Lozap 50 mg - cov lus qhia rau kev siv > Kev khomob thiab kev tiv thaiv

50 mg zaj duab xis-coated ntsiav tshuaj

Ib ntsiav tshuaj muaj

cov tshuaj nquag - losartan poov tshuaj 50 mg,
kev zam: mannitol - 50.00 mg, microcrystalline cellulose - 80.00 mg, crospovidone - 10.00 mg, anhydrous colloidal silicon dioxide - 2.00 mg, talc - 4.00 mg, magnesium stearate - 4.00 mg,
Sepifilm 752 lub plhaub muaj pes tsawg leeg: hydroxypropyl methylcellulose, microcrystalline cellulose, macrogol stearate 2000, titanium dioxide (E171), macrogol 6000

Zoo li lub ntsej muag ntsiav tshuaj, biconvex, halved, coated nrog zaj duab xis daim nyias nyias ntawm cov xim dawb lossis yuav luag dawb, muaj kwv yees 11.0 x 5.5 hli loj

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, losartan yog qhov zoo los ntawm txoj hnyuv plab hnyuv (GIT) thiab yauv ua lub cev cov kab mob presystemic nrog kev tsim cov carboxyl metabolite thiab lwm cov tshuaj tiv thaiv. Cov kab ke ua haujlwm ntawm lub cev muaj peev xwm ntawm losartan hauv cov qauv tshuaj yog kwv yees li 33%. Qhov nruab nrab ntau ntau ntawm losartan thiab nws cov metabolite nquag tau mus txog tom qab 1 teev thiab 3 mus rau 4 teev, feem.

Biotransformation

Li ntawm 14% ntawm losartan, thaum muab cov lus ntawm ncauj, hloov pauv mus ua ib qho metabolite. Ntxiv nrog rau lub cev zom cov khoom noj tshwj xeeb, cov pib ua kom lub cev ntaj ntsug kuj tseem raug tsim.

Lub plasma tshem ntawm losartan thiab nws cov metabolite yog 600 ml / feeb thiab 50 ml / feeb, feem. Lub raum tshem tawm ntawm losartan thiab nws cov metabolite nquag muaj kwv yees li ntawm 74 ml / feeb thiab 26 ml / feeb, feem. Nrog rau kev tswj hwm ntawm qhov ncauj ntawm losartan, kwv yees li 4% ntawm cov koob tshuaj tau pom tias tsis hloov pauv hauv cov zis, thiab kwv yees li 6% ntawm cov tshuaj tau tawm hauv cov zis los ua cov metabolite. Lub chaw muag tshuaj ntawm losartan thiab nws cov tshuaj metabolite yog txig nrog kev tswj hwm ntawm losartan potassium hauv koob tshuaj txog 200 mg.

Tom qab kev tswj hwm ntawm qhov ncauj, qhov ntau ntawm losartan thiab nws cov metabolite nquag txo qis tshaj tawm nrog qhov kawg ntawm lub neej ib nrab ntawm kwv yees li 2 teev thiab 6 txog 9 teev, feem. Thaum siv ib zaug ib hnub ntawm koob tshuaj 100 mg, tsis muaj qhov tshaj tawm los ntawm losartan thiab nws cov nquag metabolite hauv cov ntshav ntshav.

Losartan thiab nws cov metabolite nquag ua rau cov kua tsib thiab tso zis. Tom qab cov neeg siv qhov ncauj, kwv yees li 35% thiab 43% yog cov zis tawm, thiab 58% thiab 50% nrog quav, feem.

Mechanism ntawm kev ua

Losartan yog hluavtaws angiotensin II receptor antagonist (hom AT1) rau kev siv lub qhov ncauj. Angiotensin II - muaj zog vasoconstrictor - yog ib yam tshuaj lom ntawm lub cev renin-angiotensin thiab yog ib qho tseem ceeb tshaj plaws hauv pathophysiology ntawm kev mob ntshav siab. Angiotensin II khi rau AT1 receptors, uas yog nyob hauv cov leeg leeg ntawm cov hlab ntshav, hauv cov qog adrenal, hauv lub raum thiab hauv plawv), txiav txim siab txog ntau cov teebmeem kev lom neeg, suav nrog vasoconstriction thiab tso tawm aldosterone. Angiotensin II tseem muaj kev cuam tshuam cov kev loj hlob ntawm cov leeg hlwb muaj zog.

Losartan xaiv cov nplov AT1 receptors. Losartan thiab nws cov tshuaj pharmacologically nquag metabolite - carboxylic acid (E-3174) thaiv hauv vitro thiab hauv vivo txhua qhov teeb meem ntawm lub cev ntawm angiotensin II, tsis hais txog lub hauv paus chiv keeb thiab txoj kev coj los ua ke.

Losartan tsis muaj qhov ua kom ntxim ntxub thiab tsis thaiv lwm yam tshuaj receptors lossis ion channels uas tau koom nrog kev tswj hwm ntawm cov kab mob plawv. Ntxiv mus, losartan tsis inhibit ACE (kininase II), ib qho enzyme uas txhawb txoj kev puas tsuaj ntawm bradykinin. Raws li qhov tshwm sim ntawm qhov no, kev muaj hwj chim tsis pom rau qhov tshwm sim ntawm cov kev mob tshwm sim los ntawm kev sib kho bradykinin.

Thaum lub sijhawm siv losartan, kev tshem tawm ntawm qhov tshwm sim tsis zoo rov qab ntawm angiotensin II rau kev tso tawm cov lus zais ua rau muaj kev nce plasma renin ntau ntxiv (ARP). Xws li kev nce qib hauv kev ua si ua rau kev nce qib ntawm angiotensin II hauv ntshav ntshav. Dua li ntawm qhov nce no, kev ua haujlwm ntawm antihypertensive thiab txo qis hauv kev mloog zoo ntawm aldosterone hauv cov ntshav plasma mob siab, uas qhia tau tias muaj kev cuam tshuam zoo ntawm cov tshuaj angiotensin II. Tom qab kev txiav tsis ua losartan, plasma renin kev ua si thiab qib angiotensin II tsis pub dhau 3 hnub rov qab mus rau qhov pib.

Ob leeg losartan thiab nws cov metabolite tseem ceeb muaj qhov zoo dua rau AT1 receptors dua li AT2. Lub cev nquag metabolite yog 10 txog 40 zaug ntau dua li losartan (thaum hloov ua huab hwm coj).

Lozap txo tag nrho peripheral vascular tsis kam (OPSS), qhov concentration ntawm adrenaline thiab aldosterone nyob rau hauv cov ntshav, ntshav siab, ntshav siab ntawm cov hlab ntsws, txo cov haujlwm tom qab, muaj cov nyhuv diuretic. Lozap tiv thaiv kev txhim kho ntawm myocardial hypertrophy, nce kev qoj ib ce ua siab ntev rau cov neeg mob plawv tsis ua haujlwm. Tom qab siv ib zaug ntawm Lozap, cov txiaj ntsig antihypertensive (txo qis hauv systolic thiab diastolic ntshav siab) nce mus txog qhov siab kawg nkaus tom qab 6 teev, tom qab ntawd maj mam txo qis hauv 24 teev. Qhov siab tshaj plaws antihypertensive nyhuv tiav 3-6 lub lis piam tom qab pib noj Lozap.

Cov ntaub ntawv pharmacological qhia tau hais tias qhov ntau ntawm losartan nyob rau hauv cov ntshav plasma hauv cov neeg mob uas muaj ntshav siab ntau zuj zus.

Kev ntsuas rau siv

Kev qhia rau kev siv tshuaj yog:

kev kho mob tawg tshwj xeeb rau cov neeg laus
kho kab mob hauv lub raum hauv cov neeg laus cov neeg mob ntshav liab thiab hom II mob ntshav qab zib mellitus nrog proteinuria ≥0.5 g / hnub ua ib feem ntawm antihypertensive kho
kev tiv thaiv ntawm kev txhim kho cov hlab plawv muaj teeb meem, suav nrog mob hlab ntsha tawg hauv cov neeg mob ntshav liab thiab sab laug ventricular hypertrophy, paub tseeb los ntawm kev tshawb nrhiav ECG
mob plawv tsis ua hauj lwm (raws li ib feem ntawm txoj kev kho ua ke, nrog
thev tsis tau lossis qhov tsis muaj txiaj ntsig ntawm kev kho nrog ACE inhibitors)

Tsuas tshuaj thiab tswj hwm

Lozap noj qhov ncauj, tsis hais txog ntawm cov pluas noj, qhov ntau zaus ntawm kev tswj hwm - 1 zaug hauv ib hnub.

Nrog rau cov roj ntsha tseem ceeb hauv cov ntshav, qhov nruab nrab txhua hnub koob tshuaj yog 50 mg ib hnub ib zaug. Qhov siab tshaj plaws antihypertensive nyhuv tiav 3-6 lub lis piam tom qab pib ntawm kev kho mob. Hauv qee tus neeg mob, ntxiv cov koob rau 100 mg ib hnub twg (thaum sawv ntxov) tej zaum yuav pab tau zoo dua.

Lozap tuaj yeem kho nrog lwm cov tshuaj tiv thaiv kev tiv thaiv, tshwj xeeb nrog tshuaj diuretics (piv txwv li, hydrochlorothiazide).

Cov neeg mob uas kub siab thiab hom II mob ntshav qab zib mellitus (proteinuria ≥0.5 g / hnub)

Qhov kev pib noj ib txwm ib txwm yog 50 mg ib hnub ib zaug. Qhov koob tshuaj tuaj yeem nce ntxiv txog 100 mg ib hnub ib zaug, nyob ntawm qhov ntsuas ntawm ntshav siab ib hlis tom qab pib kev kho mob. Lozap tuaj yeem siv nrog lwm cov tshuaj tiv thaiv kabmob (piv txwv li, diuretics, calcium channel blockers, alpha lossis beta receptor blockers, hauv nruab nrab cov tshuaj ua yeeb yaj kiab), nrog rau cov tshuaj insulin thiab lwm cov tshuaj feem ntau hypoglycemic (xws li sulfonylurea, glitazone thiab glucosidase inhibitors).

Lub plawv tsis ua hauj lwm ntau npaum

Thawj koob tshuaj ntawm losartan yog 12,5 mg ib hnub ib zaug. Feem ntau, koob tshuaj yog suav sau nyob rau ntawm ntu ib lis piam (xws li 12,5 mg ib hnub ib zaug. 25 mg ib hnub ib zaug. 50 mg ib hnub ib zaug, 100 mg ib hnub ib zaug) rau kev saib xyuas ib txwm muaj li 50 mg ib zaug ib hnub ib zaug nyob ntawm saib tus neeg mob lub siab ntev.

Txo txoj kev pheej hmoo ntawm mob hlab ntsha hauv cov neeg mob ntshav siab thiab tawm ntshav tawm tuaj ntawm ventricular hypertrophy, tau lees paub los ntawm ECG

Qhov kev pib noj ib txwm ib txwm yog 50 mg swb ob zaug ib hnub. Nyob ntawm qhov txo qis hauv cov ntshav siab, hydrochlorothiazide hauv ib lub koob tshuaj yuav tsum tau ntxiv rau qhov kev kho mob thiab / lossis koob tshuaj Lozap yuav tsum nce rau 100 mg ib zaug ib hnub.

Sab sij huam

Thaum kho nrog Lozap, cov neeg mob tau txhim kho qee qhov kev mob tshwm sim vim kev zam ib leeg ntawm cov ntsiav tshuaj:

Kev mob ntshav hauv daim siab, nce kev ua haujlwm ntawm hepatic transaminases,
Muaj ntshav qabzib ntxiv
Kev loj hlob ntawm cov hlau tsis muaj zog,
Tsis qab los noj mov, xeev siab, lub qhov ncauj qhuav, qee zaum ntuav thiab cov quav tsis haum,
Los ntawm cov leeg hlwb - pw tsis tsaug zog, tsis xis nyob, mob taub hau, nce tshee sai sai, hauv cov neeg mob neurocirculatory kawg, muaj kev ntshai tuaj tawm tsam, kev nyuaj siab, tshee tshee ntawm qhov kawg,
Kev ua xua tawm tsam - cov tsos mob ua pob rau ntawm daim tawv nqaij, txoj kev txhim kho ntawm Quincke's edema lossis anaphylaxis,
Qhov muag tsis pom kev, hnov lus tsis tseeb, hais lus zoo,
Los ntawm ib sab ntawm lub siab thiab cov hlab ntshav - ib qho kev txo qis hauv cov ntshav siab, tsaus muag, ua tsis taus pa, tachycardia, tsaus muag hauv qhov muag, tsaus muag, kiv taub hau,
Nyob rau ib feem ntawm cov kab mob ua pa - txoj kev loj hlob ntawm cov txheej txheem ntawm cov mob sab sauv, hnoos, bronchospasm, kev mob siab ntsws ntawm bronchial hawb pob, nce asthmatic tawm tsam,
Photosensitivity ntawm daim tawv nqaij.

Feem ntau, Lozap muaj kev tiv thaiv zoo, kev phiv yog dhau thiab tsis tas yuav tsum tsis ua txuas ntxiv ntawm cov tshuaj.

Cov Yuav Tsum Muaj

Cov tshuaj yuav tau noj tsuas yog tom qab sab laj ib tus kws tshwj xeeb. Ua ntej pib txoj kev kho mob, koj yuav tsum ua tib zoo kawm cov lus qhia rau cov ntsiav tshuaj, vim tias Lozap muaj cov kab mob hauv qab no:

hypersensitivity rau cov tshuaj nquag los yog excipients ntawm cov tshuaj
daim siab ua hauj lwm hnyav
cev xeeb tub thiab lactation
cov menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo
co-administration nrog aliskiren hauv cov neeg mob ntshav qab zib mellitus

Cov tshuaj sib cuam tshuam

Lwm cov tshuaj tiv thaiv kabmob tuaj yeem txhim kho cov nyhuv hypotensive ntawm Lozap. Kev siv tib lub sijhawm nrog lwm cov tshuaj uas tuaj yeem ua rau qhov tshwm sim ntawm txoj kev mob ntshav ntawm txoj hlab ntshav yog qhov tshwm sim tsis zoo (tricyclic antidepressants, antipsychotics, baclofen thiab amifostine) yuav ua rau muaj kev pheej hmoo ntawm hypotension.

Losartan metabolized feem ntau nrog kev koom tes ntawm cytochrome P450 (CYP) 2C9 system mus rau cov nquag carboxylic acid metabolite. Hauv qhov kev tshawb fawb soj ntsuam, nws tau pom tias fluconazole (tshuaj tiv thaiv ntawm CYP2C9) txo cov kev cuam tshuam ntawm cov metabolite nquag kwv yees li 50%. Nws tau pom tias kev kho mob tib lub sijhawm nrog losartan thiab rifampicin (ib qho inducer ntawm metabolic enzymes) ua rau 40% tsawg dua nyob rau hauv kev ua si ntawm cov nquag metabolite hauv cov ntshav ntshav. Cov tseem ceeb kab mob ntawm cov nyhuv no tsis paub. Nws tsis muaj qhov sib txawv hauv kev cuam tshuam nrog kev siv Lozap tib txhij nrog fluvastatin (tsis muaj zog CYP2C9 inhibitor).

Ib yam li lwm yam tshuaj uas thaiv angiotensin II lossis nws cov txiaj ntsig, kev siv cov tshuaj uas muaj cov tshuaj potassium nyob hauv lub cev (piv txwv li potassium-sparing diuretics: spironolactone, triamteren, amiloride), lossis tuaj yeem nce qib potassium ntxiv (piv txwv li heparin) ntxiv rau cov tshuaj potassium lossis cov ntsev ntxiv, tuaj yeem ua rau ntau ntxiv cov poov tshuaj potassium. Peb tsis pom zoo siv cov nyiaj ib zaug no.

Kev rov ua tau ntxiv nyob rau hauv cov ntshiab lithium ntau ntxiv, nrog rau cov tshuaj lom, tau tshaj tawm nrog kev siv tib lub sijhawm ntawm lithium nrog ACE inhibitors. Tsis tas li, cov xwm txheej nrog kev siv cov tshuaj mob angiotensin II receptor antagonists kuj tau muaj tsawg kawg. Kev txiav txim siab ceev faj nrog lithium thiab losartan yuav tsum tau ua nrog ceev faj. Yog tias siv cov kev sib xyaw ua ke suav tias yog qhov tsim nyog, nws raug nquahu kom kuaj xyuas cov qib lithium thaum lub sijhawm siv.

Nrog rau kev siv ua ke ntawm angiotensin II antagonists thiab cov tshuaj tsis-steroidal anti-inflammatory (piv txwv li, xaiv cyclooxygenase-2 inhibitors (COX-2), acetylsalicylic acid hauv cov tshuaj uas muaj cov tshuaj tiv thaiv, tsis muaj tshuaj lom tshuaj, tsis muaj txiaj ntsig los tiv thaiv kev tsis haum tshuaj. Kev siv cov tshuaj tiv thaiv angiotensin II muaj kev cuam tshuam lossis cov tshuaj diuretics nrog NSAIDs tuaj yeem ua rau muaj kev pheej hmoo ntawm lub raum tsis ua haujlwm, suav nrog kev txhim kho ntawm kev mob raum tsis ua haujlwm, nrog rau kev nce ntshav ntau ntxiv, tshwj xeeb tshaj yog nyob rau cov neeg mob uas lub raum cia siab. Qhov kev sib xyaw no yuav tsum yog daim ntawv ceeb toom nrog ceev faj, tshwj xeeb tshaj yog rau cov neeg laus. Cov neeg mob yuav tsum tau mus tso dej kom tsim nyog, thiab yuav tsum tau saib xyuas lub raum kev ua haujlwm tom qab pib siv tshuaj kho, thiab tom qab ntawv tsis tseg.

Kev ua haujlwm tsis zoo

Angioneurotic edema. Cov neeg mob uas muaj keeb kwm ntawm mob caj dab (angioneurotic edema) yuav tsum tau soj ntsuam ntau zaus.

Arterial hypotension thiab dej-electrolyte tsis txaus

Cov tsos mob ntawm lub ntsej muag liab, tshwj xeeb tshaj yog tom qab thawj zaug ntawm cov tshuaj lossis tom qab nce lub koob tshuaj, tuaj yeem tshwm sim rau cov neeg mob txo qis ntim hauv lub cev thiab / lossis cov dej qab ntsev, tshwm sim los ntawm kev siv zog diuretics, kev noj zaub mov kom tsis pub noj ntsev, raws plab lossis ntuav. Ua ntej pib txoj kev kho mob nrog Lozap, qhov kho ntawm cov mob zoo li no yuav tsum tau nqa tawm lossis cov tshuaj yuav tsum tau siv hauv qhov qis qis.

Kev ntsuas hluav taws xob tsis txaus

Kev ntsuas hluav taws xob tsis txaus yog feem ntau pom nyob rau hauv cov neeg mob uas lub raum tsis zoo (nrog lossis tsis muaj ntshav qab zib mellitus), uas yuav tsum tau suav nrog. Hauv cov neeg mob uas muaj hom ntshav qab zib hom mellitus thiab nephropathy, qhov tshwm sim ntawm hyperkalemia yog qhov siab dua hauv Lozap pawg dua li cov pab pawg placebo. Yog li, koj yuav tsum xyuas xyuas cov poov tshuaj ntau ntau hauv cov ntshav plasma thiab cov ntshav tshem tawm, tshwj xeeb tshaj yog nyob hauv cov neeg mob plawv tsis ua hauj lwm thiab creatinine tshem tawm 30 - 50 ml / feeb.

Kev siv ua ke ntawm cov tshuaj Lozap thiab potassium-khaws cia diuretics, cov tshuaj ntxiv poov tshuaj thiab ntsev hloov pauv muaj cov poov tshuaj tsis pom zoo.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, uas yog coated nrog ib zaj duab xis dawb txheej ntawm 12,5 mg, 50 mg thiab 100 mg. Oblong, biconvex ntsiav tshuaj. Blisters nrog cov ntsiav tshuaj ntawm 10 pcs. muag hauv cov thawv ntawv muag ntawm 30, 60, 90 pcs.

Cov tshuaj muaj pes tsawg leeg Lozap suav nrog losartan potassium (cov tshuaj ua kom nquag plias), povidone, microcrystalline cellulose, croscarmellose sodium, mannitol, magnesium stearate, hypromellose, talc, macrogol, xim daj, dimethicone (excipients).

Lozap ntxiv rau cov ntsiav tshuaj (ua ke nrog hydrochlorothiazide diuretic los txhim kho cov nyhuv), cov tshuaj nquag, losartan thiab hydrochlorothiazide.

Cov yam ntxwv ntawm Pharmacological

Cov tshuaj tiv thaiv antihypertensive - tsis yog peptide blocker ntawm receptors AT2, cov neeg sib tw ntawm cov receptors ntawm subtype AT1. Los ntawm kev thaiv cov receptors, Lozap inhibits qhov khi ntawm angiotensin 2 rau AT1 receptors, uas ua rau cov teebmeem hauv qab no ntawm AT2 tau qib: kev mob ntshav siab, tso tawm ntawm renin thiab aldosterone, catecholamines, vasopressin, thiab kev txhim kho ntawm LVH. Cov tshuaj tsis thaiv cov angiotensin-hloov mus rau enzyme, uas txhais tau hais tias nws tsis cuam tshuam rau lub zog system thiab tsis ua rau kev txuam nrog ntawm bradykinin

Lozap hais txog cov prodrugs, txij li nws cov metabolite (ib qho tshuaj metabolite ntawm carboxylic acid), tsim thaum lub sijhawm biotransformation, muaj cov nyhuv antihypertensive.

Tom qab ib koob tshuaj nkaus xwb, cov txiaj ntsig antihypertensive (txo qis hauv systolic thiab diastolic ntshav siab) nce mus txog qhov siab tshaj plaws tom qab 6 teev, tom qab ntawd maj mam txo qis hauv 24 teev. Qhov siab tshaj plaws antihypertensive nyhuv tau tiav 3-6 lub lis piam tom qab pib ntawm cov tshuaj.

Cov lus qhia rau kev siv

Lozap noj qhov ncauj, tsis muaj kev tos los ntawm kev ua zaub mov noj. Cov ntsiav tshuaj yuav tsum noj ib hnub ib zaug. Cov neeg mob ua mob ntshav liab mob ntshav noj tshuaj ntawm 50 mg ib hnub twg. Txhawm rau kom pom kev pom tseeb dua, kev txhaj tshuaj qee zaum ntxiv rau 100 mg. Yuav ua li cas noj Lozap hauv qhov no, tus kws kho mob muab cov lus pom zoo ntawm tus kheej.

Cov lus qhia rau Lozap N qhia tias cov neeg mob lub siab tsis haum noj tshuaj 12,5 mg ib hnub ib zaug. Maj mam, cov koob tshuaj ntawm cov tshuaj no yog ob npaug nrog ib nrab ntawm ib lub lis piam mus txog thaum ntawd, kom txog thaum nws nce mus txog 50 mg ib hnub ib zaug.

Cov lus qhia rau kev siv Lozap Plus koom nrog noj ib ntsiav tshuaj ib hnub ib zaug. Qhov loj tshaj plaws ntawm cov tshuaj yog 2 ntsiav tshuaj hauv ib hnub.

Yog tias ib tus neeg noj cov tshuaj diuretic siab ntau hauv tib lub sijhawm, qhov tshuaj txhua hnub ntawm Lozap raug txo mus rau 25 mg.

Cov neeg laus thiab cov neeg mob uas lub raum tsis ua haujlwm (suav nrog cov neeg mob hemodialysis) tsis tas yuav kho qhov tshuaj ntau npaum li cas.

Sab sij huam

Ntau yam kev phiv tshuaj muaj peev xwm ua tau: mob tawv nqaij, mob caj dab, mob anaphylactic poob siab. Nws tseem muaj peev xwm txo qis ntshav siab, qaug zog, kiv taub hau. Tsis tshua muaj kab mob siab, kab mob siab, migraine, myalgia, mob ua pa, dyspepsia, mob siab ua haujlwm.

Cov tsos mob ntawm kev noj haus ntau dhau yog hypotension, tachycardia, tab sis bradycardia kuj ua tau. Kev kho yog txhawm rau tshem tawm cov tshuaj tawm hauv lub cev thiab tshem tawm cov tsos mob ntawm kev siv ntau dhau.

Siv thaum cev xeeb tub thiab lactation

Tsis txhob kho Lozap thaum cev xeeb tub. Thaum kho nyob rau hauv kev txiav plaub hauv thib ob thiab thib peb nrog cov tshuaj uas cuam tshuam rau lub cev renin-angiotensin, muaj qhov tsis xws luag hauv kev txhim kho ntawm lub cev thiab txawm tias muaj kev tuag tuaj yeem tshwm sim. Thaum lub sijhawm cev xeeb tub tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd.

Yog tias Lozap yuav tsum tau noj thaum lub sijhawm lactation, kev pub mis rau menyuam yuav tsum nres tam sim ntawd.

Yuav coj menyuam li cas?

Qhov ua tau zoo ntawm kev raug thiab kev nyab xeeb ntawm kev siv hauv cov menyuam yaus tseem tsis tau tsim, yog li ntawd, cov tshuaj tsis siv los kho menyuam yaus.

Tag nrho cov analogues ntawm cov tshuaj nquag:

Blocktran
Brozaar
Vasotens,
Vero-Losartan,
Zisakar
Cardomin Sanovel,
Karzartan
Cozaar
Lakea
Lozarel
Losartan
Losartan poov tshuaj,
Lorista
Losacor
TubhmoovTiam
Ntsiag To.

Thaum xaiv cov analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv Lozap, tus nqi thiab tshuaj xyuas cov tshuaj uas muaj cov txiaj ntsig zoo tsis raug. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Lozap lossis Lorista - uas zoo dua?

Cov tshuaj nquag hauv yeeb tshuaj Lorista tsuas yog tib yam li hauv Lozap. Lorista yog kho rau cov neeg mob kev mob ntshav liab thiab mob plawv nres. Tib lub sijhawm, tus nqi ntawm cov tshuaj Lorista qis dua. Yog tias tus nqi ntawm Lozap (30 pcs.) Yog kwv yees 290 rubles, ces tus nqi ntawm 30 ntsiav tshuaj ntawm cov tshuaj Lorista yog 140 rubles. Txawm li cas los xij, koj tuaj yeem siv cov analogue tsuas yog tom qab sab laj nrog tus kws kho mob thiab tom qab cov ntawv nyeem tau nyeem zoo zoo.

Dab tsi yog qhov txawv ntawm Lozap thiab Lozap Plus?

Yog tias koj xav tau kev kho mob nrog cov tshuaj no, cov lus nug feem ntau tshwm sim, uas yog qhov zoo dua - Lozap lossis Lozap Plus?

Thaum xaiv cov tshuaj, nws yuav tsum raug sau tseg tias nyob rau hauv kev sib xyaw ntawm Lozap Plus, losartan thiab hydrochlorothiazide yog cov sib xyaw, uas yog cov diuretic thiab muaj cov diuretic ntxim rau lub cev. Yog li, cov ntsiav tshuaj no tau qhia rau cov neeg mob uas xav tau kev kho mob sib xyaw.

Cov lus qhia tshwj xeeb

Hauv cov neeg mob uas tsis tshua muaj lub cev ntshav tsawg (ib qho kev tshwm sim tsis tu ncua ntawm kev siv tshuaj ntau dhau ntawm lub sijhawm diuretics), Lozap® tuaj yeem ua rau muaj kev loj hlob ntawm cov tsos mob ntawm cov ntshav txhaws. Yog li, ua ntej pib kho nrog cov tshuaj no, nws yog ib qho tsim nyog yuav tsum tau tshem tawm cov kev ua txhaum uas twb muaj lawm, lossis siv cov tshuaj hauv cov tshuaj me me.

Cov neeg mob uas tau mob los ntawm kev mob ntshav siab (daim siab me los sis mob hnyav) tom qab siv tus neeg sawv cev siab, qhov siab ntawm cov khoom nquag thiab nws cov tshuaj tiv thaiv nquag tau nce siab dua hauv cov neeg noj qab haus huv. Hauv qhov no, hauv qhov xwm txheej no, kuj nyob rau hauv cov txheej txheem ntawm kev kho, txo cov koob tshuaj yuav tsum tau ua.

Thaum lub cev tsis zoo ua haujlwm, kev loj hlob ntawm hyperkalemia (nce poov tshuaj concentration hauv cov ntshav) tau. Yog li no, thaum tab tom kho cov kab mob, nws yuav tsum tau saib xyuas kom tsawg ntawm cov qib microelement no.

Nrog rau kev tswj hwm ua ke ntawm cov tshuaj uas cuam tshuam rau renin-angiotensin system nyob rau hauv cov neeg mob raum mob raum (ib leeg lossis ob tog), cov ntshav creatinine thiab urea tuaj yeem nce ntxiv. Tom qab kev txiav tawm ntawm cov tshuaj, tus mob feem ntau normalizes. Hauv qhov xwm txheej no, nws tseem yog qhov yuav tsum tau ua hauv kev soj ntsuam tas mus li ntawm cov theem ntawm cov kab mob biochemical ntawm kev ua haujlwm ntawm lub raum glomerular.

Cov ntaub ntawv hais txog cov nyhuv ntawm Lozap ntawm kev muaj peev xwm tsav tsheb los yog ua haujlwm ua haujlwm uas xav tau kev nce siab ntawm cov xim thiab qhov ceev ntawm cov kev xav psychomotor tsis tau txheeb xyuas.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj tuaj yeem tsim tawm nrog lwm tus neeg sawv cev antihypertensive. Kev sib nrig sib ntxiv ntawm qhov tshwm sim ntawm beta-blockers thiab sympatholytics yog pom. Nrog rau kev siv sib xyaw ua ke ntawm losartan nrog diuretics, ib qho txiaj ntsig zoo raug pom.

Tsis muaj pharmacokinetic cuam tshuam ntawm losartan nrog hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole thiab erythromycin tau sau tseg.

Cov tshuaj Rifampicin thiab fluconazole tau qhia tawm txog kev txo qis cov tshuaj lom metabolite ntawm losartan hauv cov ntshav ntshav. Cov kab mob tseem ceeb ntawm cov kev sib txuam no tseem tsis tau paub.

Ib yam li lwm tus neeg sawv cev uas inhibit angiotensin 2 los yog nws cov txiaj ntsig, kev siv ua ke ntawm losartan nrog cov tshuaj potassium-sparing diuretics (piv txwv li, spironolactone, triamteren, amiloride), cov tshuaj potassium npaj thiab cov ntsev uas muaj cov potassium ntxiv ua rau muaj kev pheej hmoo ntawm hyperkalemia.

NSAIDs, nrog rau xaiv COX-2 inhibitors, tuaj yeem txo cov nyhuv ntawm diuretics thiab lwm cov tshuaj tiv thaiv kev tiv thaiv.

Nrog rau kev siv ua ke ntawm angiotensin 2 thiab lithium receptor antagonists, nce ntxiv ntawm plasma lithium concentration yog tau. Muab qhov no, nws yog qhov yuav tsum tau hnyav lub txiaj ntsig thiab kev pheej hmoo ntawm kev tswj hwm ntawm losartan nrog lithium ntsev npaj. Yog tias siv kev sib koom ua ke yog qhov tsim nyog, kev saib xyuas ntawm cov roj ntsha lithium hauv cov ntshav ntshav yuav tsum tau soj ntsuam kom tsis tu ncua.

Cov kev rov xyuas dua tham txog dab tsi?

Kev tshuaj xyuas ntawm Lozap Plus thiab Lozap qhia tau hais tias feem ntau, cov tshuaj muaj txiaj ntsig txo cov ntshav siab thiab muaj cov txiaj ntsig zoo ntawm kev noj qab haus huv ntawm cov neeg muaj kab mob ntawm cov hlab plawv.

Cov neeg mob uas mus rau hauv lub rooj sib tham tshwj xeeb kom tawm tswv yim ntawm Lozap 50 mg ceeb toom tias hnoos, qhov ncauj qhuav, thiab tsis hnov lus zoo qee zaum sau tseg tias yog kev phiv. Tab sis feem ntau, cov neeg mob tshuaj xyuas txog cov tshuaj muaj qhov zoo.

Tib lub sijhawm, kev tshuaj xyuas cov kws kho mob pom tau tias cov tshuaj yuav tsis haum rau txhua tus neeg uas muaj mob ntshav siab. Yog li, thaum pib yuav tsum ua raws li kev saib xyuas nruj ntawm ib tus kws tshaj lij.

Lub siab ua haujlwm tsis zoo

Kev ua tib zoo xav txog cov ntaub ntawv pharmacokinetic qhia txog kev nce siab ntawm Lozap hauv cov ntshav ntshav hauv cov neeg mob uas muaj lub siab ua haujlwm, keeb kwm ntawm kev txo cov tshuaj rau cov neeg mob uas lub siab tsis zoo yuav tsum xav txog. Cov tshuaj Lozap yuav tsum tsis txhob siv rau hauv cov neeg mob uas lub siab tsis ua haujlwm hnyav vim tsis muaj kev paub dhau los.

Lub raum khiav tsis zoo

Kev hloov pauv ntawm lub raum kev ua haujlwm, suav nrog lub raum tsis ua haujlwm, cuam tshuam nrog kev txwv tsis pub cov kab mob renin-angiotensin tau tshaj tawm (tshwj xeeb tshaj yog nyob rau cov neeg mob raum-angiotensin-aldosterone system, i.e. cov neeg mob uas muaj mob tsis zoo lossis nrog lub raum ua xiam lawm). Raws li nrog rau lwm cov tshuaj uas cuam tshuam rau renin-angiotensin-aldosterone system, kev nce ntshav ntawm urea thiab serum creatinine qib tau tshaj tawm nyob rau hauv cov neeg mob uas muaj ob leeg lub raum leeg mob stenosis los yog nrog stenosis ntawm ib lub raum artery. Cov kev hloov ntawm lub raum kev ua haujlwm no tuaj yeem hloov rov qab tau tom qab tsis ua tiav ntawm kev kho. Ceev faj yuav tsum tau siv thaum siv Lozap hauv cov neeg mob uas muaj ob lub raum leeg ntshav ob leeg los yog mob qog ntshav ntawm lub raum leeg.

Siv tib lub sijhawm Lozap thiab ACE inhibitors cuam tshuam lub raum ua haujlwm, yog li ntawd qhov kev sib xyaw no tsis pom zoo.

Lub plawv tsis ua hauj lwm

Ib yam li lwm yam tshuaj uas cuam tshuam rau renin-angiotensin system, nyob rau hauv cov neeg mob uas lub plawv tsis ua haujlwm nrog / tsis muaj qhov ua kom lub raum tsis ua haujlwm, muaj kev pheej hmoo ntawm txoj hlab ntshav siab heev thiab (feem ntau mob) ua rau lub raum tsis ua haujlwm.

Muaj kev paub tsis meej txaus nrog kev siv Lozap hauv cov neeg mob lub plawv tsis ua hauj lwm thiab ua rau lub raum tsis ua hauj lwm zoo, hauv cov neeg mob uas muaj lub plawv tsis ua hauj lwm loj (qib IV raws li NYHA), zoo li yog rau cov neeg mob lub plawv tsis ua hauj lwm thiab muaj tsos mob, ua rau lub plawv mob plawv tsis ua hauj lwm. Yog li, Lozap yuav tsum siv nrog ceev faj hauv pab pawg ntawm cov neeg mob no. Kev ceev faj yog qhia kom siv Lozap thiab beta-blockers tib lub sijhawm.

Stenosis ntawm aortic thiab mitral li qub, obstructive hypertrophic cardiomyopathy.

Ib yam li lwm cov vasodilators, cov tshuaj yog kws kho nrog kev saib xyuas tshwj xeeb rau cov neeg mob aortic thiab mitral valve stenosis lossis ob leeg mob hypertrophic cardiomyopathy.

Siv thaum cev xeeb tub thiab lactation

Lozap yuav tsum tsis txhob raug tshuaj thaum cev xeeb tub. Yog tias kev kho mob nrog losartan tsis tseem ceeb, yog li cov neeg mob npaj lub cev xeeb tub yuav tsum tau noj lwm yam tshuaj tiv thaiv kab mob antihypertensive uas muaj kev nyab xeeb thaum cev xeeb tub. Thaum cev xeeb tub, Lozap kho yuav tsum nres tam sim ntawd thiab lwm txoj kev kho ntshav yuav tsum siv los tswj ntshav siab.

Thaum sau daim ntawv tshuaj rau lub sijhawm lactation, ib qho kev txiav txim siab yuav tsum tau txiav txim siab kom tsis txhob pub niam mis lossis tsum tsis txhob kho nrog Lozap.

Peculiarities ntawm cov nyhuv ntawm cov tshuaj nyob rau hauv tsav tsheb los yog lwm yam kev phom sij uas muaj feem

Tsis muaj cov kev tshawb fawb tau ua rau muaj kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog cov txheej txheem. Txawm li cas los xij, thaum tsav tsheb tsav thiab ua haujlwm nrog cov txheej txheem, ib qho yuav tsum nco ntsoov tias thaum noj tshuaj antihypertensive, kiv taub hau lossis qaug zog tuaj yeem tshwm sim qee zaum, tshwj xeeb tshaj yog thaum pib kho lossis thaum noj tshuaj nce.

Noj ntau dhau

Nrog rau qhov nce ntxiv ntawm cov tshuaj pom zoo lossis kev siv lub sijhawm ntev uas tsis siv tshuaj, cov neeg mob tau tsim lub cim ntawm kev noj tshuaj ntau dhau, uas tau hais tawm hauv kev nce ntxiv hauv cov kev mob tshwm sim piav qhia saum toj no thiab qhov tseem ceeb txo cov ntshav siab. Tsis tas li ntawd xwb, vim muaj ntau zog ntawm cov kua thiab microelements los ntawm lub cev, dej-electrolyte tsis txaus.

Nrog kev txhim kho ntawm cov kev mob tshwm sim, kev kho nrog Lozap yog nres tam sim ntawd thiab tus neeg mob xa mus rau tus kws kho mob. Tus neeg mob tau qhia tias lub plab zom zaub mov (siv tau yog tias cov tshuaj noj tsis ntev los no), kev tswj hwm ntawm sorbents sab hauv thiab kev kho mob - tshem tawm ntawm lub cev qhuav dej, rov qab ua kom muaj ntsev ntau ntxiv hauv lub cev, ua kom ntshav siab thiab lub plawv.