Nateglinide - cov lus piav qhia ntawm cov tshuaj, cov lus qhia rau kev siv, tshuaj xyuas
Qhov ncauj hypoglycemic tus neeg sawv cev, ib qho phenylalanine derivative. Hauv kev siv tshuaj thiab tshuaj muaj zog nws txawv ntawm lwm yam kab mob hypoglycemic. Nws rov qab tso cov tshuaj insulin thaum ntxov, uas ua rau kev txo qis ntawm cov piam thaj hauv cov ntshav hauv cov ntshav thiab qib glycated hemoglobin (HbA1c).
Nyob hauv kev cuam tshuam ntawm nateglinide noj ua ntej noj mov, thaum ntxov (lossis thawj) theem ntawm cov kua dej tso kua mis rov qab. Cov txheej txheem ntawm qhov tshwm sim no yog qhov nrawm thiab thim rov qab kev sib cuam tshuam ntawm nateglinide nrog K + ATP-dependent channel ntawm pancreatic β-hlwb. Xaiv ntawm nateglinide nrog kev hwm K + ATP-ywj pheej channel ntawm pancreatic cells-cell yog 300 npaug ntau dua qhov ntawd uas hais txog kev sib koom tes ntawm lub plawv thiab cov hlab ntsha.
Qeb tsis sib thooj, tsis zoo li lwm yam kev tiv thaiv kab mob hauv lub qhov ncauj, ua rau cov kua dej hauv thaj tsam thawj 15 feeb tom qab noj mov, vim tias cov kev cuam tshuam tom qab ("peaks") hauv cov ntshav qabzib concentration yog smoothed. Hauv 3-4 teev tom ntej no, cov tshuaj insulin rov qab los rau nws cov nqi qub, yog li, nws yog qhov ua tau kom tsis txhob muaj kev txhim kho ntawm postprandial hyperinsulinemia, uas tuaj yeem ua rau cov ntshav qab zib tsawg dua.
Kev zais ntawm insulin los ntawm pancreatic β-hlwb tshwm sim los ntawm nateglinide nyob ntawm theem ntawm cov piam thaj hauv cov ntshav, uas yog, vim tias cov concentration ntawm cov piam thaj txo, insulin secretion tsawg. Hloov siab, kev sib txig kev noj mov lossis kev ua txhaum ntawm cov dej qabzib ua rau cov kua dej hauv lub zais insulin ntau ntxiv.
Coj sab hauv. Nrog kev kho mob monotherapy - 120-180 mg 3 zaug / hnub. Thaum coj los kho ua ke - 60-120 mg 3 zaug / hnub.
Sab sij huam
Tejzaum nws: cov tsos mob xav tias yuav qhia txog kev txhim kho ntshav qab zib - nce tawm hws, tshee tshee, kiv taub hau, nce ntau, qab los, palpitations, xeev siab, tsis muaj zog, malaise (feem ntau cov xwm txheej no tau me thiab yooj yim nres los ntawm kev noj cov zaub mov carbohydrates).
Tsis tshua muaj: kev ua si ntawm hepatic enzymes hauv cov ntshav (feem ntau me thiab hloov), tawm pob, khaus, urticaria.
Hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) - nrog qhov tsis muaj txiaj ntsig ntawm kev kho kev noj haus thiab kev siv lub cev (hauv kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic).
Cov lus qhia tshwj xeeb
Txoj kev pheej hmoo ntawm kev txhim kho hypoglycemia thaum noj nateglinide (zoo li lwm yam tshuaj hypoglycemic) muaj ntau dua rau cov neeg mob laus uas txo lub cev hnyav, nyob rau hauv muaj adrenal lossis pituitary tsis txaus. Kev txo qis ntshav qabzib hauv lub ntsej muag tuaj yeem tshwm sim los ntawm kev haus dej haus cawv, ua kom lub cev muaj zog, nrog rau kev siv lwm cov tshuaj tiv thaiv ntshav qab zib hauv lub cev.
Kev siv cov beta-blockers ib txhij tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib.
Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab
Cov neeg mob ua haujlwm nrog kev siv tshuab thiab tsav tsheb yuav tsum ceev faj cov kev tiv thaiv kom tsis txhob mob ntshav qab zib.
Kev ntsuas rau siv
Nateglinide qhia tias yog monotherapy rau kev txo qis cov ntshav qabzib hauv cov neeg mob uas muaj ntshav qab zib hom 2 (ntshav qab zib tsis yog insulin-nyob rau hauv cov ntshav qab zib mellitus) uas tsis muaj zaub mov noj tsis txaus thiab tawm dag zog kom tswj tau lawv cov glycemia thiab uas tsis tau kho mob ntev ntev nrog rau lwm cov tshuaj tiv thaiv ntshav qab zib.
Nateglinide tseem qhia txog kev kho mob ua ke nrog metformin hauv cov neeg mob uas tsis txaus tswj glycemia tawm tsam keeb kwm ntawm metformin (nws tsis pom zoo kom hloov metformin nrog nateglinide).
Cov Tshuaj Hauv Tshuaj
Qhov ncauj hypoglycemic tus neeg sawv cev, ib qho phenylalanine derivative. Hauv kev siv tshuaj thiab tshuaj muaj zog nws txawv ntawm lwm yam kab mob hypoglycemic. Nws rov qab tso cov tshuaj insulin thaum ntxov, uas ua rau kev txo qis ntawm cov piam thaj hauv cov ntshav hauv cov ntshav thiab qib glycated hemoglobin (HbA1c).
Nyob hauv kev cuam tshuam ntawm nateglinide noj ua ntej noj mov, thaum ntxov (lossis thawj) theem ntawm cov kua dej tso kua mis rov qab. Cov txheej txheem ntawm qhov tshwm sim no yog qhov nrawm thiab thim rov qab kev sib cuam tshuam ntawm nateglinide nrog K + ATP-dependent channel ntawm pancreatic β-hlwb. Xaiv ntawm nateglinide nrog kev hwm K + ATP-ywj pheej channel ntawm pancreatic cells-cell yog 300 npaug ntau dua qhov ntawd uas hais txog kev sib koom tes ntawm lub plawv thiab cov hlab ntsha.
Qeb tsis sib thooj, tsis zoo li lwm yam kev tiv thaiv kab mob hauv lub qhov ncauj, ua rau cov kua dej hauv thaj tsam thawj 15 feeb tom qab noj mov, vim tias cov kev cuam tshuam tom qab ("peaks") hauv cov ntshav qabzib concentration yog smoothed. Hauv 3-4 teev tom ntej no, cov tshuaj insulin rov qab los rau nws cov nqi qub, yog li, nws yog qhov ua tau kom tsis txhob muaj kev txhim kho ntawm postprandial hyperinsulinemia, uas tuaj yeem ua rau cov ntshav qab zib tsawg dua.
Kev zais ntawm insulin los ntawm pancreatic β-hlwb tshwm sim los ntawm nateglinide nyob ntawm theem ntawm cov piam thaj hauv cov ntshav, uas yog, vim tias cov concentration ntawm cov piam thaj txo, insulin secretion tsawg. Hloov siab, kev sib txig kev noj mov lossis kev ua txhaum ntawm cov dej qabzib ua rau cov kua dej hauv lub zais insulin ntau ntxiv.
Cov Tshuaj Pharmacokinetics
Kev Tsis Txaus Siab Tom qab kev noj haus sai li sai tau ua ntej noj mov, nateglinide nrawm nrawm, Cmax hauv ntshav tau tiav hauv nruab nrab li 1 teev. Thaum nateglinide raug kho rau cov neeg mob ntshav qab zib hom 2 ntshav qab zib hauv 60 txog 240 mg 3 zaug hauv ib hnub rau 1 lub lis piam, kev cia siab ntawm ob qho tib si AUC thiab thiab Cmax los ntawm cov koob tshuaj. Tmax hauv cov neeg mob no tsis siv tshuaj ntau-vam khom. Kev Muaj Mob Raug Ncaj Ncees yog kwv yees li 73%. Thaum noj nrog lossis tom qab noj mov, qhov nqus ntawm nateglinide (AUC) tseem tsis tau hloov pauv, tab sis qhov kev txo qis ntawm qhov tso tawm kom tsawg tau pom, tus cwj pwm los ntawm kev txo qis hauv Cmax thiab ncua ntawm Tmax. Thaum noj nateglinide ntawm lub plab khoob, plasma concentration profiles yog tus cwj pwm los ntawm ntau lub pob zeb. Cov nyhuv no tsis pom thaum noj nateglinide ua ntej noj mov.
Kev xa Khoom. Raws li cov lus ceeb toom, nrog rau / hauv kev qhia txog nateglinide, qhov ntim ntawm kev faib tawm hauv qhov sib luag ntawm lub xeev hauv cov neeg muaj kev noj qab haus huv yog li 10 liv. Nateglinide khi rau 98% nrog cov ntshiab protein, feem ntau nrog albumin, kom tsawg dua - nrog α1-acid glycoprotein. Tus nqi ntawm khi rau plasma proteins tsis nyob ntawm qhov kev nyeem ntawm cov tshuaj hauv cov concentration ntawm 0.1 txog 10 μg / ml.
Kev zom zaub mov. Ua ntej nthuav tawm, nateglinide yog metabolized nrog kev koom nrog ntawm ntau qhov system oxidase. Lub ntsiab ntawm cov metabolic yog hydroxylation, tom qab khi rau glucuronide. Lub ntsiab metabolites muaj ntau yam tsis muaj zog nyob rau hauv cov nyhuv hypoglycemic dua li ntawm nateglinide. Lub cev me-metabolite - isoprene - zoo sib xws hauv lub zog rau cov khoom qub ntawm nateglinide. Raws li kev tshawb fawb hauv vitro, nateglinide yog qhov tseem ceeb metabolized nrog kev koom tes ntawm cytochrome P450: CYP2C9 isoenzyme (70%) thiab CYP3A4 (30%).
Chaw Sau Ntawv. Cov Cwj Pwm thiab nws cov metabolites tau nrawm thiab tiav tawm tom qab kev tswj hwm ntawm qhov ncauj. Hauv 6 teev, kwv yees li 75% ntawm kev txhaj tshuaj nateglinide uas muaj cov pa roj carbon 14C yog kuaj pom nyob hauv cov zis. 83% ntawm 14C-nateglinide raug nteg tawm los ntawm ob lub raum, 10% - los ntawm cov hnyuv. Kwv yees li 16% ntawm nateglinide lo cim nrog 14C yog txiav txim siab tsis hloov pauv ntawm cov zis. Hauv txhua qhov kev tshawb fawb hauv cov neeg ua haujlwm noj qab haus huv thiab nyob rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, kev saib xyuas ntawm nateglinide nyob rau hauv cov ntshav tau sai sai, qhov nruab nrab T1 / 2 lub sijhawm yog 1.5 teev. mg 3 zaug ib hnub rau 7 hnub.
Kev sib cuam tshuam nrog lwm yam tshuaj
Kev tshawb fawb hauv cov kab mob metabolism hauv lub cev tau pom tias nateglinide yog qhov feem ntau metabolized nrog kev koom tes ntawm cytochrome P450: CYP2C9 isoenzymes (70%) thiab, rau qhov tsawg dua, CYP3A4 (30%). Nateglinide yog ib yam muaj zog inhibitor ntawm CYP2C9 isoenzyme hauv vivo, uas tau qhia los ntawm nws lub peev xwm los inhibit hauv metabolism hauv vitro ntawm tolbutamide. Cov metabolism hauv cov teebmeem ntawm CYP3A4 inhibition tsis tau pom tias muaj nyob hauv kev sim tshuaj hauv vitro.
Gliburide. Hauv kev tshawb nrhiav, muaj ntau qhov kev kawm hla kev noj qab haus huv, cov neeg mob ntshav qab zib hom 2 tau raug sau nateglinide 120 mg 3 lub sij hawm txhua hnub ua ntej noj mov rau 1 hnub ua ke nrog 10 mg ntawm glyburide. Tsis muaj kev kuaj pom tseeb hauv kev hloov pauv ntawm cov chaw muag tshuaj ntawm ob qho tshuaj yeeb dej caw.
Metformin. Thaum kws kho mob rau cov neeg mob hom 2 mob ntshav qab zib mellitus nateglinide (120 mg) 3 zaug ib hnub ua ntej noj mov ua ke nrog cov tshuaj metformin 500 mg 3 zaug hauv ib hnub, tsis muaj kev kho mob pom tseeb hauv lub chaw muag tshuaj ntawm ob qho tshuaj.
Digoxin. Thaum 120 mg ntawm nateglinide tau raug tshaj tawm rau cov neeg tuaj yeem noj qab haus huv 3 zaug hauv ib hnub ua ntej noj mov, hauv kev sib xyaw nrog ib koob tshuaj 1 mg ntawm digoxin, tsis muaj kev kho mob pom tseeb hauv lub pharmacokinetics ntawm ob yam tshuaj.
Warfarin. Thaum cov neeg ua haujlwm noj qab haus huv tau raug hais kom muab 120 mg ntawm nateglinide 3 zaug ib hnub ua ntej noj mov rau 4 hnub ua ke nrog ib koob ntawm 30 mg ntawm warfarin rau hnub thib ob, tsis muaj kev hloov pauv hauv cov chaw muag tshuaj ntawm ob qho tshuaj, PV kuj tsis hloov pauv.
Diclofenac. Thaum sawv ntxov thiab yav tav su, 120 mg ntawm nateglinide ua ke nrog ib koob ntawm 75 mg ntawm diclofenac tsis ua rau muaj kev hloov tseem ceeb hauv cov chaw muag tshuaj ntawm ob qho tshuaj hauv cov neeg ua haujlwm noj qab haus huv.
Feem ntau ntawm nateglinide (98%) yog muaj zog khi rau cov ntshav plasma protein, feem ntau mus rau albumin. Hauv kev tshawb nrhiav hauv vitro ntawm kev txav chaw nrog cov tshuaj muaj qhov siab ntawm kev sib khi, xws li furosemide, propranolol, captopril, nicardipine, pravastatin, glyburide, warfarin, phenytoin, acetylsalicylic acid, tolbutamide thiab metformin, qhia tsis muaj kev cuam tshuam ntawm qhov ntim ntawm kev khi ntawm nateglinide rau plasma proteins. Nateglinide kuj tsis cuam tshuam rau plasma protein khi ntawm propranolol, glyburide, nicardipine, phenytoin, acetylsalicylic acid thiab tolbutamide hauv vitro. Txawm li cas los xij, hauv kev mob kho mob me me kev hloov pauv tau.
Qee cov tshuaj, suav nrog NSAIDs, salicylates, MAO inhibitors thiab tsis xaiv-beta-blockers tuaj yeem txhim kho cov nyhuv hypoglycemic ntawm nateglinide thiab lwm yam kab mob hypoglycemic.
Qee cov tshuaj, suav nrog thiazide diuretics, corticosteroids, cov thyroid hormone analogues, sympathomimetics, tuaj yeem txo cov nyhuv hypoglycemic ntawm nateglinide thiab lwm tus neeg lub qhov ncauj hypoglycemic. Thaum cov tshuaj no tau sau tseg los yog tso tseg hauv tus neeg mob uas tau txais nateglinide, nws yog qhov tsim nyog los soj ntsuam txog qib ntawm glycemia.
Kev sib txuam khoom noj khoom haus. Cov tshuaj pharmacokinetics ntawm nateglinide tsis yog nyob ntawm qhov sib xyaw ua ke ntawm cov zaub mov (protein, rog lossis carbon cov ntsiab lus). Txawm li cas los xij, Cmax yog qhov txo qis dua thaum noj nateglinide 10 feeb ua ntej noj zaub mov ua kua. Nateglinide tsis muaj kev cuam tshuam dab tsi ntawm lub plab khoob hauv cov neeg noj qab haus huv, raws li qhia los ntawm kev kuaj pom acetaminophen.
Cov kev ceev faj rau kev siv
Kev ntshav siab. Txhua tus neeg sawv cev hauv qhov ncauj hypoglycemic tuaj yeem ua rau hypoglycemia. Qhov tuab ntawm cov ntshav qog ntshav nce raws qhov mob hnyav ntawm cov ntshav qab zib, kev tswj ntawm glycemia thiab lwm yam ntxwv ntawm tus neeg mob. Cov neeg laus thiab cov neeg laus, cov neeg mob tsis zoo, cov neeg mob adrenal lossis qias neeg tsis muaj peev xwm ua rau cov ntshav hypoglycemic los ntawm txoj kev kho no. Txoj kev pheej hmoo ntawm cov ntshav qog ntshav qab zib tuaj yeem nce ntxiv nrog lub zog ua rau lub cev, haus dej cawv, nrog kev noj zaub mov kom tsis txaus (ua kom ntev lossis ua yuam kev), lossis thaum sib xyaw nrog lwm tus neeg lub qhov ncauj hypoglycemic. Tej zaum nws yuav nyuaj rau tshawb pom ntshav qog ntshav nyob rau hauv cov neeg mob autonomic (visceral) neuropathy thiab / lossis thaum noj beta-blockers. Yuav kom txo qhov kev pheej hmoo ntawm cov ntshav siab ntshav qab zib, nateglinide raug tso cai ua ntej noj mov, tus neeg mob uas yoo mov noj zaub mov tseem yuav tsum hla qhov tom ntej.
Ua rau daim siab. Nawb kev pab cuam yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj mob hnyav los yog mob siab daim siab, vim nws siv rau hauv cov neeg mob zoo li no tseem tsis tau raug tshawb nrhiav.
Poob ntawm glycemic tswj. Sij hawm hloov glycemic tswj tuaj yeem tshwm sim nrog kev kub taub hau, mob, raug mob, thiab phais. Hauv cov rooj plaub no, es tsis txhob siv nateglinide, kev kho tshuaj insulin yog qhov tsim nyog. Qhov tsis txaus ntseeg thib ob lossis txo qis ntawm qhov ua tau zoo ntawm nateglinide tej zaum yuav tshwm sim tom qab qee lub sijhawm.
Kev kuaj sim. Cov lus teb rau kev kho yuav tsum raug soj ntsuam los ntawm cov piam thaj thiab qib HbA1c.
Qhia txog ntawm cov tshuaj
Kev Tshawb Fawb - Tus neeg sawv cev qhov ncauj ntshav hypoglycemic, tus phenylalanine derivative. Hauv kev siv tshuaj thiab tshuaj muaj zog nws txawv ntawm lwm yam kab mob hypoglycemic. Rov qab tso cov tshuaj insulin thaum ntxov, uas ua rau kev txo qis ntawm cov piam thaj hauv qabzib hauv cov ntshav thiab qib ntawm glycated hemoglobin (HbA 1c).
Nyob hauv kev cuam tshuam ntawm nateglinide noj ua ntej noj mov, thaum ntxov (lossis thawj) theem ntawm cov kua dej tso kua mis rov qab. Cov txheej txheem ntawm qhov tshwm sim no yog qhov nrawm thiab thim rov qab kev sib cuam tshuam ntawm nateglinide nrog K + ATP-dependent channel ntawm pancreatic β-hlwb. Xaiv ntawm nateglinide nrog kev hwm K + ATP-ywj pheej channel ntawm pancreatic cells-cell yog 300 npaug ntau dua qhov ntawd uas hais txog kev sib koom tes ntawm lub plawv thiab cov hlab ntsha.
Qeb tsis sib thooj, tsis zoo li lwm yam kev tiv thaiv kab mob hauv lub qhov ncauj, ua rau cov kua dej hauv thaj tsam thawj 15 feeb tom qab noj mov, vim tias cov kev cuam tshuam tom qab ("peaks") hauv cov ntshav qabzib concentration yog smoothed. Hauv 3-4 teev tom ntej no, cov tshuaj insulin rov qab los rau nws cov nqi qub, yog li, nws yog qhov ua tau kom tsis txhob muaj kev txhim kho ntawm postprandial hyperinsulinemia, uas tuaj yeem ua rau cov ntshav qab zib tsawg dua.
Kev zais ntawm insulin los ntawm pancreatic β-hlwb tshwm sim los ntawm nateglinide nyob ntawm theem ntawm cov piam thaj hauv cov ntshav, uas yog, vim tias cov concentration ntawm cov piam thaj txo, insulin secretion tsawg. Hloov siab, kev sib txig kev noj mov lossis kev ua txhaum ntawm cov dej qabzib ua rau cov kua dej hauv lub zais insulin ntau ntxiv.
Sau cov analogues
| Daim ntawv tso tawm (los ntawm qhov nrov) | Nqe, tshiav. |
| Kev Tshawb Fawb | |
| Qeb Dhau Nawb * (Pawg (* Pawg)) | |
| Starlix | |
Ib tus qhua qhua tshaj tawm hnub tas sijhawm
Ntev npaum li cas nws yuav siv sij hawm noj Nateglinide xav tias qhov kev txhim kho hauv tus neeg mob lub sijhawm?Cov neeg tuaj koom kev soj ntsuam feem ntau tom qab 1 hnub hnov qhov kev txhim kho. Tab sis qhov no yuav tsis raug rau lub sijhawm uas koj yuav txhim kho. Nrog koj tus kws kho mob xav ntev li cas koj yuav tsum tau noj cov tshuaj no. Cov lus hauv qab no qhia cov kev tshwm sim ntawm kev tshawb fawb txog kev pib ua haujlwm zoo.
| Cov Tswv Cuab | % | ||||||
|---|---|---|---|---|---|---|---|
| 1 hnub | 1 | Peb tus qhua tuaj yeem tshaj tawm lub hnub nyoog mob
| 33.3% | ||||
| 30-45 xyoo | 1 | 33.3% | |||||
| > 60 xyoo lawm | 1 | Cov khoom txaus nyiamYuav ua li cas xaiv txoj cai piv rau Qhov sib txawv ntawm cov kis thiab kab mob Kev ua xua yog qhov ua rau mob khaub thuas Txoj hlab zis: kho mob chlamydial urethritis Kev taw qhia thiab contraindications rau siv, overdose
Cov tshuaj muaj peev xwm siv tau ob qho tib si thaum kho monotherapy thiab raws li kev tivthaiv hauv txoj hauv kev kho mob hauv kev kho mob ntshav qab zib hom 2. Feem ntau cov tshuaj feem ntau, cov tshuaj siv ua ke nrog nrog Metformin. Thaum siv tshuaj, muaj ntau tus lej contraindications rau nws siv. Lub ntsiab ntawm cov kev tsis sib haum xeeb rau kev siv Nateglinide yog cov hauv qab no:
Raws li cov txheej txheem ntawm cov txiaj ntsig ntawm cov tshuaj ntawm lub cev, nws tuaj yeem xav tias qhov tseem ceeb ntawm kev ua txhaum ntawm kev pom zoo ntau npaum li cas hauv kev kho mob ntshav qab zib yog qhov kev txhim kho ntawm hypoglycemia hauv tus neeg mob, uas tuaj yeem pom nws tus kheej hauv qib sib txawv ntawm qhov ntau nyob ntawm qhov ntau dhau ntawm kev kho mob thaum kho. Cov kev xaiv ntawm txoj kev rau kev kho cov tsos mob overdose yog nyob ntawm qhov ntau ntawm kev ua kom pom. Thaum tswj hwm tus neeg mob kom nco qab thiab qhov tsis pom tus neeg mob hlwb, nws raug nquahu kom muab cov piam thaj hauv dej qab zib sab hauv thiab kho cov khoom noj kom tsawg. Nrog rau kev txhim kho ntawm daim ntawv hnyav ntawm hypoglycemic lub xeev, nyob rau hauv uas muaj kev txhim kho ntawm lub xeev ntuav thiab qaug dab peg, nws raug nquahu kom nqa tawm cov tshuaj ua kua qab zib.
Cov lus qhia rau kev siv tshuaj
Nyob rau hauv cov ntaub ntawv ntawm monotherapy, ib tug tshuaj ntawm 120-180 mg peb zaug ib hnub twg yog kws kho. Yog tias Nateglinide siv los ua ib qho ntawm cov khoom siv ntawm cov kev kho mob nyuaj, kev pom zoo kom noj tshuaj thaum kho yog los ntawm 60 txog 120 mg peb zaug ib hnub. Thaum siv cov tshuaj, tus neeg mob tuaj yeem txhim kho qee yam tshwm sim hauv lub cev. Cov kev mob tshwm sim thaum noj cov tshuaj tau tshwm sim hauv kev ua haujlwm tsis zoo ntawm cov kab ke hauv qab no thiab cov kabmob ntawm lub cev ntawm tus neeg mob:
Tsis tas li ntawd, cov kev mob tshwm sim tuaj yeem tshwm sim uas cuam tshuam cov mob ntawm lub cev. Yog tias muaj cov kev ntxhov siab hauv kev ua haujlwm ntawm lub paj hlwb, tus neeg mob tau hnov zoo li kiv taub hau. Kev ua tsis zoo ntawm lub ntsws ua kom pom tseeb los ntawm kev tshwm sim ntawm kev ua pa ntawm tus neeg mob, kev txhim kho cov cim ntawm mob ntsws, thiab qhov tshwm sim ntawm hnoos. Thaum muaj kev phiv los cuam tshuam rau kev ua haujlwm ntawm lub plab zom mov, tus neeg mob tau tshwm sim ua kom raws plab thiab zoo nkaus li xeev siab. Cov kev mob tshwm sim tseem ceeb ntawm kev cuam tshuam ntawm metabolic yog txoj kev loj hlob ntawm lub xeev hypoglycemic nyob rau hauv tus neeg mob lub cev, thiab ntawm cov mob hnyav ntawm glycemic coma. Txoj kev loj hlob ntawm lub xeev hypoglycemic nrog kev siv Nateglinide thaum kho yog tsis tshua muaj. Xeev siab thiab zawv plab yog cov kev mob tshwm sim los ntawm kev noj tshuaj kuj tshwm sim tsis tshua pom tshwm sim, feem ntau cov kev mob tshwm sim ntawm tus neeg no thaum siv txoj kev kho mob ntshav qab zib hom 2 yog tias Metformin yog ib qho ntawm cov kev kho. Qee zaum, thaum noj Netelinid nyob rau hauv tus neeg mob ntshav qab zib mellitus, qhov tshwm sim ntawm qhov mob ntawm mob txha nraub qaum yog pom tias yog kev mob tshwm sim.
Kev ntsuas ntawm cov tshuaj, cia thiab nqi ntawm cov tshuaj
Lub txee lub neej ntawm cov tshuaj yog ob xyoos. Tom qab tas sijhawm ntawm lub sijhawm cia, cov tshuaj yog txwv tsis pub siv rau kev kho mob. Cov khoom tas sij hawm yuav tsum tau ua dua tshiab. Qhov chaw khaws cia ntawm cov tshuaj yuav tsum tsis pub nkag mus rau me nyuam. Cov tshuaj uas nrov tshaj plaws uas muaj cov nyhuv zoo sib xws yog cov hauv qab no:
Feem ntau ntawm cov neeg mob uas tau siv Natelitid hauv chav kawm ntawm txoj kev kho kom tawm mus xyuas qhov zoo ntawm cov tshuaj. Lub xub ntiag ntawm kev xav tsis zoo txog cov tshuaj feem ntau muaj feem xyuam nrog kev noj tshuaj tsis zoo. Cov tshuaj muaj peev xwm yuav tau ntawm chaw muag tshuaj los ntawm cov tshuaj noj. Tus nqi ntawm ib cov tshuaj hauv Lavxias Federation feem ntau nyob ntawm thaj av uas qhov muag tshuaj muag. Tus nqi ntawm ib cov tshuaj hauv Lavxias teb sab, nyob ntawm thaj av ntawd, tuaj yeem nyob ntawm 6300 txog 10500 rubles rau ib pob. Cov tshuaj dab tsi tuaj yeem siv hauv kev kho mob ntshav qab zib yuav qhia cov yees duab hauv tsab xov xwm no.
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