Glimecomb - cov lus qhia rau kev siv, tshuaj xyuas, tshuaj tiv thaiv kab mob thiab cov ntawv tso tawm (ntsiav tshuaj 40 mg 500 mg) ntawm cov tshuaj rau kev kho mob ntawm tsis muaj tshuaj insulin-yam muaj ntshav qab zib 2 rau cov neeg laus, menyuam yaus thiab cev xeeb tub

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb GlimecombCov. Muab tswv yim los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Glimecomb hauv lawv qhov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Glimecomb analogues nyob rau hauv muaj cov qauv txheej txheem. Siv rau kev kho mob ntawm qhov tsis-insulin-hom mob ntshav qab zib 2 hauv cov neeg laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab lactation. Cov lus sib xyaw thiab kev cuam tshuam ntawm cov tshuaj nrog cawv.

Glimecomb - xyaw tshuaj hypoglycemic rau kev siv lub qhov ncauj. Glimecomb yog kev sib koom ua ke ntawm ob qhov ncauj hypoglycemic tus neeg sawv cev ntawm cov pab pawg biguanide thiab sulfonylurea pawg ntawm derivatives. Nws muaj pancreatic thiab extrapancreatic kev txiav txim.

Glyclazide (thawj qhov tshuaj yeeb tshuaj Glimecomb) yog sulfonylurea derivative. Tsim kho thaj ua rau cov insulin los ntawm cov txiav, nce ntxiv ntawm qhov tsis haum ntawm cov ntaub so ntswg mus rau insulin. Tsim kho kev ua ub no ntawm intracellular enzymes, suav nrog cov leeg glycogen synthetase. Nws rov kho lub sijhawm thaum ntxov ntawm insulin secretion, txo lub sijhawm ncua sijhawm ntawm lub sijhawm noj mus rau insulin secretion pib, thiab txo qis tom qab (tom qab noj mov) hyperglycemia. Ntxiv nrog rau cuam tshuam rau cov metabolism hauv kev ua haujlwm, nws cuam tshuam microcirculation, txo platelet adhesion thiab kev sib sau ua ke, qeeb kev txhim kho ntawm parietal thrombosis, normalizes vascular permeability thiab inhibits kev txhim kho ntawm microthrombosis thiab atherosclerosis, rov qab cov txheej txheem ntawm physiological parietal fibrinolysis, thiab tawm tsam cov tshuaj tiv thaiv muaj zog rau vascular adrenal. Txo cov kev loj hlob ntawm cov ntshav qab zib retinopathy nyob rau theem tsis-loj hlob, nrog cov ntshav qab zib nephropathy nrog kev siv lub sijhawm ntev, qhov tseem ceeb txo qis rau cov proteinuria tau sau tseg. Nws tsis ua rau muaj qhov nce hauv lub cev qhov hnyav, vim nws muaj lub luag haujlwm tseem ceeb ntawm cov tshuaj tiv thaiv thaum ntxov thiab tsis ua rau hyperinsulinemia, nws pab txo lub cev qhov hnyav hauv cov neeg mob rog, ua raws li kev noj zaub mov zoo.

Metformin (qhov tshuaj thib ob tseem ceeb ntawm cov tshuaj Glimecomb) belongs rau cov pab pawg ntawm biguanides. Nws txo cov concentration ntawm cov piam thaj hauv cov ntshav los ntawm inhibiting gluconeogenesis nyob rau hauv daim siab, txo qis kev nqus ntawm cov piam thaj los ntawm lub plab zom mov (GIT) thiab nce nws siv hauv cov ntaub so ntswg. Nws txo qhov kev xav hauv cov ntshav cov ntshav ntawm triglycerides, cov roj cholesterol thiab ntshav qab zib lipoproteins tsawg (LDL), txiav txim siab ntawm lub plab khoob, thiab tsis hloov pauv qhov lipoproteins ntawm qhov sib txawv. Pab ua kom ruaj khov lossis txo lub cev qhov hnyav. Thaum tsis muaj cov tshuaj insulin nyob rau hauv cov ntshav, kev kho mob tsis pom tseeb. Kev ua kom lub cev ntshav qis tsis tuaj yeem ua. Txhim kho cov khoom fibrinolytic ntawm cov ntshav vim yog kev tsuj ntawm ib qho inhibitor ntawm tus activator profibrinolysin (plasminogen) cov ntaub so ntswg hom.

Muaj pes tsawg leeg

Glyclazide + Metformin + kev xa tawm.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus ntawm gliclazide yog qhov siab. Plasma protein khi yog 85-97%. Cov tshuaj txiav tawm hauv daim siab. Nws yog tawm hauv feem ntau hauv daim ntawv ntawm metabolites los ntawm ob lub raum - 70%, los ntawm txoj hnyuv - 12%.

Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus ntawm metformin yog 48-52%. Sai sai nqus los ntawm cov hnyuv. Kev tsis txaus siab txog kev noj qab haus huv (ntawm lub plab khoob) yog 50-60%. Plasma protein khi yog negligible. Metformin muaj peev xwm khaws ntau ntxiv hauv cov ntshav liab. Nws yog tawm los ntawm lub raum, feem ntau yog hauv daim ntawv tsis hloov pauv (glomerular pom thiab tubular tso zis) thiab los ntawm txoj hnyuv (txog 30%).

Cov Khoom Qhia

hom 2 mob ntshav qab zib mellitus (non-insulin dependant) nrog qhov tsis muaj txiaj ntsig ntawm kev kho kev noj haus, kev tawm dag zog thiab kev kho mob yav dhau los nrog metformin lossis gliclazide,
hloov cov kev kho mob yav dhau los nrog ob yam tshuaj (metformin thiab gliclazide) hauv cov neeg mob uas muaj ntshav qab zib hom 2 (tsis-insulin-tiv thaiv) nrog cov ntshav khov thiab tswj tau ntshav qabzib.

Tso Tawm Cov Ntawv

Ntsiav tshuaj 40 mg + 500 mg.

Cov lus qhia rau kev siv thiab ntau npaum li cas

Glimecomb noj ntawm qhov ncauj thaum lossis noj mov tom qab noj mov tas. Qhov ntau thiab tsawg ntawm cov tshuaj tau txiav txim los ntawm tus kws kho mob tshwj xeeb rau txhua tus neeg mob, nyob ntawm seb cov ntshav nyob ntawm seb ntau npaum li cas.

Thawj koob tshuaj feem ntau yog 1-3 ntsiav tshuaj hauv ib hnub nrog maj mam xaiv cov koob tshuaj kom txog thaum them nyiaj ruaj khov ntawm tus kabmob. Qhov siab tshaj plaws niaj hnub noj yog 5 ntsiav tshuaj.

Feem ntau siv tshuaj ntawd noj 2 zaug hauv ib hnub (sawv ntxov thiab yav tsaus ntuj).

Sab sij huam

hypoglycemia (ua txhaum rau kev noj tshuaj ntau thiab noj zaub mov tsis zoo) - mob taub hau, nkees, tshaib plab, tawm hws ntau, ua rau lub cev tsis muaj zog, ua rau lub cev tsis muaj zog, kiv taub hau, ua kom tsis muaj kev sib haum xeeb ntawm kev txav mus los, ib ntus ntawm cov leeg hlwb tsis zoo,
nrog kev vam meej ntawm hypoglycemia, poob ntawm kev tswj yus tus kheej, tsis nco qab,
lactic acidosis - ua kom tsis muaj zog, myalgia, ua pa nyuaj, qaug zog, mob plab, hypothermia, txo ntshav siab (BP), bradyarrhythmia,
dyspepsia - xeev siab, zawv plab, qhov kev xav ntawm qhov hnyav hauv lub epigastrium, qhov "xim hlau" saj hauv lub qhov ncauj, tsis qab los noj mov,
mob rau daim siab, mob cholestatic jaundice (yuav tsum tau tawm yeeb tshuaj),
nce kev ua haujlwm ntawm hepatic transaminases, alkaline phosphatase (ALP),
inhibition ntawm cov pob txha mob hematopoiesis - mob ntshav liab, thrombocytopenia, leukopenia,
pruritus, urticaria, maculopapular pob,
pom kev pom
hemolytic anemia,
kev tsis haum vasculitis,
lub neej ua rau lub siab tsis ua hauj lwm.

Cov Yuav Tsum Muaj

yam 1 mob ntshav qab zib mellitus (insulin-dependant),
mob ketoacidosis,
kuaj cov ntshav qab zib, mob ntshav qab zib tsis xeev,
ntshav qab zib,
mob raum tsis zoo,
mob uas tuaj yeem ua rau lub raum hloov pauv: lub cev qhuav dej, ua mob hnyav, ceeb,
mob los yog mob mus ntev nrog cov nqaij mos hypoxia: lub plawv tsis ua haujlwm, ua pa tsis ua haujlwm, tsis ntev los no myocardial infarction, poob siab,
daim siab ua hauj lwm
porphyria
cev xeeb tub
lactation (noj niam mis),
siv cov miconazole kom nruj,
cov kev mob uas yuav tsum muaj kev kho tshuaj insulin, suav nrog cov kis kab mob, kev phais mob loj, kev raug mob, kev kub nyhiab,
haus cawv ntev,
qaug cawv ua rau qaug cawv,
lactic acidosis (nrog rau keeb kwm ntawm)
siv tsawg kawg 48 teev ua ntej thiab nyob rau hauv 48 teev tom qab ua kev tshawb fawb radioisotope lossis xoo hluav taws xob nrog kev qhia ntawm iodine-muaj qhov sib piv nruab nrab,
ua raws li kev noj haus kom tsis txhob muaj calories ntau tsawg (tsawg dua 1000 calories tauj ib hnub),
muaj lub cev tsis haum rau lub tshuaj,
ua kom poob rau lwm qhov sulfonylurea derivatives.

Cev xeeb tub thiab lactation

Kev siv ntawm cov tshuaj Glimecomb thaum cev xeeb tub yog contraindicated. Thaum npaj kev cev xeeb tub, nrog rau kev xeeb tub thaum lub sijhawm noj cov tshuaj Glimecomb, nws yuav tsum tshem tawm thiab cov tshuaj insulin yuav tsum raug kho.

Glimecomb yog qhov sib kis hauv kev pub niam mis, txij li cov tshuaj yeeb dej caw tuaj yeem tawm hauv niam mis. Hauv qhov no, koj yuav tsum hloov mus rau kev siv tshuaj insulin lossis txwv kev pub niam mis.

Siv rau menyuam yaus

Siv rau cov neeg mob laus

Nws tsis pom zoo kom siv cov tshuaj Glimecomb hauv cov neeg mob hnub nyoog laus dua 60 xyoo uas ua haujlwm lub cev hnyav, uas cuam tshuam nrog kev pheej hmoo ntawm cov kab mob lactic acidosis.

Cov lus qhia tshwj xeeb

Glimecomb kev kho mob yog nqa tawm tsuas yog ua ke nrog cov khoom noj uas tsis muaj calorie tsawg, carb tsawg. Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam qib ntshav qabzib hauv cov ntshav ntawm lub plab khoob thiab tom qab noj mov, tshwj xeeb tshaj yog nyob rau thawj hnub ntawm kev kho mob nrog tshuaj.

Glimecomb tuaj yeem tsuas yog kho rau cov neeg mob tau txais kev noj mov tsis tu ncua, uas tsim nyog noj tshais thiab muab cov khoom noj txaus rau hauv kev noj haus.

Thaum sau tshuaj, nws yuav tsum tau yug los rau hauv lub siab hais tias vim kev noj cov tshuaj sulfonylurea derivatives, hypoglycemia tuaj yeem txhim kho, thiab hauv qee kis muaj mob hnyav thiab ntev, yuav tsum tau pw hauv tsev kho mob thiab ntshav qabzib rau ob peb hnub. Kev mob ntshav qab zib feem ntau pib txhim kho nrog cov zaub mov tsis muaj calorie, tom qab ua haujlwm ntev lossis ua kom ib ce muaj zog, tom qab haus dej haus cawv, lossis thaum noj ntau yam tshuaj hypoglycemic nyob rau tib lub sijhawm. Txhawm rau kom zam dhau kev txhim kho hypoglycemia, yuav tsum ceev faj thiab xaiv ib koob tshuaj yuav tsum tau, nrog rau kev muab tus neeg mob nrog cov ntaub ntawv tiav ntawm cov kev kho mob uas tau thov. Nrog rau kev tawm dag zog ntawm lub cev thiab lub siab, thaum hloov cov khoom noj, kev kho qhov ntau ntawm cov tshuaj Glimecomb yog qhov tsim nyog.

Tshwj xeeb tshaj yog rhiab rau qhov kev txiav txim ntawm cov tshuaj hypoglycemic yog cov neeg laus, cov neeg mob uas tsis tau txais kev noj haus zoo, nrog rau lub xeev tsis muaj zog txaus, cov neeg mob kev txom nyem los ntawm pituitary-adrenal tsis txaus.

Beta-blockers, clonidine, reserpine, guanethidine tuaj yeem npog qhov chaw kho mob tshwm sim ntawm hypoglycemia.

Cov neeg mob yuav tsum tau ceeb toom txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib siab ntau thaum muaj kev noj tshuaj cawv (haus cawv), tsis muaj tshuaj tiv thaiv tsis haum tshuaj (NSAIDs), thiab tshaib plab.

Nrog kev phais mob ntau thiab kev raug mob, kub hnyiab ntev, kis kab mob nrog febrile syndrome, nws yuav tsum tso tshuaj kom qhov ncauj tsis zoo thiab kho tshuaj insulin.

Hauv kev kho, lub raum ua haujlwm saib xyuas yog qhov tsim nyog. Kev txiav txim siab ntawm lactate hauv cov ntshav yuav tsum tau nqa tawm tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia. Nrog kev txhim kho ntawm cov kab mob lactic acidosis, kev txiav tawm ntawm kev kho mob yog yuav tsum tau ua.

48 teev ua ntej kev phais mob lossis kev tso dej ntawm lub cev iodine uas muaj cov kab mob radiopaque, noj Glimecomb yuav tsum tsis ua mus ntxiv. Txoj kev kho yog pom zoo kom rov hais dua tom qab 48 teev.

Tawm tsam keeb kwm ntawm kev kho nrog Glimecomb, tus neeg mob yuav tsum tso tseg kev haus cawv thiab / lossis cov tshuaj cawv thiab muaj tshuaj thiab zaub mov.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Thaum kho nrog Glimecomb, kev saib xyuas yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm cov kev phom sij uas yuav tsum muaj kev cuam tshuam ntau ntxiv thiab ceev ntawm cov kev tiv thaiv psychomotor.

Yeeb tshuaj sib cuam tshuam

Ntxiv dag zog rau qhov kev tiv thaiv hypoglycemic ntawm cov tshuaj Glimecomb tau pom nrog tib lub sijhawm siv nrog angiotensin-hloov pauv enzyme (ACE) inhibitors (captopril, enalapril), histamine H2-receptor blockers (cimetidine), tshuaj tiv thaiv antifungal (miconazole, fluconazole), NSAIDs, phenobonbenen, (clofibrate, bezafibrat), tshuaj tiv thaiv mob TB (ethionamide), salicylates, coumarin anticoagulants, anabolic steroids, beta-blockers, monoa inhibitors inoxidase (MAO), sulfonamides ntev ntev, nrog cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, lwm pyrimidide tshuaj insulin), allopurinol, oxytetracycline.

Kev txo qis hauv cov nyhuv hypoglycemic ntawm cov tshuaj Glimecomb tau pom nrog tib lub sijhawm nrog barbiturates, glucocorticosteroids (GCS), adrenergic agonists (epinephrine, clonidine), tshuaj antiepileptic (phenytoin), qeeb calcium calcium blockers, carbonic anhydrase inhibitors, thiazide amide amide diam. asparaginase, nrog baclofen, danazole, diazoxide, isoniazid, nrog morphine, rhytodrine, salbutamol, terbutaline, nrog glucagon, rifampicin, nrog g rmonami qog, lithium ntsev, muaj koob nicotinic acid, chlorpromazine, qhov ncauj contraceptives thiab estrogens.

Ua rau muaj kev pheej hmoo ntawm ventricular extrasystole nyob rau tom qab ntawm cov mob glycosides.

Cov tshuaj noj uas ua kom cov leeg hlwb hematopoiesis ua rau muaj kev pheej hmoo ntawm myelosuppression.

Ethanol (cawv) ua rau muaj feem ntau ntawm cov kab mob lactic acidosis.

Metformin txo cov kev xav ntau hauv plasma thiab ib nrab ntawm lub neej ntawm furosemide los ntawm 31 thiab 42.3%, ntsig txog.

Furosemide ua rau kom qhov siab tshaj plaws ntawm metformin los ntawm 22%.

Nifedipine nce ntxiv kev nqus, ua rau qis qis ntawm kev pom ntawm metformin.

Cov tshuaj Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren thiab vancomycin) zais cia hauv cov tubules sib tw rau cov tub ntxhais thauj khoom thiab, nrog kev kho mob ntev, tuaj yeem nce qhov siab tshaj plaws ntawm metformin hauv ntshav ntshav los ntawm 60%.

Cov tshuaj ntawm cov tshuaj Glimecomb

Glimecomb tsis muaj cov qauv txheej txheem rau cov tshuaj nquag.

Cov tshuaj piv rau qhov ua kom ua tau zoo (tshuaj rau kev kho mob ntawm qhov tsis muaj ntshav qab zib-tsis muaj ntshav qab zib mellitus):

Avandamet
Av ‡ Q
Adebite
Amaril
Tus tub sab
Antidiab
Arfazetin,
Bagomet,
Betanase
Biosulin P,
Vazoton
Lub Neej
Vipidia,
Galvus
Glemaz
Glibamide
Glibenez
Glibomet,
Glidiab
Glucophage,
Ntujnrim,
Daonil
Lawj xeeb
Diastabol,
Dibikor
Tshuaj insulin
Teev npe
Metfogamma,
Metformin
Mikstard Penfill,
Monotard MC,
Neovitel
NovoMix Penfill,
Noliprel A
Orsoten
Pankragen,
Pensulin,
Pioglar
Predian
Tubkawm Presartan
Khaws
Saxenda
Silubin Rov Tawm,
Siofor
Starlix
Telzap
Telsartan
Tricor
Txog rau cov,
Chitosan
Chlorpropamide
Neej Neeg,
Neeg lim hiam
Cigapan
Endur-B,
Erbisol
Euglucon,
Januvius
Yanumet Ntev.

Endocrinologist cov tswv yim

Cov tshuaj tiv thaiv kev phom sij Glimecomb muaj cov npe nqaim ntawm cov cim ntsuas thiab qhov muaj ntau yam sib luag ntawm cov lus qhia sib kis. Yog li, nws tsis tas yuav muab nws tas li. Cov koob tshuaj rau txhua tus neeg mob uas muaj mob ntshav qab zib hom 2 Kuv xaiv ntawm tus kheej. Hauv cov neeg mob uas ua raws li txoj cai ntawm kev noj tshuaj Glimecomb, qhov tshwm sim tsis zoo tshwm sim ntau dua li cov neeg mob uas tsis ua raws li cov lus pom zoo. Txawm hais tias qee ntu kev mob ntshav siab ntau nrog qhov tsis nco qab muaj qhov tshwm sim hauv kuv qhov kev coj ua thaum cov neeg mob yuav tsum tau mus pw hauv tsev kho mob. Tab sis feem ntau, kuv tuaj yeem hais tias qhov tshuaj tau pom zoo zoo los ntawm tus neeg mob.

Kev ntsuas rau siv

- hom 2 mob ntshav qab zib mellitus (non-insulin dependant) nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj, kev tawm dag zog thiab kev kho mob yav dhau los nrog metformin lossis gliclazide,

- hloov kev kho mob yav dhau los nrog rau ob yam tshuaj (metformin thiab gliclazide) hauv cov neeg mob uas muaj ntshav qab zib hom 2 (tsis-insulin-tiv thaiv) nrog cov ntshav khov thiab tswj tau ntshav qabzib.

Cov Yuav Tsum Muaj

- yam 1 mob ntshav qab zib mellitus (insulin-dependant),

- Lub raum khiav tsis zoo,

- mob nyhav uas tuaj yeem ua rau lub raum pauv hloov: lub cev qhuav dej, ua mob hnyav, ceeb,

- mob ceev lossis mob ntev nrog cov nqaij mos hypoxia: lub plawv tsis ua haujlwm, ua pa tsis ua haujlwm, tsis ntev los no myocardial infarction, poob siab,

- lactation (pub niam mis),

- tej yam mob uas yuav tsum tau kho cov tshuaj insulin, suav nrog kis kab mob sib kis, kev phais mob hnyav, kev raug mob, kev kub nyhiab,

- qaug cawv ua rau qaug cawv,

- lactic acidosis (suav nrog keeb kwm),

- siv tsawg kawg 48 teev ua ntej thiab nyob rau hauv 48 teev tom qab ua kev tshawb fawb radioisotope lossis X-ray nrog kev qhia ntawm iodine-contrast contrast medium,

- kev ua raws nraim rau kev noj zaub mov kom tsis txhob muaj calories ntau tsawg (tsawg dua 1000 cal / hnub),

- Cov tshuaj tiv thaiv tsis haum rau cov tshuaj,

- Cov tshuaj tiv thaiv tsis haum rau lwm cov sulfonylurea derivatives.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Cov tshuaj yog noj qhov ncauj thaum lub sijhawm lossis tom qab noj mov tas. Qhov ntau thiab tsawg ntawm cov tshuaj tau txiav txim los ntawm tus kws kho mob tshwj xeeb rau txhua tus neeg mob, nyob ntawm seb cov ntshav nyob ntawm seb ntau npaum li cas.

Thawj koob tshuaj feem ntau yog 1-3 ntsiav tshuaj / hnub nrog maj mam xaiv cov koob tshuaj kom txog thaum them nyiaj ruaj khov ntawm tus kabmob. Qhov siab tshaj plaws niaj hnub noj yog 5 ntsiav tshuaj.

Feem ntau cov tshuaj no yuav noj 2 zaug / hnub (sawv ntxov thiab yav tsaus ntuj).

Sab sij huam

Los ntawm cov kab mob endocrine: hypoglycemia (kev ua txhaum ntawm txoj kev noj tshuaj ntau thiab noj zaub mov tsis txaus) - mob taub hau, nkees, tshaib plab, tawm hws, mob tsis muaj zog, mob plab, kiv taub hau, ua tsis tau haujlwm ntawm kev txav mus los, ib ntus ntawm lub cev tsis zoo, nrog kev txhim kho ntawm hypoglycemia, poob ntawm kev tswj tus kheej yog ua tau, tsis nco qab.

Los ntawm ib sab ntawm cov metabolism: hauv qee kis - lactic acidosis (tsis muaj zog, myalgia, ua pa tsis haum, tsaug zog, mob plab, hypothermia, txo ntshav siab, bradyarrhythmia).

Los ntawm lub plab zom mov: dyspepsia (xeev siab, zawv plab, zoo nkaus li qhov hnyav hauv lub phaum epigastrium, saj "xim hlau" hauv qhov ncauj), qab los noj tsawg (qhov tsis zoo ntawm cov tshuaj no yuav txo qis nrog cov tshuaj thaum noj mov), tsis tshua muaj kab mob siab, mob siab daj ntseg (noj tshuaj tawm) , nce kev ua si ntawm hepatic transaminases, alkaline phosphatase.

Los ntawm cov kab mob hemopoietic: tsis tshua muaj - inhibition ntawm cov pob txha mob hematopoiesis (ntshav liab, thrombocytopenia, leukopenia).

Ua xua: khaus, urticaria, maculopapular pob.

Lwm yam: tsis pom kev pom.

Cov lus qhia tshwj xeeb

Glimecomb tuaj yeem tsuas yog kho rau cov neeg mob tau txais kev noj mov tsis tu ncua, uas tsim nyog noj tshais thiab muab cov khoom noj txaus rau hauv kev noj haus.

Kev sib txuam

Kev ntxiv dag zog rau cov nyhuv hypoglycemic ntawm cov tshuaj Glimecomb tau pom nrog tib lub sijhawm siv nrog ACE inhibitors (captopril, enalapril), histamine H2-receptor blockers (cimetidine), tshuaj tua kab mob (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropenbibazone ), tshuaj tiv thaiv kab mob TB (ethionamide), salicylates, coumarin anticoagulants, anabolic steroids, beta-blockers, MAO inhibitors, sulfonamides ntev ntev , nrog cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyridoxine, nrog rau lwm yam tshuaj hypoglycemic, t. Cov.

Kev txo qis hauv cov nyhuv hypoglycemic ntawm cov tshuaj Glimecomb tau pom nrog tib lub sijhawm siv nrog barbiturates, GCS, adrenergic agonists (epinephrine, clonidine), antiepileptic tshuaj (phenytoin), nrog qeeb calcium calcium blockers, carbonic anhydrase inhibitors, acetazolamide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide di-amide nrog baclofen, danazole, diazoxide, isoniazid, nrog morphine, ritodrin, salbutamol, terbutaline, nrog glucagon, rifampicin, nrog rau cov thyroid hormones. s, cov roj ntsha kua qaub, nrog cov koob tshuaj nicotinic acid ntau heev, chlorpromazine, tshuaj muaj qhov ncauj thiab estrogens.

Ua rau muaj kev pheej hmoo ntawm ventricular extrasystole nyob rau tom qab ntawm cov mob glycosides.

Cov tshuaj noj uas ua kom cov leeg hlwb hematopoiesis ua rau muaj kev pheej hmoo ntawm myelosuppression.

Ethanol tsub kom muaj feem ntau ntawm cov kab mob lactic acidosis.

Cov lus nug, lus teb, tshuaj xyuas ntawm tshuaj Glimecomb

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Cov lus qhia phau ntawv

Tus tswv ntawm daim ntawv pov thawj rau npe: Tshuaj thiab Kws Tshuaj Ua ke Akrikhin, OJSC (Russia)
Sawv Cev: Akrikhin OJSC (Russia)

Daim ntawv tso tawm
Ntsiav tshuaj 40 mg + 500 mg: 60 pcs.

Sib xyaw tshuaj hypoglycemic rau kev siv lub qhov ncauj. Glimecomb® yog kev sib xyaw ua ke ntawm ob lub qhov ncauj hypoglycemic ntawm cov pab pawg biguanide thiab sulfonylurea pawg.

Nws muaj pancreatic thiab extrapancreatic kev txiav txim.

Glyclazide yog sulfonylurea derivative. Tsim kho thaj ua rau cov insulin los ntawm cov txiav, nce ntxiv ntawm qhov tsis haum ntawm cov ntaub so ntswg mus rau insulin. Tsim kho kev ua ub no ntawm intracellular enzymes - nqaij hlav glycogen synthetase. Nws rov kho lub sijhawm thaum kawg ntawm cov tshuaj insulin secretion, txo lub sijhawm ncua sijhawm ntawm lub sijhawm noj mov kom txog thaum pib lub cev insulin, thiab txo qis postprandial hyperglycemia. Ntxiv nrog rau cuam tshuam rau cov metabolism hauv kev ua haujlwm, nws cuam tshuam microcirculation, txo platelet adhesion thiab kev sib sau ua ke, qeeb kev txhim kho ntawm parietal thrombosis, normalizes vascular permeability thiab inhibits kev txhim kho ntawm microthrombosis thiab atherosclerosis, rov qab cov txheej txheem ntawm physiological parietal fibrinolysis, thiab tawm tsam cov tshuaj tiv thaiv muaj zog rau vascular adrenal. Txo cov kev loj hlob ntawm cov ntshav qab zib retinopathy nyob rau theem tsis-loj hlob, nrog cov ntshav qab zib nephropathy nrog kev siv lub sijhawm ntev, qhov tseem ceeb txo qis rau cov proteinuria tau sau tseg. Nws tsis ua rau kom nce hauv lub cev nyhav, vim nws muaj cov teebmeem tseem ceeb ntawm kev xav thaum ntxov ntawm insulin secretion thiab tsis ua rau hyperinsulinemia, pab txo lub cev qhov hnyav hauv cov neeg mob rog, ua raws li kev noj zaub mov kom tsim nyog.

Metformin belongs rau cov pab pawg ntawm cov loj loj. Nws txo cov concentration ntawm cov piam thaj hauv cov ntshav los ntawm inhibiting gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm cov hnyuv thiab ua kom nws cov kev siv hauv cov ntaub so ntswg. Nws txo qhov concentration ntawm triglycerides, roj (cholesterol) thiab LDL (txiav txim siab ntawm lub plab khoob) hauv cov ntshav cov ntshav thiab tsis hloov lub siab ntawm lipoproteins ntawm ntau qhov sib txawv. Pab ua kom ruaj khov lossis txo lub cev qhov hnyav. Thaum tsis muaj cov tshuaj insulin nyob rau hauv cov ntshav, kev kho mob tsis pom tseeb. Kev ua kom lub cev ntshav qis tsis tuaj yeem ua. Txhim kho cov khoom fibrinolytic ntawm cov ntshav vim yog kev tsuj ntawm ib qho inhibitor ntawm tus activator profibrinolysin (plasminogen) cov ntaub so ntswg hom.

Xuas thiab faib khoom

Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus tau yog siab. Thaum noj nyob rau hauv ib koob ntawm 40 mg C max hauv cov ntshav plasma tau mus txog tom qab 2-3 teev thiab ntau npaum li 2-3 μg / ml. Plasma protein khi yog 85-97%.

Kev ntsuas phoo thiab nthuav tawm

Cov tshuaj txiav tawm hauv daim siab. T 1/2 - 8-20 teev. Nws raug nthuav tawm ntau hauv cov qauv ntawm cov khoom siv metabolites los ntawm ob lub raum - 70%, los ntawm txoj hnyuv - 12%.

Hauv cov neeg mob laus, cov kab mob tseem ceeb hloov hauv pharmacokinetic tsis tau pom.

Xuas thiab faib khoom

Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus tau yog 48-52%. Sai sai nqus los ntawm cov hnyuv. Kev tsis txaus siab txog kev noj qab haus huv (ntawm lub plab khoob) yog 50-60%. C max hauv cov ntshav ntshav tau mus txog tom qab 1.81-2.69 h thiab tsis pub tshaj 1 μg / ml. Txais tos nrog cov zaub mov txo C max hauv plasma los ntawm 40% thiab txo nws qhov ua tiav los ntawm 35 feeb. Plasma protein khi yog negligible. Metformin muaj peev xwm khaws ntau ntxiv hauv cov ntshav liab.

T 1/2 yog 6.2 teev .Nws yog tawm los ntawm lub raum, feem ntau tsis hloov pauv (glomerular pom thiab tubular tso zis) thiab los ntawm cov hnyuv (txog 30%).

- hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) nrog qhov tsis muaj txiaj ntsig ntawm kev kho kev noj haus, kev tawm dag zog thiab kev kho mob yav dhau los nrog metformin lossis gliclazide,

- hloov kev kho mob yav dhau los nrog ob yam tshuaj (metformin thiab gliclazide) hauv cov neeg mob uas muaj ntshav qab zib hom 2 (tsis-insulin-tiv thaiv) nrog cov ntshav khov thiab tswj tau ntshav qabzib.

Feem ntau cov tshuaj no yuav noj 2 zaug / hnub (sawv ntxov thiab yav tsaus ntuj).

Los ntawm ib sab ntawm cov metabolism: hauv qee kis - lactic acidosis (tsis muaj zog, myalgia, ua pa tsis haum, tsaug zog, mob plab, hypothermia, txo ntshav siab, bradyarrhythmia).

Los ntawm cov kab mob hemopoietic: tsis tshua muaj - inhibition ntawm cov pob txha mob hematopoiesis (ntshav liab, thrombocytopenia, leukopenia).

Ua xua: khaus, urticaria, maculopapular pob.

Lwm yam: tsis pom kev pom.

Yog tias muaj kev mob tshwm sim, qhov tshuaj yuav tsum raug txo lossis cov tshuaj txuas mus ntxiv ib ntus.

Cov kev mob tshwm sim ntawm sulfonylurea derivatives: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, kev tsis haum vasculitis, ua rau lub siab ua rau lub siab tsis ua haujlwm.

- yam 1 mob ntshav qab zib mellitus (insulin-dependant),

- kuaj ntshav qab zib, mob ntshav qab zib tsis xeev,

- Lub raum khiav tsis zoo,

- mob nyhav uas tuaj yeem ua rau lub raum pauv hloov: lub cev qhuav dej, ua mob hnyav, ceeb,

- mob ceev lossis mob ntev nrog cov nqaij mos hypoxia: lub plawv tsis ua haujlwm, ua pa tsis ua haujlwm, tsis ntev los no myocardial infarction, poob siab,

- lactation (pub niam mis),

- tib lub sijhawm tswj hwm ntawm miconazole,

- tej yam mob uas yuav tsum tau kho cov tshuaj insulin, suav nrog kis kab mob sib kis, kev phais mob hnyav, kev raug mob, kev kub nyhiab,

- qaug cawv ua rau qaug cawv,

- lactic acidosis (suav nrog keeb kwm),

- siv tsawg kawg 48 teev ua ntej thiab nyob rau hauv 48 teev tom qab ua kev tshawb fawb radioisotope lossis X-ray nrog kev qhia ntawm iodine-contrast contrast medium,

- kev ua raws li kev noj zaub mov kom tsis txhob muaj calories ntau tsawg (tsawg dua 1000 cal / hnub),

- Cov tshuaj tiv thaiv tsis haum rau cov tshuaj,

- Cov tshuaj tiv thaiv tsis haum rau lwm cov sulfonylurea derivatives.

Nws tsis pom zoo kom siv cov tshuaj hauv cov neeg mob laus dua 60 xyoo uas ua haujlwm lub cev hnyav, uas cuam tshuam nrog kev pheej hmoo ntawm cov kab mob lactic acidosis.

Nrog kev ceev faj, cov tshuaj yuav tsum tau siv nyob rau hauv cov ntaub ntawv ntawm febrile syndrome, adrenal tsis txaus, hypofunction ntawm anterior pituitary, kab mob ntawm cov thyroid caj pas nrog kev ua haujlwm tsis zoo.

Kev siv ntawm cov tshuaj Glimecomb ® thaum cev xeeb tub yog contraindicated. Thaum npaj kev cev xeeb tub, nrog rau kev xeeb tub thaum lub sijhawm noj cov tshuaj Glimecomb ®, nws yuav tsum tau txiav tawm thiab kev kho mob insulin yuav tsum tau kho.

Glimecomb ® yog qhov sib txuam hauv kev pub niam mis, vim tias cov tshuaj yeeb dej caw tuaj yeem tawm hauv niam mis. Hauv qhov no, koj yuav tsum hloov mus rau kev siv tshuaj insulin lossis txwv kev pub niam mis.

Cov tsos mob: lactic acidosis yog ua tau (vim tias metformin yog ib feem ntawm cov tshuaj), mob ntshav qab zib tsawg.

Kev Kho Mob: Thaum cov tsos mob ntawm tus mob lactic acid tshwm sim, koj yuav tsum tsis txhob noj tshuaj. Lactic acidosis yog kev mob uas yuav tsum tau txais kev kho mob xwm txheej ceev, kev kho mob yog nqa tawm hauv tsev kho mob. Qhov kev kho mob uas zoo tshaj plaws yog hemodialysis.

Nrog rau cov ntshav qog ntshav qab zib me lossis mob ntshav qab zib ntau, cov piam thaj (dextrose) los yog cov kua qab zib yog noj ntawm qhov ncauj. Thaum muaj mob ntshav qab zib tsawg (tsis nco qab lawm), 40% dextrose (qabzib) lossis iv glucagon, i / m lossis s / c yog txhaj iv. Tom qab nws rov qab nco qab, tus neeg mob yuav tsum tau muab cov zaub mov nplua nuj nyob hauv cov khoom noj kom hnyav kom tsis txhob muaj kev rov qab txhim kho ntawm hypoglycemia.

Ntxiv dag zog rau qhov kev tiv thaiv hypoglycemic ntawm cov tshuaj Glimecomb ® tau pom nrog tib lub sijhawm siv nrog ACE inhibitors (captopril, enalapril), histamine H 2 receptor blockers (cimetidine), tshuaj tua kab mob (miconazole, fluconazole), NSAIDs (phenylbutazone, oxapropibone, az) , bezafibrat), tshuaj tiv thaiv TB (ethionamide), salicylates, coumarin anticoagulants, anabolic steroids, beta-blockers, MAO inhibitors, ntev sulfonamides vii, nrog cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyridoxine, nrog rau lwm cov tshuaj hypoglycemic, oxytetracycline.

Kev txo qis hauv cov nyhuv hypoglycemic ntawm cov tshuaj Glimecomb ® tau pom nrog tib lub sijhawm siv nrog barbiturates, GCS, adrenergic agonists (epinephrine, clonidine), tshuaj antiepileptic (phenytoin), nrog qeeb calcium calcium blockers, carbonic anhydrase inhibitors, acetyl azidemide diuretics, triaz , nrog baclofen, danazole, diazoxide, isoniazid, nrog morphine, ritodrin, salbutamol, terbutaline, nrog glucagon, rifampicin, nrog rau cov thyroid hormones. zy, lithium ntsev, muaj koob nicotinic acid, chlorpromazine, qhov ncauj contraceptives thiab estrogens.

Ua rau muaj kev pheej hmoo ntawm ventricular extrasystole nyob rau tom qab ntawm cov mob glycosides.

Cov tshuaj noj uas ua kom cov leeg hlwb hematopoiesis ua rau muaj kev pheej hmoo ntawm myelosuppression.

Ethanol tsub kom muaj feem ntau ntawm cov kab mob lactic acidosis.

Metformin txo C max hauv ntshav thiab T 1/2 ntawm furosemide los ntawm 31 thiab 42.3%, feem.

Furosemide nce C max metformin los ntawm 22%.

Nifedipine nce ntxiv kev nqus, nce C max hauv ntshav ntshav, thiab maj mam nqes ntawm qhov tsis pom ntawm metformin.

Cov tshuaj Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren thiab vancomycin) zais cia rau hauv cov tubules sib tw rau cov tub ntxhais thauj khoom thiab, nrog kev kho mob ntev, tuaj yeem nce C max metformin hauv ntshav ntshav los ntawm 60%.

Contraindicated nyob rau hauv daim siab tsis ua hauj lwm.

Ua rau lub raum khiav tsis zoo, mob hnyav uas tuaj yeem ua rau lub raum hloov pauv: lub cev qhuav dej, kis tau hnyav, poob siab.

Kev Kho Mob nrog Glimecomb ® tsuas yog ua rau kev sib xyaw nrog kev noj zaub mov kom muaj calorie tsawg, carb cov pluas noj qis. Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam qib ntshav qabzib hauv cov ntshav ntawm lub plab khoob thiab tom qab noj mov, tshwj xeeb tshaj yog nyob rau thawj hnub ntawm kev kho mob nrog tshuaj.

Glimecomb ® tuaj yeem tsuas yog kho rau cov neeg mob tau txais kev noj mov tsis tu ncua, uas suav nrog noj tshais thiab muab cov khoom noj txaus rau hauv kev noj haus.

Thaum sau tshuaj, nws yuav tsum tau yug los rau hauv lub siab hais tias vim kev noj cov tshuaj sulfonylurea derivatives, hypoglycemia tuaj yeem txhim kho, thiab hauv qee kis muaj mob hnyav thiab ntev, yuav tsum tau pw hauv tsev kho mob thiab ntshav qabzib rau ob peb hnub. Kev mob ntshav qab zib feem ntau pib txhim kho nrog cov zaub mov tsis muaj calorie, tom qab ua haujlwm ntev lossis ua kom ib ce muaj zog, tom qab haus dej haus cawv, lossis thaum noj ntau yam tshuaj hypoglycemic nyob rau tib lub sijhawm. Txhawm rau kom zam dhau kev txhim kho hypoglycemia, yuav tsum ceev faj thiab xaiv ib koob tshuaj yuav tsum tau, nrog rau kev muab tus neeg mob nrog cov ntaub ntawv tiav ntawm cov kev kho mob uas tau thov. Nrog rau kev tawm dag zog ntawm lub cev thiab lub siab, thaum hloov kev noj zaub mov, kev hloov kho tshuaj ntawm cov tshuaj Glimecomb ® yog qhov tsim nyog.

Beta-blockers, clonidine, reserpine, guanethidine tuaj yeem npog qhov chaw kho mob tshwm sim ntawm hypoglycemia.

Cov neeg mob yuav tsum ceeb toom qhia txog kev pheej hmoo yuav muaj ntshav qab zib tsawg nyob rau hauv muaj ethanol, NSAIDs, thiab tshaib plab.

Nrog kev phais mob ntau thiab kev raug mob, kub hnyiab ntev, kis kab mob nrog febrile syndrome, nws yuav tsum tso tshuaj kom qhov ncauj tsis zoo thiab kho tshuaj insulin.

48 teev ua ntej kev phais lossis nyob rau hauv / hauv kev qhia txog ntawm iodine-muaj radiopaque tus neeg sawv cev, cov tshuaj Glimecomb ® yuav tsum tsis ua mus ntxiv. Txoj kev kho yog pom zoo kom rov hais dua tom qab 48 teev.

Tawm tsam keeb kwm ntawm kev kho nrog Glimecomb ®, tus neeg mob yuav tsum tso tseg txoj kev siv cawv thiab / lossis cov tshuaj uas muaj cawv thiab zaub mov.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Thaum lub sijhawm kho mob, yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm yam kev phom sij uas yuav tsum muaj kev mloog zoo thiab ceev ntawm cov kev tiv thaiv psychomotor.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Ntsiav tshuaj los ntawm dawb mus dawb nrog creamy lossis daj daj zas, pav ca-lub tog raj kheej, nrog chamfer thiab nqis siab tshaj, marbling raug tso cai.

1 tab
gliclazide	40 mg
metformin hydrochloride	500 mg

Cov muaj mob siab: sorbitol, povidone, croscarmellose sodium, magnesium stearate.

10 Pcs - blister packagings (6) - pob ntawv ntawm cardboard.

Pharmacological kev txiav txim

Sib xyaw tshuaj hypoglycemic rau kev siv lub qhov ncauj. Glimecomb® yog kev sib xyaw ua ke ntawm ob lub qhov ncauj hypoglycemic ntawm cov pab pawg biguanide thiab sulfonylurea pawg.

Nws muaj pancreatic thiab extrapancreatic kev txiav txim.

Glyclazide - sulfonylurea derivative. Tsim kho thaj ua rau cov insulin los ntawm cov txiav, nce ntxiv ntawm qhov tsis haum ntawm cov ntaub so ntswg mus rau insulin. Tsim kho kev ua ub no ntawm intracellular enzymes - nqaij hlav glycogen synthetase.

Nws rov kho lub sijhawm thaum kawg ntawm cov tshuaj insulin secretion, txo lub sijhawm ncua sijhawm ntawm lub sijhawm noj mov kom txog thaum pib lub cev insulin, thiab txo qis postprandial hyperglycemia.

Ntxiv nrog rau cuam tshuam rau cov metabolism hauv kev ua haujlwm, nws cuam tshuam microcirculation, txo platelet adhesion thiab kev sib sau ua ke, qeeb kev txhim kho ntawm parietal thrombosis, normalizes vascular permeability thiab inhibits kev txhim kho ntawm microthrombosis thiab atherosclerosis, rov qab cov txheej txheem ntawm physiological parietal fibrinolysis, thiab tawm tsam cov tshuaj tiv thaiv muaj zog rau vascular adrenal. Txo cov kev loj hlob ntawm cov ntshav qab zib retinopathy nyob rau theem tsis-loj hlob, nrog cov ntshav qab zib nephropathy nrog kev siv lub sijhawm ntev, qhov tseem ceeb txo qis rau cov proteinuria tau sau tseg. Nws tsis ua rau kom nce hauv lub cev nyhav, vim nws muaj cov teebmeem tseem ceeb ntawm kev xav thaum ntxov ntawm insulin secretion thiab tsis ua rau hyperinsulinemia, pab txo lub cev qhov hnyav hauv cov neeg mob rog, ua raws li kev noj zaub mov kom tsim nyog.

Metformin belongs rau cov pab pawg ntawm biguanides. Nws txo cov concentration ntawm cov piam thaj hauv cov ntshav los ntawm inhibiting gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm cov hnyuv thiab ua kom nws cov kev siv hauv cov ntaub so ntswg.

Nws txo qhov concentration ntawm triglycerides, roj (cholesterol) thiab LDL (txiav txim siab ntawm lub plab khoob) hauv cov ntshav cov ntshav thiab tsis hloov lub siab ntawm lipoproteins ntawm ntau qhov sib txawv. Pab ua kom ruaj khov lossis txo lub cev qhov hnyav. Thaum tsis muaj cov tshuaj insulin nyob rau hauv cov ntshav, kev kho mob tsis pom tseeb. Kev ua kom lub cev ntshav qis tsis tuaj yeem ua.

Txhim kho cov khoom fibrinolytic ntawm cov ntshav vim yog kev tsuj ntawm ib qho inhibitor ntawm tus activator profibrinolysin (plasminogen) cov ntaub so ntswg hom.

Cov Tshuaj Pharmacokinetics

Xuas thiab faib khoom

Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus tau yog siab. Thaum noj nyob rau hauv ib koob ntawm 40 mg Cmax hauv ntshav tau txog tom qab 2-3 teev thiab ntau npaum li 2-3 μg / ml. Plasma protein khi yog 85-97%.

Kev ntsuas phoo thiab nthuav tawm

Cov tshuaj txiav tawm hauv daim siab. T1 / 2 - 8-20 teev. Nws raug nthuav tawm feem ntau hauv cov qauv ntawm cov khoom siv tshuaj tiv thaiv los ntawm lub raum - 70%, dhau los ntawm txoj hnyuv - 12%.

Hauv cov neeg mob laus, cov kab mob tseem ceeb hloov hauv pharmacokinetic tsis tau pom.

Xuas thiab faib khoom

Tom qab kev tswj hwm ntawm qhov ncauj, qhov nqus tau yog 48-52%. Sai sai nqus los ntawm cov hnyuv. Kev tsis txaus siab txog kev noj qab haus huv (ntawm lub plab khoob) yog 50-60%. Cmax hauv cov ntshav plasma tau mus txog tom qab 1.81-2.69 h thiab tsis pub tshaj 1 μg / ml. Txais tos nrog cov zaub mov txo Cmax hauv plasma los ntawm 40% thiab txo nws qhov ua tiav los ntawm 35 min. Plasma protein khi yog negligible. Metformin muaj peev xwm khaws ntau ntxiv hauv cov ntshav liab.

T1 / 2 yog 6.2 teev .Nws yog tawm los ntawm lub raum, feem ntau tsis hloov pauv (glomerular pom thiab tubular tso zis) thiab los ntawm cov hnyuv (txog 30%).

Noj ntau dhau

Cov tsos mob lactic acidosis muaj peev xwm ua tau (txij li metformin yog ib feem ntawm cov tshuaj), hypoglycemia.

Kev Kho Mob: yog tias cov tsos mob ntawm mob lactic acid tshwm sim, tsum tsis txhob siv tshuaj. Lactic acidosis yog kev mob uas yuav tsum tau txais kev kho mob xwm txheej ceev, kev kho mob yog nqa tawm hauv tsev kho mob. Qhov kev kho mob uas zoo tshaj plaws yog hemodialysis.

Yeeb tshuaj sib cuam tshuam

Ua rau muaj kev pheej hmoo ntawm ventricular extrasystole nyob rau tom qab ntawm cov mob glycosides.

Cov tshuaj noj uas ua kom cov leeg hlwb hematopoiesis ua rau muaj kev pheej hmoo ntawm myelosuppression.

Ethanol tsub kom muaj feem ntau ntawm cov kab mob lactic acidosis.

Metformin txo Cmax hauv ntshav thiab T1 / 2 ntawm furosemide los ntawm 31 thiab 42.3%, ntsig txog.

Furosemide nce Cmax ntawm metformin los ntawm 22%.

Nifedipine nce ntxiv kev nqus, nce Cmax hauv ntshav plasma, ua rau qis qis tsis txaus tawm ntawm metformin.

Cev xeeb tub thiab lactation

Cov lus thiab cov xwm txheej ntawm kev cia

Sau npe B. Cov tshuaj yuav tsum muab cia kom ncav tsis cuag ntawm cov menyuam yaus, qhuav, tiv thaiv los ntawm lub teeb, ntawm qhov kub tsis tshaj 25 ° C. Txee lub neej yog 2 xyoos.

Cov lus piav qhia ntawm cov tshuaj GLIMECOMB yog ua raws li cov lus qhia raug pom zoo rau kev siv thiab pom zoo los ntawm cov kws tsim khoom.

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Cov kev cai rau noj cov tshuaj Glimecomb thiab cov tshuaj analog

Glimecomb hais txog cov tshuaj uas siv rau ntshav qab zib hom 2.

Lub cuab yeej muaj qhov ua ke nrog hypoglycemic cov cuab yeej.

Tom qab noj cov tshuaj, qhov ib txwm ua tsis tiav ntawm cov piam thaj hauv tus neeg mob cov ntshav tau sau tseg.

Cov ntaub ntawv dav dav, muaj pes tsawg leeg thiab daim ntawv tso tawm

Cov tshuaj tshwj xeeb hais txog cov neeg sawv cev hypoglycemic coj noj ntawm qhov ncauj. Cov cuab yeej muaj kev sib koom ua ke. Ntxiv nrog rau cov nyhuv qab zib-qis, Glimecomb muaj cov nyhuv ua pancreatic. Hauv qee kis, cov tshuaj muaj cov nyhuv ntxiv.

Cov tshuaj muaj pes tsawg leeg muaj cov tshuaj Metformin hydrochloride ntau npaum li 500 mg thiab Gliclazide - 40 mg, thiab ntxiv rau cov neeg tsis muaj txiaj ntsig sorbitol thiab croscarmellose sodium. Txo me me, magnesium stearate thiab povidone muaj nyob hauv cov tshuaj.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj ntsiav cylindrical hauv dawb, qab zib lossis daj ntxoov. Rau cov ntsiav tshuaj, marbling yog tau. Tshuaj tua kab mob muaj qhov pheej hmoo thiab ib qho bevel.

Glimecomb raug muag hauv 10 ntsiav tshuaj hauv qhov hlwv blister. Ib pob muaj 6 pob.

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Glimecomb yog ib hom tshuaj uas ua ke nrog cov tshuaj hypoglycemic ntawm biguanide pawg thiab sulfonylurea derivatives.

Tus neeg sawv cev yog tus cwj pwm los ntawm pancreatic thiab ntxiv cov teebmeem ntxiv.

Gliclazide yog ib yam khoom tseem ceeb ntawm cov tshuaj. Nws yog sulfonylurea derivative.

nquag insulin ntau lawm
txo cov ntshav piam thaj concentration,
txo cov platelet adhesion, uas tiv thaiv kev tsim cov ntshav txhaws hauv cov hlab ntshav,
normalization ntawm vascular permeability.

Gliclazide inhibits qhov tshwm sim ntawm microthrombosis. Thaum lub caij nyoog siv cov tshuaj hauv cov neeg mob ntshav qab zib nephropathy, kev txo qis ntawm cov proteinuria (muaj cov protein nyob hauv cov zis) tau pom.

Gliclazide cuam tshuam qhov hnyav ntawm tus neeg mob noj cov tshuaj. Nrog rau cov khoom noj kom haum rau cov neeg mob ntshav qab zib noj Glimecomb, qhov hnyav yog sau tseg.

Metformin, uas yog ib feem ntawm cov tshuaj, yog hais txog cov pab pawg biguanide. Cov tshuaj yuav pab txo cov piam thaj hauv cov ntshav, pab ua kom txoj kev nqus ntawm cov piam thaj hauv plab thiab cov hnyuv. Metformin pab ceev cov txheej txheem ntawm kev siv cov kua nplaum los ntawm cov nqaij hauv lub cev.

Qhov tshuaj txo qis cov roj cholesterol, cov lipoproteins tsawg tsawg. Hauv qhov no, Metformin tsis cuam tshuam rau theem ntawm lipoproteins ntawm ntau qhov sib txawv. Zoo li Gliclazide, nws txo qhov hnyav ntawm tus neeg mob.

Nws tsis muaj dab tsi tshwm sim thaum tsis muaj insulin hauv cov ntshav. Tsis pab ua rau pom ntawm hypoglycemic kev tshwm sim. Gliclazide thiab metformin sib txawv nqus thiab ua rau tus neeg mob siab.

Gliclazide yog tus cwj pwm los ntawm kev nqus ntau dua li ntawm Metformin.

Qhov siab tshaj plaws ntawm Gliclazide hauv cov ntshav tau mus txog tom qab 3 teev txij li lub sijhawm ntawm kev noj tshuaj. Cov tshuaj no dhau los ntawm lub raum (70%) thiab cov hnyuv (12%). Qhov kev tshem tawm ib nrab-lub neej ncav 20 teev.

Qhov txheeb ntawm cov xyoob ntoo ntawm Metformin yog 60%. Cov tshuaj nquag txuam nrog rau cov ntshav liab. Ib nrab-lub neej yog 6 teev. Kev rho tawm hauv lub cev tshwm sim los ntawm lub raum, nrog rau txoj hnyuv (30%).

Kev taw qhia thiab contraindications

Cov tshuaj yog pom zoo rau cov neeg mob ntshav qab zib nrog hom ntshav qab zib hom 2 yog tias:

kev kho mob dhau los nrog rau kev noj haus thiab ce tsis muaj qhov ua kom zoo,
muaj qhov xav tau los hloov kev kho ua ke dhau los siv kev siv Gliclazide nrog Metformin hauv cov neeg mob uas muaj cov ntshav qabzib nyob ruaj.

Cov tshuaj yog tus cwj pwm los ntawm cov kev qhia ntau yam ntawm contraindications, uas:

muaj cov ntshav qab zib hom 1,
tus kheej intolerance mus rau lub Cheebtsam ntawm cov tshuaj,
raum tsis ua hauj lwm zoo,
cev xeeb tub
daim siab ua hauj lwm
lactic acidosis,
lub plawv tsis ua hauj lwm
mob ntshav qab zib coma
kev pub mis
ntau yam kab mob
myocardial infarction
Kab mob porphyrin
kuaj mob ntshav qab zib
yav dhau los phais
lub sijhawm ntawm tus neeg mob mus kuaj xoo hluav taws xob thiab kev soj ntsuam siv cov khoom siv radioisotopes nrog kev qhia txog iodine-cov tshuaj uas tsis zoo rau hauv lub cev (nws yog txwv tsis pub noj 2 hnub ua ntej thiab tom qab cov kev tshawb fawb no),
raug mob hnyav
poob siab mob tiv thaiv keeb kwm ntawm kab mob hauv lub plawv thiab raum,
ua pa tsis ua hauj lwm
cawv intoxication,
cov piam thaj hauv ntshav tsawg (hypoglycemia),
mob raum zoo
haus cawv ntev,
nws kim heev hlawv lub cev,
mas ua raws cov neeg mob hypocaloric noj,
noj miconazole,
mob ketoacidosis.

Kev xav ntawm cov kws tshaj lij thiab cov neeg mob

Los ntawm kev tshuaj xyuas cov neeg mob, nws tuaj yeem xaus lus tias Glimecomb txo cov ntshav qab zib kom zoo thiab muaj kev zam zoo, txawm li cas los xij, cov kws kho mob hais kom nws ceev faj vim muaj ntau cov kev mob tshwm sim.

Cov tshuaj uas tshwj xeeb yog faib los ntawm cov tshuaj. Nws tus nqi yog li ntawm 440-580 rubles. Tus nqi ntawm lwm cov khoom lag luam hauv tsev yog ntawm 82 txog 423 rubles.

Pom zoo Lwm Yam Lus Txog

Glimecomb: cov lus qhia rau kev siv, tus nqi, xyuas, cov analogues

Cov tshuaj ua rau qhov ncauj, tsom rau tswj cov theem ntawm cov piam thaj hauv cov ntshav ntawm tus neeg mob ntshav qab zib hom 2.

Ua ke ob qho Metformin thiab Gliclazide, Glimecomb yog ib qho kev daws teeb meem zoo rau cov teeb meem ntshav qab zib, kev tswj hwm ntawm qhov yuav tsum yooj yim rau kev tswj hwm.

Tom qab tag nrho, cov cuab yeej no tsis muaj hwj chim, thiab yog li ntawd tsis haum cov neeg mob uas tsis khov thiab ua kom nce siab hauv cov suab thaj. Cov hauv qab no yog cov tseev kom muaj uas yuav tsum tau ua thaum siv cov tshuaj no.

Thov

Glimecomb raug pom zoo rau siv rau hauv cov neeg mob uas kuaj pom tus mob ntshav qab zib hom 2.

Nws yog ib qho tseem ceeb tias cov tshuaj no yog tsom rau xws li kev mob tshwm sim thaum muaj kev tawm dag zog thiab daim ntawv qhia zaub mov tshwj xeeb tsis coj cov txiaj ntsig tsim nyog.

Qhov no txhais tau hais tias cov tshuaj no tau sau tseg rau hauv kev ua tsis tiav ntawm kev kho txoj kev kho mob, sib txuas nrog ob yam tshuaj (feem ntau sib cais nrog metformin thiab gliclazide) nrog rau kev ua haujlwm ntawm lub cev thiab kev noj haus.

Thaum kho nrog Glimecomb, kev tshuaj xyuas cov ntshav qab zib kom tsawg ntawm tus neeg mob ua ntej thiab tom qab noj mov yog qhov tsim nyog (tshwj xeeb yuav tsum them rau thawj lub lim tiam ntawm kev nkag mus).

Tso Tawm Cov Ntawv

Glimecomb muaj kev tso tawm ib qho hauv daim ntawv ntawm cov ntsiav tshuaj. Cov tshuaj raug faib los ntawm cov txheej txheem ntawm kev ntim rau hauv cov pawg hauv qab no:

hauv cov yas hwj hauv pob ntawv thawv. Ib lub vial ntawd ntim tau 30, 60 lossis 120 ntsiav tshuaj,
hauv daim thawv ntawv thawv nrog blisters ntawm 10 ntsiav tshuaj hauv ib qho. Ib pob muaj 6 lub hlwv,
nyob rau hauv ib lub thawv ntawv thawv nrog lub hlwv ntawm 20 ntsiav tshuaj hauv ib qho. Ib lub pob ntawd muaj 5 lub hlwv.

Cov ntsiav tshuaj lawv tus kheej yog nyob rau hauv daim ntawv ntawm cov tiaj tus kheej kheej, feem ntau dawb (beige, marble lossis daj yog siv tau). Tshuaj tua kab mob muaj qhov pheej hmoo thiab ib qho bevel. Qhov sib xyaw ua ke ntawm Glimecomb suav nrog metformin thiab hydrochloride hauv ib qho npaum li 500 mg, zoo li glycoslide 40 mg. Tsis tas li ntawd, povidone, magnesium stearate, sorbitol thiab croscarmellose sodium yog tam sim no cov khoom me me.

Cov ntsiav tshuaj tsuas yog muaj nyob ntawm cov tshuaj.

Sab sij huam

Cov kev mob tsis txaus siab uas tuaj yeem ntsib thaum noj Glimecomb feem ntau vim tias nws noj ntau dhau lossis tsis sib xws nrog tus neeg mob lub cev tshwj xeeb.

Thiab cov ntsiab lus ntawm sulfonylurea derivatives ua rau muaj kev pheej hmoo ntau ntawm cov kev mob tshwm sim.

Kev xaiv koob tsis raug rau tus neeg mob yog fraught nrog kev txhim kho ntawm cov kab mob lactic acidosis, nrog rau yastaw yauv tawm, tsis muaj zog ib ce, qhov siab ntawm nkees, nrog rau kev txiav mob rau hauv thaj chaw hauv plab thiab txo qis siab hauv cov hlab ntsha.

Cov hauv qab no yog cov tsis xav tau qhov cuam tshuam thaum noj Glimecomb:

kev txhim kho ntawm hypoglycemia thiab lactocidosis nrog txhua yam mob mob tshwm sim,
cov tsos ntawm zawv plab thiab flatulence,
tas li tsis kaj siab lom zem nyob rau hauv lub plab kab noj hniav,
txo hauv kev tshaib plab,
qee zaus tshwm sim ntawm kev saj ntawm cov ntshav hauv lub qhov ncauj thiab lub caj pas,
kev txhim kho ntawm daim siab mob siab (kab mob siab, thiab lwm yam) muaj tsawg
kev tsis haum tshuaj rau cov khoom siv ntawm cov muaj pes tsawg leeg (urticaria, khaus, qog,
ua pob liab liab, ntau hom pob khaus),
muaj cov xwm txheej tsis pom kev zoo thaum noj Glimecomb.

Yog tias koj muaj cov tsos mob saum toj no, koj yuav tsum tau sab laj nrog tus kws kho mob tshwj xeeb.

Ua raws li qhov mob hnyav ntawm kev mob tshwm sim, tus kws kho mob yuav tsum txo qhov ntau npaum li cas ntawm cov tshuaj lossis hloov nws nrog qhov kev xaiv tau ntau dua (tag nrho tso tseg kev siv Glimecomb).

Hauv cov chaw muag tshuaj ntawm Lavxias, tus nqi ntawm Glimecomb nws txawv ntawm 200 txog 600 rubles, nyob ntawm qhov ntim thiab cov naj npawb ntawm cov ntsiav tshuaj hauv nws, ntxiv rau tus xa khoom thiab thaj chaw muag.

Tus nqi ntawm cov tshuaj no ua rau nws pheej yig heev rau ntau qhov ntawm cov pej xeem, thiab yog li ntawd hauv kev thov ntawm cov khw muag tshuaj. Yog li tus nqi nruab nrab hauv khw hauv online rau Glimecomb ntsiav tshuaj yog 40 mg + 500 mg 450 rubles rau ib pob, uas muaj 60 ntsiav tshuaj.

Hauv cov khw muag tshuaj hauv lub network, tus nqi ntawm cov tshuaj rau 60 ntsiav tshuaj yuav yog li 500-550 rubles.

Glimecomb analogues yog cov tshuaj hauv qab no:

Gliformin (txog 250 rubles rau 60 ntsiav tshuaj), lub hauv paus ntsiab lus ntawm kev ua yog tib yam li ntawm Glimecomb, qhov muaj pes tsawg leeg yog qhov zoo ib yam, tab sis qhov muaj cov tshuaj insulin ua rau cov tshuaj no tsawg dua,
Diabefarm (rau 60 ntsiav tshuaj, koj yuav tsum tau them nyiaj txog 150 rubles). Nws muaj cov tshuaj muaj zog ntau dua ntawm glyclazide - 80 mg, tsom rau kev tshem tawm tib cov teeb meem zoo li Glimecomb.
Gliclazide MV (tus nqi nruab nrab rau 60 ntsiav tshuaj yog 200 rubles). Nws muaj cov khoom sib txawv los ntawm Glimecomb, nws tsuas muaj 30 mg ntawm glycoslazide. Kev qhia rau kev siv yog tib yam li nyob hauv cov tshuaj qub.

Glimecomb: cov lus qhia rau kev siv, nqe, xyuas thiab analogues

Qee zaum cov neeg mob ntshav qab zib yuav tsum noj ntau yam tshuaj ib zaug. Tab sis muaj cov cuab yeej uas nws muaj pes tsawg leeg ua ke cov khoom tseem ceeb. Lawv cia koj ua nrog ib ntsiav tshuaj. “Glimecomb” yog yam tshuaj uas muaj cov khoom ntawd. Xav txog cov lus qhia rau nws siv ntau dua.

Piv nrog analogues

Cov tshuaj no muaj ib tug xov tooj ntawm cov analogues ob leeg hauv muaj pes tsawg leeg thiab hauv lub zog. Cia wb mus saib ze ze saib dab tsi uas Glimecomb kws kho mob tuaj yeem hloov kho.

Gliformin. Nqe - los ntawm 250 rubles rau ib pob (60 daim). Cov neeg tsim khoom ntawm JSC Akrikhin, Russia. Muaj cov tshuaj metformin. Cov yam ntxwv ntawm cov ntsiav tshuaj zoo ib yam, tab sis tsis yog rau txhua tus. Siv los tswj lub cev nyhav.

Diabefarm. Tus nqi - 160 rubles (60 ntsiav tshuaj). Cov chaw tsim khoom lag luam "Lub Chaw Muag Tshuaj", Russia. Nws muaj ntau dua gliclazide (80 mg), tus so ntawm cov khoom no zoo ib yam.

Gliclazide. Los ntawm 200 rubles rau ib pob (60 daim) Chaw tsim tshuaj paus - Canonfarm, Russia. Muaj cov gliclazide tsawg dua hauv cov tshuaj muaj pes tsawg leeg (30 mg). Pab ua kom lub cev tsis hnyav. Ib qho ntxiv ntxiv yog tus nqi qis.

Amaril. Cov ntsiav tshuaj zoo li no raug nqi los ntawm 800 rubles rau ib pob. Tsim los ntawm Handoc Inc., Kaus Lim Kauslim. Nws kuj tseem yog kev kho mob sib xyaw rau cov ntshav qab zib (glimepiride + metformin). Cov khoom sib tshuam zoo sib xws. Tus rho tawm yog qhov ntau kim.

Galvus. Tus nqi pib los ntawm 1600 rubles. Lub chaw tsim khoom yog Novartis Pharma, Lub teb chaws Yelemees. Cov tshuaj sib xyaw ua ke (vildagliptin + metformin). Nws muaj tib lub phiv thiab kev txwv rau kev nkag mus ua Glimecomb. Nws raug nqi ntau dua, tab sis qee zaus nws hloov tawm los ua haujlwm zoo dua li nws cov neeg sib tw.

Feem ntau, cov ntshav qab zib uas tau ntsib dua los tau teb rau cov tshuaj no. Qhov yooj yim ntawm kev kho mob ua ke yog sau tseg thaum ob qho tshuaj txuam nrog tib lub ntsiav tshuaj. Qee zaum lawv sau tias cov tshuaj tsis haum. Cov kev mob tshwm sim muaj tsawg.

Victor: “Kuv muaj ntshav qab zib hom 2. Kuv tau siv coj metformin thiab gliclazide cais. Nws tsis yooj yim heev thiab nws kim heev. Tus kws kho mob pauv mus rau Glimecomb. Dhau li ntawm qhov tseeb tias tam sim no kuv haus ib ntsiav tshuaj hloov ntawm ob, Kuv tseem hnov zoo dua. Kuv tsis pom muaj kev phiv dab tsi, Kuv txaus siab nrog tshuaj. "

Valeria: “Kuv txiv muaj 63 xyoos, raug kuaj mob ob peb xyoos dhau los. Ntau yam twb tau kho, txhua yam maj mam ua. Tus kws kho mob qhia kom kuv sim Glimecobm, tab sis ceeb toom tias kuv yuav tsum ua raws li kev noj haus nruj dua thiab saib xyuas kuv kev noj qab haus huv. Nws tau noj rau peb lub hlis tam sim no, cov ntsuas suab thaj nyob hauv kev txiav txim, thiab qhov hnyav poob me ntsis. Txiv zoo siab. "

Kev hlub: “Kuv tau txais kev kho mob los ntawm kev kho mob no ntev. Kuv nyiam qhov sib piv ntawm cov nqi qis thiab zoo tshaj plaws. Qab zib tsis nce, Kuv zoo heev, tsis muaj sab tshwm sim thiab tsis muaj. "

Gregory: “Tus kws kho mob tau sau npe Glimecomb. Tom qab ib hlis ntawm kev txais neeg kawm, Kuv yuav tsum tau hloov daim ntawv qhia. Kuv categorically tsis haum. Digestive teeb meem tau pib, thiab mob taub hau ntxiv rau. Tus kws kho mob hais tias tsis yog txhua tus neeg ua. Tab sis nws tsis haum rau kuv. ”

Alla: “Lawv tsa Glimecomb. Nws raug kho rau ob lub lis piam, tab sis raug yuam kom hloov mus rau lwm txoj hauv kev kho. Cov theem qab zib tsis tau pauv, ntawm qhov tsis sib xws, nws tseem nce me ntsis. Tab sis rau cov nqi ntawd nws tsis yog li hais tsis sib xws uas nws tsis haum. "

Glimecomb sib xyaw ua ke suab thaj txo qis rau cov ntshav qab zib

Mob ntshav qab zib nyob hauv lub tebchaws yog ib ntawm tsib tus kabmob tseem ceeb los ntawm peb cov neeg mob thoob ntiaj teb yog neeg xiam oob khab thiab tuag. Txawm tias raws li kev kwv yees ntxoo, txog 230 txhiab tus mob ntshav qab zib tuag txhua xyoo los ntawm cov mob ntshav qab zib nyob hauv lub tebchaws. Lawv feem ntau tsis tuaj yeem tswj hwm lawv tus mob yam tsis muaj tshuaj zoo.

Qhov nrov tshaj plaws thiab siv sijhawm kuaj ntshav qab zib-txo cov tshuaj yog los ntawm pawg biagunides thiab sulfonylureas. Lawv tau dav dav hauv kev soj ntsuam kev xyaum thiab ntau cov kev tshawb fawb, lawv tau siv nyob rau txhua theem ntawm tus mob ntshav qab zib hom 2.

Cov tshuaj sib xyaw ua ke Glimecomb (hauv cov txheej txheem thoob ntiaj teb Glimekomb) tau tsim los ntawm biagunide thiab kev npaj sulfonylurea, sib xyaw cov peev xwm ntawm metformin thiab glycazide, uas ua rau glycemia ua haujlwm zoo thiab tswj hwm.

Cov Tshuaj Kho Mob Glimecomb

Lub tshuab ntawm kev ua ntawm qhov pib npaj ntawm cov sib txawv muaj sib txawv, qhov no ua rau nws muaj peev xwm cuam tshuam cov teeb meem los ntawm ntau cov sib txawv.

Thawj cov tshuaj ntawm cov tshuaj yog tus neeg sawv cev ntawm tiam tshiab ntawm sulfonylureas. Qhov piam thaj txo qis peev xwm ntawm cov tshuaj muaj nyob rau hauv txhim kho kev tsim cov tshuaj insulin endogenous los ntawm β-hlwb ntawm cov txiav.

Ua tsaug rau kev txhawb nqa ntawm cov leeg glycogen synthase, kev siv cov kua nplaum los ntawm cov leeg nqaij tau zoo tuaj, uas txhais tau hais tias nws tsis yog li ua kom hloov mus ua rog.

Normalizes glycemic profile ntawm gliclazide hauv ob peb hnub, suav nrog ntshav qab zib metabolic ntshav qab zib.

Txij lub sijhawm tau txais cov khoom noj khoom haus hauv lub plab zom zaub mov mus rau pib ua haujlwm ntawm lawv tus kheej cov tshuaj insulin nrog rau cov tshuaj, lub sijhawm tsawg dua yog xav tau tshaj li tsis muaj nws.

Hyperglycemia, uas feem ntau ua rau nws tus kheej tom qab kev noj ntawm cov carbohydrates, tsis yog txaus ntshai tom qab kev siv gliclazide. Platelet sib sau ua ke, fiblinolytic thiab heparin kev ua si nce nrog rau cov tshuaj.

Kev ua kom siab ntxiv rau heparin, muaj tshuaj thiab tshuaj muaj zog tiv thaiv kab mob.

Lub tshuab ua haujlwm ntawm metformin, qhov pib thib ob uas tseem ceeb ntawm Glimecomb, yog ua raws li qhov txo qis hauv cov piam thaj hauv qab zib vim kev tswj cov glycogen tawm hauv lub siab.

Txhim kho qhov rhiab heev ntawm receptors, cov tshuaj txo qhov tsis kam ntawm cov hlwb rau insulin.

Los ntawm kev txwv cov khoom tsim cov piam thaj los ntawm cov protein thiab cov rog, nws nce nws txoj kev thauj mus los rau cov leeg nqaij kom nquag noj.

Hauv cov hnyuv, metformin inhibits qhov nqus ntawm cov piam thaj los ntawm phab ntsa. Cov ntshav sib xyaw ua kom zoo dua: qhov kev sib txuam ntawm cov roj (cholesterol) tag nrho, triglycerol thiab LDL (cov "roj" cholesterol) tsawg dua, cov roj HDL ("zoo") nce siab. Metformin tsis cuam tshuam rau β-hlwb lub luag haujlwm rau kev tsim lawv tus kheej cov insulin. Ntawm no sab, cov txheej txheem tswj hwm gliclazide.

Leej twg tsis haum Glimecomb

Cov tshuaj ua ke tsis tau sau tseg:

Tus mob ntshav qab zib hom 1,
Nrog ketoacidosis (mob ntshav qab zib),
Nrog rau cov kab mob ntshav qab zib ua rau mob taub hau thiab coma,
Cov neeg mob uas muaj lub raum khiav tsis zoo ua tsis tau haujlwm
Nrog rau hypoglycemia,
Yog tias muaj mob hnyav (mob, qhuav dej, poob siab) tuaj yeem ua rau lub raum lossis lub siab ua haujlwm tsis zoo,
Thaum pathologies nrog cov pa oxygen tshaib plab ntawm cov ntaub so ntswg (lub plawv nres, mob plawv lossis ua pa tsis ua haujlwm),
Cov poj niam cev xeeb tub thiab lactating
Nrog rau thaum uas tig mus siv cov miconazole,
Hauv cov xwm txheej uas cuam tshuam nrog kev hloov cov ntsiav tshuaj ib ntus nrog insulin (kis, khiav haujlwm, raug mob hnyav),
Nrog lub hypocaloric (txog 1000 kcal / hnub) kev noj haus,
Rau cov neeg quav cawv nrog quav dej cawv,
Yog tias koj muaj keeb kwm ntawm cov kab mob lactic acidosis,
Nrog hypersensitivity rau cov tshuaj ntawm cov tshuaj qauv ntawm cov tshuaj.