Cov tshuaj tua kab mob tau ntev ntev los ruaj rau hauv tib neeg lub neej. Tam sim no koj tuaj yeem nrhiav cov tshuaj antimicrobial, tshuaj tua kab mob antibacterial, bactericidal gel los sis cov ntaub so, thiab lwm yam. Tab sis siv txhua txhais tau tias ua tib zoo siv. Tshwj xeeb tshaj yog thaum nws los txog rau cov tshuaj. Cov ntawv xov xwm hnub no yuav qhia koj tias Gentamicin-Akos yog dab tsi. Rau dab tsi siv tshuaj pleev no, thiab nyob rau hauv rooj plaub twg nws yog qhov zoo dua uas tsis lees nws, koj yuav kawm tau ntxiv.

Cov Tshuaj Pharmacokinetics

Tom qab thov, cov khoom lag luam yuav luag tsis nqus tawm sab nraud. Cov tshuaj sai ua rau ntawm qhov chaw mob lossis mob txhab.

Tom qab kev tswj hwm intramuscularly, cov tshuaj nquag hloov tawm sai. Kev zam yog nrog zis thiab kua tsib. Nws khi me ntsis rau cov ntshav protein ntshav.

Qhov nqus ntawm qhov muag poob yuav qhia tau tias tsis tseem ceeb.

Cov Yuav Tsum Tau Ua

Cov tshuaj pleev tsis pom zoo rau kev siv tshuaj kho mob yog tias ib tus neeg muaj qhov mob rhiab heev rau ib feem ntawm cov tshuaj (suav nrog keeb kwm) lossis aminoglycosides, uremia, hnov mob neuritis, mob raum tsis zoo.

Gentamicin Akos yog siv rau hauv kev kho kab mob qhov muag mob.

Cov Tshuaj Hauv Tshuaj

Nws khi rau 30S subunit ntawm ribosomes thiab cuam tshuam kev cuam tshuam protein synthesis, tiv thaiv kev tsim ntawm txoj kev thauj mus los thiab kev xa xov RNA, thiab cov caj ces yog nyeem yuam kev thiab cov keeb ua haujlwm tsis ua haujlwm tau tsim. Nyob rau hauv qhov muaj zog ntau, nws ua txhaum lub nruas kev ua haujlwm ntawm cytoplasmic membrane thiab ua rau kev tuag ntawm cov kab mob me me.

Ua tau zoo tiv thaiv ntau cov kab mob gram-zoo thiab gram-tsis zoo. Gram-negative microorganisms - Proteus spp. Raug zoo heev rau gentamicin (MPC tsawg dua 4 mg / l). (suav nrog indole-positive thiab indole-negative strains), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., kab mob gram-positive - Staphylococcus spp. (suav nrog rau penicillin-resistant), rhiab nrog MPC 4–8 mg / l - Serratia spp., Klebsiella spp., Pseudomonas spp. (suav nrog Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. Resistant (MPC ntau dua 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Streptococcus spp. (suav nrog Streptococcus pneumoniae thiab pab pawg D leeg), Bacteroides spp., Clostridium spp., Providencia rettgeri. Hauv kev sib xyaw nrog penicillins (suav nrog benzylpenicillin, ampicillin, carbenicillin, oxacillin), ua rau ntawm kev sib txuas ntawm cov xovtooj ntawm phab ntsa ntawm cov kab mob me, nws ua haujlwm tawm tsam Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus faiumium thiab yuav luag txhua yam Streptococ leeg thiab ntau yam (suav nrog Streptococcus faecalis liguifaciens, Streptococcus faecalis zymogenes), Streptococcus faecium, Streptococcus durans. Qhov kev cuam tshuam ntawm cov kab mob me me mus rau gentamicin kev loj hlob qeeb, txawm li cas los xij, cov kab mob tsis haum nrog neomycin thiab kanamycin kuj tseem tuaj yeem tiv taus gentamicin (tsis tiav ua tiav khaub lig-tsis kam). Tsis cuam tshuam rau anaerobes, kab mob fungi, kab mob, protozoa.

Noj ntau dhau

Cov tsos mob: qis neuromuscular conduction (ua pa ntes).

Kev Kho Mob: tshuaj los tiv thaiv cholinesterase (Proserinum) thiab calcium npaj (5-10 ml ntawm 10% kev daws teeb meem ntawm calcium chloride, 5-10 ml ntawm 10% kev daws teeb meem ntawm calcium gluconate) tau qhia rau cov neeg laus. Ua ntej kev qhia ntawm Prozerin, atropine hauv ib koob li 0.5-0.7 mg yog preliminarily muab iv iv, kev nce qib ntawm mem tes yuav tsum, thiab 1.5-2 min tom qab, 1.5 mg (3 ml ntawm 0,05% kev daws) ntawm Prozerin tau txhaj. Yog hais tias cov nyhuv ntawm qhov tshuaj no tsis txaus, koob tshuaj tib yam ntawm Prozerin raug muab rov qab siv (nrog cov tsos ntawm bradycardia, txhaj ntxiv ntawm atropine yog muab). Cov menyuam yaus tau txais cov tshuaj calcium calcium. Thaum muaj mob hnyav los ntawm kev ua pa nyuaj, yuav tsum siv lub tshuab tso pa tawm. Nws tuaj yeem raug tshem tawm los ntawm hemodialysis (zoo dua) thiab peritoneal lim ntshav.