Txheej txheem cej luam ntawm cov tshuaj statin kom txo cov roj (cholesterol)
Qhov tseeb tshaj tawm tam sim no tau lees paub tias yog cov tshuaj siv tau zoo tshaj plaws thiab muaj kev nyab xeeb hauv kev sib tua tawm tsam cov teeb meem ntawm atherosclerosis. Tshuaj pab txo qis cov roj cholesterol, zoo li lwm yam khoom ntawm cov rog metabolism. Kev noj cov tshuaj statins ncua kev pheej hmoo ntawm kev tsim muaj cov hlab plawv mob hnyav - lub plawv nres, mob hlab ntsha tawg.
Kab mob plawv yog thawj qhov chaw ntawm cov ua rau kev tuag. Raws li Ministry of Health, xyoo 2017, 47.8% ntawm cov neeg pej xeem Lavxias tuag ntawm kev mob plawv. LEEJ TWG kwv yees tias daim duab no yuav nce ntxiv vim tias muaj hnub nyoog qeeb qeeb, nrog rau kev ua neej pauv.
Statins: nws yog dab tsi, leej twg yog tus xa
Statins yog cov tshuaj uas thaiv cov biosynthesis ntawm roj nyob hauv lub siab, hloov HMG-CoA reductase enzyme. Yog li, lawv lub npe tseem ceeb yog HMG-CoA reductase inhibitors. Ib qho ntxiv, statins txo qhov tseem ceeb ntawm cov "lipoproteins" tsawg-ceev lipoproteins (LDL), nce qib ntawm "zoo" high-density lipoproteins (HDL).
Ua kom lub siab ntawm cov roj (cholesterol), LDL, HDL pab tiv thaiv cov kev hloov pauv ntawm atherosclerosis, nws cov teeb meem: mob plawv, mob ntshav nce hlwb, necrosis ntawm cov qis qis. Ua ke nrog cov mob thrombosis thiab mob ntshav siab, tus kab mob no tau lees paub tias muaj kev tuag ntau tshaj plaws ntawm txhua txoj hlab plawv.
Hauv Tebchaws Europe, Tebchaws Asmeskas, kev coj ua ntawm kev tsim cov tshuaj statins yog ib yam muaj ntau. 95% ntawm Asmeskas, 55% ntawm cov neeg mob European uas tau muab tshuaj rau noj, coj lawv. Nyob rau hauv Russia, daim duab no tsuas yog 12%. Lwm qhov kev tshawb nrhiav thoob ntiaj teb, VALIANT, pom tias peb cov kws kho mob tau sau cov statins 100 zaus tsawg dua li lawv cov phooj ywg txawv teb chaws.
Kho cov tshuaj statins tso cai rau koj:
- txo txoj kev pheej hmoo ntawm lub plawv nres, mob hlab ntsha tawg,
- txo cov naj npawb ntawm cov neeg mob uas muaj lub siab tsis txaus siab yuav tsum mus pw hauv tsev kho mob,
- txo cov haujlwm kom rov ua kom ntshav khiav,
- tiv thaiv angina tawm tsam.
Txawm hais tias qhov kev kho mob hnyav muaj peev xwm loj, cov ntsiav tshuaj statin tau coj los ntsuas pom tseeb, thiab tsis yog rau kev nce ntxiv hauv cov cholesterol. Lawv tsis muaj mob, muaj cov kev mob tshwm sim loj heev. Statins pom zoo rau tib neeg:
- cov muaj txoj sia nyob ntawm kev mob plawv nres, mob stroke, microstroke,
- npaj rau kev phais ntawm cov hlab ntsha,
- nrog LDL ntau ntau dhau 190 mg / dL (4.9 mmol / L),
- kev mob ntshav qab zib thiab muaj qhov tsis txaus siab LDL ntawm 70-189 mg / dl (1.8-4.9 mmol / l),
- cov menyuam yaus tshaj 10 xyoo rov hauv uas muaj kev pheej hmoo los ntawm kev mob plawv nres thaum ntxov.
Atorvastatin
Cov khoom lag luam muag khoom zoo tshaj plaws hauv lub ntiaj teb. Hauv lub hwj chim, nws yog ua ntej ntawm cov tshuaj ua ntej (simvastatin, pravastatin, lovastatin). Nws siv hauv cov neeg mob feem ntau tso cai rau koj kom ua tiav cov kev txo qis hauv cov roj cholesterol mus rau qib uas tau pom zoo. Tib lub sijhawm, tus nqi ntawm cov ntsiav tshuaj tau ntau dua piv rau rosuvastatin, thiab kev zam rau ntau tus neeg mob yog qhov zoo dua.
Rosuvastatin
Cov tshuaj no suav hais tias yog qhov haib tshaj plaws ntawm cov uas twb muaj lawm. Rosuvastatin tau sau tseg hauv feem ntau tshaj plaws, thaum lub sijhawm teem sijhawm ntawm lwm cov tshuaj tsis pub kom ua tiav qhov txo qis hauv cov roj cholesterol, LDL. Niaj hnub no tsis muaj kev pom zoo ntawm kev tsim nyog ntawm nws qhov kev siv rau hauv cov neeg mob uas mob hypercholesterolemia me ntsis, muaj kev pheej hmoo me ntawm kev tsim mob plawv. Cov tshuaj tau tawm tsis ntev los no, nws txoj haujlwm tau tshawb pom muaj kev phem dua li atorvastatin. Yog li, qee cov lus nug, tshwj xeeb yog tias lawv cuam tshuam nrog lub sijhawm ntev, tsis muaj lus teb meej.
Pitavastatin
Qhov tsis tshua muaj koob pheej ntawm cov tshuaj 4 tiam, uas yog tsim los ntawm lub tuam txhab Spanish Recordati Kev Lag Luam Chemist Pharmaseutics nyob hauv kev lag luam npe Livazo. Piv rau rosuvastatin nrov, nws tau kawm ntau yam kev tsis zoo. Yog li, cov kws kho mob sau tseg cov tshuaj pitavastatin kom txo qis cov roj hauv lub cev. Nws feem ntau yog kho rau cov neeg mob yog qhov hloov pauv rau rosuvastatin thaum tsis nkag rau. Tus nqi ntawm Livazo yog 540-1205 rubles.
Cov kev cai ntawm lub xeem tiam: cov npe ntawm cov tshuaj ntawm 3, 4 tiam yog qhia hauv lub rooj.
Lub npe tshuaj | Kev xaiv koob tshuaj, mg | Tus nqi, tshiav. |
---|---|---|
Nquag khoom xyaw - atorvastatin | ||
Atorvastatin | 10, 20, 40, 80 | 70-633 |
Atorvastatin Alkaloid | 86-215 | |
Atorvastatin MS | 10, 20, 40 | 78-153 |
Atorvastatin SZ | 10, 20, 40, 80 | 54-497 |
Atorvastatin OBL | 10, 20, 40, 80 | 171-350 |
Atorvastatin LEXVM | 10, 20 | 85-210 |
Atorvastatin Teva | 10, 20, 40, 80 | 74-690 |
Atoris | 10, 20, 30, 40, 60, 80 | 175-1248 |
Vazator | 10, 20 | 291-388 |
Liprimar | 10, 20, 40, 80 | 590-1580 |
Novostat | 10, 20, 40, 80 | 100-497 |
Thorvacard | 10, 20, 40 | 238-1773 |
Keebkwm | 10, 20, 40, 80 | 203-440 |
Tulip | 10, 20, 40 | 111-1180 |
Nquag khoom xyaw - rosuvastatin | ||
Akorta | 10, 20 | 350-1279 |
Neeg Coob | 5, 10, 20, 40 | 1458-9398 |
Ua Ntshav Qab Zib | 5, 10, 20 | 355-460 |
Mertenyl | 5, 10, 20, 40 | 338-2200 |
Cuam Tshuam | 5, 10, 20, 40 | 327-1026 |
Ro statin | 5, 10, 20, 40 | 449-699 |
Hlua | 5, 10, 20, 40 | 202-2839 |
Rosistark | 10, 20, 40 | 225-1850 |
Rosuvastatin-SZ | 5, 10, 20, 40 | 158-1260 |
Rosuvastatin Vial | 10, 20 | 331-520 |
Kwv Txhiaj Ntsuag | 5, 10, 15, 20, 30 ,40 | 353-2098 |
Rosucard | 10, 20, 40 | 374-3800 |
Rosulip | 5, 10, 20, 40 | 240-1736 |
Suvardio | 5, 10, 20, 40 | 220-912 |
Tevastor | 5, 10, 20, 40 | 303-2393 |
Hom statins tshiab twg yog cov muaj qhov phiv tsawg tshaj? Cov kev nyab xeeb tshaj plaws yog cov thawj cov tshuaj Statins Liprimar (atorvastatin), Crestor (rosuvastatin). Lawv tus nqi yog txawv ntau los ntawm analogues, tab sis nws muaj siab tag nrho. Yog tias tus neeg mob cov nyiaj tau tsawg dua, nws tau raug hloov chaw hloov chaw uas muaj lub koob npe zoo: Tulip, Torvakard, Atoris, Rosucard, Lipoprim. Tus kws kho mob tuaj yeem sau tshuaj rau lwm cov tshuaj raws li lawv tus kheej tau paub nrog cov tshuaj. Tsis txhob yuav qhov zoo pheej yig tshaj. Lawv cov hauj lwm zoo, kev nyab xeeb yog nyob hauv kev ua xyem xyav.
Qhov sib txawv ntawm cov tshuaj ntawm cov tshiab thiab qub cim
Muaj 4 tiam ntawm statins:
- thawj yog simvastatin, lovastatin, pravastatin,
- qhov thib ob yog fluvastatin,
- qhov thib peb yog atorvastatin,
- plaub yog rosuvastatin, pitavastatin.
Rosuvastatin 1.5-2 zaug zoo dua txo LDL dua li atorvastatin, 4 zaug dua li simvastatin, 8 zaug dua li pravastatin lossis lovastatin. Qhov kev cia siab ntawm lipoproteins "phom sij" yog suav tias yog qhov ntsuas tseem ceeb uas cuam tshuam rau kev ua kom tsawg kawg ntawm kev pheej hmoo ntawm cov teeb meem plawv. Nws yog siv txhawm rau twv kom zoo ntawm cov tshuaj.
Kev siv cov metabolism ntawm statins ntawm lub xeem tiam zoo ib yam li cov tshuaj ntawm 1-2 tiam, tab sis nrog cov kev mob tshwm sim me me. Qhov no tso cai rau koj kom muab tshuaj rau lawv ib txhij nrog qee cov tshuaj uas tsis sib xws nrog simva-, nuv ntses, pravastatin. Qhov txiaj ntsig zoo no nthuav dav lub voj voog ntawm cov neeg mob muaj peev xwm.
Qhov sib txawv tseem ceeb ntawm cov statins ntawm cov tub ntxhais hluas tam sim no yog lub peev xwm los txo qis ntawm C-reactive protein (CRP factor). Cov kev tshawb fawb tshiab yog yuam cov kws kho mob kom paub txog tias qhov khoom no tuaj yeem ua si tsis muaj lub luag haujlwm hauv cov kev ua mob ntawm atherosclerosis dua li cov roj (cholesterol). Kev kho kom zoo ntawm nws qib tso cai rau koj ntau txoj kev los tiv thaiv tus kab mob, nrog rau kev tiv thaiv kev txhim kho ntawm lub neej muaj teeb meem. Cov cuab yeej no tau pom tseeb tsuas yog nyob hauv rosuvastatin, nrog rau nws cov analogues.
Lwm yam tshuaj sib txuam
Thib peb thiab plaub tiam statins tau zoo dua nrog lwm cov tshuaj. Atorvastatin tsis tuaj yeem raug sau cia nrog:
- gemfibrozil,
- kev sib xyaw ntawm tipranavir nrog ritonavir,
- telaprevir
- cyclosporine.
Kev kho cov tshuaj ntawm cov ntsiav tshuaj yog tsim nyog thaum noj nrog cov tshuaj hauv qab no:
- boceprivir,
- verapamil
- digoxin
- diltiazem
- itraconazole,
- clarithromycin,
- colchicine
- lopinavir nrog ritonavir,
- nelfinavir
- niacin
- omeprazole
- ezetimibe.
Rosuvastatin ntsiav tshuaj sib txawv los ntawm lwm cov statins hauv lawv qhov kev cuam tshuam tsawg kawg nkaus nrog cytochrome P450 enzymes. Nws tuaj yeem ua tau, tab sis tsis xav tau, raug coj los ua ntxiv rau chav kawm ntawm kev kho mob nrog cov tshuaj uas lwm HMG-CoA reductase inhibitors yuav tsis sib xws. Kev npaj Rosuvastatin tsis raug siv rau cov neeg mob uas siv cov tshuaj fibrates, cyclosporine.
Cov txiaj ntsig thiab kev phom sij ntawm statins
Cov tshuaj ntawm cov tshuaj rau cov cim tshiab ntawm cov roj (cholesterol) siab yog qhov tseeb yog tias muaj pov thawj. Raws li kev tshawb fawb, kev siv cov rosuvastatin tuaj yeem txo los ntawm:
- 20% tag nrho cov neeg tuag,
- 44% kev ploj tuag los ntawm kev mob siab ntawm atherosclerosis,
- 50% txoj hmoo ntawm kev tsim mob stroke, lub plawv nres.
Lwm cov statins tuaj yeem khav theeb ntau dua, tab sis tseem qhov txiaj ntsig zoo. Lawv lub hom phiaj tuaj yeem raug txo los ntawm:
- 20-42% mob hlwb tuag,
- 25-37% kev tshwm sim ntawm myocardial infarction,
- 28-31% kev pheej hmoo ntawm mob hlab ntsha tawg.
Hmoov tsis zoo, statins tsis muaj kev nyab xeeb kiag li. Ntsiav tshuaj muaj ntau yam muaj kev cuam tshuam loj heev, tus lej xov tooj sib kis. Lawv tsis kho rau cov neeg uas:
- muaj kab mob siab
- cov menyuam hluas (tshwj tsis yog - muaj tsawg tus kab mob, uas yog muaj tus mob hauv siab),
- cov poj niam cev xeeb tub, thiab cov poj niam uas npaj xeeb tub,
- mis txiag.
Feem ntau cov kev mob tshwm sim tsis muaj kev phom sij. Txog 12% ntawm cov neeg mob tau mob qa, 6.6% mob taub hau, 5.3% ntawm cov tsos mob zoo li mob khaub thuas, 5.1% mob nqaij. Cov neeg mob feem ntau qhia txog kev txhim kho hauv kev noj qab haus huv tag nrho thaum noj cov tshuaj tom qab ob peb hnub lossis ntau lub lis piam. Tab sis qee cov neeg txuas ntxiv ntsib kev tsis xis nyob thoob plaws hauv chav kawm.
Qhov kev tshaj tawm dhau los uas yuav ua rau kom tshem tawm kev phiv tshuaj yog tso tshuaj statins. Ua ntej yuav txiav txim siab tsis ua kev kho mob, kws kho mob pom zoo suav qhov nyhav thiab zoo. Tom qab tag nrho, statins txuas ntxiv tus neeg lub neej, thiab nws tsim nyog los tso nrog kev cuam tshuam me rau kev nyob zoo. Ntxiv mus, muaj lwm txoj hauv kev los txhim kho qhov mob dav dav:
- pom zoo kom so luv nyob hauv kev noj tshuaj. Saib qhov kev hloov pauv. Qee zaum mob leeg, qhov tsis muaj zog dav dav yog qhov muaj txiaj ntsig ntawm kev laus lossis lwm yam kab mob, thiab tsis yog kev mob tshwm sim ntawm cov tshuaj. Lawv txoj kev kho yuav ua rau kom tsis xis nyob,
- Hais kom koj tus kws kho mob hloov cov tshuaj lossis txo qhov tsuas tshuaj. Statins yog cov pab pawg muaj ntau yam tshuaj, uas tso cai rau txhua tus neeg mob xaiv cov tshuaj uas zoo rau nws,
- Sib tham txog kev sib xyaw ua ke ntawm statins thiab lwm cov tshuaj txo cov roj (cholesterol). Statins yog cov tshuaj zoo tshaj plaws rau kev ua kom cov roj (cholesterol) phem muaj ntau. Tab sis qee zaum, lawv cov tshuaj sib xyaw nrog lwm cov tshuaj tuaj yeem txo qhov koob tshuaj, ua kom qis ntawm LDL tsawg li tsawg.
- tawm dag zog kom zoo. Kev qoj ib ce tuaj yeem ua rau cov leeg mob ntawm qib cellular. Tawm tsam keeb kwm ntawm kev noj HMG-CoA reductase inhibitors, qhov no yog fraught nrog cov leeg mob hnyav. Tej zaum nws yuav tsim nyog los kho cov phiaj xwm qhia los ntawm kev txo me ntsis ntawm lub nra,
- noj coenzyme Qhov kev noj haus kev noj haus no pab tiv thaiv qee qhov kev mob tshwm sim hauv cov neeg tsawg.
Nws ntseeg tau tias inhibitors HMG-CoA reductase tuaj yeem ua rau mob ntshav qab zib. Qhov kev pom no tsuas yog ib nrab ntawm qhov tseeb. Kev tshawb nrhiav JUPITER loj dua, thaum lub sijhawm kev noj qab haus huv ntawm 17 802 tus neeg mob uas tau siv rosuvastatin tau tshawb xyuas. Hom 2 mob ntshav qab zib mellitus tau tsim hauv 270 cov neeg mob noj tshuaj, tiv thaiv 216 tus neeg ntawm pathology ntawm cov neeg uas tau siv cov placebo. Cov kws kho mob piav qhia txog qhov tshwm sim me ntsis ntawm qhov tshwm sim thawj zaug ntawm tib neeg hauv pab pawg kawm txog kev txhim kho ntshav qab zib.
Vim li cas thiaj li cov roj (cholesterol) nce ntxiv?
Cholesterol yog ib qho organic compound uas nyob hauv lub cev thiab koom nrog nws ua haujlwm. Nws yog ib qho tseem ceeb ntawm cov roj ntsha metabolism.
Qhov kev kub siab ntawm cov tshuaj yeeb dej caw yuav dhau qhov tsim tau cov qauv. Qhov no cuam tshuam tsis zoo rau kev noj qab haus huv thiab ua rau ntau yam kabmob. Cov no suav nrog kev mob plawv thiab mob nkees, angina pectoris, atherosclerosis.
20% ntawm cov roj cholesterol sab nraud los ntawm cov khoom noj, cov seem 80% yog tsim los ntawm lub cev. Txhaum ntawm kev ua txhaum ntawm kev nqus thiab tshem tawm ntawm yam khoom ntawd, nws cov ntsiab lus hloov.
Sab hauv thiab sab nraud ua rau tuaj yeem ua rau nce cov cholesterol:
- teeb meem ntawm metabolic
- muaj mob muaj keeb predisposition
- ntev li ntawm tau ntawm cov khoom noj uas muaj cov tsiaj rog,
- kev siv qee yam tshuaj
- ntshav siab
- kev nyuaj siab mob ntsws
- mob ntshav qab zib mellitus
- tsis muaj kev tawm dag zog
- hormonal tsis txaus los yog rov kho dua tshiab,
- rog thiab rog dhau hwv lawm
- hnub nyoog siab heev.
Cov qauv ntsuas rau kev ntsuas yog:
- kuaj mob atherosclerosis thiab nws cov kev tiv thaiv thaum nws muaj kev pheej hmoo,
- muaj lwm cov kab mob plawv pathologies,
- raum pathology
- Cov kab mob endocrine - hypothyroidism,
- mob ntshav qab zib
- pathology ntawm lub siab.
Yog tias muaj kev txawv txav hauv kev tshawb pom, tus kws kho mob tau sau tseg ntau txoj hauv kev los txo cov roj (cholesterol). Cov tshuaj Statin tuaj yeem raug tshuaj raws li cov duab saib mob.
Dab tsi yog statins?
Qhov no yog pab pawg lipid-txo cov tshuaj tsim los txo cov roj (cholesterol) phem. Lawv txhaws cov kev ua haujlwm ntawm lub siab enzyme, uas koom nrog hauv kev tsim cov tshuaj yeeb dej caw.
Statins pom tau tias yog tshuaj zoo nyob rau hauv kev tiv thaiv ntawm tus thawj thiab rov ua mob plawv thiab mob nkees. Ib pawg ntawm cov tshuaj normalizes lub xeev ntawm cov hlab ntsha thiab tiv thaiv qhov tsim ntawm cov quav ntawm lawv.
Nrog kev noj tshuaj tsis tu ncua, cov neeg mob tswj tau txo qis roj kom txog 40%. Raws li kev txheeb cais, lawv txo kev tuag los ntawm kab mob plawv los ntawm yuav luag 2 zaug.
Cov tshuaj muaj cov roj uas ua rau cov roj-ua kom qis, txo cov synthesis ntawm lipoproteins los ntawm lub siab, ua kom cov khoom hauv cov ntshav, txo nws cov viscosity, nce qhov elasticity ntawm cov hlab ntsha, so thiab nthuav lawv, thiab tiv thaiv kev tsim cov plaques ntawm cov phab ntsa.
Yuav ntev npaum li cas? Cov tshuaj ua yeeb yam tsuas yog thaum txais tos, tom qab nws txiav, qhov ntsuas tuaj yeem rov qab mus rau cov nuj nqis yav dhau los. Kev siv mus tas li tsis suav nrog.
Kev ntsuas rau siv
Kev taw qhia rau kev siv statins los txo cov roj (cholesterol):
- hypercholesterolemia,
- atherosclerosis loj thiab qhov txaus ntshai ntawm nws txoj kev loj hlob,
- kev tiv thaiv tus mob stroke, lub plawv nres,
- kev saib xyuas kev saib xyuas tom qab mob hlab ntsha tawg, plawv nres,
- muaj hnub nyoog dhau los (raws li kev tshawb xyuas)
- angina pectoris
- Ischemic mob plawv,
- kev pheej hmoo ntawm kev txhaws ntawm cov hlab ntsha,
- homozygous muaj keeb kwm (tsev neeg) hypercholesterolemia,
- kev phais mob mus rau ntawm lub plawv thiab cov hlab ntshav.
Ntawm cov contraindications rau siv cov statins:
- raum tsis ua hauj lwm
- intolerance mus rau Cheebtsam
- cev xeeb tub
- kev pub niam mis
- kev siv tshuaj tiv thaiv qhov tsis haum
- hnub nyoog txog 18 xyoo.
Sau cov tshuaj statin
Cov tshuaj Statin yog sawv cev los ntawm 4 tiam.
Hauv txhua ntawm lawv muaj cov tshuaj nquag uas tau muab cais los ntawm lub sijhawm ntawm kev siv:
- Thawj tiam - Lovastatin, Simvastatin, Pravastatin. Lub hauv paus yog ntuj. Cov kev ua ntawm kev txo cov roj (cholesterol) yog 25%. Lawv siv tau tsawg dua ntawm kev txo qis thiab feem ntau qhia cov kev mob tshwm sim. Cov tiam yog sawv cev los ntawm cov tshuaj hauv qab no: Vasilip - 150 r, Zokor - 37 r, Lovastatin - 195 r, Lipostat - 540 r.
- Qhov thib ob tiam yog fluvastatin. Lub hauv paus yog khoom hluav taws xob ib nrab. Kev ntsuas kev nqis tes ua poob - 30%. ntev dua cov kev txiav txim thiab degree ntawm cawv on ntsuas tshaj predecessors. Lub cim thib 2 lub npe tshuaj: Leskol thiab Leskol Forte. Lawv tus nqi yog li 865 p.
- Qhov thib peb tiam yog Atorvastatin. Lub hauv paus yog hluavtaws. Cov kev ua haujlwm ntawm kev txo qhov tsis haum ntawm cov tshuaj yog nce mus txog 45%. Txo cov theem ntawm LDL, TG, nce HDL. Cov pab pawg muab tshuaj suav nrog: Atokor - 130 rubles, Atorvasterol - 280 p, Atoris - 330 p, Limistin - 233 p, Liprimar - 927 p, Torvakard - 250 p, Tulip - 740 p, Atorvastatin - 127 p.
- Plaub tiam yog Rosuvastatin, Pitavastatin. Lub hauv paus yog hluavtaws. Cov kev ua ntawm kev txo cov roj (cholesterol) yog kwv yees li 55%.Ib tug ntau tiam ntxiv, zoo tib yam nyob rau hauv kev txiav txim rau peb. Ua rau pom kev ua kom zoo ntawm kev siv tshuaj tsawg dua. Nrog rau lwm cov tshuaj plawv plawv. Muaj kev nyab xeeb thiab ua haujlwm zoo dua li cov tiam dhau los. Lub koob thib 4 pawg ntawm cov tshuaj suav nrog: Rosulip - 280 r, Rovamed - 180 r. Tevastor - 770 p, Rosusta - 343 p, Rosart - 250 p, Mertenil - 250 p, Crestor - 425 p.
Ua rau lub cev
Cov tshuaj Statin pab cov neeg mob plawv. Lawv txo tus mob hauv cov hlab ntsha, roj cholesterol, txo kev pheej hmoo ntawm lub plawv nres thiab ntshav npleem. Cov tshuaj noj kuj ua rau ntau cov kev mob tshwm sim los ntawm mob sib khuav mus rau mob hnyav.
Txij li cov ntsiav tshuaj noj mus ntev, lub siab yog qhov muaj kev pheej hmoo. Hauv cov txheej txheem ntawm kev kho mob, ob peb zaug hauv ib xyoos, cov ntshav biochemistry tau muab.
Kev phiv los sis cov tshuaj muaj xws li:
- kev tsis haum daim tawv nqaij,
- mob taub hau thiab kiv taub hau,
- nce qaug zog thiab qaug zog,
- lub plab zom zaws
- peripheral neuropathy,
- kab mob siab
- txo qis libido, impotence,
- mob plab
- peripheral edema,
- hnov lus tsis zoo, tsis nco txog qib sib txawv,
- thrombocytopenia
- leeg tsis muaj zog thiab cramps
- teeb meem mob siab
- mob hlwb
- thoob ntiaj teb kev mob ceev ceev - tsis tshua muaj,
- rhabdomyolysis muaj tsawg.
Yam tshuaj twg xaiv?
Statins yog cov pab pawg muaj zog. Lawv tsis yog npaj rau tus kheej tshuaj. Lawv tsuas yog kho los ntawm tus kws kho mob uas koom nrog, coj mus rau hauv tus account qhov mob hnyav thiab cov txiaj ntsig ntawm kev tshawb fawb. Nws yuav siv mus rau hauv txhua qhov kev pheej hmoo cuam tshuam nrog lub hnub nyoog, kab mob sib kis, noj lwm yam tshuaj.
Hauv rau lub hlis, kev tshawb xyuas biochemical xa txhua lub hlis los soj qab saib lub siab ua haujlwm li cas. Cov kev tshawb fawb txuas ntxiv tau nqa tawm 3-4 zaug hauv ib lub xyoo.
Cov tshuaj xaiv li cas? Tus kws kho mob xaiv cov tshuaj thiab cov ntawv sau yuav lub chav. Tom qab nws ua tiav, ntsuas muaj kev soj ntsuam. Thaum tsis muaj txiaj ntsig, nrog kev siv tshuaj tsis txaus, qhov pom ntawm cov kev mob tshwm sim, lwm cov tshuaj tau kho. Tau khaws cov tshuaj tsim nyog, cov txheej txheem raug hloov kho.
Cov kev mob tshwm sim, kev sib xyaw nrog lwm cov tshuaj, lub sijhawm tswj hwm tau siv rau hauv qhov kev txiav txim. Cov statins ntawm lub xeem tiam tau lees paub tias yog qhov zoo tshaj plaws. Lawv ua kom pom kev nce qib ntawm kev nyab xeeb thiab kev ua tau zoo.
Zoo tsis muaj kev cuam tshuam ntawm cov metabolism hauv qabzib, mus zoo nrog lwm cov tshuaj ntawm cov hlab plawv. Los ntawm kev txo qhov ntau npaum (nrog cov ua tiav), kev pheej hmoo ntawm kev tsim kev mob tshwm sim yog txo.
Zaj dab neeg video los ntawm Dr. Malysheva txog statins:
Tus neeg mob lub tswv yim
Kev kuaj xyuas tus neeg mob tau qhia tias muaj cov ntsiab lus zoo thiab qhov tsis zoo hauv kev kho statins. Ntau tus neeg sib cav hais tias nyob rau hauv kev sib ntaus tawm tsam cov roj (cholesterol) siab, cov tshuaj yeeb yam qhia pom tshwm sim. Coob tus ntawm cov kev mob tshwm sim kuj tau sau tseg.
Kev tshuaj xyuas ntawm cov kws kho mob txog statins tau sib xyaw. Qee qhov lees tias lawv muaj txiaj ntsig zoo thiab muaj txiaj ntsig, thaum lwm tus suav tias lawv yog qhov kev phem uas tsim nyog.
Lawv muab kuv Atoris txo cov roj (cholesterol). Tom qab noj cov tshuaj no, qhov ntsuas tau nqis ntawm 7.2 rau 4.3. Txhua yam zoo li yuav mus zoo, tom qab ntawd o tshwm sim sai, ntxiv rau qhov mob hauv pob qij txha thiab cov leeg pib. Tolerate ua tsis txaus ntseeg. Cov kev kho mob tau raug tshem tawm. Ob lub lis piam tom qab, txhua yam mus. Kuv yuav mus cuag kws kho mob sab laj, cia nws sau tshuaj rau ib co tshuaj ntxiv.
Olga Petrovna, 66 xyoo, Khabarovsk
Kuv txiv tau raug Crestor. Nws yog rau cov xeeb ntxwv kawg ntawm statins, feem ntau ib txwm muaj txhua yam. Ua ntej ntawd tau muaj Leskol, muaj ntau cov kev mob tshwm sim. Txiv Plig tau haus Krestor tau ob xyoos. Nws qhia tau tias muaj txiaj ntsig zoo, thiab lipid profile ntsib txhua tus qauv. Qee zaum muaj tsuas yog kem plab xwb. Tus kws kho mob uas tuaj koom hais tias qhov ua tau zoo dua li qhov xav tau. Txhawm rau txuag nyiaj, peb tsis xav hloov mus rau analogues pheej yig dua.
Oksana Petrova, 37 xyoo, St.
Tus niam tais tau noj cov tshuaj statins rau 5 xyoo tom qab mob hlab ntsha loj heev. Muaj ob peb zaug hloov cov tshuaj. Ib qho tsis txo qis roj, lwm tus tsis haum. Tom qab ua tib zoo xaiv, peb tau nres ntawm Akorta. Ntawm tag nrho cov tshuaj, nws muab ua qhov tsim nyog nrog cov kev mob tshwm sim tsawg dua. Niam pog niaj hnub tshuaj xyuas saib puas raug lub siab li. Qhov kev sim no tsis yog ib txwm muaj. Tab sis nyob rau hauv nws rooj plaub, tsis muaj kev xaiv tshwj xeeb.
Alevtina Agafonova, 42 xyoo, Smolensk
Tus kws kho mob tau hais kom Rosuvastatin rau kuv - nws tau hais tias tiam no yog qhov zoo tshaj plaws, muaj tsawg dua cov kev mob tshwm sim. Kuv nyeem cov lus qhia rau kev siv, thiab tseem ntshai me ntsis. Muaj ntau cov contraindications thiab cov kev mob tshwm sim dua li qhia thiab cov txiaj ntsig. Nws hloov tawm tias peb kho ib qho, thiab tuag ceg lwm tus. Kuv pib noj cov tshuaj, Kuv haus rau ib hlis, kom deb li deb tsis tas yuav tshaj.
Valentin Semenovich, hnub nyoog 60 xyoo, Ulyanovsk
Statins yog qhov tseem ceeb hauv atherosclerosis, mob plawv nres, thiab hlab ntshav tawg. Hmoov tsis zoo, nyob hauv qee kis tsis tuaj yeem ua yam tsis muaj lawv. Cov tshuaj kho tsis tuaj yeem daws cov teeb meem ntawm kev tiv thaiv tus nyom. Tab sis qee qhov kev vam meej hauv lawv daim ntawv thov yog pom tseeb.
Agapova L.L., kws kho plawv
Statins yog ib pawg tshuaj uas muaj nyob rau hauv cov npe tseem ceeb ntawm kev siv tshuaj tiv thaiv ch Chioolemia thiab qhov tshwm sim. Nrog lawv cov kev pab, nws yog ib qho ua tau kom txo qhov tuag ntawm txoj hlab ntsha tawg thiab plawv nres. Lub cim thib plaub yog suav hais tias yog cov siv tau zoo tshaj plaws thiab nyab xeeb.
Statins - yog dab tsi
Statins yog ib pawg tshuaj uas tsim los txo cov roj hauv cov ntshav. Tab sis cov tshuaj tsis cuam tshuam ncaj qha rau nws. Lawv cuam tshuam rau daim siab, inhibiting qhov zais cia ntawm ib qho enzyme uas koom nrog hauv kev tsim cov cholesterol.
Hauv tib neeg lub cev yog nws cov khoom siv - lipoproteins. Lawv muaj cov siab thiab tsis ceev. Yog tias cov txheej txheem metabolic tsis cuam tshuam, ces lipoproteins tsis ua kev puas tsuaj rau kev noj qab haus huv. Tab sis kev tshaj tawm roj ntau dhau ua rau kev tsim cov quav hniav, uas ua rau txoj kev txhim kho ntawm cov kab mob loj.
Statins yog tswj los txo tus naj npawb ntawm cov roj cholesterol mus rau cov ntaub so ntswg. Tib lub sijhawm, cov xov tooj ntawm cov qis lipoprotein receptors ntawm hepatocytes nce. Uas yog, lawv hloov cov cholesterol nyob rau hauv kev coj rov qab - los ntawm cov hlab ntsha mus rau lub siab. Ua tsaug rau cov tshuaj no, cov roj cholesterol tsim tawm tau zoo li qub. Lawv txoj kev siv ua rau coj nws cov ntsiab lus ib txwm siv.
Tseem Ceeb! Yuav siv cov roj (cholesterol) dab tsi coj rau statins rau? Lawv tsim nyog rau tus neeg muaj qhov ntsuas siab tshaj 5 mmol / l. Tom qab ib qho myocardial infarction, hauv cov kab mob plawv heev, cov phiaj xwm roj tsawg tsawg.
Nta ntawm kev faib tawm ntawm statins
Muaj ob peb txoj hauv kev los txheeb xyuas cov statins:
- Rau tiam: thawj, thib ob, thib peb thiab tiam tas los.
- Los ntawm keeb kwm: hluavtaws, semi-hluavtaws thiab ntuj.
- Raws li kev saib xyuas ntawm cov tshuaj nquag: txhaj ntau, nruab nrab thiab nrab koob.
Kev faib hom tom kawg yog qhov yooj yim tshaj plaws, vim tias cov statins tau sau tseg nyob rau hauv ntau yam koob tshuaj.
Tej yam ntuj tso roj ua kom ntshav qab zib
Txhawm rau txo cov ntshav hauv cov ntshav siab, yuav tsum noj cov zaub mov tshwj xeeb. Nws yog qhov tsim nyog, raws li qee cov zaub mov muaj lub ntuj statins.
Txo cov roj (cholesterol) uas tsis muaj tshuaj yog qhov ua tau nrog kev siv:
- Cov khoom muaj ascorbic acid. Cov no suav nrog cov txiv hmab txiv ntoo hauv paus, dub currants, hiav txwv buckthorn, sawv duav, qab kua txob.
- Cov khoom lag luam nrog nicotinic acid. Cov no yog txhua hom txiv ntoo, nqaij ntshiv, nqaij liab.
- Omega-3 fatty acids - liab ntses, txhua cov roj zaub.
- Polyconazole. Nws muaj nyob hauv kab tsib, thiab tuaj yeem muas hauv chaw muag tshuaj.
- Pectin. Nws qhov siab tshaj plaws tau sau tseg hauv txiv apples, carrots, zaub qhwv, taum, cereals, ceg.
- Resveratrol yog txiv hmab.
- Kov Txwv
Qej kuj tseem pab kom cov cholesterol tsawg.
Kuv puas yuav tsum tau haus statins thaum ua raws li kev noj haus tshuaj tiv thaiv kab mob? Khoom noj kom zoo yog ib feem ntawm txoj kev kho. Yog li, feem ntau ua rau kom muaj qhov xwm txheej, tus neeg mob hloov pauv kev noj haus thiab noj tshuaj ntawm pab pawg no.
Cov Yuav Tsum Muaj
Ua ntej tshaj plaws, pab pawg ntawm cov tshuaj no yog contraindicated rau cov poj niam thaum cev xeeb tub. Nws tseem raug txwv tsis pub siv lawv hauv cov xwm txheej zoo li no:
- kev ua xua tshwm sim, tus kheej tsis kam rau lub Cheebtsam ntawm cov tshuaj,
- mob raum tsis zoo
- kev ua tsis tiav ntawm cov tshuaj endocrine,
- pathology ntawm cov leeg tshuab hlwb hlau,
- kab mob siab.
Yog tias koj siv cov tshuaj statins ntev ntev hauv kev siv ntau npaum li cas, lawv tuaj yeem ua rau muaj kev mob tshwm sim:
- mob hauv lub plab zom mov,
- cem quav
- xeev siab thiab ntuav
- platelet tej,
- o ntawm lub sab sauv thiab qis dua extremities,
- thawj, rog,
- mob leeg
- rov qab mob
- sib koom tes kab mob.
Tsis tas li, kev sib raug zoo ntawm cov tshuaj nrog cov kev kho mob nyuaj yuav tsum tau muab rau hauv tus account. Kev siv cov tshuaj tsis haum nrog statins tuaj yeem ua rau muaj kev rau txim loj.
Tshaj tawm tuaj, nws yuav tsum raug sau tseg tias statins yog qhov muaj kev nyab xeeb thiab zoo tshuaj tau muab rau lawv siv raug. Thaum kuaj xyuas tus yam ntxwv ntawm lub cev, tus kab mob concomitant ntawm tus neeg mob, tus kws kho mob koom yuav xaiv txoj kev ua tau zoo tshaj plaws.