Kev qhia paub ntxiv

Kev cai Extentsef Nws yog siv los kho kab mob kis los ntawm cov kab mob me me rau cov tshuaj:
- txo qis mob ntsws ua pa: mob ntsws thiab ua kom mob ntsws ntev, mob ntsws txhaws dej
- mob txeeb zig: pyelonephritis, cystitis, mob rwj thiab prostatitis
- kis ntawm daim tawv nqaij thiab cov nqaij mos,
- mob plab: kab mob peritonitis, mob hauv plab,
- cov kab mob gynecological,
- septicemia,
- txoj kev kho kom zoo rau febrile neutropenia,
- kab mob rau cov leeg mob.

Pharmacological cov tub ceev xwm / Cov thawj coj lom thiab lom

Tsefepim prignіchuмент synthes of enzymes ntawm cov kab mob klitini і ma є ntau hom ntawm cov qauv sau ntawv zoo thiab muaj cov kab mob tsis zoo. Cephepium yog qhov ua tau zoo heev rau hydrolysis ntawm b-lactamase, kev sib tw me ntsis tau pom nyob hauv lub xub ntiag ntawm b-lactamase, uas tau sau los ntawm cov keeb kwm chromosome, thiab shvidko nkag mus hauv cov kab mob hlwb-tsis zoo.

Tsefepіm nquag schodo ntawm xws li cov kab mob me me:

Cov Qauv Ntsuas aerobi:Dab Tsi Staphylococcus aureus uas Staphylococcus phaum mob (suav nrog shx shtami, scho tsim b-lactamase), іshi shti stafіlokokіv, suav nrog S. hominis, S. saprophyticus, Streptococcus pyogenes (pawg A streptococci), Tus kab mob Streptococcus agalactiae (Cov kab mob Streptococcus pab pawg B), Kab mob ntsws dej liab (incl. nrog shtami los ntawm nruab nrab style mus rau penicillin - IPC hom 0.1 rau 1 μg / ml), tag nrho b-hemolytic streptococci (pawg C, G, F), S. bovis (pawg D), pawg streptococci ViridansCov. (Bіlshіst straіnt enterokokіv, piv txwv li: Nkag mus rau hauv faecalis, с staphylococci, tiv taus methicylin, tiv taus tshuaj tua kab mob ntau dua cephalosporin, suav nrog cefepim),

Gram-negative aerobi:Pseudomonas spp ., suav nrog P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiella spp., suav nrogK. pneumoniae, K. oxytoca, K. ozaenae, Kab Mob Enterobacter spp., suav nrog E. cloacae, E. aerogenes, E. agolomeratus, E. sakazakii, Proteus spp., suav nrog P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp. anitratus lwoffi), Aeromonas hydrophila, Capnocytophaga spp., Citrobacter spp., suav nrog Tus kab mob C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. mob khaub thuas (suav nrog nrog shtami, los tsim beta-lactamase), H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis ( Branhamella catarrhalis) (suav nrog nrog shtami, los tsim b-lactamase), Neisseria gonorrhoeae (suav nrog nrog shtami, los tsim b-lactamase), Nessera meningitidis, Pantoea agglomerans (vіdomiy yak Enterobacter agglomerans), Providencia spp. (suav nrogP. rettgeri, P. stuartii), Salmonella spp., Serratia (suav nrog S. marcescens, S. liquefaciens), Shigella spp., Yersinia enterocolitica.

(Cefepim tsis tsaug zog Xanthomonas maltophilia thiab Pseudomonas maltophilia),

anaerobi:Bacteroides spp., B. melaninogenicus, nteg rau Bacteroides, Clostridium perfringens, Fusobacterium spp., Mobiluncus spp., Peptostreptococcus spp., Veillonella spp.

(Cefepim tsis tsaug zog Bacteroides fragilis і Clostridium difficile).

Qhov nruab nrab nruab nrab ntawm cefepima hauv plasma los ntawm cov xuaj moos qhib tom qab ib lub sijhawm ib zaug ntawm lub cev thiab kev tswj hwm intramuscular yog ntxias tawm ntawm lub rooj.

Ntshav siab nyob rau hauv ntshav (/g / ml) nrog sab hauv (tso dej) thiab sab hauv (txoj leeg ntshav) tshuaj

Cov chaw muag tshuaj

Cepepime inhibits lub synthesis ntawm cov kab mob cell cell phab ntsa enzymes thiab muaj qhov dav dav ntawm kev ua raws li ntau yam kab mob gram-zoo thiab gram-tsis zoo. Cepepime muaj peev xwm tiv taus hydrolysis los ntawm feem ntau b-lactamases thiab muaj kev sib txuam qis rau b-lactamases encoded los ntawm cov keeb kwm chromosomal, thiab nkag mus sai sai rau cov kab mob gram-tsis zoo cov kab mob.

Cepepime nquag ua si tawm tsam cov kab mob hauv qab no:

gram-zoo aerobesDab Tsi Staphylococcus aureus thiab Staphylococcus phaum mob ( suav nrog lawv cov tsiaj uas tau ua b-lactamase) lwm yam ntawm cov kab mob staphylococci, suav nrog S. hominis, S. saprophyticus, Streptococcus pyogenes (Cov pab pawg Streptococcus A), Tus kab mob Streptococcus agalactiae (Cov kab mob Streptococcus pab pawg B), Kab mob ntsws dej liab (suav nrog cov leeg nrog nruab nrab tsis kam rau penicillin - MIC los ntawm 0.1 txog 1 μg / ml), lwm yam b-hemolytic streptococci (pawg C, G, F), S. bovis (pawg D), pawg streptococci Viridans Cov. (Piv txwv li feem ntau ntawm enterococci, piv txwv li Nkag mus rau hauv faecalis, thiab methicillin-resistant staphylococci tiv taus cov tshuaj tua kab mob feem ntau cephalosporin, suav nrog cefepime)

gram tsis zoo aerobesPseudomonas spp ., suav nrog P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiella spp., suav nrog K. pneumoniae, K. oxytoca, K. ozaenae, Kab Mob Enterobacter spp., suav nrog E. cloacae, E. aerogenes, E. agolomeratus, E. sakazakii, Proteus spp., suav nrog P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp. Anitratus, lwoffi ) , Aeromonas hydrophila, Capnocytophaga spp., Citrobacter spp., suav nrog Tus kab mob C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. mob khaub thuas (suav nrog qee kev tsim cov beta-lactamase) H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis ( Branhamella catarrhalis ) (suav nrog b-lactamase uas ua cov leeg tawm) Neisseria gonorrhoeae (suav nrog cov mob uas tau ua b-lactamase) Nessera meningitidis, Pantoea agglomerans (paub li Enterobacter agglomerans) Providencia spp. (suav nrog P. rettgeri, P. stuartii ) Salmonella spp., Serratia (suav nrog S. marcescens , S. liquefaciens) Shigella spp., Yersinia enterocolitica .

(Caj fes tsis ua haujlwm txog ntau hom kab mob) Xanthomonas maltophilia thiab Pseudomonas maltophilia )

anaerobes:Bacteroides spp., B. melaninogenicus hais txog Bacteroides , Clostridium perfringens, Fusobacterium spp., Mobiluncus spp ., Peptostreptococcus spp., Veillonella spp.

(Ua noj tsis qab los nyob ntawm Bacteroides fragilis thiab Clostridium difficile ).

Qhov nruab nrab ntshav ntau ntawm cefepime ntawm txawv sijhawm tom qab ib leeg thiab txhaj tshuaj rau hauv lub rooj.

Plasma cefepime ntau (mcg / ml) nrog cov leeg (i / v) thiab intramuscular (i / m) tswj hwm

Txoj kev ntawm daim ntawv thov

cov leeg. Rau kev tswj cov dav hlau, ib qho tshuaj ib zaug ntawm cov tshuaj yog diluted hauv 5 lossis 10 ml ntawm isotonic sodium chloride tov, 5% kua nplaum tov lossis dej tsis huv rau kev txhaj tshuaj thiab txhaj tshuaj maj mam dhau 3 - 5 feeb.
Nrog cov kua dej txau ntawm cov tshuaj, 500 lossis 1000 mg yog diluted hauv 100 - 250 ml ntawm isotonic sodium chloride tov lossis 5% kua nplaum tov, kev tswj hwm yog nqa tawm tsawg kawg 30 feeb.

Rau cov laus.
Cov kab mob txeeb zig, mob sib khuav mus rau nruab nrab: 500 mg - 1 g tso ntshav lossis tso ntshav txhua 12:00
Cov kab mob sib kis, mob me mus rau me 1 mus rau txoj leeg ntshav lossis tso ntshav txhua 12:00
Cov mob hnyav: 2 g txhua 12:00
Muaj mob hnyav heev thiab ua rau tuag tau ntawm 2 g txhua 8:00
Hauv cov neeg mob uas lub raum lub raum tsis ua haujlwm (creatinine tshem tawm 60 2 g txhua 8:00 2 g txhua 12:00 1 g txhua 12:00 1 g txhua 12:00
30 - 50 Kev txhaj tshuaj ntau npaum li cas nyob ntawm kev tshem tawm creatinine
2 g txhua txhua 12:00 2 g txhua 24 teev 1 g txhua 24 teev 500 mg txhua 24 teev
11 - 29 2 g txhua 24 teev 1 g txhua 24 teev 500 mg txhua 24 teev 500 mg txhua 24 teev

Cov tub ceev xwm Pharmacological.

Cefepim prigny synthesis of enzymes ntawm cov kab mob klitini д ma ua ntau yam sib txawv ntawm cov kab mob gramopositive thiab gram-negative. Cephepium yog qhov ua tau zoo heev rau hydrolysis ntawm b-lactamase, muaj kev sib tw me me rau b-lactamase, nws yog encoded los ntawm cov keeb kwm chromosome, thiab nws yog tshwj xeeb tshaj tawm hauv cov kab mob hlwb-tsis zoo ntawm cov kab mob.

Tsefepіm nquag schodo ntawm xws li cov kab mob me me:

Cov Qauv Ntsuas aerobi:Dab Tsi Staphylococcus aureus uas Staphylococcus epidermidis (Nrog rau шхні shtami, scho tsim b-lactamase), thiab Shtami stafіlokokіv, suav nrog S. hominis, S. saprophyticus, Streptococcus pyogenes (pawg A streptococci), Tus kab mob Streptococcus agalactiae (streptococci pawg B), Kab mob ntsws dej liab (suav nrog tus qauv nrab ntawm cov yeeb yaj kiab txog penicillin - qhov tsawg kawg nkaus ntawm kev mloog yog 0.1 mus rau 1 μg / ml), b-hemolitic streptococci (pawg C, G, F), S. bovis (pawg D), pawg streptococci ViridansCov. (Bіlshіst strainіnterokokіv, piv txwv li Nkag mus rau hauv faecalis, с staphylococci tiv taus methicillin, tiv cov tshuaj tua kab mob ntau dua cephalosporin, suav nrog cefepim),

Gram-negative aerobi:Pseudomonasspp., suav nrog P. aeruginosa, P. putida, P. stutzeri, Escherichia coli, Klebsiellaspp., suav nrog K. pneumoniae, K. oxytoca, K. ozaenae, Enterobacter spp., suav nrog E. cloacae, E. aerogenes, E.agolomeratus, E. sakazakii, Proteusspp., suav nrog P. mirabilis, P. vulgaris, Acinetobacter calcoaceticus (subsp.anitratus lwoffi), Aeromonas hydrophila, Capnocytophagaspp., Citrobacterspp., suav nrog Tus kab mob C. diversus, C. freundii, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus ducreyi, H. mob khaub thuas (suav nrog nrog shtami, los tsim beta-lactamase), H. parainfluenzae, Hafnia alvei, Legionella spp., Morganella morganii, Moraxella catarrhalis (Branhamella catarrhalis) (suav nrog los ntawm shtami, scho tsim b-lactamase), Neisseria gonorrhoeae (suav nrog nrog shtami, scho tsim b-lactamase), Nesseramob hlwb, Pantoea agglomerans ( vidomy yak Cov kab mob Enterobacter agglomerans), Providencia spp. (suav nrog P. rettgeri, P. stuartii), Salmonella spp., Serratia (suav nrog S. marcescens, S. liquefaciens), Shigellaspp., Yersinia enterocolitica.

(Cefepim tsis tsaug zog Xanthomonas maltophilia і Cov kab mob pseudomonas maltophilia),

anaerobi:Bacteroides spp. , B. melaninogenicus, nteg rau Bacteroides, Clostridium perfringens, Fusobacterium spp., Mobiluncus spp., Peptostreptococcus spp., Veillonella spp. (Cefepim tsis tsaug zog Bacteroides fragilis і Clostridium difficile).

Qhov nruab nrab nruab nrab ntawm cefepima hauv plasma los ntawm cov xuaj moos qhib tom qab ib-sijhawm ua kev tswj hwm ib leeg ntawm lub rooj.

Ntshav siab nyob rau hauv ntshav (/g / ml) nrog sab hauv (tso dej) thiab sab hauv 'mob siab (tso ntshav raws ntshav)

Sich, zhovchі, peritoneal retinitis, hnoos qeev muaj cov leeg txha caj qaum, hnoos qeev, mob prostate, hnyuv tws thiab zhovnichny mikhury tseem muaj tshuaj kho kom haum xeeb ntawm cefepime.

Nyob rau lub sij hawm nruab nrab napivvidendenny cefepіmu nrog cov kab mob ua rau muaj hnub nyoog txog 2 xyoos. Hauv cov neeg muaj kev noj qab haus huv, vim li ntawd, qhov ntau npaum li 2 g tau muab tshuaj rau sab hauv nrog 8 xyoo, kav ntev li 9 hnub, kev txuam ntawm cov tshuaj hauv lub cev tsis tau thim tawm.

Cepepime metabolized rau N-methylpyrrolidine, thiab nws yog sai metabolized rau N-methylpyrolidine oxide. Qhov nruab nrab zagalny cl_rens los ua 120 ml / hv. Tsefepim tuaj yeem pom txawm tias vinyatkovo rau mahogany ntawm cov txheej txheem tsis tu ncua - qib tseem ceeb yog glomerular pom lub kaus mom (nruab nrab nirkovy tshem tawm - 110 ml / hv). Kwv yees li ntawm 85% ntawm qhov noj tawm ntawm cov tshuaj noj uas tsis pom tshiab, 1% N-methylpyrolidine, kwv yees li 6.8% ntawm N-methylpyrolidine oxide, thiab kwv yees li 2.5% ntawm kua zaub mov noj yog pom tseeb hauv rooj plaub. Lub suab ntawm cov nqaij nruab deg nrog cov ntshav ntshav ua tsawg dua 19% thiab tsis dag nyob rau hauv kev mloog zoo ntawm cov tshuaj hauv ntshav.

Rau cov neeg mob nrog 65 views ntawm kev coj ua, lawv tsis tas yuav kho qhov koob tshuaj rau cefepim, thiab qhov loj ntawm cov nickel tshem tawm yog qhov ywj pheej ntawm cov hluas.

Daim ntawv tshaj tawm dhau los, nqa tawm rau txoj hmoo ntawm cov neeg uas raug kev txom nyem los ntawm kev mob siab tshaj plaws ntawm cov neeg muaj mob tsis txaus ntseeg, qhia txog lub sijhawm ua haujlwm ntau tshaj plaws. Nyob rau lub sijhawm nruab nrab, piv txwv li, nyob rau hauv cov neeg mob uas muaj lub zog tsis zoo, kuv yuav tsum xav tau txoj kev me me nrog rau kev lim ntshav, dhau los 13 xyoo nrog mob hemodialysis thiab 19 xyoo nrog peritoneal lim ntshav.

Cov tshuaj pharmacokinetics ntawm cefepim hauv kev mob nkeeg nrog kev cuam tshuam ntawm lub siab tsis ua cim los ntawm mucoviscidosis. Corriguvanny dozi rau cov mob ailments tsis tsim nyog.

Thaum lub sijhawm thawj coj saib xyuas, qhov koob tshuaj ntawm cooj me 50 mg / kg ntawm daim tawv nqaij rau 12 xyoos tsis tau nce siab; tawv 8 xyoo.

Klіnіchnі cov yam ntxwv.

Kis tau tus mob, vim rhiab heev rau cov tshuaj mikroflora:

- tus vauv hu ua dichalny, suav nrog mob ntsws, mob ntsws,

- Shkіri thiab pidshkіrno klіtkovini,

- Іntraabdomіnalі інфекції, suav nrog tus kab mob peritonitis thiab інфекції жовчовивідних хлавів,

Kev kho mob Empiric эvorich iz iz neutropenichnoy garyachkoy.

Kev tiv thaiv kev ua haujlwm thaum muaj xwm txheej ceev nyob hauv lub tsev noj qab haus huv sab hauv.

- gнфекції secchivividnyh nraug vauv, ntxiv rau pyonephritis,

- cov ntaub ntawv shkіri thiab pidshkіrno klіtkovini,

- txoj kev kho kom ncaj ncees ориvorich iz ot neutropenichesky hotachka,

Kev sib txuam nrog cov tabs tseem ceeb tshaj plaws thiab pom kev sib hloov khoom.

Zastosovuchi siab ntawm aminoglycosides tam sim ntawd nrog Likesky trick Extentsef, fwm lub sijhawm ua haujlwm ntawm cov xaim nyiaj dhau los ntawm lub peev xwm ntawm nephrotoxicity thiab ototoxicity ntawm aminoglycoside tshuaj tua kab mob. Nephrotoxicity tau qhia rau tib lub sijhawm stasis ntawm cephalosporins nrog diuretics, xws li furosemide.

Extentsef concentration 1 txog 40 mg / ml nrog nrog cov txiaj ntsig zoo li niam txiv: 0.9% sodium chloride chloride rau 5%, 10% piam thaj piam thaj rau 6%, 6% sodium chloride rau 5%, 5% piam thaj thiab 0.9% sodium chloride rau inoculation, Ringer's test rau lactate thiab 5% piam thaj rau kev tiv thaiv kab mob.

Koj tsis tuaj yeem siv tshuaj sai nrog cov tshuaj uas tsim nyog, yuav cov tshuaj Extentsef (zoo li cov tshuaj tua kab mob b-lactam), tsis txhob siv tshuaj tam sim tshuaj metronidazole, vancomycin, sulfate, thiab gentamic acid. Thaum lub sij hawm tsim los ntawm cov tshuaj Extentsef nrog cov tshuaj kws kho mob, nkag mus rau hauv daim tawv nqaij tshuaj tua kab mob okremo.

Yuam kev ntawm kev sim ntshav hauv chaw kuaj.

Qhov xwm txheej ntawm cov zaub mov tiag tiag tuaj yeem ua rau hibnopositive cov tshuaj tiv thaiv rau cov piam thaj nyob hauv Benedict's reagent. Nws pom zoo kom ntsuam xyuas cov piam thaj, raws li cov tshuaj tiv thaiv enzymatic ntawm qabzib oxidation.

Nta zastosuvannya.

Rau cov neeg mob uas muaj kev pheej hmoo siab yuav kis tau mob hnyav (piv txwv li, rau cov neeg mob thiab menyuam yaus, lawv tau hloov lub cev hloov ntawm lub plab hlwb nrog kev ua haujlwm tsawg, thiab tsuas yog qee qhov kev kho mob hnyav tau qhia rau qhov no).

Nws yog qhov tsim nyog yuav tsum tau txheeb xyuas cov neeg uas tau tshwm sim thaum ntxov los ntawm qhov tsis txaus siab ntawm hom tsis muaj kev zais ntawm hypertrophy ntawm cefepime, cephalosporini, penicillin, thiab tshuaj tua kab mob. Tshuaj tua kab mob varto ua kev zoo siab nrog kev saib xyuas peb txhua tus qhuas iz txhua hom kev fab tshuaj, tshwj xeeb tshaj yog npaj tshuaj. Yog tias muaj kev fab tshuaj, cov tshuaj yuav tsum tau tsau. Cov kev tsis haum loj ntawm cov tsis muaj hom ntawm hyperpathy tuaj yeem ua rau adrenaline thiab qis dua kev kho mob.

Zastosovuvati nrog khaws cia ntawm cov neeg mob іz qaug dab peg ntawm cov nyom (zais hauv keeb kwm), tshwj xeeb suav.

Thaum raug mob stasis, kev siv tshuaj tua kab mob ntau yam ntawm tus kabmob pseudomembranous yog yuav luag sib txawv. Nws yog ib qho tseem ceeb uas yuav tsum tau ceev faj txog cov kab mob pathology thiab xav tau kev siv tshuaj yeeb tshuaj Extentsef Dosledzhennya rau txim rau cov neeg uas muaj tshuaj lom uas tuaj yeem tsim tawm Clostridium difficile, є Lub hauv paus tseem ceeb ntawm cov tshuaj tua kab mob hauv zej zog. Txhawm rau kuaj xyuas tus mob pseudomembranous mob plab, nws yog qhov tsim nyog yuav tau cog pob kws kho mob. Pseudomembranous colitis ntawm lub qhov ntxa theem ntawm qhov mob hnyav tuaj yeem mus rau lub teeb pom kev thaum kev npaj tsau. Hauv vipadok, cov neeg uas muaj kev sib haum xeeb thiab cov kauj ruam nyuaj yuav tsum tau saib zoo Clostridium difficile.

Rau cov neeg mob uas muaj lub cev tsis zoo ntawm lub luag haujlwm (tshem tawm creatinine ≤ 60 ml / hv), cov koob ntawm cov zaub mov noj yuav tsum tau kho los ntawm kev them nyiaj rau cov kev kub ceev ntawm cov tshuaj. Los ntawm cov hnub ntawd, thaum muaj suab nrov qis ntawm cov kab mob cefep hauv cov neeg mob uas tsis muaj tshuaj ntau, lawv kuj tuaj yeem nres qhov haujlwm ntawm nirk, thiab peb kuj tseem tuaj yeem ua kom muaj kev cuam tshuam rau lawv. Nrog lub koob tshuaj tiv thaiv kev nyab xeeb ib qib zuj zus, txo cov kauj ruam ntawm txoj haujlwm, qhov hnyav ntawm tus kab mob thiab cov kauj ruam rhiab ntawm microorganism mus rau tshuaj tua kab mob. Hauv cov txheej txheem ntawm kev saib tom qab muag, cov tshuaj tau tso tseg muaj qhov raug mob hnyav, lawv tau dhau los ua kev hem thawj rau lub neej, lossis ua rau lub cev tsis muaj zog: kev mob hlwb (qhov tsis zoo ntawm kev txiav txim, tsis nco qab, tsis nco qab) Feem ntau ntawm vipadas tau ruaj ntseg los ntawm cov neeg mob uas tsis zoo ntawm nirok, li dozosovuvili koob ntawm cefepim, tab sis nws raug pom zoo kom rov faib tawm. Inkoli cov kev tawm tsam hnyav tau raug txwv tsis pub dhau lub rooj noj mov, yakimiruyut ntau npaum, scorched los ntawm urahuvannyam funktsії nirok. Feem ntau, cov tsos mob ntawm tus mob nephrotoxicity tau cuam tshuam nrog werewolves, thiab tsis muaj cov cim ntawm cramping thiab / lossis tsis muaj mob ntawm hemodialysis.

Yuav tsum muaj kev txhim kho me ntsis yog tias tsis muaj pov thawj me ntsis ntawm kev sib hais sib tua yog tias muaj kev nce kab mob ntxiv rau yav tom ntej. Tsis pom kev tsis txaus sib xyaw cefepіmu (yak antibioticsshih tshuaj tua kab mob) tuaj yeem coj mus rau kev txhim kho superinfection. Nws yog ib qho tsim nyog yuav tsum tau ua kev rov ua ntu zus rau patsenta. Thaum lub sij hawm ntawm kev txhim kho ntawm superinfection, koj yuav tsum tau nyob nrog koj cov kev mus ntsib zaum kawg.

Bagato cephalosporins, suav nrog cefepim yog txuam nrog kev txo qis ntawm prothrombin.Ua ntej tsim pab pawg, koj yuav tsum nkag mus rau cov neeg mob nrog lub luag haujlwm ntawm lub qhov cub tawg, tab sis cov hais mav, menyuam yaus, cov menyuam yaus tab tom yws yws, thiab lawv tseem tau mus dhau qhov tsis tseem ceeb ntawm cov tshuaj tua kab mob. Nws yog qhov tsim nyog los tswj hwm prothrombin hauv cov neeg mob nrog pab pawg thiab yog tias xav tau kev kos npe ntawm K. K.

Nyob rau lub sijhawm muaj kev tsis sib haum xeeb, cefepim tuaj yeem yog qhov zoo tab sis tsis zoo los ntawm kev kuaj mob Coombs ncaj qha. Lub sijhawm hematologic lossis kev hloov ntshav, thaum cov ntshav tau qhia tias tau ua ib txoj hauv kev dhau los, yog tias kev sim tshuaj antiglobulin, tab sis kev kuaj Coombs tau siv rau cov neeg tshiab, niam tau tso tseg cov tshuaj tua kab mob ntawm cephalosporins tau, peb tuaj yeem tau txais qhov txiaj ntsig kev sim zoo.

Bulo tau raug coj los, yog li L-arginine tshuaj noj cov ntshav qabzib muaj cov metabolism hauv cov ntshav qab zib thiab cov calories tam sim ntawd hauv cov ntshav nrog teev tseg, ntau npaum li 33 npaug qhov ntau kawg tau pom zoo kom noj cov tshuaj cefepime. Qhov cuam tshuam ntawm qhov qis qis qis rau xyoo tshiab.

Thaum zasosuvannі lіdokainu yak rozniknika slіd vrakhovuvati іnformatsіy nrog bezpeki lіdokainu.

Zastosuvannya nyob rau lub sijhawm ntawm vaginosti abo xyoo ntawm lub mis

Kev tswj hwm tau zoo thiab kev tswj hwm tau zoo rau txoj hmoo ntawm ntu ntawm cov poj niam lub neej tsis tau nqa tawm, yog li Extent tuaj yeem muaj tokens ntawm lub hnub nyoog ib yam li leej niam, yog tias cov plaub hau tau sib rau leej niam los faib tawm lub zog ntawm tus me nyuam hauv plab.

Cefepim hauv da dej yog qhov me me, nkag mus ntawm lub mis yog nyob rau hauv cov mis, uas yog lub sijhawm ntawm cov neeg paub txog ntawm lub xyoo Extentsef ntawm lub mis.

Kev noj qab haus huv kom nqus cov nrawm ntawm cov tshuaj tiv thaiv thaum cheruvannі tsav tsheb thiab lwm yam txheej txheem.

Tsav rau cefepim kom tau txais qhov tshuaj tiv thaiv sai rau thaum lub tsheb thauj khoom cheruvanny, vim hais tias cov neeg hlau tsis yws nrog lub tswv yim tshiab, txawm li cas los xij, coj kuv tus nus hwm, tab sis tom qab ib teev kuv tuaj yeem siv tshuaj, Kuv tsis tuaj yeem cuam tshuam los ntawm cov leeg hlwb.

Sposib zososuvannya li dozi.

Zvichayna koob tshuaj rau lub sijhawm ntxov ua 1 g, muab cov haujlwm sab hauv lossis sab hauv nrog 12 xyoo. Zvichayna tsis tseem ceeb ntawm ib qho kev hais tawm - 7-10 hnub, cov kis hnyav tuaj yeem haus ntau yam tsis tseem ceeb.

Dosuvannya i shlyakh uvdennya var_yuyut fallowingly kindly rhiab rau microorganism, kev saib xyuas kev noj qab haus huv, theem ntawm qhov mob hnyav ntawm kev kis tus mob, nrog rau lub chaw pw ua haujlwm ntawm ailing nikor. Cov lus pom zoo ntawm qhov ntau kawg ntawm cov tshuaj Extentsef rau kev siv lub sijhawm tsis ua haujlwm ntawm lub rooj.

Нфекції сечових ххіів yooj yim thiab nruab nrab nrau

500 mg - 1 g sab hauv, tab sis sab hauv 'mob txhab

Ціїнші інфекції lub teeb thiab nruab nrab nrau

1 g sab hauv, tab sis sab hauv