Cov lus qhia rau kev siv tshuaj, tshuaj yeeb dawb, tshuaj xyuas

Cov ntsiav tshuaj-yeeb yaj kiab, 40 mg

Ib ntsiav tshuaj muaj

cov tshuaj heev - atorvastatin calcium 41.44 mg (sib npaug ntawm atorvastatin 40.00 mg)

hauvtus zam: povidone, sodium lauryl sulfate, calcium carbonate, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, crospovidone, magnesium stearate,

plhaub: Opadry Dawb Y-1-7000 (muaj hypromellose, titanium dioxide (E 171) thiab macrogol 400)

Cov ntsiav tshuaj puag ncig ua ke nrog cov xim dawb ua ke txheej, me ntsis convex

Cov chaw muag tshuaj

Atorvastatin nrawm nrawm tom qab kev tswj hwm ntawm qhov ncauj, nws cov ntsiab lus hauv cov ntshav plasma nce mus txog qhov siab kawg tom qab 1-2 teev. Cov neeg kawm ntawv ntawm kev nqus thiab kev nqus ntawm atorvastatin hauv cov ntshav ntshav nce ntxiv hauv kev faib ua feem. Kev txiav txim siab ntawm bioavailability ntawm atorvastatin yog li ntawm 14%, thiab cov kab ke ua haujlwm ntawm lub cev muaj peev xwm tiv thaiv kev ua haujlwm tiv thaiv 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) yog li 30%. Kev siv lub cev tsis tshua muaj txiaj ntsig zoo yog vim muaj cov kab mob presystemic hauv lub plab zom mov ntawm txoj hnyuv thiab / lossis thaum "thawj hla" los ntawm daim siab.

Khoom noj khoom haus me ntsis txo tus nqi thiab kev nqus ntawm kev nqus ntawm cov tshuaj (los ntawm 25% thiab 9%, feem, raws li pom los ntawm cov txiaj ntsig ntawm kev txiav txim siab ntawm Cmax thiab AUC), tab sis qhov txo qis hauv lipoprotein tsawg roj (LDL-C) zoo ib yam li thaum noj atorvastatin ntawm ib plab khoob. Tom qab noj atorvastatin thaum yav tsaus ntuj, nws cov ntshav plasma tsawg dua (Cmax thiab AUC los ntawm 30%) dua li tom qab noj nws thaum sawv ntxov. Txoj kab sib txuas ntawm qhov txheeb ze ntawm qhov nqus ntawm qhov nqus thiab qhov tshuaj ntawm cov tshuaj tau qhia tawm.

Qhov nruab nrab ntim ntawm faib ntawm atorvastatin yog li 381 litres. Kev sib txuas lus nrog plasma protein ntawm tsawg kawg 98%. Qhov erythrocyte / ntshav atorvastatin cov ntsiab lus piv yog 0.25, i.e. atorvastatin tsis txeem cov ntshav liab kom zoo.

Atorvastatin lom zem ntau tsim los ua ortho- thiab para-hydroxylated derivatives thiab ntau cov khoom siv beta oxidation. Ortho- thiab para-hydroxylated metabolites muaj qhov cuam tshuam rau HMG-CoA reductase. Kwv yees li ntawm 70% tsawg dua hauv kev ua haujlwm ntawm HMG-CoA reductase tshwm sim vim qhov kev nqis tes ua ntawm cov roj ntsha nquag mus ua pa. Lub siab cytochrome P450 3A4 ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv atorvastatin: cov tshuaj atorvastatin hauv tib neeg cov ntshav ntshav nce ntxiv thaum noj erythromycin, uas yog qhov tshuaj tiv thaiv ntawm isoenzyme no. Atorvastatin, dhau los, yog qhov tsis muaj zog inhibitor ntawm cytochrome P450 3A4. Atorvastatin tsis muaj qhov teeb meem loj hauv lub tsev kho mob ntawm lub plasma concentration ntawm terfenadine, uas yog metabolized feem ntau los ntawm cytochrome P450 3A4, yog li ntawd, nws tsis zoo li tias atorvastatin muaj cov txiaj ntsig tseem ceeb ntawm pharmacokinetics ntawm lwm qhov chaw ntawm cytochrome P450 3A4.

Atorvastatin thiab nws cov metabolites yog cov tawm nrog cov kua tsib vim los ntawm cov kab mob hepatic thiab / lossis extrahepatic metabolism (atorvastatin tsis ua mob hnyav rau qhov rov ua kom mob loj dua). Ib nrab ntawm lub neej ntawm atorvastatin yog kwv yees li 14 teev. Qhov kev tiv thaiv tiv thaiv HMG-CoA reductase tseem muaj txog 20-30 teev, vim muaj cov metabolites nquag. Tom qab kev tswj hwm ntawm qhov ncauj, tsawg dua 2% ntawm atorvastatin pom nyob hauv zis.

Cov pab pawg neeg tshwj xeeb

Laus: ntshav ntau ntawm atorvastatin nyob rau hauv cov neeg 65 xyoo thiab laus dua yog siab dua (Cmax kwv yees li 40%, AUC los ntawm 30%) dua li cov neeg mob hluas, kev sib txawv ntawm kev nyab xeeb, kev ua tau zoo lossis kev ua tiav ntawm lipid-txo cov hom phiaj kho hauv cov neeg laus piv nrog tag nrho cov pej xeem tsis pom.

Cov menyuam: cov kev tshawb fawb ntawm cov tshuaj pharmacokinetics ntawm cov tshuaj hauv cov menyuam yaus tsis tau ua.

Tub los ntxhais: qhov concentration ntawm atorvastatin nyob rau hauv cov ntshav plasma hauv cov poj niam sib txawv (Cmax los ntawm kwv yees li 20% siab dua, thiab AUC los ntawm 10% qis dua) los ntawm qhov ntawd hauv cov txiv neej, txawm li cas los xij, tsis muaj qhov sib txawv hauv kev kho mob ntawm cov tshuaj ntawm lipid metabolism hauv cov txiv neej thiab poj niam.

Tsis hlauv: kab mob hauv lub raum tsis cuam tshuam qhov kev txiav txim ntawm atorvastatin hauv ntshav ntshav lossis nws cov nyhuv ntawm lipid metabolism, yog li ntawd, cov koob tshuaj hloov pauv rau cov neeg mob uas tsis muaj lub raum tsis ua haujlwm.

Hemodialysis: hemodialysis tsis zoo li yuav ua rau muaj qhov nce ntxiv hauv qhov tshem tawm ntawm atorvastatin, vim tias cov tshuaj muaj feem cuam tshuam nrog cov plasma protein.

Daim siab ua haujlwm: Atorvastatin concentration nce ntau (Cmax txog 16 zaus, AUC txog 11 zaug) hauv cov neeg mob uas muaj cawv ntau ua rau lub siab ua pa (Childe-Pugh B).

Cov Tshuaj Hauv Tshuaj

Atoris® yog cov tshuaj lipid-txo qis cov tshuaj, xaiv sib tw inhibitor ntawm HMG-CoA reductase, cov enzyme tseem ceeb uas hloov 3-hydroxy-3-methylglutaryl-CoA rau mevalonic acid, ua ntej rau cov tshuaj steroids, suav nrog cov roj (cholesterol). Hauv cov neeg mob homozygous thiab heterozygous tsev neeg hypercholesterolemia, cov ntaub ntawv tsis muaj tsev neeg hypercholesterolemia thiab cov roj ntshav sib xyaw ua ke, Atoris® txo qis tag nrho cov roj (Cs), qis lipoprotein roj cholesterol thiab apolipoprotein B thiab roj lipoprotein ntau heev triglycerides, ua rau qhov tsis txaus ntseeg nyob hauv cov roj lipoprotein ntau dua (HDL-C).

Hauv daim siab, triglycerides thiab cov roj (cholesterol) tau nyob hauv qhov sib xyaw ntawm cov lipoproteins tsawg heev (VLDL), nkag mus rau cov ntshav ntshav thiab raug hloov mus rau cov ntaub so ntswg. Cov lipoproteins uas tsis muaj ntau (LDL) yog tsim los ntawm VLDL, uas yog catabolized los ntawm kev sib cuam tshuam nrog kev sib raug zoo siab LDL receptors.

Atoris® txo cov kev sib txuam ntawm cov roj (cholesterol) thiab lipoproteins nyob rau hauv cov ntshav ntshav, tiv thaiv HMG-CoA reductase thiab kev sib xyaw ntawm cov roj cholesterol nyob rau hauv lub siab thiab nce cov "siab" LDL receptors nyob rau ntawm tes, uas ua rau muaj kev nce siab thiab catabolism ntawm LDL cov roj cholesterol.

Kev ntsuas rau siv

- nyob rau hauv kev sib xyaw nrog kev noj haus rau kev kho mob ntawm cov neeg mob uas muaj plasma ntau cov ntsiab lus ntawm cov roj (cholesterol) tag nrho, HDL-C, apolipoprotein B thiab triglycerides, thiab nce HDL-C hauv cov neeg mob ntshav siab (hyperterterolemia) (kab mob heterozygous tsev neeg thiab tsis-tsev neeg hyperchipoleole), sib xyaw (sib xyaw) hyperlipidemia IIa thiab IIb raws li Frederickson), nrog cov ntsiab lus tseem ceeb ntawm triglycerides hauv ntshav ntshav (hom IV raws li Frederickson) thiab cov neeg mob dysbetalipoproteinemia (hom III raws Frederickson), thaum tsis muaj cov txiaj ntsig tsim nyog nrog di oterapii

- txhawm rau txo cov ntshav plasma ntau ntawm cov tag nrho cov roj (cholesterol) thiab LDL-C hauv cov neeg mob homozygous tsev neeg hypercholesterolemia nrog cov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj thiab lwm txoj kev siv tshuaj tsis zoo ntawm kev kho mob.

- txhawm rau txo txoj kev pheej hmoo ntawm kev tuag ntawm kab mob plawv thiab cov kev pheej hmoo ntawm kev tsim cov kab mob myocardial infarction, angina pectoris, mob stroke thiab txo qhov xav tau cov txheej txheem kho mob hauv cov neeg mob plawv thiab / lossis dyslipidemia, zoo li yog tias cov kab mob no tsis pom, tab sis muaj tsawg kawg yog peb muaj kev pheej hmoo rau kev txhim kho mob hlab ntsha plawv, xws li muaj hnub nyoog ntau dua 55 xyoos, haus luam yeeb, mob ntshav siab, ntshav ntau ntawm HDL-C, thiab cov xwm txheej ntawm kev txhim kho mob plawv thaum ntxov hauv cov txheeb ze

- nyob rau hauv kev sib xyaw nrog kev noj haus rau kev kho mob ntawm cov menyuam hnub nyoog 10-17 xyoo nrog cov ntsiab lus plasma ntau dua ntawm cov roj (cholesterol) tag nrho, LDL-C thiab apolipoprotein B nrog heterozygous tsev neeg hypercholesterolemia, yog tias tom qab muaj kev noj zaub mov zoo rau qib LDL-C tseem tshuav> 190 mg / dl lossis qib uas LDL tseem> 160 mg / dl, tab sis muaj qee zaum ntawm kev loj hlob ntawm cov kab mob plawv hauv cov neeg txheeb ze lossis ob lossis ntau dua muaj feem cuam tshuam rau kev mob plawv hauv cov menyuam yaus

Tsuas tshuaj thiab tswj hwm

Ua ntej pib txoj kev kho mob nrog Atoris®, koj yuav tsum sim ua kom tiav kev tswj hwm ntawm hypercholesterolemia los ntawm kev noj haus, kev tawm dag zog thiab kev poob phaus hauv cov neeg mob rog, nrog rau kev kho mob ntawm lwm tus kab mob. Thaum muab tshuaj rau, cov neeg mob yuav tsum pom zoo rau kev noj zaub mov hypocholesterolemic noj, uas nws yuav tsum tau ua raws thaum lub sijhawm kho.

Cov tshuaj yog npaum li cas nyob rau txhua lub sijhawm ntawm hnub, tsis hais noj zaub mov noj. Qhov ntau npaum li cas ntawm cov tshuaj nws txawv ntawm 10 txog 80 mg ib hnub ib zaug, xaiv nws coj mus rau hauv tus account thawj cov ntsiab lus ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ib tus zuj zus. Thaum pib ntawm kev kho mob thiab / lossis thaum lub sijhawm nce ntxiv ntawm Atoris®, nws yog qhov yuav tsum tau soj ntsuam cov lipid cov ntsiab lus hauv cov ntshav ntshav txhua 2-4 lub lis piam thiab kho qhov tshuaj raws li.

Thawj hypercholesterolemia thiab txuas (sib xyaw) hyperlipidemia: rau feem ntau cov neeg mob - 10 mg ib hnub ib zaug, qhov kev kho mob tshwm sim nyob rau hauv 2 lub lis piam thiab feem ntau nce mus txog qhov siab tshaj plaws nyob rau hauv 4 lub lis piam, nrog kev kho mob ntev, cov nyhuv tseem nyob.

Homozygous tsev neeg hypercholesterolemia: 80 mg ib zaug ib hnub (feem ntau, txoj kev kho tau ua rau cov ntsiab lus ntawm LDL-C los ntawm 18-45%).

Mob ntshav khov ntau heev hauv cov neeg mob cov menyuam yaus: Qhov pom zoo kom pib noj yog 10 mg ib hnub ib zaug. Cov koob tshuaj yuav raug nce ntxiv mus rau 80 mg ib hnub nyob rau hauv raws li cov chaw kuaj mob teb thiab kam rau ua. Cov koob tshuaj yuav tsum tau xaiv ib tus kheej coj mus rau hauv tus account lub hom phiaj pom zoo ntawm kev kho mob.

Siv rau cov neeg mob mob siab: saib "Contraindications."

Muab rau cov neeg mob raum tsis ua haujlwm: Kab mob hauv lub raum tsis cuam tshuam rau qhov kev xav ntawm Atoris® nyob rau hauv cov ntshav ntshav los yog cov neeg kawm poob qis hauv cov ntsiab lus ntawm LDL-C, yog li cov koob tshuaj hloov kho tsis tas yuav tsum tau ua.

Siv rau cov neeg laus: tsis muaj kev sib txawv hauv kev nyab xeeb, kev ua tau zoo, lossis kev ua tiav ntawm lub hom phiaj ntawm kev kho lipid-txo qis hauv cov neeg laus piv rau cov pej xeem.

Sab sij huam

mob hauv caj pas thiab lub ntsws, lub qhov ntswg

dyspepsia, xeev siab, pom, mob plab, duav, duav, raws plab

mob caj pas, mob hauv nqua, mob leeg, myalgia, myositis, mob myopathy

qhov ntsuas tsis zoo ntawm lub siab ua haujlwm, nce ntshav dej creatine phosphokinase (CPK)

leeg tsis muaj zog, mob caj dab

malaise, kub taub hau

kev tshwm sim ntawm cov qe ntshav dawb hauv lub tso zis

Cov kev mob tshwm sim hauv qab no tau pom nyob rau hauv cov kev tshawb fawb tom qab muag:

kev tsis haum tshuaj (suav nrog anaphylaxis)

hnyav

hypesthesia, amnesia, kiv taub hau, saj perversion

Stevens-Johnson syndrome, mob toxic epidermal necrolysis, erythema multiforme, mob ua pob ua paug

rhabdomyolysis, mob nraub qaum

mob hauv siab, peripheral edema, nkees

Cov Yuav Tsum Tau Ua

muaj qhov tsis haum xeeb rau ib qho twg ntawm cov yeeb tshuaj

kev mob siab rau daim siab lossis cov ntshav dej muaj ntshav siab hloov pauv ntau dua (ntau dua 3 zaug piv nrog kev txwv qis dua ntawm ib txwm) uas tsis paub lub hauv paus

cev xeeb tub thiab lactating cov poj niam, nrog rau cov poj niam uas muaj hnub nyoog yug me nyuam uas tsis siv txoj kev ua kom muaj txiaj ntsig txaus

cov neeg mob uas muaj keeb kwm lactose tsis txaus ntseeg, LAPP-lactase enzyme deficiency, glucose-galactose malabsorption

Cov tshuaj sib cuam tshuam

Txoj kev pheej hmoo ntawm kev tsim myopathy nce ntxiv thaum kho nrog HMG-CoA reductase inhibitors thiab siv tib lub sijhawm cyclosporin, derivatives ntawm fibric acid, nicotinic acid thiab cytochrome P450 3A4 inhibitors (erythromycin, antifungal agents ntsig txog azoles).

P450 3A4 Cov Tshuaj Hluav Taws Xob: atorvastatin yog metabolized los ntawm cytochrome P450 3A4. Kev siv tib txhij ntawm atorvastatin thiab cytochrome P450 3A4 inhibitors tuaj yeem ua rau nce ntshav ntau ntawm atorvastatin. Qib kev sib cuam tshuam thiab kev muaj zog ntawm cov nyhuv yog nyob ntawm qhov txawv txav ntawm kev txiav txim ntawm cytochrome P450 3A4.

Tus Ntaus Tus Ntaus: atorvastatin thiab nws cov metabolites yog cov ຍ່ອຍ ntawm OATP1B1 transporter. OATP1B1 inhibitors (piv txwv li, cyclosporine) yuav ua rau kom muaj kev nyab xeeb ntawm atorvastatin. Kev siv tib txhij ntawm 10 mg ntawm Atoris® thiab cyclosporine (5.2 mg / kg / hnub) ua rau muaj kev nce ntxiv ntawm atorvastatin los ntawm 7,7 lub sijhawm.

Erythromycin / clarithromycin: nrog kev siv tib txhij ntawm atorvastatin thiab erythromycin (500 mg plaub zaug hauv ib hnub) lossis clarithromycin (500 mg ob zaug ib hnub), uas inhibit cytochrome P450 3A4, ib qho kev nce siab ntawm atorvastatin hauv cov ntshav ntshav tau pom.

Protease inhibitors: concomitant siv atorvastatin nrog protease inhibitors hu ua cytochrome P450 3A4 inhibitors tau nrog los ntawm kev nce ntshav ntau dua ntawm atorvastatin.

Diltiazem hydrochloride: tib lub sijhawm siv Atoris® (40 mg) thiab diltiazem (240 mg) ua rau muaj kev nce siab ntawm cov tshuaj atorvastatin hauv cov ntshav ntshav.

Cimetidine: kev kawm txog kev cuam tshuam ntawm atorvastatin thiab cimetidine tsis tau qhia txog kev sib cuam tshuam hauv chaw kho mob.

Itraconazole: Kev siv tshuaj ib txhij ntawm Atoris® (20 mg-40 mg) thiab itraconazole (200 mg) ua rau muaj kev nce ntxiv ntawm AUC ntawm atorvastatin.

Cov kua txiv kab ntxwv qaub: muaj ib lossis ob qho sib xyaw uas tiv thaiv CYP 3A4 thiab tuaj yeem nce qhov tshuaj atorvastatin nyob rau hauv cov ntshav ntshav, tshwj xeeb tshaj yog kev noj cov txiv kab ntxwv qaub ntau dhau (ntau tshaj li 1.2 liv ib hnub).

Cov kws kho mob ntawm cytochrome P450 3A4: tib lub sij hawm siv Atoris® nrog cytochrome P450 3A4 inducers (efavirenz, rifampin) tuaj yeem ua rau kom txo qis ntshav plasma ntau ntawm atorvastatin. Xav txog lub tshuab ob ntawm rifampin kev txiav txim siab (induction ntawm cytochrome P450 3A4 thiab inhibition ntawm OATP1B1 hloov enzyme hauv daim siab), nws raug nquahu kom muab Atoris® tib lub sijhawm nrog rifampin, txij li thaum noj Atoris® tom qab noj rifampin ua rau txo qis hauv theem ntawm atorvastatin hauv ntshav ntshav.

Antacids: kev sib xyaw ua ke ntawm kev ncua kev kawm uas muaj cov magnesium thiab aluminium hydroxides txo qhov kev txiav txim siab ntawm atorvastatin hauv cov ntshav ntshav los ntawm li ntawm 35%, txawm li cas los xij, qhov kev poob qis hauv cov ntsiab lus ntawm LDL-C tsis tau hloov pauv.

Antipyrine: Atoris® tsis cuam tshuam rau lub pharmacokinetics ntawm antipyrine, yog li ntawd, kev cuam tshuam nrog lwm cov tshuaj metabolized los ntawm tib lub cytochrome isoenzymes tsis xav tau.

Colestipol: nrog rau kev siv tib lub sijhawm ntawm colestipol, qhov kev coj ntawm atorvastatin hauv cov ntshav ntshav poob qis li 25%, txawm li cas los xij, cov lipid-txo cov nyhuv ntawm kev sib xyaw ntawm atorvastatin thiab colestipol ntau dua li qhov ntawm txhua cov tshuaj ib leeg zuj zus.

Digoxin: Nrog kev rov ua dua ntawm cov digoxin thiab atorvastatin ntawm koob tshuaj 10 mg, qhov sib npaug ntawm cov digoxin hauv cov ntshav ntshav tsis hloov. Txawm li cas los xij, thaum digoxin tau siv nrog kev sib xyaw nrog atorvastatin ntawm ib koob ntawm 80 mg / hnub, qhov kev txiav txim siab ntawm digoxin nce ntxiv txog 20%. Cov neeg mob tau txais digoxin ntau ntxiv nrog Atoris® xav tau kev soj ntsuam kom tsim nyog.

Azithromycin: nrog kev siv atorvastatin sib xyaw ua ke (10 mg ib hnub ib zaug) thiab azithromycin (500 mg ib hnub ib zaug), cov tshuaj atorvastatin hauv cov ntshav tsis hloov.

Qhov ncauj txwv tsis pub muaj: nrog kev siv atorvastatin thiab kev noj tshuaj ntau qhov ncauj muaj norethindrone thiab ethinyl estradiol, muaj qhov nce ntxiv ntawm AUC ntawm norethindrone thiab ethinyl estradiol txog li 30% thiab 20%, feem. Cov nyhuv no yuav tsum raug txiav txim siab thaum xaiv qhov ncauj tawm tsam rau tus poj niam noj Atoris®.

Warfarin: Tsis muaj qhov sib cuam tshuam loj ntawm kev sib cuam tshuam ntawm atorvastatin nrog warfarin raug kuaj pom.

Amlodipine: nrog rau kev siv tib txhij ntawm atorvastatin thiab amlodipine 10 mg, lub pharmacokinetics ntawm atorvastatin hauv lub xeev equilibrium tsis hloov.

Fusidic acid: cov kev tshawb fawb ntawm kev sib cuam tshuam ntawm atorvastatin thiab fusidic acid tsis tau ua, txawm li cas los xij, cov mob ntawm rhabdomyolysis nrog lawv siv tib txhij tau tshaj tawm hauv kev tshawb fawb tom qab kev lag luam. Yog li, cov neeg mob yuav tsum tau saib xyuas thiab, yog tias tsim nyog, Kev kho Atoris® yuav raug tshem tawm ib ntus.

Lwm txoj kev kho kom zoo: thaum siv atorvastatin ua ke nrog cov tshuaj tiv thaiv kab mob thiab estrogens, qhov kev sib txuam tsis tseem ceeb hauv lub tsev kho mob tsis tau pom.

Cov lus qhia tshwj xeeb

Ua rau daim siab

Tom qab kho nrog atorvastatin, qhov tseem ceeb (ntau dua 3 zaug hauv qhov sib piv nrog qhov tsis pub tsawg tshaj qhov ib txwm) tau nce siab ntxiv cov kev ua ub no ntawm "mob siab" transaminases tau sau tseg.

Ib qho kev nce siab ntxiv hauv kev ua haujlwm ntawm hepatic transaminases feem ntau tsis muaj kab mob daj ntseg lossis lwm yam kev kuaj mob hauv lub cev. Nrog rau qhov txo qis dua ntawm cov tshuaj atorvastatin, ib ntus lossis ua tiav tsis raug tshuaj, cov haujlwm ntawm hepatic transaminases rov qab mus rau nws qhov qub. Feem ntau ntawm cov neeg mob txuas ntxiv noj atorvastatin hauv kev txo qis yam tsis muaj teeb meem.

Nws yog ib qho tsim nyog yuav tau soj ntsuam daim siab kev ua haujlwm hauv lub sijhawm thaum tag nrho kev kho mob, tshwj xeeb tshaj yog thaum pom cov tsos mob ntawm daim siab tshwm sim. Nyob rau hauv cov ntaub ntawv ntawm kev nce hauv cov ntsiab lus ntawm hepatic transaminases, lawv cov kev ua haujlwm yuav tsum tau saib xyuas kom txog thaum cov kev txwv ntawm kev suav tau mus txog. Yog tias nce hauv AST lossis ALT kev ua haujlwm los ntawm ntau dua 3 zaug piv nrog kev ntsuas siab ntawm tus neeg ua haujlwm siab, nws raug nquahu tias cov koob tshuaj yuav raug txo lossis tshem tawm.

Skeletal leeg ua

Thaum sau tshuaj Atoris® hauv kev tiv thaiv hypolipidemic nrog kev sib txuas ntawm cov tshuaj fibroic acid, erythromycin, immunosuppressants, azole antifungal tshuaj los yog nicotinic acid, tus kws kho mob yuav tsum ua tib zoo ntsuas cov txiaj ntsig thiab kev pheej hmoo ntawm kev kho mob thiab soj ntsuam cov neeg mob kom paub qhov mob lossis tsis muaj zog ntawm cov leeg, tshwj xeeb tshaj yog thaum thawj zaug lub hlis ntawm kev kho mob thiab lub sij hawm uas nce ntxiv ntawm ib qho tshuaj twg. Nyob rau tej qhov xwm txheej zoo li no, kev txiav txim siab ntawm CPK cov haujlwm txhua lub sijhawm tuaj yeem pom zoo, txawm hais tias kev saib xyuas zoo li no tsis tiv thaiv kev txhim kho kev mob myopathy. Atorvastatin tuaj yeem ua rau nce hauv creatine phosphokinase kev ua ub no.

Thaum siv atorvastatin, muaj qee yam mob ntawm rhabdomyolysis nrog mob raum tsis ua hauj lwm vim myoglobinuria tau piav qhia. Atoris® kev kho mob yuav tsum tau txiav tawm ib ntus lossis txiav tawm ib qho txuas ntxiv yog tias muaj cov cim ntawm lub pob txha myopathy lossis muaj kev pheej hmoo rau kev txhim kho lub raum tsis ua haujlwm vim mob rhabdomyolysis (piv txwv li, mob hnyav, mob ntshav qis, kev phais mob loj, kev poob plig, metabolic, endocrine thiab electrolyte cuam tshuam thiab kev tswj hwm tsis tuaj yeem).

Cov ntaub ntawv rau tus neeg mob: cov neeg mob yuav tsum tau ceeb toom tias lawv yuav tsum tau sab laj nrog kws kho mob tam sim ntawd yog tias qhov mob tsis qhia lossis qhov tsis muaj zog ntawm cov leeg yuav tshwm sim, tshwj xeeb yog tias lawv nrog mob malaise lossis kub taub hau.

Siv nrog ceev faj hauv cov neeg mob uas quav cawv thiab / lossis raug mob los ntawm daim siab mob (keeb kwm).

Cov neeg mob uas tsis muaj mob plawv (CHD) nrog rau kev mob hlab ntsha tawg lossis hloov ischemic sai (TIA) qhia tias muaj kev mob ntshav siab ntau dua uas pib tau txais atorvastatin ntawm koob ntawm 80 mg piv nrog cov neeg mob uas tau txais cov placebo. Cov neeg mob hemorrhagic mob stroke yuav pom muaj kev pheej hmoo ntxiv ntawm cov mob stroke ib zaug. Txawm li cas los xij, cov neeg mob noj atorvastatin 80 mg muaj tsawg dua qhov mob stroke ntawm txhua yam thiab tsawg dua kev mob plawv.

Cev xeeb tub thiab lactation

Cov poj niam ntawm kev muaj me nyuam hnub nyoog yuav tsum siv txoj kev ua kom muaj txiaj ntsig thaum lub sijhawm kho. Atoris® tuaj yeem raug samfwm rau cov pojniam muaj hnub nyoog yug menyuam tsuas yog tias qhov tshwm sim ntawm cev xeeb tub muaj tsawg heev, thiab tus neeg mob tau paub txog qhov kev pheej hmoo rau tus menyuam hauv lub sijhawm kho.

Tshwj Xeebcov lus ceeb toom muab tub lim

Atoris® muaj cov lactose. Cov neeg mob uas tsis tshua muaj mob cov kab mob ua rau tsis txaus ntseeg tsis txaus siab rau txoj kev tsis haum, Lapp lactase deficiency, lossis glucose galactose malabsorption yuav tsum tsis txhob noj cov tshuaj no. Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav lub tsheb thiab muaj cov phom sij phom sij

Muab cov kev phiv los ntawm cov tshuaj, ceev faj yuav tsum tau siv thaum tsav tsheb thiab lwm yam uas yuav muaj kev phom sij.

Nrog saib xyuas

Kev quav dej caw, keeb kwm ntawm tus kab mob siab.
Hauv cov neeg mob uas muaj kev pheej hmoo rau rhabdomyolysis (mob raum, mob ntshav qab zib, mob rau cov leeg mob hauv keeb kwm ntawm tus neeg mob lossis tsev neeg keeb kwm, cov tshuaj lom los ntawm HMG-CoA reductase inhibitors ntawm statins lossis fibrates rau cov leeg nqaij, keeb kwm muaj kab mob siab thiab / / lossis cov neeg mob uas haus cawv ntau, cov neeg laus laus dua 70 xyoo rov hauv, qhov xwm txheej uas nce ntawm ntshav ntau dua ntawm atorvastatin xav tias yuav, piv txwv li, kev cuam tshuam nrog lwm yam tshuaj).

Siv thaum cev xeeb tub thiab thaum pub niam mis

Atoris® yog sib kis thaum cev xeeb tub thiab thaum pub niam mis. Kev tshawb fawb tsiaj qhia tias kev pheej hmoo rau tus me nyuam hauv plab yuav dhau qhov txiaj ntsig tau rau leej niam.
Hauv cov poj niam ntawm lub hnub nyoog yug me nyuam uas tsis siv txoj hauv kev txhim kho kom muaj txiaj ntsig, kev siv Atoris® tsis pom zoo. Thaum npaj kev cev xeeb tub, koj yuav tsum tsum tsis siv Atoris® yam tsawg 1 lub hlis ua ntej koj cev xeeb tub.
Tsis muaj pov thawj ntawm kev faib cov atorvastatin nrog rau niam mis. Txawm li cas los xij, nyob rau qee hom tsiaj thaum lub sijhawm lactation, qhov concentration ntawm atorvastatin hauv cov ntshav cov ntshav thiab hauv cov mis yog zoo ib yam. Yog tias nws yuav tsum tau siv cov tshuaj Atoris® lub sijhawm pub niam mis, txhawm rau kom tsis txhob muaj kev phom sij ntawm cov menyuam mos, kev pub niam mis yuav tsum tau tsum.

Tsuas tshuaj thiab tswj hwm

Ua ntej pib siv cov tshuaj Atoris®, tus neeg mob yuav tsum pauv mus rau qhov kev noj haus uas ua kom muaj qhov txo qis ntawm cov lipids hauv cov ntshav ntshav, uas yuav tsum tau pom thaum lub sijhawm kho tag nrho nrog cov tshuaj. Ua ntej pib txoj kev kho mob, koj yuav tsum tau sim ua kom tiav kev tswj hwm ntawm hypercholesterolemia los ntawm kev tawm dag zog thiab kev poob phaus hauv cov neeg mob rog, nrog rau kev kho mob rau lwm tus kab mob.
Cov tshuaj tau noj ntawm qhov ncauj, tsis hais lub sijhawm noj mov. Cov koob tshuaj ntawm cov tshuaj txawv ntawm 10 mg rau 80 mg ib hnub ib zaug thiab raug xaiv los xav txog thawj zaug kev xav ntawm LDL-C hauv cov ntshav ntshav, lub hom phiaj ntawm txoj kev kho thiab cov tib neeg siv tshuaj kho kom zoo.
Atoris® tuaj yeem nqa ib zaug thaum lub sijhawm txhua hnub, tab sis tib lub sijhawm txhua hnub. Kev kho mob nyhuv yog pom tom qab 2 lub lis piam ntawm kev kho mob, thiab cov txiaj ntsig siab tshaj plaws yuav tshwm sim tom qab 4 lub lis piam.
Thaum pib kho thiab / lossis thaum qhov nce ntxiv, nws yog qhov yuav tsum tau saib xyuas qhov kev nkag siab ntawm lipids hauv cov ntshav ntshav txhua 2-4 lub lis piam thiab kho qhov tshuaj raws li.
Thawj hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia
Rau feem ntau cov neeg mob, qhov kev pom zoo ntawm Atoris® yog 10 mg ib hnub ib zaug, qhov kev kho mob tshwm sim nws tus kheej tsis pub dhau 2 lub lis piam thiab feem ntau nce mus txog qhov siab kawg tom qab 4 lub lis piam. Nrog kev kho mob ntev, cov nyhuv cuam tshuam.
Homozygous tsev neeg hypercholesterolemia
Feem ntau, 80 mg yog tau sau tseg ib hnub ib hnub (qhov kev txo qis ntawm cov concentration ntawm LDL-C hauv ntshav yog li 18-45%).
Heterozygous tsev neeg hypercholesterolemia
Qhov tshuaj thawj zaug yog 10 mg rau ib hnub. Cov koob tshuaj yuav tsum tau xaiv ib tus zuj zus thiab ntsuas qhov tseeb ntawm qhov koob tshuaj txhua 4 lub lis piam nrog kev nce ntxiv txog 40 mg ib hnub twg. Tom qab ntawd, txawm tias qhov koob tshuaj yuav raug nce ntxiv txog qhov siab tshaj ntawm 80 mg rau ib hnub, lossis nws yog ua tau los sib txuas cov tshuaj tiv thaiv kab mob sib txuas nrog kev siv atorvastatin ntawm ib koob ntawm 40 mg ib hnub twg.
Kev Tiv Thaiv Kab Mob Tiv Thaiv Kab Mob
Hauv kev tshawb nrhiav ntawm kev tiv thaiv kev tiv thaiv thawj zaug, koob tshuaj atorvastatin yog 10 mg rau ib hnub. Qhov koob tshuaj ntxiv yuav tsim nyog kom ua tiav LDL-C tus nqi raws li cov lus qhia tam sim no.
Siv rau hauv cov menyuam yaus ntawm 10 txog 18 xyoo nrog rau kev tiv thaiv heterozygous tsev neeg hypercholesterolemia
Qhov pom zoo kom pib noj yog 10 mg ib hnub ib zaug. Qhov kev txhaj tshuaj yuav raug nce ntxiv mus rau 20 mg ib hnub twg, nyob ntawm qhov siv los soj ntsuam. Kev paub nrog ib koob ntau tshaj 20 mg (sib haum rau ib koob ntawm 0.5 mg / kg) yog txwv.
Cov koob tshuaj ntawm cov tshuaj yuav tsum raug xaiv raws li lub hom phiaj ntawm kev kho lipid-txo qis. Kev hloov koob tshuaj yuav tsum tau ua ntawm ncua sijhawm ntawm 1 lub sijhawm hauv 4 lub lis piam lossis ntau dua.
Daim siab ua haujlwm
Yog tias lub siab ua haujlwm tsis txaus, koob tshuaj Atoris® yuav tsum tau txo, nrog kev soj ntsuam tas li ntawm kev ua haujlwm ntawm "daim siab" hloov pauv: aspartate aminotransferase (AST) thiab alanine aminotransferase (ALT) hauv ntshav ntshav.
Tsis hlauv
Lub raum ua haujlwm tsis zoo cuam tshuam rau lub zog ntawm atorvastatin lossis qhov neeg kawm poob qis hauv kev ua haujlwm ntawm lub siab ntawm LDL-C hauv ntshav, yog li ntawd, kev hloov tshuaj ntau dua yog tsis xav tau (saib ntu "Pharmacokinetics").
Cov neeg laus cov neeg mob
Tsis muaj qhov sib txawv hauv kev siv tshuaj thiab kev nyab xeeb ntawm atorvastatin hauv cov neeg mob laus piv nrog cov pej xeem sawv daws, kev hloov tshuaj yog tsis xav tau (saib Ntu Pharmacokinetics).
Siv nrog rau lwm cov tshuaj
Yog tias tsim nyog, kev siv ib txhij nrog cyclosporine, telaprevir lossis kev sib xyaw ntawm tipranavir / ritonavir, cov koob tshuaj Atoris® yuav tsum tsis pub tshaj 10 mg / hnub (saib nqe lus "Cov lus qhia tshwj xeeb").
Kev ceev faj yuav tsum tau siv thiab kev siv tshuaj qis tshaj plaws ntawm atorvastatin yuav tsum tau siv thaum nws siv nrog HIV tiv thaiv kab mob tiv thaiv kab mob, kis kab mob siab C tiv thaiv kab mob siab (boceprevir), clarithromycin thiab itraconazole.
Cov lus pom zoo ntawm Lavxias Society of Cardiology, Kev Koom Tes Hauv Tebchaws rau Kev Tshawb Fawb ntawm Atherosclerosis (NLA) thiab Lavxias Society of Cardiosomatic Rehabilitation thiab Secondary Kev Tiv Thaiv (RosOKR)
(Kev kho dua V 2012)
Cov tshuaj zoo siab tshaj plaws ntawm LDL-C thiab LDL rau cov neeg mob muaj feem ntau yog: ≤ 2.5 mmol / L (lossis ≤ 100 mg / dL) thiab ≤ 4.5 mmol / L (lossis ≤ 175 mg / dL), feem thiab rau cov neeg mob uas muaj kev pheej hmoo siab: ≤ 1.8 mmol / l (lossis ≤ 70 mg / dl) thiab / lossis, yog tias nws tsis tuaj yeem ua tiav, nws raug nquahu kom txo qis ntawm LDL-C los ntawm 50% los ntawm tus nqi pib thiab ≤ 4 mmol / l (lossis ≤ 150 mg / dl), feem.

Sab sij huam

Kis thiab cov kab mob cab:
feem ntau: nasopharyngitis.
Kev cuam tshuam los ntawm cov ntshav thiab cov lymphatic system:
tsis tshua muaj: thrombocytopenia.
Lub cev tsis muaj zog tiv thaiv kab mob:
feem ntau: ua xua,
tsawg tsawg: anaphylaxis.
Ua txhaum ntawm cov metabolism thiab khoom noj khoom haus:
pheej: yuag yuag, tsis nco qab,
Tsis tshua muaj heev: hyperglycemia, ntshav qab zib tsawg.
Mob Hlwb:
feem ntau: pw ntxhov siab, suav nrog insomnia thiab "npau suav phem" npau suav,
zaus tsis paub: kev nyuaj siab.
Ua txhaum ntawm lub paj hlwb:
feem ntau: mob taub hau, kiv taub hau, mob caj dab, mob asthenic,
tsis xws luag: muaj hlwb neuropathy, mob ntshav qab zib, ua rau tsis hnov ​​qab, poob lossis ploj nco.
Kev hnov ​​lus thiab lub labyrinth tsis meej:
ncaw: tinnitus.
Kev ua tsis taus ntawm lub tshuab ua pa, hauv siab thiab mediastinal kabmob:
feem ntau: mob mob caj pas, txhawm ntswg,
zaus tsis paub: raug cov kab mob sib txawv hauv lub ntsws (feem ntau yog siv ntev heev).
Digestive ntshawv siab:
feem ntau: cem quav, dyspepsia, xeev siab, raws plab, mob plab (tsam plab), mob plab,
ncus: ntuav, pancreatitis.
Kev ua txhaum ntawm daim siab thiab kab mob:
tsis tshua muaj: kab mob siab, mob siab tawv nqaij daj ntseg.
Kev ua tsis taus los ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous:
feem ntau: tawv nqaij ua pob, khaus,
pheej: urticaria,
muaj tsawg kawg: angioedema, alopecia, ua pob liab vog, mob erythema multiforme, Stevens-Johnson syndrome, cov kab mob ua paug lom hauv lub cev.
Kev ua txhaum ntawm cov leeg nqaij thiab pob qij txha:
feem ntau: myalgia, mob caj dab, mob nraub qaum, o ntawm pob qij txha,
tsis tuaj yeem: mob raum, mob leeg,
tsis tshua muaj: myositis, rhabdomyolysis, tendopathy (qee qhov mob txha caj qaum),
zaus tsis paub: mob ntawm kev tiv thaiv-mediated necrotizing myopathy.
Ua txhaum ntawm ob lub raum thiab lub plab:
tsis nkag siab: lub raum tsis ua haujlwm.
Ua txhaum ntawm lub qau thiab lub qog mammary:
yooj yim: kev ua niam txiv tsis ua hauj lwm,
tsis tshua muaj: gynecomastia.
Kev cuam tshuam dav dav thiab cuam tshuam ntawm qhov chaw txhaj tshuaj:
feem ntau: peripheral edema,
ncus: mob hauv siab, kub siab, nkees, kub cev.
Kuaj thiab ntsuas cov ntaub ntawv:
tsis sib xws: nce kev ua ntawm aminotransferases (AST, ALT), kev ua si ntau ntxiv ntawm cov ntshav creatine phosphokinase (CPK) hauv ntshav ntshav,
Tsis tshua muaj heev: muaj kev xav ntau ntxiv ntawm glycosylated hemoglobin (HbA1).
Kev sib raug zoo ntawm qee qhov teebmeem tsis txaus siab nrog rau kev siv tshuaj Atoris®, uas tau hais ua "muaj tsawg kawg", tseem tsis tau tsim. Yog tias muaj qhov tshwm sim tsis pom tshwm sim ntau, yuav tsum siv Atoris® txoj kev siv.

Kev cuam tshuam nrog lwm yam tshuaj

Kev siv cov tshuaj atorvastatin nrog cyclosporine, tshuaj tua kab mob (erythromycin, clarithromycin, chinupristine / dalphopristine), HIV tiv thaiv cov tshuaj tiv thaiv kab mob (indinavir, ritonavir), cov tshuaj tua kab mob (fluconazole, itraconazole, ketoconazole) lossis nrog nefazatone yuav nce ntxiv. nce kev pheej hmoo ntawm kev tsim myopathy nrog rhabdomyolysis thiab lub raum tsis ua haujlwm. Yog li, nrog kev siv txig ntawm erythromycin TCmax, atorvastatin lengthens los ntawm 40%. Txhua cov tshuaj no inhibit CYP3A4 isoenzyme, uas koom nrog cov metabolism hauv atorvastatin hauv lub siab. Kev sib cuam tshuam zoo sib xws yog ua tau nrog kev siv tib lub sij hawm ntawm atorvastatin nrog fibrates thiab nicotinic acid hauv lipid txo cov koob tshuaj (ntau dua 1 g nyob rau ib hnub).
Kev siv ezetimibe yog txuam nrog kev txhim kho cov kev phiv tshuaj, suav nrog rhabdomyolysis, los ntawm cov leeg hlwb. Kev pheej hmoo ntawm cov kev tsis haum xeeb no nce ntxiv nrog kev siv ezetimibe thiab atorvastatin tib lub sijhawm. Saib xyuas ze yog pom zoo rau cov neeg mob no.
Kev siv tib lub sij hawm ntawm atorvastatin ntawm ib koob ntawm 40 mg nrog diltiazem ntawm ib koob ntawm 240 mg ua rau kev nce siab ntawm cov tshuaj atorvastatin hauv cov ntshav ntshav.
CYP3A4 Isoenzyme Inductors
Kev siv ua ke ntawm atorvastatin nrog inducers ntawm isoenzyme CYP3A4 (piv txwv li efavirenz, rifampicin lossis Hypericum perforatum) tuaj yeem ua rau txo qis ntawm cov tshuaj atorvastatin hauv ntshav ntshav. Vim tias ob lub tshuab sib cuam tshuam ntawm kev sib raug zoo nrog rifampicin (inducer ntawm CYP3A4 isoenzyme thiab hepatocyte thauj protein inhibitor OATP1B1), kev tswj hwm qeeb ntawm atorvastatin pom zoo, txij li thaum siv tib lub sijhawm ntawm atorvastatin thiab rifampicin ua rau muaj kev txo qis ntawm cov tshuaj atorvastatin hauv ntshav ntshav. Tsis muaj xov xwm tshwm sim rau cov nyhuv ntawm rifampicin ntawm qhov kev sib xyaw ntawm atorvastatin hauv hepatocytes, yog li ntawd, yog tias siv ib txhij tsis tuaj yeem zam dhau, cov txiaj ntsig ntawm kev sib txuam yuav tsum ua tib zoo saib xyuas thaum kho.
Txij li thaum atorvastatin metabolized los ntawm isoenzyme CYP3A4, kev siv tib txhij ntawm atorvastatin nrog tshuaj tiv thaiv ntawm isoenzyme CYP3A4 tuaj yeem ua rau muaj kev nce ntxiv ntawm cov tshuaj atorvastatin hauv cov ntshav ntshav.
OATP1B1 thauj cov tshuaj tiv thaiv protein (xws li, cyclosporine) yuav nce cov bioavailability ntawm atorvastatin.
Nrog rau kev siv ua ke nrog antacids (raug tshem tawm ntawm magnesium hydroxide thiab aluminium hydroxide), cov tshuaj atorvastatin hauv cov ntshav ntshav poob qis.
Nrog kev siv atorvastatin nrog colestipol, kev siv atorvastatin hauv cov ntshav ntshav yog txo 25%, tab sis cov tshuaj kho ntawm kev sib xyaw yog siab dua cov nyhuv ntawm atorvastatin ib leeg.
Kev siv cov tshuaj atorvastatin nrog rau cov tshuaj uas txo qis ntawm cov tshuaj hormones endogenous steroid (suav nrog cimetidine, ketoconazole, spironolactone) yuav ua rau muaj kev pheej hmoo ntawm txo qis cov tshuaj hormones endogenous steroid (ceev faj yuav tsum tau siv).
Hauv cov neeg mob tib lub sijhawm tau txais 80 mg ntawm atorvastatin thiab digoxin, cov concentration ntawm digoxin hauv cov ntshav ntshav nce ntxiv li ntawm 20%, yog li, cov neeg mob zoo li no yuav tsum tau saib xyuas.
Nrog tib lub sijhawm siv atorvastatin nrog tshuaj ntxiv rau kev tswj hwm qhov ncauj (norethisterone thiab ethinyl estradiol), nws yog qhov ua tau kom nce kev nqus ntawm kev tswj kom tsis txhob muaj menyuam yaus thiab nce lawv cov kev xav hauv ntshav ntshav. Kev xaiv ntawm kev tswj kom tsis txhob muaj menyuam yaus nyob rau hauv cov poj niam noj atorvastatin yuav tsum tau saib xyuas.
Kev siv tib txhij ntawm atorvastatin nrog warfarin thaum ntxov ntxov tuaj yeem ua rau muaj txiaj ntsig ntawm warfarin ntawm cov ntshav coagulation (txo lub sijhawm prothrombin). Cov nyhuv no ploj mus tom qab 15 hnub ntawm kev siv cov tshuaj no ib txhij.
Txawm hais tias qhov tseeb hais tias kev tshawb fawb txog kev siv tib lub sij hawm ntawm colchicine thiab atorvastatin tsis tau ua, muaj cov ntaub ntawv qhia txog kev txhim kho myopathy nrog txoj kev sib xyaw no. Nrog rau kev siv txaws ntawm atorvastatin thiab colchicine, kev ceev faj yuav tsum siv.
Nrog rau kev siv tib txhij ntawm atorvastatin thiab terfenadine, thaj chaw kho mob tseem ceeb hloov pauv hauv pharmacokinetics ntawm terfenadine tsis tau kuaj pom.
Atorvastatin tsis cuam tshuam rau pharmacokinetics ntawm phenazone.
Kev siv ntau yam nrog cov protease inhibitors ua rau nce ntshav ntau ntxiv ntawm atorvastatin.
Nrog rau kev siv tib txhij ntawm atorvastatin ntawm koob tshuaj 80 mg thiab amlodipine ntawm koob tshuaj 10 mg, pharmacokinetics ntawm atorvastatin hauv lub xeev equilibrium tsis tau hloov pauv.
Muaj qee tus neeg mob rhabdomyolysis hauv cov neeg mob uas siv atorvastatin thiab fusidic acid.
Kho sab nraud
Thaum siv atorvastatin nrog cov tshuaj tiv thaiv kab mob thiab estrogens ua ib feem ntawm kev hloov kho kho, tsis muaj cov cim ntawm qhov chaw tsis txaus siab hauv kev kho mob.
Kev siv cov txiv kab ntxwv kua txiv thaum lub sijhawm siv Atoris® tuaj yeem ua rau nce ntshav ntau dua ntawm atorvastatin. Hauv qhov no, cov neeg mob noj cov tshuaj Atoris® yuav tsum tsis txhob haus cov kua txiv kab ntxwv qaub ntau dua li ntawm 1.2 litres ib hnub.

Noj ntau dhau

Cov tsos mob: nce phiv.

Kev Kho Mob: tsis muaj ib qho tshwj xeeb tshuaj rau kev kho mob ntawm Atoris® overdose. Yog tias dhau ntawm kev siv tshuaj ntau dhau, kev kho mob yuav tsum tau nqa tawm ntawm qhov tsim nyog (raws li tus kws kho mob qhia). Txij li thaum cov tshuaj nquag khi rau cov ntshav plasma, qhov nce siab hauv Atoris® kev tshem tawm lub sijhawm hemodialysis yog qhov tsis zoo.

Daim Ntawv Tso Npe Sau Npe

Krka, hnub, Novo Mesto, Slovenia

Lub chaw nyob ntawm cov koomhaum uas lees txais thov nyiaj los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo (cov khoom lag luam) hauv koom pheej ntawm Kazakhstan

Krka Kazakhstan LLP, Kazakhstan, 050059, Almaty, Al-Farabi Ave. 19,

lub tsev 1 b, pem teb thib 2, 207 chaw ua haujlwm

tel.: +7 (727) 311 08 09

fax mus: +7 (727) 311 08 12

11.04.05

3D duab

Kev piav qhia ntawm daim ntawv tshuaj

Ntsiav tshuaj, 10 thiab 20 mg: puag ncig, me ntsis biconvex, them nrog ib zaj duab xis membrane ntawm cov xim dawb. Kink saib: dawb ntxhib nrog ib txheej zaj duab xis ntawm dawb los yog yuav luag dawb xim.

Ntsiav tshuaj, 30 mg: puag ncig, me ntsis biconvex, them nrog ib zaj duab xis daim nyias nyias ntawm cov xim dawb lossis yuav luag dawb, nrog lub bevel.

Ntsiav tshuaj, 40 mg: puag ncig, me ntsis biconvex, them nrog ib zaj duab xis daim nyias nyias ntawm dawb los yog yuav luag dawb. Kink saib: dawb ntxhib nrog ib txheej zaj duab xis ntawm dawb los yog yuav luag dawb xim.

Cov Tshuaj Hauv Tshuaj

Atorvastatin yog tus neeg saib xyuas hypolipidemic los ntawm pab pawg ntawm statins. Lub tshuab tseem ceeb ntawm kev ua ntawm atorvastatin yog qhov inhibition ntawm cov kev ua ntawm HMG-CoA reductase, ib qho enzyme uas catalyzes hloov dua siab tshiab ntawm HMG-CoA rau mevalonic acid. Qhov kev hloov pauv no yog ib qho ntawm cov txheej txheem ntxov tshaj plaws hauv cov kab txuas ntawm synthes ntawm Chs hauv lub cev. Atorvastatin kev tiv thaiv ntawm XC hluav taws xob ua rau cov neeg muaj zog ntawm cov LDL receptors hauv lub siab, ntxiv rau cov ntaub so ntswg. Cov receptors khi LDL cov roj ntsha thiab tshem tawm cov ntshav ntshav, uas ua rau kom txo qis hauv cov concentration ntawm LDL-C hauv cov ntshav.

Cov nyhuv antiatherosclerotic ntawm atorvastatin yog qhov tsim nyog ntawm nws cov nyhuv rau ntawm phab ntsa ntawm cov hlab ntsha thiab cov ntshav ua haujlwm. Atorvastatin inhibits kev sib txuas ntawm isoprenoids, uas yog kev loj hlob ntawm cov hlwb ntawm cov roj ntsha sab hauv. Nyob hauv kev cuam tshuam ntawm atorvastatin, endothelium-ywj pheej nthuav dav ntawm cov hlab ntshav nce ntxiv, qhov kev sib txuam ntawm LDL-C, LDL (Apo-B), triglycerides (TG) poob qis, thiab cov concentration ntawm HDL-HDL thiab Apolipoprotein A (Apo-A) nce.

Atorvastatin txo qis viscosity ntawm ntshav ntshav thiab cov kev ua ntawm qee yam coagulation yam thiab platelet aggregation. Vim qhov no, nws txhim kho hemodynamics thiab normalizes qhov mob ntawm coagulation system. HMG-CoA reductase inhibitors tseem cuam tshuam cov metabolism hauv macrophages, thaiv lawv cov kev ua kom zoo thiab tiv thaiv kev tawg ntawm atherosclerotic plaques.

Raws li txoj cai, txoj kev kho mob ntawm atorvastatin raug pom tom qab 2 lub lis piam ntawm kev kho mob, thiab cov txiaj ntsig siab tshaj plaws yuav tshwm sim tom qab 4 lub lis piam.

Atorvastatin ntawm koob tshuaj 80 mg txo qhov kev pheej hmoo ntawm kev tsim ischemic muaj teeb meem (suav nrog kev tuag los ntawm myocardial infarction) los ntawm 16%, kev pheej hmoo rov qab pw hauv tsev kho mob rau angina pectoris, nrog cov cim ntawm myocardial ischemia, los ntawm 26%.

Cov Tshuaj Pharmacokinetics

Atorvastatin nqus tau ntau, kwv yees 80% yog nqus los ntawm cov hnyuv. Kev ntsuas nqus thiab kev nqus ntawm cov ntshav ntshav nce ntxiv hauv kev faib ua feem. T_max thaj tsam li 1-2 teev .mua rau cov poj niam, T_max siab dua 20%, thiab AUC qis dua 10%. Qhov sib txawv ntawm cov khw muag tshuaj hauv cov neeg mob los ntawm lub hnub nyoog thiab poj niam txiv neej yog qhov tsis txaus ntseeg thiab tsis tas yuav hloov kho koob tshuaj.

Hauv cov neeg mob uas haus cawv ua lub siab T_max 16 npaug siab dua li ib txwm. Noj ib nyuag txo qhov nrawm thiab ncua sijhawm ntawm kev nqus ntawm cov tshuaj (los ntawm 25 thiab 9%, feem), tab sis qhov poob qis hauv kev ua siab ntawm LDL-C yog zoo li ntawd nrog kev siv atorvastatin tsis muaj zaub mov.

Atorvastatin bioavailability muaj tsawg (12%), cov kab ke ua haujlwm ntawm bioavailability ntawm kev tiv thaiv kev ua si tiv thaiv HMG-CoA reductase yog 30%. Qes mentsis bioavailability vim lub cev ua haujlwm ntawm lub cev (presystemic metabolism) nyob rau hauv txoj hnyuv thiab qhov pib nkag los ntawm lub siab.

Nruab Nrab V_d atorvastatin - 381 l. Ntau tshaj li 98% ntawm atorvastatin khi rau cov ntshav protein. Atorvastatin tsis hla qhov BBB. Metabolized feem ntau nyob hauv lub siab nyob rau hauv kev txiav txim ntawm isoenzyme CYP3A 4 ntawm cytochrome P450 nrog kev tsim cov pharmacologically nquag metabolites (ortho- thiab para-hydroxylated metabolites, cov khoom lag luam ntawm beta oxidation), uas ua rau kwv yees li 70% ntawm cov kev tiv thaiv tiv thaiv HMG-CoA reductase, rau 20-30 teev. Cov.

T_1/2 atorvastatin 14 h. Nws raug tso tawm feem ntau nrog cov kua tsib (nws tsis yog nyob rau ntawm qhov loj ntawm cov leeg mob hnyav, nws tsis raug tawm thaum mob hemodialysis). Kwv yees li 46% ntawm atorvastatin raug tawm hauv txoj hnyuv thiab tsawg dua 2% los ntawm lub raum.

Cov pab pawg neeg tshwj xeeb

Cov menyuam. Muaj cov ntaub ntawv txwv ntawm 8-lub limtiam qhib kev kawm ntawm cov tshuaj pharmacokinetics hauv cov menyuam yaus (hnub nyoog 6-17 xyoo) nrog heterozygous tsev neeg hypercholesterolemia thiab kev pib ua haujlwm ntawm LDL cov roj cholesterol ≥4 mmol / l, kho nrog atorvastatin hauv daim ntawv ntawm chewable ntsiav tshuaj ntawm 5 lossis 10 mg lossis ntsiav tshuaj, zaj duab xis-txheej, ntawm ib koob tshuaj 10 lossis 20 mg 1 zaug hauv ib hnub, ntsig txog. Qhov tseem ceeb tsuas yog covariate hauv tus qauv pharmacokinetic ntawm cov pej xeem tau txais atorvastatin yog lub cev hnyav. Kev pom tseeb ntawm kev tshem tawm atorvastatin hauv cov menyuam yaus tsis txawv qhov ntawd ntawm cov neeg mob cov neeg laus nrog ntsuas txhua qhov me me los ntawm lub cev nyhav. Hauv qhov ntau ntawm kev ua ntawm atorvastatin thiab o-hydroxyatorvastatin, qhov txo qis hauv LDL-C thiab LDL raug pom.

Cov neeg laus cov neeg mob. C_max hauv cov ntshav ntshav thiab AUC ntawm cov tshuaj hauv cov neeg mob laus (tshaj 65 xyoo) los ntawm 40 thiab 30%, feem, siab dua cov neeg mob cov neeg hluas. Tsis muaj qhov sib txawv hauv kev ua kom muaj txiaj ntsig thiab kev nyab xeeb ntawm cov tshuaj lossis hauv kev ua tiav cov hom phiaj ntawm kev kho lipid-txo qis hauv cov neeg laus piv rau cov pej xeem.

Lub raum khiav tsis zoo. Lub raum ua haujlwm tsis zoo cuam tshuam rau qhov kev txiav txim ntawm atorvastatin hauv ntshav ntshav lossis nws cov nyhuv ntawm lipid metabolism vim li ntawd, kev hloov tshuaj rau cov neeg mob uas lub raum tsis ua haujlwm tsis tas yuav tsum.

Lub siab ua haujlwm tsis zoo. Qhov kev kub siab ntawm cov tshuaj nce siab dua (C_max - kwv yees li 16 zaug, AUC - txog 11 zaug) hauv cov neeg mob uas lub siab ua mob rau lub siab ua pa (qib B raws li menyuam-Pugh kev faib tawm).

Kev taw qhia ntawm cov tshuaj Atoris ®

- raws li kev pabcuam rau kev noj zaub mov kom txo tau cov roj (cholesterol) tag nrho, cov roj cholesterol, LDL, apo-B thiab TG hauv cov ntshav ntshav hauv cov neeg mob, cov hluas thiab cov menyuam hnub nyoog 10 xyoo lossis tshaj saud nrog thawj hypercholesterolemia, suav nrog tsev neeg hypercholesterolemia (heterozygous) los yog sib xyaw ( sib xyaw) hyperlipidemia (hom IIa thiab IIb, feem, raws li kev faib tawm ntawm Fredrickson), thaum cov lus teb rau kev noj zaub mov noj thiab lwm yam tshuaj tsis yog tshuaj muaj txiaj ntsig,

- txhawm rau kom txo qis ntau Chs, Chs-LDL nyob rau hauv ntshav hauv cov neeg mob cov neeg laus nrog homozygous tsev neeg hypercholesterolemia raws li kev qhuas rau lwm cov lipid-txo kev kho mob (piv txwv li LDL apheresis), lossis yog tias tsis muaj kev kho mob no.

Kev tiv thaiv kab mob plawv:

- kev tiv thaiv ntawm cov kev mob plawv rau cov neeg mob cov neeg laus uas muaj kev pheej hmoo loj los ntawm kev txhim kho cov kab mob plawv, ntxiv rau kev txhim kho ntawm lwm yam kev pheej hmoo,

- kev tiv thaiv kab mob thib ob hauv kev mob plawv hauv cov neeg mob uas muaj mob plawv coronary (CHD) txhawm rau txo qis kev tuag, kev mob ntshav qab zib, mob ntshav txhaws, rov pw hauv tsev kho mob rau angina pectoris thiab qhov xav kom rov qab kho ntshav.

Cev xeeb tub thiab lactation

Cov tshuaj Atoris ® yog sib kis thaum cev xeeb tub thiab thaum pub niam mis. Kev tshawb fawb tsiaj qhia tias kev pheej hmoo rau tus me nyuam hauv plab yuav dhau qhov txiaj ntsig tau rau leej niam.

Hauv cov poj niam uas muaj hnub nyoog yug me nyuam uas tsis siv txoj hauv kev tiv thaiv kom muaj txiaj ntsig, kev siv Atoris ® tsis pom zoo. Thaum npaj kev cev xeeb tub, koj yuav tsum tsum tsis txhob siv Atoris least tsawg kawg 1 hlis ua ntej koj cev xeeb tub.

Tsis muaj pov thawj ntawm kev faib cov atorvastatin nrog rau niam mis. Txawm li cas los xij, qhov kev nkag siab ntawm atorvastatin hauv cov ntshav cov ntshav thiab cov mis ntawm cov lactating yog qhov zoo sib xws hauv qee hom tsiaj. Yog tias nws yuav tsum tau siv cov tshuaj Atoris ® lub sijhawm pub niam mis, txhawm rau kom tsis txhob muaj kev phom sij ntawm cov menyuam mos, kev pub mis niam yuav tsum tau tsum.

Daim ntawv tso tawm

Cov ntsiav tshuaj ua yeeb yaj kiab, 10 mg thiab 20 mg. 10 ntsiav tshuaj nyob rau hauv blister (blister sawb ntim) ua los ntawm cov khoom siv sib xyaw ua ke polyamide / aluminium ntawv ci / PVC-aluminium ntawv ci (Txias tsim OPA / Al / PVC-Al). 3 lossis 9 bl. (cov hlwv) muab tso rau hauv lub thawv ntawv thawv.

Cov ntsiav tshuaj-yeeb yaj kiab, 30 mg. 10 ntsiav tshuaj nyob rau hauv lub hlwv ntawm cov khoom sib txuas ua ke polyamide / aluminium / PVC-aluminium ntawv ci. 3 bl. (cov hlwv) muab tso rau hauv lub thawv ntawv thawv.

Cov ntsiav tshuaj-yeeb yaj kiab, 40 mg. 10 ntsiav tshuaj nyob rau hauv blister (blister sawb ntim) ua los ntawm cov khoom siv sib txuas polyamide / aluminium ntawv ci / PVC-aluminium ntawv ci. 3 bl. (cov hlwv) muab tso rau hauv lub thawv ntawv thawv.

Chaw tsim tshuaj paus

1. JSC “Krka, hnub, Novo mesto”. Marješka cesta 6, 8501 Qhov chaw tshiab, Slovenia.

2. LLC KRKA-RUS, 143500, Tebchaws Russia, Moscow Cheeb Tsam, Istra, ul. Moskovskaya, 50, nyob rau hauv kev koom tes nrog JSC "KRKA, hnub, Novo mesto", Šmarješka cesta 6, 8501 Novo mesto, Slovenia.

Xov Tooj: (495) 994-70-70, fev: (495) 994-70-78.

Thaum ntim khoom thiab / lossis ntim khoom ntawm Lavxias teb sab chaw ua lag luam, nws yuav tsum muaj kev sau npe: "KRKA-RUS" LLC. 143500, Russia, Moscow Cheeb Tsam, Istra, ul. Moscow, 50.

Xov Tooj: (495) 994-70-70, fev: (495) 994-70-78.

CJSC Vector-Medica, 630559, Russia, Novosibirsk cheeb tsam, cheeb tsam Novosibirsk, r.p. Koltsovo, lub tsev 13, lub tsev 15 15.

Tel./fax: (383) 363-32-96.

Tus sawv cev chaw ua haujlwm ntawm Krka, hnub, Novo mesto JSC hauv Lavxias Federation / koomhaum lees txais kev tsis txaus siab ntawm cov neeg siv khoom: 125212, Moscow, Golovinskoye sh., 5, bldg. 1, pem teb 22.

Tel.: (495) 981-10-88, fev (495) 981-10-90.

Tawm tswv yim

Atoris ® tsuas yog atorvastatin nkaus xwb uas muaj qhov pov thawj ua tau zoo raws li qhov ua tau zoo thiab kev nyab xeeb.

Hauv ntau cov kev tshawb fawb, cov ntaub ntawv hauv qab no tau txais.

Tshawb fawb INTER-ARS. Ib txoj kev sib piv thoob ntiaj teb ntawm Atoris ® (Krka) thiab tus thawj atorvastatin. Txoj kev tshawb no ntev li 16 lub lis piam thiab tau ua hauv 3 lub teb chaws (Slovenia, Poland thiab Czech koom pheej). Txoj kev tshawb no suav nrog 117 cov neeg mob uas randomized rau hauv ob pawg - ib pab pawg tau txais Atoris n (n = 57), lwm tus tau txais thawj atorvastatin (n = 60). Thaum lub sijhawm tiav ntawm cov kev tshawb fawb, qhov nruab nrab ntau npaum ntawm Atoris ® yog 16 mg. Txoj kev tshawb no tau lees tias kev kho mob kom sib npaug ntawm Atoris ® rau qhov qub atorvastatin hauv kev ua kom cov lipid spectrum zoo li qub. Atoris ® tseem pom tias muaj kev cuam tshuam zoo sib xws nrog thawj atorvastatin hauv kev txo cov C-reactive protein. Atomis profile thev kam rau siab tau piv nrog qhov kam rau ua qhov tseeb ntawm thawj atorvastatin.

Kev Tshawb Fawb ATLANTICA. Kev soj ntsuam cov txiaj ntsig ntawm kev ua haujlwm thiab kev nyab xeeb ntawm Atoris ® nyob rau hauv kev kho mob ntev ntev ntawm cov neeg mob dyslipidemia thiab qhov kev pheej hmoo ntau ntxiv ntawm kev txhim kho cov kab mob plawv. Txoj kev tshawb no suav nrog 655 tus neeg mob. Cov neeg mob tau randomized rau hauv peb pawg.

Cov neeg mob hauv pab pawg A (n = 216) tau txais Atoris ® ntawm kev noj tshuaj ntawm 10 mg, cov neeg mob hauv Pawg B (n = 207) tau txais Atoris ntawm koob tshuaj 10 mg txog 80 mg (qhov nruab nrab ntau kawg thaum kawg ntawm kev tshawb fawb yog 28.6 mg ), cov neeg mob nyob rau hauv pawg C (n = 209) tau txais kev kho raws qauv (kev hloov pauv hauv lub neej, kev hloov tshuaj muaj nrog kev kho lipid-txo qis).

Kev hloov pauv tseem ceeb hauv LDL-C (42% txo), OXc (30% txo), TG (24% tsawg dua) tom qab 24 lub lis piam raug pom hauv cov neeg mob tau txais kev kho mob ntau dua nrog atorvastatin (pab pawg B) piv nrog cov neeg mob uas tau txais Atoris ® hauv qhov ntau npaum 10 mg, thiab los ntawm cov neeg mob tau txais kev kho mob.Txoj kev tshawb no pom tias qhov ua tau zoo thiab kev nyab xeeb ntawm Atoris ® rau kev kho mob mus ntev ntawm cov neeg mob uas muaj dyslipidemia thiab muaj feem ntau ntawm cov kev mob plawv.

ATOP kawm. Kev soj ntsuam ntawm qhov ua tau zoo thiab kev nyab xeeb ntawm Atoris ® nyob rau hauv cov neeg mob loj (cov neeg mob ua mob rau cov hlab ntsha, cov mob ua pa, cov ntshav qab zib mellitus, obliterating kab mob ntawm cov tsis muaj hlab ntshav tawm). Lub sijhawm siv ntawm kev kawm yog 12 lub lis piam. Cov neeg mob (n = 334) tau txais Atoris ® hauv kev noj tshuaj los ntawm 10 txog 40 mg. Qhov nruab nrab txhua hnub ntau npaum li cas ntawm Atoris ® thaum xaus ntawm txoj kev tshawb no yog 21.3 mg. Txoj kev kho Atoris ® ua rau muaj qhov kev txo qis hauv LDL-C los ntawm 36% thiab OXc los ntawm 26%. Txoj kev tshawb no tau lees paub tias txoj kev kho ua kom zoo thiab muaj kev nyab xeeb zoo ntawm Atoris ® ntau pab pawg neeg mob.

Tshawb FARVATER. Kev soj ntsuam ntawm cov txiaj ntsig ntawm cov nyhuv ntawm cov tshuaj Atoris ® 10 thiab 20 mg rau qib ntawm lipids, C-reactive protein thiab fibrinogen hauv cov neeg mob uas muaj mob rau cov hlab ntshav liab thiab dyslipidemia. Txoj kev tshawb no suav nrog 50 cov neeg mob uas, tom qab xaiv nkag, tau txais Atoris ® kev noj tshuaj 10 lossis 20 mg / hnub. Kev siv cov tshuaj Atoris,, ob qho 10 thiab 20 mg / hnub rau 6 lub lis piam, tau nrog nrog qhov txo qis ntawm OXs, TG thiab Chs-LDL. Hauv pawg ntawm cov neeg mob tau txais 10 mg / hnub ntawm Atoris ®, qhov kev txo qis no yog 24.5% (OXc), 18.4% (TG), 34.9% (Chs-LDL), thiab hauv cov uas tau txais Atoris ® 20 mg / hnub - 29.1% (OXc), 28.2% (TG), 40.9% (LDL-C), feem. Tom qab 12 lub lim piam ntawm kev kho mob, ESA (endothelium-vas vasodilation) pom ntau ntxiv los ntawm 40.2% (10 mg / hnub) thiab 51.3% (20 mg / hnub). Vascular phab ntsa txhav txhav poob qis 23.4% (p = 0.008) thiab 25.7% (p = 0.002) hauv pawg 10 thiab 20 mg / hnub, ntsig txog. Txoj kev tshawb no pom tau tias qhov kev txo qis lipid zoo thiab cov teebmeem pleiotropic zoo rau cov neeg mob ua mob rau cov hlab ntshav ntawm lub cev thiab hyperlipidemia.

Kawm txog OSCAR. Kev tshuaj ntsuam xyuas ntawm qhov ua tau zoo thiab kev nyab xeeb ntawm Atoris ® hauv kev coj ua tiag tiag. Txoj kev tshawb no suav nrog 7098 cov neeg mob uas tau txais atka ntawm Krka lub tuam txhab - Atoris ® (10 mg / hnub). Tom qab 8 lub lis piam ntawm kev kho mob nrog Atoris ®, qib ntawm OXs poob qis los ntawm 22.7%, Chs-LDL - los ntawm 26.7% thiab TG - los ntawm 24%. Tag nrho cov kev pheej hmoo ntawm lub plawv poob qis los ntawm 33%. Txoj kev tshawb no tau qhia txog qhov ua tau zoo thiab kev nyab xeeb ntawm Atoris ® hauv kev coj ua tiag tiag.

1. Inter Ars. Cov ntaub ntawv ntawm cov ntawv, KRKA d.d., Novo mesto.

2. ATLANTICA (Kev ua tau zoo thiab kev nyab xeeb ntawm Atoris (atorvastatin, KRKA) thiab nws cov txiaj ntsig ntawm kev pheej hmoo ntawm cov hlab ntshav tshwm sim hauv cov neeg mob hyperlipidemia) - Belenkov Yu.N., Oganov R.G. Chav Dispensary Kev Tshawb Fawb ntawm Lub Tsev Kawm Ntawv ntawm Cardiology lub npe tom qab A.L. Myasnikova.- FGU RKNPK Rosmedtekhnologii.// Cardiology.- №11.- 2008.

3. ATOP. Cov ntaub ntawv ntawm cov ntawv, KRKA d.d., Novo mesto.

4. FARVATER (Ua tau zoo ntawm Atorvastatin rau ntawm cov leeg ntshav ntsa thiab CRP) - A. Susekov, V. Kukharchuk.- FGU RKNPK Ministry of Health ntawm Lavxias Federation thiab SR Moscow.- 2006.- Cardiology.- No. 9.- 06.- P.4-9 Cov.

5. Shalnova SA, Deev AD Zaj lus qhia los ntawm OSCAR txoj kev tshawb nrhiav - Kev kis mob thiab kev kho mob ntawm cov neeg muaj mob pheej hmoo ntau rau cov kev soj ntsuam mob tiag tiag 2005-2006 // Kev kho mob plawv thiab kev tiv thaiv .- 2007.- 6 (1).

Homozygous muaj keeb tiv thaiv hypercholesterolemia

Cov koob tshuaj ntau yog tib yam li nrog lwm hom hyperlipidemia.

Thawj koob tshuaj tau xaiv ib tus zuj zus nyob ntawm qhov mob hnyav ntawm tus kab mob. Hauv feem ntau cov neeg mob homozygous kab mob hypercholesterolemia, cov txiaj ntsig zoo tshaj plaws yog pom nrog kev siv tshuaj hauv ib hnub ntawm 80 mg (ib zaug). Atoris® yog siv los ua kev kho rau lwm txoj hau kev kho mob (plasmapheresis) los yog kev kho mob tseem ceeb yog tias kev kho nrog lwm txoj kev tsis tuaj yeem ua.

Siv rau cov laus

Hauv cov neeg laus laus thiab cov neeg mob raum, cov tshuaj Atoris yuav tsum tsis txhob hloov pauv. Lub raum ua haujlwm tsis zoo cuam tshuam rau qhov kev txiav txim ntawm atorvastatin nyob rau hauv cov ntshav ntshav lossis qhov qis ntawm qhov txo qis hauv cov concentration ntawm LDL-C nrog kev siv atorvastatin, yog li ntawd, hloov cov koob tshuaj tsis tas yuav tsum.

Lub siab ua haujlwm tsis zoo

Hauv cov neeg mob uas muaj lub siab ua haujlwm tsis zoo, kev ceev faj yog qhov tsim nyog (vim kev ua haujlwm qeeb hauv kev tshem tawm cov tshuaj tawm hauv lub cev). Thaum muaj qhov xwm txheej zoo li no, cov chaw kuaj mob thiab kuaj ntsuas yuav tsum tau ua tib zoo saib xyuas (kev saib xyuas tsis tu ncua ntawm kev ua ntawm aspartate aminotransferase (ACT) thiab alanine aminotransferase (ALT)). Nrog txoj kev nce siab ntxiv hauv cov haujlwm ntawm hepatic transaminases, koob tshuaj Atoris yuav tsum tau txo lossis txoj kev kho yuav tsum tau txiav tawm.

Siv thaum cev xeeb tub thiab lactation

Atoris yog contraindicated rau hauv kev xeeb tub thiab lub sijhawm pub mis. Kev tshawb fawb tsiaj qhia tias kev pheej hmoo rau tus me nyuam hauv plab yuav dhau qhov txiaj ntsig tau rau leej niam.

Hauv cov poj niam ntawm kev ua me nyuam hnub nyoog uas tsis siv txoj hauv kev tiv thaiv kom muaj txiaj ntsig, kev siv Atoris tsis pom zoo. Thaum npaj kev cev xeeb tub, koj yuav tsum tsum tsis siv Atoris tsawg kawg 1 hlis ua ntej koj npaj cev xeeb tub.

Tsis muaj pov thawj ntawm kev faib cov atorvastatin nrog rau niam mis. Txawm li cas los xij, hauv qee hom tsiaj, qhov kev nkag siab ntawm atorvastatin hauv cov ntshav cov ntshav thiab hauv cov mis ntawm lactating tsiaj yog qhov zoo sib xws. Yog tias yuav tsum tau siv cov tshuaj Atoris thaum lactation, txhawm rau kom tsis txhob muaj kev pheej hmoo ntawm kev tshwm sim tsis zoo hauv cov menyuam mos, kev pub mis niam yuav tsum tau tsum.

Yeeb tshuaj sib cuam tshuam

Nrog tib lub sijhawm siv Atoris nrog diltiazem, ib qho kev nce siab ntawm Atoris hauv cov ntshav ntshav kuj yuav pom.

Txoj kev pheej hmoo ntawm cov teeb meem ntau ntxiv thaum Atoris yog siv ua ke nrog fibrates, nicotinic acid, tshuaj tua kab mob, cov tshuaj tua kab mob.

Qhov ua tau zoo ntawm Atoris txo qis nrog kev siv tib lub sijhawm ntawm Rifampicin thiab Phenytoin.

Nrog rau kev siv ib txhij nrog kev npaj tshuaj antacid, uas suav nrog aluminium thiab magnesium, qhov kev txo qis ntawm Atoris hauv cov ntshav ntshav yog pom.

Kev noj cov tshuaj Atoris ua ke nrog kua txiv kab ntxwv qaub tuaj yeem ua rau muaj kev saib xyuas ntau ntxiv ntawm cov tshuaj hauv ntshav ntshav. Cov neeg mob uas noj tshuaj Atoris yuav tsum nco ntsoov tias haus kua txiv kab ntxwv qaub rau hauv ib lub ntim ntau dua li 1 ລິດ hauv ib hnub yog qhov tsis lees txais.