Glimepiride siv tshuaj los txo cov ntshav qab zib hauv ntshav qab zib

Glimepiride (hauv Latin qhia - Glimepiride) - Qhov no yog ib hom tshuaj tsis zoo li niaj hnub no. Ntawm tag nrho cov tshuaj tiv thaiv kab mob uas sawv cev rau chav kawm ntawm sulfonylurea tshuaj, qhov no yog qhov tshuaj yooj yim heev. Thaum cov tshuaj ua ntej pom nyob hauv cov khw muag tshuaj, lawv yog ib hom tshuaj uas nrov tshaj plaws. Tab sis tom qab nrhiav tau ntawm ib qho kev kawm tshiab ntawm cov tshuaj (incretins), lawv tau pib undeservedly tsis nco qab nws.

Cov tshuaj kuj tseem muaj cov neeg ua haujlwm ntxiv: ntxiv cov neeg mob ntawm cov nqaij mos ua rau cov insulin endogenous, txo cov khoom ntawm cov piam thaj hauv siab, tiv thaiv cov ntshav txhaws, thiab txo cov ntshav dawb.

Dosage daim ntawv

Cov chaw tsim tshuaj paus hauv tsev PHARMSTANDART ua Glimepiride ua 4 tshuaj ntsiav tshuaj:

Lub teeb liab - 1 mg,
Lub teeb ntsuab Hawj txawm - 2 mg,
Lub teeb daj - 3 mg,
Lub teeb xiav xim - 4 mg txhua.

Cov kaus poom ntim rau hauv cov ntawv ci txhuas ntawm 10 pcs., Cov phiaj tso rau hauv ntawv ntim. Khaws cov tshuaj rau hauv nws lub thawv qub ntawm chav sov tsis pub dhau 3 xyoos. Rau Glimepiride, tus nqi hauv khw muag tshuaj online yog los ntawm 153 rubles. mus txog 355 RUB. nyob ntawm ntau npaum li cas. Hom kev faib tawm yog tshuaj noj.

Glimepiride - analogues thiab cov lus ua

Cov tshuaj kho mob thaum xub thawj, thawj zaug, feem ntau kawm, yog Amaril los ntawm lub tuam txhab Sanofi Aventis. Tag nrho lwm yam tshuaj, suav nrog glimepiride, yog cov tshuaj analogues, cov tuam txhab kws tsim khoom lag luam ua rau lawv raws li tsab cai muaj. Ntawm cov nto moo tshaj plaws:

Glimepiride (Russia),
Diamerid (Russia),
Diapirid (Ukraine),
Glimepirid Teva (Croatia),
Glemaz (Argentina),
Glianov (Jordan),
Glibetik (Poland),
Amaril M (Kauslim Teb),
Glairi (Is Nrias teb).

Kev Sib xyaw ntawm cov tshuaj Glimepiride

Glimepiride yog ib qho tshuaj tiv thaiv kab mob hauv lub qhov ncauj nrog hypoglycemic tej zaum. Cov tshuaj yog zwm rau pab pawg ntawm sulfonamides, derivatives ntawm urea.

Qhov pib ua haujlwm tseem ceeb ntawm cov tshuaj yog glimepiride. Hauv ib ntsiav tshuaj, nws qhov hnyav yog 1 txog 4 mg. Cov tshuaj ua kom muaj zog yog ntxiv nrog cov khoom siv pabcuam: sodium starch, povidone, polysorbate, microcrystalline cellulose, lactose, magnesium stearate, indigo txhuas kua roj vanish.

Kws Tshuaj

Glimepiride yog ib qho tshuaj tiv thaiv kab mob los ntawm sulfonylurea pawg uas nquag thaum noj ntawm qhov ncauj. Nws yog tsim los tswj hom mob ntshav qab zib hom 2. Cov txheej txheem ntawm kev ua ntawm cov tshuaj yog raws li kev tsa ntawm of-hlwb lub luag haujlwm rau kev tsim cov tshuaj insulin endogenous. Cov tshuaj khi rau cov membrane protein ntawm cov hlwb ua kom sai.

Zoo li txhua yam tshuaj nyob hauv pab pawg no, cov tshuaj tsub kom lub siab mob ntawm cov nqaij ua rau muaj cov kua nplaum tawm. Nws muaj tshuaj noj thiab siv ua txiaj ntsig ntxiv. Kev tsim tawm cov tshuaj insulin nyob rau hauv kev cuam tshuam ntawm cov tshuaj tshwm sim vim kev txhim kho nkag mus rau cov calcium calcium: kev nce ntawm kev nkag mus ntawm calcium tuaj yeem txhawb kev tso tawm ntawm insulin.

Ntawm cov cuam tshuam ntxiv, qhov txo qis ntawm qhov tsis kam ntawm cov cell mus rau qhov kev ua tshuaj thiab qhov kev txo qis ntawm nws qhov kev siv hauv lub siab tuaj yeem sau tseg. Hauv cov leeg nqaij thiab lub cev rog, cov piam thaj tau hlawv nrog kev pab los ntawm thauj cov protein, cov haujlwm uas nce ntxiv tom qab noj cov tshuaj.

Cov Tshuaj Pharmacokinetics

Lub bioavailability ntawm glimepiride yog 100%. Qhov sib xyaw kom tsawg ntawm cov as-ham qeeb qeeb dua kev nqus me ntsis. Qhov ntshav siab tshaj plaws cov ntsiab lus tau pom 2.5 teev tom qab cov tshuaj tau txais nyob rau hauv cov hnyuv. Kev faib tawm ntawm cov tshuaj yog tsawg (8.8 L), nws khi rau cov kab mob protein ntau li ntau tau (99%), kev tshem tawm cov tshuaj yog 48 ml / min.

Nrog kev rov qab noj tshuaj dua, qhov nruab nrab ib nrab-lub neej yog 5-8 teev. Nrog rau qhov nce ntxiv hauv cov tshuaj kho mob, lub sijhawm no nce. Metabolites raug tshem tawm ib txwm muaj: 58% ntawm ib koob tshuaj uas muaj lub npe hu ua radioot isotope nyob hauv cov zis thiab 35% hauv cov quav. Ib nrab-lub neej ntawm cov khoom lwj yog 3-6 teev.

Tsis muaj qhov sib txawv hauv cov pharmacokinetics ntawm glimepiride hauv cov ntshav qab zib ntawm cov tub ntxhais hluas lossis cov hnub nyoog tiav, poj niam lossis txiv neej. Hauv cov neeg mob ntshav qab zib nrog kev tshem tawm creatinine tsawg, tsis muaj kev phom sij ntawm kev txuam nrog tshuaj. Cov teeb meem pharmacokinetic nyob rau hauv 5 cov neeg mob tom qab cholecystectomy zoo ib yam li cov neeg muaj ntshav qab zib noj qab haus huv hauv qhov no.

Hauv 26 cov tub ntxhais hluas hnub nyoog 12-17 xyoo, nrog rau 4 tus menyuam muaj hnub nyoog 10-12 xyoo, cov neeg mob ntshav qab zib hom 2, ib koob tshuaj tsawg kawg (1 mg) ntawm cov tshuaj pom tshwm sim zoo ib yam li cov neeg laus.

Leej twg tsis pom muaj glimepiride

Cov tshuaj tsis haum rau cov neeg mob ntshav qab zib nrog hom 1 yam mob, lawv tsis yog siv rau cov ketoacidosis uas mob ntshav qab zib, tsis nco qab thiab precoma, zoo li yog rau mob raum thiab mob siab rau lub siab.

Zoo li ib yam tshuaj twg, glimepiride tsis raug siv rau cov neeg mob ntshav qab zib nrog lub siab rhiab rau cov khoom xyaw ntawm cov mis, thiab zoo li lwm yam tshuaj sulfonylamide.

Glimepiride yog sib kis hauv kev xeeb tub thiab lactation.

Yuav siv li cas Glimepiride kom raug

Txhawm rau kom 100% glycemic tswj, kev siv tshuaj kho mob tsis txaus.

Cov qauv npaj qhia txog cov leeg mob hauv cov ntshav qab zib ntawm yam thib 2 ntawm lub teeb thiab nruab nrab hauv daim ntawv yuav yog cov hauv qab no:

Tawm dag zog - 2-3 p. / Lub limtiam,,
Kev taug kev nquag - 3 p ./ Lub Limtiam,
Ua luam dej, caij tsheb kauj vab, ntaus pob tesniv lossis seev cev,
Taug kev ntaiv, taug kev ntsiag to - txhua hnub.

Yog tias qhov kev nyuaj no tsis haum, koj tuaj yeem ua kev tawm dag zog txhua txhua hnub. Hauv qhov chaw zaum, mob ntshav qab zib tuaj yeem yog lub sijhawm so tsis pub ntev tshaj 30 feeb.

Cov tshuaj zoo tshaj plaws yog xaiv los ntawm tus kws kho mob, coj mus rau hauv tus account theem ntawm tus kab mob, concomitant pathologies, cov xwm txheej dav dav, hnub nyoog ntawm tus neeg mob, nws lub cev cov tshuaj tiv thaiv tshuaj.

Glimepiride cov lus qhia rau kev pom zoo pom zoo siv 1 mg / hnub. (ntawm ib tug pib koob tshuaj)Cov. Nrog li ntawm 1-2 lub lis piam, thaum nws tseem muaj peev xwm los soj ntsuam qhov txiaj ntsig, nws tuaj yeem yog titrated yog tias kev kho yav dhau los tsis zoo txaus. Cov cai ntau dua li 4 mg / hnub. thov tshwj xeeb. Qhov ntau npaum li cas ntawm kev siv tshuaj yog txog li 6 mg / hnub.

Yog tias qhov siab tshaj plaws ntawm cov tshuaj metformin tsis muab 100% glycemic tswj, Glimepiride tuaj yeem coj los ua cov kev txhawb nqa nyob rau tib lub sijhawm, nws zoo kawg nkaus ua ke nrog cov tshuaj no, txawm tias cov tshuaj sib xyaw nrog cov ob yam tshuaj no tso tawm. Cov kev kho mob zoo sib xws pib nrog qhov txhaj tshuaj tsawg kawg ntawm glimepiride (1 g), kev soj ntsuam txhua hnub ntawm cov ntsuas glucometer yuav pab kho cov kev cai. Txhua yam hloov pauv ntawm lub algorithm tsuas yog ua los ntawm kev saib xyuas mob nkeeg xwb.

Tej zaum muaj kev sib xyaw ua ke ntawm glimepiride thiab nrog kev npaj tshuaj insulinCov. Qhov ntau npaum ntawm cov ntsiav tshuaj, qhov no, yuav tsum yog thawj zaug tsawg. Raws li cov txiaj ntsig ntawm kev ntsuam xyuas, txhua ob lub lim tiam ib qho tshuaj ntawm cov tshuaj tuaj yeem hloov kho.

Feem ntau, kev noj cov tshuaj yog ib leeg. Los sib xyaw ua ke nrog cov khoom noj tshais lossis cov khoom noj ua raws nws, yog tias noj tshais hauv qab zib yog qhov cim.

Nws yog qhov zoo tshaj rau noj cov ntsiav tshuaj ob peb feeb ua ntej noj mov, raws li nws yuav siv sij hawm los nqis tes ua. Yog tias koj tsis nco qab lub sijhawm noj Glimepiride, cov tshuaj yuav tsum noj thaum thawj zaug, tsis tas hloov cov tshuaj ntau dua.

Yog tias qhov qis tshaj plaws ntawm glimepiride ua rau cov tsos mob ntawm kev mob ntshav qab zib, cov tshuaj tau raug muab tso tseg, vim tias nws txaus rau tus neeg mob los tswj nws cov piam thaj nrog kev noj zaub mov kom zoo, kev xav zoo, ua raws li kev pw tsaug zog thiab so kom txaus, ua si lub cev.

Thaum ua tiav kev tswj hwm ntshav qab zib tau tiav, cov tshuaj tiv thaiv hormone yuav poob qis, uas txhais tau tias dhau sijhawm, yuav tsum tau noj tshuaj tsawg dua. Nws kuj tseem yuav tsum tau hloov kho qhov koob tshuaj nrog poob phaus sai sai, hloov qhov xwm txheej ntawm lub cev dhau los, muaj kev ntxhov siab ntau ntxiv thiab lwm yam uas ua rau muaj teeb meem glycemic.

Muaj peev xwm ntawm hloov ntawm lwm cov tshuaj tiv thaiv kab mob rau glimepiride

Thaum hloov los ntawm lwm txoj kev kho mob rau hom ntshav qab zib hom 2 nrog rau tus neeg sawv cev ntawm lub qhov ncauj, ib nrab-lub neej ntawm cov tshuaj ua ntej tau raug coj los siv. Yog tias cov tshuaj muaj lub sijhawm no ntev dhau los (xws li chlorpropamide), ncua sijhawm ntau hnub yuav tsum tau tswj xyuas ua ntej hloov mus rau glimepiride. Qhov no yuav txo qhov pheej hmoo ntawm kev txhim kho hypoglycemia vim muaj txiaj ntsig ntxiv ntawm 2 tus neeg sawv cev. Thaum hloov cov tshuaj, cov tshuaj pib noj yog pom zoo ntawm tsawg kawg 1 mg / hnub. Txoj kev ua tiav rau cov nyiaj haujlwm zoo sib xws.

Glimepiride insulin hloov rau cov neeg mob ntshav qab zib nrog hom 2 yog ua rau muaj mob hnyav thiab nyob hauv kev saib xyuas tas mus li.

Sab sij huam

Rau glimepiride, nrog rau lwm cov tshuaj sulfa, cov pov thawj ruaj khov ntawm lawv cov hauj lwm zoo tau khaws cia. Cov kev tshawb fawb soj ntsuam kuj tau tshuaj xyuas lawv qhov kev nyab xeeb. Raws li cov lus pom zoo hauv WHO, qhov kev pheej hmoo ntawm kev tsim kho cov pliaj plhu tsis raug txheeb xyuas los ntawm kev ntsuas hauv qab no:

Ntau zaus ≥ 0.1,
Feem ntau: txij li 0.1 txog 0.01,
Caw: ntawm 0.01 txog 0.001,
Tsis tshua muaj: ntawm 0.001 txog 0.0001,
Tsis tshua muaj neeg Pab nrog overdose

Qhov phom sij tseem ceeb ntawm kev siv tshuaj ntau dhau ntawm Glimepiride yog hypoglycemia ntev txog 72 teev, tom qab ib txwm ua haujlwm, rov huam mob tuaj yeem ua tau. Thawj cov tsos mob ntawm kev haus ntau dhau yuav tshwm sim tsuas yog ib hnub tom qab kev nqus ntawm cov tshuaj. Nrog rau cov tsos mob zoo li no (dyspeptic cuam tshuam, mob hauv siab), tus neeg mob xav tau kev soj ntsuam hauv lub tsev kho mob. Nrog hypoglycemia, mob hlab ntsha hlwb kuj tseem muaj peev xwm: tsis pom kev tsis pom kev thiab kev sib koom tes, tes tshee tshee, ntxhov siab, isomnia, mob leeg, ua pa tsis nco qab.

Kev pabcuam thawj zaug thaum noj ntau dua yog kev tiv thaiv kev nqus ntawm kev siv tshuaj ntau dhau los ntawm kev ntxuav lub plab. Koj yuav tsum ua rau lub gag reflex nyob rau hauv txhua txoj kev, tom qab ntawd haus cov tshuab hluav ncaig lossis lwm qhov adsorbent thiab qee qhov laxative (piv txwv li, sodium sulfate). Nyob rau tib lub sijhawm, lub tsheb thauj neeg mob yuav tsum raug hu kom mob sai sai.

Tus neeg raug tsim txom yuav tau txhaj tshuaj pleev xim rau qabzib: ua ntej, 50 ml ntawm 50% tov, tom qab ntawd - 10%. Raws li feem ntau tau, koj yuav tsum txheeb xyuas theem ntawm cov piam thaj hauv ntshav. Ntxiv nrog rau kev kho tshwj xeeb, tsos mob kuj tau siv.

Yog tias tus me nyuam yaus noj glimepiride, qhov ntau dua ntawm cov piam thaj yuav raug xaiv los ua tus neeg mob hypoglycemia. Cov theem ntawm kev pheej hmoo yog soj ntsuam tsis tu ncua nrog glucometer.

Glimepiride thaum cev xeeb tub

Kev hloov pauv los ntawm cov qauv hauv cov ntshav sib xyaw thaum lub sijhawm cev xeeb tub tuaj yeem ua rau lub cev tsis xws luag lossis ua rau lub neej puas, thiab glycemic tsis suav nrog qhov no tsis muaj qhov tshwj xeeb. Txhawm rau txo teratogenic qhov txaus ntshai, tus poj niam yuav tsum tau saib xyuas nws cov ntawv glycemic tsis tu ncua.

Yog tias cev xeeb tub - mob ntshav qab zib uas muaj hom mob 2, nws yog pauv mus ib ntus rau insulin. Cov poj niam twb nyob rau theem kev npaj ntawm ib tus menyuam yuav tsum ceeb toom lawv tus kws tshuaj endocrinologist txog kev hloov pauv tom ntej kom kho txoj kev kho mob.

Tsis muaj cov ntaub ntawv hais txog cov kev cuam tshuam rau tib neeg lub plab ntawm glimepiride. Yog tias peb tsom mus rau cov kev tshwm sim los ntawm kev kawm txog cov tsiaj cev xeeb tub, cov tshuaj muaj tshuaj lom deev deev cuam tshuam rau cov nyhuv hypoglycemic ntawm glimepiride.

Nws tsis yog tsim cov tshuaj nkag mus rau leej niam cov kua mis, tab sis cov tshuaj tau nkag mus rau leej niam cov kua mis ntawm cov nas, yog li cov ntsiav tshuaj tseem raug muab tso tseg thaum lactation. Txij li lwm cov tshuaj ntawm sulfonylomide series kis mus rau hauv niam mis, qhov txaus ntshai ntawm cov ntshav qog ntshav hauv menyuam yaus yog qhov tshwm sim heev.

Tsis muaj ntaub ntawv qhia txog kev siv cov tshuaj rau cov neeg mob ntshav qab zib uas muaj hnub nyoog 8 xyoo rov hauv. Rau cov laus dua (txog 17 xyoo), muaj qee qhov kev pom zoo rau kev siv tshuaj raws li kev kho mob monotherapy. Cov ntaub ntawv tshaj tawm tsis txaus rau kev siv ntau dua ntawm cov tshuaj los ntawm pawg kab mob ntshav qab zib no, yog li ntawd

Cov yam ntxwv ntawm Kev Kho Mob Glimepiride

Lawv noj tshuaj li ob peb feeb ua ntej noj mov kom cov tshuaj nqus thiab pib ua haujlwm. Nrog cov nyiaj them tsis txaus rau lub peev xwm ntawm cov tshuaj nrog carbohydrates, nws tuaj yeem ua rau mob hypoglycemic. Kev tawm tsam tuaj yeem lees paub los ntawm kev sib koom ua ke ntawm cov tsos mob hauv qab no: mob taub hau, hma tsis qab los noj mov, dyspeptic cuam tshuam, isomnia, rov qab txawv txawv, tshwm sim ntawm kev tawm tsam, tiv thaiv kev tawm tsam, nce kev ntxhov siab, cuam tshuam, tsis pom kev thiab tsis hais lus, tsis meej pem nco qab, ploj ntawm rhiab thiab tswj, ceas hlwb tawg, tsaus muag , precom thiab coma. Adrenergic counterregulation tshwm sim los ntawm kev tawm hws ntau ntau, ntub dej ntawm lub duav, kev ntxhov siab nce ntxiv, lub plawv ntxhov siab, lub siab ntswj, mob plawv.

Kev paub txog kev kho cov neeg mob ntshav qab zib nrog cov tshuaj tiv thaiv ntawm sulfonylomide series qhia tau hais tias, txawm hais tias qhov ntsuas pom tseeb ntawm kev ntsuas los nres nres, muaj kev pheej hmoo ntawm nws tshwm sim dua. Cov mob ntshav qab zib ntshav ntau thiab lub caij nyoog ntau, uas ib txwm ua lub cev tsis muaj qab zib, yuav muaj kev kho mob sai sai, suav nrog hauv cov chaw nyob ruaj ruajCov. Cov xwm txheej hauv qab no ua rau muaj kev pheej hmoo hypoglycemic:

Tsis mloog cov lus qhia khomob, ua tsis taus koom tes,
Kev tshaib kev nqhis, kev noj zaub mov tsis poob, noj tsis txaus vim lub neej txom nyem,
Ua tsis tau raws cov ntsiab lus ntawm cov khoom noj muaj roj tsawg,
Tsis muaj qhov sib npaug ntawm cov leeg mob thiab cov khoom noj ua kom rog.
Cawv kev tsim txom, tshwj xeeb nrog kev noj zaub mov tsis zoo,
Cov hlwv thiab hepatic tsis ua hauj lwm zoo,
Glimepiride noj overdose
Decompensated endocrine pathologies uas cuam tshuam rau cov txheej txheem metabolic (pituitary lossis adrenal tsis txaus, lub qog ua haujlwm tsis txaus),
Concurrent siv lwm yam tshuaj.

Nrog txoj kev kho tshuaj, yuav tsum tau saib xyuas tas li ntawm glycemia. Txhawm rau zam kom tsis txhob cuam tshuam, nws yog qhov yuav tsum tau ua ntu zus mus rau lwm qhov kev kuaj:

Kev kuaj xyuas glycated hemoglobin - 1 zaug / 3-4 hlis,
Kev sab laj ntawm kws kho mob ntsej muag, kws kho qhov muag, kws kho plawv, kws kho paj hlwb - yog tias tsim nyog,
Microalbuminuria - 2 zaug / xyoo,
Kev ntsuam xyuas ntawm lipid profile + BH - 1 sijhawm / xyoo,
Kev soj ntsuam ntawm ob txhais ceg - 1 zaug / 3 hlis,
HELL - 1 zaug / hli,
ECG - 1 zaug / xyoo,
Kev tshuaj ntsuam dav dav - 1 zaug / xyoo.

Nws yog ib qho tseem ceeb rau kev saib xyuas lub sijhawm ua haujlwm ntawm lub siab thiab cov ntshav sib xyaw ua ke, tshwj xeeb piv ntawm cov ntshav platelets thiab leukocytes.

Yog tias lub cev muaj kev ntxhov siab hnyav (raug mob, kub hnyiab, phais, mob hnyav), hloov cov ntsiav tshuaj ib ntus nrog insulin yog ua tau.

Tsis muaj kev paub dhau los ntawm kev siv cov tshuaj rau kev kho mob ntshav qab zib nrog mob hepatic pathologies, zoo li cov neeg mob hemodialysis. Hauv lub raum lossis mob rau lub cev tsis muaj peev xwm, qhov ntshav qab zib tau pauv mus rau insulin.

Glimepiride muaj lactose. Yog hais tias tus mob ntshav qab zib tau kev tshuaj ntsuam genetic galactose intolerance, lactase deficiency, malabsorption ntawm galactose-qabzib, nws tau txais kev hloov kho.

Cov nyhuv ntawm glimepiride ntawm lub peev xwm tswj hwm cov txheej txheem nyuaj

Cov kev kawm tshwj xeeb ntawm glimepiride txog kev muaj peev xwm tsav tsheb los yog kev ua haujlwm hauv kev tsim khoom hauv thaj chaw muaj kev pheej hmoo siab tseem tsis tau ua. Tab sis, vim tias cov tshuaj muaj cov kev mob tshwm sim nyob rau hauv daim ntawv ntawm hypoglycemia, muaj kev pheej hmoo ntawm txo qis ntawm qhov ceev ntawm cov tshuaj tiv thaiv thiab kev mloog zoo vim yog lub zeem muag tsis pom thiab lwm cov tsos mob hypoglycemic.

Thaum muab tshuaj rau noj, cov ntshav qab zib yuav tsum tau ceeb toom ntawm kev phom sij ntawm kev muaj txim loj thaum tswj cov txheej txheem nyuajCov. Qhov no muaj tseeb tshwj xeeb tshaj yog rau cov neeg uas feem ntau muaj qhov teeb meem ntshav qab zib, nrog rau cov neeg uas tsis muaj peev xwm paub txog cov tsos mob ntawm qhov teeb meem tab tom yuav tuaj.

Cov txiaj ntsig ntawm kev sib txuam nrog lwm cov tshuaj

Cov tshuaj siv mus ib txhuv tuaj yeem ua rau muaj ntshav qab zib nce ntxiv hypoglycemic muaj peev xwm ntawm glimepiride thiab inhibit nws lub zog. Qee cov tshuaj tsis nyob nruab nrab thaum siv ua ke. Tsuas yog tus kws kho mob tshwj xeeb muaj peev xwm muab qhov kev ntsuam xyuas tseeb ntawm kev sib raug zoo, yog li ntawd, thaum kos duab kev kho mob, nws yog qhov yuav tsum ceeb toom rau tus kws kho mob endocrinologist txog txhua yam tshuaj uas tus kab mob ntshav qab zib twb siv los kho cov kab mob concomitant.

Ntxiv dag zog rau cov nyhuv hypoglycemic ntawm Glimepiride provokes kev siv tib lub sijhawm phenylbutazone, azapropazone thiab oxyphenbutazone, insulin thiab tshuaj tiv thaiv kab mob hypoglycemic, lub caij nyoog-cov nyhuv sulfanilamides, metformin, tetracyclines, MAO inhibitors, salicylic aminocyclinolefonolonon , miconazole, fenfluramine, disopyramide, pentoxifylline, fibrates, tritocvalian, ACE inhibitors, fluconazole , Fluoxetine, allopurinol, simpatolitikov, cyclo, Trojan thiab phosphamide.

Kev txwv tsis pub rau hypoglycemic muaj peev xwm ntawm glimepiride yog ua tau nrog kev ua ke nrog kev kho mob nrog estrogens, saluretics, diuretics, glucocorticoids, cov thyroid stimulants, phenothiazine derivatives, adrenaline, chlorpromazine, sympathomimetics, nicotinic acid (tshwj xeeb tshaj yog siv ntau npaum li cas), laxatives (nrog rau siv ntev) , glucagon, barbiturates, rifampicin, acetosolamide.

Qhov tshwm sim tsis tau zoo yog muab los ntawm txoj kev kho kom ruaj khov nrog β-blockers, clonidine thiab reserpine, nrog rau kev haus dej cawv.

Glimepiride muaj peev xwm txo qis lossis ua kom muaj txiaj ntsig rau lub cev ntawm coumarin derivatives.

Glimepiride Xyuas

Raws li cov kws kho mob thiab cov neeg mob, glimepiride yog cov tshuaj siv zoo heev. Nws txoj kev nyab xeeb yog muab rau hauv koob tshuaj me me, nws tseem muaj ntau qhov ntxiv uas tsis tuaj yeem tab sis zoo siab. Tab sis, zoo li txhua yam tshuaj tiv thaiv kab mob, Amaril analogue siv tau yog tias tus mob ntshav qab zib nws tus kheej pab nws.

Olga Grigoryevna, Cheeb Tsam Moscow. Kuv haus ib ntsiav tshuaj ntawm Glimepiride (2 mg) ua ntej noj tshais, thiab tom qab noj mov - tseem yog Metforminum ntev thaum sawv ntxov thiab yav tsaus ntuj txog 1000 mg. Yog tias kuv tsis ua txhaum kev noj zaub mov, ces tshuaj muaj qab zib. Kuv tsis paub tias nws cov txiaj ntsig zoo dua li cas, tab sis, nyob rau hnub so, thaum nws nyuaj rau zam kev noj mov thiab noj mov dhau, Kuv haus 3 mg ntawm Glimepiride. Kuv tau muab tshuaj rau ntawm polyclinic raws li kev txo qis tshuaj, yog vim li cas txhua yam zoo rau kuv.
Andrey Vitalievich, Yekaterinburg. Txog li 3 xyoos Kuv tau sau ntawv yuav Amaril, haus 4 mg thaum sawv ntxov. Tom qab ntawd hauv qhov chaw kuaj mob tsis muaj kev pab dawb Amaril, lawv hloov nws nrog Glimepirid, nyiaj siv rau cov qauv siv. Kuv sim coj nws hauv tib cov tshuaj - qab zib dhia mus txog 12 mmol / l (nws siv los ua tsis siab dua 8). Tus kws kho mob nce qhov koob tshuaj rau 6 mg, txhua yam zoo li yuav tsis zoo, tab sis kuv tseem yuav Amaril. Thiab ntxiv, 4 mg ib hnub twg tau txaus rau kuv. Tab sis kuv yuav zaum rov qab mus rau ib qho pub dawb, vim tias kuv tseem yuav cov tshuaj noj plawv thiab cov ntsiav tshuaj roj. Nws yog qhov kev tu siab uas tau tso tseg dawb Amaril.
Cov neeg kho mob ib txwm ntseeg hais tias hom ntshav qab zib hom 2 tsis yog tsuas yog ib tug kabmob los ntawm kev ua kom tsis zoo thiab ua rau lub neej tsis muaj zog xwb, tabsis kuj los ntawm qhov tsis muaj peev xwm txaus siab rau lub neej, ntawm kev ntxhov siab. Yuav kom ua tib zoo teb lawv, koj yuav tsum yog tus neeg coj tau zoo, sib hlub.

Cov lus qhia rau kev siv ntsiav tshuaj

Daim ntawv yuav tshuaj los ntawm tus kws kho mob tshwj xeeb yog qhov mob tseem ceeb uas koj tuaj yeem yuav cov tshuaj Glimepiride. Thaum muas tshuaj, nws yog kev cai them rau cov lus qhia uas tau hais tseg rau hauv cov lus qhia sau nrog.

Qhov ntau npaum ntawm cov tshuaj thiab lub sijhawm kho yog txiav txim los ntawm tus kws kho keeb, raws li qib glycemia ntawm tus neeg mob thiab nws lub xeev kev noj qab haus huv. Thaum noj Glimepiride, cov lus qhia rau kev siv muaj cov ntaub ntawv uas nws xub pib haus 1 mg ib hnub ib zaug. Ua kom tau qhov zoo tshaj plaws ntawm kev nqis tes ua tshuaj, qhov tshuaj no tuaj yeem siv los tswj cov qib qab zib kom ib txwm muaj.

Yog tias koob tshuaj qis kawg nkaus (1 mg) tsis muaj txiaj ntsig, cov kws kho mob sau maj mam 2 mg, 3 mg lossis 4 mg ntawm cov tshuaj ib hnub. Tsawg tsawg zaus, qhov ntau npaum li cas tuaj yeem raug nce ntxiv rau 3 mg ob zaug ib hnub nyob rau hauv kev saib xyuas nruj ntawm kws kho mob.

Cov ntsiav tshuaj yuav tsum tau ua kom tiav, tsis yog zom thiab ntxuav nrog kua. Yog tias koj hla kev noj tshuaj, koj tsis tuaj yeem siv tshuaj ntau dua ob zaug.

Ua ke nrog glimepiride nrog insulin, qhov koob tshuaj ntawm cov tshuaj hauv nqe lus nug tsis tas yuav hloov pauv. Kev kho tshuaj Insulin yog kho nrog qhov tsawg kawg nkaus, maj mam nce ntxiv. Kev siv sib xyaw ua ke ntawm ob qho tshuaj yuav tsum muaj kev tshwj xeeb los ntawm kws kho mob.

Thaum hloov cov kev kho mob, piv txwv li, qhov hloov pauv los ntawm lwm tus neeg sawv cev tiv thaiv kab mob rau glimepiride, lawv pib nrog cov koob tshuaj tsawg kawg nkaus (1 mg).

Cov kev hloov pauv ntawm kev siv tshuaj insulin mus rau kev noj tshuaj Glimepiride yog ua tau, thaum tus neeg mob khaws cov lus zais ntawm cov kabmob pancreatic beta hlwb hauv cov ntshav qab zib hom 2. Raws li kev saib xyuas ntawm tus kws kho mob, cov neeg mob noj 1 mg ntawm cov tshuaj ib hnub ib zaug.

Thaum muas lub tshuaj tiv thaiv kab mob, koj yuav tsum them sai sai rau nws qhov tas sij hawm. Rau glimepiride, nws yog 2 xyoos.

Cov tshuaj tiv thaiv thiab kev tsis haum

Zoo li lwm yam tshuaj, Cov tshuaj Glimepiride contraindications thiab cov txiaj ntsig tsis zoo yuav yog vim li cas vim li cas nws txoj kev siv txwv tsis pub rau qee pawg neeg mob.

Txij li cov tshuaj muaj pes tsawg leeg ntawm cov ntsiav tshuaj suav nrog cov tshuaj uas ua rau muaj kev tsis haum tshuaj, ib qho tseem ceeb contraindications ntawm cov tshuaj no hypoglycemic yog hypersensitivity rau cov Cheebtsam.

Ib qho ntxiv, qhov tau txais ntawm cov nyiaj yog txwv thaum:

mob ketoacidosis,
mob ntshav qab zib-insulin
mob ntshav qab zib coma, precoma,
lub raum lossis mob siab ua haujlwm tsis ua haujlwm,
coj menyuam
pub niam mis.

Cov neeg tsim tawm ntawm cov tshuaj no tau ua ntau yam kev kho mob thiab cov kev kawm tom qab muag tau. Raws li cov ntsiab lus, lawv muaj peev xwm ua ib daim ntawv teev cov kev mob tshwm sim, uas suav nrog:

Nyob rau hauv cov ntaub ntawv ntawm overdose, hypoglycemia tshwm sim, kav los ntawm 12 mus rau 72 teev. Raws li kev noj ntau ntau, tus neeg mob muaj cov tsos mob li nram no:

mob nyob rau hauv sab xis,
bouts ntawm xeev siab thiab ntuav,
kev zoo siab
kev mob siab rau txoj leeg leeg (tshee),
nce toj zog nkees
convulsions thiab impaired kev sib koom tes,
coma kev loj hlob.

Cov tsos mob saum toj no feem ntau tshwm sim los ntawm kev nqus ntawm cov tshuaj hauv cov hnyuv. Raws li kev kho mob, mob plab zom mov lossis ntuav yog qhov tsim nyog. Txhawm rau ua qhov no, siv cov pa roj carbon activated lossis lwm yam adsorbents, nrog rau cov neeg ua kom zoo nkauj. Tej zaum yuav muaj qee zaum mob pw hauv tsev kho mob ntawm tus neeg mob thiab tso ntshav qabzib rau lub cev.

Kev cuam tshuam nrog lwm yam tshuaj

Rau ntau tus neeg mob ntshav qab zib, lo lus nug tshwm sim seb Glimepiride tuaj yeem noj nrog lwm yam tshuaj ntxiv rau kev txhaj tshuaj insulin. Nws tsis yog yooj yim heev los muab lus teb. Muaj cov npe ntau heev ntawm cov tshuaj uas tuaj yeem muaj qhov sib txawv ntawm cov txiaj ntsig ntawm glimepiride. Yog li, qee qhov nce nws cov nyhuv hypoglycemic, thaum lwm tus, ntawm qhov tsis sib xws, txo nws.

Hauv qhov no, cov kws kho mob tau pom zoo kom lawv cov neeg mob qhia txhua qhov kev hloov pauv hauv lawv lub xeev kev noj qab haus huv, nrog rau cov kab mob ntsig txog ntshav qab zib.

Lub rooj qhia cov tshuaj tseem ceeb thiab tshuaj uas cuam tshuam rau glimepiride. Lawv siv ua ke yog qhov tsis txaus siab, tab sis qee kis nws tuaj yeem raug kho nyob rau hauv kev saib xyuas nruj ntawm tus kws kho mob tshwj xeeb.

Cov tshuaj uas tuaj yeem txhim kho qhov kev tiv thaiv hypoglycemic yog:

cov tshuaj insulin
Fenfluramine,
Fibrates
coumarin derivatives,
Disopyramides,
Allopurinol,
Chloramphenicol
Cyclophosphamide,
Feniramidol
Fluoxetine,
Guanethidine,
MAO inhibitors, PASK,
Phenylbutazone
Sulfonamides,
ACE inhibitors
anabolics
Ntsuas neeg tua neeg,
Isophosphamides,
Miconazole
Pentoxifylline
Azapropazone
Tetracycline
quinolones.

Cov tshuaj noj uas ua kom cov suab thaj txo qis thaum siv ua ke nrog glimepiride:

Tshuaj Acetazolamide.
Corticosteroids.
Diazoxide.
Kev tshuaj ntsuab.
Sympathomimetics.
Tshuaj qaug cawv
Progestogens.
Phenytoin.
Cov thyroid hormones.
Estrogens.
Phenothiazine.
Glucagon.
Rifampicin.
Barbiturates
Nicotinic acid
Adrenaline.
Coumarin derivatives.

Koj kuj yuav tsum tau ceev faj txog cov tshuaj xws li cawv thiab histamine H2 receptor blockers (Clonidine thiab Reserpine).

Noj cov tshuaj txij nkawm tuaj yeem ua rau ob leeg nce thiab txo theem ntawm glycemia hauv cov neeg mob.

Tus nqi, tshuaj xyuas thiab analogues tshuaj

Koj tuaj yeem yuav cov tshuaj no hauv cov chaw muag tshuaj tsis tu ncua lossis ntawm cov khw muag khoom lub vev xaib, tom qab pom daim duab ntawm pob tshwj xeeb ua ntej.

Nws tseem muaj peev xwm kom tau txais glimepiride ntawm cov ntsiab lus nyiam.

Rau Glimepiride, tus nqi nws txawv nyob ntawm daim ntawv ntau npaum li cas thiab cov naj npawb ntawm cov ntsiav tshuaj hauv pob.

Hauv qab no yog cov lus qhia txog tus nqi ntawm cov tshuaj (Pharmstandard, Russia):

Glimepiride 1 mg - los ntawm 100 txog 145 rubles,
Glimepiride 2 mg - los ntawm 115 txog 240 rubles,
Glimepiride 3 mg - los ntawm 160 txog 275 rubles,
Glimepepiride 4 mg - los ntawm 210 txog 330 rubles.

Raws li koj tuaj yeem pom, tus nqi tau zoo rau txhua tus neeg mob, tsis hais txog qib lawv cov nyiaj tau los. Hauv Is Taws Nem koj tuaj yeem pom ntau cov kev txheeb xyuas txog cov tshuaj. Raws li txoj cai, cov ntshav qab zib tau txaus siab rau kev ua ntawm cov tshuaj no, thiab dhau li ntawd, koj yuav tsum tau haus nws tsuas yog ib hnub ib zaug.

Vim tias muaj kev phiv los sis contraindications, tus kws kho mob tuaj yeem sau ntau lub hauv paus hloov chaw. Ntawm lawv, cov tshuaj zoo ib yam (muaj tib lub tshuaj zoo sib xws) thiab cov tshuaj muaj yees (muaj cov tshuaj sib txawv, tab sis muaj cov nyhuv zoo sib xws) muaj qhov sib txawv.

Cov khoom nrov tshaj plaws uas muaj cov khoom ua nrog tib yam yog:

Ntsiav tshuaj Glimepiride Teva yog cov tshuaj zoo uas txo cov ntshav qabzib. Cov tseem ceeb tuam txhab tsim yog neeg Ixayees thiab Hungary. Hauv Glimepirid Teva, cov lus qhia muaj yuav luag tib cov lus qhia ntsig txog nws siv. Txawm li cas los xij, cov tshuaj noj txawv ntawm cov tshuaj hauv tsev. Tus nqi nruab nrab ntawm 1 pob ntawm Glimepiride Teva 3 mg No. 30 yog 250 rubles.
Glimepiride Canon yog lwm cov tshuaj txhim khu kev qha nyob rau hauv kev sib ntaus tawm tsam muaj ntshav siab glycemia thiab mob ntshav qab zib. Kev tsim khoom ntawm Glimepiride Canon kuj tseem nyob hauv Russia los ntawm cov chaw tsim tshuaj txog kev lag luam Canonpharma ntau lawm. Glimepiride Canon tsis muaj qhov sib txawv tshwj xeeb, cov lus qhia qhia tib yam contraindications thiab muaj kev phom sij. Tus nqi nruab nrab ntawm Glimepiride Canon (4 mg No. 30) yog 260 rubles. Cov tshuaj Glimepirid Canon muaj cov tshuaj ntau ntau thiab tuaj yeem siv tau thaum cov tshuaj tsis haum rau tus neeg mob.

Muaj ntau cov tshuaj uas muaj cov kev kho zoo sib xws, piv txwv:

Metformin yog ib tus neeg sawv cev hypoglycemic nrov. Qhov tseem ceeb ntawm tib lub npe (metformin), maj mam txo cov ntshav qabzib thiab yuav luag tsis ua rau muaj ntshav qab zib. Txawm li cas los xij, Metformin muaj cov npe loj ntawm cov kev tiv thaiv thiab cov kev mob tshwm sim. Tus nqi nruab nrab ntawm cov tshuaj Metformin (500 mg No. 60) yog 130 rubles. Txij li cov tshuaj tivthaiv no yog ib feem ntawm cov tshuaj loj, koj tuaj yeem nrhiav ntau hom npe - Metformin Richter, Canon, Teva, BMS.
Lwm cov tshuaj rau ntshav hypoglycemic - Siofor 1000, Vertex, Diabeton MV, Amaril, thiab lwm yam.

Yog li, yog tias rau qee qhov laj thawj glimepiride tsis haum, analogues tuaj yeem hloov nws. Txawm li cas los xij, cov cuab yeej no muaj txiaj ntsig zoo hauv kev txhim kho hyperglycemia.

Cov ntaub ntawv hais txog kev ua haujlwm zoo tshaj plaws rau cov piam thaj hauv qab zib muaj nyob hauv video hauv tsab xov xwm no.

Glimepiride - antidiabetic, tshuaj hypoglycemic.
Glimepiride yog ib yam tshuaj hypoglycemic uas nquag thaum noj ntawm qhov ncauj, uas yog pawg sulfonylurea. Nws tuaj yeem siv rau tshuaj insulin-mob ntshav qab zib mellitus.
Glimepiride ua feem ntau los ntawm kev txhawb cov tso tawm ntawm insulin los ntawm pancreatic beta hlwb.
Ib yam li nrog lwm cov sulfonylureas, cov nyhuv no yog nce los ntawm kev nce siab ntawm cov hlwb ua kom yuag rau lub cev kev ua rau lub zog ntawm cov kua nplaum. Tsis tas li ntawd, glimepiride muaj cov txiaj ntsig transpancreatic, kuj tseem yog cov yam ntxwv ntawm lwm cov sulfonylureas.
Sulfonylurea npaj tswj cov tshuaj insulin kom tsis txhob raug kaw los ntawm kaw ATP-cov tub ntxhais hluas cov pa roj carbon monoxide channel uas nyob hauv pancreatic beta cell membrane. Kaw cov poov tshuaj channel ua rau depolarization ntawm beta tes thiab, vim li ntawm kev qhib cov calcium calcium kab, ua rau muaj kev nce ntxiv hauv kev nkag mus ntawm cov calcium hauv lub cell, uas, nyeg, ua rau muaj kev tso tawm ntawm insulin los ntawm exocytosis.
Glimepiride, nrog tus nqi hloov pauv siab, khi rau cov protein ntawm beta-cell membrane cuam tshuam nrog ATP-tos cov poov tshuaj channel, txawm li cas los xij, qhov chaw nyob ntawm nws qhov chaw khi yog qhov txawv ntawm qhov chaw khi ntawm sulfonylurea npaj.
Posapancretic kev ua si
Cov teebmeem tom qab lub cev zoo li suav nrog, piv txwv, txhim kho qhov rhiab ntawm peripheral cov ntaub so ntswg rau insulin thiab txo qis kev siv cov tshuaj insulin los ntawm daim siab.

Kev taw qhia rau kev siv:
Tshuaj Glimepiride Nws yog siv los kho tsis-insulin-tiv thaiv hom II mob ntshav qab zib mellitus yog tias cov ntshav qab zib tsis tuaj yeem tswj tau zoo tsuas yog los ntawm kev noj zaub mov zoo, tawm dag zog thiab poob phaus.

Txoj kev siv:
Kev kho ntshav qab zib kom vam meej yog nyob ntawm cov neeg mob ua raws li kev noj zaub mov zoo, kev tawm dag zog txhua lub sijhawm, thiab tshuaj xyuas cov ntshav thiab ntshav qabzib ntau ntxiv. Kev tsis tsom kwm ntawm kev noj zaub mov los ntawm cov neeg mob tsis tuaj yeem them nyiaj los ntawm kev noj tshuaj lossis tshuaj insulin.
Tshuaj Glimepiride siv los ntawm cov neeg laus.
Qhov ntau npaum li cas yog nyob ntawm kev tshwm sim ntawm cov ntshav thiab zis tawm ntawm lub ntsej muag. Thawj koob tshuaj yog 1 mg ntawm glimepiride ib hnub. Yog tias cov koob tshuaj ntawd tso cai rau kev tswj tus mob, nws yuav tsum tau siv rau kev kho kom zoo.
Yog tias kev tswj glycemic tsis pom zoo, qhov koob tshuaj yuav tsum tau nce rau 2, 3 lossis 4 mg ntawm glimepiride ib hnub nyob rau theem (nrog rau ncua sijhawm ntawm 1-2 lub lis piam).
Ib koob tshuaj ntau dua 4 mg ib hnub twg muab cov txiaj ntsig zoo tshaj plaws tsuas yog hauv qee kis. Qhov kev txhaj tshuaj ntau tshaj plaws yog 6 mg ntawm glimepiride ib hnub.
Yog tias qhov siab tshaj plaws txhua hnub ntawm metformin tsis muab glycemic txaus tswj, concomitant kev kho mob nrog glimepiride tuaj yeem pib.
Ua raws li kev noj tshuaj ua ntej ntawm metformin, glimepiride yuav tsum tau pib nrog kev txhaj tshuaj qis, uas tom qab ntawd tuaj yeem maj mam nce mus rau qhov siab tshaj plaws txhua hnub, tsom mus rau theem yam xav tau ntawm kev tswj metabolic. Kev sib xyaw ua ke yuav tsum tau ua nyob rau hauv kev saib xyuas ntawm kws kho mob.
Yog tias qhov siab tshaj plaws niaj hnub noj ntawm glimepiride tsis muab glycemic tswj tau txaus, concomitant insulin txoj kev kho tuaj yeem pib yog tsim nyog. Tom qab ua ntej tshaj tawm ntawm cov tshuaj glimepiride, kev kho tshuaj insulin yuav tsum pib nrog kev siv tshuaj tiv thaiv qis, uas tom qab ntawd tuaj yeem nce ntxiv, tsom mus rau theem yam xav tau ntawm kev tswj metabolic. Kev sib xyaw ua ke yuav tsum tau ua nyob rau hauv kev saib xyuas ntawm kws kho mob.
Feem ntau, ib koob tshuaj glimepiride ib hnub txaus. Nws raug nquahu kom noj sai ua ntej lossis thaum noj tshais lossis - yog tias tsis muaj pluas tshais - tsis ntev lossis ua ntej thawj pluas noj. Cov kev ua yuam kev hauv kev siv tshuaj, piv txwv li, hla kev siv tshuaj ntxiv, tsis tuaj yeem kho qhov tseeb los ntawm kev noj tshuaj txuas ntxiv ntawm cov koob tshuaj dua. Cov ntsiav tshuaj yuav tsum tau nqos yam tsis muaj kev ntxo, ntxuav nrog kua.
Yog tias tus neeg mob tau mob hypoglycemic rau noj glimepiride ntawm ib koob tshuaj 1 mg ib hnub, qhov no txhais tau hais tias tus kab mob tsuas tuaj yeem tswj tau los ntawm kev ua raws li kev noj haus xwb.
Txhim kho kev tswj ntshav qab zib tau nrog los ntawm kev nkag siab ntau ntxiv rau cov tshuaj insulin, yog li qhov kev xav tau glimepiride yuav txo qis thaum lub sijhawm kho. Txhawm rau kom tsis txhob mob hypoglycemia, cov koob tshuaj yuav tsum maj mam txo qis lossis kev kho yuav tsum cuam tshuam txhua yam. Qhov xav tau qhov ntsuas cov tshuaj kuj tseem tuaj yeem tshwm sim yog tias tus neeg mob lub cev qhov hnyav lossis kev ua neej pauv lossis lwm yam ua rau muaj kev pheej hmoo ntawm hypo- lossis hyperglycemia.
Hloov los ntawm cov tshuaj tiv thaiv kab mob rau qhov ncauj rau glimepiride.
Los ntawm lwm cov tshuaj tiv thaiv kab mob hauv qhov ncauj, nws feem ntau muaj peev xwm hloov mus rau glimepiride. Thaum muaj kev hloov pauv zoo li no, lub zog thiab ib nrab ntawm lub neej ntawm tus neeg saib xyuas yav dhau los yuav tsum raug suav nrog. Qee qhov xwm txheej, tshwj xeeb tshaj yog tias cov tshuaj tiv thaiv kab mob ua kom ntev li ib nrab-lub neej (piv txwv, chlorpropamide), nws raug nquahu kom tos ob peb hnub ua ntej pib glimepiride. Qhov no yuav txo qhov kev pheej hmoo ntawm hypoglycemic tshua vim lub txiaj ntsig ntxiv ntawm ob tus neeg sawv cev.
Qhov pom zoo kom pib siv yog 1 mg ntawm glimepiride ib hnub. Raws li tau sau tseg saum toj no, cov koob tshuaj muaj peev xwm nce ntxiv hauv cov qib, coj mus rau hauv tus account kev xav rau cov tshuaj.
Hloov los ntawm insulin rau glimepiride.
Muaj qee qhov tshwj tsis yog, cov neeg mob ntshav qab zib hom II uas noj tshuaj insulin tuaj yeem pom tias hloov nws nrog glimepiride. Xws li kev hloov pauv yuav tsum tau nqa tawm los ntawm kev saib xyuas ntawm kws kho mob.

Phiv los sis:
Xav txog qhov kev paub dhau los ntawm kev siv glimepiride thiab lwm yam sulfonylurea derivatives, nws yog qhov yuav tsum tau coj mus rau hauv tus lej muaj cov kev tsis haum siab uas tau piav qhia hauv qab no los ntawm cov chav kawm ntawm cov kab mob hauv kev ua haujlwm tsawg zuj zus: feem ntau ≥ 1/10, feem ntau: ≥ 1/100 rau glimepiride tshuaj rau txo cov ntshav qab zib hauv ntshav qab zib