Cov menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo, cev xeeb tub, lactation (lub sijhawm pub niam mis), mob siab rau qhov tshuaj tsis haum.

Nrog kev ceev faj, sau ntawv rau cov ntsiav tshuaj ntawm cov tshuaj rau mob vwm (nrog rau keeb kwm), mob vwm, mob siab, tsis ua hauj lwm ntawm lub caij nyoog QT luv.

Moxifloxacin

Moxifloxacin: cov lus qhia rau kev siv thiab tshuaj xyuas

Lub npe Latin: Moxifloxacine

ATX Code: J01MA14

Cov tshuaj ua kom nquag plias: moxifloxacin (moxifloxacin)

Cov tsim tawm: Verteks AO (Russia), Hetero Labs Limited (Is Nrias teb), PFK Alium, LLC (Russia), Virend International, LLC (Russia), Promomed Rus, LLC (Russia)

Hloov kho cov lus piav qhia thiab yees duab: 11/22/2018

Cov nqi hauv khw muag tshuaj: los ntawm 396 rubles.

Moxifloxacin yog cov tshuaj tua kab mob ntawm cov kab mob ntawm cov kab mob dav dav.

Pharmacological kev txiav txim

Cov tshuaj tua kab mob los ntawm pab pawg fluoroquinolones, ua cov kab mob bactericidal. Nws ua tawm tsam ntau ntawm cov kab mob gram-positive thiab gram-tsis zoo, anaerobic, cov kab mob tiv thaiv acid thiab atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. Ua tau zoo tiv thaiv cov kab mob tiv thaiv kom tsis txhob raug beta-lactams thiab macrolides. Nws nquag tawm tsam feem ntau ntawm cov kab mob me me: gram-zoo - Staphylococcus aureus (suav nrog cov kab mob uas tsis rhiab txog methicillin), Streptococcus pneumoniae (suav nrog cov tshuaj tiv thaiv penicillin thiab macrolides), Streptococcus pyogenes (pawg A), gram-negative - Haemophilus influenzae (suav nrog thiab cov kab mob uas tsis yog-beta-lactamase uas tsim ua haujlwm), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (suav nrog rau ob leeg tsis-beta-tsim thiab tsis-beta-lactamase uas tsim cov kab mob), Escherichia coli, Enterobacter cloacae, atypical Chlamydia mob ntsws.

Sab sij huam

Los ntawm lub plab zom mov: mob plab, xeev siab, raws plab, ntuav, dyspepsia, pom quav, cem quav, nce kev ua haujlwm ntawm hepatic transaminases, perversion ntawm saj.

Los ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb txhaws: kiv taub hau, pw tsaug zog, poob siab, ntxhov siab, asthenia, mob taub hau, tshee tshee, caj dab, mob caj dab, cramps, tsis meej pem, kev nyuaj siab.

Los ntawm cov hlab plawv: tachycardia, peripheral edema, nce ntshav siab, palpitations, mob hauv siab.

Ntawm ib feem ntawm cov kev kuaj sim: qhov txo qis hauv prothrombin theem, kev nce amylase kev ua ub no.

Los ntawm cov kab mob hemopoietic: leukopenia, eosinophilia, thrombocytosis, thrombocytopenia, mob ntshav liab.

Los ntawm cov leeg musculoskeletal: mob rov qab, mob pob txha, mob myalgia.

Los ntawm cov kab ke ua haujlwm: chaw mos candidiasis, chaw mos.

Kev ua xua rau: xoo pob, khaus, urticaria.

Kev sib txuam

Nrog rau kev siv cov tshuaj tiv thaiv ib puag ncig, cov tshuaj ntxhia, multivitamins tsis hnov ​​lus zoo (vim kev tsim cov chelate ntau nrog polyvalent cations) thiab txo qhov kev cia siab ntawm cov tshuaj hauv plasma (kev tswj hwm ib txhij yog ua tau nrog lub sijhawm 4 teev ua ntej lossis 2 teev tom qab noj tshuaj).

Hauv kev kho nrog cov tshuaj thaum lwm cov tshuaj fluoroquinolones siv, kev txhim kho ntawm phototoxic tsis taus yog ua tau.

Ranitidine txo qis kev nqus ntawm cov tshuaj.

Cov lus nug, lus teb, tshuaj xyuas ntawm cov tshuaj Rotomox

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Yuav siv cov tshuaj Rotomox 400 li cas?

Rotomox 400 yog pab pawg ntawm cov tshuaj tua kabmob. Qhov no yog ib-tshuaj tiv thaiv. Cov ntsiav tshuaj yog coated kom qeeb los ntawm kev tso tawm ntawm cov tshuaj nquag. Cov tshuaj muaj txiaj ntsig zoo hauv kev tawm tsam cov kab mob phem, uas yog tus cwj pwm los ntawm kev tawm tsam qee yam tshuaj tua kab mob, piv txwv li, macrolides. Hauv kev tsim cov tshuaj, ntau npaum ntawm cov tshuaj nquag (400 mg) tau muab zais.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj yog tsim nyob rau hauv daim ntawv. Cov ntsiav tshuaj muaj 400 mg ntawm cov tshuaj nquag. Hauv lub peev xwm no, moxifloxacin ua. Cov tshuaj kuj tseem muaj lwm cov khoom siv, txawm li cas los xij, lawv tsis qhia cov haujlwm antibacterial, tab sis siv los tsim cov tshuaj ntawm qhov xav ua kom sib xws. Cov no suav nrog:

• pob kws nplej siab
• microcrystalline cellulose,
• sodium methyl parahydroxybenzoate,
• talcum hmoov
• magnesium stearate,
• silica colloidal
• sodium carboxymethyl hmoov txhuv nplej siab.

Cov tshuaj muaj nyob rau hauv pob nrog 5 pcs. ntsiav tshuaj.

Yuav siv cov moxifloxacin rau cov ntshav qab zib li cas?

Cov Tshuaj Pharmacokinetics

Cov tshuaj nquag hauv cov tshuaj muaj pes tsawg leeg yog nqus tau nrawm. Ntxiv mus, qhov khoom tivthaiv no yog qhov cuam tshuam txhua yam. Cov theem siv ntawm cov txheej txheem no tsis txo thaum noj mov. Qhov zoo ntawm cov tshuaj muaj xws li high bioavailability (ncav 90%). Cov tshuaj nquag khi rau cov protein nyob hauv ntshav. Qhov nyiaj moxifloxacin tsis ntau tshaj 40% ntawm tag nrho cov kev xav yog koom nrog hauv txoj haujlwm no.

Lub ncov ntawm kev ua tau tiav ob peb teev tom qab ib zaug ntawm koob tshuaj. Kev kho mob siab tshaj plaws tau pom ntawm 3 hnub tom qab pib kho mob. Cov tshuaj ua kom nquag tau faib thoob plaws lub cev, tab sis kom ntau dua nyob rau hauv cov ntsws, ntsws, txhaws. Hauv kev ua tiav ntawm cov metabolism, cov xoos tsis ua haujlwm raug tso tawm. Moxifloxacin tsis hloov pauv thiab cov metabolites raug ntaws los ntawm lub raum thaum tso zis thiab tso quav. Cov tshuaj sib npaug zoo rau kev kho poj niam thiab tus txiv neej.

Cov theem siv ntawm cov txheej txheem no tsis txo thaum noj mov.

Kev ntsuas rau siv

Muab hais tias cov tshuaj nquag khaws cia rau ntau dua hauv lub ntsws, bronchi thiab sinuses, Rotomax muab cov txiaj ntsig zoo tshaj plaws hauv kev kho mob ntsws nruab nrog. Txawm li cas los xij, cov yeeb tshuaj tuaj yeem ua tiav muaj txiaj ntsig zoo nyob rau hauv kev kho mob ntawm lwm yam kab mob pathological. Kev taw qhia rau kev siv:

• mob ntsws ntev nrog exacerbation,
• mob ntsws (cov tshuaj yog kws kho thaum kho mob sab nrauv lossis hauv tsev),
• cov kab mob ntawm lub plab hu ua provoked los ntawm teeb meem microorganisms (cov tshuaj yog tshuaj yog tias tsis muaj teeb meem),
• kis ntawm daim tawv nqaij thiab cov nqaij mos,
• mob sinusitis
• muaj teeb meem mob plab heev.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dosage cov ntaub ntawv ntawm moxifloxacin:

• cov yeeb yaj kiab-cov ntsiav tshuaj: biconvex, nyob ntawm tus tsim khoom: cov tshuaj ntsiav, zoo nkauj, los ntawm txiv kab ntxwv daj mus rau liab dawb, sau nrog "80" ntawm ib sab thiab "Kuv" nyob rau lwm qhov, lossis puag ncig daj hauv txhua cov ntsiav tshuaj hauv cov tshooj hla - qhov tseem ceeb yog los ntawm daj ntseg daj mus rau daj (5, 7 lossis 10 daim ib lub hlwv, hauv pob ntawv qhwv ntawm 1, 2 lossis 3 hlwv, 5, 7, 10 lossis 15 pieces hauv ib lub hlwv, hauv duab los qhia ib pob ntawm 1-6 pob khoom, 10 daim ib qho me me hauv lub hnab yas, hauv ib pob duab ntawv ntawm 1 tau),,
• Txoj kev daws teeb meem: ntshiab, daj daj rau ntsuab daj kua (50 ml txhua lub xim tsis muaj vials iav, 5 vials hauv ib daim ntawv qhia cardboard, 250 ml hauv lub hwj yas, hauv ib daim ntawv qhwv ib pob 1 lub raj hauv lossis tsis muaj lub hnab ntim hermetically kaw) nws, rau tsev kho mob - 1-96 fwj tsis muaj pob khoom hauv hnab ntim quav los yog tsis muaj lawv hauv thawv ntawv thawv).

1 ntsiav tshuaj muaj:

• cov tshuaj nquag: moxifloxacin hydrochloride - 436.4 mg (sib haum rau cov ntsiab lus ntawm moxifloxacin - 400 mg),
• cov khoom siv ntxiv: povidone K29 / 32 lossis K-30 (Kollidon 30), microcrystalline cellulose, magnesium stearate, croscarmellose sodium, nyob ntawm qhov chaw tsim khoom, ntxiv - lactose monohydrate, talc thiab silicon dioxide colloidal,
• zaj duab xis txheej (nyob ntawm tus tsim): Opadry II txiv kab ntxwv 85F23452 polyvinyl cawv, titanium dioxide, macrogol, talc, hnub poob daj zas xim nrog kua roj vanish (E110), hlau oxide zas xim liab (E172) lossis opadray liab 02F540000 hypromellose 2910, titanium dioxide (E171), macrogol, hlau oxide zas xim liab (E172), hlau oxide zas xim daj (E172) lossis qhuav sib xyaw rau zaj duab xis txheej ntawm hypromellose, hlau oxide daj (hlau oxide), hyprolose (hydroxypropyl cellulose), titanium dioxide, talc.

Hauv 1 ml ntawm kev daws rau Txoj kev lis ntshav muaj:

• cov tshuaj nquag: moxifloxacin hydrochloride - 1.744 mg (hauv moxifloxacin lub hauv paus - 1.6 mg),
• cov khoom siv ntxiv: sodium chloride, dej rau kev txhaj tshuaj, sodium hydroxide tov lossis hydrochloric acid tov, lossis (nyob ntawm tus tsim khoom lag luam) disodium ntsev ntawm ethylenediaminetetraacetic acid (sodium hydroxide tov lossis hydrochloric acid tov - siv yog tias tsim nyog yuav kho tus nqi pH hauv txoj kev).

Dosage daim ntawv

Cov ntsiav tshuaj-yeeb yaj kiab, 400 mg

Ib ntsiav tshuaj muaj

cov tshuaj heev - moxifloxacin hydrochloride 436.322 mg (sib npaug rau moxifloxacin 400.00 mg),

tus zam: pob kws hmoov txhuv nplej siab, microcrystalline cellulose, sodium starch glycolate, sodium methylhydroxybenzoate, colloidal silicon dioxide, talc, magnesium stearate

plhaub muaj pes tsawg leeg: Opadry paj yeeb 85F540146 (polyvinyl cawv, titanium dioxide (E171), macrogol, talc, hlau oxide liab (E172).

Cov ntsiav tshuaj yog cov xim thaij-yeeb yaj kiab, uas muaj kev pheej hmoo ntawm ib sab.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, moxifloxacin yog nqus sai thiab yuav luag txhua yam. Kev tsis raug cai ntawm qhov tsis raug cai yog txog 91%.

Tom qab txhaj ib koob tshuaj 400 mg ntawm moxifloxacin, qhov siab tshaj plaws (Cmax) hauv cov ntshav tau ncav cuag li 0.5-4 teev thiab yog 3.1 mg / l.

Peak thiab yam tsawg kawg ntshav ntshav ntau nyob hauv lub xeev ruaj khov (400 mg ib hnub ib zaug) yog 3.2 thiab 0.6 mg / L, raws. Hauv lub xeev ruaj khov, kev sib kis ntawm cov tshuaj thaum lub sijhawm sib txawv ntawm cov koob tshuaj yog kwv yees li 30% siab dua li tom qab txhaj thawj koob.

Moxifloxacin tau faib nrawm rau hauv qhov chaw seem, tom qab noj 400 mg ntawm cov tshuaj, thaj chaw hauv qab txoj kab txiav pharmacokinetic (AUC) yog 35 mg / h / L. Qhov sib faib khoom ntim kom sib npaug (Vss) yog kwv yees li 2 L / kg. Hauv kev tshawb fawb hauv vitro thiab hauv vivo, txoj kev khi ntawm moxifloxacin mus rau cov ntshav plasma yog 40-42%, tsis hais txog qhov tshuaj ntawm cov tshuaj. Moxifloxacin feem ntau khi rau cov ntshav dej albumin.

Cov kev ncov siab kawg hauv qab no (lub ntsiab lus geometric) tau pom tom qab kev tswj hwm ntawm ib qhov ncauj ntawm moxifloxacin, 400 mg:

Npuag

Kev Sau Ntawv

Qhov sib piv ntawm cov concentration ntawm cov tshuaj hauv cov ntaub so ntswg rau nws cov concentration hauv ntshav

Epithelial Lining Kua

Kev tsis haum xeeb ntawm Ethmoid

Poj niam lub paum

* tso ntshav siv tshuaj ib koob tshuaj 400 mg

1 10 teev tom qab kev tswj hwm tshuaj

2 concentration ntawm cov tshuaj dawb

3 ntawm 3 teev txog 36 teev tom qab kev tswj hwm

4 kawg ntawm Txoj kev lis ntshav

Moxifloxacin yauv raug biotransformation ntawm theem ob thiab raug nteg tawm los ntawm lub raum thiab lub plab hnyuv plab hauv daim ntawv uas tsis hloov pauv, nrog rau daim ntawv sulfo compound (M1) thiab glucuronide (M2). Cov metabolites no muaj feem xyuam rau tib neeg lub cev thiab tsis muaj cov haujlwm antimicrobial. Kev kawm txog kev sib cuam tshuam ntawm cov tshuaj pharmacokinetic nrog lwm cov tshuaj tau pom tias moxifloxacin tsis yauv biotransformation los ntawm microsomal cytochrome P450 system. Qhov ntsuas pom ntawm oxidative metabolism qhaj yog tsis tuaj.

Ib nrab-lub neej ntawm cov tshuaj los ntawm cov ntshav yog kwv yees li 12 teev. Qhov nruab nrab tag nrho kev tshem tawm tom qab noj ib koob ntawm 400 mg yog los ntawm 179 txog 246 ml / min. Kev hlais hlais tawm tshiab, kwv yees li 24-53 ml / min, tshwm sim los ntawm ib nrab ntawm cov leeg lub raj tshuaj rau hauv lub raum.

Kev siv tshuaj sib xyaw nrog ranitidine thiab probenecid tsis cuam tshuam rau lub raum uas tshem tawm cov tshuaj.

Tsis hais txog txoj kev ntawm txoj kev tswj hwm, pib cov khoom siv moxifloxacin yuav luag tiav 96-98% kev hloov pauv rau cov tshuaj tiv thaiv ntawm theem ob ntawm cov metabolism tsis muaj cov cim ntawm oxidative metabolism.

Pharmacokinetics hauv ntau pab pawg neeg mob

Cov neeg tuaj yeem noj qab haus huv nrog lub cev nyhav tsawg (piv txwv li poj niam) thiab cov laus neeg ua haujlwm pab pawg neeg muaj ntshav ntau dua ntawm cov tshuaj.

Cov chaw muag tshuaj ntawm moxifloxacin tsis txawv ntau hauv cov neeg mob uas lub raum tsis ua haujlwm (suav nrog kev tshem tawm creatinine> 20 ml / min / 1.73 m2). Nrog kev txo qis hauv kev ua haujlwm hauv lub raum, qhov kev cia siab ntawm metabolite M2 (glucuronide) nce ntxiv ntawm qhov feem ntawm 2.5 (nrog creatinine tshem tawm 50% hauv ib lossis ntau lub tebchaws.

Tsuas tshuaj thiab tswj hwm

Qhov pom zoo muab tshuaj yog 400 mg ib zaug ib hnub (250 ml ntawm kev daws rau Txoj kev lis ntshav). Tsis pub tshaj qhov pom zoo koob tshuaj.

Thaum pib theem pib ntawm kev kho mob, ib qho kev daws teeb meem rau Txoj kev lis ntshav tuaj yeem siv, thiab tom qab ntawd, los txuas ntxiv txoj kev kho, yog tias muaj kev qhia soj ntsuam, cov tshuaj tuaj yeem siv tshuaj hauv qhov ncauj.

Kev mob ntsws los ntawm zej zog - qhov pom zoo tag nrho kev kho mob rau kev kho qib (kev kho mob raws qhov ncauj los ntawm kev kho lub qhov ncauj) yog 7-14 hnub.

Cov tawv nqaij ua mob thiab cov nqaij mos mos - tag nrho lub sijhawm ntawm kev kho mob ntawm kauj ruam kev kho mob (tso ntshav raws qab los ntawm kev kho mob ncauj) yog 7-21 hnub.

Tsis pub tshaj qhov pom zoo ntawm lub sijhawm kho mob.

Menyuam yaus thiab tub ntxhais hluas

Moxifloxacin yog sib kis rau cov menyuam yaus thiab cov hluas. Qhov ua tau zoo thiab kev nyab xeeb ntawm moxifloxacin hauv cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo tsis tau tsim tsa.

Cov neeg laus cov neeg mob

Hloov txoj kev noj tshuaj ntxiv rau hauv cov neeg laus yog tsis xav tau.

Yuav tsum tsis txhob hloov pauv kev noj tshuaj nyob hauv cov haiv neeg pawg

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Muaj cov ntaub ntawv tsis txaus ntawm kev siv rau hauv cov neeg mob uas muaj lub siab ua haujlwm tsis zoo.

Cov neeg mob uas muaj lub cev tsis taus pplooj

Hauv cov neeg mob uas lub raum tsis ua haujlwm (suav nrog kev tshem tawm creatinine 5 zaug ntau dua qhov tsis pub dhau).

Cov tshuaj sib cuam tshuam

Kev sib cuam tshuam txog yeeb tshuaj

Qhov ua tau ntxiv cov txiaj ntsig ntawm qhov ntev QT ncua yuav tsum raug txiav txim siab thaum noj moxifloxacin thiab lwm yam tshuaj uas tuaj yeem ncua sijhawm QTc. Vim tias kev siv tshuaj moxifloxacin thiab cov tshuaj uas cuam tshuam nrog QT ncua, qhov pheej hmoo ntawm kev tsim ventricular arrhythmias, suav nrog polymorphic ventricular tachycardia (torsade de pointes), tau nce.

Txuag siv moxifloxacin nrog rau ib qho ntawm cov tshuaj hauv qab no yog contraindicated:

- Chav kawm IA tshuaj tiv thaiv kev ua kom tsis haum (xws li, quinidine, hydroquinidine, disopyramide)

- Qeb III cov tshuaj tiv thaiv kev ua kom tsis zoo (xws li, amiodarone, sotalol, dofetilide, ibutilide)

tshuaj tiv thaiv kev mob hlwb (xws li phenothiazines, pimozide, sertindole, haloperidol, sultoprid)

- qee cov tshuaj tua kabmob (saquinavir, sparfloxacin, iv erythromycin, pentamidine, antimalarials, tshwj xeeb hauv halofantrine)

- Qee cov tshuaj antihistamines (terfenadine, astemizole, misolastine)

- lwm tus (cisapride, vincamine iv, bepridil, diphemanil).

Moxifloxacin yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas noj cov tshuaj potassium-txo qis (piv txwv, lub voj thiab thiazide diuretics, laxatives, enemas (hauv kev txhaj tshuaj ntau), corticosteroids, amphotericin B) lossis tshuaj uas cuam tshuam nrog hauv kev kho mob tseem ceeb hauv bradycardia. Lub sijhawm nruab nrab ntawm kev noj cov tshuaj npaj muaj divalent lossis trivalent cations (piv txwv li, antacids muaj cov tshuaj magnesium lossis aluminium, didanosine ntsiav tshuaj, kev ua tiav ntawm tes thiab npaj muaj hlau lossis zinc) thiab moxifloxacin yuav tsum txog 6 teev.

Thaum rov qab noj dua ntawm moxifloxacin tau muab rau cov neeg ua haujlwm pub dawb noj qab haus huv, qhov siab tshaj plaws (Cmax) ntawm digoxin nce ntxiv kwv yees li 30%, thaum thaj chaw hauv qab nkhaus-sijhawm nkhaus (AUC) thiab qhov tsawg kawg nkaus concentration (Cmin) ntawm digoxin tsis hloov.

Cov txiaj ntsig ntawm kev tshawb nrhiav los ntawm cov neeg ua haujlwm pab dawb nrog cov ntshav qab zib mellitus pom tias nrog kev sib xyaw ua ke ntawm lub qhov ncauj ntawm moxifloxacin thiab glibenclamide, cov ntsiab lus ntawm glibenclamide hauv cov ntshav plasma poob qis los ntawm kwv yees li 21%, uas yog qhov kev tshawb fawb tuaj yeem ua rau txoj kev txhim kho ntawm cov mob sib kis ntev ntawm hyperglycemia. Txawm li cas los xij, cov kev hloov pauv ntawm cov kws kho mob tsis tau ua rau muaj kev hloov pauv hauv cov qauv pharmacodynamic (ntshav qabzib, insulin).

Hloov pauv hauv INR (kev sib txig ib txwm muaj thoob ntiaj teb)

Hauv cov neeg mob uas tau txais cov tshuaj anticoagulants ua ke nrog cov tshuaj tiv thaiv kab mob (tshwj xeeb yog fluoroquinolones, macrolides, tetracyclines, cotrimoxazole thiab qee cov cephalosporins), muaj cov xwm txheej ntawm cov tshuaj tiv thaiv anticoagulant ntau ntxiv. Cov mob txaus ntshai yog qhov tshwm sim ntawm ib qho kev kis tus kab mob (thiab cov txheej txheem ua paug), lub hnub nyoog thiab cov kab mob ntawm tus neeg mob. Hauv qhov no, nws nyuaj rau kev ntsuam xyuas seb puas muaj kev kis kab mob lossis kev kho mob ua rau ua txhaum cai ntawm INR. Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam tas li ntawm INR thiab, yog tias tsim nyog, hloov cov koob tshuaj ntawm cov tshuaj tiv thaiv qhov ncauj.

Cov kev tshawb fawb soj ntsuam tau pom tias tsis muaj kev cuam tshuam nrog kev siv moxifloxacin thiab cov tshuaj nram qab no: ranitidine, probenicide, tshuaj tiv thaiv qhov ncauj, tshuaj calcium uas muaj cov tshuaj ntxiv, morphine rau kev siv niam txiv, theophylline, cyclosporine lossis itraconazole.

Hauv kev tshawb fawb hauv vitro nrog tib neeg cytochrome P450 cov enzymes paub meej tias qhov kev tshawb pom no. Muab cov txiaj ntsig no, nws muaj peev xwm xaus lus tias kev sib cuam tshuam ntawm metabolic cuam tshuam nrog cytochrome P450 enzymes tsis zoo li.

Kev sib txuam khoom noj khoom haus

Moxifloxacin tsis muaj qhov sib cuam tshuam los ntawm kev kho mob nrog zaub mov, suav nrog cov khoom noj siv mis.

Cov kev daws teebmeem nram qab no tsis sib xws nrog moxifloxacin tov: sodium chloride tov 10% thiab 20%, sodium bicarbonate daws 4.2% thiab 8.4%.

Cov lus qhia tshwj xeeb

Qhov txiaj ntsig ntawm kev kho mob nrog moxifloxacin, tshwj xeeb tshaj yog mob me me mus rau mob sib kis, yuav tsum muaj qhov sib luag nrog cov ntaub ntawv muaj nyob hauv ntu no.

Lub sijhawm ntev ntawm QTc ncua thiab chaw kuaj mob uas cuam tshuam nrog lub sijhawm ntev ntawm QTc ntu

Nws tau tsim tsa uas moxifloxacin ncua sijhawm QTc ntu ntawm electrocardiograms ntawm qee tus neeg mob. Qib ntev ntawm QT ua kom ntev ntxiv nrog rau cov tshuaj muaj zog ntxiv nyob rau hauv cov ntshav ntshav vim kev tso ntshav sai sai. Yog li ntawd, lub sijhawm ua haujlwm ntawm kev lis ntshav yuav tsum yog tsawg kawg yog pom zoo 60 feeb yam tsis muaj ntau tshaj li qhov koob tshuaj ntawm 400 mg ib zaug ib hnub.

Txij li thaum cov poj niam feem ntau nyiam ua kom ntev QTc ntu piv rau txiv neej, lawv yuav muaj kev nkag siab ntau dua rau cov tshuaj uas txuas ntxiv QTc ntu. Cov neeg mob rau cov neeg laus kuj tseem tuaj yeem xav txog cov tshuaj uas txuas ntxiv QT ntu ib zaug.

Cov tshuaj uas tuaj yeem txo cov poov tshuaj yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas tau txais moxifloxacin.

Moxifloxacin yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj lub cev tsis haum (tshwj xeeb tshaj yog cov poj niam thiab cov neeg laus laus), xws li mob myocardial ischemia lossis ncua ntev ntawm QT ntu, vim tias qhov no tuaj yeem ua rau muaj kev pheej hmoo ntawm ventricular arrhythmias (suav nrog pirouette tachycardia) thiab mob plawv. Qib ntev ntawm kev QT ncua sij hawm tuaj yeem nce ntxiv nrog qhov nce ntxiv ntawm qhov tshuaj. Yog li, tsis txhob siab tshaj koob tshuaj pom zoo.

Yog tias muaj cov cim ntawm kev mob plawv dhia tsis xwm yeem hauv kev kho mob, koj yuav tsum tsis txhob noj cov tshuaj thiab ua ECG.

Kev tiv thaiv tsis haum thiab kev ua xua yog tau sau tseg tom qab thawj zaug muab tshuaj fluoroquinolones, suav nrog moxifloxacin.

Tsis tshua muaj teeb meem, kev siv tshuaj tiv thaiv kab mob tuaj yeem hloov mus rau txoj sia muaj kev kub ntxhov anaphylactic, hauv qee kis tom qab siv thawj zaug ntawm cov tshuaj. Hauv cov rooj plaub no, kev tswj hwm ntawm moxifloxacin yuav tsum tau txiav tawm thiab qhov tsim nyog kho mob (suav nrog kev tiv thaiv tsis txaus) yuav tsum tau ua.

Kev siv cov tshuaj quinolone cuam tshuam nrog kev pheej hmoo ntawm kev txhim kho qhov chua leeg. Ceev faj yuav tsum tau siv rau hauv cov neeg mob mob hauv nruab nrab lub paj hlwb tsis zoo, lossis nyob rau ntawm lwm qhov kev pheej hmoo uas yuav ua rau qaug dab peg lossis qis dua qhov cuam tshuam. Thaum muaj kev chua leeg, kev tswj hwm ntawm moxifloxacin yuav tsum tau txiav tawm thiab kev kho mob tsim nyog.

Cov xwm txheej ntawm cov pa roj los yog sensorimotor polyneuropathy tau tshaj tawm, ua rau mob paresthesia, hypesthesia, dysesthesia, lossis tsis muaj zog ntawm cov neeg mob uas tau txais quinolones, suav nrog moxifloxacin. Thaum muaj cov tsos mob ntawm kev mob neuropathy, xws li mob, kub hnyiab, ntxais caj dab, ua kom loog lossis tsis muaj zog, cov neeg mob noj moxifloxacin yuav tsum sab laj nrog kws kho mob ua ntej yuav kho ntxiv.

Cov kev xav hauv lub cev tuaj yeem tshwm sim txawm tias tom qab siv thawj zaug ntawm quinolones, suav nrog moxifloxacin. Hauv qee qhov tsis tshua muaj, kev nyuaj siab lossis kev xav ntawm lub siab xav mus rau kev xav tua tus kheej thiab tus cwj pwm nrog tus nyiam rau nws tus kheej, xws li kev tua tus kheej. Yog tias tus neeg mob tsim muaj cov tshuaj tiv thaiv, moxifloxacin yuav tsum tsis ua ntxiv thiab muab kev ntsuas tsim nyog. Nws raug nquahu kom muaj kev xyuam xim tshwj xeeb tshaj yog thaum sau ntawv moxifloxacin rau cov neeg mob hlwb lossis cov neeg mob uas muaj keeb kwm ntawm kev mob hlwb.

Thaum siv moxifloxacin, cov xwm txheej ntawm kev loj hlob ntawm tus mob muaj kab mob siab ntau, uas tuaj yeem ua rau tuag tau daim siab ua rau lub siab, suav nrog kev ua kom tuag taus, tau hais qhia. Cov neeg mob yuav tsum tau sab laj nrog kws kho mob ua ntej kev kho mob txuas ntxiv yog tias muaj cov tsos mob ntawm tus mob muaj kab mob siab ntau, xws li kev loj hlob sai ntawm kev mob ntsig txog mob txhaws qa, tso zis tsaus nti, ib qho nyiam los ntshav, lossis mob rau daim tawv nqaij txha caj qaum. Yog tias pom tshwm sim ntawm daim siab ua haujlwm, yuav tsum kawm txog lub siab ua haujlwm.

Cov neeg muaj mob rau cov tawv nqaij tawv nqaij piv txwv, piv txwv li Stevens-Johnson syndrome lossis mob ua paug lom (muaj feem ua rau tuag taus), tau tshaj tawm. Yog tias kev tawm tsam los ntawm daim tawv nqaij thiab / lossis cov xoos xoos pom, koj yuav tsum sab laj nrog kws kho mob ua ntej kev kho mob txuas ntxiv.

Tshuaj tua kabmob raws plab (AAD) thiab tshuaj tua kab mob sib kis (AAK), suav nrog rau mob plab ua paug thiab Clostridium difficile-Rov mob raws plab tau tshaj tawm txog kev siv cov tshuaj tiv thaiv kab mob ntau yam, suav nrog moxifloxacin, thiab tuaj yeem sib txawv ntawm qhov mob raws plab me mus rau mob plab tuag. Yog li, nws yog ib qho tseem ceeb uas yuav tsum ua kom txoj kev kuaj mob no rau hauv cov neeg mob uas mob plab zawv ntau thaum lossis tom qab noj moxifloxacin. Yog tias AAAD lossis AAK raug xoom xaim lossis kev lees paub, nws yog ib qho tsim nyog yuav tsum tsis txhob noj tshuaj tiv thaiv kab mob, nrog rau moxifloxacin, thiab sau ntawv kho mob kom tsim nyog. Ntxiv rau, kev tswj hwm kev tiv thaiv tsim nyog yuav tsum tau ua kom txo qis kev kis tus mob. Cov neeg mob uas tau mob zawv plab ntau yog contraindicated nyob rau hauv cov tshuaj uas inhibit plab hnyuv motility.

Moxifloxacin yuav tsum tau siv nrog ceev faj hauv cov neeg mob myasthenia gravis, vim tias cov tshuaj yuav ua rau cov tsos mob ntawm tus kab mob no hnyav dua.

Kev mob o thiab mob ntawm cov leeg (tshwj xeeb tshaj yog cov Achilles leeg), qee zaum ob sab sib luag, tuaj yeem tshwm sim thaum kho mob nrog quinolones, suav nrog moxifloxacin, txawm tias nyob hauv 48 teev tom qab pib kho, thiab kis tus mob tau tshaj tawm li ob peb hlis tom qab tsis kho kev kho. Kev pheej hmoo ntawm cov leeg mob thiab leeg pob txha caj qaum yog nce ntxiv hauv cov neeg mob laus thiab cov neeg mob kho nrog corticosteroids tib lub sijhawm. Ntawm thawj lub cim ntawm kev hnov ​​mob los yog mob, cov neeg mob yuav tsum tsis txhob noj moxifloxacin, daws qhov mob ntawm ceg tawv thiab tam sim ntawd sab laj tus kws kho mob kom tau txais kev kho mob uas tsim nyog (piv txwv li immobilization).

Thaum siv quinolones, kev tsis haum tshuaj lub ntsej muag raug sau tseg. Txawm li cas los xij, kev tshawb fawb pom tau tias moxifloxacin muaj qhov pheej hmoo tsawg dua ntawm qhov kev ntxim hlub me. Txawm li cas los xij, cov neeg mob yuav tsum zam kom tsis txhob raug UV hluav taws xob lossis hnub ci ncaj qha thaum kho nrog moxifloxacin.

Moxifloxacin tsis pom zoo rau kev kho mob los ntawm kev kis mob los ntawm kev tiv thaiv kab mob-ntawm cov kab mob Staphylococcus aureus (MRSA). Thaum pom tias muaj kab mob los yog paub tseeb tias muaj mob los ntawm methicillin-resistant staphylococcus, nws yog ib qho tsim nyog yuav tsum tau sau ntawv kho nrog ib qho tshuaj tiv thaiv uas tsim nyog.

Lub peev xwm ntawm moxifloxacin rau kev tiv thaiv qhov kev loj hlob ntawm mycobacteria tuaj yeem cuam tshuam cov txiaj ntsig ntawm kev sim Mycobacterium spp., ua rau muaj qhov tsis zoo tshwm sim thaum tshuaj ntsuam cov neeg mob cov qauv uas tau kho nrog moxifloxacin nyob rau lub sijhawm no.

Ib yam li lwm yam fluoroquinolones, kev siv moxifloxacin qhia txog kev hloov pauv hauv cov ntshav qabzib, nrog rau hypo- thiab hyperglycemia. Thaum siv tshuaj kho moxifloxacin, dysglycemia feem ntau tshwm sim rau cov neeg laus uas mob ntshav qab zib mellitus tau txais kev kho mob uas muaj cov tshuaj hypoglycemic hauv qhov ncauj (piv txwv li, sulfonylurea tshuaj) lossis insulin. Thaum kho cov neeg mob ntshav qab zib, ua tib zoo saib xyuas ntshav qabzib ntau dua yog pom zoo.

Moxifloxacin yuav tsum tau siv nrog ceev faj rau cov neeg laus cov neeg mob raum yog tias lawv tsis muaj peev xwm tswj cov dej txaus, vim lub cev qhuav dej tuaj yeem ua rau muaj kev pheej hmoo rau lub raum tsis ua haujlwm.

Nrog rau kev txhim kho qhov muag tsis pom kev zoo lossis lwm cov tsos mob ntawm lub qhov muag, koj yuav tsum tau sab laj ib tus kws kho qhov muag tam sim.

Cov neeg mob uas muaj keeb kwm tsev neeg los yog cov piam thaj tiag-6-phosphate dehydrogenase yog cov mob hemolytic ntau heev thaum kho nrog quinolones. Moxifloxacin yuav tsum muaj ntawv ceeb toom nrog ceev faj rau cov neeg mob no.

Moxifloxacin Txoj kev lis ntshav daws yog rau kev saib xyuas cov leeg ib leeg nkaus xwb. Kev tshawb nrhiav kab mob ua ntej pom tau muaj qhov tshwm sim ntawm tus mob periarterial o ntawm cov nqaij mos tom qab kev siv tshuaj moxifloxacin, yog li ntawd, txoj kev tswj hwm no yuav tsum raug zam.

Cev xeeb tub thiab lactation

Kev nyab xeeb ntawm kev noj moxifloxacin thaum cev xeeb tub hauv poj niam tsis tau txheeb xyuas. Cov kev tshawb fawb tsiaj tau pom tias muaj tshuaj lom neeg muaj tsiaj txhu. Peb paub tsis meej tias yuav muaj xwm txheej dabtsi rau tib neeg. Vim cov ntaub ntawv tshaj tawm txog kev puas tsuaj ntawm pob txha mos ntawm cov pob qij txha loj los ntawm fluoroquinolones hauv cov tsiaj ua ntej thiab thim rov qab kev sib koom tes tau piav qhia hauv cov menyuam yaus kho nrog qee fluoroquinolones, moxifloxacin yuav tsum tsis txhob raug rau cov poj niam cev xeeb tub.

Cov ntaub ntawv hais txog kev siv cov tshuaj rau cov poj niam lub sijhawm lactation tsis muaj. Kev tshawb fawb qhia paub tau pom tias moxifloxacin muaj tsawg mentsis yuav muab zais rau hauv niam cov kua mis. Kev siv moxifloxacin thaum lub sijhawm pub mis niam yog contraindicated.

Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav tsheb thiab lub phom sij phom sij.

Cov tshuaj yuav tuaj yeem ua kom tsis muaj peev xwm ntawm cov neeg mob tsav tsheb thiab koom nrog lwm yam kev phom sij uas yuav tsum tau saib xyuas kom sai thiab muaj kev puas siab puas ntsws psychomotor sai vim qhov cuam tshuam rau lub hauv nruab nrab lub paj hlwb thiab qhov muag tsis pom.

Noj ntau dhau

Muaj qee cov ntaub ntawv overdose muaj.

Yog tias muaj kev noj ntau dhau, ib qho yuav tsum tau ua los ntawm cov duab saib mob thiab ua cov tsos mob kom zoo nrog kev saib xyuas ECG. Kev siv cov pa roj carbon activated rau kev kho mob ntawm kev noj tshuaj ntau dhau ntawm qhov ncauj los yog infusion tswj hwm ntawm 400 mg ntawm moxifloxacin yuav tsim nyog los tiv thaiv kev tiv thaiv kev qog ntau dhau ntawm moxifloxacin ntau dua 80% lossis 20%, feem.

Chaw tsim tshuaj paus

Luam theej duab Biotech Limited, Is Nrias teb

Lub npe thiab lub teb chaws ntawm daim ntawv pov thawj rau npe tuav

Routec Limited, UK

Chaw nyob ntawm lub koom haum lees txais kev thov nyiaj los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo (cov khoom lag luam) thiab lub luag haujlwm rau kev tso npe tom qab tshuaj xyuas kev nyab xeeb tshuaj nyob hauv thaj chaw ntawm koom pheej ntawm Kazakhstan

St. Dosmukhametova, 89, lub chaw lag luam "Caspian", chaw haujlwm 238, Almaty, Koom pheej ntawm Kazakhstan.

Kev tshuaj xyuas txog cov tshuaj

Hauv yuav luag txhua qhov kev tshuaj xyuas tus neeg mob, Moxifloxacin ua tau zoo tiv thaiv tus neeg sawv cev ntawm tus kab mob thiab txhim kho txoj kev noj qab haus huv sai.

Txawm li cas los xij, ntau cov neeg tshuaj xyuas yws txog qee qhov kev mob tshwm sim tom qab siv cov tshuaj no. Ntawm lawv, cov lus hais feem ntau yog: xeev siab, raws plab, mob plab me, dias taub hau, mob hauv siab me ntsis, palpitations, mob taub hau, tachycardia, insomnia, ntxhov siab vim thiab kev nyuaj siab.

Qee tus neeg mob tau hais tias kev tshem tawm ntawm cov kev mob tshwm sim yog yoog los ntawm kev noj Moxifloxacin ntsiav tshuaj thaum noj mov thiab haus dej ntxhia ntau tom qab noj cov tshuaj.

Ntau txoj kev txheeb xyuas tau piav qhia tias kev noj cov tshuaj ua rau muaj kev tawm tsam hauv cov poj niam, uas tau yooj yim tshem tawm los ntawm kev noj Difluzole (lossis lwm yam tshuaj zoo sib xws).

Kev tshuaj xyuas ntawm Vigamox qhov muag rau feem ntau tsuas yog qhov zoo. Lawv tau pom zoo zoo los ntawm cov neeg mob thiab tsis ua rau muaj kev phiv. Cov kws sau ntawv ntawm kev tshuaj xyuas tau sau tseg sai sai ntawm kev tshem tawm qhov muag tsis xis nyob thiab cov tsos mob ntawm tus mob qis.

Kev tshuaj xyuas ntawm qhov tsis haum rau Vigamox tee yog qhov tsis tshua muaj tshwm sim. Hauv cov rooj plaub no, cov neeg mob tau sau tseg qhov pom ntawm khaus thiab liab liab ntawm lub qhov muag. Tom qab kev txiav tawm ntawm cov tshuaj, cov tsos mob no tau sai sai.

Feem ntau cov neeg mob teb rau tus nqi ntawm Moxifloxacin thiab nws cov analogues li "siab."

Tus nqi ntawm cov tshuaj hauv Lavxias thiab Ukraine

Tus nqi ntawm Moxifloxacin nyob ntawm daim ntawv tso tawm, chaw muag tshuaj thiab lub nroog muag cov tshuaj no. Ua ntej yuav nws, koj yuav tsum qhia meej nws tus nqi hauv ntau lub tsev muag tshuaj thiab sab laj nrog koj tus kws kho mob txog nws qhov kev hloov pauv nrog ib qho analogue, vim tias nws yog cov tshuaj no uas tsis tuaj yeem pom ntawm kev muag. Ntau zaus hauv cov khw muag tshuaj lawv muag cov lus sib piv (cov lus zoo) ntawm Moxifloxacin dua li cov tshuaj no nws tus kheej.

Tus nqi nruab nrab ntawm cov analogues (txhais tau) ntawm Moxifloxacin hauv khw muag tshuaj hauv Lavxias thiab Ukraine:

• Avelox kev daws teeb meem rau cov leeg ntshav 400 mg / 250 ml 1 lub raj mis - 1137-1345 rubles, 600-1066 hryvnias,
• Moxifloxacin-Farmex kev daws teeb meem rau cov leeg ntshav 400 mg / 250 ml 1 lub raj mis - 420-440 hryvnia,
• Cov tshuaj Maxicin rau kev tso ntshav hla dej 400 mg / 250 ml 1 lub raj mis - 266-285 hryvnia,
• Avelox ntsiav tshuaj 400 mg, 5 daim ib pob - 729-861 rubles, 280-443 hryvnias,
• Qhov muag Vigamox poob 0.5% 5 ml - 205-160 rubles, 69-120 hryvnias.

Cov Tshuaj Hauv Tshuaj

Moxifloxacin yog antimicrobial tshuaj ntawm fluoroquinolone pawg, uas muaj cov nyhuv bactericidal, cov tshuab ntawm uas yog vim yog inhibition ntawm cov kab mob enzymes topoisomerase II (DNA gyrase) thiab topoisomerase IV, uas tsim nyog rau kev rov ua dua, hloov thiab kho kho deoxyribonucleic acid (DNA), ua rau muaj kev cuam tshuam nrog kev tuag. hlwb.

Yam tsawg kawg ntawm cov kab mob feem ntau sib xws nrog nws qhov kev txwv qis tshaj plaws (MIC). Cov kev ua haujlwm tiv thaiv kab mob tsis muaj kev ntxhov siab los ntawm cov txheej txheem ua rau rov tshwm sim ntawm kev tawm tsam rau macrolides, aminoglycosides, cephalosporins, penicillins thiab tetracyclines. Tsis pom tus ntoo khaub lig-tiv thaiv tau pom nyob nruab nrab ntawm cov tshuaj tua kab mob thiab moxifloxacin, thiab tsis muaj ib qho tshwm sim ntawm plasmid tsis kam. Kev tawm tsam ntawm cov tshuaj nquag yuav maj mam dhau los ntawm ntau yam kev hloov. Tawm tsam keeb kwm yav dhau los ntawm kev rov ua dua ntawm cov tshuaj ntawm cov kab mob me me ntawm qhov ntau ntawm qis dua MIC, tsuas yog nce me ntsis hauv qhov ntsuas no tau pom.Cross-tsis kam mus rau quinolones tau pom, txawm li cas los xij, qee cov kab mob gram-positive thiab anaerobic nthuav qhia tsis kam mus rau lwm cov quinolones qhia rhiab rau moxifloxacin.

Hauv kev tshawb pom hauv vitro qhia txog kev ua tawm tsam ntau ntawm anaerobes, kab mob gram-tsis zoo thiab kab mob gram-zoo, cov kab mob atypical thiab kua qaub tiv taus, suav nrog xws li Legionella spp., Chlamydia spp., Mycoplasma spp. qhov kev txiav txim ntawm P-lactam thiab tshuaj tua kab mob macrolide.

Hauv ob txoj kev tshawb nrhiav los ntawm cov neeg ua haujlwm pub dawb, ua raws li kev tswj hwm qhov ncauj ntawm cov tshuaj, cov kev hloov pauv hauv cov hnyuv microflora tau pom: ib qho kev txo qis ntawm Bacteroides vulgatus, Bacillus spp., Escherichia coli, Klebsiella spp., Enterococcus spp., Ib yam li anaerobes Peptostreptococcus spp. Cov. thiab Bifidobacterium spp. Tus nqi ntawm cov kab mob me me rov mus nyob li qub hauv ob lub lis piam. Clostridium difficile co toxins tsis tau pom.

Hauv qab no yog cov kab mob me me nyob hauv qhov pom ntawm cov kab mob antibacterial ntawm moxifloxacin.

Cov kab mob ntawm cov kab mob hauv qab no yog rhiab rau qhov kev ua ntawm cov tshuaj:

• gram-negative aerobes: Haemophilus influenzae thiab Moraxella catarrhalis (suav nrog cov nqaij sib txuas ua ke thiab tsis ua ke nrog cov beta-lactamases) *, Haemophilus parainfluenzae *, Proteus vulgaris, Acinetobacter baumannii, Bordetella pertussis,
• Gram-positive aerobes: Gardnerella vaginalis, Streptococcus pneumoniae *, nrog rau cov leeg uas muaj ntau yam tshuaj tiv thaiv kab mob thiab cov kab mob uas pom tias muaj peev xwm tiv thaiv penicillin, nrog rau cov kab mob tawm tsam ua rau ob lossis ntau dua tshuaj tua kab mob, xws li penicillin (MIC ntau dua 2 μg / ml ), tetracyclines, cephalosporins thib ob (xws li cefuroxime), trimethoprim-sulfamethoxazole, macrolides, Streptococcus milleri (Streptococcus constellatus *, Streptococcus anginosus *, Streptococcus intermedius *), Streptococcus pyogen (pawg) A (pab pawg Streptococcus pyogen) (pab pawg Aptococcus pyogen) (pab pawg Aptococcus pyogenes)

Cov kab mob ntawm cov kab mob hauv qab no yog nruab nrab nkag mus rau moxifloxacin:

• gram-negative aerobes: Cov kab mob Enterobacter spp. (Cov kab mob Enterobacter sakazakii, Enterobacter intermedius, Enterobacter aerogenes), Citrobacter freundii **, Klebsiella pneumoniae *, Escherichia coli *, Klebsiella oxytoca, Pantoea agglomerans, Enterobacter cloacae *, Stenotrophomonas maltophiliaomomalomacomulomulomulomulomulomulomulus Providencia spp. (Providencia stuartii, Providencia rettgeri), Neisseria gonorrhoeae *,
• A-loj aerobes: Enterococcus faecium *, Enterococcus avium *, Enterococcus faecalis (tsuas yog mob rhiab rau gentamicin thiab vancomycin) *,
• anaerobes: Clostridium spp. *, Peptostreptococcus spp. *, Bacteroides spp. (Bacteroides vulgaris *, Bacteroides fragilis *, Bacteroides thetaiotaomicron *, Bacteroides distasonis *, Bacteroides uniformis *, Bacteroides ovatus *).

Cov kab mob me me hauv qab no tiv taus cov tshuaj: coagulase-negative Staphylococcus spp. (cov kab mob hu ua methicillin-resistant ntawm Staphylococcus cohnii, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus simureans)

* Cov kev nkag siab ntawm cov kab mob me me mus rau moxifloxacin yog kev paub tseeb los ntawm cov ntaub ntawv soj ntsuam.

** Kev siv tsis raug pom zoo rau kev kho mob ua mob los ntawm methicillin-resistant S. aureus leeg (MRSA). Yog tias nrhiav tus mob MRSA lawm lossis xav tias tsam mob, yuav siv cov tshuaj tua kab mob los kho rau.

Kev faib tawm ntawm cov tshuaj yuav kis rau qee hom yuav txawv nyob rau lub sijhawm thiab txawv ntawm thaj tsam thaj chaw. Thaum kuaj kab mob sib txawv, nws raug pom zoo kom muaj cov ntaub ntawv tiv thaiv hauv zos, uas yog qhov tshwj xeeb tshaj yog kev kho cov mob hnyav.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub, moxifloxacin txoj kev kho yog contraindicated vim tsis muaj cov ntaub ntawv soj ntsuam tshawb pom nws muaj kev nyab xeeb nyob rau lub sijhawm no. Hauv cov menyuam yaus noj qee cov quinolones, qhov mob ntawm kev rov qab sib koom ua ke tau raug sau tseg, tab sis tsis muaj ntaub ntawv qhia txog qhov tshwm sim ntawm tus kab mob no hauv menyuam hauv plab thaum siv los ntawm lawv niam thaum cev xeeb tub. Hauv kev tshawb nrhiav tsiaj, kev muaj menyuam yaus muaj tshuaj lom cov tshuaj tau pom, tab sis kev pheej hmoo rau tib neeg tsis tau tsim.

Txij li me moxifloxacin kis mus rau niam mis, thiab tsis muaj ntaub ntawv qhia txog kev siv cov mis pub mis, nws siv yog contraindicated thaum lactation.

Nrog lub siab ua haujlwm tsis zoo

Moxifloxacin yog contraindicated rau kev siv rau hauv chav kawm C mob siab rau kev ua haujlwm raws li kev faib menyuam yaus-Pugh, nrog rau kev hloov pauv transaminase ntau dua tsib zaug ntawm VGN, vim muaj cov ntaub ntawv kuaj mob tsawg. Thaum muaj kab mob siab, nws yog contraindicated yuav siv cov tshuaj lossis kev saib xyuas tshwj xeeb yuav tsum tau coj (nyob ntawm tus tsim khoom).

Hauv cov neeg mob uas muaj lub cev ua haujlwm tsis haum lub siab ntawm chav A thiab B ntawm Kev Siv Me Nyuam Pugh, tsis tas yuav hloov pauv cov tshuaj ntau npaum li cas ntawm moxifloxacin.

Yeeb tshuaj sib cuam tshuam

• tricyclic antidepressants, hydroquinidine, quinidine, disopyramide (chav kawm IA antiarrhythmics), ibutilide, dofetilide, sotalol, amiodarone (chav III antiarrhythmics), halofantrine (antimalarials), pentamidine, erythromycin (nrog ivx), sprylolof ), sultopride, haloperidol, sertindole, pimozide, phenothiazine (antipsychotics), misolastine, astemizole, terfenadine (antihistamines), diphemanil, bepridil, vincamine (nrog rau kev tswj hwm), cisapride thiab lwm yam tshuaj uas cuam tshuam elongation thiab Tervala QT: lawv neej coj siv rau cov moxifloxacin yog txhob vim aggravation ntawm txoj kev pheej hmoo ntawm ventricular arrhythmia (xws li ventricular tachycardia hom torsade de pointes ..),
• kev npaj muaj hlau, zinc, magnesium thiab aluminium, antacids, tshuaj tiv thaiv antiretroviral (didanosine), ua tiav tau zoo: ib qho tseem ceeb txo qis ntawm cov tshuaj moxifloxacin yog ua tau vim muaj kev tsim cov chelate nyuaj nrog ntau cov ntawv suav nrog lawv cov qauv, kev sib nrug ntawm kev noj cov tshuaj no thiab moxifloxacin yuav tsum yuav tsawg kawg 4 teev
• cov pa roj carbon activated: vim kev tiv thaiv tsis haum ntawm cov tshuaj tua kab mob, nws lub cev kev noj qab haus huv txo qis dua 80% (thaum noj ntawm qhov ncauj 400 mg),
• digoxin: tsis muaj qhov txawv txav ntawm qhov tsis muaj pharmacokinetic,
• warfarin: tsis muaj kev hloov pauv hauv lub sijhawm prothrombin thiab lwm yam kev ntsuas ntawm cov ntshav coagulation, txawm li cas los xij, muaj peev xwm nce qhov kev ua haujlwm ntawm cov tshuaj tiv thaiv kabmob, qhov kev pheej hmoo suav nrog kev kis kabmob, tus mob feem ntau thiab lub hnub nyoog ntawm tus neeg mob, nws yog qhov yuav tsum tau sojntsuam INR thiab, yog tias tsim nyog, hloov qhov ntau ntxiv ntawm cov tshuaj tiv thaiv tsis tau,
• cyclosporine, tshuaj ntxiv calcium, atenolol, theophylline, ranitidine, tshuaj tiv thaiv qhov ncauj, itraconazole, glibenclamide, morphine, digoxin, probenecid - tsis muaj kev sib cuam tshuam los ntawm cov tshuaj no nrog moxifloxacin tau kuaj (cov tshuaj pauv tsis tas yuav tsum tau),,
• sodium bicarbonate daws ntawm 4.2 thiab 8.4%, sodium chloride tov ntawm 10 thiab 20% - cov kev daws teeb meem no tsis sib xyaw nrog moxifloxacin infusion solution (tib lub sijhawm nws txwv tsis pub nkag).

Analogs ntawm moxifloxacin yog Vigamoks, Alvelon-MF Megafloks, Avelox, Moksigram, Maksifloks, Akvamoks, Moksistar, Moksiflo, Moksispenser, Moksimak, Moxifloxacin Sandoz, Moxifloxacin CHP Moxifloxacin Alvogen, Moflaksiya, Moxifloxacin STADA, Moxifloxacin Canon Moxifloxacin-Verein , Plevilox, Rotomox, Moxifur, Moxifloxacin-TL, Ultramox, Simoflox, Heinemox.