Metfogamma® 850 (Metfogamma® 850)

Muaj ib ntsiav tshuaj:

Cov tshuaj nquag: metformin hydrochloride - 850 mg.

Cov muaj mob siab: hypromellose, povidone, magnesium stearate.

Lub plhaub muaj pes tsawg leeg: hypromellose, macrogol 6000, titanium dioxide (E 171).

Ntev cov ntsiav tshuaj dawb, zaj duab xis-txheej, nrog cov kab ua txhaum ntawm ob sab, yuav luag tsw.

Pharmacological kev txiav txim

Metphogamma 850 yog ib qhov ncauj tshuaj hypoglycemic los ntawm pab pawg biguanide. Nws inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm txoj hnyuv, txhim kho kev siv ntawm cov kua nplaum ntev, thiab tseem ua rau kev nkag siab ntawm cov ntaub so ntswg mus rau insulin. Txawm li cas los xij, nws tsis muaj kev cuam tshuam cov kua dej los ntawm cov kua hlwb ntawm lub cev ua kua txiav. Txo cov theem ntawm triglycerides thiab qis lipoproteins ntau hauv cov ntshav. Stabilizes lossis txo qhov hnyav lub cev. Nws muaj cov nyhuv fibrinolytic vim yog kev tsuj tawm ntawm cov nqaij plasminogen activator inhibitor.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, cov tshuaj no yog nqus hauv plab nyhuv. Bioavailability tom qab noj cov koob tshuaj yog -50-60%. Qhov siab tshaj plaws hauv cov ntshav ntshav tau mus txog 2 teev tom qab noj. Nws xyaum tsis khi rau cov plasma protein. Nws accumulates nyob rau hauv salivary qog, mob siab thiab ob lub raum. Nws yog tawm tawm tsis hloov pauv los ntawm ob lub raum. Ib nrab-lub neej yog 1.5-4.5 teev.

Nrog kev ua haujlwm tsis zoo hauv lub raum, tsub zuj zuj ntawm cov tshuaj yog ua tau.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm Metfogamma 850 tau teeb tsa ib leeg zuj zus, suav txog qib li ntawm cov piam thaj hauv cov ntshav. Thawj koob tshuaj feem ntau yog 850 mg (1 ntsiav tshuaj) ib hnub, ib qho kev nce ntxiv ntawm koob tshuaj yog ua tau raws li cov txiaj ntsig ntawm txoj kev kho. Kev saib xyuas cov tshuaj ntawm cov tshuaj yog 850-1700 mg (1-2 ntsiav tshuaj) ib hnub. Qhov siab tshaj plaws txhua hnub yog 1700 mg (2 ntsiav tshuaj), kev teem sijhawm siab dua tsis ua rau muaj txiaj ntsig ntawm kev kho mob.

Qhov koob tshuaj txhua hnub ntau dua 850 mg yog pom zoo nyob rau hauv ob lub tshuaj (thaum sawv ntxov thiab yav tsaus ntuj). Hauv cov neeg mob laus, cov koob tshuaj pom zoo txhua hnub yuav tsum tsis pub tshaj 850 mg.

Metphogamma 850 ntsiav tshuaj yuav tsum tau noj nrog zaub mov, tag nrho, ntxuav cia nrog ib qho me me ntawm kua (ib khob dej). Lub chav kawm ntawm kev kho mob nrog cov tshuaj yeeb tshuaj ntev.

Sab sij huam

Los ntawm qhov mob plab zom mov: xeev siab, ntuav, mob plab, raws plab, tsis qab los noj mov, “nws yog xim hlau” hauv qhov ncauj. Hauv cov rooj plaub no, kev kho tsis tu ncua feem ntau tsis tas yuav tsum muaj, thiab cov tsos mob daws tau lawv tus kheej yam tsis tau hloov koob tshuaj. Qhov ntau zaus thiab qhov mob tshwm sim ntawm qhov mob tshwm sim ntawm txoj hnyuv tuaj yeem txo qis nrog kev nce mentsis ntawm cov tshuaj metformin.

Kev ua xua rau: xoo pob khaus.

Los ntawm cov kab mob endocrine: hypoglycemia (feem ntau yog siv thaum tsis txaus noj).

Kev tiv thaiv kabmob (Metabolism): nyob rau qee qhov tsawg, muaj cov kab mob lactic acidosis (xav kom tsis muaj kev kho mob).

Los ntawm cov kab mob hemopoietic: qee kis - megaloblastic anemia.

Noj ntau dhau

Nrog kev noj haus ntau tshaj ntawm Metfogamma 850, cov kab mob lactic acidosis nrog rau kev ua kom neeg mob taus yog ua tau. Qhov ua rau kev txhim kho ntawm cov kab mob lactic acid tuaj yeem tseem yog kev ruaj khov ntawm cov tshuaj vim tias lub zog ua haujlwm tsis zoo. Cov tsos mob thaum ntxov ntawm tus kab mob lactic acid yog xeev siab, ntuav, raws plab, kub ib ce, mob plab, mob leeg, ces yuav muaj kev ua pa ntau ntxiv, kiv taub hau, tsis nco qab zoo thiab kev loj hlob ntawm coma. mus pw hauv tsev kho mob kom sai thiab, tau txiav txim siab qhov concentration ntawm lactate, paub meej tias txoj kev kuaj mob. Qhov ua tau zoo tshaj plaws los tshem tawm lactate thiab Metphogamma 850 los ntawm lub cev yog hemodialysis. Cov kev mob tshwm sim kuj yog nqa tawm. Nrog cov kev sib txuas ua ke ntawm Metphogamma 850 nrog sulfonylurea kev npaj, hypoglycemia yuav loj hlob tuaj.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog tib lub sijhawm siv nrog sulfonylurea derivatives, acarbose, insulin, tshuaj tsis-steroidal anti-inflammatory tshuaj, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, B-blockers, nws yog qhov muaj peev xwm nce hypoglycemic nyhuv ntawm metformin. Nrog rau kev siv ua ke nrog glucocorticosteroids, tshuaj tiv thaiv qhov ncauj, epinephrine, sympathomimetics, glucagon, cov thyroid hormones, thiazide thiab "voj" diuretics, phenothiazine derivatives, nicotinic acid derivatives, nws yog qhov ua tau kom txo cov nyhuv hypoglycemic ntawm metformin.

Cimetidine qeeb qeeb ntawm kev txiav tawm cov metformin, uas ua rau muaj kev pheej hmoo ntawm lactic acidosis.

Metformin tej zaum yuav ua rau cov tshuaj anticoagulants tsis muaj zog (coumarin derivatives). Nrog rau kev haus cawv ib txhij, lactic acidosis yuav pib mob.

Daim ntawv thov nta

Nws tsis pom zoo rau mob hnyav, dhau mus ua kab mob sib kis thiab mob o, raug mob, mob phais mob hnyav, thaum kho mob insulin. Tsis txhob siv ua ntej kev phais thiab tsis pub dhau 2 hnub tom qab lawv tau ua.

Kev siv Metfogamma 850 tsis pom zoo siv tsawg kawg 2 hnub ua ntej thiab 2 hnub tom qab xoo hluav taws xob los yog xoo hluav taws xob los ntawm kev siv tshuaj tiv thaiv. Nws tsis pom zoo kom siv cov tshuaj hauv cov neeg mob rau ntawm kev noj zaub mov nrog kev txwv hauv caloric kom tsawg (

Nosological kev faib tawm (ICD-10)

Cov Tshuaj Hauv Tshuaj

Nws inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm txoj hnyuv, txhim kho kev siv ntawm cov kua nplaum ntev, thiab ua rau muaj kev cuam tshuam ntawm cov ntaub so ntswg mus rau insulin. Txo cov theem ntawm triglycerides thiab qis lipoproteins ntau hauv cov ntshav. Nws muaj cov nyhuv fibrinolytic (tiv thaiv kev ua haujlwm ntawm cov nqaij-plasminogen activator inhibitor), ua kom lub zog lossis txo qhov hnyav ntawm lub cev.

Cov Yuav Tsum Tau Ua

ketoacidosis, mob ntshav qab zib precoma thiab coma,

mob raum thiab mob rau lub siab,

lub plawv thiab ua pa tsis ua haujlwm,

mob theem ntawm myocardial infarction,

cov kev huam yuaj ntawm cerebrovascular,

lactic acidosis thiab kev qhia ntawm nws hauv keeb kwm, tej yam xwm txheej uas yuav pab txhawb kev txhim kho ntawm cov kab mob lactic acidosis, suav nrog haus cawv ntev,

Sab sij huam

Los ntawm cov hlab plawv system thiab ntshav (hematopoiesis, hemostasis): Qee qhov megaloblastic anemia.

Los ntawm cov hnyuv: xeev siab, ntuav, mob plab, raws plab, tsis qab los noj mov, yog xim hlau hauv qhov ncauj.

Los ntawm sab ntawm cov metabolism: hypoglycemia, tsis tshua muaj mob, cov kab mob lactic acidosis (yuav tsum muaj kev tso tshuaj kho mob).

Kev tsis haum tshuaj: daim tawv nqaij ua pob.

Cov lus qhia tshwj xeeb

Nws tsis pom zoo rau cov kab mob kis mob siab lossis kis hnyav ntawm tus kab mob sib kis thiab mob, kev raug mob, mob kab mob sai, ua ntej kev phais mob thiab hauv 2 hnub tom qab lawv tau ua tiav, nrog rau 2 hnub ua ntej thiab tom qab kuaj mob (radiological thiab radiological) kev siv ntawm cov ntawv xov xwm sib piv). Nws yuav tsum tsis txhob siv rau hauv cov neeg mob ntawm kev noj zaub mov nrog cov kev txwv ntawm lub caloric kom tsawg (tsawg dua 1000 kcal / hnub). Kev siv cov tshuaj tsis pom zoo rau cov neeg muaj hnub nyoog 60 xyoo uas ua haujlwm lub cev hnyav (vim tias qhov pheej hmoo ntawm kev tsim mob lactic acidosis).

Cuam Tshuam rau kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog tshuab. Tsis muaj cov nyhuv (thaum siv los ua kev kho mob monotherapy). Ua ke nrog lwm tus kab mob hypoglycemic (sulfonylurea derivatives, insulin, thiab lwm yam), kev txhim kho hypoglycemic lub xeev yog muaj peev xwm, nyob rau hauv uas muaj peev xwm tsav tsheb thiab koom nrog lwm yam kev muaj feem phom sij uas xav tau kev nce siab thiab ceev ntawm psychomotor cov kev tsis taus.

Chaw tsim tshuaj paus

Werwag Pharma GmbH & Co. KG, Kalverstrasse 7, 71034, Beblingen, Lub Tebchaws Yelemees.

Chaw tsim tshuaj paus: Artesan Pharma GmbH & Co. KG, Wendlandstrasse, 1, 29439, Lyukhov, Lub Tebchaws Yelemees.

Kev Tshawb Fawb Ntsej Muag Apkker Püschl GmbH & Co. KG, Gellstrasse, 1, 84529, Tittmoning, Lub Tebchaws Yelemees.

CJSC ZiO-Zdorovye, Russia, 142103, Cheeb Tsam Moscow, Podolsk, ul. Kev tsheb ciav hlau, 2.

Tus sawv cev chaw haujlwm / lub koomhaum lees txais cov lus thov: lub chaw sawv cev ntawm lub tuam txhab Vervag Pharma GmbH & Co. CG nyob rau hauv Lavxias Federation.

117587, Moscow, Warsaw txoj kev loj, 125 F, bldg. 6.

Tel.: (495) 382-85-56.

Dosage daim ntawv

Cov ntsiav tshuaj ua yeeb yaj kiab, 850 mg

Ib ntsiav tshuaj muaj

cov tshuaj nquag - metformin hydrochloride 850 mg

(sib npaug rau metformin 662,8 mg),

tus zam: hypromellose (15000 mPas), Povidone K25, magnesium stearate,

muaj pes tsawg leeg muaj pes tsawg leeg: hypromellose (5mPas), macrogol 6000, titanium dioxide (E171).

Cov ntsiav tshuaj uas ntev dua nrog lub ntsej muag biconvex, npog nrog cov txheej zaj duab xis dawb, nrog kev pheej hmoo ntawm ob sab, taub (7.5 ± 0.5 x 21.5 ± 0.5) hli thiab ntev (6.0 ± 6.8) hli.

Cov chaw muag tshuaj

Tom qab kev tswj hwm ntawm qhov ncauj, metformin yog nqus los ntawm txoj hnyuv hauv plab. Bioavailability tom qab noj cov qauv tshuaj yog 50-60%. Qhov siab tshaj plaws ntshav plasma concentration Cmax tau mus txog 2.5 teev tom qab noj. Nws xyaum tsis khi rau cov plasma protein. Nws accumulates nyob rau hauv salivary qog, nqaij, mob siab thiab ob lub raum. Metformin thauj mus los rau cov ntshav liab; cov qe ntshav liab yog qhov chaw faib khoom seem. Nws yog tawm tawm tsis hloov pauv los ntawm ob lub raum. Ib nrab-lub neej yog 6,5 teev .Txhob tsis ua haujlwm rau lub raum lub ntsej muag, lub zog ruaj khov ntawm cov tshuaj muaj peev xwm ua tau. Nws xav tias qhov pharmacokinetics ntawm metformin adsorption tsis yog kab.

Metfogamma® 850 inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm cov hnyuv, txhim kho kev siv peripheral ntawm cov piam thaj, thiab tseem ua rau kev nkag siab ntawm cov ntaub so ntswg rau insulin. Metformin stimulates intracellular glycogen synthesis los ntawm kev ua ntawm glycogen synthase, muaj peev xwm thauj ntau ntxiv ntawm txhua yam ntawm cov protein membrane cov khoom thauj. Txawm li cas los xij, nws tsis muaj kev cuam tshuam cov kua dej los ntawm cov kua hlwb ntawm lub cev ua kua txiav. Txo cov roj (cholesterol) tag nrho, triglycerides thiab qis lipoproteins tsawg hauv cov ntshav. Stabilizes lossis txo qhov hnyav lub cev. Nws muaj cov nyhuv fibrinolytic vim yog kev tsuj tawm ntawm cov nqaij plasminogen activator inhibitor.

Daim ntawv tso tawm, ntim thiab muaj pes tsawg leeg Metfogamma ® 850

Cov ntsiav tshuaj, coated nrog cov xim zaj duab xis txheej, yog oblong, nrog kev pheej hmoo, nrog yuav luag tsis muaj ntxhiab tsw.

Tshwjxeeb: hypromellose (1500CPS), hypromellose (5CPS), povidone (K25), magnesium stearate, macrogol 6000, titanium dioxide.

10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs - hlwv (6) - pob khoom los ntawm cardboard.
10 Pcs - hlwv (12) - pob khoom los ntawm cardboard.
20 Pcs. - hlwv (6) - pob khoom los ntawm cardboard.

Kev noj tshuaj ntxiv

Teeb ntawm tus kheej, noj mus rau hauv tus account theem ntawm cov piam thaj hauv cov ntshav.

Qhov kev muab tshuaj thawj zaug feem ntau yog 850 mg (1 tab.) / Hnub. Ib qho kev nce zuj zus ntxiv hauv koob tshuaj yog muaj peev xwm ua raws li cov txiaj ntsig ntawm kev kho mob. Cov koob tshuaj saib xyuas yog 850-1700 mg (1-2 ntsiav tshuaj) / hnub. Qhov siab tshuaj ntau tshaj txhua hnub yog 2550 mg (3 ntsiav tshuaj).

Qhov koob tshuaj txhua hnub ntau dua 850 mg yog pom zoo hauv 2 faib koob tshuaj (sawv ntxov thiab yav tsaus ntuj).

Hauv cov neeg mob laus, cov koob tshuaj pom zoo yuav tsum tsis pub tshaj 850 mg / hnub.

Cov ntsiav tshuaj yuav tsum tau noj nrog zaub mov ua ke, ntxhua nrog ib qho me me ntawm cov kua (ib khob dej).

Cov tshuaj yog npaj rau kev siv sijhawm ntev.

Vim tias qhov pheej hmoo ntawm cov kab mob lactic acidosis, nyob rau hauv cov teeb meem hauv lub cev hnyav ntawm lub cev, cov tshuaj yuav tsum raug txo kom tsawg.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv tib lub sijhawm nrog sulfonylurea derivatives, acarbose, insulin, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide thiab beta-blockers, nws yog qhov muaj peev xwm nce hypoglycemic effect ntawm metformin.

Nrog rau kev siv tib lub sijhawm nrog GCS, qhov ncauj tawm tsam, epinephrine (adrenaline), sympathomimetics, glucagon, cov thyroid hormones, thiazide thiab loopback diuretics, phenothiazine derivatives thiab nicotinic acid, qhov txo qis hauv cov nyhuv hypoglycemic ntawm metformin yog ua tau.

Cimetidine qeeb qeeb ntawm kev txiav tawm cov tshuaj metformin, vim tias qhov kev pheej hmoo ntawm lactic acidosis nce ntxiv.

Metformin tej zaum yuav ua rau cov tshuaj anticoagulants tsis muaj zog (coumarin derivatives).

Nrog rau kev tswj hwm ua ke nrog ethanol, txoj kev txhim kho ntawm cov kab mob lactic acidosis yog ua tau.

Nrog rau kev siv nifedipine tib lub sij hawm nce nqus ntawm metformin, C max, maj mam nqes los yog qhov tsis pom.

Cov tshuaj Cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) zais cia rau hauv cov menyuam ua lag luam sib tw rau tubular thauj tshuab thiab, nrog kev kho mob ntev, tuaj yeem nce C max metformin los ntawm 60%.

Kev ntsuas rau siv

- kev kho mob ntawm hom 2 mob ntshav qab zib mellitus rau cov neeg laus, tshwj xeeb hauv cov neeg mob rog, yog tias kev noj haus thiab kev ua si lub cev tsis muaj kev tswj glycemic txaus,

raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm cov tshuaj tiv thaiv kab mob hauv qhov ncauj, lossis nrog insulin

Cov tshuaj sib cuam tshuam

Kev sib xyaw uas tsis pom zoo.

Kev haus dej cawv ua rau muaj kev phom sij ntau ntxiv, tshwj xeeb yog cov mob hauv qab no:

- tshaib plab los yog tsis zoo noj,

Nws yog ib qho tsim nyog kom tsis txhob siv cawv thiab muaj dej cawv muaj tshuaj nyob hauv kev kho mob ntawm metformin.

Iodine-muaj cov tshuaj tiv thaiv sib thooj

Kev siv cov tshuaj iodine uas muaj cov tshuaj tiv thaiv tsis zoo tuaj yeem ua rau lub raum tsis ua hauj lwm, ua rau muaj qhov mus txuam nrog metformin, thiab muaj kev pheej hmoo ntxiv ntawm cov kab mob lactic acidosis. Kev siv cov metformin yuav tsum tau txiav ua ntej siv cov tshuaj zoo li no, thaum kawm nrog lawv siv thiab tsis pub dhau 48 teev tom qab lawv ua tiav. Txoj kev kho yuav tsum tau txuas ntxiv 48 teev tom qab qhov kawg ntawm kev kawm thiab tsuas yog tom qab kev tshuaj ntsuam xyuas thib ob ntawm lub raum ua haujlwm thiab ib qho tshwm sim ib txwm muaj.

Kev sib xyaw ua ke uas xav tau kev tshwj xeeb thaum siv

Cov tshuaj noj nrog lawv cov kev ua hauv lub cev hyperglycemic, piv txwv li, glucocorticoids (rau kev siv nruab zog thiab hauv nroog), beta-2 agonists, sympathomimetics.

Cov neeg mob yuav tsum tau qhia paub txog qhov no, qhia lawv pom tias yuav tsum saib xyuas cov ntshav qabzib ntau dua, tshwj xeeb tshaj yog nyob rau theem pib kho. Yog tias tsim nyog, cov tshuaj ntawm metformin thaum kho yuav tsum tswj hwm, tshwj xeeb tshaj yog thaum siv lwm yam tshuaj thiab tom qab siv nws txoj kev siv.

Diuretics, tshwj xeeb tshaj yog voj diuretics.

Txij li thaum muaj kev pheej hmoo siab ntawm kev ua tsis zoo rau lub raum muaj nuj nqi, muaj qhov pheej hmoo ntawm kev tsim mob lactic acidosis.

ACE cov tshuaj tiv thaiv kab mob tuaj yeem ua rau txo cov ntshav piam thaj kom tsawg. Yog tias tsim nyog, qhov tshuaj ntawm cov tshuaj hypoglycemic yuav tsum tau kho thaum kho siv ACE inhibitors thiab tom qab tsis ua tiav ntawm qhov kev kho no.