Angiopril - cov lus qhia rau kev siv

Lub npe thoob ntiaj teb - captopril

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm. Cov tshuaj yeeb tshuaj yog captopril. Ntsiav tshuaj 0.025 thiab 0.05 g, 10 pcs. hauv pob.

Kev siv cov tshuaj angiopril tsuas yog raws li kws kho mob tau hais tseg, cov lus qhia tau muab rau siv!

Koj puas xav kom koj noj qab nyob zoo? Caij tsheb kauj vab tsis tu ncua

Lus hais txog lub zeem muag uas peb tseem ntseeg

Tuag taus kab mob uas nyob rau hauv peb noj

Vim li cas koj thiaj li yuav tsum tau ntxuav koj txhais tes tom qab mus xyuas koj tus kheej chav dej?

Vim li cas nws tseem ceeb rau kev noj qab haus huv tsis ua kom tsis txhob kawm?

Grippol ® Quadrivalent: cov lus qhia, sib sau, kev txheeb xyuas txog kev txhaj tshuaj tiv thaiv khaub thuas

Dab tsi tuaj yeem ua tsis tau tom qab noj mov, kom tsis txhob muaj mob rau lub cev

Yuav kho tus mob caj pas: tshuaj lossis lwm txoj hauv kev?

Txog hnub lawm: puas yuav muaj kev cia siab thiab noj qab haus huv zoo dua tom qab 45 xyoos?

Lub Tsev Muag Khoom Nruab Nrab - Laser Tshem Tawm Plaub Hau thiab Pleev Tshuaj pleev ib ce hauv Ukraine

Peb kuj nyeem:

moschino hnab thawj ntawm no

Cov mob kas cees thiab mob tshwm sim hauv cov poj niam: nyeem ntxiv hauv cov kab lus hauv European Clinic.

Txwv tsis pub luam tawm lossis lwm yam kev faib tawm cov lus ntawm peb lub xaib yog txwv tsis pub. Luam tawm qhov "Cov Xov Xwm" tau tso cai yog tias muaj qhov txuas txuas rau MedicInform.Net qhib rau kev tshawb nrhiav cov tshuab

Cov ntaub ntawv rau ntawm lub xaib tau tshaj tawm cov laj thawj. Cov neeg kho pauv tsis suav nrog kev xav ntawm cov sau los ntawm cov khoom luam tawm. Ua ntej thov cov lus pom zoo, nws raug nquahu kom koj sab laj nrog koj tus kws kho mob!

Cov chaw muag tshuaj

Antihypertensive, vasodilator, cardioprotective, natriuretic. Nws inhibits ACE, txwv tsis pub hloov ntawm angiotensin I rau angiotensin II thiab tiv thaiv qhov tsis muaj peev xwm ntawm endogenous vasodilators. Cov nyhuv antihypertensive tshwm sim li 15-60 feeb tom qab kev tswj hwm ntawm qhov ncauj, nce mus txog qhov siab kawg tom qab 60-90 feeb thiab kav ntev li 6-12 teev .Nws txo lub plawv dhia, ua ntej- thiab tom qab ua rau lub siab, siab ntawm lub voj voog pulmonary thiab tsis kam ntawm cov hlab ntsws, ua rau lub plawv tawm mus ntxiv (HR) tsis hloov). Nws muaj cov nyhuv cardioprotective. Sai sai thiab kom meej yaim los ntawm cov hnyuv. Kev siv Sublingual txhim kho kev siv bioavailability thiab ua kom nrawm rau pib ntawm kev ua. Nws kis tau los ntawm cov kev txwv keeb kwm, tsis suav nrog BBB, dhau ntawm cov txiv neej thiab xa mus rau niam mis. Qhov kev tshem tawm ib nrab-lub neej ua rau 2-3 teev. Muaj feem ntau mob siab los ntawm lub raum.

Kev ntsuas rau siv

Arterial hypertension, suav nrog kho kom rov qab kho mob (mob me lossis qis tshaj li thawj cov tshuaj ntawm kev xaiv, mob hnyav yog tias cov qauv kev kho mob tsis muaj txiaj ntsig lossis tsis raug tiv thaiv tsis zoo), CHF (hauv kev kho ua ke), LV kev ua haujlwm tsis zoo tom qab myocardial infarction nyob rau hauv qhov chaw kho mob ruaj khov, ntshav qab zib nephropathy nrog hom 2 mob ntshav qab zib mellitus 1 (nrog albuminuria ntau tshaj 30 mg / hnub).

Cov Yuav Tsum Muaj

Cov tshuaj tiv thaiv tsis haum rau captopril lossis lwm yam tshuaj tiv thaiv ACE inhibitors, cev xeeb tub, lactation (hauv teb chaws Russia, cov tshuaj tsis pom zoo rau siv rau cov neeg muaj hnub nyoog qis dua 18 xyoo.) Kev ceeb toom. Keeb kwm ntawm mob hlwb thaum lub sij hawm kho nrog ACE inhibitors, kab mob siab los yog idiopathic angioedema, aortic stenosis, cerebrovascular thiab kab mob plawv (suav nrog cerebrovascular tsis txaus, mob plawv, mob tsis txaus), mob hnyav ntawm cov leeg mob ntawm cov nqaij sib txuas ( SLE, scleroderma), kev txwv tsis pub cov leeg pob txha hematopoiesis, mob ntshav qab zib mellitus, hyperkalemia, ob tog raum leeg mob stenosis, mob ntshav tawm ntawm ib lub raum artery, mob tom qab hloov raum, lub raum thiab / lossis daim siab ua haujlwm, kev noj zaub mov noj nrog kev txwv ntawm Na +, tej yam kev mob nrog BCC txo qis (suav nrog raws plab, ntuav), muaj hnub nyoog laus.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, 1 teev ua ntej noj mov, nrog mob ntshav ncig, kev kho mob pib nrog kev siv tshuaj qis dua 12,5 mg 2 zaug hauv ib hnub (tsis tshua muaj nrog 6.25 mg 2 zaug hauv ib hnub). Kev saib xyuas yuav tsum tau them rau qhov thev taus ntawm thawj koob thaum thawj teev. Yog tias txoj hlab ntshav hauv txoj hlab ntshav loj tuaj hauv qhov no, tus neeg mob yuav tsum tau tsiv mus rau qhov chaw tav toj (xws li qhov tshuaj tiv thaiv rau thawj koob yuav tsum tsis ua lub chaw khuam siab rau kev kho ntxiv). Nrog captopril monotherapy, qhov muaj txiaj ntsig zoo tuaj yeem tau los ntawm kev txiav txim siab ib txhij ntawm Na + hauv lub cev.

Nrog chav kawm ntawm kev kho mob, cov koob tshuaj, yog tias tsim nyog, tau nce ntxiv tom qab 2-4 lub lis piam, ntau li ntau tau - txog li 50 mg 3 zaug ib hnub. Hauv kev mob ntshav siab tshaj plaws (mob ntshav ntshav ntshav ntau npaum li 115 hli Hg lossis siab dua), feem ntau ua ke nrog lwm cov tshuaj tiv thaiv kabmob, feem ntau nrog thiazide diuretics (hydrochlorothiazide - 25-50 mg / hnub). Kev siv tshuaj diuretic tuaj yeem nce nrog lub sijhawm luv ntawm 1-2 lub lis piam kom txog thaum qhov ntau kawg siv nyob rau hauv kev kho mob tawg.

Kev saib xyuas cov koob tshuaj rau "mob me" thiab mob ntshav txhaws (cov ntshav siab - 95-114 hli Hg) yog 25 mg (qee zaum 12.5 mg) 2 zaug hauv ib hnub.

Hauv cov neeg laus cov neeg mob, thawj koob tshuaj yog 6.25 mg 2 zaug ib hnub.

Thaum lub plawv tsis ua haujlwm, nws yog cov tshuaj ua ke nrog diuretics thiab / lossis kev sib xyaw nrog digitalis npaj (yuav kom tsis txhob muaj qhov pib ntshav siab ntau dhau ua ntej cov tshuaj noj captopril, cov diuretic yog tso tseg lossis cov tshuaj txo). Thawj koob tshuaj yog 6.25 mg lossis 12.5 mg 3 zaug hauv ib hnub, yog tias tsim nyog, nce qhov koob rau 25 mg 3 zaug hauv ib hnub. Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 150 mg.

Thaum lub cev tsis ua haujlwm LV ua haujlwm tom qab raug mob myocardial infarction hauv cov neeg mob hauv lub xeev qhov chaw mob ruaj khov, captopril tuaj yeem pib ntxov li 3 hnub tom qab myocardial infarction. Thawj koob tshuaj yog 6.25 mg / hnub, tom qab ntawd lub koob tshuaj txhua hnub tuaj yeem nce ntxiv rau 37.5-75 mg nyob rau hauv 2-3 koob tshuaj (nyob ntawm kev kam ntawm cov tshuaj) txog ntau kawg yog 150 mg / hnub.

Nrog txoj kev loj hlob ntawm txoj hlab ntsha hypotension, koob tshuaj yuav tsum raug txo. Tom qab siv tshuaj kho qhov siab tshaj plaws txhua hnub ntawm 150 mg yuav tsum tau ua raws li kev cia siab rau captopril.

Hauv cov mob ntshav qab zib nephropathy, ib koob tshuaj 75-150 mg / hnub yog kho.

Nrog kev ua kom tiav ntawm qog ua kom lub raum tsis ua haujlwm (CC tsawg kawg 30 ml / min / 1.73 sq.m), captopril tuaj yeem kho nyob rau ntawm koob tshuaj 75-100 mg / hnub. Nrog kev tshaj tawm txog qhov ua rau lub raum ua haujlwm (CC tsawg dua 30 ml / min / 1.73 m), thawj koob yuav tsum tsis pub ntau tshaj 12,5 mg / hnub, tom qab ntawd, yog tias tsim nyog, koob tshuaj captopril yog maj mam nce dua ntawm cov sijhawm sib npaug, tab sis siv tsawg dua Nyob rau hauv cov ntaub ntawv ntawm kev kho mob ntawm arterial tawg, koob tshuaj txhua hnub.

Cov menyuam yaus (nyob rau hauv Russia siv hauv cov menyuam yaus tsis raug tso cai) yog tsuas yog rau cov mob ntshav siab tshaj plaws (nrog rau qhov tsis muaj txiaj ntsig ntawm lwm txoj kev kho) ntawm ib koob ntawm 0.1-0.4 mg / kg 2 zaug hauv ib hnub.

Cov menyuam yug tshiab - qhov pib txhaj tshuaj ntawm 0.01 mg / kg 2-3 zaug hauv ib hnub, cov menyuam loj dua - qhov pib ntawm 0.3 mg / kg 3 zaug hauv ib hnub, yog tias tsim nyog, nce qhov koob ntawm 0.3 mg / kg ntawm ncua sijhawm ntawm 8-24 teev kom tsawg kawg koob tshuaj Cov.

Pharmacological kev txiav txim

ACE inhibitor. Txo qhov tsim ntawm angiotensin II los ntawm angiotensin I. Txo cov ntsiab lus ntawm angiotensin II ua rau txo qis ncaj qha rau kev tso tawm ntawm aldosterone. Tib lub sijhawm, OPSS, ntshav siab, tom qab- thiab preload hauv lub siab yog txo qis. Nthuav cov hlab ntsha mus rau qhov ntau dua li cov leeg ntshav. Nws ua rau txo qis ntawm qhov kev tso tawm ntawm bradykinin (ib qho cuam tshuam ntawm ACE) thiab qhov nce ntawm cov synthesis ntawm Pg.

Cov nyhuv antihypertensive tsis yog nyob ntawm kev ua si ntawm plasma renin, qhov txo qis rau cov ntshav siab tau sau tseg ntawm ib txwm thiab txawm tias txo cov tshuaj hormones ntau, uas yog vim muaj cov nyhuv ntawm cov nqaij mos renin-angiotensin systems. Txhim kho txoj hlab ntshav siab thiab lub raum khiav ntshav.

Nrog rau siv ntev, nws txo qhov mob hnyav ntawm hypertrophy ntawm myocardium thiab phab ntsa ntawm cov hlab ntsha ntawm hom tiv thaiv. Txhim kho cov ntshav xa mus rau ischemic myocardium. Txo platelet aggregation. Pab txo Na + cov ntsiab lus hauv cov neeg mob lub plawv.

Ntawm kev txhaj tshuaj ntawm 50 mg / hnub, nws ua kom pom cov khoom angioprotective piv rau cov hlab ntsha ntawm microvasculature thiab tuaj yeem ua rau qeeb qhov muaj mob ntawm kev mob raum tsis ua haujlwm hauv ntshav qab zib nephroangiopathy.

Qhov txo qis hauv cov ntshav siab, hauv kev sib piv rau cov vasodilators ncaj qha (hydralazine, minoxidil, thiab lwm yam) tsis nrog los ntawm reflex tachycardia thiab ua rau txo qis ntawm myocardial oxygen xav tau. Thaum lub plawv tsis ua haujlwm hauv ib qho tsim nyog tsis cuam tshuam tus nqi ntawm cov ntshav siab.

Qhov siab tshaj plaws nyob rau hauv cov ntshav siab tom qab kev tswj hwm ntawm qhov ncauj pom tom qab 60-90 feeb. Lub sijhawm ntev ntawm qhov kev tiv thaiv hypotensive yog koob tshuaj-thiab nce mus txog qhov muaj txiaj ntsig zoo hauv ob peb lub lis piam.

Sab sij huam

Los ntawm CCC: tachycardia, txo qis ntshav siab, mob ntshav orthostatic hypotension.

Los ntawm cov hlab ntsha hauv lub cev: kiv taub hau, mob taub hau, zoo nkaus li nkees, ua pa nyuaj, txhaws caj dab.

Los ntawm cov kab mob urinary: proteinuria, lub raum khiav tsis zoo (nce concentration ntawm urea thiab creatinine hauv cov ntshav).

Los ntawm sab ntawm cov dej-electrolyte metabolism: hyperkalemia, acidosis.

Los ntawm cov ntshav hemopoietic plab hnyuv siab raum: neutropenia, anemia, thrombocytopenia, agranulocytosis.

Ua xua: angioedema, ntws los ntshav rau ntawm daim tawv nqaij ntawm lub ntsej muag, kub taub hau, tawm pob ntawm daim tawv nqaij (maculopapular, tsis tshua muaj hlwv los yog mob heev), khaus, photosensitivity, bronchospasm, ntshiab ntshav mob, lymphadenopathy, nyob rau hauv cov xwm txheej tsis tshua muaj, qhov tshwm sim ntawm cov tshuaj tiv thaiv kab mob hauv cov ntshav.

Los ntawm lub plab zom mov: saj tsis txaus, tsis qab los noj mov, mob plab, ua kom tsis haum plab, xeev siab, mob plab, cem quav lossis zawv plab, nce kev ua haujlwm ntawm hepatic transaminases, hyperbilirubinemia, cov tsos mob ntawm hepatocellular puas (mob siab) thiab cholestasis (hauv qee kis), pancreatitis (nyob rau hauv tus neeg mob cais).

Lwm yam: "qhuav" hnoos, dhau mus tom qab tsum tsis siv tshuaj, asthenia, o ntawm ceg. Cov tsos mob: tus cim txo qis hauv cov ntshav siab, nce mus txog vau, myocardial infarction, mob cerebrovascular mob hnyav, muaj teeb meem thromboembolic.

Kev Kho Mob: muab tus neeg mob nrog ceg qis qis dua, ntsuas ntsuas los kho kom ntshav siab (nce hauv BCC, suav nrog iv infusion ntawm 0.9% NaCl tov), ​​kho cov tsos mob. Hauv cov neeg laus, mob hemodialysis ua tau, peritoneal lim ntshav yog qhov ua tsis tau zoo.

Cov lus qhia tshwj xeeb

Ua ntej pib, zoo li tsis tu ncua thaum kho nrog captopril, lub raum kev ua haujlwm yuav tsum raug saib xyuas. Hauv cov neeg mob uas muaj CHF, lawv raug siv los ntawm kev saib xyuas mob nkeeg zoo.

Tawm tsam keeb kwm yav dhau los ntawm kev siv lub sijhawm ntev ntawm captopril hauv kwv yees li 20% ntawm cov neeg mob, muaj qhov nce ntxiv ntawm kev saib xyuas ntawm urea thiab creatinine hauv ntshav dej ntau dua 20% piv rau cov cai lossis pib tus nqi. Tsawg dua 5% ntawm cov neeg mob, tshwj xeeb tshaj yog cov neeg muaj kev puas hlwb loj, yuav tsum tau txais kev kho mob vim tias muaj kev tsim tawm ntawm creatinine.

Hauv cov neeg mob uas muaj kev mob ntshav nrog mob captopril, mob ntshav qab los ntshav ntau heev yog pom hauv qee yam tsis tshua muaj, qhov ntxim nyiam ntawm kev txhim kho tus mob no nce ntxiv nrog qhov tsis muaj peev xwm (poob) ntawm cov kua dej thiab ntsev (piv txwv, tom qab kev kho mob nrog diuretics), hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev los yog mob lim ntshav.

Tseem ua tau kom ntshav siab me dua tuaj yeem txo qis nrog kev tshem tawm ua ntej (4-7 hnub) ntawm ib qho tshuaj diuretic lossis nce ntxiv ntawm NaCl noj (kwv yees li 1 lub lis piam ua ntej pib tswj), lossis los ntawm kev sau ntawv noj captopril thaum pib kho mob me me (6.25-12.5 mg / hnub).

Thaum kho los ntawm kev kho mob sab nraud, ceeb toom rau tus neeg mob txog qhov tshwm sim uas muaj tsos mob ntawm kev kis tus kab mob, yuav tsum tau kuaj mob ntxiv, soj ntsuam mob thiab kuaj hauv tsev kho mob. Hauv thawj 3 lub hlis ntawm kev kho, tus naj npawb ntawm cov ntshav leukocytes tau kuaj xyuas txhua lub hlis (txuas ntxiv - ib zaug txhua 3 lub hlis), hauv cov neeg mob uas muaj cov kabmob autoimmune hauv thawj 3 lub hlis - txhua 2 asthiv, tom qab ntawd - txhua 2 hlis. Yog tias cov lej ntawm leukocytes tsawg dua 4 txhiab / μl, ib qho kev kuaj ntshav rau txhua tus tau qhia, qis dua 1 txhiab / μl, cov tshuaj txiav tawm. Yog tias thawj cov tsos mob ntawm tus kab mob theem nrab tshwm sim tawm tsam keeb kwm ntawm myeloid hypoplasia, kev kuaj ntshav ntxaws ntxaws yuav tsum tau ua tam sim ntawd.

Nws yog ib qho tsim nyog kom tshem tawm qhov tsis ua qhov kev ywj pheej ntawm cov tshuaj thiab ib qho kev ywj pheej ntxiv rau qhov kev siv dag zog ntawm kev siv dag zog.

Qee qhov xwm txheej, tawm tsam keeb kwm ntawm kev siv ACE inhibitors, suav nrog captopril, muaj kev nce ntxiv nyob rau hauv qhov kev coj siab ntawm K + hauv ntshiab. Txoj kev pheej hmoo ntawm kev tsim hyperkalemia nrog kev siv ACE inhibitors tau nce rau hauv cov neeg mob raum tsis ua haujlwm thiab mob ntshav qab zib mellitus, nrog rau cov uas noj cov tshuaj potassium-sparing diuretics, K + tshuaj lossis lwm yam tshuaj uas ua rau muaj kev nce ntxiv ntawm K + hauv cov ntshav (piv txwv li, heparin). Kev siv cov pa tshuaj hu ua potassium-sparing diuretics thiab K + kev npaj txhij yuav tsum zam.

Thaum coj tus kab mob hemodialysis hauv cov neeg mob uas tau txais captopril, kev siv cov qib siab permeability dialysis (e.g. AN69) yuav tsum zam, vim tias qee qhov kev pheej hmoo ntawm kev tsim cov tshuaj tiv thaiv kev tsis haum tshuaj tau nce ntxiv.

Nyob rau hauv txoj kev loj hlob ntawm kev mob siab mob hlwb, cov tshuaj tau raug muab tso tseg thiab meej kev saib xyuas kev kho mob thiab cov tsos mob zoo nkauj yog nqa tawm.

Thaum noj cov tshuaj captopril, qhov tseeb tshwm sim tsis zoo tuaj yeem pom thaum tshawb xyuas zis rau acetone.

Cov neeg mob noj cov zaub mov uas tsis muaj ntsev los yog ntsev ntau muaj qhov kev pheej hmoo ntawm kev txo cov ntshav siab ntau dua thiab kev txhim kho hyperkalemia.

Thaum lub sijhawm kho mob, yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm yam kev phom sij uas yuav tsum muaj kev mloog zoo dua thiab ceev ntawm lub hlwb kev xav (kev kiv taub hau yog ua tau, tshwj xeeb yog tom qab noj thawj koob).

Kev sib txuam

Tsub kom cov concentration ntawm digoxin hauv plasma ntau npaum li 15-20%.

Cimetidine, ua rau qeeb hauv cov metabolism hauv lub siab, ua rau kev nthuav dav ntawm captopril hauv cov ntshav.

Cov nyhuv tshuaj tiv thaiv yog tsis muaj zog los ntawm NSAIDs (Na + khaws cia thiab txo Pg synthesis), tshwj xeeb tshaj yog tiv thaiv keeb kwm ntawm qis renin concentration, thiab estrogens (Na + qeeb).

Kev sib xyaw nrog thiazide diuretics, vasodilators (minoxidil), verapamil, beta-blockers, tricyclic antidepressants, ethanol txhim kho cov nyhuv hypotensive.

Kev siv sib xyaw nrog cov tshuaj potassium-sparing diuretics, K + npaj, cyclosporine, tsis muaj Na + mis nyuj (tej zaum yuav muaj K + txog 60 mmol / l), cov tshuaj ntxiv poov tshuaj, ntsev hloov pauv (muaj ntau ntawm K +) ntau qhov kev pheej hmoo ntawm hyperkalemia.

Kev ua haujlwm qeeb ua rau qhov tsis txaus ntawm Li + tshuaj.

Clonidine txo qhov hnyav ntawm cov nyhuv hypotensive.

Nrog rau kev teem caij ntawm captopril thaum noj allopurinol lossis procainamide, qhov kev pheej hmoo ntawm kev tsim Stevens-Johnson syndrome thiab cov tshuaj tiv thaiv kab mob nce ntxiv.

Kev siv cov tshuaj captopril hauv cov neeg mob uas tau txais cov tshuaj tiv thaiv kab mob (piv txwv li azathioprine lossis cyclophosphamide) nce qhov kev pheej hmoo ntawm kev tsim hematologic tsis zoo.

Ceev faj rau kev siv

Txoj kev kho yog ua tiav los ntawm kev saib xyuas kev noj qab haus huv tas li. Thaum lub sij hawm kho, kev saib xyuas cov ntshav siab, cov qauv ntawm cov ntshav peripheral, qib protein, plasma potassium, urea nitrogen, creatinine, lub raum kev ua haujlwm, lub cev nyhav, thiab kev noj zaub mov yog qhov tsim nyog. Nrog rau kev txhim kho hyponatremia, lub cev qhuav dej, kev kho ntawm cov tshuaj ntau dua yog tsim nyog. Ceev faj yog yuav tsum tau ua thaum ua kev cuam tshuam kev phais mob (suav nrog kev kho hniav), tshwj xeeb tshaj yog thaum siv cov tshuaj loog dav dav uas muaj cov nyhuv hypotensive. Nws raug nquahu kom tsis suav txoj kev haus cawv thaum lub sijhawm kho. Siv nrog ceev faj thaum ua haujlwm rau cov tsav tsheb thiab cov neeg uas muaj kev cuam tshuam los ntawm kev saib xyuas ntau ntxiv. Yog tias cov koob tshuaj hla, qhov txuas ntxiv tsis yog ob npaug. Thaum ua qhov kev ntsuam xyuas rau cov kab mob acetonuria, muaj txiaj ntsig tshwm sim yog qhov ua tau.

Sab sij huam

Los ntawm ib sab ntawm lub paj hlwb thiab lub cev hauv nruab nrog: nkees, kiv taub hau, mob taub hau, poob siab ntawm lub hauv nruab nrab lub paj hlwb, nkees nkees, tsis meej pem, kev nyuaj siab, ataxia, cramps, loog lossis tingling hauv qhov kawg, tsis pom kev tsis pom kev thiab / lossis tsis hnov ​​tsw. Los ntawm cov hlab plawv system thiab ntshav (hematopoiesis, hemostasis): hypotension, suav nrog orthostatic, angina pectoris, myocardial infarction, mob plawv dhia tsis ua hauj lwm (atrial tachy lossis bradycardia, atrial fibrillation), palpitations, mob hlwb cerebrovascular, mob peripheral edema, lymphadenopathy, ntshav liab, mob hauv siab, pulmonary embolism, pulmonary embolism, pulmonary embolism nrog lub raum ua haujlwm tsis zoo, tawm tsam keeb kwm yav dhau los ntawm collagenoses), thrombocytopenia, eosinophilia. Los ntawm cov kab mob ua pa: bronchospasm, ua pa luv, interstitial pneumonitis, mob ntsws, mob ntsws hnoos qeev. Los ntawm lub plab zom mov: tsis nco qab, saj tsis meej, stomatitis, mob tawm tsam ntawm lub plab mos ntawm lub qhov ncauj thiab lub plab, xerostomia, glossitis, teeb meem nyuaj rau nqos, xeev siab, ntuav, dyspepsia, flatulence, mob plab, cem quav los yog raws plab, pancreatitis, mob siab rau (cholestasis , mob cholestatic mob siab, hepatocellular necrosis). Los ntawm cov kab mob genitourinary: ua rau lub raum tsis ua haujlwm, oliguria, proteinuria, impotence. Los ntawm daim tawv nqaij: liab ntawm lub ntsej muag, tawm pob, khaus khaus, exfoliative dermatitis, tshuaj lom epidermal necrolysis, pemphigus, herpes zoster, alopecia, photodermatitis. Kev tsis haum tshuaj: Stevens-Johnson mob, urticaria, Quincke's edema, ceeb toom tshuaj tiv thaiv, thiab lwm yam: ua npaws, ua daus no, mob sepsis, arthralgia, hyperkalemia, gynecomastia, mob ntshav siab, ntshav nce ntshav siab ntawm daim siab enzymes, urea nitrogen, acidosis, zoo cov tshuaj tiv thaiv thaum ntsuas cov tshuaj rau cov tshuaj tiv thaiv nuclear.

Tsuas tshuaj thiab tswj hwm

Sab hauv, 1 teev ua ntej noj mov. Kev noj tshuaj yog muab teeb ib leeg zuj zus.

Nrog kev mob ntshav liab - nyob rau hauv thawj koob tshuaj 25 mg 2 zaug hauv ib hnub. Yog tias tsim nyog, qhov koob tshuaj yog maj mam (nrog ntu nruab nrab ntawm 2-4 lub lis piam) nce ntxiv kom txog thaum cov txiaj ntsig zoo ua tiav. Nrog rau cov ntshav me me los sis mob ntawm cov ntshav, cov txij nkawm ib txwm yog 25 mg 2 zaug hauv ib hnub. Qhov tshuaj ntau ntau yog 50 mg 2 zaug ib hnub. Hauv kev mob ntshav siab tshaj plaws, qhov ntau tshaj yog 50 mg 3 zaug ib hnub. Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 150 mg.

Hauv kev mob plawv mus ntev, Angiopril yog tus kws kho mob uas siv cov tshuaj diuretics tsis muaj kev cuam tshuam txaus. Qhov nruab nrab ntawm kev saib xyuas txij nkawm yog 25 mg 2-3 zaug ib hnub. Yav tom ntej, yog tias tsim nyog, nce qhov koob tshuaj (nrog lub sijhawm tsawg kawg 2 lub lis piam). Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 150 mg.

Rau cov neeg mob uas muaj quag ua lub ntsej muag tsis hnov ​​mob lub raum (Cl creatinine tsawg kawg 30 ml / min), Angiopril tuaj yeem raug txhaj tshuaj ntawm 75-100 mg / hnub. Nrog kev tshaj tawm hais txog qhov tsis ua haujlwm lub raum (Cl creatinine ® -25)

Khaws tsis ncav cuag ntawm cov menyuam yaus.

Lub Npe Tsis Yog Neeg Tsis Muaj Npe

Lub npe thoob ntiaj teb nonproprietary rau cov khoom yog Captopril.

Rau lawv cov kev kho mob ntawm cov hlab ntshav, txoj kev kho nyuaj yog qhov yuav tsum tau, uas suav nrog kev noj tshuaj, uas suav nrog angiopril.

Cov tshuaj muaj ATX code hauv qab no: C09AA01.

Tso cov ntaub ntawv thiab cov nyob ua ke

Kev tso tawm ntawm cov tshuaj yog nqa tawm hauv daim ntawv ntawm cov ntsiav tshuaj muab tso rau hauv ib daim hlab ntawm 10 pcs thiab 4 pcs. Ib pob ntawv cardboard tuaj yeem suav 1, 3, 10 nti ntawm 10 ntsiav tshuaj txhua lossis 1 kab ntawv nrog 4 ntsiav tshuaj. Tus nquag ua hauj lwm yog captopril - 25 mg. Tsis tas li ntawd, stearic acid, lactose, pob kws hmoov txhuv nplej siab, colloidal silicon dioxide thiab microcrystalline cellulose siv.

Cov Tshuaj Pharmacokinetics

Tom qab noj cov ntsiav tshuaj, nws tau nrawm rau hauv lub plab zom mov vim tias kev siv bioavailability ntawm 60-70%. Kev ua kom qeeb yog pom nrog kev siv captopril tib lub sijhawm nrog zaub mov. Ib nrab-lub neej ntawm cov tshuaj yuav siv 2-3 teev. Ib nrab ntawm cov tshuaj ua kom nquag plias yog tawm hauv cov zis tsis hloov pauv.

Nrog ntshav qab zib

Yog tias tus neeg mob muaj ntshav qab zib nephropathy, tom qab ntawd cov tshuaj raug coj ntawm 75-150 mg ib hnub twg. Cov koob tshuaj yuav tau pauv los ntawm koj tus neeg saib xyuas kev noj qab haus huv.

Yog tias tus neeg mob muaj ntshav qab zib nephropathy, tom qab ntawd cov tshuaj raug coj ntawm 75-150 mg ib hnub twg.

Daim ntawv thov rau lub siab ua haujlwm tsis zoo

Ua tib zoo thiab nyob rau hauv kev saib xyuas mob nkeeg, lawv siv cov tshuaj rau teeb meem mob siab.

Cawv tau zoo

Thaum kho lub sijhawm, nws yog txwv tsis pub haus dej cawv. Lawv cov kev sib cuam tshuam nrog kev txuam nrog tuaj yeem ua rau kub siab tsis tseg.

Thaum kho lub sijhawm, nws yog txwv tsis pub haus dej cawv.

Yog tias tsim nyog, cov tshuaj yog hloov los ntawm ib qho tshuaj tiv thaiv. Ntawm lawv yog cov hauv qab no:

Cov kev hloov pauv hauv txoj kev kho yuav tsum yog tus kws kho mob uas xaiv cov tshuaj tau noj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob lub cev thiab qhov mob ntawm cov kab mob pathology.