Presartan N

Cov tshuaj nrog cov nyhuv antihypertensive, yog hais txog cov tshuaj, uas yog lub blocker tshwj xeeb. angiotensin receptors (hom AT1) Tsis inhibit enzyme (kinase II) uas rhuav tshem bradykininCov. Presartan txo qis ntshav siab aldosterone thiab norepinephrine, OPSS, HUAB TAIS, txo cov haujlwm tom qab, lub siab nyob hauv "lub me" lub voj voog ntawm cov ntshav ncig, muaj cov nyhuv diuretic. Nws inhibits kev txhim kho ntawm myocardial hypertrophy. Hauv cov neeg mob nrog CHF nce ntxiv kom lub cev ua si.

Tom qab txhaj ib zaug ntawm Presartan, cov nyhuv antihypertensive nce mus txog nws tus nqi siab tshaj plaws tom qab 6 teev, thiab maj mam txo qis dua hnub tom qab. Qhov siab tshaj plaws qhov ua rau pom yog pom nyob rau nruab nrab ib hlis tom qab pib ntawm kev kho mob nrog tshuaj.

Presartan, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Presartan yog coj tsis hais noj zaub mov, 1 zaug hauv ib hnub. Hauv kev kho mob leeg ntshav siab pom zoo koob tshuaj txhua hnub ntawm 50 mg, uas, yog tias tsim nyog, tuaj yeem nce ntxiv txog 100 mg. Thaum tus neeg mob yuav siv cov tshuaj diuretics siab ntau, qhov tshuaj yuav tsum tau txo kom 25 mg ib hnub twg.

Txog kev kho mob CHF cov koob tshuaj txhua hnub yog 12,5 mg, noj ib lub sijhawm, tom qab ntawd, nrog lub lis piam sib xyaw, qhov koob tshuaj tau nce 2 zaug (12.5, 25, 50 mg). Qhov kev saib xyuas txij nkawm yog 50 mg rau ib hnub. Txhawm rau txhim kho cov nyhuv hypotensive, nws yog qhov pom zoo kom kho Presartan N (Losartan nrog antihypertensive tus neeg sawv cev).

Kev sib txuam

Rov qab siv lub peev xwm nrog cov tshuaj muaj cov tshuaj poov tshuaj (poov tshuaj npaj, poov tshuaj-sparing diuretics) ntau qhov kev pheej hmoo ntawm kev nthuav dav hyperkalemiaCov. Kev sib xyaw ua ke ntawm kev noj tshuaj nrog tshuaj diuretics tuaj yeem ua rau poob qis HUAB TAISCov. Kev sib koom tes ntawm Presartan nrog NSAIDs pab txo cov nyhuv hypotensive ntawm cov tshuaj. Nrog rau kev tswj hwm tib lub sij hawm ntawm cov tshuaj nrog lwm cov tshuaj tiv thaiv kabmob, kev sib nrig sib hypotensive nyhuv.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv tshuaj ntawm Presartan yog cov koob tshuaj zaj duab xis: ntawm qhov koob tshuaj 25 thiab 50 mg - puag ncig biconvex, paj yeeb, 25 mg ntsiav tshuaj nrog cov kab sib faib rau ntawm ib sab, ntawm ntau npaum 100 mg - poob-zoo li, biconvex, dawb lossis yuav luag dawb nrog lub ntsej muag " 100 "ntawm ib sab thiab" BL "nyob rau lwm qhov (10 pcs. Hauv cov hlwv, 3 lub hlwv hauv lub thawv ntawv cardboard, 14 pcs. Hauv qhov khuav, 2 lub hlwv hauv ib lub thawv ntawv).

Kev Sau Ntawv 1 ntsiav tshuaj 25/50 mg:

• cov tshuaj nquag: losartan potassium - 25/50 mg,
• Cov khoom siv pabcuam: cov hmoov txhuv nplej siab, microcrystalline cellulose, talc huv, colloidal silicon dioxide, sodium starch glycolate, magnesium stearate, isopropyl cawv, methylene chloride, opadry OY-55030, zas xim liab.

Txheej Txheem 1 ntsiav tshuaj 100 mg:

• cov tshuaj nquag: losartan potassium - 100 mg,
• Cov khoom siv pabcuam: pob kws hmoov txhuv nplej siab, microcrystalline cellulose, talc, colloidal silicon dioxide, sodium carboxymethyl hmoov txhuv nplej siab, magnesium stearate, hypromellose, titanium dioxide, talc, macrogol.

Cov Tshuaj Pharmacokinetics

Presartan nrawm nrawm los ntawm lub plab zom mov (GIT). Metabolized los ntawm thawj zaug dhau los ntawm nplooj siab. Qib ntawm kev khi rau cov ntshav plasma protein ntawm losartan thiab nws cov metabolites yog 92–99%. Bioavailability - 33% (kev noj zaub mov tsis muaj kev cuam tshuam). Cov tshuaj yeeb yaj kiab tsis nkag rau cov ntshav-hlwb teeb meem. Nws tsis nthuav tawm hauv lub cev, kev nthuav tawm yog nqa nrog zis thiab tso cov kua tsib. Ib nrab-lub neej ntawm losartan yog 2 teev.

Kev ntsuas rau siv

• arterial tawg thiab sab laug ventricular hypertrophy (kom txo tau txoj kev pheej hmoo ntawm kev txhim kho hlab plawv pathologies thiab kev tuag),
• hom II mob ntshav qab zib mellitus nrog proteinuria (kom txo qis kev pheej hmoo ntawm proteinuria thiab hypercreatininemia),
• mob plawv nres yog siv ua ib feem ntawm kev sib xyaw ua ke thaum nws tseem tsis tuaj yeem siv cov tshuaj angiotensin hloov mus rau hauv enzyme (ACE) inhibitors.

Cov Yuav Tsum Muaj

• mob rau daim siab hnyav ˃ 9 cov ntsiab lus ntawm Child-Pugh nplai (rau 100 mg ntsiav tshuaj),
• cev xeeb tub thiab lactation,
• hnub nyoog txog 18 xyoo
• ntxiv qhov rhiab heev rau Presartan Cheebtsam.

Tus Txheeb Ze contraindications (rau 100 mg ntsiav tshuaj):

• mob gout
• hyperuricemia
• kev tsis haum tshuaj nyob rau yav dhau los kho nrog ACE inhibitors lossis lwm yam tshuaj,
• bronchial hawb pob,
• cov kab mob ntshav ntshav
• txo cov ntshav hauv lub cev ntim ntau ntau (BCC),
• arterial hypotension,
• kev tswj hwm nrog kev siv tshuaj uas tsis yog tshuaj steroidal anti-inflammatory (NSAIDs),
• mob plawv plawv
• hnub nyoog siab heev.

Cov lus qhia rau kev siv Presartan: hom thiab ntau npaum li cas

Presartan ntsiav tshuaj noj ntawm qhov ncauj 1 zaug hauv ib hnub, tsis hais txog ntawm cov khoom noj.

Qhia me me:

• arterial hypertension: qhov kev pom zoo thawj zaug yog 25 mg / hnub, qhov nruab nrab koob yog 50 mg / hnub, yog tias tsim nyog, nws tuaj yeem nce ntxiv txog 100 mg / hnub, thaum noj cov tshuaj 2 zaug hauv ib hnub yog pub,
• lub plawv tsis ua hauj lwm: qhov kev xav kom pib siv yog 12,5 mg / hnub, qhov koob tshuaj titration yog nqa nrog ib lim piam ib zaug. Qhov kev tswj hwm qhov nruab nrab yog 50 mg / hnub,
• kev tiv thaiv kev mob plawv thiab tuag ntawm cov neeg mob ntshav siab thiab mob ntshav tawm ntawm lub plawv tawg: qhov kev pom zoo thawj zaug yog 50 mg / hnub, ces nws nce rau 100 mg / hnub, lossis kev sib xyaw ua ke ntawm hydrochlorothiazide yog cov tshuaj,
• hom II mob ntshav qab zib mellitus nrog proteinuria: qhov pom zoo thawj zaug yog 50 mg / hnub, tom qab ntawd nws tau nce rau 100 mg / hnub.

Cov neeg mob tshwj xeeb:

• mob siab rau daim tawv nqaij (points 9 cov ntsiab lus ntawm Child-Pugh nplai), noj ntau npaum li cas ntawm diuretics, hemodialysis, hnub nyoog tshaj 75 xyoo: thawj qhov kev siv tshuaj yuav tsum tsis pub tshaj 25 mg / hnub,
• Lub siab ua kom lub siab ua haujlwm: qis dua ntawm cov tshuaj yuav tsum raug siv.

Sab sij huam

Presartan nyob rau hauv ntau npaum li cas ntawm 25 thiab 50 mg yog feem ntau zoo zam. Cov kev mob tshwm sim tuaj yeem tshwm sim hauv daim ntawv zawv plab, dyspepsia, leeg mob, o, mob taub hau, kiv taub hau, pw tsaug zog, hyperkalemia (poov tshuaj concentration> 5.5 meq / l), muaj qee zaus, hnoos, ua tsis taus pa, tachycardia, angioedema ( daim di ncauj, ntsej muag, pharynx thiab / lossis tus nplaig), urticaria, nce kev ua ntawm daim siab enzymes, ntshiab ntshav qib bilirubin.

Cov tshuaj phiv tuaj yeem tshwm sim thaum noj cov tshuaj Presartan hauv ib koob tshuaj ntawm 100 mg:

• hlab plawv mob: tachycardia, palpitations, txhaws ntswg, koob tshuaj txog orthostatic hypotension, arrhythmias, bradycardia, vasculitis, angina pectoris, myocardial infarction,
• lub plab zom mov: raws plab, mob plab, xeev siab, dyspepsia, qhuav ntawm lub qhov ncauj, mob tsis nco qab, ntuav, mob hniav, ua tsis taus pa, mob plab, mob plab, mob siab, mob siab, ua kom lub siab ua haujlwm tsis zoo,
• musculoskeletal system: spasms ntawm lub plab hlaub cov leeg, nraub qaum thiab mob ceg, mob caj dab, mob caj dab, mob lub xub pwg, hauv caug, mob fibromyalgia,
• tawv nqaij: erythema, tawv nqaij qhuav, ecchymosis, photosensitivity, alopecia, nce tawm hws,
• kev ua xua: ua pob khaus tawv, ua pob khaus, urticaria, mob caj pas (nrog rau txhaws ntawm lub ntsej muag lossis tus nplaig),
• hematopoiesis: thrombocytopenia, eosinophilia, purpure ntawm Schoenlein - Genoch, ntshav tsawg me ntsis hauv hemoglobin thiab hematocrit,
• cov leeg mob hauv lub cev: mob taub hau, kiv taub hau, pw tsaug zog, ntxhov siab, tsaug zog, pw tsaug zog, tsis nco qab zoo li qub, mob caj dab, mob ntshav qab zib, mob paj hlwb, mob ntshav siab, ataxia, kev nyuaj siab, tinnitus, tsaus muag, saj tsis zoo, mob taub hau, mob pob txha, mob qhov muag,
• cov kab mob ua pa: hnoos, mob pharyngitis, mob ntsws, txhaws ntswg, mob hlab qhov ntswg, mob hlab pas ib ce,
• cov kab mob genitourinary: tso zis mob plab, tso zis peremptory, lub raum tsis ua haujlwm, txo qis libido, impotence,
• lwm yam: asthenia, mob hauv siab, qaug zog, peripheral edema, exacerbation ntawm cov hoob kawm ntawm gout,
• kev kuaj ntshav kuaj ntshav: hyperuricemia, kev nce siab hauv kev tso zis ntawm urea, cov pa tshuaj nitrogen thiab creatinine nyob rau hauv cov ntshav ntshav, nce ntxiv hauv kev ua haujlwm ntawm hepatic transaminases (mob hnyav), hyperbilirubinemia.

Cov lus qhia tshwj xeeb

Yog lawm, thaum koj pib noj cov tshuaj Presartan, koj yuav tsum kho qhov lub cev qhuav dej, piv txwv li, los ntawm kev noj tshuaj diuretics nyob rau hauv cov koob tshuaj ntau, yog tias tsis muaj txoj hauv kev los kho BCC, kev kho yuav tsum pib nrog kev siv tshuaj tsawg.

Cov tshuaj uas cuam tshuam rau RAAS (renin-angiotensin-aldosterone system) muaj peev xwm ua kom muaj kev cia siab ntawm urea hauv cov ntshav thiab cov ntshav creatinine rau cov neeg mob uas muaj ob leeg lub raum artery stenosis lossis stenosis ntawm ib lub raum leeg.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Cov kev tshawb fawb tshwj xeeb ntawm kev cuam tshuam ntawm Presartan txog kev muaj peev xwm tsav tsheb thiab lwm yam txheej txheem nyuaj tseem tsis tau ua. Txawm li cas los xij, kev txiav txim siab yuav tsum tau muab rau kev txhim kho cov kev mob tshwm sim, xws li tsaug zog thiab kiv taub hau, xav tau kev ceev faj ntxiv thaum xyaum ua cov haujlwm uas yuav muaj kev phom sij.

Yeeb tshuaj sib cuam tshuam

• poov tshuaj-sparing diuretics, poov tshuaj npaj: txoj kev pheej hmoo ntawm kev tsim hyperkalemia,
• diuretics: qhov kev pheej hmoo ntawm hais lus txo qis hauv cov ntshav siab,
• beta-blockers thiab sympatholytics: txhim kho lawv cov nyhuv,
• rifampicin, flucanazole: txo qhov kev xav ntawm lub zog metabolite ntawm losartan hauv cov ntshav,
• lithium: kev nce ntxiv nyob rau hauv nws cov concentration hauv cov ntshav yog tau,
• NSAIDs: qhov cuam tshuam hypotensive ntawm cov tshuaj yog txo,
• lwm cov tshuaj tiv thaiv kev tiv thaiv: lawv cov nyhuv hypotensive kev sib raug zoo muaj zog.

Cov qauv ntawm Prezartan yog Brozaar, Blocktran, Vazotens, Zisakar, Kozaar, Lozap, Cardomin-Sanovel, Losartan, Renicard, Lakea, Vero-Lozartan, Lorista.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Presartan N ntsiav tshuaj yog noj ntawm qhov ncauj, tsis hais txog ntawm cov khoom noj.

Qhov tshuaj pib thiab txij nkawm yog 1 ntsiav tshuaj 12.5 mg + 50 mg 1 zaug ib hnub. Qhov siab tshaj plaws cov nyhuv antihypertensive tiav tom qab peb lub lis piam ntawm kev kho. Txhawm rau kom tau txais txiaj ntsig zoo tshaj qhov no, nws muaj peev xwm nce qhov ntau ntxiv ntawm cov tshuaj rau 2 ntsiav tshuaj ntawm qhov ntau npaum 12.5 mg + 50 mg ib hnub ib zaug. Qhov siab tshaj plaws niaj hnub noj yog 2 ntsiav tshuaj ntawm Presartan N.

Hauv cov neeg mob uas txo qis cov ntshav ncig (piv txwv li, thaum noj cov tshuaj diuretics), kev pom zoo pib ntawm losartan hauv cov neeg mob hypovolemia yog 25 mg ib hnub ib zaug. Hauv qhov no, kev kho mob nrog Presartan N yuav tsum tau pib tom qab kev tshem tawm ntawm diuretics thiab kho ntawm hypovolemia.

Rau cov neeg laus thiab cov neeg mob raum tsis ua hauj lwm zoo, suav nrog kev lim ntshav, tsis tas yuav tau txhaj koob tshuaj.

Txo txoj kev pheej hmoo ntawm cov hlab plawv txhaws qog thiab kev tuag ntawm cov neeg mob ntshav liab thiab sab laug ventricular hypertrophy

Tus txheej txheem koob tshuaj thawj zaug ntawm losartan yog 50 mg 1 zaug nyob rau ib hnub. Cov neeg mob uas tsis tuaj yeem ncav lub hom phiaj ntshav siab thaum noj losartan 50 mg / hnub xav tau kev kho mob nrog kev sib xyaw nrog losartan nrog cov tshuaj tsawg kawg ntawm hydrochlorothiazide (12.5 mg), thiab yog tias tsim nyog, nce qhov koob tshuaj losartan txog 100 mg hauv kev sib xyaw nrog hydrochlorothiazide ntawm ib koob tshuaj 12,5 mg / hnub, yav tom ntej - nce ntxiv rau 2 ntsiav tshuaj ntawm cov tshuaj ntawm qhov ntau npaum ntawm 50 / 12.5 mg nyob rau hauv tag nrho (100 mg losartan thiab 25 mg ntawm hydrochlorothiazide ib hnub ib zaug).

Pharmacological kev txiav txim

Presartan H muaj kev sib xyaw ntawm losartan thiab hydrochlorothiazide, ob qho sib xyaw ua ke muaj cov nyhuv tiv thaiv kabmob, txo cov ntshav siab (BP) rau ntau dua li txhua ntu sib cais.

Losartan yog qhov kev paub tseeb angiotensin II receptor antagonist (subtype AT1) rau kev tswj hwm qhov ncauj. Losartan thiab nws cov tshuaj pharmacologically nquag metabolite (E 3174) ob qho tib si hauv vitro thiab hauv vivo thaiv tag nrho cov kev mob ntawm lub cev ntawm angiotensin II, tsis hais txog qhov chaw lossis txoj kev ntawm synthesis. Losartan xaiv zoo khi rau AT1 receptors thiab tsis khi los yog thaiv cov receptors ntawm lwm cov tshuaj hormones thiab ion channel, uas ua lub luag haujlwm tseem ceeb hauv kev xav txog kev ua haujlwm ntawm lub hlab plawv. Tsis tas li, losartan tsis inhibit angiotensin-hloov enzyme (ACE) - kininase II, thiab, raws li, tsis tiv thaiv kev puas tsuaj ntawm bradykinin, yog li ntawd cov kev phiv los cuam tshuam rau ntawm bradykinin (piv txwv li, angioedema) muaj tsawg heev.

Thaum siv losartan, qhov uas tsis muaj ntawm cov neeg tsis zoo ntawm lub tswv yim tsis zoo rau renin secretion ua rau muaj kev nce plasma renin ntau ntxiv. Kev nce ntawm renin kev ua si ua rau kev nce ntxiv ntawm angiotensin II hauv ntshav ntshav. Txawm li cas los xij, kev ua haujlwm ntawm antihypertensive thiab txo qis ntawm kev saib xyuas ntawm aldosterone hauv cov ntshav ntshav txuas ntxiv, uas qhia tau tias muaj kev cuam tshuam zoo ntawm cov tshuaj angiotensin II. Losartan thiab nws cov metabolite nquag muaj kev paub zoo dua rau angiotensin I receptors dua rau angiotensin P. receptors Cov metabolite nquag yog 10-40 zaug ntau dua li losartan.

Tom qab ib qho kev tswj hwm ntawm qhov ncauj, cov txiaj ntsig antihypertensive (txo qis hauv systolic thiab diastolic ntshav siab) nce mus txog qhov siab tshaj plaws tom qab 6 teev, tom qab ntawd maj mam txo qis hauv 24 teev. Qhov siab tshaj plaws antihypertensive nyhuv loj hlob tuaj 3-6 lub lis piam tom qab pib siv tshuaj.

Hydrochlorothiazide - thiazide diuretic, cuam tshuam rau kev rov qab ua kom rov qab cov sodium, chlorine, potassium, magnesium ions nyob rau hauv nealron distal, qeeb qhov kev nthuav tawm ntawm calcium, uric acid. Ib qho kev nce ntxiv ntawm lub raum tsis ua haujlwm ntawm cov ions no yog nrog los ntawm cov zis ntau ntxiv (vim yog osmotic khi ntawm cov dej). Txo cov ntshav plasma ntim ntau dua, nce ntshav plasma renin kev ua si thiab aldosterone secretion. Thaum noj hauv cov koob tshuaj loj, hydrochlorothiazide ua rau kom muaj qhov zam ntxiv ntawm bicarbonates, thaum siv mus sij hawm ntev yuav txo kev nthuav dav ntawm calcium.

Cov txiaj ntsig antihypertensive nthuav dav vim qhov txo qis hauv lub ntim ntawm cov ntshav ncig (BCC), kev hloov pauv ntawm cov teeb meem cuam tshuam ntawm phab ntsa vascular, txo qis ntawm cov xov xwm cuam tshuam ntawm vasoconstrictor amines (adrenaline, norepinephrine) thiab kev nce siab ntawm cov kev cuam tshuam ntawm ganglia. Nws tsis cuam tshuam dab tsi txog ntshav siab. Cov nyhuv diuretic yog pom tom qab 1-2 teev, nce mus txog qhov siab kawg tom qab 4 teev thiab kav ntev li 6-12 teev. Cov nyhuv antihypertensive tshwm sim hauv 3-4 hnub, tab sis 3-4 lub lis piam xav tau kom ua tiav txoj kev kho kom zoo dua.

Cov lus nug, lus teb, tshuaj xyuas ntawm cov tshuaj Presartan N

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Tso daim ntawv, ntim thiab muaj pes tsawg leeg Presartan N

Cov ntsiav tshuaj, zaj duab xis-coated daj, yog oval biconvex, hauv ntu ntu: qhov tseem ceeb yog los ntawm xim dawb mus rau yuav luag dawb.

Tshwjxeeb: lactose monohydrate 111.50 mg, microcrystalline cellulose 58 mg, pregelatinized hmoov txhuv 3 mg, pob kws hmoov txhuv nplej 12 mg, colloidal silicon dioxide 1 mg, magnesium stearate 2 mg.

Muaj pes tsawg leeg plhaub:
hypromellose 2.441 g, titanium dioxide 0.60 mg, talc 1.50 mg, macrogol-6000 0.40 mg, qog quinoline daj 0.058 mg.

14 pcs. - blister packs (2) - pob ntawv ntawm cardboard.

Tsuas tshuaj thiab tswj hwm

Nrog rau kev hloov cov ntshav tawm, qhov kev muab tshuaj txhua hnub yog 25 mg, qhov nruab nrab txhua hnub koob yog 50 mg, qhov ntau zaus ntawm kev tswj hwm yog 1 zaug / hnub.

Qhov siab tshaj plaws kev kho mob tshwm sim 3-6 lub lis piam tom qab pib siv tshuaj. Yog tias tsim nyog, cov koob tshuaj yuav raug nce ntxiv rau 1 00 mg ib hnub twg. Hauv qhov no, nws yog qhov ua tau rau noj cov tshuaj 2 zaug hauv ib hnub.

Thawj koob tshuaj rau cov neeg mob lub siab yog 12,5 mg 1 zaug / hnub. Feem ntau, cov koob tshuaj tau suav sau nyob rau ntawm txhua lub limtiam (piv txwv li 12,5 mg / hnub, 25 mg / hnub. 50 mg / hnub) rau qhov nruab nrab tswj kev noj tshuaj ntawm 50 mg 1 zaug / hnub, nyob ntawm tus neeg mob lub siab ntev rau cov tshuaj.

Thaum muab cov tshuaj rau cov neeg mob uas tau txais kev tso tshuaj ntau dhau ntawm lub koob tshuaj, yuav tsum txo qhov 25 mg 1 zaug / hnub.

Cov neeg mob uas lub siab tsis ua haujlwm lub zog yuav tsum tau txhaj cov tshuaj losartan qis dua,

Hauv cov neeg mob laus, nrog rau cov neeg mob uas lub raum tsis zoo, suav nrog cov neeg mob ntawm hemodialysis, tsis tas yuav kho qhov pib ntawm cov tshuaj.

Presartan tuaj yeem kho nyob rau hauv nrog lwm cov tshuaj tiv thaiv antihypertensive. Losartan tuaj yeem siv tau tsis hais noj zaub mov.

Sab sij huam

Presartan feem ntau zoo tiv thaiv. Nws tuaj yeem tshawb pom: raws plab, dyspepsia, mob nqaij, o, kiv taub hau, ntxhov siab txog pw tsaug zog, mob taub hau, hyperkalemia (poov tshuaj hauv ntshav ntau tshaj 5.5 meq / l). Muaj qee zaus, yuav muaj qhov hnoos, ua pa tsis ua haujlwm, tachycardia, mob hlwb (suav nrog o ntawm lub ntsej muag, daim di ncauj, pharynx thiab / lossis tus nplaig), urticaria, kev ua haujlwm ntau ntawm "mob siab" transaminases, bilirubin hauv cov ntshav.

Daim ntawv thov nta

Hauv cov neeg mob lub cev qhuav dej (piv txwv li, tau txais kev kho mob nrog kev tso tshuaj ntau dhau), cov tsos mob tshwm sim thaum pib kho nrog Presartan. Nws yog qhov tsim nyog los kho lub cev qhuav dej ua ntej pib kho mob los yog pib kho nrog kev noj tshuaj tsawg.

Cov ntaub ntawv pharmacological qhia tau hais tias qhov kev xav ntawm losartan hauv plasma ntawm cov neeg mob ntshav siab yog nce ntxiv, yog li, cov neeg mob uas muaj keeb kwm muaj kab mob siab yuav tsum tau sau cov tshuaj qis.

Qee cov tshuaj uas cuam tshuam rau hauv kev kaw lus kipinapgiotensin tuaj yeem ua kom ntshav urea thiab ntshav creatinine ntau rau cov neeg mob uas tsis ua haujlwm zoo.

Kuj tsis paub meej tias losartan puas txawj mob niam mis. Thaum cov tshuaj presartan yog tus txiav txim thaum lactation, yuav tsum txiav txim siab txiav txim siab tsis pub niam mis, lossis tsum kom tsis txhob siv tshuaj kho mob.