Metformin 500 mg 60 ntsiav tshuaj: nqe thiab analogues, tshuaj xyuas

Cov ntsiav tshuaj, 500 mg, 850 mg thiab 1000 mg

Ib qho 500 mg ntsiav tshuaj ntim:

cov tshuaj heev: metformin hydrochloride - 500 mg.

hauvzam txim: microcrystalline cellulose, croscarmellose sodium, dej lim, povidone (polyvinylpyrrolidone), magnesium stearate.

Ib 850 mg ntsiav tshuaj muaj:

cov tshuaj heev: metformin hydrochloride - 850 mg.

hauvpabcuam tshuaj: microcrystalline cellulose, croscarmellose sodium, dej lim, povidone (polyvinylpyrrolidone), magnesium stearate.

Ib qho 1000 mg ntsiav tshuaj muaj:

nquag cov tshuaj yeeb dej caw: metformin hydrochloride - 1000 mg.

auxkho kom zoo tshuaj: microcrystalline cellulose, croscarmellose sodium, dej lim, povidone (polyvinylpyrrolidone), magnesium stearate.

500 mg ntsiav tshuaj - puag ncig tiaj-cylindrical ntsiav tshuaj ntawm cov xim dawb lossis yuav luag xim dawb nrog kev pheej hmoo ntawm ib sab thiab ib chamfer ntawm ob sab.

Cov ntsiav tshuaj 850 mg, 1000 mg - oval biconvex ntsiav tshuaj ntawm cov xim dawb lossis yuav luag dawb nrog kev pheej hmoo ntawm ib sab.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab cov neeg siv qhov ncauj, metformin yog nqus tau ntawm txoj hnyuv mus tag nrho. Kev tsis raug cai ntawm bioavailability yog 50-60%. Qhov siab tshaj plaws (Cmax) (kwv yees li 2 μg / ml lossis 15 μmol) hauv ntshav tau txog tom qab 2.5 teev.

Nrog kev noj ib txhij, kev nqus ntawm metformin yog txo thiab qeeb.

Metformin tau faib sai sai hauv cov ntaub so ntswg, kev xyaum ua haujlwm tsis khi rau cov ntshav protein. Nws yog metabolized mus rau ib tug kawm ntawv uas tsis muaj zog thiab tawm los ntawm ob lub raum. Kev tshem tawm ntawm metformin hauv cov ntsiab lus noj qab haus huv yog 400 ml / min (4 lub sijhawm ntau dua li creatinine tshem tawm), uas qhia tias muaj cov kwj dej muaj kev zais cia. Ib nrab-lub neej yog kwv yees li 6,5 teev. Nrog raum tsis ua haujlwm, nws nce, muaj kev pheej hmoo ntawm kev txuam nrog cov tshuaj.

Metformin txo hyperglycemia yam uas tsis ua rau kev txhim kho ntshav qab zib hauv lub ntsej muag. Tsis zoo li sulfonylurea derivatives, nws tsis txhawb kev tiv thaiv insulin secretion thiab tsis muaj qhov cuam tshuam hypoglycemic hauv cov neeg noj qab haus huv. Tsub qhov rhiab heev ntawm peripheral receptors rau insulin thiab kev siv cov kua nplaum los ntawm lub hlwb. Nws inhibits gluconeogenesis nyob rau hauv daim siab. Ncua kev nqus ntawm cov carbohydrates hauv cov hnyuv. Metformin stimulates glycogen synthesis los ntawm kev ua ntawm glycogen synthase. Tsub kom muaj peev xwm thauj tau txhua yam ntawm cov khoom thauj ua kua roj ntau dua.

Tsis tas li ntawd, nws muaj txiaj ntsig zoo rau lipid metabolism: nws txo cov ntsiab lus ntawm cov roj (cholesterol) tag nrho, cov lipoproteins tsawg thiab triglycerides.

Thaum noj cov tshuaj metformin, tus neeg mob lub cev hnyav dua li qub tseem ruaj khov lossis txo qis.

Kev ntsuas rau siv

Hom 2 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog rau cov neeg mob rog rog, nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo thiab ua si lub cev:

• rau cov laus, xws li kho ntshav lossis siv nrog lwm tus neeg hauv lub qhov ncauj hypoglycemic, lossis nrog insulin,

• hauv cov menyuam yaus txij thaum muaj hnub nyoog 10 xyoo los ua kev kho ib ce lossis siv cov tshuaj insulin.

Tsuas tshuaj thiab tswj hwm

Cov ntsiav tshuaj yuav tsum tau noj ntawm qhov ncauj, nqos tag nrho, tsis ntxo, thaum lub sijhawm lossis tom qab noj mov tas, haus dej ntau.

Cov neeg laus: monotherapy thiab kev sib txuas ua ke hauv kev kho mob hauv kev sib xyaw nrog lwm tus neeg hauv qhov ncauj hypoglycemic:

• Lub caij pib noj ib txwm yog 500 mg lossis 850 mg 2-3 zaug ib hnub tom qab lossis thaum noj mov. Ib qho kev nce zuj zus ntxiv hauv koob tshuaj yog muaj peev xwm ua tau raws li kev mloog ntawm cov piam thaj hauv cov ntshav.

• Kev saib xyuas cov tshuaj ntawm cov tshuaj feem ntau yog 1500-2000 mg / hnub. Txhawm rau kom txo cov kev mob tshwm sim los ntawm txoj hnyuv plab, qhov tshuaj txhua hnub yuav tsum tau muab faib ua 2-3 zaug. Qhov ntau tshaj plaws yog 3000 mg / hnub, muab faib ua peb koob.

• Kev noj tshuaj qeeb me ntsis tuaj yeem txhim kho lub plab zom mov.

• Cov neeg mob noj cov tshuaj metformin hauv koob tshuaj 2000-3000 mg / hnub tuaj yeem hloov mus rau 1000 mg. Qhov kev xav tau ntau tshaj plaws yog 3000 mg / hnub, muab faib ua 3 koob.

Tus neeg npaj yuav hloov mus los ntawm kev siv lwm tus neeg sawv cev hypoglycemic: koj yuav tsum tsis txhob noj lwm yam tshuaj thiab pib noj cov tshuaj Metformin nyob rau hauv cov koob tshuaj uas tau hais los saud.

Ua ke nrog cov tshuaj insulin:

Yuav kom ua tiav cov tswj ntshav qab zib kom zoo, metformin thiab insulin tuaj yeem siv los ua kev kho mob ua ke. Qhov koob tshuaj uas ib txwm pib ntawm Metformin 500 mg lossis 850 mg yog ib ntsiav tshuaj 2-3 zaug hauv ib hnub, Metformin 1000 mg yog ib ntsiav tshuaj 1 zaug hauv ib hnub, thaum lub koob tshuaj insulin raug xaiv raws li cov concentration ntawm cov piam thaj hauv cov ntshav.

Cov menyuam yaus thiab cov tub ntxhais hluas: hauv cov menyuam yaus txij li 10 xyoo, cov tshuaj Metformin tuaj yeem siv tau ob qho tib si hauv kev kho mob monotherapy thiab ua ke nrog insulin. Qhov kev pib noj ib txwm yog 500 mg lossis 850 mg 1 zaug nyob rau ib hnub tom qab lossis thaum noj mov. Tom qab 10-15 hnub, qhov tshuaj yuav tsum raug kho raws li kev nqus ntawm cov ntshav qabzib. Qhov siab rau ib hnub ntau npaum li cas yog 2000 mg, faib ua 2-3 koob.

Cov neeg laus laus: vim kev txo qis hauv kev ua haujlwm ntawm lub raum, cov koob tshuaj metformin yuav tsum raug xaiv los ntawm kev saib xyuas lub raum kev ua haujlwm tsis tu ncua (txiav txim siab qhov tsim nyog ntawm creatinine hauv ntshav tsawg kawg 2-4 zaug hauv ib xyoos).

Lub sijhawm tiv thaiv yog txiav txim los ntawm tus kws kho mob. Kev tsis haus yeeb tshuaj yam tsis muaj kev qhia los ntawm koj tus kws kho mob tsis pom zoo.

Kev siv tshuaj

Metformin ntsiav tshuaj noj ntawm qhov ncauj.

Thaum noj tshuaj, nws raug nquahu kom cov ntsiav tshuaj nqos tag nrho yam tsis muaj kev cheem.

Cov tshuaj yuav tsum tau siv thaum noj mov lossis siv tam sim ntawd. Siv cov ntsiav tshuaj nrog qhov ntim dej txaus.

Qhov tseem ceeb qhia tau rau kev siv tshuaj yog kev muaj ntshav qab zib hom 2 hauv tus neeg mob.

Cov lus qhia rau kev siv qhia tau tias cov tshuaj tuaj yeem siv hauv cov txheej txheem ntawm kev kho mob monotherapy lossis ua ib feem ntawm cov kev kho mob nyuaj nrog lwm cov tshuaj nrog hypoglycemic lub zog lossis ua ke nrog inulin.

Cov lus qhia rau kev siv tso cai rau kev siv cov tshuaj hauv cov menyuam yaus, pib txij li 10 xyoo. Kev siv cov tshuaj tau tso cai rau menyuam yaus ob qho tib si li kev kho mob monotherapy, thiab hauv kev sib xyaw nrog kev txhaj tshuaj insulin.

Qhov kev muab tshuaj thaum pib noj cov tshuaj yog 500 mg. Cov tshuaj pom zoo kom noj 2-3 zaug nyob rau ib hnub. Yog tias tsim nyog, nrog kev tswj hwm txuas ntxiv, cov koob tshuaj ntawm cov tshuaj yuav tau nce ntxiv. Kev nce ntxiv rau hauv cov ntau npaum li cas yog nyob ntawm qib uas cov piam thaj hauv lub cev.

Thaum siv Metformin hauv txoj haujlwm ntawm kev saib xyuas kev noj qab haus huv, qhov kev siv ntau npaum li cas nws txawv ntawm 1,500 mus txog 2,000 mg ib hnub. Qhov muab tshuaj rau txhua hnub yuav tsum tau muab faib ua 2-3 zaug, qhov kev siv tshuaj no zam kev tsis pom qhov tshwm sim tsis zoo ntawm lub plab hnyuv plab. Qhov siab tshaj plaws pub siv tau raws li cov lus qhia rau kev siv yog 3000 mg rau ib hnub.

Thaum noj tshuaj, ntau npaum yuav tsum maj mam nce kom txog rau qhov pom pom qhov txiaj ntsig zoo, txoj hauv kev no yuav txhim kho qhov thev taus ntawm cov tshuaj rau lub plab zom mov.

Yog tias tus neeg mob pib noj cov tshuaj Metformin tom qab lwm yam tshuaj hypoglycemic, tom qab ntawd ua ntej siv cov Metformin lwm yam tshuaj yuav tsum nres.

Thaum siv cov tshuaj no thaum yau, kev siv tshuaj yuav tsum pib nrog kev noj tshuaj ntawm 500 mg ib hnub ib zaug. Tom qab 10-15 hnub, kuaj ntshav rau cov piam thaj tau nqa tawm thiab, yog tias tsim nyog, qhov ntau npaum ntawm cov tshuaj noj tau hloov kho. Qhov siab tshaj plaws qhov ntau npaum li cas cov tshuaj rau cov neeg mob hauv cov menyuam yaus yog 2000 mg. Qhov tshuaj no yuav tsum tau muab faib ua 2-3 koob tshuaj ib hnub.

Yog tias cov tshuaj siv los ntawm cov neeg laus, kev hloov kho tshuaj yuav tsum tau ua nyob rau hauv kev saib xyuas nruj ntawm cov kws kho mob koom nrog. Qhov kev thov no yog vim muaj qhov tseeb tias nyob hauv cov neeg laus, kev txhim kho ntawm ntau qib ntawm lub raum tsis ua haujlwm hauv lub cev yog qhov ua tau.

Lub sijhawm sijhawm ntawm kev siv cov tshuaj yog txiav txim siab los ntawm tus kws khomob mus koom.

Thaum lub sij hawm kho, kev kho mob yuav tsum tsis txhob muaj kev cuam tshuam yog tias tsis muaj lus qhia los ntawm tus kws kho mob.