LIPRIMAR: kev txheeb xyuas

Lub sijhawm zoo thiab sijhawm ntawm lub hnub! Ntsib nrog teebmeem ntawm qhov hnyav dua, thawj cov kabmob ua rog, cov ntsiab lus ntawm cov kev kuaj pom pom tias muaj cov roj (cholesterol) ntau dhau! Cov khoom noj muaj txiaj ntsig, kev ua kis las tsis tau txav mus los ntawm qhov ntsuas ntawm qhov hnyav thiab, raws li, cov theem ntawm cov roj cholesterol hauv cov ntshav. Tom qab ntawd, tom qab ib nrab xyoo, kuv tau mus ntsib kws kho mob, Leprimar tau sau ntawv 1 ntsiav tshuaj thiab Metformin Teva. Hauv cov nyom, ob qho tshuaj no, haus 18 hnub thiab pub ntshav ntxiv - qhov ntsuas cov roj (cholesterol) tau pib poob thiab qhov ntim ntau dhau. Cov zaub mov tseem nyob nrog tus cwj pwm / tus cwj pwm, thiab lub cev hnyav mus thiab cov teeb meem ib yam nkaus. Liprimar ua vim yog atorvastatina uas muaj nyob hauv.

Cov xwm txheej xyoo dhau los ntawm cov kab mob plawv yog qhov txaus ntshai heev. Nws yog qhov tshwj xeeb tshaj yog txaus ntshai tias ib qho kab mob xws li lub plawv nres tsis raug kuaj, thiab koj tsis paub tias koj yuav ntsib nws lossis tsis. Thiab hauv peb tsev neeg nws tau poob siab thaum tus neeg noj qab nyob zoo hauv txhua qhov chaw, thaum kaum tsib feeb, tuag los ntawm kev tawm tsam. Kuv txiv tau mob plawv 6 lub hlis dhau los. Kev ua haujlwm tau ua tiav, thiab ntawm cov kev kho mob tau hais tawm Liprimar, Pfizer. Liprimar yog ib tus pabcuam uas pab cov neeg rov qab los ntawm kev mob plawv thiab tiv thaiv kom tsis txhob mob ntxiv, uas yog qhov tseem ceeb heev rau thawj xyoo, vim qhov no yog lub sijhawm pheej hmoo siab tshaj plaws. tej daim, hauv cov pob tsuas muaj peb lub hlwv. Rau cov neeg, zoo li peb, tau ntsib qhov teeb meem zoo li no, Kuv xav nco ntsoov tias cov tshuaj no tau muag ntawm luv nqi. nyeem lwm tus tsim khoom lag luam. Yuav kom ua qhov no, koj yuav tsum xyuas seb lawv puas koom rau hauv qhov chaw muag tshuaj hauv khw muag tshuaj, feem ntau lawv muaj cov ntawv nplaum rau ntawm lub txhab nyiaj ntsuab. Daim ntawv nug hnub tau sau tiav, koj yuav tau muab daim npav luv nqi, uas muab 20% luv nqi. Ib qho tsuas yog tsis muaj ntau lub chaw muag tshuaj koom nrog qhov kev pab no, yog li nrhiav seb lub tsev muag tshuaj twg koom nrog hauv koj lub nroog thiab qhov twg tsis yog. Cov lus qhia yog qhov loj heev, nws piav qhia, zoo li txhua yam tshuaj, nws cov lus pom zoo rau siv, kev phiv tshuaj. Ib zaug ntxiv, thov txim kuv tsis tau noj hom tshuaj no tsis tas muaj ntawv yuav tshuaj, nyob rau qhov twg ntau npaum li cas yuav tau qhia, txoj cai rau kev noj tshuaj, thiab tseem yuav tsum tau txais kev saib xyuas los ntawm tus kws kho mob. Thiab cia nws, yog tias koj tseem ntsib qhov kev puas tsuaj loj no, ncua koj lub neej thiab ua kom tsawg dua me ntsis, vim nws muaj mob. Thiab muaj ntau qhov kev txwv uas yuav tsum tau ua raws cai. Yuav tsum noj qab nyob zoo thiab cia lub khaum no kis los ntawm koj.

Cov xwm txheej xyoo dhau los ntawm cov kab mob plawv yog qhov txaus ntshai heev. Nws yog qhov tshwj xeeb tshaj yog txaus ntshai tias ib qho kab mob xws li lub plawv nres tsis raug kuaj, thiab koj tsis paub tias koj yuav ntsib nws lossis tsis. Thiab hauv peb tsev neeg nws tau poob siab thaum tus neeg noj qab nyob zoo hauv txhua qhov chaw, thaum kaum tsib feeb, tuag los ntawm kev tawm tsam. Kuv txiv tau mob plawv 6 lub hlis dhau los. Kev ua haujlwm tau ua tiav, thiab ntawm cov kev kho mob tau hais tawm Liprimar, Pfizer. Liprimar yog ib tus pabcuam uas pab cov neeg rov qab los ntawm kev mob plawv thiab tiv thaiv kom tsis txhob mob ntxiv, uas yog qhov tseem ceeb heev rau thawj xyoo, vim qhov no yog lub sijhawm pheej hmoo siab tshaj plaws. tej daim, muaj tsuas yog peb lub hlwv hauv pob. Rau cov neeg uas, zoo li peb, tau ntsib qhov teeb meem zoo li no, kuv xav nco ntsoov tias cov tshuaj no tau muag ntawm cov khw muag khoom luv nqi. Yuav kom ua qhov no, koj yuav tsum nrhiav hauv lub tsev muag tshuaj seb lawv puas koom nrog txoj haujlwm, feem ntau lawv muaj glues ntawm kev tshuaj xyuas lub sijhawm. Daim ntawv nug hnub tau sau tiav, koj yuav tau muab daim npav luv nqi, uas muab 20% luv nqi. Ib qho tsuas yog tsis muaj ntau lub chaw muag tshuaj koom nrog qhov kev pab no, yog li nrhiav seb lub tsev muag tshuaj twg koom nrog hauv koj lub nroog thiab qhov twg tsis yog. Cov lus qhia yog qhov loj heev, nws piav qhia, zoo li txhua yam tshuaj, nws cov lus pom zoo rau siv, kev phiv tshuaj. Ib zaug ntxiv, thov txim kuv tsis tau noj hom tshuaj no tsis tas muaj ntawv yuav tshuaj, nyob rau qhov twg ntau npaum li cas yuav tau qhia, txoj cai rau kev noj tshuaj, thiab tseem yuav tsum tau txais kev saib xyuas los ntawm tus kws kho mob. Thiab cia nws, yog tias koj tseem ntsib qhov kev puas tsuaj loj no, ncua koj lub neej thiab ua kom tsawg dua me ntsis, vim nws muaj mob. Thiab muaj ntau qhov kev txwv uas yuav tsum tau ua raws cai. Yuav tsum noj qab nyob zoo thiab cia lub khaum no kis los ntawm koj.

Nyob zoo cov phooj ywg! Thaum kuv tau txais lub caj dab vascular ultrasound. Tus kws kho mob tau saib ntawm cov hlab ntsha thiab tam sim ntawd nug: "Koj puas muaj cov roj cholesterol siab?" Kuv tau hnov lo lus roj, tab sis qhov tseeb tias nws tau tsa thiab qhov no raug rau kuv yog thawj zaug uas kuv tau ntsib. Nws muab tawm tias qhov teeb meem yuav tsum tau daws thiab kuv tau teem sijhawm nrog tus kws kho plawv. Tus kws kho mob hais rau kuv tias "cov roj" tsis zoo yog tso rau ntawm cov phab ntsa ntawm cov hlab ntshav, qhov no tsis zoo rau txhua yam kev mob plawv. Kuv tau sau cov tshuaj Asmeskas Liprimar los ntawm lub tuam txhab Pfizer. Lawv tau qhia kuv kom txo cov roj (cholesterol) nrog cov zaub mov hypocholesterol (Kuv tsis kam noj zaub mov rog), nrog rau kev nce ntxiv rau kev haus dej haus rau 2 litres ntawm cov dej zoo, + txwv siv ntsev rau 1 teev / liter ib hnub thiab tsis suav cov zaub mov kib, haus luam yeeb thiab pickled khoom. Lwm tus txiv nees. nyeem ntxiv, ua haujlwm lub cev ib txwm 5-7 zaug hauv ib lub lis piam, taug kev 10,000 kauj ruam hauv ib hnub, ua luam dej li 40 feeb, caij tsheb kauj vab, nce ntaiv li 15 feeb. Zoo, koj nkag siab txhua yam. ? Tus neeg ua haujlwm hauv chaw ua haujlwm muaj hom tsheb kauj vab zoo li cas. Tab sis kuv yeej pib coj Liprimar. Lub npe thoob ntiaj teb rau cov tshuaj no yog atorvastatin. Kuv tau noj tshuaj ntau npaum li 20 mg, Kuv yuav tsum tau noj txhua hnub tom qab noj hmo tas. Kuv txiav txim siab tam sim ntawd yuav ib pob ntawm 100 ntsiav tshuaj kom nws thiaj pheej yig dua thiab tsis tshua mus rau lub tsev muag tshuaj. Thiab kuv yuav nws. ntawm tus nqi uas tuaj yeem pom hauv daim duab. txog thaum ib hnub tshav ntuj nyob hauv Tsev Muag Tshuaj 36.6 lawv tau hais rau kuv tias muaj Kev Pab Txhawb Kev Mob Nkeeg thiab Kev Kawm Kev Kawm thiab lawv tau muab CARE rau koj daim npav txo nqi. Daim ntawv qhia tawm los ntawm Pfizer. Kuv tau teb cov lus nug, nkag mus rau kuv tus kheej cov ntaub ntawv, thiab rov qab tau txais tus nqi luv nqi ntawm qhov kev yuav khoom. Raws li cov ntaub ntawv los ntawm tus kws muag tshuaj, koj tuaj yeem tau txais cov luv nqi ntawm ob pob nyob hauv ib hlis. Yog li, kev yuav khoom ntawm 100 ntsiav tshuaj yuav raug nqi rau kuv txog 700 rubles. Siv tshuaj nkaus xwb raws li kws kho mob hais. Tom qab noj Liprimar rau 1 hlis, kuv qhov ntsuas tau rov qab zoo li qub. Kuv coj mus kuaj ntshav biochemical ob zaug: ua ntej thiab tom qab. Qhov tshwm sim tau zoo, ntseeg kuv. Atorvastatin yuav tsum tsis txhob noj thaum cev xeeb tub, lossis yog tias koj npaj muaj menyuam, kev txwv hnub nyoog (koj tsis tuaj yeem yog tsawg dua 18 xyoo), nws tsis tsim nyog yuav haus cawv nrog cawv (thiab nws tsis ua li cas, muaj ntau yam haujlwm tseem ceeb thiab lwm yam uas nqa tuaj kev lom zem). Kuv tsis xav tias muaj kev phiv hais txog kev nyab xeeb. Nws tau sau rau hauv cov lus qhia uas cuam tshuam rau daim siab, yog li koj yuav tsum tswj cov ntsuas thiab tom qab pib coj mus kuaj ntshav dua tom qab ib hlis. Qhov kev tsis zoo suav nrog tus nqi siab, tab sis nrog cov qhua tuaj noj mov txhawb nqa kev pab cuam, txhua yam tsis phem. Raws li cov ntaub ntawv los ntawm Pfizer lub vev xaib, "The Care for You Program" tau pib thaum Lub Ib Hlis 2010. Tam sim no, Pfizer cov koom tes hauv Qhov Kev Pab Cuam yog cov chaw muag tshuaj sib koom tes nrog tag nrho kwv yees li ntawm 9,000 chaw muag tshuaj hauv 71 thaj chaw hauv Russia. Kuv hais rau kuv tias Liprimar pom tias yog qhov tshuaj zoo tshaj plaws thiab muaj cov kev mob tshwm sim tsawg dua li lwm cov tshuaj. Kuv tsis tau noj lwm yam tshuaj thiab tsis muaj dab tsi piv rau. Ib yam kuv tuaj yeem hais yog tias kuv tsis txuag kev noj qab haus huv, uas yog qhov kuv xav koj. Noj qab nyob zoo thiab zoo siab!

Nyob zoo cov phooj ywg! Thaum kuv tau txais lub caj dab vascular ultrasound. Tus kws kho mob tau saib ntawm cov hlab ntsha thiab tam sim ntawd nug: "Koj puas muaj cov roj cholesterol siab?" Kuv tau hnov lo lus roj, tab sis qhov tseeb tias nws tau tsa thiab qhov no raug rau kuv yog thawj zaug uas kuv tau ntsib. Nws muab tawm tias qhov teeb meem yuav tsum tau daws thiab kuv tau teem sijhawm nrog tus kws kho plawv. Tus kws kho mob hais rau kuv tias "cov roj" tsis zoo yog tso rau ntawm cov phab ntsa ntawm cov hlab ntshav, qhov no tsis zoo rau txhua yam kev mob plawv. Kuv tau sau cov tshuaj Asmeskas Liprimar los ntawm lub tuam txhab Pfizer. Lawv tau qhia kuv kom txo cov roj (cholesterol) nrog cov zaub mov hypocholesterol (Kuv tsis kam noj zaub mov rog), nrog rau kev nce ntxiv rau kev haus dej haus rau 2 litres ntawm cov dej zoo, + txwv siv ntsev rau 1 teev / liter ib hnub thiab tsis suav cov zaub mov kib, haus luam yeeb thiab pickled khoom. Tseem, qhov tseeb, kev tawm dag zog ib txwm 5-7 zaug hauv ib lub lis piam, taug kev 10,000 kauj ruam hauv ib hnub, ua luam dej li 40 feeb, caij tsheb kauj vab, nce ntaiv li 15 feeb. Zoo, koj nkag siab txhua yam. ? Tus neeg ua haujlwm hauv chaw ua haujlwm muaj hom tsheb kauj vab zoo li cas. Tab sis kuv yeej pib coj Liprimar. Lub npe thoob ntiaj teb rau cov tshuaj no yog atorvastatin. Kuv tau noj tshuaj ntau npaum li 20 mg, Kuv yuav tsum tau noj txhua hnub tom qab noj hmo tas. Kuv txiav txim siab tam sim ntawd yuav ib pob ntawm 100 ntsiav tshuaj kom nws thiaj pheej yig dua thiab tsis tshua mus rau lub tsev muag tshuaj. Thiab kuv yuav nws. ntawm tus nqi uas tuaj yeem pom hauv daim duab. txog thaum ib hnub tshav ntuj nyob hauv Tsev Muag Tshuaj 36.6 lawv tau hais rau kuv tias muaj Kev Pab Txhawb Kev Mob Nkeeg thiab Kev Kawm Kev Kawm thiab lawv tau muab CARE rau koj daim npav txo nqi. Daim ntawv qhia tawm los ntawm Pfizer. Kuv tau teb cov lus nug, nkag mus rau kuv tus kheej cov ntaub ntawv, thiab rov qab tau txais tus nqi luv nqi ntawm qhov kev yuav khoom. Raws li cov ntaub ntawv los ntawm tus kws muag tshuaj, koj tuaj yeem tau txais cov luv nqi ntawm ob pob nyob hauv ib hlis. Yog li, kev yuav khoom ntawm 100 ntsiav tshuaj yuav raug nqi rau kuv txog 700 rubles. Siv tshuaj nkaus xwb raws li kws kho mob hais. Tom qab noj Liprimar rau 1 hlis, kuv qhov ntsuas tau rov qab zoo li qub. Kuv coj mus kuaj ntshav biochemical ob zaug: ua ntej thiab tom qab. Qhov tshwm sim tau zoo, ntseeg kuv. Atorvastatin yuav tsum tsis txhob noj thaum cev xeeb tub, lossis yog tias koj npaj muaj menyuam, kev txwv hnub nyoog (koj tsis tuaj yeem yog tsawg dua 18 xyoo), nws tsis tsim nyog yuav haus cawv nrog cawv (thiab nws tsis ua li cas, muaj ntau yam haujlwm tseem ceeb thiab lwm yam uas nqa tuaj kev lom zem). Kuv tsis xav tias muaj kev phiv hais txog kev nyab xeeb. Nws tau sau rau hauv cov lus qhia uas cuam tshuam rau daim siab, yog li koj yuav tsum tswj cov ntsuas thiab tom qab pib coj mus kuaj ntshav dua tom qab ib hlis. Qhov kev tsis zoo suav nrog tus nqi siab, tab sis nrog cov qhua tuaj noj mov txhawb nqa kev pab cuam, txhua yam tsis phem. Raws li cov ntaub ntawv los ntawm Pfizer lub vev xaib, "The Care for You Program" tau pib thaum Lub Ib Hlis 2010. Tam sim no, Pfizer cov koom tes hauv Qhov Kev Pab Cuam yog cov chaw muag tshuaj sib koom tes nrog tag nrho kwv yees li ntawm 9,000 chaw muag tshuaj hauv 71 thaj chaw hauv Russia. Kuv hais rau kuv tias Liprimar pom tias yog qhov tshuaj zoo tshaj plaws thiab muaj cov kev mob tshwm sim tsawg dua li lwm cov tshuaj. Kuv tsis tau noj lwm yam tshuaj thiab tsis muaj dab tsi piv rau. Ib yam kuv tuaj yeem hais yog tias kuv tsis txuag kev noj qab haus huv, uas yog qhov kuv xav koj. Noj qab nyob zoo thiab zoo siab!

Pharmacodynamics thiab pharmacokinetics

Kev nqus liprimar txo qib roj, thiab raws li nws cov khoom lag luam hauv lub siab. Yog li ntawd, nws yog qhov tsim tawm rau txais thiab muaj keeb hypercholesterolemiahom sib xyaw dyslipidemia thiab yog li ntawd.

Qhov ua tau zoo ntawm cov tshuaj no tau tshwm sim hauv homozygous tsev neeg daim ntawv ntawm hypercholesterolemia, thaum kho nrog cov tshuaj tiv thaiv hypolipidemic zoo tsis tuaj yeem tshwm sim. Liprimar tseem tseem siv tau los kho cov neeg mob kev txom nyem los ntawm angina pectoris thiab lwm yam cuam tshuam hauv cov hlab plawv, uas txo cov kev pheej hmoo ntawm txoj kev loj hlob ischemiateeb meem thiab kev tuag.

Thaum noj sab hauv atorvastatin zoo nqus tau sau tseg. Qhov siab tshaj plaws nyob rau hauv ntshav tau txog tom qab 2 teev thiab nyob ntawm qhov ntau npaum li cas.

Noj mov tsis muaj lub cev tshwj xeeb rau lub bioavailability ntawm qhov chaw. Tib lub sijhawm, hais txog 98%atorvastatin los rau hauv kev sib cuag nrog cov ntshav protein. Raws li qhov tshwm sim ntawm cov metabolism hauv cov feem tseem ceeb, cov tshuaj pharmacologically active tau tsim, qhov excretion ntawm uas tshwm sim nrog kua tsib thiab me ntsis nrog zis.

Kev taw qhia Liprimar

Cov cim tseem ceeb rau kev siv Liprimar:

ntau hom hypercholesterolemia, hyperlipidemia, dibetalipoproteinemia, hypertriglyceridemia,
kev tiv thaiv ntawm cov kab mob plawv hauv cov neeg mob nrog lossis tsis muaj tus tsos mob tsis txaus siab, tab sis nrog cov cim kev kuaj mob ntawm txoj kev txhim kho tau myocardial infarction, angina pectoris, mob stroke thiab yog li ntawd.

Cov Yuav Tsum Muaj

Cov tshuaj tsis tau sau tseg rau:

siab rhiab rau nws lub Cheebtsam,
cov kab mob nquag thiab mob siab lub siab,
tsis tau muaj hnub nyoog 18 xyoo.

Nws kuj tseem yuav tsum tau sau npe Liprimar nrog ceev faj rau cov neeg mob uas quav cawv thiab raug mob rau daim siab mob.

Sab sij huam

Raws li txoj cai, cov neeg mob zam Liprimar zoo, tab sis kev txhim kho ntawm cov kev mob tshwm sim yuav tsum tsis txhob txiav txim siab.

Qee zaum siv cov tshuaj no tuaj yeem ua rau muaj kev phiv tshuaj uas cuam tshuam rau kev ua haujlwm ntawm lub paj hlwb: mob taub hauteeb meem pw asthenic mob ntsws.

Kuj muaj peev xwm: xeev siab, zawv plabmob plabcem quav, dyspepsia, mob plabCov. Kev cuam tshuam hauv kev ua haujlwm ntawm cov leeg ua haujlwm thiab qhov mob ntawm cov nqaij sib txuas tau tshwm sim.

Muaj qee zaus, ceeb toom: amnesia, paresthesia, peripheral neuropathy, hypesthesia, tsis nco qab, kab mob siab, mob cholestatic daj ntseg,kev fab tshuaj tsis haum thiab yog li ntawd.

Liprimar - cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Raws li cov lus qhia rau kev siv Liprimar, cov ntsiav tshuaj no yog npaj rau kev tswj hwm ntawm qhov ncauj. Pib kev kho mob atorvastatin, pre-txiav txim siab txog qib cov roj hauv cov ntshav, thiab tom qab ntawd tau sau ntawv tawm kev noj haus thiab kev tawm dag zog. Liprimar feem ntau pom zoo thaum lwm txoj kev siv tshuaj tsis ua haujlwm.

Qhov kev nqus tau ntawm cov tshuaj no tsis vam khom rau kev noj zaub mov thiab lub sijhawm nruab hnub. Hauv qhov no, qhov tshuaj txhua hnub koom nrog ib koob. Tom qab 2-4 lub lis piam, kev hloov kho ntau ntau yog ua tau, ntawm kev txiav txim ntawm tus kws kho mob koom. Kev txhim kho ntawm kev ua kom zoo li qub tau sau tseg tom qab 2 lub lis piam. Qhov siab tshaj plaws yog tau tiav tom qab ib hlis txij li hnub pib tswj hwm.

Kev kho liprimar tuaj yeem nce cov kev ua haujlwm ntawm daim siab enzymes, yog li, kev soj ntsuam daim siab ua haujlwm yog yuav tsum tau ua lub sijhawm no.

Kev sib txuam

Concomitant siv nrog cyclosporine, fibrates, erythromycin, clarithromycinantifungal tus neeg sawv cev thiab nicotinic acid tuaj yeem ua rau muaj kev pheej hmoo ntawm kev tsim myopathies.

Sib txuam ua ke atorvastatin nrog cytochrome isoenzyme CYP3A4, erythromycin, clarithromycin, diltiazem tsub kom lub siab ntawm ib yam khoom hauv ntshav ntshav.

Ua ke nrog kev npaj muaj magnesium hydroxide lossis aluminium hydroxidexyab ntawv thiab colestipol tej zaum yuav ua rau poob qisatorvastatin nyob rau hauv kev sib xyaw ntawm cov ntshav ntshav.

Kev sib xyaw ntawm cov tshuaj no nrog digoxin thiab tshuaj tiv thaiv qhov ncaujmuaj norethisteronethiab ethinyl estradiolsignificantly nce lawv concentration nyob rau hauv lub cev.

Krestor lossis Liprimar - uas zoo dua?

Raws li cov kws tshaj lij, txoj kev kho mob yuav tsum tau nqa nrog cov tshuaj qub uas muaj kev kuaj pom tseeb txog lawv cov hauj lwm zoo li cov statins uas cuam tshuam rau lub xeev ntawm cov hlab plawv.Cov tshuaj qub muaj xws li: Zokor, Liprimar thiab Neeg Coob.

Ntxiv mus, hauv kev coj ua, kev sib cuam tshuam ntawm cov tshuaj no feem ntau raug tso cai, txij li lawv muaj yuav luag tib cov txiaj ntsig.

Tsis muaj qhov kev cuam tshuam ncaj qha rau kev haus cawv thaum kho nrog cov tshuaj no, tab sis txij li cawv yog ib lub nra ntxiv rau daim siab, nws yog qhov zoo dua rau qhov tsis kam haus cawv.

Kev txheeb xyuas ntawm Liprimar

Cov tshuaj no feem ntau tau kho rau cov neeg raug kev txom nyem los ntawm ntau yam kev cuam tshuam ntawm cov hlab plawv cov ntshav. Tib lub sijhawm, tus neeg mob tshuaj xyuas txog Liprimar muaj qhov sib txawv. Feem ntau tsis tshua muaj ntawv ceeb toom piav qhia txog qhov txiaj ntsig ntawm kev kho mob.

Txawm li cas los xij, qee tus neeg mob tsis txaus siab tias, thaum sau ntawv yuav cov tshuaj no, cov kws tshaj lij tsis tau piav qhia txog yuav ua li cas kom noj cov tshuaj kom raug. Yog li, lawv sim ua kom ywj siab xaiv, thiab feem ntau kho cov ntau npaum. Yog li ntawd, ntau cov tsos mob txawv txawv rau Liprimaru pib tshwm sim - ntshav ntshav, ua pob thiab doog ntshav, thiab lwm yam.

Raws li cov kws kho mob, cov tshuaj no yog ib qho ua tau zoo tshaj plaws, muab tau tias qhov tau muab tshuaj ntau npaum li cas, kev coj noj coj ua thiab lub sijhawm kho yog nruj. Yog tias qee yam ua tsis tiav rau cov neeg mob, tom qab ntawd koj tuaj yeem qhia meej tas nrho cov yam ntxwv ntawm kev kho ntawm tus kws kho mob uas koom nrog. Tsis tas li ntawd, nyob rau lub sijhawm kev kho mob, nws yog ib qhov tsim nyog los soj ntsuam lub xeev cov ntshav, ua raws li kev noj zaub mov zoo thiab ua kom lub cev tsim nyog.

Kev qhia rau kev siv tshuaj

thawj, cov txheeb ze thiab tsis-tsev neeg hypercholesterolemia (cov roj (ntshav muaj roj ntau ntxiv hauv cov ntshav),
kev tiv thaiv cov kab mob plawv,
kev tiv thaiv kab mob plawv thawj thiab theem siab
ntxiv rau kev noj haus tshwj xeeb,
kev tiv thaiv ntawm myocardial infarction,
kev tiv thaiv mob stroke.

Kev tshuaj pom qhov tsis zoo txog qhov tshuaj nyob rau hauv nqe lus nug

Zoo li txhua yam tshuaj, cov tshuaj "Liprimar" thiab tshuaj xyuas tsis zoo. Muaj feem pua me me ntawm cov neeg mob uas cov tshuaj no tsis haum. Qhov no yog vim qee tus yam ntxwv ntawm lub cev. Cov neeg uas tau ntsib qhov tshwm sim ntawm cov tshuaj ntawm lawv tus kheej, nco ntsoov qhov tsis zoo uas lawv tau ntsib lub sijhawm kho nrog cov tshuaj no. Qhov tsis zoo muaj xws li tus nqi siab ntawm cov tshuaj no. Ib pob raug nqi txog 600 rubles. Qhov thib ob "rho tawm" ntawm cov tshuaj yog lub sijhawm ua haujlwm kho. Cov tshuaj Liprimar, cov neeg mob tshuaj xyuas kom paub tseeb txog qhov no, nws yog ib qho tsim nyog coj nws rau lub neej. Yog li, kev kho mob nrog cov tshuaj saum toj saud yuav tsum tau nyiaj ntau. Cov kev mob tshwm sim ua rau qee tus neeg mob qee qhov tsis yooj yim, xws li tsaug zog, kiv taub hau, thiab xeev siab.

Cov kws kho mob cov lus pom zoo rau cov tshuaj no, cov lus pom zoo thiab xaus lus

Yuav kom tau txais cov ntaub ntawv tiav ntau tshaj plaws txog cov tshuaj no, koj yuav tsum paub lub tswv yim ntawm cov kws tshwj xeeb txog nws. Cov tshuaj Liprimar, cov kev tshuaj xyuas ntawm cov kws kho mob hais txog kev ua kom muaj kev cia siab, pom tau tias yog ib qho tshuaj zoo. Cov kws kho mob tau sau nws nrog kev noj haus, muab ib qho kev coj ua tsis zoo thiab tsom kwm cov kab mob kom tau so zoo. Ua raws li cov lus pom zoo ntawm tus kws kho mob uas tuaj koom, ntau pua tus neeg mob txhim kho lawv li kev noj qab haus huv, txo cov roj cholesterol thiab zam lub plawv nres. Qhov mob tseem ceeb rau cov kws kho mob yog lub sijhawm ntsuas ntshav siab thiab kuaj ntshav tas li. Yog li, cov tshuaj no yeej pab txhim kho kev noj qab haus huv thiab txo cov roj hauv lub cev, tab sis koj yuav tsum noj nws tsis tu ncua thoob plaws koj lub neej.

Cov Tshuaj Pharmacokinetics

Liprimar, thaum noj ntawm qhov ncauj, zoo adsorbed los ntawm daim siab, nce mus txog cov ntshav siab kawg plasma ntau tom qab 2 teev. Lub plasma concentration ntawm cov tshuaj yog sib npaug rau cov koob tshuaj coj (hauv thaj tsam ntawm 10-20-40-80 mg). Qhov tseeb txog kev noj qab haus huv ntawm cov ntsiav tshuaj, hauv kev sib piv nrog txoj kev daws teeb meem, yog 95-99%, cov txheej txheem hauv lub cev yog 30% (qhov ntsuas no tau cuam tshuam nrog kev txiav tawm ntawm lub cev ntawm atorvastatin nyob rau hauv txoj hnyuv thiab cov nyhuv ntawm nws cov lus pom dhau los ntawm lub siab). Thaum noj cov tshuaj nrog zaub mov, muaj qee yam me me hauv kev nyab xeeb.

Kev sib txuas lus nrog cov ntshav plasma protein - 98%. Hauv kev ua tiav ntawm cov kab mob hepatic, qhov tsim muaj cov tshuaj pharmacologically nquag tshwm sim (kwv yees li 70% ntawm kev kho mob ntawm cov tshuaj pom tau hais tias vim nws cov roj ntsha hloov mus rau lub cev).

Atorvastatin feem ntau ua rau txoj hnyuv txuas nrog cov kua tsib. Nrog rau lub raum - tsuas yog 2%. Txawm li cas los xij, qhov tseem ceeb ntawm kev nkag mus ua ib qho recirculation tsis pom. Ib nrab-lub neej ntawm cov khoom xyaw nquag yog 14 teev. Lub sijhawm ntawm cov kev kho mob (vim yog metabolites ncig hauv cov ntshav) yog 20-30 teev.

Hauv cov neeg mob ntawm cov xyoo dhau los, hauv kev sib piv nrog cov ntxhais hluas thiab cov txiv neej, qhov nce ntawm ntshav plasma concentration ntawm atorvastatin tau sau tseg.

Cov hlwv ua haujlwm tsis zoo tsis cuam tshuam cov pharmacokinetics ntawm cov tshuaj. Thaum lub siab ua haujlwm tsis ua haujlwm nyob rau hauv cov ntshav ntshav, cov qib ntawm qhov tsis hloov pauv ntawm lub cev yuav nce ntau.

Nrog saib xyuas

Hauv cov neeg mob uas quav cawv, nyob hauv cov neeg mob uas muaj keeb kwm muaj kab mob siab.

Hauv cov neeg mob uas muaj kev pheej hmoo rau rhabdomyolysis (lub raum tsis ua haujlwm, hypothyroidism, kev mob caj ces rau cov leeg mob hauv keeb kwm ntawm tus neeg mob lossis tsev neeg keeb kwm, cov tshuaj lom los ntawm HMG-CoA reductase inhibitors (statins) lossis fibrates ntawm cov leeg nqaij, keeb kwm muaj kab mob siab thiab / lossis cov neeg mob uas haus cov dej cawv ntau, ntau dua 70 xyoo, cov xwm txheej uas nce ntshav ntau dua ntawm atorvastatin xav tau (piv txwv li, kev sib cuam tshuam nrog lwm cov tshuaj) txhais tau tias)).

Tsuas tshuaj thiab tswj hwm

Laprimar yog ntsiav tshuaj npaj npaj rau kev siv sab hauv. Siv sijhawm twg los xij ntawm hnub, tsis hais noj zaub mov.

Ua ntej pib kev kho mob nrog Liprimar, ib qho yuav tsum sim ua kom tiav kev tswj hwm ntawm hypercholesterolemia nrog kev pab ntawm kev noj zaub mov, ua kom tawm dag zog thiab hnyav rau cov neeg mob rog, nrog rau kev kho mob rau lwm tus kab mob.

Thaum sau tshuaj, tus neeg mob yuav tsum pom zoo rau ib qho kev noj haus hypocholesterolemic noj, uas nws yuav tsum ua raws li lub sijhawm hloov kho.

Qhov ntau npaum li cas ntawm cov tshuaj nws txawv ntawm 10 mg rau 80 mg ib hnub ib zaug thiab yog titrated noj rau hauv qhov kev txiav txim siab ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab tus neeg teb rau kev kho.

Qhov siab tshaj plaws niaj hnub noj tshuaj yog 80 mg.

Thaum pib ntawm kev kho mob thiab / lossis thaum lub sijhawm nce ntxiv ntawm Liprimar, nws yog ib qho tsim nyog los soj ntsuam cov tshuaj tua ntshav ntawm cov ntshav lipids txhua 2-4 lub lis piam thiab kho cov koob tshuaj raws li.

Heterozygous tsev neeg hypercholesterolemia

Qhov tshuaj thawj zaug yog 10 mg rau ib hnub. Cov koob tshuaj yuav tsum tau xaiv ib tus zuj zus thiab ntsuas qhov tseeb ntawm qhov koob tshuaj txhua 4 lub lis piam nrog kev nce ntxiv txog 40 mg ib hnub twg. Tom qab ntawd, txawm tias lub koob tshuaj yuav raug nce ntxiv txog qhov siab tshaj ntawm 80 mg rau ib hnub, lossis nws yog ua tau kom sib txuas cov tshuaj tiv thaiv kab mob sib ntxiv nrog kev siv atorvastatin ntawm ib koob ntawm 40 mg ib hnub.

Kev Tiv Thaiv Kab Mob Tiv Thaiv Kab Mob

Hauv kev tshawb nrhiav ntawm kev tiv thaiv kev tiv thaiv thawj zaug, koob tshuaj atorvastatin yog 10 mg rau ib hnub. Qhov koob tshuaj ntxiv yuav tsim nyog kom ua tiav LDL-C tus nqi raws li cov lus qhia tam sim no.

Siv rau hauv cov menyuam yaus ntawm 10 txog 18 xyoo nrog rau kev tiv thaiv heterozygous tsev neeg hypercholesterolemia

Qhov pom zoo kom pib noj yog 10 mg ib hnub ib zaug. Qhov kev txhaj tshuaj yuav raug nce ntxiv mus rau 20 mg ib hnub twg, nyob ntawm qhov siv los soj ntsuam. Kev paub nrog ib koob ntau tshaj 20 mg (sib haum rau ib koob ntawm 0.5 mg / kg) yog txwv.

Cov koob tshuaj ntawm cov tshuaj yuav tsum yog titrated nyob ntawm lub hom phiaj ntawm kev kho lipid-txo qis. Kev hloov koob tshuaj yuav tsum tau ua ntawm ncua sij hawm ntawm 1 lub sijhawm hauv 4 lub lis piam lossis ntau dua.

Siv nrog rau lwm cov tshuaj

Yog tias tsim nyog, kev siv sib xyaw nrog cyclosporine, telaprevir lossis kev sib xyaw ntawm tipranavir / ritonavir, koob tshuaj Liprimar yuav tsum tsis pub tshaj 10 mg / hnub.

Kev ceev faj yuav tsum tau siv thiab kev siv tshuaj qis tshaj plaws ntawm atorvastatin yuav tsum tau siv thaum nws siv nrog HIV tiv thaiv kab mob tiv thaiv kab mob siab, kab mob siab C protease inhibitors (boceprevir), clarithromycin thiab itraconazole.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Liprimar muaj nyob rau hauv cov qauv ntawm cov yeeb yaj kiab-cov ntsiav tshuaj nrog cov ntsiab lus ntawm 10 mg, 20 mg, 40 mg thiab 80 mg ntawm cov tshuaj xyaw nquag. Cov ntsiav tshuaj tau ntim rau hauv 7 lossis 10 ntsiav tshuaj hauv aluminium lossis PVC blisters rau 2-5 lossis 8, 10 blisters hauv ib pob.

Cov tshuaj ntawm cov ntsiav tshuaj suav nrog kev ua haujlwm ntawm atorvastatin.

Cov kuaj mob thiab pab pawg tshuaj: lipid-txo tshuaj.

Dab tsi pab Liprimar los ntawm?

Kev qhia siv rau cov mob no:

hypercholesterolemia,
tag nrho hyperlipidemia,
dibetalipoproteinemia,
hypertriglyceridemia,
cov tsos mob ntawm ischemic mob plawv.

Tsis tas li, kev qhia rau kev teem caij yog qhov muaj kev pheej hmoo loj ntawm kev mob plawv mob ntshav (lub hnub nyoog tshaj 55 xyoos, haus luam yeeb, mob ntshav qab zib, mob caj ces, kub siab, thiab lwm yam).

Pharmacological kev txiav txim

Liprimar yog ib qho tshuaj lipid-txo qis. Liprimar muaj atorvastatin, xaiv sib tw inhibitor ntawm 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA), uas tswj kev hloov pauv ntawm HMG-CoA rau mevalonate.

Liprimar pab txo cov roj lipoproteins uas tsis muaj roj ntau ntau thiab triglycerides, ntxiv rau qee qhov nce ntxiv hauv qib uas muaj lipoproteins ntau. Atorvastatin tau txais txiaj ntsig zoo rau cov neeg mob uas muaj homozygous tsev neeg daim ntawv ntawm hypercholesterolemia, hauv kev kho mob nrog cov tshuaj hypolipidemic tsis zoo.

Cov lus qhia rau kev siv

Raws li cov lus qhia rau kev siv, Liprimar noj ntawm qhov ncauj txhua lub sijhawm ntawm hnub, tsis hais noj zaub mov.

Qhov ntau npaum li cas ntawm cov tshuaj sib txawv ntawm 10 mg txog 80 mg 1 lub sijhawm / hnub, xaiv cov koob tshuaj yuav tsum tau nqa tawm mus rau hauv tus account thawj cov ntsiab lus ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ntawm tus kheej. Qhov siab tshaj plaws yog 80 mg 1 zaug / hnub.
Thaum pib kho thiab / lossis thaum lub sijhawm nce ntxiv ntawm Liprimar, nws yog qhov yuav tsum tau saib xyuas cov ntshav lipid cov ntsiab lus txhua 2-4 lub lis piam thiab kho qhov tshuaj raws li.

Tsis tas li, ua ntej pib kev kho mob nrog Liprimar, koj yuav tsum sim ua kom tiav kev tswj hwm ntawm hypercholesterolemia nrog kev noj zaub mov zoo, kev tawm dag zog thiab kev poob phaus hauv cov neeg mob rog, nrog rau kev kho mob hauv qab. Thaum muab tshuaj rau, cov neeg mob yuav tsum pom zoo rau kev noj zaub mov hypocholesterolemic noj, uas nws yuav tsum tau ua raws thaum lub sijhawm kho.

Pom tau tsa tes yeeb ncuab MUSHROOM ntawm ntsia hlau! Koj cov ntsia hlau yuav raug ntxuav hauv 3 hnub! Coj nws.

Yuav ua li cas kom ceev cov leeg nrawm tom qab 40 xyoo? Daim ntawv qhia yooj yim, sau cia.

Nkees hemorrhoids? Muaj ib txoj kev tawm! Nws tuaj yeem raug kho nyob hauv tsev hauv ob peb hnub, koj xav tau.

Txog qhov muaj cov cab li hais tias ODOR los ntawm lub qhov ncauj! Ib zaug ib hnub, haus dej nrog ib tee ..

Sab sij huam

Cov tshwm sim tsis zoo:

Hematopoietic system: tsis tshua muaj - thrombocytopenia,
Nruab nrab hauv lub paj hlwb: mob taub hau, insomnia, asthenic syndrome,
Lub plab zom mov: feem ntau - mob plab, pom pob, mob plab, xeev siab, raws plab, cem quav, tsis tshua muaj - ntuav, cholestatic jaundice, pancreatitis, mob siab, mob ntshav qab zib, tsis nco qab,
Kev tsis haum tshuaj: tawv nqaij ua pob, ua pob ua pob khaus, pruritus, urticaria, erythema multiforme, tshuaj tiv thaiv anaphylactic, tshuaj lom rau daim tawv nqaij ua kom haum,
Musculoskeletal system: feem ntau - myalgia, tsis tshua muaj - myositis, mob leeg, myopathy, rhabdomyolysis, mob rov qab, mob pob txha,
Kev tiv thaiv kab mob: hyperglycemia, hypoglycemia, nce ntxiv ntawm cov ntshav creatine phosphokinase,
Lwm yam: tsis tshua muaj - mob hauv siab, tsis muaj zog, mob nkees, ua kom hnyav, tinnitus, alopecia, mob raum tsis ua haujlwm, mob pob txha txha.

Yeej, cov tshuaj zoo tiv thaiv. Cov kev mob tshwm sim, yog tias lawv tshwm sim, feem ntau muaj qhov hnyav me ntsis thiab qhov ua cim pauv. Yog tias koj cov leeg ua kom tsis muaj zog lossis tsis hnov mob, tshwj xeeb yog nrog kub taub hau lossis malaise, tus neeg mob maj nrawm xav mus ntsib kws kho mob.

Analogs ntawm Liprimar

Cov qauv ntawm cov qauv ua haujlwm:

Tus tub sab
Atocord
Cov Atomax
Cov Ator
Atorvastatin
Atorvox
Atoris
Vazator
Lipona
Lipoford
Liptonorm,
Novostat,
Torvazin
Thorvacard
Torvalip
Keebkwm
Tulip.

Xim: kev siv cov analogues yuav tsum pom zoo nrog tus kws kho mob koom.

Tus nqi nruab nrab ntawm LIPRIMAR, ntsiav tshuaj hauv cov khw muag tshuaj (Moscow) yog 730 rubles.

Cov nqi rau lypimar hauv khw muag tshuaj hauv Moscow

zaj duab xis-ntsiav tshuaj ntsiav tshuaj	10 mg	100 pcs	≈ 1687 rub.
	10 mg	30 pcs	735 txhuam.
	20 mg	100 pcs	≈ 2587.9 rubles.
	20 mg	30 pcs	≈ 1056 rub.
	40 mg	30 pcs	≈ 1080 rubles
	80 mg	30 pcs	≈ 1,205,5 rubles

Kev tshuaj xyuas ntawm cov kws khomob txog lypimar

Ntsuam Xyuas 4.6 / 5

Txij nkawm

Nqe / zoo

Sab sij huam

Kuv siv thawj Liprimar nrog cov nyhuv txaus hauv txoj kev kho mob ntawm kev kho erectile kawg los ntawm atherosclerosis, dyslipidemia. Tom qab ob peb lub hlis ntawm kev noj tshuaj zoo raug sau tseg. Qhov siv tshuaj tiv thaiv tsawg kawg yog 20 mg rau ib hnub. Yuav tsum tau soj ntsuam kev kho lipid! Tus nqi zoo tshaj plaws rau cov nyiaj.

Qhov xav tau ntawm kev ncua ntev, ntau tas mus li, kev txais neeg kawm. Qhov ntxim nyiam ntawm kev ua rau daim siab ua haujlwm, ua kom muaj kev nyuaj siab. Hauv qee qhov tsis tshua muaj tshwm sim - kev ua paug ntawm cov tsos mob ntawm lub erection tivthaiv. Tab sis nws yuav tsum nkag siab tias cov kev mob tshwm sim rau tsawg dua 1% ntawm cov neeg mob Liprimar.

Yuav tsum muaj kev nkag siab txog cov kab mob pathophysiological li nram no: kev tsis zoo ntawm kev txhim kho erection thaum lub sij hawm atherosclerosis cuam tshuam tsis tsuas yog muaj qhov tsis zoo ntawm cov nyiaj - tawm mus rau tus qau los ntawm cov hlab ntsha, tab sis kuj nrog qhov tsis zoo ntawm cov noob qes, qhov tseem ceeb tshaj plaws txiv neej pw ua ke, testosterone, yog tsim.

Ntsuam xyuas 3.8 / 5

Txij nkawm

Nqe / zoo

Sab sij huam

Cov kev mob tshwm sim muaj tsawg heev. Cov teeb meem uas muaj tus kab mob hepatic enzymes muaj tsawg heev. Yeej tsis muaj ib yam dab tsi cuam tshuam nrog tus mob ntshav qab zib hauv kuv qhov kev xyaum.

Atorvastatin yog ib qho ua haujlwm thiab kev nyab xeeb, coj mus rau hauv tus account siab ua haujlwm, tus nees ntawm cov kev kho plawv niaj hnub. Cov koob tshuaj ua haujlwm yog 20-40 mg ib hnub twg, tshwj xeeb tshaj yog rau cov neeg mob uas muaj pov thawj txoj hlab ntsha hauv lub cev. Ib koob tshuaj 80 mg tuaj yeem siv tsuas yog ib txoj kev thauj khoom txhawm rau tswj cov quav hniav hauv cov neeg mob ACS. Kuv nug cov npoj yaig tsis txhob siv cov lus qhia hais txog kev siv cov tshuaj tiv thaiv loj ntawm atorvastatin ua ntu zus. Qhov ua tau zoo ntawm txoj kev ua no tsis tau muaj pov thawj, thiab kev ruaj ntseg nug ntau cov lus nug. Hauv feem ntau cov chaw kho mob, atorva yog qhov zoo dua rau rosuvastatin hauv nws qhov kev nyab xeeb.

Ntsuam Xyuas 4.2 / 5

Txij nkawm

Nqe / zoo

Sab sij huam

Lub sij hawm-kuaj xyuas los ntawm tib neeg thiab yeeb tshuaj, lub npe yooj yim thiab nco tsis cumbersome.

Ntev ntev kuv tsis tuaj yeem nkag siab vim li cas kuv tsis tuaj yeem siv Atorvastatin yooj yim hloov, cov txiaj ntsig ntawm kev thov ntseeg.

Kuv nyuam qhuav kawm paub txog cov tshuaj no, tab sis hauv kev coj ua rau kuv nws nyob ib qho ntawm txoj hauv kev ua ntej ntawm kev ua lub luag haujlwm.

Ntsuam xyuas 3.3 / 5

Txij nkawm

Nqe / zoo

Sab sij huam

Liprimar yog thawj atorvastatin ntawm tuam txhab Pfizer. Nws muaj ntau ntawm cov kev tshawb fawb uas qhia txog nws cov kev kho mob: los txo qhov kev pheej hmoo ntawm myocardial infarction, mob hlab ntsha tawg, tuag los ntawm kev mob plawv thiab kev tuag tag. Yog lawm, qhov ntau zaus ntawm cov xwm txheej no tsawg dua rau cov uas muaj kev pheej hmoo loj thaum pib - twb muaj kev mob plawv, nrog rau cov neeg muaj ntau yam kev pheej hmoo: ntshav siab, ntshav siab, ntshav qab zib, haus luam yeeb, thiab lwm yam.

Zoo li txhua yam.Kev tsis txaus siab tshwm sim thaum tsis muaj lub siab xav. Kuv tsis nyiam qhov tseeb tias kev tshaj xov xwm yog kev ua kom ruam mus rau "nthuav tawm" thiab "nthuav tawm" cov statins uas muaj qhov tsis muaj txiaj ntsig zoo thiab cov dab neeg. Statins tsis “txov” ob lub siab lossis ob lub raum, thiab tsis ua rau mob Alzheimer lossis kabmob. Statins yog ib qho ntawm cov tshuaj uas tau kawm thiab muaj kev nyab xeeb tshaj plaws nyob hauv keeb kwm tshuaj.

Txhua tus neeg uas tuaj yeem tso cai Liprimar ua tshuaj ntawm atorvastatin tuaj yeem siv Liprimar ua nws cov qauv. Yog tias tsis muaj nyiaj rau kev txais lub sijhawm ntev ntawm Liprimar, koj tuaj yeem noj cov generics, tab sis cov neeg zoo. Atoris yog ib tus no.

Ntsuam Xyuas 4.2 / 5

Txij nkawm

Nqe / zoo

Sab sij huam

Cov tshuaj qub los ntawm cov pab pawg ntawm statins (atorvastatin). Nws txo qhov LDL zoo. Nws yog ntawv pov thawj los ntawm kws kho mob raws li kev taw qhia, coj mus rau hauv tus account lub plawv mob.

Kev nce qib ntawm transaminases yog ua tau, nyob rau hauv kev sib txuas nrog qhov kev tswj ntawm ALT, AST hauv kev ruaj khov yog qhov tsim nyog. Nws raug txiav txim siab lees txais yuav cov tshuaj ntawm theem ntawm ALT, AST txog 3 qhov kev cai.

Ntsuam Xyuas 4.6 / 5

Txij nkawm

Nqe / zoo

Sab sij huam

Nrog rau qhov siv ntev, qhov feem pua ntawm cov stenosis txo qis, ntsuas tus kheej los ntawm ultrasound. Yuav luag tsis muaj kev phiv. Tus nqi nrog daim npav yog qhov tsim nyog yog tias koj nqa ib pob loj. Kuv pom zoo raws li cov atorvastatin zoo tshaj plaws.

Kuv pom zoo nws rau txhua tus neeg mob, ntawm chav kawm, yog tias nws kim - Kuv tab tom nrhiav lwm txoj hauv kev zoo sib xws.

Ntsuam Xyuas 4.6 / 5

Txij nkawm

Nqe / zoo

Sab sij huam

Nyhuv! Nrog cov plahaum muag, tom qab 3 lub hlis nws muaj peev xwm txo qis feem pua ntawm ICA stenosis, subclavian hlab ntsha los ntawm 10-20%!

Nqe, tab sis rau cov khoom lag luam zoo nws tsis yooj yim sua kom ua nrog cov txhais tau tias me me. Txhua yam paub hauv kev sib piv - nrog rosuvastatin, cov generics tseem kim tshaj tus qauv Liprimar.

Rau cov neeg koj hlub - qhov no yog yeeb tshuaj ntawm kev xaiv!

Kws Tshuaj

Hluavtaws lipid-txo cov tshuaj. Atorvastatin yog ib qho kev xaiv sib tw muaj zog ntawm HMG-CoA reductase, muaj cov enzyme tseem ceeb uas hloov 3-hydroxy-3-methylglutaryl-CoA rau mevalonate, ua ntej rau steroids, suav nrog cov roj (cholesterol).

Hauv cov neeg mob homozygous thiab heterozygous tsev neeg hypercholesterolemia, cov ntaub ntawv tsis muaj tsev neeg hypercholesterolemia thiab sib xyaw dyslipidemia, atorvastatin txo tag nrho cov roj (Ch) hauv ntshav, ntshav roj-LDL thiab apolipoprotein B (apo-B), thiab tseem ua rau cov tsis txaus ntseeg Chr-LH tsis khov nce theem ntawm HDL-C.

Atorvastatin txo qis kev ua haujlwm ntawm cov roj (cholesterol) thiab lipoproteins hauv ntshav plasma, tiv thaiv HMG-CoA reductase thiab cov roj (cholesterol) ua ke nyob rau hauv daim siab thiab nce cov hepatic LDL receptors nyob rau ntawm tes, uas ua rau muaj kev nce siab thiab catabolism ntawm LDL-C.

Atorvastatin txo qhov tsim ntawm LDL-C thiab tus lej ntawm LDL hmoov. Nws ua rau muaj suab nrov thiab tsis tu ncua nce ntxiv hauv cov dej num ntawm LDL receptors, ua ke nrog cov txiaj ntsig zoo tsim nyog hloov hauv LDL hais. Txo cov theem ntawm LDL-C hauv cov neeg mob homozygous kab mob hypercholesterolemia, tiv taus kev kho mob nrog lwm cov lipid-txo tshuaj.

Atorvastatin hauv koob tshuaj 10-80 mg txo qib ntawm cov roj (cholesterol) tag nrho los ntawm 30-46%, LDL-C los ntawm 41-61%, apo-B los ntawm 34-50% thiab TG los ntawm 14-33%. Cov kev kho mob pom tau zoo sib xws hauv cov neeg mob nrog heterozygous tsev neeg hypercholesterolemia, tsis yog tsev neeg cov ntaub ntawv ntawm hypercholesterolemia thiab hyperlipidemia sib xyaw, suav nrog hauv cov neeg mob uas tsis mob ntshav qab zib tsis yog insulin-mellitus.

Hauv cov neeg mob uas muaj tus kabmob hypertriglyceridemia, atorvastatin txo qis tag nrho cov roj, Chs-LDL, Chs-VLDL, apo-B thiab TG thiab nce qib ntawm Chs-HDL. Hauv cov neeg mob uas mob dysbetalipoproteinemia, cholesterol yuav txo qis lipoproteins ntau ntom.

Hauv cov neeg mob uas muaj hom IIa thiab IIb hyperlipoproteinemia raws li kev faib tawm Fredrickson, tus nqi nruab nrab ntawm nce HDL-C thaum kho nrog atorvastatin (10-80 mg), piv nrog thawj zaug tus nqi, yog 5.1-8.7% thiab tsis vam khom lub koob tshuaj. Muaj qhov tseem ceeb ntawm qhov txo qis hauv qhov piv: tag nrho cov roj cholesterol / Chs-HDL thiab Chs-LDL / Chs-HDL los ntawm 29-44% thiab 37-55%, feem.

Liprimar ® ntawm ib koob tshuaj 80 mg txo qhov kev pheej hmoo ntawm ischemic teeb meem thiab kev tuag ntawm 16% tom qab kawm 16-lub lis piam, thiab kev pheej hmoo rov qab pw tsev kho mob rau angina pectoris, nrog cov cim ntawm myocardial ischemia, los ntawm 26%. Hauv cov neeg mob uas muaj qib sib txawv ntawm LDL-C, Liprimar ® txo txoj kev pheej hmoo ntawm ischemic cov teeb meem thiab kev tuag (rau cov neeg mob myocardial infarction tsis muaj Q yoj thiab tsis khov, tus txiv neej thiab poj niam, cov neeg mob hnub nyoog qis dua 65 xyoos).

Kev txo qis ntshav plasma ntau ntawm LDL-C yog zoo dua nrog cov koob tshuaj ntau dua li nws qhov kev nkag siab hauv cov ntshav ntshav.

Kev ua rau txoj kev kho tau tiav 2 lub lis piam tom qab pib kho, mus txog qhov siab kawg tom qab 4 lub lis piam thiab tawm tsam mus tas lub sijhawm kho.

Kev Tiv Thaiv Kab Mob Tiv Thaiv Kab Mob

Hauv kev kawm txog Anglo-Scandinavian txog kev mob plawv ntawm lub plawv, lipid-txo ceg (ASCOT-LLA), cov nyhuv ntawm atorvastatin rau kev mob ntshav siab thiab tsis mob ntshav siab rau lub plawv, nws tau pom tias cov nyhuv ntawm txoj kev kho atorvastatin ntawm ib koob tshuaj 10 mg ntau dhau ntawm cov nyhuv ntawm cov placebo, thiab yog li ntawd tau txiav txim siab kev txiav tawm ntxov ntawm txoj kev tshawb no tom qab 3.3 xyoo hloov qhov kev cia siab 5 xyoo.

Atorvastatin txo txoj kev loj hlob ntawm cov teeb meem hauv qab no:

Teeb meem	Txoj kev pheej hmoo txo
Cov mob hlab ntsha hlwb (tuag rau mob plawv thiab mob ntshav qab zib tsis ua mob rau lub cev)	36%
Kev kho plawv thiab cov kev ua kom rov zoo tuaj	20%
Hom tshwm sim plawv plawv	29%
Mob stroke (tuag taus thiab tsis-muaj neeg tuag)	26%

Tsis muaj qhov tseem ceeb txo qis hauv qhov ntsuas ntawm txhua qhov kev tuag thiab kev tuag ntawm tus kab mob plawv, txawm hais tias muaj cov ncauj lus zoo.

Hauv kev kawm txog kev cuam tshuam ntawm atorvastatin hauv cov neeg mob uas muaj ntshav qab zib hom 2 ntshav qab zib mellitus (CARDS) ntawm kev ua rau cov neeg tuag taus thiab tsis muaj txiaj ntsig ntawm cov kab mob plawv, nws tau pom tias kev kho mob nrog atorvastatin, tsis hais tus neeg mob poj niam, hnub nyoog, lossis theem pib ntawm LDL-C, txo qhov kev pheej hmoo ntawm kev tsim cov kev mob plawv hauv qab no. :

Teeb meem	Txoj kev pheej hmoo txo
Lub ntsiab ntawm cov hlab plawv mob hnyav (tuag taus thiab tsis ua rau lub cev myocardial infarction, mob latent myocardial infarction, kev tuag vim exacerbation ntawm kev mob plawv, tsis txaus ntseeg lub plawv tsis khov, mob ntshav tawm ntawm txoj kev mob ntshav hauv lub cev, ua pob txha caj qaum hlab ntshav hlab ntshav hlab plawv, mob hlab ntshav hlab ntsha)	37%
Myocardial infarction (tuag taus thiab tsis mob feem ntau myocardial infarction, latent myocardial infarction)	42%
Mob stroke (tuag taus thiab tsis-muaj neeg tuag)	48%

Hauv kev kawm txog kev thim rov qab ntawm kev txhim kho kev mob ntshav siab nrog kev mob ntshav siab nrog kev kho ntshav siab (REVERSAL) nrog atorvastatin ntawm kev txhaj tshuaj ntawm 80 mg rau cov neeg mob uas muaj mob plawv, nws tau pom tias qhov nruab nrab txo nyob rau hauv tag nrho cov ntim ntawm atheroma (thawj cov qauv ntawm kev ua tau zoo) txij li pib ntawm kev tshawb fawb yog 0.4%.

Cov Kev Pabcuam Cholesterol Tshaj Plaws (SPARCL) pom tias atorvastatin ntawm ib koob ntawm 80 mg / hnub txo cov kev pheej hmoo ntawm kev tuag taus lossis tsis ua rau cov neeg tuag rau hauv cov neeg mob uas muaj keeb kwm ntawm mob stroke lossis hloov ischemic nres tsis muaj mob rau cov leeg ntshav yog 15% piv nrog cov placebo. Tib lub sijhawm, txoj kev pheej hmoo ntawm kev mob plawv loj thiab cov txheej txheem rov ua haujlwm tau txo qis qis dua. Kev txo qis ntawm kev pheej hmoo ntawm cov hlab plawv thaum lub sij hawm kho nrog atorvastatin tau pom hauv txhua pawg tsuas yog ib qho uas suav nrog cov neeg mob thawj lossis rov qab mob hemorrhagic mob stroke (7 hauv pawg atorvastatin tiv thaiv 2 hauv cov pawg placebo).

Hauv cov neeg mob kho nrog atorvastatin kho ntawm ib koob ntawm 80 mg, qhov tshwm sim ntawm hemorrhagic lossis ischemic stroke (265 tiv thaiv 311) lossis IHD (123 tiv thaiv 204) tsawg dua nyob rau hauv pawg tswj hwm.

Thib ob tiv thaiv kev mob plawv

Hais txog Txoj Kev Tshawb Fawb Tshiab (TNT), kev cuam tshuam ntawm atorvastatin ntawm kev txhaj tshuaj ntawm 80 mg / hnub thiab 10 mg / hnub ntawm kev pheej hmoo ntawm kev tsim mob plawv mob hauv cov neeg mob uas tau txais cov kab mob ntsig txog cov hlab ntshav txhaws tau piv rau.

Atorvastatin ntawm koob tshuaj 80 mg txo qhov kev loj hlob ntawm cov teeb meem hauv qab no:

Teeb meem	Atorvastatin 80 mg
Thawj qhov kawg
Thawj qhov kev mob plawv tseem ceeb tshaj plaws (kev mob ntshav siab rau lub plawv thiab mob ntshav qab zib tsis ua kom tuag)	8.7%
Tsis-tuag taus myocardial infarction	4.9%
Mob stroke (tuag taus thiab tsis-muaj neeg tuag)	2.3%
Thib ob endpoint
Thawj zaug pw hauv tsev kho mob rau txhaws mob plawv	2.4%
Thawj txoj hlab ntshav txhim kho kev phais los yog lwm cov txheej txheem kho cov hlab ntshav	13.4%
Thawj cov ntaub ntawv angina pectoris	10.9%

Daim ntawv tso tawm

Cov ntsiav tshuaj, coated nrog cov xim zaj duab xis txheej dawb, yog elliptical, sau nrog "10" ntawm ib sab thiab "PD 155" ntawm lwm yam, ntawm pob txha tawg muaj qhov tseem ceeb dawb.

1 tab
atorvastatin calcium	10,85 mg
uas sib haum rau cov ntsiab lus ntawm atorvastatin	10 mg

Cov zam: calcium carbonate - 33 mg, microcrystalline cellulose - 60 mg, lactose monohydrate - 32,8 mg, croscarmellose sodium - 9 mg, polysorbate 80 - 0.6 mg, hyprolose - 3 mg, magnesium stearate - 0.75 mg.

Cov kev sib xyaw ntawm cov zaj duab xis txheej: opadry dawb YS-1-7040 (hypromellose - 66.12%, polyethylene glycol - 18.9%, titanium dioxide - 13.08%, talc - 1.9%) - 4.47 mg, simethicone emulsion (simethicone - 30%, stearic emulsifier - 0.075%) , sorbic acid, dej) - 0.03 mg, candelila siv quav ciab - 0.08 mg.

10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs - hlwv (10) - pob khoom ntawm cardboard.

Ua ntej pib kev kho mob nrog Liprimar ®, ib qho yuav tsum sim ua kom tiav kev tswj hwm ntawm hypercholesterolemia los ntawm kev noj haus, kev tawm dag zog thiab kev poob phaus hauv cov neeg mob rog, nrog rau kev kho mob hauv qab.

Thaum muab tshuaj rau, cov neeg mob yuav tsum pom zoo rau kev noj zaub mov hypocholesterolemic noj, uas nws yuav tsum tau ua raws thaum lub sijhawm kho.

Cov tshuaj tau noj ntawm qhov ncauj thaum lub sijhawm thaum nruab hnub, tsis hais noj zaub mov.

Qhov ntau npaum li cas ntawm cov tshuaj sib txawv ntawm 10 mg txog 80 mg 1 lub sijhawm / hnub, xaiv cov koob tshuaj yuav tsum tau nqa tawm mus rau hauv tus account thawj cov ntsiab lus ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ntawm tus kheej. Qhov siab tshaj plaws yog 80 mg 1 zaug / hnub.

Thaum pib kho thiab / lossis thaum lub sijhawm nce ntxiv ntawm Liprimar ®, nws yog qhov yuav tsum tau soj ntsuam cov plasma lipid cov ntsiab lus txhua 2-4 lub lis piam thiab kho qhov tshuaj raws li.

Hauv thawj hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia rau feem ntau cov neeg mob, koob tshuaj Liprimar yog 10 mg 1 zaug / hnub. Cov kev kho mob nyhuv ua rau pom nyob rau hauv 2 lub lis piam thiab feem ntau nce mus txog qhov siab tsis pub dhau 4 lub lis piam. Nrog kev kho mob ntev, cov nyhuv cuam tshuam.

Nrog homozygous tsev neeg hypercholesterolemia, cov tshuaj yog tawm ntawm koob tshuaj 80 mg 1 zaug / hnub (txo qis hauv LDL-C los ntawm 18-45%).

Thaum lub siab tsis ua haujlwm, koob tshuaj Liprimar ® yuav tsum txo qis nyob rau hauv kev soj qab tas li ntawm ACT thiab ALT kev ua si.

Lub raum ua haujlwm tsis zoo cuam tshuam rau qhov kev txiav txim ntawm atorvastatin hauv ntshav ntshav lossis qhov siab ntawm qhov txo qis hauv cov ntsiab lus ntawm LDL-C thaum siv Liprimar, yog li ntawd, kev hloov tshuaj tsis tas yuav tsum tau txhaj.

Thaum siv cov tshuaj hauv cov neeg laus cov neeg mob, qhov sib txawv ntawm kev ua tau zoo thiab kev nyab xeeb piv nrog rau cov pej xeem sawv daws tsis pom, thiab kev kho tshuaj tsis tas yuav tsum tau.

Yog tias tsim nyog, kev siv sib xyaw nrog cyclosporine, koob tshuaj Liprimar ® yuav tsum tsis pub tshaj 10 mg.

Cov lus pom zoo rau kev txiav txim lub hom phiaj ntawm kev kho mob

A. Cov lus pom zoo los ntawm National NCEP Cholesterol Kev Kawm Txuj Ci, Tebchaws Asmeskas

Nrog kev tswj hwm tib lub sijhawm ntawm Liprimar thiab kev ncua kev kawm uas muaj cov khoom siv magnesium thiab aluminium hydroxides, qhov kev sib xyaw ntawm atorvastatin hauv cov ntshav poob qis txog li 35%, txawm li cas los xij, qhov kev kawm txo qis hauv qib LDL-C tsis hloov pauv.

Nrog rau kev siv tib lub sijhawm Liprimar ® tsis cuam tshuam qhov pharmacokinetics ntawm phenazone, yog li ntawd, kev cuam tshuam nrog lwm cov tshuaj metabolized los ntawm tib lub cytochrome isoenzymes tsis xav.

Nrog rau kev siv colestipol tib lub sijhawm, kev ua haujlwm ntawm atorvastatin hauv ntshav txo qis li 25%. Txawm li cas los xij, lipid-txo cov nyhuv ntawm kev sib txuam ntawm atorvastatin thiab colestipol ntau dua qhov ntawm txhua cov tshuaj ib tus zuj zus.

Nrog kev rov qab siv digoxin thiab Liprimar ntawm koob tshuaj 10 mg, qhov sib npaug ntawm digoxin hauv cov ntshav ntshav tsis hloov. Txawm li cas los xij, thaum digoxin tau siv ua ke nrog Liprimar ntawm koob tshuaj 80 mg / hnub, qhov kev txiav txim siab ntawm digoxin nce ntxiv txog 20%. Cov neeg mob uas tau txais digoxin ua ke nrog Liprimar yuav tsum muaj kev soj ntsuam hauv tsev kho mob.

Nrog rau kev siv Liprimar tib lub sij hawm ntawm 10 mg 1 zaug / hnub thiab azithromycin ntawm koob tshuaj 500 mg 1 zaug / hnub, qhov kev nqus ntawm atorvastatin hauv ntshav tsis hloov pauv.

Nrog rau kev siv Liprimar tib lub sijhawm thiab lub qhov ncauj txwv tsis pub muaj norethisterone thiab ethinyl estradiol, qhov nce ntxiv ntawm AUC ntawm norethisterone thiab ethinyl estradiol tau pom los ntawm kwv yees li 30% thiab 20%, feem. Cov nyhuv no yuav tsum tau txiav txim siab thaum xaiv qhov ncauj tawm tsam rau tus poj niam tau txais Liprimar ®.

Liprimar ® nrog kev siv tib lub sij hawm tsis muaj kev cuam tshuam loj hauv lub chaw muag tshuaj ntawm terfenadine.

Cov tsos mob ntawm kev cuam tshuam loj ntawm kev sib kis ntawm atorvastatin nrog warfarin tsis pom.

Nrog rau kev siv Liprimar tib lub sij hawm ntawm 80 mg thiab amlodipine ntawm koob tshuaj 10 mg, pharmacokinetics ntawm atorvastatin tsis hloov pauv hauv qhov sib npaug.

Lwm txoj kev kho kom zoo

Hauv kev sim tshuaj, Liprimar used tau siv ua ke nrog cov tshuaj tiv thaiv kabmob thiab estrogens, uas tau raug tshaj tawm raws li kev hloov kho, tsis muaj cov tsos mob ntawm qhov tsis txaus ntseeg hauv chav kho mob tau sau tseg. Kev kawm txog kev sib cuam tshuam nrog cov tshuaj tshwj xeeb tseem tsis tau ua.

Cev xeeb tub thiab lactation

Liprimar contra yog contraindicated rau kev siv thaum cev xeeb tub thiab thaum lactation (pub niam mis).

Cov poj niam uas muaj hnub nyoog yug me nyuam yuav tsum siv cov kev txwv kom muaj txiaj ntsig thaum lub sijhawm kho. Liprimar ® tuaj yeem kho mob rau cov poj niam uas muaj hnub nyoog yug me nyuam tsuas yog tias qhov tshwm sim ntawm cev xeeb tub muaj tsawg heev, thiab tus neeg mob tau paub txog qhov kev pheej hmoo rau tus me nyuam hauv plab thaum kho.

Kuj tsis paub meej tias atorvastatin ua rau niam mis tso. Yog tias nws yuav tsum tau siv cov tshuaj thaum lactation, pub mis niam yuav tsum tau tsum txiav kom tsis txhob muaj kev phom sij ntawm cov menyuam mos.

Siv rau lub siab ua haujlwm tsis zoo

Kev siv cov tshuaj yog contraindicated nyob rau hauv kev mob siab mob siab lossis nce siab hauv cov dej num ntawm transaminases (ntau dua 3 zaug piv nrog VGN) ntawm keeb kwm tsis paub.

Thaum lub siab tsis ua haujlwm, koob tshuaj Liprimar ® yuav tsum txo qis nyob rau hauv kev soj qab tas li ntawm ACT thiab ALT kev ua si.

Nrog kev ceev faj, cov tshuaj yuav tsum yog cov tshuaj yog tias muaj keeb kwm muaj kab mob siab.

Cov lus qhia tshwj xeeb

Ua rau daim siab

Ib yam li lwm cov lipid-txo cov tshuaj ntawm tib chav, tom qab kev kho mob Liprimar ®, qhov nruab nrab (ntau tshaj 3 zaug piv nrog VGN) nce hauv cov dej ntshiab ntawm AST thiab ALT tau sau tseg. Kev nce ntxiv hauv cov ntshav ntau ntawm hepatic transaminases (ntau dua 3 zaug piv nrog VGN) tau pom nyob hauv 0.7% ntawm cov neeg mob tau txais Liprimar ® hauv kev sim tshuaj. Kev hloov pauv ntau zaus thaum siv cov tshuaj hauv koob tshuaj 10 mg, 20 mg, 40 mg thiab 80 mg yog 0.2%, 0.2%, 0.6% thiab 2.3%, ntsig txog. Ib qho kev nce ntawm hepatic transaminase kev ua si feem ntau tsis nrog jaundice lossis lwm yam kev kuaj mob hauv lub cev. Nrog rau qhov txo qis hauv Liprimar dose, ib ntus lossis tsis ua tiav cov tshuaj, cov haujlwm ntawm hepatic transaminases rov qab mus rau nws qhov qub.Feem ntau ntawm cov neeg mob txuas ntxiv noj Liprimar ® kom txo qis yam tsis muaj kev mob tshwm sim.

Ua ntej pib, 6 lub lis piam thiab 12 lub lis piam tom qab pib noj tshuaj lossis tom qab nce qhov koob tshuaj, ntxiv rau thaum lub sijhawm tag nrho ntawm kev kho mob, nws yog ib qho tsim nyog yuav tau soj ntsuam daim siab kev ua haujlwm. Lub siab ua haujlwm tseem yuav tsum tau kuaj xyuas thaum cov kab mob kev saib xyuas lub siab tshwm sim. Yog tias muaj kev nce ntawm kev ua haujlwm ntawm hepatic transaminases, lawv cov kev ua haujlwm yuav tsum tau saib xyuas kom txog thaum nws ua haujlwm li qub. Yog tias qhov nce hauv AST lossis ALT kev ua haujlwm los ntawm ntau dua 3 zaug piv nrog VGN mob siab, nws raug nquahu kom txo qhov koob tshuaj lossis tsum tsis ua Liprimar ®.

Skeletal leeg ua

Hauv cov neeg mob tau txais Liprimar ®, myalgia tau sau tseg. Kev kuaj mob ntawm myopathy (mob leeg thiab tsis muaj zog ua ke nrog kev nce hauv CPK kev ua si los ntawm ntau dua 10 zaug piv nrog VGN) yuav tsum xav rau cov neeg mob uas mob myalgia, mob nqaij lossis tsis muaj zog thiab / lossis cim tau nce hauv CPK cov haujlwm. Kev kho Liprimar should yuav tsum tsis ua mus ntxiv thaum muaj kev hais tawm ntau hauv KFK kev ua haujlwm, thaum pom tseeb tias yog tus mob myopathy. Txoj kev pheej hmoo ntawm myopathy hauv kev kho mob nrog lwm cov tshuaj ntawm cov hauv chav kawm no tau nce nrog kev siv cyclosporine, fibrates, erythromycin, nicotinic acid hauv hypolipidemic doses (ntau dua 1 g) lossis tshuaj tua kab mob (azole derivatives). Ntau ntawm cov tshuaj no inhibit CYP3A4 isoenzyme metabolism thiab / lossis thauj tshuaj. Nws paub tias cytochrome CYP3A4 isoenzyme yog lub siab isoenzyme lub siab koom nrog biotransformation ntawm atorvastatin. Thaum sau tshuaj Liprimar ® ua ke nrog fibrates, erythromycin, immunosuppressants, tshuaj tua kab mob (azole derivatives) los yog nicotinic acid hauv hypolipidemic doses, cov txiaj ntsig uas xav tau thiab kev pheej hmoo ntawm kev kho yuav tsum tau ua tib zoo ntsuas. Cov neeg mob yuav tsum tau soj ntsuam tas li txhawm rau txhawm rau txhawm rau txhawm rau mob leeg lossis tsis muaj zog, tshwj xeeb tshaj yog thaum thawj lub hlis ntawm kev kho mob thiab thaum lub sijhawm nce ntxiv ntawm ib qho yeeb tshuaj twg. Yog tias tsim nyog, kev sib txuas ua ke yuav tsum xav txog qhov siv tau cov tshuaj no hauv kev txo qis thiab saib xyuas cov koob tshuaj. Nyob rau tej qhov xwm txheej zoo li no, kev txiav txim siab ntawm CPK cov haujlwm txhua lub sijhawm tuaj yeem pom zoo, txawm hais tias kev saib xyuas zoo li no tsis tiv thaiv kev txhim kho kev mob myopathy.

Thaum siv cov tshuaj Liprimar ®, zoo li lwm yam statins, tsis tshua muaj mob ntawm rhabdomyolysis nrog mob raum tsis ua haujlwm vim tias myoglobinuria tau piav qhia. Yog tias cov tsos mob ntawm tus mob myopathy zoo li tshwm sim lossis muaj kev pheej hmoo rau lub raum tsis ua haujlwm vim rhabdomyolysis (piv txwv, mob hnyav, mob ntshav qis, kev phais mob ntau, kev poob siab, metabolic, endocrine thiab electrolyte kev puas tsuaj thiab kev tswj tsis tau chua leeg), Liprimar ® kev kho mob yuav tsum tau txiav ib ntus lossis tag nrho rho teb.

Cov neeg mob yuav tsum tau ceeb toom tias lawv yuav tsum tau sab laj nrog kws kho mob sai sai yog tias tsis hnov qhov mob lossis cov leeg tsis muaj zog, tshwj xeeb tshaj yog tias lawv nrog mob tshwm sim lossis kub taub hau.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Tsis muaj cov ntaub ntawv hais txog cov nyhuv ntawm atorvastatin ntawm kev muaj peev xwm tsav tsheb thiab koom nrog cov xwm txheej phom sij uas xav tau kev nce siab ntawm cov xim xav tau thiab nrawm ntawm cov kev xav psychomotor.

Siv thaum cev xeeb tub thiab lactation

Liprimar yog contraindicated nyob rau hauv cev xeeb tub.

Cov poj niam uas muaj hnub nyoog yug me nyuam yuav tsum siv cov kev txwv kom muaj txiaj ntsig thaum lub sijhawm kho. Kev siv Liprimar yog contraindicated rau cov poj niam thaum lub hnub nyoog yug menyuam uas tsis siv txoj hauv kev los tiv thaiv kev pheej hmoo.

Cov teeb meem tsis tshua muaj neeg ntawm qhov tsis txaus ntseeg tom qab tau sau tseg tom qab kis tau tus me nyuam hauv tsev me nyuam tom qab HMG-CoA reductase inhibitors (statins). Cov kev tshawb fawb tsiaj tau pom tias muaj kuab lom rau kev ua me nyuam muaj nuj nqi. Liprimar yog contraindicated thaum lactation. Kuj tsis paub meej tias atorvastatin ua rau niam mis tso. Yog tias nws yog qhov tsim nyog los sau tshuaj rau lub sijhawm lactation, kev pub mis niam yuav tsum nres kom tsis txhob muaj kev phom sij ntawm cov menyuam mos.

Noj ntau dhau

Tsis muaj ib qho tshuaj tshwj xeeb rau kev kho mob ntawm kev siv tshuaj ntau dhau nrog Liprimar. Yog tias dhau ntawm kev siv tshuaj ntau dhau, kev kho mob cov tsos mob yuav tsum ua raws li qhov tsim nyog. Kev ntsuam xyuas lub siab ua haujlwm yuav tsum tau ua thiab CPK cov haujlwm yuav tsum tau saib xyuas. Txij li thaum cov tshuaj nquag khi rau cov ntshav plasma protein, hemodialysis tsis muaj txiaj ntsig.

Yeeb tshuaj sib cuam tshuam

Nrog kev coj ua ke ntawm Laprimar nrog cyclosporine, erythromycin, tshuaj tua kab mob los ntawm azole pawg thiab fibroic acid derivatives, qhov kev pheej hmoo ntawm kev tsim myopathy nce siab.

Nrog rau kev siv ua ke ntawm atorvastatin nrog cytochrome inhibitors (P450 3A4) hauv cov ntshav ntshav, cov ntsiab lus ntawm cov kev hloov pauv tsis txawv txav ntxiv.

Nrog tib lub sijhawm siv nrog inducers ntawm P450 3A4 isoenzyme, antacids, thiab cholestipol, ntshav ntau ntawm tsis hloov pauv ntawm atorvastatin txo qis. Txawm li cas los xij, ib cov lus tshaj tawm lipid-txo cov nyhuv yog sau tseg.

Thaum muab sib xyaw nrog cov tshuaj tiv thaiv hauv qhov ncauj uas muaj cov tshuaj ethinyl estradiol thiab norethindrone, lawv qhov nqus (AUC) nce 20-30%.

Ua rau daim siab

Ib yam li kev siv lwm yam tshuaj lipid-txo qis hauv cov chav kawm no, nrog kev siv tshuaj Liprimar, qhov nruab nrab nce ntxiv (ntau dua 3 zaug piv nrog VGN) ntawm kev ua haujlwm ntawm hepatic transaminases AST thiab ALT tau sau tseg. Kev nce ntxiv hauv cov ntshav dej muaj txiaj ntsig ntawm hepatic transaminases (ntau dua 3 zaug piv nrog VGN) tau pom nyob hauv 0.7% ntawm cov neeg mob tau txais Liprimar. Kev hloov pauv ntau zaus thaum siv cov tshuaj hauv koob tshuaj 10 mg, 20 mg, 40 mg thiab 80 mg yog 0.2%, 0.2%, 0.6% thiab 2.3%, ntsig txog. Ib qho kev nce ntawm hepatic transaminase kev ua si feem ntau tsis nrog jaundice lossis lwm yam kev kuaj mob hauv lub cev. Nrog rau qhov txo qis hauv Liprimar, ib ntus lossis ua tiav tsis raug tshuaj, cov haujlwm ntawm hepatic transaminases rov qab mus rau nws cov qib qub. Feem ntau ntawm cov neeg mob txuas ntxiv noj Liprimar hauv kev txo qis yam tsis muaj kev mob tshwm sim.

Ua ntej pib, 6 lub lis piam thiab 12 lub lis piam tom qab pib noj tshuaj lossis tom qab nce qhov tshuaj, nws yog ib qhov yuav tsum tau soj ntsuam daim siab kev ua haujlwm. Lub siab ua haujlwm tseem yuav tsum tau kuaj xyuas thaum cov kab mob kev saib xyuas lub siab tshwm sim. Yog tias muaj kev nce ntawm kev ua haujlwm ntawm hepatic transaminases, lawv cov kev ua haujlwm yuav tsum tau saib xyuas kom txog thaum nws ua haujlwm li qub. Yog tias qhov nce hauv AST lossis ALT kev ua haujlwm los ntawm ntau dua 3 zaug piv nrog VGN mob siab, nws raug nquahu kom txo qhov koob tshuaj lossis tsis txiav Liprimar.

Liprimar yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas haus cov dej cawv thiab / lossis muaj keeb kwm muaj kab mob siab. Lub siab ua mob siab lossis ua haujlwm tsis tu ncua los ntawm hepatic transaminases ntawm cov ntshav plasma ntawm keeb kwm tsis meej yog qhov sib kis rau kev siv Liprimar.

Ntxim rau cov leeg pob txha

Tus mob Myalgia tau sau tseg hauv cov neeg mob uas tau txais Liprimar. Kev kuaj mob ntawm tus mob myopathy yuav tsum xav nyob hauv cov neeg mob uas mob myalgia, mob nqaij los yog mob tsis muaj zog thiab / lossis cim KFK kev ua si ntau dua (ntau dua 10 zaug piv nrog VGN). Kev kho Liprimar yuav tsum tsis ua mus ntxiv thaum muaj qhov cim tseg hauv kev ua haujlwm ntawm CPK, thaum pom tias muaj tus mob myopathy pom. Txoj kev pheej hmoo ntawm myopathy thaum kho nrog lwm cov tshuaj ntawm cov hauv chav kawm no tau nce nrog kev siv zog sib xyaw ua ke ntawm CYP3A isoenzyme (piv txwv li, cyclosporine, telithromycin, clarithromycin, delavirdine, styripentol, ketoconazole, voriconazole, itraconazole, posaconazole, atavirinininavavinin darunavir), gemfibrozil lossis lwm cov fibrates, boceprevir, erythromycin, nicotinic acid hauv lipid txo cov tshuaj (ntau dua 1 g / hnub), ezetimibe, azole antifungal tus neeg sawv cev, colchicine, telaprevir, boceprevir, lossis kev sib xyaw ntawm tipranavir / ritonavir. Ntau ntawm cov tshuaj no inhibit CYP3A4 isoenzyme metabolism thiab / lossis thauj tshuaj. Nws paub tias cytochrome CYP3A4 isoenzyme yog lub siab isoenzyme lub siab koom nrog biotransformation ntawm atorvastatin. Muab tshuaj Liprimar ua ke nrog fibrates, erythromycin, immunosuppressants, antifungal tshuaj (azole derivatives) lossis nicotinic acid hauv hypolipidemic doses (ntau dua 1 g / hnub), cov txiaj ntsig uas xav tau thiab qhov pheej hmoo ntawm kev kho yuav tsum tau ua tib zoo ntsuas. Cov neeg mob yuav tsum tau soj ntsuam tas li txhawm rau txhawm rau txhawm rau txhawm rau mob leeg lossis tsis muaj zog, tshwj xeeb tshaj yog thaum thawj lub hlis ntawm kev kho mob thiab thaum lub sijhawm nce ntxiv ntawm ib qho yeeb tshuaj twg. Yog tias tsim nyog, kev sib txuas ua ke yuav tsum xav txog qhov siv tau cov tshuaj no hauv kev txo qis thiab saib xyuas cov koob tshuaj. Kev siv ua ke ntawm atorvastatin thiab fusidic acid tsis pom zoo; yog li ntawd, tshem tawm ib ntus ntawm atorvastatin raug pom zoo thaum kho nrog fusidic acid. Nyob rau tej qhov xwm txheej zoo li no, kev txiav txim siab ntawm CPK cov haujlwm txhua lub sijhawm tuaj yeem pom zoo, txawm hais tias kev saib xyuas zoo li no tsis tiv thaiv kev txhim kho kev mob myopathy.

Ua ntej kev kho mob

Liprimar yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj lwm yam cuam tshuam rau kev txhim kho ntawm rhabdomyolysis. Kev tswj ntawm kev ua haujlwm ntawm CPK yuav tsum tau nqa tawm hauv cov xwm txheej hauv qab no ua ntej pib kho txoj kev kho:

lub raum tsis ua hauj lwm zoo,
hypothyroidism
mob rau cov mob ua haujlwm hauv cov leeg mob hauv tsev neeg lossis keeb kwm tsev neeg,
twb hloov pauv cov tshuaj lom muaj hnub nyoog ntawm HMG-CoA reductase inhibitors (statins) lossis fibrates ntawm cov leeg nqaij,
keeb kwm mob siab thiab / lossis cov neeg mob uas haus cawv ntau,
nyob rau hauv cov neeg mob uas muaj hnub nyoog 70 xyoo, xav tau kev tswj hwm CPK yuav tsum raug ntsuas, muab qhov tseeb tias cov neeg mob no twb muaj lwm yam cuam tshuam rau kev txhim kho rhabdomyolysis,
cov xwm txheej uas nce ntxiv hauv plasma ntau dua ntawm atorvastatin xav tau, xws li kev sib cuam tshuam nrog lwm yam tshuaj. Hauv cov xwm txheej zoo li no, kev pheej hmoo / cov txiaj ntsig sib piv yuav tsum raug ntsuas thiab kev tshuaj xyuas tus neeg mob tus mob yuav tsum tau ua. Nyob rau hauv qhov xwm txheej ntawm qhov nce siab hauv CPK kev ua haujlwm (ntau dua 5 npaug ntau dua li VGN), kev kho mob atorvastatin yuav tsum tsis txhob pib.

Thaum siv cov tshuaj Liprimar, zoo li lwm cov tshuaj tiv thaiv HMG-CoA reductase, muaj tsawg yam mob ntawm rhabdomyolysis nrog mob raum tsis ua haujlwm vim cov mob myoglobinuria tau piav qhia. Ib qho kev pheej hmoo txaus rau rhabdomyolysis yuav yog yav dhau los ua rau lub raum khiav tsis zoo. Cov neeg mob zoo li no yuav tsum tau txais kev saib xyuas ntau dua ntawm lub xeev ntawm cov leeg nqaij. Yog tias cov tsos mob ntawm tus mob myopathy tshwm sim lossis muaj kev pheej hmoo rau kev tsim kho lub raum tsis ua haujlwm vim qhov mob rhabdomyolysis (piv txwv, mob hnyav, mob ntshav qis, kev phais mob ntau, kev raug mob, metabolic, endocrine thiab dej-cuam tshuam kev puas tsuaj, kev tswj tsis tau tus mob), Liprimar yuav tsum tau txiav tawm ib ntus lossis lossis kiag li lawm os.

Kev tiv thaiv mob txhaws hnyav los ntawm Txo Cov Hluav Taws Xob Txo

Hauv qhov kev tshuaj ntsuam yav dhau los ntawm tus mob stroke subtypes nyob rau hauv cov neeg mob uas tsis muaj mob hlab ntsha hauv lub cev, tsis ntev los no muaj mob stroke lossis hloov ischemic nres, ntawm thawj theem uas tau txais atorvastatin ntawm koob ntawm 80 mg, qhov muaj ntau dua hemorrhagic mob stroke tau sau piv nrog cov neeg mob tau txais cov placebo. Ib qho kev pheej hmoo siab ntxiv yog tshwj xeeb tshaj yog pom hauv cov neeg mob uas muaj keeb kwm mob ntshav qab zib los yog lacunar infarction thaum pib ntawm txoj kev tshawb no. Hauv pawg no cov neeg mob, cov txiaj ntsig / kev pheej hmoo sib piv thaum noj atorvastatin hauv ib koob ntawm 80 mg tsis tau txhais tau zoo, hauv qhov no, ua ntej pib txoj kev kho mob, kev pheej hmoo ntawm kev mob hemorrhagic mob stroke hauv cov neeg mob no yuav tsum tau ua tib zoo ntsuas.

Tom qab kev txheeb xyuas tshwj xeeb ntawm kev tshawb fawb soj ntsuam koom nrog 4731 cov neeg mob uas tsis muaj mob hlab ntsha hauv lub cev uas muaj mob stroke lossis hloov ischemic nres (TIA) tsis pub dhau 6 lub hlis dhau los uas tau raug tshuaj atorvastatin 80 mg / hnub, muaj ntau dua qhov mob hemorrhagic mob stroke ntawm atorvastatin pawg ntawm 80 mg tau pom tawm piv nrog cov pab pawg placebo (55 hauv pawg atorvastatin tiv thaiv 33 hauv cov pawg placebo). Cov neeg mob hemorrhagic mob stroke thaum lub sij hawm suav nrog hauv txoj kev tshawb fawb tau muaj kev pheej hmoo siab ntxiv rau kev mob hlab ntsha tawg (7 hauv pawg atorvastatin tiv thaiv 2 hauv cov pawg placebo). Txawm li cas los xij, cov neeg mob uas tau txais atorvastatin 80 mg / hnub muaj tsawg dua qhov mob stroke ntawm txhua yam (265 piv rau 311) thiab tsawg dua kev mob plawv (123 piv rau 204).

Mob ntshav qab zib mellitus

Qee cov ntaub ntawv paub tseeb tias HMG-CoA reductase inhibitors (statins), raws li chav kawm, tuaj yeem ua rau nce ntshav plasma glucose concentration, thiab hauv qee cov neeg mob uas muaj kev pheej hmoo loj los ntawm ntshav qab zib mellitus, ib lub xeev ntawm hyperglycemia tuaj yeem txhim kho uas yuav tsum tau kho raws li nyob rau hauv ntshav qab zib mellitus. Txawm li cas los xij, qhov kev pheej hmoo no tsis dhau qhov txiaj ntsig ntawm kev kho mob nrog HMG-CoA reductase inhibitors (statins) hais txog kev mob vascular, yog li no tsis tuaj yeem yog lub laj thawj ntawm kev tshem tawm txoj kev kho. Cov neeg mob koom nrog cov pab pawg muaj kev pheej hmoo (ceev ceev cov ntshav qabzib ntau los ntawm 5.6 txog 6.9 mmol / l, BMI> 30 kg / m, nce ntshav triglycerides, ntshav tawm ntshav) yuav tsum nyob hauv kev saib xyuas mob, suav nrog kev saib xyuas ntshav biochemical tsis dhau, raws li cov lus pom hauv zos.

Cov mob ntsws interstitial

Thaum kho nrog qee qhov HMG-CoA reductase inhibitors (statins), tshwj xeeb tshaj yog nyob rau cov kev kho mob mus ntev, cov neeg mob cais tawm ntawm tus mob ntsws interstitial tau raug tshaj tawm. Ua pa siav luv, hnoos tsis txaus, thiab ua kom tsis muaj mob dabtsi ntxiv (nkees, poob ceeb thawj, thiab kub ib ce) yuav tshwm sim. Yog tias tus neeg mob xav tias mob ntsws interstitial mob ntsws, kev kho atorvastatin yuav tsum tsis ua mus ntxiv.

Endocrine muaj nuj nqi

Thaum siv cov tshuaj tiv thaiv kab mob HMG-CoA reductase (statins), suav nrog atorvastatin, muaj cov mob ntawm glycosylated hemoglobin (HbA1) thiab yoo plasma ntshav qab zib concentration. Txawm li cas los xij, kev pheej hmoo ntawm hyperglycemia yog qis dua li kev paub txog kev txo qis hauv kev pheej hmoo ntawm kev mob vascular thaum noj HMG-CoA reductase inhibitors (statins).

Muaj feem xyuam rau kev muaj peev xwm ntawm kev tsav tsheb

Tsis muaj cov ntaub ntawv hais txog cov nyhuv ntawm Liprimar ntawm kev muaj peev xwm tsav tsheb thiab koom nrog cov haujlwm uas muaj kev phom sij uas xav tau kev nce siab ntawm cov xim xav tau thiab nrawm ntawm cov kev xav psychomotor. Txawm li cas los xij, vim tias muaj peev xwm ntawm kiv taub hau, ceev faj yuav tsum tau siv rau hauv cov haujlwm no

Cia rau cov neeg mob

Khaws rau hauv qhov chaw qhuav thiab tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam, ntawm qhov kub tsis tshaj 25 ° C. Txee lub neej 3 xyoos.Tom qab lub sijhawm no, kev siv cov tshuaj yog txwv.

Tus nqi nruab nrab ntawm 30 ntsiav tshuaj ntawm Liprimar 20 mg nyob rau hauv cov khw muag tshuaj hauv Moscow yog 420-460 rubles.

Liprimar analogues rau kev kho cov nyhuv yog tshuaj: