Torvacard: cov lus qhia rau kev siv, cim, xyuas thiab analogues

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb ThorvacardCov. Kev tshuaj xyuas cov neeg tuaj saib lub tsev kawm ntawv - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Torvacard statin hauv lawv cov kev coj ua tau hais tawm. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov cim ntawm Torvacard nyob rau hauv muaj cov qauv txheej txheem qauv. Siv los txo cov roj (cholesterol) thiab tiv thaiv cov kab mob plawv rau cov neeg laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab lactation.

Thorvacard - lipid-txo tshuaj los ntawm cov pab pawg ntawm statins. Xaiv cov kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl-coenzyme A rau mevalonic acid, uas yog ib qho ua ntej rau steroids, suav nrog cov roj (cholesterol). Hauv lub siab, cov roj triglycerides thiab cov roj (cholesterol) nyob rau hauv VLDL, nkag mus rau cov ntshav ntshav thiab raug thauj mus rau cov ntaub so ntswg. Los ntawm VLDL, LDL yog tsim thaum muaj kev cuam tshuam nrog LDL receptors. Atorvastatin (cov tshuaj tseem ceeb ntawm cov tshuaj Torvard) txo cov ntshav plasma cholesterol (Ch) thiab lipoproteins los ntawm kev tiv thaiv HMG-CoA reductase, muab cov roj cholesterol hauv lub siab thiab nce cov LDL receptors hauv lub siab rau ntawm lub ntsej muag ntawm tes, uas ua rau nce siab thiab catabolism ntawm LDL Cov.

Atorvastatin txo qhov tsim ntawm LDL, ua rau muaj qhov tshaj tawm thiab pheej ua ntxiv rau hauv cov dej num ntawm LDL receptors. Torvacard txo qis LDL ntau ntau hauv cov neeg mob homozygous tsev neeg hypercholesterolemia, uas feem ntau tsis txaus siab los kho nrog lwm tus neeg mob hypolipidemic.

Nws txo cov theem ntawm cov roj (cholesterol) tag nrho los ntawm 30-46%, LDL - los ntawm 41-61%, apolipoprotein B - los ntawm 34-50% thiab triglycerides - los ntawm 14-33%, ua rau muaj qhov nce ntawm HDL-C thiab apolipoprotein A. Dose-dependently txo qib ntawm LDL hauv cov neeg mob nrog homozygous cov kab mob siab hypercholesterolemia tiv taus kev kho mob nrog lwm cov tshuaj lipid.

Muaj pes tsawg leeg

Atorvastatin calcium + excipients.

Cov Tshuaj Pharmacokinetics

Kev tshem tawm yog qhov siab. Khoom noj khoom haus me ntsis txo qhov nrawm thiab lub sijhawm nqus ntawm kev nqus ntawm cov tshuaj (los ntawm 25% thiab 9%, feem), txawm li cas los xij, txo cov roj cholesterol LDL zoo ib yam li cov tshuaj atorvastatin tsis muaj zaub mov. Qhov kev nkag siab ntawm atorvastatin thaum thov thaum yav tsaus ntuj yog qis dua thaum sawv ntxov (kwv yees li 30%). Txoj kab sib txuas ntawm qhov txheeb ze ntawm cov neeg nqus ntawm cov tshuaj thiab cov koob tshuaj tau qhia tawm. Nws yog metabolized feem ntau hauv lub siab. Nws yog tawm hauv cov hnyuv nrog cov kua tsib tom qab mob hepatic thiab / lossis cov kab mob hnyav ntxiv (tsis yauv ua kom nkag mus rau hauv lub cev). Qhov kev cuam tshuam tiv thaiv kev ua haujlwm tiv thaiv HMG-CoA reductase tseem muaj txog li 20-30 teev vim muaj cov tshuaj metabolites. Tsawg dua 2% ntawm kev noj tshuaj hauv qhov ncauj yog txiav txim siab nyob rau hauv cov zis. Nws tsis yog nyob hauv tus kab mob hemodialysis.

Cov Khoom Qhia

• hauv kev sib xyaw nrog kev noj zaub mov kom txo tau cov theem siab ntawm tag nrho cov roj (cholesterol), roj cholesterol-LDL, apolipoprotein B thiab triglycerides thiab nce roj cholesterol-HDL rau cov neeg mob thawj hypercholesterolemia, heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia (hom 2a thiab 2) ,
• hauv kev sib xyaw nrog kev noj zaub mov noj rau kev kho mob ntawm cov neeg mob uas tau txais txiaj ntsig ntshav ntau ntau (yam 4 raws li Fredrickson) thiab cov neeg mob dysbetalipoproteinemia (hom 3 raws li Fredrickson), hauv kev kho kev noj zaub mov tsis muaj txiaj ntsig,
• kom txo qis ntawm tag nrho cov roj (cholesterol) thiab LDL-C hauv cov neeg mob homozygous tsev neeg hypercholesterolemia, thaum kev noj zaub mov noj thiab lwm yam kev kho mob tsis muaj tshuaj tsis zoo txaus (raws li qhov txuas rau lipid-txo kev kho, suav nrog autohemotransfusion ntawm LDL-purified ntshav),
• cov kab mob ntawm cov hlab plawv (hauv cov neeg mob uas muaj kev pheej hmoo ntau ntxiv rau cov kab mob plawv - cov neeg laus dua 55 xyoos, haus luam yeeb, mob ntshav siab, ntshav qab zib mellitus, mob hlab ntsha hauv lub cev, mob hlab ntsha tawg, sab laug ventricular hypertrophy, protein / albuminuria, cov hlab ntshav hlab ntshav hauv cov neeg nyob ze ), suav nrog tawm tsam keeb kwm ntawm dyslipidemia - theem nrab prophylaxis nrog lub hom phiaj ntawm kev txo qis kev pheej hmoo tag nrho ntawm txoj kev tuag, myocardial infarction, mob stroke, rov pw hauv tsev kho mob rau angina pectoris thiab xav tau tus txheej txheem kho kom rov zoo siab.

Tso Tawm Cov Ntawv

10 mg, 20 mg thiab 40 mg zaj duab xis-ntsiav tshuaj.

Cov lus qhia rau kev siv thiab regimen

Ua ntej kev teem caij Torvacard, tus neeg mob yuav tsum qhia kev noj haus kom tsis txhob lipid-txo cov zaub mov, uas nws yuav tsum tau txuas ntxiv mus kom thoob rau txhua lub sijhawm ntawm kev kho.

Thawj koob tshuaj yog qhov nruab nrab ntawm 10 mg ib hnub ib zaug. Qhov kev txhaj tshuaj nws txawv ntawm 10 txog 80 mg ib hnub ib zaug. Cov tshuaj tuaj yeem siv sijhawm txhua lub sijhawm ntawm ib hnub, tsis hais lub sijhawm noj mov. Cov koob tshuaj yog xaiv rau hauv kev txiav txim siab thawj theem ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ib leeg rau ib leeg. Thaum pib kho thiab / lossis thaum qhov nce ntxiv ntawm lub tshuaj Torvacard, nws yog qhov yuav tsum tau soj ntsuam cov ntshav lipid ntau ntau txhua 2-4 lub lis piam thiab kho qhov tshuaj raws li. Qhov tshuaj ntau tshaj txhua hnub yog 80 mg hauv 1 koob tshuaj.

Nyob rau hauv thawj hypercholesterolemia thiab sib xyaw hyperlipidemia, feem ntau, ib koob tshuaj 10 mg ntawm Torvacard ib hnub ib zaug yog txaus. Cov txiaj ntsig kho tau zoo pom tom qab 2 lub lis piam, raws li txoj cai, thiab cov txiaj ntsig kho siab kawg feem ntau pom tom qab 4 lub lis piam. Nrog kev kho mob ntev, cov nyhuv no mob tsawv.

Sab sij huam

• mob taub hau
• asthenia
• insomnia
• kiv taub hau
• tsaug zog
• npau suav phem,
• amnesia
• kev nyuaj siab
• peripheral neuropathy
• ataxia
• paresthesia
• xeev siab, ntuav,
• cem quav lossis raws plab
• flatulence
• mob plab
• anorexia lossis qab los noj mov,
• myalgia
• arthralgia
• mob hlwb
• mob mob vwm
• rov qab mob
• cramps hauv plab nqaij nyuj ntawm ob txhais ceg,
• khaus tawv
• ua pob
• urticaria
• angioedema,
• anaphylactic kev poob siab,
• ua pob khaus khaus,
• polymorphic exudative erythema, suav nrog Stevens-Johnson mob
• tshuaj lom neeg mob hlwb (Lyell syndrome),
• hyperglycemia
• ntshav qab zib,
• mob hauv siab
• peripheral edema,
• impotence
• alopecia
• tinnitus
• hnyav
• malaise
• tsis muaj zog
• thrombocytopenia
• theem ob lub raum tsis ua haujlwm.

Cov Yuav Tsum Muaj

• cov kab mob nquag ua haujlwm lossis nce siab hauv kev ua haujlwm ntawm transaminases hauv cov ntshav cov ntshav (ntau dua 3 zaug piv nrog VGN) ntawm cov keeb kwm tsis paub,
• mob rau daim siab ua haujlwm (mob hnyav A thiab B ntawm Kev Siv Me Nyuam Pugh),
• cov kab mob muaj keeb, xws li lactose intolerance, lactase deficiency lossis glucose-galactose malabsorption (vim muaj lactose hauv tshuaj muaj pes tsawg leeg),
• cev xeeb tub
• kev pub mis
• Cov poj niam kev muaj me nyuam hnub nyoog uas tsis siv cov hau kev tsim nyog ntawm kev tswj kom tsis muaj menyuam,
• cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis raug),
• ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Cev xeeb tub thiab lactation

Torvacard yog contraindicated nyob rau hauv cev xeeb tub thiab lactation (pub niam mis).

Txij li cov roj (cholesterol) thiab cov tshuaj sib tov los ntawm cov roj (cholesterol) yog qhov tseem ceeb rau kev loj hlob ntawm tus me nyuam hauv plab, qhov kev pheej hmoo muaj peev xwm los tiv thaiv HMG-CoA reductase ntau dua li cov txiaj ntsig ntawm kev siv tshuaj thaum cev xeeb tub. Thaum siv lovastatin (ib qho inhibitor ntawm HMG-CoA reductase) nrog dextroamphetamine hauv thawj peb lub hlis thaum cev xeeb tub, yug menyuam ntawm cov pob txha deformation, mob pob txha-esophageal fistula, thiab anus atresia paub. Yog tias cev xeeb tub raug kuaj pom thaum kho nrog Torvacard, cov tshuaj yuav tsum tau txiav tawm tam sim ntawd, thiab cov neeg mob yuav tsum ceeb toom rau qhov muaj feem yuav ua rau muaj menyuam hauv plab.

Yog tias nws yuav tsum tau siv cov tshuaj thaum lactation, muab cov peev xwm muaj qhov tsis zoo hauv cov menyuam mos, qhov teeb meem ntawm kev txwv tsis pub niam mis rau menyuam yuav tsum raug kho.

Kev siv hauv cov poj niam ntawm lub hnub nyoog yug me nyuam yog ua tau tsuas yog siv tau txoj hauv kev tiv thaiv kom siv tau. Yuav tsum qhia rau tus neeg mob tias qhov muaj feem yuav muaj feem yuav kho tus me nyuam hauv plab.

Siv rau menyuam yaus

Cov tshuaj yog contraindicated rau siv nyob rau hauv cov menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo (kev ua hauj lwm zoo thiab kev nyab xeeb tsis tau tsim).

Cov lus qhia tshwj xeeb

Ua ntej pib siv Torvacard txoj kev kho, nws yog ib qho tsim nyog los sim ua kom tau tswj hwm hypercholesterolemia los ntawm kev kho zaub mov kom txaus, ua kom lub cev muaj zog, poob phaus hauv cov neeg mob rog thiab kho lwm yam mob.

Kev siv HMG-CoA reductase inhibitors kom txo cov ntshav lipids tuaj yeem ua rau muaj kev hloov pauv hauv cov khoom siv biochemical uas muaj kev cuam tshuam ntawm daim siab ua haujlwm. Lub siab ua haujlwm yuav tsum tau saib xyuas ua ntej pib kho, 6 lub lis piam, 12 lub lis piam tom qab pib noj Torvacard thiab tom qab txhua qhov kev nce ntxiv, thiab tseem tsis tseg (piv txwv, txhua 6 lub hlis). Kev nce ntawm kev ua si ntawm hepatic enzymes hauv cov ntshav cov ntshav tuaj yeem pom thaum kho nrog Torvacard (feem ntau hauv thawj 3 lub hlis). Cov neeg mob uas muaj qhov nce ntawm transaminase yuav tsum tau saib xyuas kom txog thaum lub enzyme rov qab los rau hauv qub. Yog tias qhov tshwm sim ALT lossis AST yog ntau dua 3 zaug siab dua li VGN, nws raug nquahu kom txo qis ntawm Torvacard lossis nres kev kho mob.

Kev kho mob nrog Torvacard tej zaum yuav ua rau myopathy (mob nqaij thiab tsis muaj zog ua ke nrog kev nce hauv CPK kev ua si los ntawm ntau dua 10 zaug piv nrog VGN). Torvacard yuav ua rau muaj kev nce ntxiv ntawm cov ntshav dej ntau ntau, uas yuav tsum tau suav nrog qhov ntsuas qhov txawv ntawm lub hauv siab. Cov neeg mob yuav tsum tau ceeb toom tias lawv yuav tsum tau sab laj nrog kws kho mob sai sai yog tias tsis hnov ​​qhov mob lossis cov leeg tsis muaj zog, tshwj xeeb tshaj yog tias lawv nrog mob tshwm sim lossis kub taub hau. Txoj kev kho Torvard yuav tsum tsis ua mus ib ntus los sis txiav tsis ua tiav yog muaj cov tsos mob ntawm tus mob myopathy lossis qhov muaj feem yuav ua rau lub raum tsis ua haujlwm vim mob rhabdomyolysis (piv txwv li, mob hnyav, mob ntshav qis, phais ntshav qis, mob hnyav, mob tshwm sim, mob hnyav ntawm lub cev, endocrine thiab electrolyte cuam tshuam thiab mob chua leeg). )

Cuam tshuam rau kev muaj peev xwm tsav lub tsheb thiab ua haujlwm nrog kev ua haujlwm

Qhov tshwm sim tsis zoo ntawm Torvacard ntawm kev muaj peev xwm tsav tsheb thiab koom nrog lwm yam uas yuav tsum muaj kev kub siab thiab ceev ntawm lub hlwb kev xav tau tsis tau ceeb toom.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv cyclosporine, fibrates, erythromycin, clarithromycin, cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob ntawm pab pawg azole, nicotinic acid thiab nicotinamide, tshuaj uas thaiv cov metabolism hauv kev sib kho los ntawm CYP450 isoenzyme 3A4, thiab / lossis kev thauj tshuaj, cov tshuaj loog ntawm atorvastatin thiab ntshav ntawm lub nce. Thaum sau cov tshuaj no, cov txiaj ntsig uas xav tau thiab qhov kev pheej hmoo ntawm kev kho yuav tsum tau ua tib zoo ntsuas, cov neeg mob yuav tsum tau soj ntsuam kom tsis tu ncua kom paub cov leeg mob lossis tsis muaj zog, tshwj xeeb tshaj yog thawj lub hlis ntawm kev kho mob thiab thaum lub sijhawm nce ntxiv ntawm ib qho tshuaj twg, ib ntus txiav txim siab cov haujlwm ntawm KFK, txawm hais tias qhov kev tswj hwm no tsis tso cai tiv thaiv kev txhim kho ntawm mob myopathy hnyav. Kho txoj kev kho Torvard yuav tsum tsis ua mus ntxiv yog tias muaj qhov cim tseg hauv CPK cov haujlwm lossis yog tias muaj kev lees paub lossis xav tias mob myopathy.

Torvacard tsis muaj qhov teeb meem loj hauv kev kho mob rau qhov kev saib xyuas ntawm terfenadine hauv cov ntshav ntshav, uas yog metabolized feem ntau los ntawm 3A4 CYP450 isoenzyme, hauv qhov no, nws tsis zoo li atorvastatin muaj peev xwm cuam tshuam loj rau pharmacokinetic yam ntawm lwm qhov chaw ntawm CYP450 3A4 isoenzyme. Nrog rau kev siv tib txhij ntawm atorvastatin (10 mg ib hnub ib zaug) thiab azithromycin (500 mg ib hnub ib zaug), qhov concentration ntawm atorvastatin hauv cov ntshav ntshav tsis hloov.

Nrog kev noj ib txhij ntawm atorvastatin thiab cov kev npaj muaj magnesium thiab aluminium hydroxides, qhov concentration ntawm atorvastatin hauv cov ntshav ntshav poob qis li 35%, txawm li cas los xij, cov neeg kawm ntawv qib qis hauv qib LDL-C tsis tau hloov pauv.

Nrog rau kev siv ua ke ntawm colestipol, ntshav ntau ntawm atorvastatin txo tsawg li thaj tsam 25%. Txawm li cas los xij, lipid-txo cov nyhuv ntawm kev sib txuam ntawm atorvastatin thiab colestipol ntau dua qhov ntawm txhua cov tshuaj ib tus zuj zus.

Nrog rau kev siv tib lub sijhawm Torvacard tsis cuam tshuam rau lub pharmacokinetics ntawm phenazone, yog li ntawd, kev sib cuam tshuam nrog lwm cov tshuaj metabolized los ntawm tib CYP450 isoenzymes tsis xav.

Thaum kawm txog kev cuam tshuam ntawm atorvastatin nrog warfarin, cimetidine, phenazone, tsis muaj cov cim ntawm thaj chaw muaj kev cuam tshuam loj tau pom.

Kev siv ib txhij siv cov tshuaj uas txo cov kev ua kom zoo ntawm cov tshuaj hormones endogenous steroid (suav nrog cimetidine, ketoconazole, spironolactone) muaj kev pheej hmoo ntawm kev txo qis cov tshuaj hormones endogenous steroid (ceeb toom yuav tsum tau siv).

Muaj tsis muaj kev cuam tshuam los ntawm kev muaj mob loj ntawm kev sib txuam ntawm atorvastatin nrog cov tshuaj tiv thaiv kab mob, nrog rau estrogens.

Nrog tib lub sijhawm siv ntawm Torvacard ntawm koob tshuaj 80 mg rau ib hnub thiab tshuaj tiv thaiv qhov ncauj muaj norethindrone thiab ethinyl estradiol, qhov nce ntau ntawm cov tshuaj norethindrone thiab ethinyl estradiol tau pom los ntawm kwv yees li 30% thiab 20%, feem. Cov nyhuv no yuav tsum raug txiav txim siab thaum xaiv qhov ncauj tsis haum rau cov poj niam tau txais Torvacard.

Nrog rau kev siv tib txhij ntawm atorvastatin ntawm koob tshuaj 80 mg thiab amlodipine ntawm koob tshuaj 10 mg, pharmacokinetics ntawm atorvastatin hauv lub xeev equilibrium tsis hloov pauv.

Nrog kev tswj hwm rov qab ntawm digoxin thiab atorvastatin ntawm koob tshuaj 10 mg, qhov sib npaug ntawm digoxin hauv cov ntshav ntshav tsis hloov. Txawm li cas los xij, thaum digoxin tau siv nrog kev sib xyaw nrog atorvastatin ntawm ib koob ntawm 80 mg rau ib hnub, qhov siab ntawm digoxin nce ntxiv txog 20%. Cov neeg mob tau txais digoxin ntau ntxiv nrog atorvastatin xav tau kev soj ntsuam.

Kev kawm txog kev sib cuam tshuam nrog lwm yam tshuaj tsis tau ua.

Analogs ntawm cov tshuaj Torvacard

Cov yam ntxwv ntawm cov tshuaj nquag:

• Tus tub sab
• Atocord
• Cov Atomax
• Atorvastatin
• Atorvox
• Atoris
• Vazator
• Lipona
• Lipoford
• Liprimar
• Liptonorm,
• Torvazin
• Tulip.

Cov tshuaj hauv cov pab pawg (pharmacological statins):

• Akorta,
• Actalipid
• Tus tub sab
• Apextatin,
• Atherostat
• Atocord
• Cov Atomax
• Atorvastatin
• Atorvox
• Atoris
• Vazator
• Vasilip
• Zokor
• Zokor Forte
• Zorstat
• Cardiostatin
• Neeg Coob
• Leskol,
• Leskol forte
• Lipobay,
• Lipona
• Lipostat
• Lipoford
• Liprimar
• Liptonorm,
• Lovacor
• Lovastatin,
• Lovasterol
• Mevacor
• Medostatin,
• Mertenil
• Aries
• Pravastatin,
• Rovacor
• Rosuvastatin,
• Rosucard
• Rosulip,
• Kwv Txhiaj Ntsuag
• SimvaHexal,
• Simvakard,
• Simvacol
• Simvalimite
• Simvastatin
• Simvastol
• Simvor
• Ib Sim Neej
• Simlo
• Dab Dab Ntxaug
• Tevastor
• Torvazin
• Tulip
• Holvasim
• Holetar.

Kev ntsuas rau siv

Torvacard 10 mg

Cov ntsiav tshuaj yog tshuaj raws li ib feem ntawm kev kho mob kom zoo.Torvacard siv rau dab tsi? Cov tshuaj yog tshuaj rau cov neeg mob kev txom nyem los ntawm cov kab hauv qab no:

• Thaum muaj mob thawj zaug hypercholesterolemia, hyperlipidemia (keeb kwm, tsis muaj mob thiab tsis sib xyaw), kev noj haus tau sau tseg thaum kho mob uas txo cov roj thiab triglycerides (yog tias, raws li cov txiaj ntsig tau los ntawm cov kev ntsuas, cov ntsuas no tau nce),,
• Nrog rau qhov nce hauv cov ntshav concentration ntawm triglycerides (hom 4 hypertriglyceremia raws li Frederickson), cov roj (cholesterol) thiab lipoprotein metabolism tsis txaus (abetalipoproteinemia thiab hypobetalipoproteinemia - tsev neeg dsetalipoproteinemia),
• Nrog rau tag nrho cov roj (cholesterol) siab thiab qhov nce ntawm cov tshuaj lipoproteins uas tsis muaj ntau ntau ua ke nrog homozygous tsev neeg hypercholesterolemia,
• Kev ua haujlwm ntawm cov hlab plawv (ischemia, ntshav qab zib mellitus, kub siab, obliterating atherosclerosis, mob ntshav qab zib ko taw syndrome, peripheral thrombosis),
• Kev tiv thaiv kab mob thib ob ntawm cov kev mob tshwm sim tom qab myocardial infarction, mob stroke, angina pectoris.

Tsis tas li, cov ntsiav tshuaj tau sau rau cov neeg mob uas muaj kev pheej hmoo rau kev txhim kho cov hlab plawv hlab plawv (haus luam yeeb, mob ntshav qab zib mellitus, hnub nyoog dhau los).

Cov lus qhia rau siv Torvacard thiab ntau npaum li cas

Thaum kho lub sijhawm, tus neeg mob yuav tsum ua raws li kev noj haus hypocholesterolemic (txwv kom qab ntsev, kib, zaub mov rog, kev siv zaub mov, zaub, dej).

Raws li cov lus qhia rau kev siv Torvacard, cov ntsiav tshuaj tau noj tag nrho (sab hauv), tsis hais zaub mov thiab sijhawm nruab hnub. Kev kho mob yog nqa tawm raws li lub tswvyim. Qhov tshuaj thawj zaug yog kaum mg (ib hnub ib zaug). Tom qab ntawd qhov nyiaj ntawm cov tshuaj nce ntxiv thiab, nyob ntawm qhov nyuaj ntawm kev kuaj mob, qhov tshuaj txhua hnub yog los ntawm kaum txog rau yim caum mg.

Thaum kho, lipid tsis nyob hauv cov ntshav tau saib lub chaw kuaj ntshav txhua ob lub lis piam. Qhov no pub rau kho kom haum raws sijhawm.

Nta ntawm daim ntawv thov ntawm Torvacard:

- Nrog homozygous cov kab mob hypercholesterolemia, qhov tshuaj pom zoo txhua hnub yog 80 mg,
- Txoj kev muab tshuaj tsis tuaj yeem hloov kho thaum muaj mob hauv lub siab thiab lub raum,
- Cov kev paub los ntawm kev muab tshuaj rau kev xyaum ua me nyuam yaus yog li tsawg, yog li, cov menyuam yaus yuav tsum mus pw hauv tsev kho mob thaum kho (kom tsis txhob muaj qhov tshwm sim tsis zoo ntawm cov tshuaj),
- Cov neeg laus zam cov ntsiav tshuaj zoo, yog li tsis tas yuav hloov cov tshuaj kom tsis haum.

Cov neeg mob uas siv cov tshuaj tiv thaiv anticoagulant lossis coumarin, ua ntej kev teem caij Torvacard, raug pom zoo kom ua qhov kev soj ntsuam rau PV (lub sijhawm prothrombin). Kev saib xyuas yuav tsum tau ua thaum ua ke nrog HMG-CoA reductase inhibitors thiab fibrates.

Contraindications thiab kev noj ntau dhau

Cov ntsiav tshuaj muaj ntau yam contraindications, yog li ntawd, raug kho los ntawm kws kho mob tom qab kuaj mob ntxaws ntawm tus neeg mob. Nws tsis pom zoo kom kho Torvacard nrog pathologies:

• Hypersensitivity rau lub ntsiab nquag khoom xyaw lossis ntxiv khoom xyaw (magnesium oxide, microcrystalline cellulose, lactose monohydrate, magnesium stearate),
• Mob mob siab
• Ib nplooj siab enzymes tsis paub kev mob hlwb,
• Cov menyuam yaus hnub nyoog qis dua 18 xyoo (kev nyab xeeb, kev ua tau zoo thiab kev pom zoo ntawm cov tshuaj tsis tau tsim hauv chaw kho mob), tshwj tsis yog kev kho tus mob heterozygous tsev neeg hypercholesterolemia,
• Concurrent administration ntawm protease inhibitors (hauv kev kho mob HIV).

Cov tshuaj tsis tau sau tseg rau cov poj niam nyob rau theem phiaj xwm lossis kev xeeb tub. Txij li thaum atorvastatin kis mus rau hauv niam mis, nws tsis yog tus kws kho lub sijhawm lactation.

• los ntawm lub hauv nruab nrab lub paj hlwb - pw tsis txaus, mob taub hau, kiv taub hau, tsis hnov ​​mob, leeg tsis muaj zog,
• los ntawm cov hnyuv zom mov - xeev siab, ntuav, tso quav tsis haum, tsam plab, mob epigastric, mob rau daim siab thiab mob leeg,
• nyob rau ib feem ntawm cov leeg txheej txheem ntawm cov leeg nqaij - mob nqaij thiab pob qij txha, mob tsis hnov ​​qab ntawm cov leeg nqaij (txog kev puas tsuaj rau cov leeg nqaij ua haujlwm), cov leeg mob.

Nws tseem ua tau txoj kev loj hlob ntawm kev fab tshuaj - liab ntawm daim tawv nqaij, qhov tsos ntawm daim tawv nqaij me, khaus, tsis tshua muaj - urticaria.
Kev noj ntau tshaj tshwm sim tshwm sim los ntawm kev kho mob ncua ntev los yog tawm tsam keeb kwm ntawm ib qho kev noj tshuaj ntau npaum li cas. Hauv qhov no, tus neeg mob pw hauv tsev kho mob, kev kho mob yam ntxwv yog yam kho. Hemodialysis yuav tsis zoo.

Torvakard analogues, npe

Torvacard, zoo ib yam li lwm yam tshuaj nrog atorvastatin, tau muab faib hauv cov khw muag tshuaj yam tsis muaj tshuaj. Tab sis qhov no tsis txhais tau tias txhua tus neeg mob nws muaj peev xwm xaiv lwm yam tshuaj, uas tej zaum yuav pheej yig dua lossis kev pom zoo los ntawm tus kws muag tshuaj.

Yog tias Torvard ntsiav tshuaj tsis haum rau tus neeg mob, ces tus kws kho mob tuaj yeem sau tshuaj analogues:

Tseem ceeb - cov lus qhia rau kev siv Torvacard, nqe thiab tshuaj xyuas tsis siv rau cov analogues thiab tsis tuaj yeem siv cov lus qhia rau kev siv tshuaj ntawm cov tshuaj zoo sib xws lossis kev ua. Txhua txhua teem sijhawm kho yuav tsum ua los ntawm kws kho mob. Thaum hloov Torvacard nrog cov tshuaj tiv thaiv kab mob, nws yog ib qho tseem ceeb kom tau txais tswv yim tshwj xeeb, koj yuav tsum tau hloov kho chav kho mob, siv tshuaj, thiab lwm yam. Tsis txhob siv tshuaj rau tus kheej!

Txhua yam tshuaj yog kws kho mob txhawm rau txo cov roj (cholesterol) tag nrho, cov lipoproteins tsawg thiab triglycerides nyob hauv thawj lossis tsev neeg hypercholesterolemia. Torvacard analogs tseem muaj ntau yam kev tiv thaiv, yog li tus neeg mob kuaj rau lipid tsis muaj teeb meem ua ntej, thaum thiab tom qab kho. Cov kws kho mob qhov kev tshuaj xyuas txog cov tshuaj muaj txiaj ntsig zoo: cov tshuaj, raws li txoj cai, zoo zam - cov kev mob tshwm sim tsis tshua muaj tshwm sim, thiab kev noj tshuaj yog qhov yooj yim heev los txiav txim.

Pharmacological kev txiav txim

Hais txog rau ib pawg statins thiab renders lipid-tej nyhuvCov. Txwv tsis pub xaiv thiab kev sib tw ntawm cov enzyme uas koom nrog hauv qhov kev tsim hluav taws xob roj.

Triglycerides thiab cov roj (cholesterol) tau dhau los ua cov ncauj lus atherogenic lipoprotein nyob rau hauv lub siab, tom qab ntawd cov ntshav yuav pauv mus rau qhov khoom plig. Los ntawm kev sib tham nrog cov receptors lipoproteinsqhov tsawg kawg lawv tau hloov mus rau hauv cov lipoproteins no.

Los ntawm inhibiting HMG-CoA reductase, lipoproteins tsawg dua thiab roj hauv cov ntshav. Txo qhov qis LDL synthesis thiab nce kev ua haujlwm ntawm lawv cov receptors.

Cov tshuaj muaj peev xwm txo qis ntawm LDL nrog homozygous hypercholesterolemia roj ntsha, thaum lwm yam tshuaj tsis muaj qhov tshwm sim.

Cov tshuaj txo cov roj cholesterol los ntawm 30-46%, atherogenic lipoproteins los ntawm 41-61%, triglycerides los ntawm 14-33% thiab nce cov ntsiab lus ntawm lipoproteins nrog antiatherogenic lub zog.

Pharmacodynamics thiab pharmacokinetics

Hauv cov ntshav, qhov siab tshaj plaws ntawm cov tshuaj tshwm sim hauv 60-120 feeb. Noj noj tau kom tsawg dua ntawm kev nqus, tab sis qis dua roj muab piv rau tias tsis muaj zaub mov. Yog tias muaj daim ntawv thov thaum yav tsaus ntuj, qhov tseem ceeb ntawm cov tshuaj yuav qis dua thaum noj thaum sawv ntxov.

Nws khi rau cov ntshav protein li 98%. Nws yog metabolized hauv daim siab nrog rau kev tsim cov khoom noj nquag.

Nws yog excreted nrog bile, ib nrab-lub neej yog 14 teev. Qhov ua tau zoo ntawm cov tshuaj yog tswj vim muaj cov tshuaj metabolites txog li 30 teev. Nrog hemodialysis, nws tsis raug tawm los.

Kev taw qhia Torvakard

Torvacard ntsiav tshuaj - dab tsi yog lawv los ntawm?

Cov tshuaj yog siv ua ke nrog kev noj haus rau:

• qib txo rojatherogenic lipoproteins, triglycerides, apolipoprotein B thiab nce HDL hauv hypercholesterolemia, heterozygous thiab ua ke hypercholesterolemia (Fredrickson yam IIa thiab IIb),
• kev kho mob ntawm cov neeg mob nyob rau hauv uas cov ntsiab lus nce ntxiv triglycerides nyob rau hauv cov ntshav (IV hom raws li Fredrickson) thiab hom III raws li Fredrickson (dysbetalipoproteinemia), yog tias kev noj zaub mov tsis muaj txiaj ntsig,
• txo cov cholesterol thiab LDL nrog homozygous tsev neeg hom hypercholesterolemia,
• kev kho mob plawv thiab cov ntshav liab nyob rau hauv lub xub ntiag ntawm nce yam tseem ceeb rau kev tshwm sim ntawm kab mob plawvleeg ntshav siabcov neeg mob hnub nyoog tshaj 55 xyoos mob stroke nyob rau hauv anamnesis, albuminuriahypertrophy ntawm sab laug ventricle, haus luam yeeb, peripheral vascular kab mob,Ischemic mob plawv hauv tsev neeg mob ntshav qab zib mellitus).

Qhov tshwm sim tshaj plaws rau Torvacard yog qhov kev ceeb toom thib ob myocardial infarctionkev tuag ntxeev khostroke ntawm keeb kwm yav dhau dyslipidemia.

Cov Yuav Tsum Muaj

• daim siab mob siab rau,
• txhawb nqa qib transaminase hauv cov ntshav
• muaj cov kab mob tsis haum ntshav qabzib thiab lactose, lactase deficiency,
• Cov poj niam muaj hnub nyoog yug me nyuam tsis siv tshuaj thaiv,
• cev xeeb tub thiab pub niam mis,
• cov me nyuam hnub nyoog qis dua 18 xyoo
• ib tug neeg intolerance.

Siv maj mam siv rau cov teeb meem ntawm lub cev thiab metabolism, leeg ntshav siab, quav cawvpauv kab mob siab sepsis, hloov pauv hauv cov dej-electrolyte sib npaug, nrog mob ntshav qab zib, qaug dab peg, raug mob thiab raug phais mob loj.

Sab sij huam

Alimentary huam: mob plab, dyspepsiaxeev siab thiab ntuav, tso quav tsis txaus, hloov pauv ntawm lub siab, pancreatitis thiab kab mob siab, dajntoo.

Cov leeg mob: mob hauv cov pob qij txha thiab cov leeg, nraub qaum, mob plab hauv cov leeg ntawm ob txhais ceg, mob mob vwm.

Kev ntsuas ntsuas qhov tsis txaus ntseeg: theem hloov piam thajkev ua si nce daim siab enzymes thiab kev tsim tawm phosphokinase hauv cov ntshav.

Lwm qhov kev tshwm sim tuaj yeem suav nrog cov ntaub so ntswg peripheral edema, mob hauv siab, tinnitus, ua pob taub hau, tsis muaj zog, yuag, impotence, lub raum tsis ua haujlwm ntawm qhov xwm txheej thib ob, txo qis hauv platelet suav.

Cov ntsiav tshuaj roj nyob rau hauv qee kis raug coj los ua kev nyuaj siab, kev ua txhaum ntawm kev sib deev muaj nuj nqi, cov xwm txheej tsis tshua muaj kev puas tsuaj rau cov ntaub so ntswg mob ntsws, mob ntshav qab zib (kev loj hlob nyob ntawm cov muaj feem phom sij - yoo qabzib, mob ntshav siab, ntshav ntau lub cev, hypertriglyceridemia).

Cov lus qhia rau siv Torvacard (Txujci thiab ntau npaum li cas)

Thaum kho, tus neeg mob yuav tsum tau ua raws lipid-txo cov zaub mov noj.

Kev kho mob pib nrog 10 mg ib hnub twg, tom qab tau nce mus rau 20 mg. Kev kho mob txhua hnub yog los ntawm 10 txog 80 mg. Cov koob tshuaj yog xaiv noj rau hauv tus account kuaj ntsuas thiab tus yam ntxwv.

Cov tshuaj yog coj tsis hais noj zaub mov.

Ua ntej yuav noj thiab, yog tias tsim nyog, kho lub koob tshuaj, kev kuaj xyuas qib ntawm qib lipid yog ua.

Cov nyhuv ntawm daim ntawv thov tshwm sim tom qab 14 hnub.

Rau kev kho mob ntawm cov neeg mob homozygous hypercholesterolemia ib qho ntawm ob peb cov tshuaj uas muab cov txiaj ntsig yog Torvacard, cov lus qhia rau kev siv kom meej meej txiav txim siab qhov koob tshuaj txhua hnub, uas yog 80 mg.

Kev sib txuam

Kev siv cov tshuaj uas thaiv cov metabolism hauv kev sib kho los ntawm CYP450 enzyme, erythromycintshuaj tiv thaiv thiab cov tshuaj tiv thaiv kab mob, fibrates, cyclosporine, clarithromycin, nicotinamide, nicotinic acid cov concentration ntawm torvacard hauv cov ntshav nce ntxiv. Nyob rau tib lub sijhawm, qhov ntxim nyiam ntawm myopathy tau nce, yog li nws yog qhov tsim nyog los tswj qib ntawm CPK hauv cov ntshav.

Sib koom txais tos ntawm cov nyiaj nrog aluminium hydroxide lossis tshuaj nplaum txo qhov kev xav ntawm Torvacard, tab sis qhov no tsis cuam tshuam rau qhov ua tau haujlwm.

Ua ke nrog colestipol txo qhov kev xav zoo atorvastatintab sis lawv sib koom tes lipid-tej nyhuv surpasses txhua tus zuj zus.

Txais tos tshuaj tiv thaiv qhov ncauj thiab ib koob tshuaj txhua hnub ntawm Torvacard 80 mg nce lub ntsiab lus ethinyl estradiol hauv cov ntshav.

Siv hauv nrog nrog digoxin txo qhov concentration ntawm tom kawg los ntawm 20%.

Cov lus qhia tshwj xeeb

Ua ntej kev kho mob, koj yuav tsum sim txo cov roj (cholesterol) nrog kev noj zaub mov noj, kev kho mob rog dhau thiab cov kab mob sib kis, ua kom lub cev muaj zog.

Thaum kho, nws yog qhov tsim nyog los tswj qib ntawm AST thiab ALT. Thawj thawj zaug, kev tswj hwm yog nqa tawm ua ntej, tom qab 6 lub lis piam thiab 3 lub hlis tom qab pib kho, nrog rau tom qab kho qhov tshuaj thiab ib zaug txhua rau lub hlis. Yog hais tias theem ntawm cov enzymes nce siab dua 3 zaug, cov tshuaj yuav raug muab tso tseg.

Kev nqus Torvacard tuaj yeem ua rau cov leeg tsis muaj zog thiab mob (myopathies) thiab nce rau hauv CPK hauv cov ntshav. Yog tias koj muaj mob leeg lossis tsis muaj zog ua ke nrog kev kub taub hau, koj yuav tsum sab laj nrog kws kho mob.

Cov tshuaj raug muab tso tseg thaum muaj teeb meem lub raum tsis ua hauj lwm vim yog rhabdomyolysisCov. Nws tuaj yeem ua rau raug mob, ua haujlwm ntau, kev sib luag ntawm lub cev thiab roj ntsha tsis txaus, arterial hypotensionkis mob hnyavcramps.

Kev nkag siab Torvacard yuav ua rau muaj kev txhim kho mob ntshav qab zib mellitus hauv cov neeg mob uas muaj kev pheej hmoo siab ntxiv. Tab sis nws tsim nyog nco ntsoov tias cov txiaj ntsig ntawm kev noj cov tshuaj statins ntau dua li kev pheej hmoo ntawm ntshav qab zib, yog li tsis tas yuav tshem tawm cov tshuaj, thiab cov neeg mob uas muaj pheej hmoo yuav tsum nyob tas li saib xyuas ntawm kws kho mob.

Xyuas rau ntawm Torvakard

Cov kev tshuaj xyuas ntawm Torvacard uas muaj nyob ntawm cov xov tooj cua tau tso cai rau peb los xaus tias cov tshuaj muaj txiaj ntsig txaus. Nws yog dav kho los ntawm kws kho plawv kom txog qib qis. roj thiab tiv thaiv tus neeg mob los ntawm mob stroke thiab plawv nresCov. Tom qab siv 1-2 lub hlis, kev pom zoo txo ​​qis hauv cov qib roj cholesterol. Qee tus poj niam qhia qhov zoo txaus siab tshwm sim - poob ceeb thawj.

Ntawm qhov kev ua tsis tiav tuaj yeem hu ua qhov tseeb tias tshuaj rau cov cholesterol ua rau tuaj yeem ua insomnia thiab khaus lub cev ua pob.

Kev sib xyaw, daim ntawv ntawm cov tshuaj thiab tus nqi

Hauv cov ntsiav tshuaj convex, them nrog zaj duab xis, muaj atorvastatin calcium ntsev hauv qhov ntau npaum li 10, 20 lossis 40 g. Ntxiv rau lub hauv paus tshuaj:

1. Microcrystalline thiab hydroxypropyl cellulose,
2. Magnesium oxide thiab stearate,
3. Croscarmellose sodium
4. Lactose dawb
5. Hypromellose,
6. Silica
7. Titanium dioxide
8. Macrogol 6000,
9. talcum hmoov.

Daim ntawv yuav tshuaj. Rau Torvacard, tus nqi hauv cov khw muag tshuaj muaj raws li lawv cov ntau thiab ntau npaum li cas hauv lub thawv, piv txwv li, Torvacard 20 mg, tus nqi yog 90 ntsiav tshuaj. 1066 rub.

• 10 mg, 30 pcs. - 279 rubles,
• 10 mg, 90 pcs. - 730 rubles,
• 20 mg, 30 pcs. - 426 rub,
• 40 mg, 30 pcs. - 584 rubles,
• 40 mg, 90 pcs. –1430 rub.

Cov tshuaj yog qhov tsim nyog siv rau 4 xyoos, tsis muaj qhov tshwj xeeb rau nws txoj kev khaws cia.

Cov Tshuaj Hauv Tshuaj

Cov tshuaj hluavtaws Torvacard inhibits HMG-CoA reductase, txwv kev tshaj tawm cov roj (synthesis). Cov roj (cholesterol), triglycerides, lipoproteins nyob rau hauv cov ntshav ncig hauv cov chaw ua haujlwm.

Cov ntsiab lus siab ntawm tag nrho cov roj (OH), LDL thiab apolipoprotein B yog qhov muaj kev pheej hmoo rau atherosclerosis thiab nws cov teeb meem tshwm sim, cov theem ntawm HDL tsawg dua, ntawm qhov tsis sib thooj, cov ntsuas no.

Hauv kev sim tsiaj, nws tau pom tias statin txo cov kev sib txuam ntawm cov roj cholesterol thiab LP, tiv thaiv HMG-CoA reductase thiab tsim cov roj cholesterol. Tus naj npawb ntawm cov "tsis zoo" cov roj ntsha receptors kuj nce siab, txhim kho kev nqus ntawm hom lipoproteins no. Txo atorvastine thiab LDL synthesis.

Torvacard pab txo qis hauv tsev so hauv OS, VLDL, TG, LDL, txawm tias cov neeg mob uas tsis muaj tsev neeg hom hypercholesterolemia thiab dyslipidemia, tsis tshua teb rau lwm cov tshuaj noj.

Muaj pov thawj ntawm kev sib piv ncaj qha ntawm kev tuag nyob hauv pathologies ntawm lub plawv thiab cov hlab ntsha thiab cov ntsiab lus ntawm LDL thiab OH thiab inversely proportional rau HDL.

Torvacard thiab nws cov metabolites yog pharmacologically nquag rau tib neeg lub cev. Qhov chaw tseem ceeb ntawm lawv qhov chaw nyob yog daim siab, uas ua haujlwm ua haujlwm ntawm kev ua kom cov roj (cholesterol) thiab tshem ntawm LDL. Thaum muab piv nrog cov ntsiab lus ntawm cov tshuaj, qhov ntau npaum ntawm Torvacard cuam tshuam ntau dua nrog kev txo qis hauv LDL.

Ib koob tshuaj ib tug zuj zus raug xaiv raws li kev tshwm sim los ntawm kev kho kom rov zoo li cas.

Cov Tshuaj Pharmacokinetics

1. Xuas. Cov tshuaj noj kom nquag plias nyob rau hauv lub plab zom mov tom qab siv sab hauv, mus txog qhov zoo tshaj plaws nyob hauv thaj tsam ib mus txog ob teev. Qib ntawm kev nqus tau nce nrog nce zuj zus ntawm Torvacard. Nws qhov kev nyab xeeb yog nyob ntawm 14%, theem ntawm kev txwv tsis pub ua tawm tsam HMG-CoA reductase yog 30%. Qhov taw qhia ntawm kev siv bioavailability tsawg tau piav qhia los ntawm kev kho ua ntej kom pom tseeb hauv txoj hnyuv thiab biotransformation hauv daim siab. Khoom noj khoom haus rov qab txo tus nqi ntawm kev haus tshuaj, tab sis cais los yog sib koom noj mov thiab tshuaj tsis cuam tshuam qhov poob hauv cov "cholesterol" phemCov. Yog tias koj siv statin thaum yav tsaus ntuj, nws qhov kev txiav txim siab txo qis dua 30%, tab sis qhov kev ua haujlwm no tsis cuam tshuam txog qhov txo qis hauv qib "phem" cov roj (cholesterol).
2. Kev xa Khoom. Tshaj 98% ntawm cov tshuaj nquag khi rau cov ntshav protein. Cov kev sim ntawm nas pom tias cov tshuaj tuaj yeem hla mus rau niam mis.
3. Kev zom zaub mov. Cov tshuaj yog dav metabolized. Txog 70% ntawm nws cov kev ua rau tiv thaiv HMG-CoA reductase yog muab los ntawm metabolites.
4. Chaw Sau Ntawv. Feem ntau ntawm atorvastine thiab nws cov kev coj ua raug muab tshem tawm nrog bile tom qab ua tiav rau hauv daim siab. Kev tshem tawm statin ib nrab-lub neej yog txog 14 teev. Tom qab noj ib koob, tsis pub ntau dua 2% ntawm cov tshuaj nkag rau hauv cov zis.
5. Poj niam txiv neej thiab lub hnub nyoog nta. Hauv cov neeg muaj kev noj qab haus huv ntawm lub hnub nyoog muaj hnub nyoog, qhov feem pua ​​ntawm cov ntsiab lus statin ntau dua li cov neeg hluas, yog li ntawd, cov neeg kawm tiav qib LDL ntau dua. Hauv cov poj niam, cov ntsiab lus ntawm Torvacard hauv cov ntshav yog siab dua, tab sis qhov cuam tshuam no tsis cuam tshuam qhov feem pua ​​ntawm LDL txo. Tsis muaj pov thawj dab tsi ntawm cov menyuam yaus kev hloov pauv mus rau Torvacard.
6. Cov hlwv pathology. Cov raum tsis ua hauj lwm tsis cuam tshuam txog theem theem statin thiab tsis xav tau kev hloov kho koob tshuaj. Kev tshem tawm ntawm cov tshuaj yuav tsis txhim kho hemodialysis, txij li atorvastine khov kho khi rau cov nqaijrog.
7. Kab mob siab Cov kab mob siab ua ke nrog kev haus cawv ua rau muaj kev cuam tshuam ntawm theem ntawm cov tshuaj hauv ntshav: nws cov ntsiab lus yog nce ntxiv.

Compatibility ntawm Torvacard nrog lwm cov tshuaj

Cov ntaub ntawv nthuav tawm raws li kev hloov pauv ob peb zaug yog qhov sib piv ntawm cov xwm txheej ntawm kev siv yeeb tshuaj thiab Torvacard ib leeg.

Cov ntaub ntawv qhia hauv feem pua ​​piv yog qhov sib txawv hauv cov ntaub ntawv hais txog kev siv Torvacard cais. AUC - thaj chaw hauv qab nkhaus qhia txog qib ntawm atorvastatin rau lub sijhawm twg. C max - cov ntsiab lus siab tshaj plaws ntawm cov khoom xyaw hauv cov ntshav.

Cov tshuaj siv rau kev siv loj thiab ntau npaum li cas

Koob tshuajAUC hloovHloov C _max Cyclosporin 520 mg / 2r. / hnub, tas li.10 mg 1 p./day rau 28 hnub8.7 p.10,7 r Saquinavir 400 mg 2 p./day / Ritonavir 400 mg 2 p./day, 15 hnub40 mg 1 p./day rau 4 hnub3.9 p.4.3 p. Telaprevir 750 mg tom qab 8 teev, 10 hnub.20 mg RD7.88 p.10.6 p. Itraconazole 200 mg 1 p. / hnub, 4 hnub.40 mg RD.3.3 p.20% Clarithromycin 500g 2 r./day, 9 hnub.80 mg 1 p./day Txog 8 hnub4,4 r5.4 p. Fosamprenavir 1400 mg 2 p./ hnub, 14 hnub.10 mg ib hnub ib zaug rau 4 hnub.2.3 p.Cov. 4.04 p. Cov kua txiv kab ntxwv qaub, 250 ml 1 r. / Hnub.40 mg 1 p./day n37%16% Nelfinavir 1250 mg 2 p./ hnub, 14 hnub10 mg 1 p./day ntawm 28 d74%2.2 p. Erythromycin 0.5g 4 r./ hnub, 7 hnub.40 mg 1 p./day51%Tsis muaj hloov Diltiazem 240 mg 1 p./ hnub, 28 hnub.80 mg 1 p./day15%12% Amlodipine 10 mg, ib koob tshuaj10 mg 1 p./day33%38% Colestipol 10 mg 2 p. / Hnub, 28 lub lis piam.40 mg 1 p./day rau 28 lub lis piamtsis qhia npe26% Cimetidine 300 mg 1 r./ hnub, 4 lub lis piam.10 mg 1 p./day rau 2 lub lis piamnce txog 1%11% Efavirenz 600 mg 1 r./ hnub, 14 hnub.10 mg rau 3 hnub.41%1% Maalox TC ® 30 ml 1 r./ hnub, 17 hnub.10 mg 1 p./day rau 15 hnub33%34% Rifampin 600 mg 1 p./ hnub, 5 hnub.40 mg 1 p./day80%40% Fenofibrate 160 mg 1 p./ hnub, 7 hnub.40 mg 1 p./day3%2% Gemfibrozil 0.6 g 2R./day., 7 hnub.40 mg 1 p./day35%nce txog 1% Boceprevir 0.8g 3 r./day, 7 hnub.40 mg 1 p./day2.30 p.2.66 p.

Kev pheej hmoo ntawm cov leeg mob pob txha (rhabdomyolysis) muaj tshwm sim thaum Torvacard los sib cuag nrog cov tshuaj uas ua rau nws theem. Nws txaus ntshai los muab nws nrog cyclosporine, styripentol, telithromycin, clarithromycin, delavirdine, ketoconazole, voriconazole, posaconazole, itraconazole thiab HIV inhibitors.

Feem ntau, cov analogues uas tsis cuam tshuam nrog Torvacard tau raug xaiv. Yog li txawm li cas los xij kev txiav txim siab tau txiav txim siab los txuas rau lawv, lawv suav txhua qhov kev pheej hmoo thiab cov txiaj ntsig ntawm kev kho mob zoo li no.

Statins thiab fusidic acid tsis sib haum: atorvastatin thim tseg rau kev kho mob acid.

Yog tias tus neeg mob siv tshuaj uas ua rau muaj kev nce qib hauv cov ntshav, yuav tsum tau noj tsawg ntawm Torvacard. Yuav tsum muaj kev tshuaj xyuas tas li ntawm cov neeg mob li ntawd.

Qee qhov kev tshawb fawb thov tias statins tuaj yeem ua rau cov ntshav qab zib ntau ntau. Cov neeg mob hauv kev mob ntshav qab zib yuav tau siv tshuaj kho tus mob. Tab sis yog tias koj sib piv cov kev hem thawj no nrog kev txaus ntshai ntawm vascular kev puas tsuaj, ces kev siv statins tuaj yeem tsim nyog.

Cov sawv cev ntawm cov pab pawg muaj kev pheej hmoo (suab thaj tshaib plab mus txog 6.9 mmol / l, BMI> 30 kg / m2, siab ntawm triglycerol, kub siab) tas li soj ntsuam cov kab mob biochemical thiab qhov chaw kuaj mob.

Qee lub koomhaum pabcuam kuj tseem tuaj yeem ua rau tsis muaj qhov tsis zoo. Piv txwv li, lactose tsis haum rau ib leeg neeg galactose tsis kam lees lossis tsis muaj lactase.

Cov neeg mob uas muaj lub plawv mob rau lub plawv thiab cov neeg mob uas yuav muaj mob pheej hmoo rau angina pectoris Torvacard tau sau ua ke nrog kev noj haus zoo.

Torvacard: kev taw qhia thiab contraindications rau siv

Cov neeg laus uas tsis muaj cov cim kev tiv thaiv mob plawv, tab sis nrog qhov tsim nyog ua ntej rau nws tsim (kub siab, haus luam yeeb, muaj hnub nyoog, HDL qis, muaj kab mob siab rau kev mob plawv), yog cov tshuaj rau kev tiv thaiv mob stroke, myocardial infarction, thiab txo kev pheej hmoo ntawm kev kho mob hauv cov hlab ntshav.

Tus mob ntshav qab zib hom 2 tsis muaj cov tsos mob ntawm kev mob plawv, tab sis nrog cov kev pheej hmoo xws li retinopathy, albuminuria (muaj protein nyob hauv cov zis uas qhia txog lub raum pathology), haus luam yeeb lossis ntshav siab, statin yog tshuaj rau kev tiv thaiv kev mob plawv thiab mob stroke.

Nrog rau cov kab mob ntsig txog lub plawv mob hnyav, atorvastatin tau sau tseg rau kev tiv thaiv kev ua kom mob siab thiab tsis ua kom mob plawv thiab mob hlab ntsha tawg, txhawm rau txhim kho txoj kev kho tus mob, thiab txo txoj kev pheej hmoo pw hauv tsev kho mob rau txhawm kev mob plawv.

Nrog rau hyperlipidemia, Tovakard cov tshuaj tau qhia nyob rau hauv parallel nrog zaub mov noj uas txo cov ntsuas ntawm "tsis zoo" cov cholesterol thiab triglycerol thiab txhim kho HDL.

Tsis txhob muab tshuaj Torvacard rau cov kab mob siab ua haujlwm nyob rau ntu nquag thiab muaj siab rhiab rau cov khoom xyaw ntawm atorvastatin.

Thorvacard thaum cev xeeb tub

Cev xeeb tub, nrog rau cov poj niam uas tuaj yeem cev xeeb tub, tsis txhob siv Torvacard, vim tias cov statins yog qhov txaus ntshai rau tus me nyuam hauv plab. Cov neeg mob hnub nyoog yug menyuam yuav tsum muaj lub luag haujlwm xaiv tshuaj thaiv tsis pub muaj menyuam yaus.

Txawm hais tias cev xeeb tub ib txwm muaj, feem pua ​​ntawm cov roj (cholesterol) thiab triglycerol ntau dua li ib txwm. Hypolipidemic tshuaj nyob rau hauv cov ntaub ntawv no tsis muaj txiaj ntsig, vim tias cov roj cholesterol thiab nws cov lus qhia tsim nyog rau kev tsim tag nrho ntawm tus me nyuam hauv plab.

Atherosclerosis yog ib qho mob ntev thiab nws tau tsim kho rau ntau caum xyoo, yog li ntawd, lub sij hawm luv luv hlaus atorvastine yuav tsis cuam tshuam rau cov chav kawm ntawm hypercholesterolemia.

Rau Torvakard, kev tshawb fawb txog cov nyhuv ntawm cov tshuaj rau ib tug menyuam uas noj niam mis tseem tsis tau ua tiav. Tab sis feem ntau, cov statins tuaj yeem nkag rau hauv niam mis, ua rau muaj qhov tsis xav zoo nyob hauv menyuam mos. Yog li, nws raug nquahu rau cov poj niam siv Torvacard hloov chaw tus menyuam mus rau khoom noj khoom haus khoom neeg tsim.

Tsuas tshuaj thiab tswj hwm

Nrog hyperlipidemia thiab dyslipidemia, thawj koob tshuaj ntawm cov tshuaj Tovakard qhia pom zoo kom tsis pub dhau 10-20 mg / hnub. Yog tias cov roj (cholesterol) "tsis zoo" yuav tsum raug txo los ntawm 45% lossis ntau dua, koj tuaj yeem pib nrog 49 mg / hnub. Cov kev txwv dav dav ntawm cov ntau npaum li cas yog 10-80 mg / hnub.

Cov menyuam yaus 10-17 xyoo nrog kev mob heterozygous hypercholesterolemia pib qhov kev kawm nrog 10 mg / hnub. Qhov feem ntau cov cai ntawm Tovacar yog txog 20 mg / hnub. Tsis muaj cov ntaub ntawv hais txog kev cuam tshuam ntawm menyuam yaus rau kev txhaj tshuaj loj dua. Kho tus nqi them txhua 4 lub lis piam los yog ntau dua.

Yog tias muaj keeb kwm ntawm homozygous hypercholesterolemia, ntau npaum li cas ntawm Torvacard yog 10-80 mg / hnub. Statin siv nrog rau cov tshuaj lipid-txo qis, zoo li thaum tsis muaj kev kho mob li ntawd.

Dosage tshwj xeeb tsis tas yuav tsum muaj rau cov neeg mob lub raum tsis ua haujlwm, vim tias cov kev tawm tshiab no tsis cuam tshuam rau qhov zoo ntawm atorvastatin.

Cov lus qhia tsis pom zoo kom muab tshuaj Torvacard rau cov neeg mob uas siv HIV thiab kab mob siab C tiv thaiv kab mob siab, nrog rau cyclosporine.

Pab nrog overdose

Tsis muaj kev kho tshwj xeeb rau kev siv ntau dhau ntawm Torvacard. Cov hau kev yog xaiv nyob ntawm cov tsos mob, ntxiv los ntawm kev txhawb nqa. Vim tias muaj kev khi nrawm ntawm cov nquag tiv thaiv rau cov ntshav protein, ib qho yuav tsum tsis txhob cia siab tias muaj kev nce ntxiv hauv nws txoj kev tshem tawm los ntawm hemodialysis.

Txog Thoracard, cov lus qhia ntxaws ntxiv rau kev siv tuaj yeem pom ntawm no.

Sab sij huam

Soj ntsuam kev mob tshwm sim hauv 2% ntawm cov neeg mob noj ntau qhov sib txawv ntawm Torvacard, tsis hais qhov ua rau, raug nthuav tawm hauv lub rooj.

Atorvastatin tsis cuam tshuam rau theem ntawm kev saib xyuas thiab qhov tshuaj tiv thaiv thaum ua haujlwm nrog cov txheej txheem lossis tswj kev thauj khoom.

Torvacard - analogues

Cov tshuaj noj uas muaj cov yam ntxwv zoo sib xws yuav suav nrog atorvastatin lossis tsuas muaj cov haujlwm zoo sib xws ntawm lub cev. Ua ntej txiav txim siab yuav hloov mus rau lwm txoj hauv kev kho mob, koj yuav tsum sab laj koj tus kws kho mob tas li.

Rau cov nquag tivthaiv, koj tuaj yeem xaiv rau Torvakard analogues ntau kim thiab pheej yig dua hom:

• Cov Atomax
• Tus tub sab
• Atoris
• Liptonorm,
• Lipona
• Liprimara,
• Lipoford
• Tulipa.

Raws li cov txiaj ntsig ntawm cov nyhuv ntawm lub cev, Torvacard tuaj yeem hloov:

• Avestatin,
• Acortoy
• Apextatin,
• Aterostat,
• Vasilip,
• Zovatin,
• Zorstat
• Zokor,
• Cardiostatin
• Los ntawm tus ntoo khaub lig
• Leskol,
• Lovastatin
• Mertenil,
• Rosuvastatin,
• Roxeroi
• SimvaHexalom,
• Simlo
• Ib Sim Neej
• Simvakardom.

Ua ntej noj Torvacard lossis lwm yam tshuaj noj statin, nws yog ib qho tseem ceeb kom kawm cov lus qhia rau kev siv, kev daws qhov tshwm sim thiab kev sib raug zoo nrog cov tshuaj sib xyaw.