Lozap lossis Lorista

Yam tshuaj twg zoo dua: Lozap lossis Lorista? Ob qho tshuaj yeeb tshuaj no muaj kev pom dav dav, tab sis lawv lub hom phiaj tseem ceeb yog txo cov ntshav siab. Txheeb xyuas qhov sib txawv ntawm cov tshuaj thiab txiav txim seb qhov twg zoo dua rau kev kho mob ntshav siab, koj yuav tsum cais cov lus qhia rau Lozapa thiab Lorista, ntxiv rau sab laj nrog tus kws tshaj lij rau xaiv ib qho zuj zus thiab tsim lub sijhawm.

TSEEM CEEB YUAV TSUM! Tabakov O .: "Kuv tuaj yeem pom zoo tsuas yog ib txoj kev kho kom sai ntawm kev ceev siab" nyeem rau.

Kev sib xyaw thiab kev ua

Tshuaj tshuaj “Lorista” thiab “Lozap” muaj cov tshuaj losartan uas yog ib yam muaj tshuaj lom. Ntu Cheebtsam "Lorista":

• hmoov txhuv nplej siab
• zaub mov additive E572,
• fiber ntau
• cellulose
• kev muab zaub mov ntxiv E551.

Cov tshuaj ntxiv hauv cov khoom lag luam tshuaj "Lozap" muaj raws li nram no:

• hypromellose,
• croscarmellose sodium,
• MCC
• povidone
• zaub mov additive E572,
• mannitol.

Qhov kev ua haujlwm ntawm Lozap kho mob yog ua rau txo cov ntshav siab, qhov kev tawm tsam ntawm cov leeg ntshav feem ntau, txo cov ntshav ntawm lub siab, thiab tshem tawm cov dej ntau dhau thiab tso zis tawm ntawm lub cev nrog zis. Cov tshuaj yog tiv thaiv myocardial hypertrophy thiab nce kev ua kom lub cev muaj zog hauv cov neeg muaj mob tsis ua haujlwm ntev ntawm lub siab nqaij. Lorista thaiv AT II cov neeg tau txais hauv lub raum, lub plawv, thiab cov hlab ntsha, uas pab txo qis ntawm cov hlab ntshav lumen, qis OPSS, thiab, yog li, txo qis ntshav siab tso tawm.

Kev taw qhia thiab contraindications

Npaj raws li losartan raug pom zoo rau siv rau hauv cov xwm txheej hauv qab no:

Nws yog contraindicated yuav siv cov tshuaj npaj muaj tib yam tshuaj losartan rau cov poj niam hauv txoj hauj lwm ntawm cov niam laus, hauv cov menyuam hnub nyoog qis dua 18 xyoo, nrog rau cov kab hauv qab no:

• ntshav siab
• theem siab ntawm cov poov tshuaj nyob rau hauv cov ntshav,
• lub cev qhuav dej
• tus neeg tsis qaug rau yeeb tshuaj,
• lactose thev tsis tau.

Lwm cov duab tawm

Yog tias muaj qee yam nws tsis tuaj yeem siv "Lozap" thiab "Lorista", cov kws kho mob tau sau lawv cov analogues:

• Brozaar
• Karzartan
• Lakea
• Blocktran
• "Lozarel"
• Tubkawm Presartan
• Zisakar
• Losacor
• Vazotens
• "Renicard"
• Cozaar
• "Lotor".

Txhua yam tshuaj, uas yog ib qho piv txwv ntawm Lorista thiab Lozapa, nws muaj nws cov lus qhia rau kev siv, uas txhais tau tias nws yuav tsum tau noj tsuas yog tom qab sab laj nrog tus kws kho mob profile uas tau sau ntawv kho mob ib leeg rau txhua tus neeg mob. Nrog rau kev siv tshuaj rau tus kheej, kev pheej hmoo ntawm kev mob tshwm sim rau cov kev mob tshwm sim ntau ntxiv.

Cov yam ntxwv dav dav

Ob qho tshuaj yeeb tshuaj yog raws li losartan, uas provokes siab selectivity - qhov cuam tshuam ntawm hom pom ntawm cov kis tau txais meej meej, tsis muaj kev cuam tshuam rau lwm lub cev ua haujlwm, uas ua rau muaj kev nyab xeeb zoo dua. Muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj, uas provokes ib qho yooj yim kev txais tos cov txheej txheem. Cov khoom siv ua kom lub zog tsis cuam tshuam rau cov metabolism ntawm carbohydrates thiab lipids, uas ua rau nws siv tau cov tshuaj txawm tias muaj ntshav qab zib. Ob qho tshuaj no tsis siv rau hauv kev kho mob me nyuam yaus.

Qhov txawv ntawv yog dab tsi?

Lozap raws li ib feem ntawm cov khoom xyaw ntxiv tsis muaj cov lactose, uas ua rau muaj peev xwm siv nws qhov teeb meem ntawm kev siv tsis txaus rau cov khoom siv no.

Lorista muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj, tab sis nrog cov tshuaj sib txawv (nrog cov sib txawv ntawm cov tshuaj nquag), uas tso cai rau koj kom xaiv qhov zoo tshaj rau cov tshuaj rau qhov no lossis cov kabmob ntawd.

Yog hais tias tus neeg mob tau mob tsis txaus lactose, ces Lozap yog tus kho mob. Hauv lwm qhov xwm txheej, tus kws kho mob tuaj yeem sau ib qho lossis lwm yam tshuaj, txij li lawv zoo ib yam hauv kev muaj pes tsawg leeg thiab teeb tsa cov txheej txheem sib kis. Nws yog tshuaj rau ntshav siab, raws li kev tiv thaiv ntawm kev tshwm sim ntawm pathologies ntawm lub plawv, nrog rau cov hlab ntsha, hauv cov kab mob mus ntev ntawm lub plawv tsis ua haujlwm, nrog rau cov xwm txheej ntawm kev puas tsuaj rau lub raum hlab ntsha (hauv ntshav qab zib).

Feem ntau, cov neeg mob qhia tias Loriste yog qhov zoo dua vim tias ntau yam tshuaj ntau dhau ntawm cov tshuaj nquag nyob hauv cov ntsiav tshuaj, uas ua rau noj cov tshuaj tau yooj yim dua. Tab sis nws yuav tsum tau yug los hauv lub siab tias cov tshuaj no muaj cov nqi siab dua. Nws yog tshuaj rau cov hlab ntsha txhaws, ua ib qho kev tiv thaiv kev tiv thaiv mob stroke, nyob rau hauv rooj plaub ntawm mob plawv tsis ua haujlwm.

Cov yam ntxwv ntawm Lozap

Cov tshuaj muaj cov cwj pwm hauv qab no:

1. Kev Sib Sau thiab daim ntawv ntawm kev tso tawm. Lozap yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated nrog soluble zaj duab xis ntawm cov xim dawb los yog daj thiab lub ntsej muag kheej kheej. Cov tshuaj muaj pes tsawg leeg xws li 12,5 lossis 50 mg ntawm potassium losartan, crystalline cellulose, mannitol, silicon dioxide, magnesium stearate, hypromellose, macrogol. Cov ntsiav tshuaj tau ntim rau hauv cov hlwv ntawm 10 pcs. Cov thawv ntawv thawv muaj 3, 6 lossis 9 contour.
2. Pharmacological kev txiav txim. Cov tshuaj txo qhov rhiab ntawm angiotensin receptors yam tsis muaj kev cuam tshuam kev ua haujlwm kininase. Tawm tsam keeb kwm yav dhau los ntawm kev noj Lozap, kev tawm tsam ntawm peripheral hlab ntsha, theem ntawm adrenaline nyob rau hauv cov ntshav thiab ntshav siab hauv cov hlab ntsws tsawg. Cov poov tshuaj losartan muaj cov nyhuv tshuaj tsis haum. Qhov muaj txiaj ntsig zoo ntawm cov tshuaj ntawm cov hlab plawv yog tshwm sim hauv kev tiv thaiv ntawm cov leeg mob plawv thiab kev txhim kho hauv lub neej zoo ntawm cov neeg mob uas muaj mob plawv.
3. Cov Tshuaj Pharmacokinetics Cov tshuaj ua si nquag nkag rau hauv cov ntshav, thaum nws dhau los ntawm daim siab, nws hloov mus rau hauv ib qho kev zom zaub mov. Qhov siab tshaj plaws ntawm losartan thiab nws cov khoom lag luam hauv plasma hauv plasma raug txiav txim siab 60 feeb tom qab kev tswj hwm. 99% ntawm cov feem cuam koom nrog khi rau cov ntshav protein. Cov khoom tsis hla cov ntshav-lub nplov teeb meem. Losartan thiab nws cov metabolites yog cov tawm hauv cov zis.
4. Feem ntawm daim ntawv thov. Cov tshuaj yog siv los ua ib feem ntawm txoj kev kho mob rau txoj kev mob ntshav siab thiab mob plawv tsis ua haujlwm ntev. Cov tshuaj yuav pab txo qis kev pheej hmoo ntawm kev tsim kev phom sij ntawm kev mob ntshav siab thiab kev loj hlob ntawm cov leeg ntshis. Nws yog qhov ua tau los siv Lozap rau mob ntshav qab zib nephropathy, nrog rau kev nce qib ntawm creatinine thiab protein ntau hauv cov zis.
5. Cov Yuav Tsum Muaj Cov tshuaj tsis siv thaum cev xeeb tub, lactation thiab ib tus neeg tsis kam txais rau cov khoom siv. Qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj antihypertensive rau cov menyuam yaus tseem tsis tau txhim kho. Nrog kev ceev faj, Lozap yog siv rau kev mob ntshav hauv lub plawv, qhov kev txo qis hauv cov ntshav ntawm cov ntshav, ua txhaum ntawm cov dej-ntsev tshuav, qhov nqaim ntawm cov hlab ntsha hauv lub plawv, thiab lub siab ua haujlwm tsis zoo.
6. Txoj kev ntawm daim ntawv thov. Cov ntsiav tshuaj tau siv tsis hais noj mov 1 zaug hauv ib hnub. Cov koob tshuaj yog txiav txim siab los ntawm hom thiab qhov tseeb ntawm cov chav kawm ntawm tus kab mob. Qhov koob tshuaj txhua hnub yog txo qis nrog kev siv Lozap hauv kev txuam nrog diuretics thiab lwm yam tshuaj tiv thaiv kab mob siab. Txoj kev kho mob yuav kav kom txog thaum uas cov ntshav siab tso tas li.
7. Cov teebmeem tsis xav tau. Qhov tsis txaus ntseeg muaj tshwm sim nyob ntawm cov koob tshuaj muab. Cov kev mob puas siab ntsws feem ntau (asthenic syndrome, kev ua kom tsis muaj zog, mob taub hau), mob plab zom mov (raws plab, xeev siab thiab ntuav) thiab hnoos qhuav. Ua xua nyob rau hauv daim ntawv ntawm urticaria, tawv nqaij khaus thiab rhinitis tsis tshua pom muaj.

Cov yam ntxwv Lorista

Lorista muaj cov yam ntxwv li nram no:

1. Daim ntawv tso tawm. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm ntsiav tshuaj, enteric coated nrog ib tug daj xim.
2. Muaj pes tsawg leeg. Txhua lub ntsiav tshuaj muaj 12,5 mg ntawm poov tshuaj losartan, cellulose hmoov, mis qab zib monohydrate, qos hmoov txhuv nplej siab, dehydrated silicon dioxide, calcium stearate.
3. Pharmacological kev txiav txim. Lorista belongs rau cov tshuaj tiv thaiv kev tsis haum ntawm cov pab pawg ntawm nonpeptide angiotensin receptor blockers. Cov tshuaj txo cov kev phom sij txaus ntshai ntawm angiotensin yam 2 ntawm cov hlab ntshav. Thaum noj tshuaj, muaj qhov txo qis ntawm aldosterone synthesis thiab kev hloov ntawm cov hlab ntsha tsis kam. Qhov no tso cai rau Lorista siv los tiv thaiv kev txhim kho ntawm cov hlab plawv thiab lub plawv nres cuam tshuam nrog kev ua haujlwm tsis zoo ntawm lub siab nqaij. Cov tshuaj muaj cov nyhuv ntev heev.
4. Xuas thiab faib khoom. Thaum noj ntawm qhov ncauj, cov tshuaj nquag yuav nqus sai rau hauv cov ntshav. Lub cev kwv yees li 30% ntawm kev muab tshuaj. Hauv daim siab, losartan tau hloov pauv mus ua tus nquag carboxy metabolite. Kev kho mob siab rau ntawm cov tshuaj nquag thiab nws cov khoom lag luam metabolic hauv cov ntshav tau kuaj pom tom qab 3 teev. Qhov kev tshem tawm ib nrab-lub neej ua 6-9 teev. Metabolites ntawm losartan ua rau cov zis thiab tso quav.
5. Kev ntsuas rau siv. Cov tshuaj yog siv los txo cov kev pheej hmoo ntawm kev tuag nyob rau hauv cov neeg mob uas muaj kev mob ntshav siab thiab mob plawv. Lorista tuaj yeem siv los ntawm cov neeg mob ntshav qab zib mellitus uas muaj proteinuria heev.
6. Txwv tsis pub siv. Antihypertensive tus neeg sawv cev tsis tuaj yeem siv thaum cev xeeb tub thiab lactation, kev ua xua rau losartan thiab menyuam yaus (txog 18 xyoo).
7. Txoj kev ntawm daim ntawv thov. Qhov pom zoo kom noj txhua hnub yog 50 mg. Cov tshuaj yuav tshwm sim ib zaug thaum sawv ntxov. Tom qab ua haujlwm ntawm cov ntshav siab, cov koob tshuaj yog txo rau ib koob tshuaj txij nkawm (25 mg rau ib hnub).
8. Sab sij huam. Nruab nrab thiab siab siab ntawm losartan tuaj yeem ua rau txo cov ntshav siab ntau ntxiv, nrog rau kiv taub hau, leeg tsis muaj zog thiab qaug zog. Cov txiaj ntsig tsis zoo ntawm cov tshuaj ntawm cov zom zaub mov yog pom tias zawv plab, xeev siab thiab ntuav, mob hauv plab, nce kev ua haujlwm ntawm daim siab enzymes. Muaj qee zaus, kev tsis haum tshuaj tshwm sim rau txoj kev o ntawm lub ntsej muag thiab larynx.

Kev Sib piv Cov Tshuaj

Thaum muab piv cov yam ntxwv ntawm cov tshuaj tiv thaiv antihypertensive, ob qho tib si ib txwm muaj thiab tshwj xeeb yog qhov qhia tawm.

Qhov zoo sib xws ntawm cov tshuaj muaj nyob rau hauv cov nram qab no zoo:

• ob qho tib si Lozap thiab Lorista tau zwm nrog cov pab pawg ntawm angiotensin receptor blockers,
• tshuaj muaj npe nyob rau tib cov cim qhia txog kev siv,
• ob cov tshuaj yog xyuas losartan,
• cov nyiaj muaj nyob hauv ntsiav tshuaj daim ntawv.

Lub tswv yim ntawm cov kws kho plawv

Svetlana, 45 xyoo, Yekaterinburg, kws kho plawv: “Lozap thiab nws lub hlwb Lorista tau zoo tsim hauv kev kho plawv. Lawv tau siv los kho thawj qhov kev mob ntshav siab. Kev noj tshuaj pab tau sai sai tiv thaiv cov ntshav siab. 1 zaug ib hnub. Cov kev mob tshwm sim tsis tshua muaj heev. "

Elena, hnub nyoog 34 xyoo, Novosibirsk, kws kho plawv: "Lorista thiab Lozap yog cov neeg ua haujlwm siab siab uas ua rau muaj qhov mob me ntsis. Lawv txo tus ntshav siab tsis ua rau kev txhim kho orthostatic tsis muaj zog. pab kom tshem tawm cov kua dej ntau dhau tsis muaj kev cuam tshuam cov dej-ntsev sib npaug. Lorista muaj lactose, yog li rau lactase deficiency, Lozap yuav tsum tau nyiam. "

Tus neeg mob tshuaj xyuas txog Lozap thiab Lorista

Eugenia, 38 xyoo, Barnaul: "Tawm tsam keeb kwm ntawm kev ntxhov siab, ntshav siab nce ntxiv. Tus kws kho mob tau qhia Lozap. Kuv noj cov ntsiav tshuaj thaum sawv ntxov, uas tiv thaiv kev mob taub hau thiab lwm cov tsos mob tsis zoo ntawm kub siab. Cov tshuaj kuj muaj cov tshuaj zoo dua - Lorista. Kuv sim cov tshuaj no txawm li cas los xij, lawv tau muaj pov thawj tsawg dua. "

Lozap Cov Khoom

Daim ntawv tso tawm - ntsiav tshuaj. Cov tshuaj yuav tuaj yeem yuav hauv chaw muag tshuaj ntawm 30, 60 thiab 90 daim ib pob. Lub hauv paus tseem ceeb nyob rau hauv lawv yog losartan. 1 lub ntsiav tshuaj tuaj yeem ntim 12,5, 50 thiab 100 mg. Ntxiv rau, muaj cov pabcuam kev sib txuas.

Cov kev npaj ua Lozap thiab Lorista yog cov qauv ua piv txwv thiab koom rau tib pab pawg neeg muag tshuaj - angiotensin 2 receptor antagonists.

Cov nyhuv ntawm cov tshuaj Lozap yog tsom rau txo cov ntshav siab. Tsis tas li ntawd, cov tshuaj txo qis tag nrho kev tawm tsam. Ua tsaug rau cov twj, qhov thauj khoom ntawm lub plawv mob siab kuj txo. Qhov ntau thiab tsawg ntawm cov dej thiab ntsev yog tawm hauv lub cev nrog rau cov zis.

Lozap txwv tsis pub muaj kev cuam tshuam nyob rau hauv kev ua haujlwm ntawm myocardium, nws cov hypertrophy, tsub kom lub siab ntev ntawm lub plawv thiab cov hlab ntsha mus rau kev ua haujlwm hauv lub cev, tshwj xeeb tshaj yog nyob rau cov neeg muaj mob pathologies ntawm hom no.

Ib nrab-lub neej ntawm cov lus nquag yog txij li 6 txog 9 teev. Kwv yees li 60% ntawm cov metabolite nquag tso nrog bile, thiab tus so nrog tso zis.

Cov lus qhia rau kev siv Lozap muaj raws li hauv qab no:

• leeg ntshav siab
• mob plawv tsis ua hauj lwm
• cov teeb meem ntawm hom 2 mob ntshav qab zib mellitus (nephropathy vim hypercreatininemia thiab proteinuria).

Tsis tas li, cov tshuaj tau raug txo los txo txoj kev pheej hmoo ntawm kev txhim kho cov hlab plawv pathologies (siv rau kev mob hlab ntsha tawg), ntxiv rau txo qis kev tuag ntawm cov neeg muaj ntshav siab thiab lub plawv tawg.

Lozap txwv tsis pub muaj kev cuam tshuam nyob rau hauv kev ua haujlwm ntawm myocardium, nws hypertrophy, nce endurance ntawm lub siab.
Rau cov menyuam yaus hnub nyoog qis dua 18 xyoo, cov tshuaj tseem tsis haum.
Cev xeeb tub thiab lactation yog contraindications rau kev siv Lozap.
Cov nyhuv ntawm cov tshuaj Lozap yog tsom rau txo cov ntshav siab.
Daim ntawv tso tawm ntawm Lozap yog cov ntsiav tshuaj.

Cov Lus Cog Tseg rau kev siv Lozap yog:

• cev xeeb tub thiab lactation,
• hypersensitivity rau cov tshuaj thiab nws cov khoom siv.

Cov me nyuam qis dua 18 xyoo kuj tsis haum.

Ceev faj koj yuav tsum tau noj cov tshuaj no rau cov neeg tsis muaj dej-ntsev kom tshuav nyiaj li cas, muaj ntshav siab, ntshav tsis txaus hauv raum, mob siab lossis raum tsis ua haujlwm.

Yuav ua li cas Lorista ua hauj lwm?

Daim ntawv tso tawm ntawm cov tshuaj Lorista yog ntsiav tshuaj. 1 pob muaj 14, 30, 60 lossis 90 daim. Lub hauv paus nquag khoom siv yog losartan. 1 ntsiav tshuaj muaj 12,5, 25, 50, 100 thiab 150 mg.

Qhov kev txiav txim ntawm Lorista yog tsom kom thaiv AT 2 receptors hauv plawv, leeg tshav thiab lub raum. Vim qhov no, lumen ntawm cov hlab ntsha, lawv cov kuj tsis kam, tus nqi ntawm cov ntshav siab poob qis.

Kev ntsuas rau kev siv muaj raws li nram no:

• ntshav siab
• txo qhov kev pheej hmoo ntawm mob hlab ntsha tawg nrog tawg thiab myocardial deformities,
• mob plawv tsis ua hauj lwm
• kev tiv thaiv ntawm cov teeb meem cuam tshuam rau lub raum hauv hom 2 mob ntshav qab zib mellitus nrog ntxiv proteinuria.

Lorista tau sau tseg kom tiv thaiv cov teeb meem cuam tshuam rau lub raum hauv hom 2 mob ntshav qab zib mellitus nrog cov proteinuria ntxiv.
Kev ua ntawm Lorista yog tswj kom txo qis ntshav siab.
Cov tshuaj yog kws kho mob txhawm rau txo cov kev pheej hmoo ntawm mob stroke nrog tawg thiab myocardial deformities.Daim ntawv tso tawm ntawm cov tshuaj Lorista yog ntsiav tshuaj.

Contraindications suav nrog:

• ntshav siab
• lub cev qhuav dej
• ntxhov siab dej-ntsev tshuav,
• lactose intolerance,
• ua txhaum ntawm cov txheej txheem nqus cov piam thaj,
• cev xeeb tub thiab lactation.
• hypersensitivity rau cov tshuaj los yog nws lub Cheebtsam.

Rau cov menyuam hnub nyoog qis dua 18 xyoo, Cov tshuaj tseem tsis tau pom zoo. Ceev faj yuav tsum tau muab rau cov neeg muaj mob raum thiab mob siab tsis txaus, tawv ncauj ntawm cov hlab ntsha hauv ob lub raum.

Sib piv ntawm Lozap thiab Lorista

Txhawm rau txiav txim siab seb qhov tshuaj twg - Lozap lossis Lorista - zoo dua rau tus neeg mob, nws yog qhov tsim nyog los txiav txim siab lawv cov zoo sib xws thiab seb cov tshuaj sib txawv li cas.

Lozap thiab Lorista muaj ntau yam zoo sib xws, li Lawv yog cov analogues:

• ob qho tshuaj noj ua ke rau cov pab pawg ntawm angiotensin 2 receptor antagonists,
• muaj tib yam qhia rau siv,
• muaj cov nquag nquag sib xyaw ua ke - losartan,
• ob qho kev xaiv muaj nyob rau hauv cov ntsiav tshuaj daim ntawv.

Raws li rau kev noj tshuaj txhua hnub, ces 50 mg rau ib hnub yog qhov txaus. Txoj cai no zoo ib yam rau Lozap thiab Lorista, raws li kev npaj muaj tib tus nqi ntawm losartan. Ob qho tshuaj yuav tuaj yeem yuav hauv khw muag tshuaj tsuas yog los ntawm kws kho mob sau ntawv tuaj.

Lozap thiab Lorista tuaj yeem ua teeb meem pw tsaug zog.
Mob taub hau, kiv taub hau - kuj yog ib qho kev phiv tshuaj.
Thaum noj Lorista thiab Lozap, arrhythmia thiab tachycardia yuav tshwm sim.
Mob plab, xeev siab, mob plab, mob plab zom mov yog phiv los ntawm cov tshuaj.

Cov tshuaj noj tau zoo, tab sis qee zaum qee qhov tsos mob tsis tuaj yeem tshwm sim. Cov kev mob tshwm sim ntawm Lozap thiab Lorista kuj zoo ib yam:

• teeb meem pw tsaug zog
• mob taub hau, kiv taub hau,
• tas li nkees
• arrhythmia thiab tachycardia,
• mob plab, xeev siab, mob plab, mob plab zom mov,
• congestion, o ntawm cov nqaij mos hauv cov ntswg hauv qhov ntswg,
• hnoos, mob ntsws, pharyngitis.

Ib qho ntxiv, nws yuav tsum tau yug los hauv lub siab tias kev npaj ua ke kuj tseem muaj - Lorista N thiab Lozap Plus. Ob qho tshuaj muaj tsis tsuas yog losartan ua cov tshuaj lom, tab sis kuj tseem muaj lwm qhov sib xyaw - hydrochlorothiazide. Lub xub ntiag ntawm xws li cov pabcuam pabcuam hauv kev npaj yog qhia los ntawm lub npe. Rau Lorista, qhov no yog N, ND lossis H100, thiab rau Lozap, lo lus "ntxiv".

Lozap Plus thiab Lorista N yog cov qauv zoo sib xws. Ob qho tshuaj muaj 50 mg ntawm losartan thiab 12.5 mg ntawm hydrochlorothiazide.

Kev npaj rau hom xyaw ua ke yog tsim los tswj hwm sai li sai 2 txheej txheem cuam tshuam txog ntshav nce. Losartan qis cov leeg vascular, thiab hydrochlorothiazide yog tsim los tshem tawm cov kua qog tawm hauv lub cev.

Cov yam ntxwv ntawm kev kho kub siab nrog rau cov tshuaj LozapLorista - ib qho yeeb tshuaj kom txo qis ntshav siab Lozap ntxiv rau cov lus qhia

Dab tsi yog qhov txawv?

Qhov sib txawv ntawm Lozap thiab Lorista yog qhov tsis tseem ceeb:

• ntau npaum (Lozap tsuas muaj 3 txoj kev xaiv, thiab Lorista muaj ntau txoj kev xaiv - 5),
• cov neeg tsim khoom (Lorista yog tsim los ntawm lub tuam txhab Slovenian, txawm hais tias muaj cov ceg Lavxias - KRKA-RUS, thiab Lozap yog tsim los ntawm lub koom haum Slovak Zentiva).

Txawm hais tias siv tib yam tseem ceeb sib xyaw ua ke, cov npe ntawm cov tsis muaj npe kuj yog qhov sib txawv. Cov khoom siv hauv qab no yog siv:

1. Cellactose Tam sim no tsuas yog hauv Lorist. Qhov sib xyaw no tau los ntawm kev lactose monohydrate thiab cellulose. Tab sis tom kawg kuj tseem muaj nyob hauv Lozap.
2. Hmoov txhuv nplej siab. Tsuas muaj nyob hauv Lorist xwb. Ntxiv mus, muaj 2 ntau hom nyob hauv tib cov tshuaj - gelatinized thiab pob kws hmoov txhuv nplej siab.
3. Crospovidone thiab mannitol. Muaj nyob hauv Lozap, tab sis tsis tuaj nyob hauv Lorist.

Txhua lwm yam zam rau Lorista thiab Lozap yog tib yam.

Dab tsi yog qhov zoo dua li Lozap lossis Lorista

Ob qho tshuaj puav leej muaj txiaj ntsig hauv lawv pawg. Cov tshuaj ntawm losartan muaj cov zoo li nram no:

1. Xaiv Xaiv. Cov tshuaj yog tsom rau kev khi tsuas yog nrog cov tsim nyog txais. Vim tias qhov no, nws tsis cuam tshuam rau lwm qhov hauv lub cev. Vim tias qhov no, ob qho tshuaj suav pom tias muaj kev nyab xeeb dua lwm cov tshuaj.
2. Kev ua haujlwm siab thaum noj cov tshuaj hauv qhov ncauj.
3. Tsis muaj kev cuam tshuam dab tsi rau cov txheej txheem metabolic ntawm cov rog thiab carbohydrates, yog li ob qho tshuaj tso cai rau hauv ntshav qab zib.

Losartan suav hais tias yog ib qho ntawm thawj cov tshuaj los ntawm cov pab pawg ntawm blockers, uas tau pom zoo rau kev kho mob tawg nyob rau hauv 90s. Txog tam sim no, cov tshuaj raws nws siv rau kev mob ntshav siab.

Ob lub Lorista thiab Lozap yog cov tshuaj siv tau zoo vim yog lub zog ntawm losartan hauv kev xav zoo ib yam. Tab sis thaum xaiv cov tshuaj, contraindications tseem tau rau hauv tus account.

Lorista suav hais tias yog me ntsis phom sij rau tib neeg dua li Lozap. Qhov no yog vim qhov tseeb tias cov kev mob tshwm sim feem ntau tshwm sim. Tsis tas li ntawd, cov tshuaj zoo li no yog txwv rau cov neeg uas tsis haum lactose thiab ua xua rau hmoov txhuv nplej siab. Tab sis tib lub sij hawm, xws li cov tshuaj muaj qhov pheej yig dua.

Lorista suav hais tias yog me ntsis phom sij rau tib neeg dua li Lozap.

Kev txheeb xyuas los ntawm cov kws kho plawv txog Lozap lossis Lorista

Danilov SG: "Ntau xyoo dhau los ntawm kev xyaum, cov tshuaj Lorista tau ua pov thawj nws tus kheej. Nws yog qhov pheej yig, tab sis cov cuab yeej siv tau zoo. Nws pab daws kev kub siab. Cov tshuaj yooj yim rau noj, muaj tsawg phiv, thiab lawv tsis tshua tshwm sim."

Zhikhareva EL: "Lozap yog yeeb tshuaj rau kev kho ntshav siab. Nws muaj cov nyhuv me, yog li lub siab tsis poob ntau. Muaj ob peb cov kev mob tshwm sim."

Pharmacological kev txiav txim

Cov tshuaj antihypertensive. Tshwj xeeb angiotensin II receptor antagonist (subtype AT1). Nws tsis inhibit kininase II, ib qho enzyme uas catalyzes hloov dua siab tshiab ntawm angiotensin I rau angiotensin II. Txo OPSS, ntshav concentration ntawm adrenaline thiab aldosterone, ntshav siab, ntshav siab hauv cov ntsws ntsig, txo qis tom qab, muaj cov nyhuv diuretic. Nws cuam tshuam nrog kev txhim kho myocardial hypertrophy, ua rau lub cev muaj zog ntau dua nyob rau hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev. Losartan tsis inhibit ACE kininase II thiab, raws li, tsis tiv thaiv kev puas tsuaj ntawm bradykinin, yog li ntawd cov kev mob tshwm sim cuam tshuam nrog bradykinin (piv txwv li, angioedema) muaj tsawg heev.

Hauv cov neeg mob uas mob ntshav tsis tawm ntshav tsis muaj concomitant mob ntshav qab zib mellitus nrog proteinuria (ntau dua 2 g / hnub), kev siv cov tshuaj txo cov proteinuria ntau, kev tsis haum ntawm albumin thiab immunoglobulins G.

Stabilizes qib ntawm urea hauv ntshav ntshav. Nws tsis muaj dab tsi cuam tshuam rau cov zaub tsis zoo ntawm lub cev thiab tsis muaj qhov cuam tshuam lub sijhawm ntev ntawm kev saib xyuas ntawm norepinephrine hauv cov ntshav ntshav. Losartan ntawm txoj kev noj tshuaj kom txog li 150 mg ib hnub twg tsis cuam tshuam txog theem ntawm triglycerides, tag nrho cov roj (cholesterol) thiab HDL cholesterol hauv cov ntshav ntshav hauv cov neeg mob ntshav siab. Nyob rau tib lub sijhawm, losartan tsis cuam tshuam rau yoo ntshav cov ntshav.

Tom qab ib qho kev tswj hwm ntawm qhov ncauj, qhov kev tiv thaiv hypotensive (systolic thiab diastolic ntshav siab) nce mus txog qhov siab tshaj plaws tom qab 6 teev, tom qab ntawd maj mam txo qis hauv 24 teev.

Qhov siab tshaj plaws kev kho mob tshwm sim 3-6 lub lis piam tom qab pib siv tshuaj.

Cov Tshuaj Pharmacokinetics

Thaum noj, losartan yog qhov zoo nqus, thiab nws hla cov metabolism hauv "thawj txoj kab" los ntawm lub siab los ntawm carboxylation nrog kev koom tes ntawm cytochrome CYP2C9 isoenzyme nrog kev tsim cov nquag metabolite. Txheej txheem ntawm cov neeg nruab nrog cev ntawm losartan yog li ntawm 33%. Cmax ntawm losartan thiab nws cov tshuaj tiv thaiv metabolite tiav hauv cov ntshav cov ntshav tom qab kwv yees li 1 teev thiab 3-4 teev tom qab noj, feem. Noj tsis txhob cuam tshuam rau lub bioavailability ntawm losartan.

Ntau tshaj li 99% ntawm losartan thiab nws cov nquag metabolite khi rau cov ntshav muaj protein ntau, feem ntau yog nrog albumin. Vd losartan - 34 l. Losartan suab tsis nkag ntawm BBB.

Kwv yees li 14% ntawm losartan muab tso rau qhov ncauj lossis qhov ncauj tau hloov mus rau hauv ib qho tshuaj metabolite.

Lub plasma tshem ntawm losartan yog 600 ml / min, thiab cov nquag metabolite yog 50 ml / min. Lub raum tshem tawm ntawm losartan thiab nws cov metabolite yog 74 ml / min thiab 26 ml / min, feem. Thaum noj, kwv yees li 4% ntawm cov koob tshuaj noj tau tso tawm los ntawm lub raum tsis hloov pauv thiab kwv yees li 6% yog tawm los ntawm lub raum hauv daim ntawv ntawm cov tshuaj tiv thaiv metabolite. Losartan thiab nws cov tshuaj tiv thaiv kab mob nquag tau tshaj tawm yog cov tshuaj kws kho mob cov tshuaj thaum noj ntawm qhov ncauj li 200 mg.

Tom qab lub qhov ncauj tswj hwm, cov ntshav plasma ntau ntawm losartan thiab nws lub zog metabolite txo qis tshaj qhov kawg T1 / 2 ntawm losartan txog 2 teev, thiab cov nquag metabolite txog 6-9 teev. Thaum noj cov tshuaj ntawm 100 mg /, los yog ob losartan lossis lub zog metabolite tseem ceeb hauv ntshav ntshav. Losartan thiab nws cov metabolites yog tawm ntawm cov hnyuv thiab lub raum. Hauv cov neeg tuaj yeem noj qab haus huv, tom qab noj 14C nrog isotope ntawm cov ntawv loartan, li ntawm 35% ntawm lub xov tooj cua tau muaj nyob hauv cov zis thiab 58% hauv cov quav.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Hauv cov neeg mob uas mob sib khuav xws li cawv me ntsis txog rau kev haus dej cawv, lub siab ntawm losartan yog 5 zaug, thiab cov nquag metabolite yog 1.7 npaug ntau dua li cov txiv neej ua haujlwm pab dawb.

Nrog creatinine tshem tawm ntau dua 10 ml / min, qhov kev tso tshuaj ntawm losartan hauv cov ntshav tsis txawv ntawm qhov ntawd nrog lub raum kev ua haujlwm. Hauv cov neeg mob uas xav tau hemodialysis, AUC yog kwv yees li 2 npaug dua rau cov neeg mob uas lub raum tsis ua haujlwm.

Tsis yog losartan thiab nws lub zog metabolite tau tshem tawm ntawm lub cev los ntawm hemodialysis.

Qhov ntau ntawm losartan thiab nws cov metabolite hauv ntshav plasma hauv cov txiv neej laus uas mob ntshav tsis txawv ntau qhov tsis tseem ceeb ntawm cov txiaj ntsig ntawm cov txwv no hauv cov txiv neej hluas nrog kev mob ntshav siab.

Lub plasma cov ntsiab lus ntawm losartan nyob rau hauv cov poj niam uas mob arterial tawg yog 2 npaug ntau dua qhov tseem ceeb nyob rau hauv cov txiv neej nrog mob ntshav siab. Kev xav ntawm lub cev zom zaub mov nquag hauv txiv neej thiab poj niam tsis txawv. Qhov sib txawv ntawm pharmacokinetic no tsis yog qhov tseem ceeb hauv tsev kho mob.

Kev qhia rau kev siv tshuaj LOZAP®

• leeg ntshav siab
• mob plawv tsis ua hauj lwm (raws li ib feem ntawm kev sib txuas ua ke, nrog thev tsis tau lossis qhov tsis muaj txiaj ntsig ntawm kev kho nrog ACE inhibitors),
• txo txoj kev pheej hmoo ntawm kev tsim mob plawv (nrog rau mob stroke) thiab kev tuag ntawm cov neeg mob ntshav siab thiab tawm pob txha tawg ventricular hypertrophy,
• mob ntshav qab zib nephropathy nrog hypercreatininemia thiab proteinuria (piv ntawm cov zis albumin thiab creatinine ntau dua 300 mg / g) hauv cov neeg mob ntshav qab zib hom 2 ntshav qab zib thiab concomitant arterial hypertension (txo qis kev mob ntshav qab zib nephropathy rau lub siab mob raum tsis ua haujlwm).

Tsuas tshuaj thiab tswj hwm

Cov tshuaj tau noj ntawm qhov ncauj, tsis hais noj mov. Tshaj tawm ntawm kev pub nkag - 1 zaug nyob rau ib hnub.

Nrog rau cov hlab ntsha o, qhov nruab nrab txhua hnub koob yog 50 mg. Qee qhov, txhawm kom ua tiav qhov kev kho mob ntau dua, cov tshuaj txhua hnub tuaj yeem nce txog 100 mg hauv 2 lossis 1 koob tshuaj.

Thawj koob tshuaj rau cov neeg mob plawv tsis ua hauj lwm ntev yog 12,5 mg ib hnub ib zaug. Raws li txoj cai, koob tshuaj tau nce nrog lub sijhawm ib asthiv (piv txwv li 12,5 mg rau ib hnub, 25 mg rau ib hnub, 50 mg rau ib hnub) rau ib nrab txij nkawm koob tshuaj ntawm 50 mg 1 zaug nyob rau ib hnub, nyob ntawm seb qhov tiv taus cov tshuaj.

Thaum muab tshuaj rau cov neeg mob uas tau txais cov tshuaj diuretics hauv kev txhaj tshuaj loj, thawj zaug ntawm Lozap® yuav tsum tau txo kom 25 mg ib hnub ib zaug.

Rau cov neeg mob neeg laus, tsis tas yuav kho qhov hloov tshuaj.

Thaum muab tshuaj rau cov tshuaj txhawm rau txo qis kev pheej hmoo ntawm kev txhim kho cov hlab plawv (nrog rau mob stroke) thiab cov neeg tuag nyob hauv cov neeg mob ntshav siab thiab sab laug ventricular hypertrophy, qhov kev pib noj tshuaj yog 50 mg rau ib hnub. Yav tom ntej, cov koob tshuaj hydrochlorothiazide tsawg yuav tau ntxiv thiab / lossis qhov koob tshuaj Lozap® npaj yuav nce ntxiv txog 100 mg rau ib hnub hauv 1-2 koob.

Rau cov neeg mob concomitant yam 2 mob ntshav qab zib mellitus nrog proteinuria, qhov pib ntawm cov tshuaj yog 50 mg ib hnub ib zaug, yav tom ntej, cov koob tshuaj tau nce ntxiv rau 100 mg ib hnub (noj rau hauv qhov kev txiav txim siab ntawm txo ntshav siab) hauv 1-2 koob tshuaj.

Cov neeg mob uas muaj keeb kwm muaj kab mob siab, ua kom lub cev qhuav dej, lub sijhawm mob hemodialysis, nrog rau cov neeg mob uas muaj hnub nyoog tshaj 75 xyoos, raug pom zoo kom txo qis cov tshuaj tiv thaiv qis - 25 mg (1/2 ntsiav tshuaj ntawm 50 mg) ib hnub ib zaug.

Sab sij huam

Thaum siv losartan rau kev kho mob qhov tseem ceeb ntawm kev mob ntshav siab hauv kev tswj hwm kev sib tw, ntawm tag nrho cov kev mob tshwm sim, tsuas yog cov xwm txheej ntawm kiv taub hau sib txawv los ntawm cov placebo los ntawm ntau dua 1% (4.1% tiv thaiv 2.4%).

Koob tshuaj-ua orthostatic muaj cov yam ntxwv ntawm cov neeg tiv thaiv mob, nrog kev siv losartan tau pom hauv tsawg dua 1% ntawm cov neeg mob.

Kev txiav txim siab qhov ntau zaus ntawm cov kev mob tshwm sim: feem ntau (≥ 1/10), feem ntau (> 1/100, ≤ 1/10), qee zaum (≥ 1/1000, ≤ 1/100), tsis tshua muaj (≥ 1/10 000, ≤ 1 / 1000), tsis tshua muaj neeg (≤ 1/10 000, suav nrog ib leeg).

Cov kev mob tshwm sim tshwm sim nrog cov zaus ntau dua 1%:

Cov kev mob tshwm sim ntawm losartan feem ntau yog hloov thiab tsis tas yuav tsum tsis ua ntxiv lawm ntawm cov tshuaj.

Cov kev mob tshwm sim tshwm sim nrog cov zaus tsawg dua 1%

Los ntawm cov hlab plawv system: orthostatic hypotension (koob tshuaj-tiv thaiv), txhaws ntswg, bradycardia, arrhythmias, angina pectoris, vasculitis, myocardial infarction.

Los ntawm cov txheej txheem ua haujlwm: tsis nco qab noj mov, ua qhov ncauj qhuav ntawm lub qhov ncauj, mob hniav, ntuav, ua pa, mob plab, cem quav, mob siab, ua haujlwm rau lub siab ua haujlwm, tsis tshua muaj tshwm sim - muaj txiaj ntsig ntawm AST thiab ALT kev ua si, hyperbilirubinemia.

Kev mob tshwm sim hauv lub cev: tawv nqaij qhuav, erythema, ecchymosis, photosensitivity, nce tawm hws, alopecia.

Ua xua: urticaria, tawm pob ntawm daim tawv nqaij, khaus, angioedema (suav nrog rau ntawm lub suab ntawm lub suab thiab tus nplaig, ua rau txhaws ntawm cov hlab pas thiab / lossis o ntawm lub ntsej muag, daim di ncauj, pharynx).

Los ntawm cov kab mob hemopoietic: qee lub sijhawm - ntshav tsis txaus (ib qho qis me ntsis hauv cov concentration ntawm hemoglobin thiab hematocrit, nruab nrab los ntawm 0.11 g% thiab 0.09 ntim%, feem, tsis tshua muaj - ntawm kev kho mob tseem ceeb), thrombocytopenia, eosinophilia, Shenlein-Genokha purpura.

Los ntawm cov leeg musculoskeletal: arthralgia, mob caj dab, mob nyob rau hauv lub xub pwg, hauv caug, fibromyalgia.

Los ntawm sab hauv nruab nrab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb ntawm lub paj hlwb: ntxhov siab, pw tsaug zog, tsaug zog, nco tsis meej, peripheral neuropathy, mob caj dab, hypesthesia, tshee tshee, ataxia, kev nyuaj siab, tsaus muag, mob taub hau.

Los ntawm cov kab mob hauv nruab siab: tinnitus, saj tsis sib xws, tsis pom kev, pom pob txha.

Los ntawm cov kab mob tso zis: tso zis tseem ceeb, tso zis mob txeeb zig, lub raum khiav tsis zoo, qee zaum - muaj kuab kom ntau thiab tso zis muaj pa nitrogen los yog creatinine ntau ntau nyob rau hauv cov ntshav.

Los ntawm kev yug me nyuam: qis libido, impotence.

Los ntawm ib sab ntawm cov metabolism: feem ntau - hyperkalemia (poov tshuaj theem hauv ntshav ntshav yog ntau tshaj 5.5 mmol / l), gout.

Cov Lus Cog Tseg rau kev siv tshuaj LOZAP®

• cev xeeb tub
• kev pub mis
• hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim tsa),
• ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Nrog kev ceev faj, cov tshuaj yuav tsum raug siv rau kev mob ntshav hauv lub plawv, txo qis hauv bcc, lub cev tsis muaj dej-electrolyte tshuav, ob tog lub raum leeg mob stenosis los yog leeg ntshav ntawm ib lub raum, thiab lub raum / hepatic tsis txaus.

Kev siv LOZAP® thaum lub sijhawm cev xeeb tub thiab lactation

Tsis muaj ntaub ntawv qhia txog kev siv tshuaj Lozap® lub sijhawm cev xeeb tub. Txawm li cas los xij, nws paub tias cov tshuaj uas cuam tshuam ncaj qha rau RAAS, thaum siv nyob rau zaum ob thiab thib peb lub cev xeeb tub, tuaj yeem ua rau muaj kev txhim kho lossis kev tuag ntawm kev loj hlob hauv plab. Yog li, yog tias cev xeeb tub tshwm sim, cov tshuaj yuav tsum tau txiav tam sim ntawd.

Yog tias nws yog qhov yuav tsum tau siv Lozap thaum lactation, yuav tsum txiav txim siab kom tsis txhob pub mis niam, lossis kom tsis txhob kho cov tshuaj.

Cov lus qhia tshwj xeeb

Nws yog qhov tsim nyog los kho lub cev qhuav dej ua ntej sau ntawv rau cov tshuaj Lozap® los yog pib kho nrog kev siv tshuaj nyob rau hauv qis dua.

Cov tshuaj uas cuam tshuam rau RAAS tuaj yeem nce cov ntshav urea thiab ntshiab ntshav creatinine hauv cov neeg mob uas muaj ob leeg lub raum leeg ntshav liab los yog cov raum mob ntshav lub raum.

Hauv cov neeg mob uas muaj lub siab ua mob rau daim siab, cov concentration ntawm losartan hauv cov ntshav plasma nce ntau, thiab yog li ntawd, yog tias muaj keeb kwm muaj kab mob siab, nws yuav tsum yog cov tshuaj txo qis.

Thaum lub sijhawm kev kho mob, cov concentration ntawm cov poov tshuaj nyob rau hauv cov ntshav yuav tsum tau saib xyuas tsis tu ncua, tshwj xeeb tshaj yog nyob rau cov neeg laus, nrog lub raum tsis ua haujlwm.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj tuaj yeem tsim tawm nrog lwm tus neeg sawv cev antihypertensive. Kev sib nrig sib ntxiv ntawm qhov tshwm sim ntawm beta-blockers thiab sympatholytics yog pom. Nrog rau kev siv sib xyaw ua ke ntawm losartan nrog diuretics, ib qho txiaj ntsig zoo raug pom.

Tsis muaj pharmacokinetic cuam tshuam ntawm losartan nrog hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole thiab erythromycin tau sau tseg.

Cov tshuaj Rifampicin thiab fluconazole tau qhia tawm txog kev txo qis cov tshuaj lom metabolite ntawm losartan hauv cov ntshav ntshav. Cov kab mob tseem ceeb ntawm cov kev sib txuam no tseem tsis tau paub.

Ib yam li lwm tus neeg sawv cev uas inhibit angiotensin II los yog nws cov txiaj ntsig, kev siv ua ke ntawm losartan nrog cov tshuaj potassium-sparing diuretics (piv txwv li, spironolactone, triamteren, amiloride), cov tshuaj potassium npaj thiab ntsev uas muaj cov potassium ntxiv rau qhov kev pheej hmoo ntawm hyperkalemia.

NSAIDs, nrog rau xaiv COX-2 inhibitors, tuaj yeem txo cov nyhuv ntawm diuretics thiab lwm cov tshuaj tiv thaiv kev tiv thaiv.

Nrog rau kev siv ua ke ntawm angiotensin II thiab lithium receptor antagonists, nce ntxiv ntawm plasma lithium concentration yog tau. Muab qhov no, nws yog qhov yuav tsum tau hnyav lub txiaj ntsig thiab kev pheej hmoo ntawm kev tswj hwm ntawm losartan nrog lithium ntsev npaj. Yog tias siv kev sib koom ua ke yog qhov tsim nyog, kev saib xyuas ntawm cov roj ntsha lithium hauv cov ntshav ntshav yuav tsum tau soj ntsuam kom tsis tu ncua.