyoos.

Ntshav Qab Zib thiab Metformin

Metformin tuaj yeem noj rau cov neeg mob ntshav qab zib rog. Qhov no yuav txo qhov feem ntau ntawm kev tsim hom ntshav qab zib 2.

Ua ntej koj yuav tsum tau sim ua kom poob phaus nrog zaub mov noj. Yog tias cov nyhuv tsis tiav, tom qab ntawd koj tuaj yeem txuas cov tshuaj. Ntxiv rau kev noj zaub mov noj, ib tus neeg xav tau nce nws lub cev kev ua si: kom koom nrog kev tawm dag zog lub cev, taug kev ntau dua, khiav. Nyob rau hauv tib si, nws yog ib qhov tsim nyog los saib xyuas qib ntawm cov ntshav siab, nrog rau cov qib ntawm cov piam thaj hauv cov ntshav, suav nrog kev yoo mov.

Metformin tsis yog daim ntawv yuav tshuaj. Nws noj thoob plaws lub neej, tsis muaj kev cuam tshuam, txhua hnub.

Yog tias ib tus neeg ua mob raws plab los yog mob plab zom zaub mov tshwm sim, tom qab ntawv qhov no tsis yog qhov laj thawj uas yuav tsum tau kho. Nws yog qhov tau hais tias koj xav tau kom txo tau cov tshuaj rau lub sijhawm.

Txhua 6 lub hlis ib zaug, kev kuaj ntshav yuav tsum ua raws li kev txiav txim siab cov vitamin B12 hauv lub cev. Yog tias muaj qhov tsis muaj peev xwm, ces nws yuav tsum muab cais nyias. Kuj tseem pom zoo kom noj cov vitamins B12 ua kev tiv thaiv kev tiv thaiv.

Kev Noj Qab Haus Huv thiab Metformin

Txhawm rau kom tshem tawm cov phaus ntau dhau lawm, nrog rau kev kho mob ntshav qab zib, koj yuav tsum ua raws li cov zaub mov muaj protein tsawg.Nws tsis txaus ntseeg tsuas yog txiav tawm cov ntsiab lus ntawm cov calories kom txhua hnub thiab qhov muaj roj ntau ntau - qhov no yuav tsis cia koj tswj cov suab thaj kom tswj. Ntxiv mus, kev noj zaub mov kom tsis muaj calorie pab ua kom qab los noj mov, uas yuav ua rau muaj kev ntxhov siab, ua kom tawg thiab lub cev hnyav.

Yog tias koj tsis txo tus nqi ntawm cov carbohydrates noj, ces koj yuav tsis muaj peev xwm ua tiav qhov kev kho mob los ntawm kev noj tshuaj thiab txawm tias muaj cov tshuaj insulin. Noj cov khoom noj zoo yuav ua rau koj muaj txiaj ntsig thiab tiv thaiv kev rog.

Yam tshuaj twg xaiv: Metformin, Siofor lossis Glucofage?

Glucophage yog thawj cov tshuaj raws li metformin. Siofor thiab lwm yam tshuaj yog nws cov analogues.

Glucophage Ntev - lub cuab yeej nrog cov nyhuv ntev. Nws cov thawj coj yog qhov tsawg dua los ua rau kev loj hlob ntawm qhov tshwm sim tsis zoo hauv cov qauv ntawm kev zawv plab dua li cov tshuaj raws li metformin. Glucophage Ntev ntev npaum li cas ua ntej mus pw, uas yuav tiv thaiv cov ntshav qab zib kom sawv ntxov.

Tus nqi ntawm Glucofage thiab Glucophage Kev npaj ntev tsis siab. Yog li ntawd, nws tsis paub hloov mus rau lawv cov analogues. Kev txuag nyiaj tseem ceeb yuav tsis tiav.

Pa ntev metformin thiab metformin - qhov txawv yog dab tsi?

Yog tias ib tug neeg noj tshuaj metformin tsis tu ncua, cov tshuaj yuav nqus sai heev. Tom qab 4 teev tom qab nws tau txais hauv cov ntshav, qhov siab tshaj plaws ntawm cov tshuaj tseem ceeb tau pom muaj. Qhia cov tshuaj 3 zaug hauv ib hnub nrog zaub mov.

Thaum ib tug neeg siv sijhawm ntev-tso tawm metformin, cov tshuaj yuav nqus tau ntev dua, tab sis nws yuav siv sijhawm ntev dua. Qhia cov tshuaj no 1 zaug hauv ib hnub, ua ntej yuav mus pw. Qhov no yuav tiv thaiv kom cov ntshav qab zib ntau ntxiv thaum sawv ntxov.

Ntev ntev metformin tsis tshua muaj kev phiv ua rau txoj kev ua txhaum nyob rau hauv kev ua haujlwm ntawm lub plab zom mov. Txawm li cas los xij, nws tswj cov qib qab zib zuj zus thaum nruab hnub. Yog li, nws raug nquahu kom txais mus kawm rau cov neeg uas muaj ntshav qabzib ntau dua. Cov tshuaj qub ntawm metformin yog Glucofage Ntev. Ntawm kev muag kuj tseem muaj cov yeeb yaj kiab ntawm cov tshuaj no nrog lub sijhawm ntev.

Cov nyhuv ntawm metformin rau daim siab. Rog ua rau hepatosis thiab metformin

Metformin yuav tsum tsis txhob noj nrog lub siab ua rau mob siab, piv txwv li, nrog mob qog lossis daim siab. Nrog rau daim siab ua rog hepatosis, nws txoj kev siv, ntawm qhov tsis sib xws, yuav coj tau cov txiaj ntsig tseem ceeb. Ib qho ntxiv, tus neeg mob yuav tsum ua raws li cov zaub mov uas tsis muaj carbohydrate tsawg. Yog tias koj ua raws li cov lus qhia no, koj yuav ua tau sai sai txhim kho lawv tus kheej kev noj qab haus huv. Kev ua rog rog tuaj yeem dhau ntawm cov khoom noj muaj txiaj ntsig thiab Metformin. Hauv kev sib txuam, ib tus neeg yuav pib poob ceeb thawj.

Metformin thiab cov tshuaj hormones

Metformin tsis cuam tshuam rau txiv neej potency thiab ntshav testosterone qib.

Nrog polycystic ovary syndrome nyob rau hauv cov poj niam, qib siab ntawm txiv neej poj niam txiv neej cov tshuaj tiv thaiv tau raug kuaj, nrog rau kev cuam tshuam ntawm metabolic thiab insulin tsis kam. Noj tshuaj metformin, piv txwv li, Siofor, yuav tshem tawm qhov teeb meem uas twb muaj lawm. Cov tshuaj pab ua rau cov poj niam keeb kwm yav dhau los ua poj niam thiab nce qhov zoo ntawm qhov muaj menyuam.

Yuav siv cov tshuaj dab tsi hloov cov metformin rau lub raum tsis ua hauj lwm?

Noj tshuaj Metformin rau lub raum tsis ua haujlwm yog txwv tsis pub. Nws tsis yog cov tshuaj rau cov neeg mob ntshav qab zib uas qhov glomerular infiltration tus nqi txo mus rau 45 ml / feeb.

Nrog kev mob raum tsis ua haujlwm, koj tuaj yeem noj tshuaj xws li Januvia, Galvus, Glyrenorm. Cov lus qhia ntawm kev siv tshuaj insulin kuj tseem muaj peev xwm ua tau. Nyob rau hauv txhua rooj plaub, tsuas yog tus kws kho mob yuav tsum sau ntawv kho rau cov neeg mob uas muaj cov teeb meem no.

Metformin prolongs lub neej - yog li ntawd?

Metformin qhia meej meej txhawb kom ntev dua ntawm lub neej hauv cov neeg muaj kev mob ntshav qab zib, vim nws txwv tsis pub muaj kev loj hlob ntawm tus mob hnyav.

Raws li rau kev nce hauv lub neej nyob hauv cov neeg mob uas tsis mob ntshav qab zib, tsis muaj pov thawj tshawb fawb txog qhov tseeb no. Txawm li cas los xij, kev tshawb fawb txog cov teeb meem no twb tau pib ua haujlwm.

Koj tseem tuaj yeem pom kev tshuaj xyuas uas kho nrog Glucofage qeeb qeeb kev laus. Qhov no muaj tseeb los ntawm cov neeg uas siv nws tsis yog rau kev kho mob ntshav qab zib.

Prophylactic Metformin thiab nws ntau npaum li cas

Yog tias tus neeg rog dhau sijhawm, tom qab ntawd nws tuaj yeem siv tshuaj Metformin rau kev sojntsuam. Cov tshuaj no tso cai rau koj kom tshem tawm ob peb kilo ntawm qhov hnyav tshaj, nrog rau coj cov roj (cholesterol) li ib txwm, uas, dhau los, yog qhov kev tiv thaiv zoo tshaj plaws ntawm ntshav qab zib hom 2.

Ua ntej pib txoj kev txhaj tshuaj tiv thaiv kab mob, koj yuav tsum kawm cov lus qhia rau kev siv thiab ua kom ntseeg tau tias tsis muaj kev sib txuam.

Nws raug nquahu kom pib noj cov tshuaj Metformin thaum hnub nyoog 35-40 xyoo, txawm hais tias tsis muaj cov ntaub ntawv hloov tshiab ntawm qhov no. Ntxiv nrog rau kev kho mob qhov hnyav, koj yuav tsum tau yoog kom cov pluas noj qis carbohydrates. Nws yuav tsum nkag siab tias cov nyhuv ntawm cov ntsiav tshuaj yuav tsawg heev yog tias koj pheej noj tsis raug. Ntawm kev raug mob yog cov khoom muaj cov suab thaj ua kom zoo.

Rog neeg yuav tsum noj cov tshuaj Metformin ntau npaum ntawm 2550 mg rau ib hnub. Yog hais tias cov kev kho mob nqa tawm nrog ib cov tshuaj uas muaj lub cev ntev, tom qab ntawd cov tshuaj txhua hnub yuav tsum yog 2000 mg. Koj yuav tsum tau tsa nws mus zoo. Hauv thawj lub lis piam, nws yuav txaus noj 500-850 mg ntawm cov tshuaj ib hnub. Qhov no yuav ua rau lub cev hloov kho rau cov tshuaj.

Yog tias tus neeg tsis muaj teeb meem ntawm cov rog tshaj, thiab nws xav noj tshuaj Metformin tiv thaiv kev laus thaum ntxov, ces nws txaus los haus 500-1700 mg ntawm cov tshuaj ib hnub. Tsis muaj cov ntaub ntawv kho tshiab ntawm qhov teeb meem no.

Metformin tso cai rau koj kom koj poob ceeb thawj tsis muaj teeb meem rau kev noj qab haus huv, vim tias qhov tshuaj tsawg tsawg ua rau muaj kev mob tshwm sim ntau. Tsis tas li ntawd, nrog nws cov kev pab nws yog ib qho ua tau kom nruab nrab ntawm cov roj (cholesterol) thiab ntshav qabzib hauv cov ntshav.

Muab cov ntsiab lus tseeb no, nws tsis yog qhov ceeb uas metformin feem ntau siv rau kev poob phaus. Cov kev paub ntawm kev noj nws tau ntau tshaj 50 xyoo. Tshuaj Metformin-based tshuaj yog tsim los ntawm ntau lub tuam txhab ua tshuaj. Qhov no tso cai rau koj los khaws tus nqi qub tshuaj Glucofage nyob rau hauv qis.

Txhawm rau kom tsis txhob ua rau mob kev loj hlob ntawm cov kev mob tshwm sim, metformin yuav tsum tau noj tshuaj me me (hauv thawj koob). Ua ntej pib kev sib ntaus tawm tsam tshaj qhov hnyav, koj yuav tsum paub tseeb tias ib tus neeg tsis muaj kev sib txuam nrog kev siv tshuaj.

Npaum li cas koj tuaj yeem poob nrog metformin?

Yog tias koj tsis rov txhim kho koj qhov kev noj haus thiab tsis tawm dag zog, ces koj yuav tsis ua kom poob phaus ntau tshaj 2-4 kg.

Thaum tom qab 1.5-2 lub hlis txij li pib noj cov tshuaj metformin, qhov tshwm sim tsis tuaj thiab qhov hnyav tseem nyob rau theem yav dhau los, qhov no yuav qhia tau tias tus neeg muaj hypothyroidism. Nco ntsoov sab laj tus kws tshaj lij thiab kuaj ntshav cov thyroid hormones txaus.

Tom qab cov zaub mov uas tsis muaj carbohydrate ua ke nrog metformin tuaj yeem txo qhov hnyav hnyav los ntawm 15 kg lossis ntau dua. Txhawm rau khaws cov txiaj ntsig no, koj yuav tsum tau noj tshuaj Metformin ua ntu zus. Tom qab muab cov ntsiav tshuaj tag, qhov hnyav tuaj yeem rov qab los.

Elena Malysheva hais tias metformin yog txoj kev kho rau cov laus, tab sis nws tsis qhia txog nws lub peev xwm los txo qhov hnyav tshaj. Tus neeg hu xov tooj TV uas muaj koob muaj npe pom zoo kom ua raws li nws txoj kev noj zaub mov, thiab tsis txhob siv tshuaj rau qhov poob phaus. Txawm li cas los xij, xws li kev ntsuas no tsis haum rau txhua tus neeg.

Metformin thiab hypothyroidism

Metformin tuaj yeem noj nrog hypothyroidism, vim tias tus kab mob no tsis yog qhia tias yog kev tiv thaiv. Nws tseem raug tso cai siv nrog rau kev sib xyaw nrog tshuaj rau kev kho mob ntawm hypothyroidism. Nws yog tau hais tias qhov no yuav ua rau koj poob phaus thiab txhim kho kev noj qab haus huv.Txawm li cas los xij, tus kws kho mob yuav tsum koom nrog kev kho mob ntawm hypothyroidism, thiab metformin tsis muaj kev cuam tshuam rau hauv chav kawm ntawm tus kab mob.

Metformin thiab ntshav qab zib hom 2

Metformin yog yeeb tshuaj rau kev kho mob ntshav qab zib hom 2, uas tso cai rau koj los tswj qib siab ntawm cov ntshav qab zib ob leeg tom qab noj mov thiab hauv plab tas. Kev siv cov metformin tso cai rau koj los tiv thaiv kev txhim kho ntawm kev mob hnyav ntawm tus kab mob, kom ncua nws qhov ua tau thiab tsis ua mob rau kev noj qab haus huv. Metformin yuav tsum tsis txhob suav hais tias yog kev kho mob tsis zoo uas yuav pab kho kom ntshav qab zib. Tau kawg, muaj qee kis thaum tus neeg mob nrog kev rog, thiab tus kab mob thim rov qab, uas tso cai rau tso tseg kev siv cov metformin, tab sis cov xwm txheej zoo li no tsis tshua muaj tshwm sim.

Yog tias ib tug neeg noj tshuaj metformin tsis tu ncua thiab ntev ntev, tom qab ntawv qhov no yuav ua kom cov ntshav qab zib, qib roj thiab triglycerides nyob rau hauv cov ntshav, nrog rau tshem tawm ntau dhau.

Metformin yog ib qho tshuaj zoo, yog li ntawd, nws tau sau tseg rau kev kho mob ntshav qab zib thiab kev rog rog hauv cov menyuam yaus hnub nyoog 10 xyoo. Koj yuav tsum pib noj cov tshuaj nrog tshuaj tsawg kawg yog 500-850 mg ib hnub, maj mam nqa cov tshuaj txhua hnub rau 2250 mg. Yog tias cov tshuaj Glucofage Ntev siv rau kev kho mob, tom qab ntawd ib koob tshuaj tsawg dua 2000 mg yuav tsum noj ib hnub.

Txhawm kom tswj ntshav qab zib thiab qhov hnyav tau tswj hwm tshwj xeeb nrog kev pab ntawm cov tshuaj yuav tsis ua tiav. Tus neeg mob yuav tsum tau ua raws noj zaub mov noj. Txwv tsis pub, ntshav qab zib yuav txuas ntxiv ua txoj kev vam meej thiab ua rau txoj kev txhim kho ntawm cov mob hnyav.

Hom tshuaj twg uas metformin ua rau kom cov ntshav qab zib tsawg dua?

Rau kev kho mob ntshav qab zib, glucophage yog preferable. Nov yog ib qho tshuaj yeeb ntawm tus nqi pheej yig rau ntau tus neeg. Koj tuaj yeem nqa nws cov analogue Siofor.

Txhawm rau tiv thaiv cov ntshav qab zib kom tsis txhob nce thaum sawv ntxov, koj tuaj yeem siv cov tshuaj Glucofage Ntev. Nws tau noj ua ntej mus pw, yog li nws yuav ua haujlwm txhua hmo. Thaum qhov kev ntsuas no tsis ua kom cov suab thaj nyob ruaj khov, yuav tsum muaj cov insulin txhaj tshuaj. Nws yuav tsum nco ntsoov tias sawv ntxov cov ntshav qabzib nyob hauv lub cev pab txhawb kev txhim kho cov ntshav qab zib muaj teeb meem. Yog li ntawd, cov jumps no tsis tuaj yeem tsis quav ntsej.

Yog tias kuv muaj mob raws plab los ntawm metformin lossis nws tsis pab, yog li muaj dab tsi hloov nws?

Nws yog qhov nyuaj kom nrhiav tau hloov rau cov tshuaj metformin - nws yog qhov tshwj xeeb rau kev txo cov ntshav qab zib.

Yog li, ua ntej koj yuav tsum tau sim ua kom tsis txhob mob raws plab, kom tsis txhob nrhiav kev hloov pauv rau cov tshuaj metformin. Ua qhov no, pib kho nrog tsawg koob tshuaj yeeb tshuaj. Qhov no yuav ua rau lub cev hloov kho rau cov tshuaj thiab tsis teb rau nws los ntawm qhov tsis ua tiav ntawm cov zom zaub mov.

Tsawg tsawg zaus, muaj tshuaj pab txhawb kev mob tso tawm. Yog li no, rau ib lub sijhawm koj tuaj yeem hloov lawv nrog cov tshuaj Metformin ua ke.

Yog tias noj cov tshuaj tsis txo cov ntshav qab zib, tom qab ntawv nws yuav ua rau tus neeg muaj mob ntshav qab zib hom 1. Tib lub sijhawm, cov txiav tau ua tiav tag nrho nws cov chaw cia thiab tsis tuaj yeem tsim cov tshuaj insulin. Tom qab ntawd koj yuav tsum hloov mus rau kev txhaj tshuaj ntawm cov tshuaj no. Txwv tsis pub, ib tug neeg tuaj yeem tuag vim mob ntshav qab zib. Cov tshuaj yuav tsum tau muab pov tseg.

Nyob rau hauv ib qho xwm txheej uas metformin ua rau cov ntshav qab zib tsawg, tab sis qhov no tsis txaus, kev kho tuaj yeem muab ntxiv nrog kev txhaj tshuaj insulin, tab sis hauv kev txhaj tshuaj me.

Yog tias ib tus neeg muaj lub cev tsis tshua hnyav, tab sis nws txhim kho ntshav qab zib, tom qab ntawd cov neeg mob yuav tsum tau muab tshuaj insulin tam sim ntawd. Cov tshuaj hlawv ntshav qab zib yuav tsis tso cai koj los tiv thaiv tus kabmob.

Noj tshuaj metformin ua rau cov ntshav qab zib nce ntxiv, yog vim li cas?

Metformin yuav tsis pab txo cov ntshav qab zib yog yam ntshav qab zib hom 2 hnyav heev, lossis thaum tus neeg kuaj ntshav mob ntshav qab zib hom 1 tsawg. Hauv qhov no, yuav tsum tau txhaj tshuaj insulin, nrog rau kev noj haus.

Tus kws kho mob yuav qhia kom hloov lossis ntxiv cov kev npaj cov tshuaj metformin nrog rau cov tshuaj xws li: Diabeton MV, Amaril, Manil, etc. Cov tshuaj uas tsim tawm tshiab kuj tseem muaj rau kev yuav, suav nrog Januvia, Galvus, Forsiga, Jardins, thiab lwm yam Yog tias lawv siv tsis tas tso cai rau koj kom ua tiav cov nyhuv yam xav tau, tom qab ntawd koj yuav tsum hloov mus rau kev txhaj tshuaj insulin. Tsis kam ua cov kev kho tshuaj insulin yuav tsum tsis yog. Ntxiv mus, noj tshuaj pab tuaj yeem txo qhov kev txhaj tshuaj insulin los ntawm 2-7 zaug. Qhov no tso cai rau koj kom cov piam thaj hauv qab tswj thiab tsis ua kom koj muaj mob.

Kev kho mob ntshav qab zib nrog metformin thiab insulin txhaj tshuaj

Feem ntau, kev npaj cov tshuaj metformin yog kws kho nyob hauv ib txoj kev nyuaj nrog kev txhaj tshuaj insulin. Qhov no yuav kho cov qib qab zib ntawm 4.0-5.5 mmol / L.

Tsuas yog los ntawm kev noj zaub mov noj thiab kev tswj hwm qhov ncauj qab zib ntawm cov tshuaj muaj ntshav qab zib tuaj yeem tswj tau yog tias nws nyob rau theem pib ntawm nws txoj kev loj hlob. Lwm qhov, yuav tsum tau txhaj tshuaj insulin qis. Qhov no muaj feem xyuam rau cov neeg mob uas cov suab thaj hauv qab tsis poob qis dua li ntawm 6.0-7.0 mmol / L. Nrog rau cov ntsuas no, cov teeb meem ntawm ntshav qab zib yuav vam meej, txawm hais tias tsis yog sai heev.

Yog tias peb xav txog cov kauj ruam rau kev kho mob ntshav qab zib mellitus, peb yuav tsum xub sim kho cov kev ua txhaum uas twb muaj lawm nrog kev pab los ntawm kev noj zaub mov ntawm kev noj zaub mov zoo thiab ua haujlwm rau lub cev. Tsuas yog tom qab ntawd lawv hloov mus rau haus cov tshuaj qab zib. Thaum cov nyhuv tsis tuaj yeem ua tiav, cov tshuaj insulin raug qhia. Qhov ntau npaum ntawm cov tshuaj insulin yuav tsum tau txo qis 25% yog tias tib lub sij hawm ib tus neeg tau txais cov tshuaj metformin npaj. Tshaj dhau qhov koob tshuaj ntawm cov tshuaj insulin thaum kho nrog cov tshuaj hlawv ntshav qab zib ua rau muaj kev tiv thaiv cov ntshav tsis txaus.

Ntxiv nrog rau cov txheej txheem kev kho mob sab saud, cov neeg mob ntshav qab zib yuav tsum ua si kis las. Nws pab tswj tus kabmob lossis khiav tawm, raws li nws tseem hu, qi-khiav. Koj tuaj yeem ua tau ntau yam rau koj lub cev kev ua si nrog Nordic taug kev.

Metformin: yuav lees li cas?

Metformin noj nrog zaub mov noj, uas txo qhov kev pheej hmoo ntawm phiv.

Cov tshuaj uas muaj lub cev ntev ntev yuav tsum noj tag nrho yam tsis ntxo. Lawv muaj cov cellulose matrix, uas yog lub luag hauj lwm rau kev tso tawm qeeb ntawm lub ntsiab nquag tshuaj. Qhov kev tawg ntawm xws li kev txhoj puab tshwm sim hauv cov hnyuv. Hauv qhov no, kev hloov pauv ntawm qhov quav txhawm rau muaj peev xwm ua tau, tab sis yog tsis muaj kev txhim kho raws plab. Qhov no tsis ua teeb meem rau kev noj qab haus huv.

Daim Ntawv Thov Kev Pab Lub Cev Nyuag

Nws puas tuaj yeem haus Metformin rau qhov poob phaus, yog tias qab zib yog qhov qub? Qhov kev coj ntawm cov tshuaj no yog vim nws lub peev xwm los tawm tsam tsis yog nrog cov plaques hauv cov hlab ntsha xwb, tab sis kuj nrog cov roj ntsha.

Lub cev poob thaum noj tshuaj tshwm sim vim cov hauv qab no:

kev kub ceev cov rog oxidation,
txo nyob rau hauv lub ntim ntawm nrhiav
qabzib cov qog ua ke los ntawm cov leeg nqaij.

Qhov no kuj tshem tawm cov kev xav ntawm kev tshaib kev nqhis, ua rau nce qhov nce nrawm hauv lub cev qhov hnyav. Tab sis koj yuav tsum hlawv roj thaum ua khoom noj.

Yuav kom poob ceeb thawj, koj yuav tsum tso tseg:

Kev ua kom tsawg, xws li kev tawm dag zog txhua hnub, kuj tseem xav tau. Yuav tsum ua tib zoo tswj kev haus cawv. Tab sis kev haus cawv tsis txwv tsis pub.

Nws yuav tsum nco ntsoov tias kev poob phaus tsuas yog ib qho ntxiv ntawm cov tshuaj xwb. Thiab tsuas yog kws kho mob tuaj yeem txiav txim siab qhov kev xav tau ntawm Metformin los tawm tsam kev rog dhau.

Daim ntawv thov rau anti-aging (anti-aging)

Metformin tseem tseem siv txhawm rau tiv thaiv kev hloov pauv ntsig txog lub hnub nyoog hauv lub cev.

Txawm hais tias cov tshuaj tsis yog panacea rau cov hluas nyob mus ib txhis, nws tso cai rau koj:

rov qab muab cov khoom ntim ntawm lub paj hlwb mus rau qhov xav tau ntim,
txo cov kev pheej hmoo ntawm malignant neoplasms,
ntxiv dag zog rau lub plawv mob.

Cov teeb meem tseem ceeb ntawm cov kab mob kev laus yog atherosclerosis, uas cuam tshuam txoj haujlwm ntawm lub plawv thiab cov hlab ntsha. Nws yog nws leej twg ua rau feem ntau ntawm kev tuag uas tshwm sim ua ntej.

Kev tso cov roj (cholesterol) uas ua rau atherosclerosis tshwm sim vim:

ua txhaum ntawm txoj haujlwm ua haujlwm ntawm tus txiav,
malfunction hauv lub nruab nrog cev,
teeb meem metabolic.

Qhov laj thawj tseem yog kev ua neej nyob sedentary uas cov neeg laus coj, thaum tswj kom muaj tib lub ntim thiab cov calories ntau ntawm cov zaub mov, thiab qee zaum txawm tias dhau lawv.

Qhov no ua rau stagnation ntawm cov ntshav hauv cov hlab ntsha thiab tsim muaj cov roj cholesterol khaws cia. Cov tshuaj pab txhawm rau txo cov roj cholesterol, txhim kho ntshav ncig thiab rov ua haujlwm ntawm txhua yam hauv nruab nrog cev thiab kab ke. Yog li yuav siv Metformin noj yog tsis muaj ntshav qab zib? Nws yog ua tau, tab sis tsuas yog thaum tsis muaj contraindications.

Cov kev tiv thaiv tsis haum rau kev siv Metformin yog:

acidosis (mob siab los yog mob ntev),
lub sijhawm cev xeeb tub, pub mis,
ua xua rau cov tshuaj no,
mob siab los yog mob plawv,
myocardial infarction
cov cim qhia ntawm hypoxia thaum noj cov tshuaj no,
lub cev qhuav dej ntawm lub cev nrog cov kab mob sib kis,
lub plab zom mov (kab mob),
kev siv dag zog ntau dhau.

Thov Metformin rau qhov kev poob phaus thiab lub cev rov qab yog qhov tsim nyog yuav tau coj mus rau hauv tus account qhov tshwm sim tuaj yeem tshwm sim:

kev pheej hmoo ntxiv rau txoj kev tsis nco qab
xeev siab, ntuav, raws plab yuav tshwm sim,
qee zaum nws yuav yog xim hlau zoo li
anemia tej zaum yuav tshwm sim
muaj ib qho kev txo qis ntawm cov B-vitamins, thiab ntxiv cov tau txais ntawm kev npaj muaj lawv yuav tsum,
nrog kev siv ntau dhau, hypoglycemia yuav tshwm sim,
kev fab tshuaj tsis haum yuav ua rau muaj teeb meem ntawm daim tawv nqaij.

Mob ntshav qab zib yog dab tsi thiab vim li cas nws thiaj li txaus ntshai?

Mob ntshav qab zib mellitus tau muab faib ua ob hom. Ntshav Qab Zib Hom 1 hu ua insulin-vam khom. Nrog hom mob no, kev sib txuas ntawm cov enzyme tshwj xeeb hauv cov txiav ua kab mob, insulin, uas zom cov piam thaj, yog qhov tsis taus. Ntshav qab zib Hom 2 hu ua non-insulin dependant. Nrog rau cov ntshav qab zib hom no, kev ua haujlwm hauv lub cev ua rau lub siab tsis muaj qhov tsis zoo, txawm li cas los xij, muaj qhov txo qis ntawm cov tshuaj insulin nyob rau hauv cov ntaub so ntswg feem ntau ntawm lub cev, thiab cov piam thaj hauv cov nqaij hauv lub siab tseem nce ntxiv.

Cov neeg feem ntau mob tus mob ntshav qab zib hom 2 nyob rau lub hnub nyoog laus, tab sis tsis ntev los no cov ntshav qab zib tau dhau los pom tias "yau dua". Cov laj thawj rau qhov no yog kev ua neej nyob sedentary, kev nyuaj siab, ntxiv rau cov zaub mov ceev thiab kev noj haus tsis zoo. Lub caij no, ntshav qab zib yog ib qho txaus ntshai heev, uas qhov tsis muaj cov kev qhia sab nraud loj heev ua rau muaj kev pheej hmoo mob ntshav siab thaum ntxov thiab mob hlab ntsha tawg, ntshav thiab ntshav vau. Yog li, cov kws tshawb nrhiav tau nrhiav ntev ntev rau cov tshuaj uas yuav pab txo qis cov ntshav qab zib thiab tib lub sij hawm yuav tsis ua mob rau lub cev.

Qhia txog ntawm cov tshuaj

Los ntawm cov txheej txheem tshuaj lom neeg, metformin hais txog biguanides, derivatives ntawm guanidine. Hauv kev coj ua, guanidine pom nyob hauv qee cov nroj tsuag, piv txwv li, nyob rau hauv kev siv tshuaj tua tshis, uas tau siv los kho mob ntshav qab zib txij thaum Hnub nyoog Nruab Nrab. Txawm li cas los xij, cov tshuaj ntshiab guanidine muaj kuab lom rau lub siab.

Metformin tau muab tso ua ke raws li guanidine rov qab rau hauv 20s ntawm lub xyoo pua xeem. Txawm tias tom qab ntawd, nws tau paub txog nws cov khoom hauv hypoglycemic, tab sis lub sijhawm ntawd, vim yog zam rau cov tshuaj insulin, cov tshuaj tau hnov qab rau qee lub sijhawm.Tsuas yog nyob rau xyoo 1950, thaum nws tau pom tseeb tias kev kho mob insulin rau tus mob ntshav qab zib hom 2 muaj ntau yam tsis zoo, cov tshuaj pib siv los ua tus neeg sawv cev tiv thaiv kab mob thiab tom qab lub sijhawm luv luv tau txais kev lees paub vim nws cov hauj lwm zoo, muaj kev nyab xeeb thiab muaj tsawg ntawm cov kev mob tshwm sim thiab sib deev.

Niaj hnub no, metformin tau suav hais tias yog cov tshuaj tshaj plaws hauv lub ntiaj teb. Nws muaj npe hauv WHO Cov Tshuaj Tseem Ceeb. Nws tau ntseeg tau tsim tias kev siv cov tshuaj metformin tsis tu ncua txo txoj kev pheej hmoo ntawm txoj kev tuag los ntawm cov kab mob ntawm cov hlab plawv los ntawm ntshav qab zib. Cov kev tshawb fawb pom tau tias hauv cov neeg rog thiab hom 2 mob ntshav qab zib, kev kho mob nrog metformin yog 30% ntau dua kev kho mob nrog insulin thiab lwm yam tshuaj tiv thaiv kab mob, thiab 40% zoo dua kev kho mob nrog kev noj zaub mov noj ib leeg. Piv nrog rau lwm cov tshuaj tiv thaiv kab mob, cov tshuaj muaj tsawg phiv, nrog kev kho mob monotherapy nws xyaum tsis ua rau muaj kev mob ntshav qis, nws tsis tshua muaj kev phom sij txaus ntshai - lactic acidosis (mob ntshav nrog lactic acid).

Metformin belongs rau cov chav kawm ntawm cov tshuaj uas npaj rau kev kho mob ntshav qab zib hom 2. Tom qab noj cov tshuaj Metformin, nws txo cov ntsiab lus ntawm cov piam thaj hauv cov ntshav, qib ntawm glycosylated hemoglobin thiab ua rau lub cev muaj cov ntshav siab dua. Cov tshuaj tsis muaj cov khoom carcinogenic, tsis cuam tshuam rau kev muaj menyuam.

Tus txheej txheem ntawm kev kho mob ntawm metformin yog ntau yam. Ua ntej tshaj plaws, nws txo qis tsim kom muaj cov piam thaj hauv daim siab ua haujlwm. Hauv hom 2 Ntshav Qab Zib, ntau lawm cov piam thaj hauv lub siab yog ntau zaus dua li ib txwm. Metformin txo qhov ntsuas no los ntawm ib feem peb. Qhov kev txiav txim no tau piav qhia los ntawm kev ua kom muaj metformin ntawm qee yam ua rau daim siab, uas ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv cov piam thaj thiab cov rog.

Txawm li cas los xij, qhov kev siv ntawm metformin txo hauv cov ntshav qabzib tsis yog txwv rau kev tsim kom muaj cov kua nplaum hauv lub siab. Metformin tseem muaj cov kev coj tshwm sim hauv lub cev:

txhim kho cov txheej txheem metabolic,
txo qhov nqus ntawm cov piam thaj los ntawm cov hnyuv,
txhim kho kev siv cov kua nplaum nyob rau hauv cov ntaub so ntswg peripheral,
nce cov nqaij mos rhiab rau insulin,
muaj cov nyhuv fibrinolytic.

Thaum tsis muaj cov tshuaj insulin nyob rau hauv cov ntshav, cov tshuaj tsis qhia nws qhov kev ua haujlwm hypoglycemic. Tsis zoo li ntau lwm cov tshuaj tiv thaiv kab mob, metformin tsis ua rau muaj kev phom sij txaus ntshai - lactic acidosis. Tsis tas li ntawd, nws tsis cuam tshuam rau kev tsim cov tshuaj insulin los ntawm cov hlwb ntawm tus txiav. Tsis tas li, cov tshuaj muaj peev xwm txo qis cov roj "tsis zoo" - ntshav qab zib tsawg lipoproteins thiab triglycerides (tsis txo cov roj "zoo" - lipoproteins ntau), txo qis tus nqi ntawm cov roj oxidation thiab kev tsim cov roj dawb. Qhov tseem ceeb, cov metformin qib muaj peev xwm ntawm cov tshuaj insulin los txhawb kev tsim cov rog nqaij, yog li cov tshuaj muaj peev xwm txo qis lossis txhim kho lub cev qhov hnyav. Cov cuab yeej kawg ntawm metformin yog vim li cas cov tshuaj no feem ntau siv los ntawm cov uas xav kom poob phaus.

Nws kuj tseem yuav tsum tau sau tseg txog qhov muaj txiaj ntsig zoo uas cov tshuaj muaj rau lub plawv hlab plawv. Metformin ntxiv dag zog rau cov leeg ntawm cov hlab ntshav cov hlab ntshav, tiv thaiv kev txhim kho mob ntshav qab zib.

Cov Tshuaj Pharmacokinetics

Hauv cov ntsiav tshuaj, metformin yog nthuav tawm ua hydrochloride. Nws yog cov tsis muaj kob tsis muaj hluav taws xob zom cov hmoov, zoo heev soluble hauv dej.

Metformin yog hom tshuaj uas siv tshuaj qeeb. Feem ntau, qhov tshwm sim zoo ntawm kev noj nws yuav pib tshwm tom qab 1-2 hnub. Lub sijhawm no, muaj kev sib luag ntawm cov tshuaj hauv cov ntshav, nce mus txog 1 μg / ml. Hauv qhov no, qhov siab tshaj plaws ntawm cov tshuaj hauv cov ntshav tuaj yeem pom nws twb muaj 2.5 teev tom qab kev coj noj coj ua.Cov tshuaj tsis muaj zog txaus khi rau cov ntshav protein. Ib nrab-lub neej yog 9-12 teev .Nws yog tsuas yog hloov los ntawm lub raum tsis hloov.

Cov neeg uas lub raum tsis ua hauj lwm zoo yuav muaj kev txuam nrog cov tshuaj hauv lub cev.

Qhov tseem ceeb qhia rau kev siv tshuaj Metformin yog hom ntshav qab zib 2. Ntxiv mus, tus kab mob no yuav tsum tsis txhob muaj teeb meem los ntawm ketoacidosis. Nws yog qhov zoo dua rau kev muab tshuaj rau cov neeg mob uas tsis tau txais txiaj ntsig los ntawm kev noj zaub mov kom tsis raug, zoo rau cov neeg mob rog. Hauv qee kis, cov tshuaj muaj peev xwm siv nrog kev siv tshuaj insulin. Tsis tas li, cov tshuaj muaj peev xwm qee zaum sau tseg rau mob ntshav qab zib hauv kev xeeb tub (mob ntshav qab zib los ntawm kev muaj menyuam hauv plab).

Cov tshuaj kuj tseem tuaj yeem siv yog tias tus neeg tau hnov mob insulin tsis ua haujlwm, tab sis cov piam thaj hauv ntshav hauv lub cev tsis tshaj qhov tseem ceeb. Tus mob no yog hu ua mob ntshav qab zib. Txawm li cas los xij, cov kws tshaj lij feem ntau nyob hauv qhov tseeb tias qhov xwm txheej no, kev tawm dag zog thiab kev noj zaub mov kom zoo dua, thiab cov tshuaj tiv thaiv kab mob nrog cov ntshav qab zib ua tsis tau zoo.

Tsis tas li ntawd, cov tshuaj tuaj yeem raug teem rau qee lwm yam kabmob, piv txwv li, nrog polycystic zes qe menyuam, tsis yog cawv cawv daim siab pathologies, kev ua tiav thaum ntxov. Cov kab mob no tau sib koom tes los ntawm qhov tseeb tias nrog lawv muaj insensitivity ntawm cov ntaub so ntswg rau insulin. Txawm li cas los xij, qhov ua tau zoo ntawm metformin hauv cov kab mob no tseem tsis tau muaj pov thawj nyob rau hauv cov ntshav qab zib ib yam. Qee zaum cov tshuaj kuj tseem siv rau qhov poob phaus, txawm hais tias cov tshuaj tshwj xeeb kho qhov kev siv cov tshuaj metformin nrog cov neeg tsis txaus ntseeg, tshwj xeeb tshaj yog tias peb tsis hais txog cov neeg muaj kab mob nyhav dhau los.

Daim ntawv tso tawm

Cov tshuaj muaj rau cov tshuaj uas muaj tshuaj ntau npaum li 500 thiab 1000 mg. Kuj tseem muaj cov ntsiav tshuaj ua haujlwm ntev nrog cov tshuaj 850 mg, txheej nrog cov tshuaj pleev xim tshwj xeeb.

Cov yam ntxwv tseem ceeb ntawm metformin uas muaj cov tib cov tshuaj yeeb yam muaj xws li cov neeg sawv cev ntawm Fabkis Glucofage. Cov tshuaj no yog suav tias yog thawj, thiab qhov seem ntawm cov tshuaj nrog metformin, tsim los ntawm ntau lub tuam txhab tshuaj thoob ntiaj teb - yog cov generics. Cov tshuaj no tau muab faib hauv lub tsev muag tshuaj yam tsis muaj daim ntawv yuav tshuaj.

Cov Yuav Tsum Muaj

Cov tshuaj muaj ib tug xov tooj ntawm contraindications:

cov qauv mob hnyav hauv lub plawv, ua pa thiab lub raum tsis ua haujlwm,
lub siab ua tsis taus haujlwm,
ntse
cov kev huam yuaj ntawm cerebrovascular,
mob ketoacidosis,
mob ntshav qab zib coma thiab precoma,
lactic acidosis (nrog rau keeb kwm ntawm)
kab mob thiab kev mob uas muaj kev pheej hmoo ntawm lub raum ua tsis zoo,
lub cev qhuav dej
mob hnyav (feem ntau bronchopulmonary thiab lub raum),
hypoxia
kev phais hnyav ua haujlwm (hauv qhov no, kev siv tshuaj insulin yog qhia),
haus cawv ntev ntev los yog cawv dej cawv (muaj kev pheej hmoo ntawm cov mob lactic acidosis),
kev kuaj mob nrog kev qhia txog ntawm iodine-muaj tshuaj (ob hnub ua ntej txheej txheem thiab ob hnub tom qab),
hypocaloric noj tshuaj (tsawg dua 1000 Kcal tauj ib hnub),
theem siab ntawm creatinine hauv cov ntshav (135 μmol / l hauv cov txiv neej thiab 115 μmol / l hauv cov poj niam),
Ntshav qab zib mob ko taw
npaws.

Nrog kev ceev faj, cov tshuaj yuav tsum yog cov kws kho mob rau cov neeg laus thiab cov neeg ua haujlwm lub cev hnyav (vim tias muaj kev pheej hmoo ntawm cov kab mob lactic acidosis).

Cov tshuaj tsis pom zoo rau cov neeg mob uas muaj hnub nyoog qis dua 18 xyoo, thaum cev xeeb tub thiab lactation, nrog rau kev mob siab ntxiv rau cov tshuaj. Muaj qee kis, nws muaj peev xwm siv cov tshuaj no thaum cev xeeb tub thiab menyuam yaus (ntau dua 10 xyoo) nyob hauv kev saib xyuas ntawm tus kws kho mob nruj.

Cov lus qhia tshwj xeeb

Yog tias kev kho mob txuas ntxiv, tom qab ntawd lub raum ua haujlwm yuav tsum tau saib xyuas. Tsawg kawg yog ob zaug hauv ib xyoos, nws yog ib qhov tsim nyog yuav tau kuaj xyuas lub ntsiab ntawm lactic acid hauv cov ntshav.Yog tias mob nqaij ntshiv, tam sim ntawd tshawb xyuas qhov concentration ntawm lactic acid.

Tsis tas li, 2-4 zaug hauv ib xyoos yuav tsum kuaj xyuas lub raum kev ua haujlwm (qib creatinine hauv cov ntshav). Qhov no muaj tseeb tshwj xeeb ntawm cov neeg laus.

Nrog rau cov tshuaj tua kab mob, cov tshuaj tsis cuam tshuam rau lub hauv nruab nrab cov hlab hlwb, yog li nws muaj peev xwm siv cov tshuaj hauv cov neeg tsav tsheb thiab ua haujlwm uas yuav tsum muaj kev kub siab.

Sab sij huam

Cov kev phiv loj thaum noj cov tshuaj metformin yog txuam nrog kev mob txoj hnyuv. Ntau zaus thaum noj tshuaj, muaj tshwm sim xws li mob plab, xeev siab, ntuav, pom tau. Txhawm rau zam qhov no, cov ntsiav tshuaj yuav tsum tau noj thaum lub sijhawm lossis tom qab noj mov tas. Nws tseem muaj peev xwm ua tau qhov tsos ntawm cov xim hlau hauv lub qhov ncauj, tsis muaj qhov tsis qab los noj mov, tawv nqaij ua pob.

Tag nrho cov kev mob tshwm sim saum toj no tsis ua rau muaj kev hem thawj. Lawv feem ntau tshwm sim thaum pib ntawm txoj kev kho thiab dhau los ntawm nws tus kheej. Txhawm rau kom zam kev tsis txaus siab tshwm sim cuam tshuam nrog lub plab zom mov, antispasmodics lossis antacids tuaj yeem nqa mus.

Tsis tshua muaj, cov tshuaj tuaj yeem ua rau cov kab mob lactic acidosis, megaloblastic anemia, hypoglycemia, txo qis hauv kev tsim cov thyroid hormones thiab testosterone nyob rau hauv cov txiv neej. Kev mob ntshav qab zib feem ntau tshwm sim yog tias lwm yam tshuaj tiv thaiv kab mob ntshav siab, piv txwv li, sulfonylureas, noj nrog tshuaj metformin. Nrog kev siv ntev, cov tshuaj tuaj yeem ua rau cov vitamin B12 tsis txaus.

Hypoglycemic teebmeem tsis raug cais tawm thaum noj NSAIDs, ACE inhibitors thiab MAO, beta-blockers, cyclophosphamide. Thaum noj GCS, epinephrine, sympathomimetics, diuretics, cov thyroid hormones, glucagon, estrogens, calcium antagonists, nicotinic acid, ntawm qhov tsis sib thooj, cov nyhuv ntawm cov tshuaj txo qis.

Cov tshuaj noj uas muaj iodine tuaj yeem ua rau lub raum tsis ua haujlwm thiab ua rau muaj kev mob siab ntau ntxiv. Yog tias xav tau cov mob lactic acid, yuav tsum tau mus pw hauv tsev kho mob sai.

Cov lus qhia rau kev siv

Raws li txoj cai, thaum pib kho, tshuaj yuav tsum siv 0.5-1 g ib hnub ib zaug. Qhov tsuas tshuaj no yuav tsum tau ua raws li peb hnub. Txij li 4 mus rau 14 hnub nws yog qhov tsim nyog yuav tau noj cov tshuaj metformin 1 g peb zaug ib hnub. Yog tias cov piam thaj nyob hauv cov qib qis dua, qhov koob tshuaj yuav raug txo kom tsawg. Raws li kev saib xyuas txij nkawm, cov tshuaj metformin yuav tsum noj ntawm 1500-2000 mg rau ib hnub. Nyob rau hauv cov ntaub ntawv ntawm ntev ua yeeb yam (850 mg), nws yog ib qhov tsim nyog yuav tsum noj cov tshuaj 1 ntsiav tshuaj ib hnub ob zaug - thaum sawv ntxov thiab yav tsaus ntuj.

Qhov siab tshaj plaws yog 3 g (6 ntsiav tshuaj ntawm tshuaj, 500 mg rau ib hnub) ib hnub. Hauv cov neeg laus, ua kom lub raum tsis zoo yog qhov ua tau, yog li ntawd, qhov siab tshaj plaws txhua hnub koob yuav tsum tsis pub tshaj 1000 mg (2 ntsiav tshuaj ntawm 500 mg tshuaj ib zaug). Lawv kuj yuav tsum tsis txhob cuam tshuam kev kho mob nrog rau cov tshuaj, hauv qhov xwm txheej lawv yuav tsum ceeb toom rau tus kws kho mob.

Nws yog qhov zoo tshaj rau noj cov ntsiav tshuaj tam sim ntawd tom qab noj mov nrog dej ntau. Kev noj cov tshuaj ncaj qha nrog zaub mov tuaj yeem txo nws txoj kev nqus hauv cov ntshav. Qhov koob tshuaj txhua hnub yog pom zoo kom muab faib ua 2-3 koob.

Kev noj tshuaj ntau npaum li cas thaum siv ua ke nrog cov tshuaj insulin (ntawm koob tshuaj insulin tsawg dua 40 units / hnub) feem ntau yog qhov tsis xws li tsis muaj tshuaj insulin. Hauv thawj hnub ntawm kev noj cov tshuaj metformin, cov koob tshuaj insulin yuav tsum tsis raug txo kom tsawg. Tom qab, qhov koob tshuaj insulin tuaj yeem txo qis. Tus txheej txheem no yuav tsum tau ua nrog kev saib xyuas ntawm tus kws kho mob.

Noj ntau dhau

Metformin yog ib cov tshuaj uas muaj kev nyab xeeb thiab txawm tias nws cov koob tshuaj loj (yog tias tsis muaj kev cuam tshuam nrog tshuaj), raws li txoj cai, tsis ua rau muaj kev phom sij txo cov ntshav qab zib. Txawm li cas los xij, nrog kev noj ntau dhau, muaj lwm qhov, tsis muaj tsawg dua qhov txaus ntshai - qhov nce ntawm cov tshuaj lactic acid hauv cov ntshav, uas yog hu ua lactic acidosis. Cov tsos mob ntawm tus kab mob lactic acid yog qhov mob ntawm lub plab thiab cov leeg, hloov hauv lub cev kub, ua rau tsis nco qab.Qhov kev cuam tshuam no thaum tsis muaj kev kho mob tuaj yeem ua rau tuag taus vim qhov tshwm sim ntawm txoj kev rov qab. Yog li ntawd, nyob rau hauv qhov kev tshwm sim uas rau qee qhov laj thawj kev tshaj tawm ntawm cov tshuaj tau tshwm sim, tus neeg mob yuav tsum tau coj mus rau tus kws kho mob. Nyob rau hauv cov ntaub ntawv ntawm overdose, kev kho mob yam ntxwv yog ua. Kev tshem tawm cov tshuaj ntawm cov ntshav siv hemodialysis yog tseem ua haujlwm zoo.

Metformin yog cov tshuaj nrov tshaj plaws rau hom ntshav qab zib 2, nrog rau kev poob phaus thiab kho mob polysystosis ntawm zes qe menyuam rau poj niam. Nws ua rau nws cov ntshav qab zib qis thiab pab kom poob phaus ntxiv yam tsis ua rau muaj kev mob tshwm sim ntau. Nws rub lub neej ntev, txo qis kev pheej hmoo ntawm lub plawv nres thiab mob hlab ntsha tawg, nrog rau qee yam mob qog ntshav. Cov ntsiav tshuaj no muaj tus nqi pheej yig, vim tias lawv tau tsim los ntawm kaum ob ntawm cov chaw muag tshuaj ntawm kev sib tw.

Nyeem cov lus teb rau cov lus nug:

Cov hauv qab no yog cov lus qhia kev qhia sau ua hom lus yooj yim. Tshawb nrhiav cov cim, tsis pom kev zoo, tshuaj noj, ntxiv rau kev noj tshuaj kom tsawg dua kev phiv.

Metformin rau cov ntshav qab zib thiab poob phaus: cov lus ntxaws ntxaws

Nyeem kuj cov neeg mob tshuaj xyuas seb cov tshuaj metformin cuam tshuam rau lub raum thiab mob siab npaum li cas, cov ntsiav tshuaj sib txawv npaum li cas, thiab lawv cov lus Lav Xias.

Cov tshuaj no puas raug muab tshuaj rau?

Cov cim kev qhia rau kev siv yog hom ntshav qab zib 2, nrog rau hom ntshav qab zib 1, nyuaj los ntawm kev hnyav dhau thiab insulin tsis kam hauv tus neeg mob. Txawm li cas los xij, coob tus neeg siv tshuaj metformin kom poob phaus dua li kho ntshav qab zib. Tsis tas li, cov tshuaj no pab nrog polycystic ovary syndrome (PCOS) hauv cov poj niam, muaj feem ntau ua kom cev xeeb tub. Kev siv cov metformin rau kev poob phaus thiab tswj ntshav qab zib tau piav qhia txhua yam hauv qab no.

Lub ncauj lus ntawm kev kho mob PCOS yog dhau ntawm qhov ua haujlwm ntawm lub xaib no. Cov poj niam uas tau ntsib nrog cov teeb meem no, koj yuav tsum xub mus, ua kev tawm dag zog, noj tshuaj thiab ua raws li lwm tus kws kho mob poj niam cov lus pom zoo. Txwv tsis pub, lawv yuav muaj txoj hmoo tsis tshua muaj menyuam thiab muaj kev pheej hmoo siab tias yuav mob ntshav qab zib hom 2 muaj hnub nyoog 35-40 xyoo.

Puas yog Metformin Ntev Npua Lub Neej?

Metformin qhia qhov tseeb ncua lub neej ntawm cov neeg mob uas muaj ntshav qab zib hom 2, qeeb lawv txoj kev loj hlob ntawm cov teeb meem. Nws tseem tsis tau raug pov thawj tseeb tias cov tshuaj no pab tau cov neeg muaj ntshav muaj ntshav qab zib txij thaum laus los. Kev tshawb nrhiav loj ntawm qhov teeb meem no tau pib lawm, tab sis lawv cov txiaj ntsig yuav tsis muaj sai sai no. Txawm li cas los xij, ntau tus neeg muaj koob npe nyob rau sab hnub poob lees paub tias lawv lees txais, ua rau qeeb lawv cov laus. Lawv tau txiav txim siab tsis tos rau kev lees paub tseeb.

Cov kws kho mob uas muaj suab npe thiab TV presenter Elena Malysheva tseem pom zoo cov tshuaj no ua cov tshuaj rau cov laus.

Tus thawj coj hauv tsev kawm ntawv txiav txim siab lub plausible txoj kev xav uas metformin qeeb qeeb kev laus, tshwj xeeb tshaj yog cov neeg rog. Elena Malysheva feem ntau tshaj tawm cov ntaub ntawv tsis raug lossis cov ntaub ntawv qub. Tus mob ntshav qab zib uas nws tau hais txog tsis pab txhua. Tab sis ntawm qhov hais txog metformin, ib tus tuaj yeem pom zoo nrog nws. Qhov no yog cov tshuaj zoo heev, thiab tsis muaj kev phiv tshuaj, yog tias koj tsis muaj contraindications los kho lawv.

Yuav siv tshuaj metformin rau kev tiv thaiv? Yog li, nyob rau hauv dab tsi dosages?

Yog tias koj muaj tsawg dua qhov hnyav dua, nws ua rau pom kev noj cov tshuaj metformin rau kev tiv thaiv, pib ntawm hnub nyoog nruab nrab. Cov tshuaj no yuav pab kom poob phaus, txhim kho cov roj cholesterol, thiab txo cov kev pheej hmoo ntawm mob ntshav qab zib hom 2.

Ua ntej koj pib haus cov tshuaj no, ua tib zoo kawm, tshwj xeeb yog ntu ntawm contraindications thiab phiv.

Tsis muaj tseeb cov ntaub ntawv thaum muaj hnub nyoog li cas koj tuaj yeem pib noj cov tshuaj metformin. Piv txwv li, hauv 35-40 xyoo. Nco ntsoov tias cov tshuaj tseem ceeb yog qhov no. Ib qho tshuaj twg, txawm tias kim tshaj plaws, tsuas yog ua tiav cov nyhuv uas cov khoom noj yuav muaj rau koj lub cev. Refined carbohydrates muaj kev phom sij heev.Tsis muaj cov tshuaj phom sij tuaj yeem them lawv cov teeb meem tsis zoo.

Cov neeg rog yog qhia kom maj mam nqa cov tshuaj txhua hnub mus rau qhov ntau - 2550 mg ib hnub rau qhov ib txwm siv tshuaj thiab 2000 mg rau ncua tshuaj tawm (thiab cov tshuaj ntxiv). Pib noj 500-850 mg ib hnub twg thiab tsis txhob maj nce qhov ntau ntxiv kom lub cev muaj sij hawm yoog.

Piv txwv tias koj tsis muaj qhov hnyav tshaj txhua qhov, tab sis koj xav noj cov metformin kom tiv thaiv kev hloov pauv hnub nyoog. Hauv qhov no, nws tsis yog tsim nyog siv qhov ntau tshaj cov tshuaj. Sim 500-1700 mg ib hnub twg. Hmoov tsis, tsis muaj xov xwm meej txog kev noj tshuaj tiv thaiv kom zoo rau cov neeg nyias nyias.

Kuv puas yuav tsum haus cov tshuaj no rau ntshav qab zib?

Yog lawm, metformin yuav pab yog tias koj rog dhau, tshwj xeeb tshaj yog cov rog ua rau lub plab thiab ncig ntawm lub duav. Kho nrog cov tshuaj no yuav txo tau qhov ntxim siab tias ntshav qab zib yuav dhau los ua hom ntshav qab zib 2.

Koj yuav tsum tau noj cov tshuaj metformin rau cov kev poob phaus raws li cov qauv uas tau piav qhia hauv nplooj ntawv no, nrog kev nce cov ncauj lus tsawg zuj zus txhua hnub. Nyeem kom zoo zoo thiab paub tseeb tias koj tsis muaj kev sib tshooj rau kev siv lub cuab yeej no. Nws yog qhov tsim nyog kom rov ua dua ib zaug ntxiv uas fatty hepatosis tsis yog contraindication.

Koj yuav hnyav npaum li cas kg los poob ntawm metformin?

Koj tuaj yeem cia siab kom poob 2-4 kg yog tias koj tsis hloov koj qhov kev noj zaub mov thiab qib kev tawm dag zog. Tej zaum nws yuav muaj hmoo los poob ntau phaus, tab sis tsis muaj kev lees paub.

Peb rov qab hais tias metformin yuav luag tsuas yog cov tshuaj uas ua rau nws poob phaus yam tsis muaj kev phom sij rau kev noj qab haus huv. Yog tias tom qab 6-8 lub lim tiam ntawm nws cov thawj coj nws tsis tuaj yeem ua kom tau txais ntawm tsawg ob peb phaus ntxiv - feem ntau, tus neeg muaj kev tsis txaus cov thyroid hormones. Kuaj ntshav rau tag nrho cov tshuaj hormones no, tsis txwv rau TSH. Qhov ntsuas tseem ceeb tshwj xeeb yog T3 pub dawb. Tom qab ntawd sab laj nrog endocrinologist.

Hauv cov neeg uas hloov mus rau, qhov tshwm sim ntawm kev poob phaus nws muaj nuj nqi ntau dua. Coob leej hauv lawv qhov kev tshuaj xyuas sau tias lawv tau tswj kom poob 15 kg lossis ntau dua. Koj yuav tsum haus cov tshuaj metformin txuas ntxiv kom tswj qhov ua tiav tau. Yog tias koj tsum tsis noj cov tshuaj no, ces qee feem ntawm qhov phaus ntxiv yog qhov yuav rov qab los.

Elena Malysheva ua cov tshuaj metformin uas nrov los ua kev kho mob rau cov laus, tab sis nws tsis txhawb nws ua kev kho mob rau cov rog. Nws feem ntau pom zoo kom nws pluas noj kom yuag, thiab tsis yog qee yam tshuaj noj. Txawm li cas los xij, cov zaub mov no muaj ntau cov khoom noj uas ntau dhau nrog cov carbohydrates. Lawv nce qib ntawm cov kua dej hauv cov ntshav thiab yog li thaiv kev tawg ntawm cov rog hauv lub cev.

Cov ntaub ntawv hais txog kev kho mob ntshav qab zib thiab poob phaus, uas tshaj tawm los ntawm Elena Malysheva, yog rau feem ntau tsis muaj tseeb, tsis muaj hnub nyoog.

Yuav hloov cov metformin li cas yog tias nws tsis pab muaj ntshav qab zib lossis ua rau mob plab zawv?

Metformin tsis yooj yim los hloov nrog qee yam, nws yog nyob rau hauv ntau txoj kev uas ib txwm siv yeeb tshuaj. Txhawm rau kom tsis txhob mob raws plab, koj yuav tsum noj tshuaj nrog zaub mov, pib nrog kev noj tshuaj txhua hnub thiab maj mam ntxiv. Koj tseem tuaj yeem sim hloov ib ntus ntawm cov ntsiav tshuaj ib txwm mus rau kev noj tshuaj ntev. Yog tias cov tshuaj metformin tsis txo cov ntshav qab zib txhua - nws yog qhov ua tau tias tus neeg mob hnyav ntshav qab zib hom 2, uas tau hloov mus ua hom ntshav qab zib 1. Hauv qhov no, koj yuav tsum maj nrawm pib txhaj tshuaj insulin, tsis muaj tshuaj yuav pab tau.

Hauv cov ntshav qab zib, metformin feem ntau ua rau cov piam thaj qis dua, tab sis tsis txaus. Hauv qhov no, nws yuav tsum tau ntxiv nrog kev txhaj tshuaj ntawm insulin.

Nco qab tias cov neeg nyias ib txwm tsis muaj txiaj ntsig noj cov tshuaj ntshav qab zib. Lawv yuav tsum hloov mus rau cov insulin tam sim ntawd. Kev teem sij hawm ntawm kev kho tshuaj insulin yog ib qho teeb meem loj, koj yuav tsum to taub nws. Kawm cov lus hais txog insulin hauv lub xaib no, sab laj nrog koj tus kws kho mob. Ua ntej tshaj plaws, mus rau. Yog tsis muaj nws, kev tswj kab mob zoo yog tsis yooj yim sua.

Metformin (dimethylbiguanide) - cov tshuaj tiv thaiv kab mob rau kev siv sab hauv, uas belongs rau cov chav kawm ntawm biguanides. Txij nkawm Metformin Nws muaj feem xyuam nrog kev muaj peev xwm ntawm cov tshuaj nquag ua rau inhibit gluconeogenesis hauv lub cev. Cov tshuaj muaj zog cuam tshuam txoj kev thauj cov xaim hluav taws xob ntawm txoj hlab ua pa ntawm mitochondria. Qhov no ua rau qhov kev txo qis hauv cov concentration ntawm ATP sab hauv lub hlwb thiab kev txhawb nqa glycolysis los ntawm kev ua pa oxygen. Raws li qhov txiaj ntsig ntawm no, cov piam thaj kev nkag mus rau hauv cov hlwb los ntawm qhov chaw tso tawm ntxiv, thiab kev tsim cov lactate thiab pyruvate hauv lub siab, plab hnyuv, adipose thiab cov leeg nqaij nce ntxiv. Glycogen khw muag khoom hauv lub siab ua haujlwm hauv lub siab kuj tseem poob qis. Nws tsis ua rau teebmeem hypoglycemic, vim nws tsis ua rau lub zog insulin ntau lawm.

Txo cov txheej txheem ua haujlwm oxidation thiab txwv tsis pub tsim cov khoom siv roj dawb. Tawm tsam keeb kwm yav dhau los ntawm kev siv cov tshuaj, kev hloov pauv ntawm cov chaw muag tshuaj ntawm cov tshuaj insulin yog vim muaj qhov txo qis ntawm qhov sib piv ntawm cov tshuaj insulin ua rau muaj cov tshuaj insulin dawb. Ib qho kev nce ntxiv ntawm cov insulin / proinsulin piv kuj raug kuaj pom. Vim yog lub tshuab ntawm kev ua ntawm cov tshuaj, muaj qhov txo qis hauv cov piam thaj hauv ntshav cov ntshav tom qab noj zaub mov, qhov taw qhia tseem ceeb ntawm cov piam thaj kuj txo. Vim tias qhov tseeb hais tias cov tshuaj tsis txhawb kev tsim tawm ntawm insulin los ntawm beta hlwb ntawm cov txiav, nws nres hyperinsulinemia, uas yog suav tias yog ib qho tseem ceeb tshaj plaws hauv kev nce lub cev hnyav hauv ntshav qab zib thiab kev nce qib ntawm cov teeb meem vascular. Kev txo qis hauv cov piam thaj yog vim muaj kev txhim kho kev nqus ntawm cov piam thaj los ntawm cov leeg nqaij thiab ib qho nce ntawm qhov nkag ntawm lub qhov tso tshuaj insulin. Hauv cov neeg muaj kev noj qab haus huv (tsis muaj ntshav qab zib) thaum noj cov tshuaj metformin, yuav tsis pom muaj qabzib tsawg nyob rau hauv. Metformin pab txo qhov hnyav hauv lub cev hauv kev rog thiab ntshav qab zib los ntawm kev qab los noj mov, txo qhov nqus ntawm cov piam thaj los ntawm cov khoom noj hauv lub plab zom mov thiab txhawb anaerobic glycolysis.

Metformin kuj tseem muaj cov nyhuv fibrinolytic vim yog kev txwv tsis pub PAI-1 (cov nqaij mos plasminogen activator inhibitor) thiab t-PA (cov nqaij mos plasminogen activator).
Cov tshuaj txhawb cov txheej txheem ntawm biotransformation ntawm qabzib rau hauv glycogen, ua kom ntshav ncig hauv cov ntshav hauv daim siab. Cov cuab yeej Hypolipidemic: txo cov qib LDL (qis lipoproteins tsawg), triglycerides (los ntawm 10-20% txawm tias pib nce 50%) thiab VLDL (lipoproteins ntau ntom tsawg). Vim tias cov teeb meem ntawm cov khoom noj hauv lub cev, metformin ua rau nce HDL (cov lipoproteins ntau ntom ntom) los ntawm 20-30%.

Cov tshuaj tiv thaiv kev txhim kho ntawm kev loj hlob ntawm cov nqaij ntshiv ntawm cov hlab phab ntsa. Nws muaj cov txiaj ntsig zoo ntawm lub plawv thiab tiv thaiv cov tsos mob ntawm tus mob ntshav qab zib angiopathy.

Tom qab kev tswj hwm ntawm qhov ncauj, qhov siab tshaj plaws ntawm cov tshuaj yeeb dej caw tau mus txog hauv cov ntshav ntshav tom qab 2.5 teev. 6 teev tom qab noj cov ntsiav tshuaj, kev nqus ntawm cov khoom ua kom nquag plias los ntawm cov tshuaj xaus, uas nrog cov lus txo qis hauv plasma concentration metformin Cov. Thaum noj cov tshuaj pom zoo tom qab 1-2 hnub, cov tshuaj ntau ntawm metformin pom nyob hauv cov ntshav ntshav tsis pub dhau 1 μg / ml lossis tsawg dua.

Yog tias koj noj cov tshuaj thaum noj zaub mov, tom qab ntawd muaj qhov txo qis hauv kev nqus ntawm metformin los ntawm cov tshuaj. Metformin tsuas yog sau ntau ntxiv hauv cov phab ntsa ntawm lub raj plab zom mov: hauv qhov me me thiab duodenum, lub plab, ntxiv rau cov qaub ncaug thiab lub siab. Ib nrab-lub neej yog kwv yees li 6.5 teev. Nrog rau kev siv sab hauv ntawm metformin, qhov tsis txaus ntseeg ntawm cov neeg muaj kev noj qab haus huv yog kwv yees li 50-60%. Tsawg me ntsis khi rau cov ntshav protein.Kev siv cov tubular ua kom tso pa tawm thiab glomerular pom, nws yog tawm los ntawm ob lub raum los ntawm 20 txog 30% ntawm cov tau txhaj tshuaj (tsis hloov, vim tias, tsis zoo li formin, nws tsis yog metabolized). Yog tias lub raum tsis ua haujlwm, lub raum kev txiav txim siab txo qis hauv kev faib ua ke rau creatinine qhov kev ua haujlwm, yog li ntawd, cov ntshav plasma qhov siab thiab ib nrab ntawm lub neej ntawm metformin nce los ntawm lub cev, uas tuaj yeem ua rau tsub zuj zuj ntawm cov tshuaj nquag hauv lub cev.

Txoj kev ntawm daim ntawv thov

Kev lees txais cov tshuaj los ntawm cov laus yog nqa tawm tsuas yog coj mus rau hauv tus account cov ntaub ntawv ntawm kev soj ntsuam tas li ntawm lub raum ua haujlwm.
Kev saib xyuas txhua yam kev ua haujlwm yog pom 2 asthiv tom qab siv cov tshuaj.

Yog tias koj yuav tau mus Metformin nrog lwm qhov hypoglycemic qhov ncauj ntawm tus neeg sawv cev, tom qab ntawd cov tshuaj dhau los yuav tsum tau txiav tawm, thiab tom qab ntawd pib kho nrog Metformin nyob rau hauv cov tshuaj pom zoo.

Nrog kev sib xyaw ntawm insulin thiab Metformin, cov tshuaj ntawm cov tshuaj insulin tsis hloov pauv hauv thawj 4-6 hnub. Nyob rau hauv lub neej yav tom ntej, yog tias nws yuav tsim nyog, cov koob tshuaj insulin yog maj maj - dhau ob peb hnub tom ntej los ntawm 4-8 IU. Yog tias tus neeg mob tau txais ntau dua 40 IU ntawm cov tshuaj insulin ib hnub, tom qab ntawd qhov kev txo qhov hno tsawg dua thaum siv Metformin tsuas yog coj hauv tsev kho mob xwb, vim nws xav tau kev saib xyuas zoo.

Kev cuam tshuam nrog lwm yam tshuaj

Angiotensin-converting factor inhibitors, β2-adrenergic antagonists, monoamine oxidase inhibitors, cyclophosphamide derivatives thiab cyclophosphamide nws tus kheej, clofibrate derivatives, non-steroidal anti-inflammatory tshuaj thiab oxytetracycline tuaj yeem ua rau muaj txiaj ntsig hypoglycemic effect ntawm Metformin. Kev siv tshuaj tiv thaiv lossis tso quav rau cov tshuaj iodine uas muaj cov tshuaj tiv thaiv kev xoo hluav taws xob tuaj yeem ua rau lub raum tsis ua haujlwm, vim tias Metformin pib nthuav tawm, uas ua rau muaj kev pheej hmoo ntawm lactic acidosis. Cov tshuaj raug tso tseg ua ntej, thaum lub sijhawm thiab rau 2 hnub tom qab xoo hluav taws xob nrog kev saib xyuas intravascular ntawm cov neeg sawv cev sib piv uas muaj iodine. Tom qab qhov no, Metformin txoj kev kho tsis tuaj yeem rov qab tau kom txog thaum txoj haujlwm ntawm lub raum tau rov tshuaj xyuas dua li qub.

Cov tshuaj neuroleptic chlorpropamazine hauv ntau qhov ntau ntxiv ua kom cov ntshav qabzib muaj zog thiab txwv tsis pub cov kua dej tawm, uas tej zaum yuav tsum muaj qhov nce ntxiv ntawm Metformin (ua haujlwm tsuas yog tswj hwm cov ntshav qabzib).
Kev sib xyaw ntawm danazol nrog Metformin , txij li hyperglycemia yog ua tau. Amiloride, morphine, quinine, vancomycin, quinidine, cimetidine, triamteren, ranitidine, procainamide, nifedipine (zoo li lwm cov calcium channel inhibitors), trimethoprim, famotidine thiab digoxin yog zais los ntawm cov raum leeg. Nrog rau kev siv tib yam ntawm Metformin, lawv muaj peev xwm sib tw rau cov tubular thauj cov tshuab, yog li nrog siv ntev lawv ua rau muaj qhov nce ntawm plasma concentration ntawm cov tshuaj nquag ntawm cov tshuaj los ntawm 60%.

Guar thiab cholestyramine inhibit qhov nqus ntawm cov khoom nquag ntawm Metformin ntsiav tshuaj, uas yog nrog los txo qis hauv nws cov hauj lwm zoo.

Cov tshuaj no yuav tsum tau noj tsuas yog ob peb teev tom qab kev tswj hwm Metformin Cov. Cov tshuaj txhim kho qhov cuam tshuam ntawm cov tshuaj tiv thaiv sab hauv ntawm cov chav kawm ua haujlwm ntawm chav dej.

Yeem

Kev nqa tshuaj rau cov neeg mob hnub nyoog 60 xyoo thiab tshaj saud tsis pom zoo yog tias lawv ua lub cev hnyav. Qhov no tuaj yeem ua rau cov kab mob lactic acidosis. Cov tshuaj creatinine qib yuav tsum tau txiav txim siab ob qho tib si ua ntej kev kho mob thiab kev kho mob lub sijhawm tsis tu ncua (ib xyoos ib zaug ntawm cov nqi ib txwm muaj). Yog tias thawj zaug kev pib creatinine yog siab dua li ib txwm lossis siab dua, ces kev qhia txog kev kawm pom zoo yog 2-4 zaug hauv ib xyoos.Cov neeg laus yuav muaj qhov kev ua asymptomatic ntawm lub raum tsis ua haujlwm, yog li ntawd, lawv kuj txiav txim siab creatinine qib 2-4 zaug hauv ib xyoos.
Nrog rau kev rog dhau hoom, koj yuav tsum yoog kom noj cov zaub mov muaj zog.

Thaum noj cov tshuaj, cov neeg mob yuav tsum ua raws li kev noj haus ib qho zuj zus, uas yuav siv mus rau qhov tseeb kev faib tawm ntawm cov zaub mov carbohydrate hauv cov zaub mov nruab hnub. Thaum pib ntawm kev noj tshuaj diuretics, tshuaj tsis-steroidal tshuaj tiv thaiv thiab tshuaj tiv thaiv mob, tuaj yeem muaj qhov tshwm sim xws li lub raum tsis ua haujlwm. Hauv cov neeg mob no, Metformin yuav tsum siv nrog ceev faj hauv kev sib txuas nrog kev tsis tuaj yeem ua haujlwm hauv lub raum.
Tom qab kev phais, kev kho tshuaj thim rov qab tom qab 2 hnub. Ua ntej lub sijhawm no, Metformin yuav tsum tsis txhob ua. Kev kuaj kab mob ntshav qab zib soj ntsuam chav kawm ntshav qab zib tau ua tiav kom zoo thiab tsis tu ncua, saib xyuas qee lub sijhawm.

Kuv puas tuaj yeem noj tshuaj metformin yam tsis tau sab laj nrog kws kho mob?

Cov tshuaj Metformin tau faib rau hauv cov khw muag tshuaj tsis muaj tshuaj, yog li ib tus neeg tuaj yeem yuav lawv yam tsis tas mus ntsib kws kho mob ua ntej. Ua ntej siv thawj zaug ntawm cov tshuaj, koj yuav tsum paub tseeb tias tus neeg mob tsis muaj contraindications rau nws siv. Nws yog ib qho zoo tshaj los kuaj ntshav rau qhov no. Nws yuav ntsuas qhov ua tau zoo ntawm daim siab thiab lub raum. Xws li kev xeem yuav tsum tau coj tsawg kawg 1 zaug hauv 6 lub hlis. Nws kuj tseem ceeb kom tswj cov qib ntshav hauv cov ntshav thiab qib ntshav siab, uas yuav ua rau nws tiv thaiv txoj kev loj hlob ntawm cov kab mob plawv.

Qhov siab tshaj plaws txhua hnub cov tshuaj metformin yog ntau npaum li cas?

Ob qho tib si rau kev poob phaus thiab rau kev kho mob ntshav qab zib hom 2, tus neeg mob tau sau tshuaj rau txhua hnub yog 2550 mg ntawm metformin. Hauv qhov no, ib tus neeg yuav tsum noj 3 lub tshuaj ntawm 3 zaug nyob rau ib hnub. Qhov ntau ntawm cov tshuaj yog 850 mg.

Yog tias cov tshuaj ntev-tso tawm siv rau kev kho mob, ces qhov siab tshaj plaws niaj hnub noj yog 2000 mg. Txhawm rau ua qhov no, noj 4 ntsiav tshuaj ntawm 500 mg ntawm cov tshuaj Glucofage Ntev ua ntej yuav mus pw.

Thawj koob ntawm cov tshuaj yuav tsum muaj tsawg: 500 lossis 850 mg. Tom qab ntawd, taug qab cov tshuaj tiv thaiv ntawm lub cev, ntau npaum li cas yog maj mam nce. Kev hloov qeeb qeeb yuav tiv thaiv kev txhim kho ntawm cov mob nyhav ntawm lub plab zom mov.

Yog tias ib tug neeg txiav txim siab siv tshuaj metformin los ua kom muaj kev cia siab ntau dua, nws pom zoo kom soj ntsuam qhov tshuaj ntau npaum li 500-1700 mg ib hnub, tab sis tsis muaj ntxiv.

Cov nyhuv ntev li cas?

Ntev ntev metformin ua haujlwm rau 8-9 teev. Cov tshuaj metformin ua tau tshwj xeeb tau khaws cia nws cov txiaj ntsig rau tsis pub dhau 6 teev. Yog tias cov koob tshuaj ntxiv tau noj ua ntej lub sijhawm ntawm koob dhau los, koj yuav tsum tsis txhob txhawj xeeb. Nws tsis muaj teeb meem rau kev noj qab haus huv. Nws yog ib qho tseem ceeb kom paub meej tias tsis muaj kev noj ntau dhau. Rau qhov no, cov tshuaj yuav tsum tsis txhob noj nyob rau hauv ib qho nyiaj tshaj qhov koob tshuaj txhua hnub.

Tshuaj metformin tuaj yeem ua ke nrog statins?

Metformin tuaj yeem siv nrog statins, uas pab txo cov ntshav hauv cov ntshav hauv cov ntshav. Yog tias tib lub sij hawm ib tug neeg ua raws kev noj haus, tom qab ntawd nws yuav ua kom ib txwm ua tsis tau roj, tab sis kuj triglycerides thiab coefficient ntawm atherogenicity. Ntxiv mus, noj cov tshuaj metformin thiab ua raws kev noj haus ntau dhau sijhawm tuaj yeem ua rau koj tsum tsis noj statins. Cov ntawv qhia zaub mov nrog cov ntsiab lus tsis muaj carbohydrate yuav tso cai rau koj kom tshem tawm cov kua ntau dhau ntawm lub cev, tshem tawm ntawm edema, thiab txo cov ntshav siab. Yog li, cov kws kho mob pom zoo maj mam txo cov tshuaj rau kev kho mob plawv pathologies, thiab tom qab ntawd koj tuaj yeem tso lawv tseg. Nws yog qhov ua tau tias nws yuav tuaj yeem nres kev kho mob nrog cov tshuaj diuretic.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj yog nyob rau hauv daim ntawv ntawm ntsiav tshuaj, uas yog coated nrog ib zaj duab xis daim nyias nyias.500 mg thiab 850 mg ntsiav tshuaj yog tsim. Lub blister tuaj yeem yog 30 lossis 120 pcs.

Cov tshuaj muaj pes tsawg leeg muaj cov tshuaj ua kom ua metformin, nrog rau cov tshuaj ntxiv: cov hmoov txhuv nplej siab, magnesium stearate, talc.

Cov chaw soj ntsuam thiab kws tshuaj: qhov ncauj tshuaj hypoglycemic.

Dab tsi pab metformin?

Nws yog tshuaj rau cov neeg laus uas muaj hom 1 thiab ntshav qab zib hom 2. Metformin yog siv los ntxiv rau kev kho mob tseem ceeb nrog insulin lossis lwm yam tshuaj tiv thaiv kab mob, nrog rau kev kho mob monotherapy (rau hom 1 ntshav qab zib mellitus nws tsuas yog siv ua ke nrog insulin).

Pharmacological kev txiav txim

Metformin inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm cov hnyuv, txhim kho kev siv ntu ntawm cov piam thaj, thiab tseem ua rau kev nkag siab ntawm cov ntaub so ntswg mus rau insulin. Nws tsis cuam tshuam qhov zais cia ntawm insulin los ntawm beta hlwb ntawm tus txiav, tsis ua rau kev tsis tuaj yeem tshwm sim.

Txo cov theem ntawm triglycerides thiab qis linoproteins hauv cov ntshav. Stabilizes lossis txo qhov hnyav lub cev. Nws muaj cov nyhuv fibrinolytic vim yog kev tsuj tawm ntawm cov nqaij plasminogen activator inhibitor.

Lub Npe Tsis Yog Neeg Tsis Muaj Npe

Cov ntsiav tshuaj, 500 mg, 850 mg thiab 1000 mg

Ib qho 500 mg ntsiav tshuaj ntim:

cov tshuaj heev : metformin hydrochloride - 500 mg.

hauvtus zam : microcrystalline cellulose, croscarmellose sodium, dej lim, povidone (polyvinylpyrrolidone), magnesium stearate.

Ib 850 mg ntsiav tshuaj muaj:

cov tshuaj heev : metformin hydrochloride - 850 mg.

Ib qho 1000 mg ntsiav tshuaj muaj:

nquag cov tshuaj yeeb dej caw: metformin hydrochloride - 1000 mg.

auxkho kom zoo tshuaj: microcrystalline cellulose, croscarmellose sodium, dej lim, povidone (polyvinylpyrrolidone), magnesium stearate.

500 mg ntsiav tshuaj - puag ncig tiaj-cylindrical ntsiav tshuaj ntawm cov xim dawb lossis yuav luag xim dawb nrog kev pheej hmoo ntawm ib sab thiab ib chamfer ntawm ob sab.

Cov ntsiav tshuaj 850 mg, 1000 mg - oval biconvex ntsiav tshuaj ntawm cov xim dawb lossis yuav luag dawb nrog kev pheej hmoo ntawm ib sab.

Cov chaw muag tshuaj

Tom qab cov neeg siv qhov ncauj, metformin yog nqus tau ntawm txoj hnyuv mus tag nrho. Kev tsis raug cai ntawm bioavailability yog 50-60%. Qhov siab tshaj plaws (Cmax) (kwv yees li 2 μg / ml lossis 15 μmol) hauv ntshav tau txog tom qab 2.5 teev.

Nrog kev noj ib txhij, kev nqus ntawm metformin yog txo thiab qeeb.

Metformin tau faib sai sai hauv cov ntaub so ntswg, kev xyaum ua haujlwm tsis khi rau cov ntshav protein. Nws yog metabolized mus rau ib tug kawm ntawv uas tsis muaj zog thiab tawm los ntawm ob lub raum. Kev tshem tawm ntawm metformin hauv cov ntsiab lus noj qab haus huv yog 400 ml / min (4 zaug ntau dua li creatinine tshem tawm), uas qhia tias muaj cov kwj dej muaj kuab paug. Ib nrab-lub neej yog kwv yees li 6,5 teev. Nrog raum tsis ua haujlwm, nws nce, muaj kev pheej hmoo ntawm kev txuam nrog cov tshuaj.

Metformin txo hyperglycemia yam uas tsis ua rau kev txhim kho ntshav qab zib hauv lub ntsej muag. Tsis zoo li sulfonylurea derivatives, nws tsis txhawb kev tiv thaiv insulin secretion thiab tsis muaj cov nyhuv hypoglycemic hauv cov neeg noj qab haus huv. Tsub qhov rhiab heev ntawm peripheral receptors rau insulin thiab kev siv cov kua nplaum los ntawm lub hlwb. Nws inhibits gluconeogenesis nyob rau hauv daim siab. Ncua kev nqus ntawm cov carbohydrates hauv cov hnyuv. Metformin stimulates glycogen synthesis los ntawm kev ua ntawm glycogen synthase. Tsub kom muaj peev xwm thauj tau txhua yam ntawm cov khoom thauj ua kua roj ntau dua.

Tsis tas li ntawd, nws muaj txiaj ntsig zoo rau lipid metabolism: nws txo cov ntsiab lus ntawm cov roj (cholesterol) tag nrho, cov lipoproteins tsawg thiab triglycerides.

Thaum noj cov tshuaj metformin, tus neeg mob lub cev hnyav dua li qub tseem ruaj khov lossis txo qis.

Kev ntsuas rau siv

Hom 2 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog rau cov neeg mob rog rog, nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo thiab ua si lub cev:

Hauv cov laus, raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg lub qhov ncauj hypoglycemic, lossis nrog insulin,

Hauv cov menyuam yaus txij thaum 10 xyoo los ua kev kho monotherapy lossis kev sib xyaw nrog insulin.

Sim daim ntawv thov

Tsis ntev los no, Metformin tau siv ntau dua hauv kev sim tshuaj polycystic zes qe menyuam, cov kab mob rog tsis muaj cawv haus cawv, kev muaj menyuam ntxov thiab lwm yam kab mob cuam tshuam nrog kev tiv thaiv insulin, xws li acromegaly, hypercorticism.

Tsis muaj cov ntaub ntawv qhia tseeb thiab kev tshawb fawb ntawm kev txiav txim siab txog qhov tshwm sim ntawm Metformin rau cov kab mob saum toj no, txawm li cas los xij, qee tus kws kho mob tau lees tias tom qab kev tswj hwm ntawm Metformin, qib ntawm cov piam thaj thiab insulin tsawg dua, tab sis qhov no tsis txaus kom suav cov tshuaj nyob rau hauv cov kev cai coj los kho tus mob.

Metformin rau polycystic ovary rau kev kho mob ntawm ovulation stimulation tseem tsis tau ua haujlwm, vim tias ntau cov kev tshawb fawb ntawm nws cov nyhuv ntawm kev ua me nyuam tau ua tiav ntau yam tsis tiav. Qee tus kws kho mob, siv Metformin rau polycystic zes qe menyuam thiab cov ntshav qab zib hauv qab, ceeb toom txog kev muaj menyuam hauv plab rau cov neeg mob noj Metformin, tsis zoo li cov uas tsis. Txawm li cas los xij, clomiphene yog chav siv los txhawb kev ovulation.

MD Anderson Cancer Center ua txoj kev tshawb fawb loj uas pom qhov cuam tshuam ntawm Metformin txog kev tiv thaiv tus mob qog noj ntshav. Cov kev tshawb pom ntawm txoj kev tshawb pom tau qhia tias 62% kev txo qis hauv kev pheej hmoo ntawm kev mob qog nqaij hlav hauv kev noj qab haus huv ntawm cov neeg tuaj kawm uas coj Metformin piv rau cov pab pawg neeg mob uas tsis tau noj. Qhov no coj mus rau pib ntawm kev tshawb fawb tshiab thiab kev txhim kho ib txoj haujlwm rau kev tiv thaiv tus mob qog noj ntshav.

Metformin Kev Tawv Khaub

Niaj hnub no nws tau dhau los ua neeg nyiam ntawm cov neeg rog thiab rog dhau los yam tsis muaj ntshav qab zib noj tshuaj Metformin uas yog qhov ua rau poob phaus. Muaj ib chav kawm ntawm kev kho mob nrog Metformin thiaj li yuav hlawv cov rog nyhav dhau heev lawm. Endocrinologist tsis qhia lawv cov neeg mob noj Metformin yam tsis muaj ntshav qab zib mellitus thiab txo qis hauv rhiab ntawm cov hlwb rau insulin. Cov lus qhia rau kev siv sau txog nws. Tab sis feem ntau, cov neeg mob ua qhov no yam tsis tau sab laj nrog kws kho mob. Nov yog ib qho kev coj ua txaus ntshai heev.

Tsis ua raws li cov khoom noj tsim nyog nrog cov piam thaj hauv qab zib, qhov tsis lees paub ntawm qhov xav tau ntawm cov tshuaj, tuaj yeem ua rau ntau cov kev phiv, qhov no yog, ua ntej. Thib ob, nws ua pov thawj tias Metformin tsis cuam tshuam rau cov ntshav qabzib hauv cov neeg noj qab haus huv, uas txhais tau hais tias tsuas yog muaj cov tshuab ua kom txo qis qib ntawm cov roj ntsha ua haujlwm hauv qhov no.

Metformin rau kev poob phaus, tshwj xeeb yog tsis muaj kws kho mob sau, yog contraindicated.

Tus kws kho mob tuaj yeem sau nws tsuas yog mob ntshav qab zib lossis thaum muaj tshuaj tiv thaiv insulin. Tab sis txawm hais tias qhov no, kev noj haus thiab kev tawm dag zog muaj txiaj ntsig zoo dua li cov tshuaj uas Metformin yog. Cov lus qhia rau kev siv tsis piav qhia txog kev siv tshuaj rau qhov poob phaus.

Cov tsos mob thiab txaus ntshai ntawm kev haus luam yeeb dhau lawm

Kev noj tshuaj ntau tshaj ntawm Metformin yog qhov tsis tshua muaj neeg pom. Hauv cov ntawv nyeem, koj tuaj yeem nrhiav cov lus piav qhia ntawm tsuas yog ib kis thaum noj cov tshuaj ntawm koob tshuaj 75g. Nyob rau tib lub sijhawm, cov piam thaj hauv lub siab tsis hloov, tab sis cov lactic acidosis tau tsim - qhov xwm txheej txaus ntshai heev uas qib ntawm lactate hauv cov ntshav yuav siab dua 5 mmol / l. Thawj qhov tsos mob yuav yog:

kiv taub hau
mob taub hau kom txog rau thaum pib ntawm mob taub hau,
npaws
kev cuam tshuam ntawm kev ua pa
xeev siab
ntuav
zawv plab
mob plab
spasms hauv cov leeg ntawm nqaj.

Cov mob hnyav heev yuav ua rau lub chaw lag luam tsis xeev rov qab thiab qhov xav tau txuas rau lub tshuab ua pa.

Thaum muaj cov tsos mob zoo li no, nws yog ib qho tsim nyog yuav tsum tau mus pw hauv tsev kho mob tam sim ntawd thiab ua tiav txhua qhov kev ntsuas tsim nyog uas yuav ua rau pom qib ntawm lactate, pyruvate thiab lawv qhov sib piv hauv cov ntshav.

Rau qhov kev tshem tawm sai sai ntawm Metformin tawm ntawm lub cev, nws yog ib qho laj thawj siv hemodialysis.

Metformin thaum cev xeeb tub thiab lactation

Thaum cev xeeb tub, Metformin nruj me ntsis raug pom zoo. Nws tuaj yeem thiab yuav tsum tau noj ua ntej cev xeeb tub rau cov poj niam uas muaj ntshav qab zib hom 2 thiab kev rog rog txhawm rau txhawm rau txhawm rau txhawm rau muaj kev pheej hmoo thiab ua kom yuag, tab sis cov tshuaj yuav tsum tsis ua ntxiv thaum muaj menyuam. Ntau tus kws kho mob tseem tau sau npe rau Metformin thaum thawj peb lub hlis, tab sis qhov no yog fraught nrog cov teeb meem rau tus me nyuam hauv plab.

Tom qab, cov menyuam yaus uas lawv niam noj Metformin thaum cev xeeb tub yuav muaj kev pheej hmoo ntawm kev rog thiab mob ntshav qab zib. Yog li, nws yog qhov tseeb tias tus poj niam yuav tsum siv tshuaj Metformin thaum cev xeeb tub tsuas yog thaum tsim nyog kiag thiab tsis muaj peev xwm hloov nrog lwm cov tshuaj.

Txog kev npaj rau cev xeeb tub, Metformin khwv tau lub npe “qhov tseem ceeb” ntawm cov poj niam muaj ntshav qab zib, rog thiab lub cev ntawm zes qe menyuam. Cov poj niam rog yog cov muaj kev txom nyem ntxiv lawm tshob. Metformin pab ua kom lub cev faib cov piam thaj thiab txo qib ntawm cov rog rog, thiaj li ua rau muaj cov keeb kwm keeb kwm hormonal thiab rov ua kom lub cev ntas ib txwm muaj.

Thaum pub niam mis, nws tseem tsim nyog nres siv Metformin.

Metformin rau menyuam yaus

Nyob rau lub sijhawm xyoo pua nees nkaum, mob ntshav qab zib hom II hauv cov menyuam yaus thiab cov tub ntxhais hluas yog cov muaj ntau dua. Ntxiv mus, tus kab mob no tsis hla cov menyuam yaus ntawm cov haiv neeg sib txawv thiab pab pawg. Cov menyuam yaus thoob plaws ntiaj teb yog qhov muaj kev rog thiab poob qis ntawm cov nqaij rhiab rau insulin. Tsis ntev tas los no, ntau lub program tau tsim rau txoj kev kho mob tsis muaj tshuaj ntawm cov menyuam yaus uas muaj cov ntshav qabzib mob ntshav insulin, uas suav nrog kev noj zaub mov zoo thiab kev tawm dag zog. Txawm li cas los xij, ntau thiab ntau dua yuav tsum muaj chaw rau kev kho mob. Kev ua neej nyob rau siab luv thiab ib qho zaub mov tsis zoo uas muaj suab thaj thiab rog ntau ua rau lub ntsej muag rov qab muaj kab mob.

Metformin tau pib tawm tsam me nyuam yaus hnub nyoog qis dua 15 xyoos. Tom qab kev tshawb fawb tsis ntev los no los ntawm Asmeskas cov kws kho mob, nyob rau hauv uas cov menyuam yaus thiab tub ntxhais hluas hnub nyoog 10-16 xyoo tau siv Metformin rau 16 lub lis piam, qhov kev poob qis tseem ceeb hauv cov roj ntsha dawb hauv cov ntshav, txo qis ntawm cov lipoproteins tsawg thiab tsawg kawg ntawm lipoproteins, triglycerides, thiab poob phaus. Ntawm cov kev mob tshwm sim, tsis pom tus mob hypoglycemia lossis lactic acidosis tau tshwm sim, tsis tshua muaj tshwm sim hauv daim ntawv qhia txog kev zawv plab lossis zawv plab tsis muaj kev cuam tshuam cov txiaj ntsig ntawm txoj kev tshawb no.

Cov txiaj ntsig ntawm kev siv Metformin hauv menyuam yaus tau muaj pov thawj, pib txij li 10 xyoo yam tsis muaj teeb meem loj, tab sis nrog cov txiaj ntsig zoo thiab yav tom ntej ua tiav kev tswj ntshav qab zib thiab txo cov koob tshuaj kom tsawg kawg nrog kev muaj peev xwm tshem tawm nws.

Kev cuam tshuam nrog lwm yam tshuaj

Kev siv cov Metformin raws li kev kho mob monotherapy tsis ua rau kev mob ntshav qab zib, tab sis nws yuav tsum ua tib zoo ua ke nrog sulfonylurea thiab insulin.

Qee yam tshuaj tuaj yeem txo qhov kev mob hypoglycemic ntawm Metformin thiab tshem tawm txoj kev kho mob: cov tshuaj hormones steroid, cov thyroid hormones, glycogen, adrenaline thiab lwm yam kev cuam tshuam ntawm cov receptors ntawm cov leeg hlwb, poj niam pw ua ke (estrogen thiab progesterone), nicotinic acid derivatives, diuretics, thiazide derivatives.

Kev siv cov Metformin nrog cawv yog sib xyaw kom nruj, vim tias ethanol tuaj yeem ua rau cov kab mob lactic acidosis ua ke nrog Metformin. Ua raws li cov tib lub ntsiab lus, txhua qhov kev npaj muaj ethanol tsis tuaj yeem lees ua ke nrog metformin. Lactic acidosis tuaj yeem tseem ua rau kev siv cov tshuaj iodine-yam muaj kev cuam tshuam nrog Metformin. Qee cov txheej txheem kuaj mob tsis tuaj yeem ua yam tsis muaj kev qhia ntawm kev sib piv nrog iodine, qhov no nws yog qhov yuav tsum tau ua, Metformin yuav tsum tso tseg rau 48 teev ua ntej thiab tom qab ua tiav.

Cov neeg mob uas siv tshuaj chlorpromazine yuav tsum tau txhaj tshuaj ntau ntxiv ntawm Metformin.Qhov no yog vim qhov tseeb tias chlorpromazine nyob rau hauv cov koob tshuaj loj loj tsim kev tsim cov tshuaj insulin.

Mis acidosis tuaj yeem tshwm sim thaum Metformin xyaw nrog cimetidine.

Metformin thiab Vitamin B12

Vitamit B12 lossis cyanocobalomin yog cov tshuaj uas tsim nyog rau hematopoiesis thiab kev ua haujlwm ntawm lub paj hlwb, ua tsaug rau nws cov protein yog synthesized hauv lub cev.

Nws kwv yees tias nrog kev siv lub sijhawm ntev ntawm Metformin, cov tshuaj cuam tshuam rau qhov nqus nyob rau hauv ileum ntawm cov vitamin no, uas ua rau maj mam txo qis hauv nws hauv cov ntshav. Hauv xyoo thib tsib ntawm kev nkag, qib B12 txo 5% rau xyoo 13 - los ntawm 9.3%.

Nws yuav tsum raug sau tseg tias qhov tsis txaus 9% tsis ua rau hypovitaminosis thiab kev txhim kho hemolytic tsis txaus, tab sis muaj kev pheej hmoo ntawm kev txhim kho yav tom ntej.

Kev tsis txaus B12 ua rau hemolytic anemia, uas txhais tau hais tias cov ntshav liab ua rau lub cev tsis muaj zog thiab muaj kev sib cav sib ceg hauv cov hlab ntshav. Qhov no ua rau txoj kev txhim kho anemia thiab jaundice. Cov tawv nqaij thiab cov xoos ua qog ua daj, tus neeg mob yws ntawm qhov tsis muaj zog, lub qhov ncauj qhuav, loog ntawm ob txhais ceg thiab caj npab, kiv taub hau, tsis qab los noj mov, thiab tsis muaj kev sib koom tes.

Txhawm rau txiav txim siab txog qib vitamin B12, koj yuav tsum kuaj ntshav dav dav kom pom cov duab thiab ntshav liab tsawg. Nrog B12 tsis muaj peev xwm hemolytic anemia, ntshav liab yuav loj dua li ib txwm muaj lub nucleus, ntshav yuav tsis muaj ntshav, thiab yuav tsis muaj bilirubin ntau ntxiv hauv kev tshuaj ntsuam biochemical ntawm cov ntshav.

Nws tsim nyog tsim nyog rau qhov tsis muaj cov vitamins B12 thaum noj cov tshuaj Metformin. Koj tus kws kho mob yuav sau ntawv muab tshuaj thiab cov vitamins haj.

Qhov kev lom zem txaus luag thiab lub laj thawj, tab sis kev kho B12 tsis muaj peev xwm yog qhov tseeb kuj tau nqa los ntawm kev tswj hwm cov vitamin, tsuas yog tso ntshav tawm.