NovoMix® 30 FlexPen®: xyuas > Cov tshuaj insulin

Lub vev xaib raug cai ntawm lub tuam txhab RLS ®. Lub encyclopedia tseem ceeb ntawm cov tshuaj thiab cov khoom muag ntawm cov khw muag tshuaj assortment ntawm Lavxias Internet. Daim ntawv teev cov tshuaj Rlsnet.ru muab cov neeg siv kev nkag mus rau cov lus qhia, tus nqi thiab cov lus piav qhia txog tshuaj, khoom noj khoom haus, khoom siv kho mob, khoom siv kho mob thiab lwm yam khoom lag luam. Daim ntawv qhia pharmacological suav nrog cov ntaub ntawv ntawm kev sib xyaw thiab daim ntawv tso tawm, kev nqis tes ua pharmacological, kev taw qhia rau kev siv, contraindications, kev phiv tshuaj, kev cuam tshuam tshuaj, hom kev siv tshuaj, cov tuam txhab tshuaj. Daim ntawv qhia cov tshuaj muaj nqi rau tshuaj thiab cov khoom lag luam tshuaj hauv Moscow thiab lwm lub nroog Lavxias.

Nws yog txwv tsis pub xa, theej, tshaj tawm cov ntaub ntawv yam tsis tau txais kev tso cai los ntawm RLS-Patent LLC.
Thaum hais cov ntaub ntawv xov xwm luam tawm nyob rau ntawm nplooj ntawv ntawm lub xaib www.rlsnet.ru, qhov txuas mus rau qhov chaw ntawm cov ntaub ntawv xav tau.

Ntau ntau yam nthuav

Qoob loo.

Kev ua lag luam siv cov ntaub ntawv tsis raug tso cai.

Cov ntaub ntawv yog npaj rau cov kws kho mob.

Yam khoom sib xws

Dioxidine Ntshav Qab Zib muaj ntshav qab zib

Kev Siv Tshuaj Yeeb: cov lus qhia rau kev siv

Yuav kho tus mob ntshav qab zib li cas nrog Tiogamma?

Lub hauv paus ntsiab lus ntawm cov tshuaj Novomix

Cov tshuaj nkag mus rau hauv cov khw muag tshuaj hauv lub thawv tshuaj lossis lub thauv ntim tshwj xeeb. Qhov ntim ntawm ob daim ntawv tsuas yog 3 ml. Lub tshem tawm muaj 2 ntu.

Thaum noj, cov tshuaj:

Cuam tshuam insulin receptors,
Nws inhibits qhov hnyav ntawm qab zib,
Txo cov ntshav qab zib
Normalizes qib ntawm cov piam thaj, uas nce siab sai tom qab noj mov.

Cov tshuaj tsis cuam tshuam rau kev muaj peev xwm muaj menyuam thiab tsis coj mus rau kev txhim kho kev sib hloov thiab cov qog ntshav hlav. Novomix yog cov tshuaj muaj kev nyab xeeb uas tsis tshua muaj kev mob tshwm sim thaum siv raug.

Cov tshuaj hormones, uas yog lub hauv paus ntawm cov tshuaj, zoo ib yam li insulin thiab yog li tsis ua rau muaj kev hem thawj rau lub cev.

Cov txheej txheem sib xyaw, siv thaum nqa khoom thiab pub mis rau menyuam

Cov tshuaj yog contraindicated nyob rau hauv kev txiav txim siab ntawm hypersensitivity rau insulin aspart los yog rau lub koom haum pab. Cov tshuaj tsis pom zoo rau cov menyuam yaus hnub nyoog qis dua 6 xyoo. Thaum nqa menyuam yaus, Novomix yog cov tshuaj pov thawj tsuas yog thaum muaj peev xwm muaj txiaj ntsig zoo tshaj qhov txaus ntshai rau tus menyuam hauv plab.

Thaum nqa tus menyuam, ua tib zoo saib xyuas qib ntawm cov piam thaj hauv cov ntshav thiab saib xyuas nws tas li. Hauv thawj peb lub hlis thaum cev xeeb tub, xav tau insulin yog qhov tsis lees paub, nyob rau lub sijhawm thib 2 thiab 3 lub hlis muaj ntau ntxiv. Tom qab yug menyuam, qhov tshuaj yuav txo tau, txij li lub cev xav tau cov tshuaj insulin poob qis.

Teeb meem tshwm sim tuaj

Nrog rau kev siv tsis raug lossis siv sijhawm ntev, Novomix tuaj yeem cuam tshuam rau tus neeg mob lub cev. Cov neeg mob qhia qhov mob tsis zoo:

Kev ntshav siab. Qhov no yog qhov xwm txheej thaum cov ntshav qab zib kom qis mus rau cov kab mob pathological (tsawg dua 3.3 mmol ib 1 liter). Kev mob ntshav qab zib kom nce qis hauv cov neeg mob uas tau muab tshuaj ntau dhau heev. Cov tsos mob uas muaj suab thaj tsawg tshwm sim sai. Cov tawv nqaij ua daj ntseg, ib tus neeg tawm hws txhua lub sijhawm, maj mam nkees thiab raug kev txom nyem los ntawm kev ntxhov siab ntxiv. Cov neeg mob uas muaj suab thaj qis hauv txhais tes tuav ntawm tes, poob lub zog thiab ua kom tsis meej pem. Cov ntsiab lus ntawm kev saib xyuas yog qhov tsis pom, lub siab lub ntsws yuav nrawm thiab tsaug zog tas li. Feem ntau, cov neeg mob hypoglycemia muaj kev tshaib tsis nqhis. Lub zeem muag pom kev tsis zoo thiab qhov tsis zoo siab tshwm sim. Hauv kev muaj ntshav ntau ntau ntawm cov ntshav qab zib hauv lub cev, tus neeg mob txhim kho ua mob nkees thiab cuam tshuam ntawm lub hlwb. Yog tias tsis muaj kev pabcuam tsis sijhawm, txo lub qog ntshav ua rau tus neeg mob tuag,

Cov kev mob tshwm sim ntxiv - pom kev cuam tshuam cuam tshuam nrog cov nqaij hauv lub cev ntau ntxiv, mob ntshav qab zib ua kom rov zoo dua, mob hlab ntsha hlwb, mob ntawm qhov chaw txhaj tshuaj.

Novomiks: kev thov kev qhia

Ua ntej siv cov khoom, lob lub taub hau los yog cov cwj mem pov tseg thiab co. Them sai sai rau cov xim ntawm lub thawv ntim - qhov ntxoov ntxoo yuav tsum zoo ib yam thiab dawb. Cov luas tau txuas rau ntawm phab ntsa ntawm daim cartridge yuav tsum tsis txhob. Tsuas pub siv ib rab koob pub xwb - yog tias koj tsis saib xyuas txoj cai no, ces koj muaj kev pheej hmoo kis mob.

Ua ntej siv, nws yog ib qho tseem ceeb kom soj ntsuam cov qauv pib thiab kev ceev faj:

Tsis txhob siv cov tshuaj yog tias ua ntej nws tau dag hauv lub tub yees,
Yog tias tus neeg mob pom tau tias cov piam thaj hauv qab qis, nws yog txwv tsis pub siv tshuaj. Yuav kom nce qabzib, txaus
Noj cov khoom noj uas muaj carbohydrates yooj yim (xws li khaub noom qab zib)

Tsis txhob hnov qab txog kev soj qab xyuas cov qib qab zib kom tsis tu ncua. Ua raws cov lus qhia tiv thaiv cov mob hnyav thiab txo cov piam thaj hauv qab.

Sib xyaw nrog lwm yam tshuaj

Thaum xam xyuas qhov ntau npaum li cas, xav txog tias qee cov tshuaj muaj peev xwm cuam tshuam cov metabolism hauv kev rog. Cov tshuaj no suav nrog:

tshuaj uas ua rau muaj suab thaj txo tsawg,

Okreotide
MAO inhibitors,
Cov ntsev,
Anabolics
Sulfonamides,
Cov khoom muaj dej cawv.

Ib qho ntxiv, ib pawg ntawm cov tshuaj sawv tawm nyob rau hauv uas qhov kev xav tau Novomix 30 FlexPen nce. Cov pawg no suav nrog: cov thyroid hormones, cov tshuaj tswj kom tsis txhob muaj menyuam, danazole, thiazides, HSCs.

Qhov cuam tshuam rau kev tsav tsheb muaj peev xwm

Feem ntau cov kev mob tshwm sim thaum lub sij hawm kho yog qhov muag qab zib kom tsawg rau qhov tseem ceeb txaus ntshai. Ib qho ntawm cov tsos mob ntawm tus mob hypoglycemia yog qhov kev ua txhaum ntawm lub siab, vim qhov ntawd tus neeg mob yuav tsis tuaj yeem tsav lub tshuab lossis tsav lub tsheb tsis muaj kev pheej hmoo.

Tom qab kev coj ua, xyuas kom meej tias yuav tsis muaj kev phom sij ntawm cov piam thaj nce ntxiv. Yog tias cov tsos mob ntawm kev mob ntshav qab zib yog xyaum tsis tau, nws tsis pom zoo kom tsav tsheb, vim tias cov piam thaj tuaj yeem poob thaum twg los tau.

Koob tshuaj thiab kho kom haum

Novomix yog cov tshuaj kho tus mob monotherapy lossis hauv kev sib txuas nrog lwm yam tshuaj. Dosage nyob ntawm tus tib neeg cov yam ntxwv thiab hom kab mob:

Ntawm cov ntshav qab zib ntawm yam thib ob, cov tshuaj thawj zaug yog 6 units ua ntej noj thawj zaug thiab muaj tib chav ua ntej noj hmo. Nrog kev nce ntxiv rau cov insulin, qhov koob tshuaj tau hloov kho rau 12 units,
Yog tias tus neeg mob hloov kho nrog biphasic insulin rau Novomix, kev noj tshuaj thaum pib tseem yog li qub nrog rau kev coj ua yav dhau los. Ntxiv mus, cov koob tshuaj tau hloov pauv raws li qhov tsim nyog. Thaum pauv tus neeg mob mus rau cov tshuaj tshiab, yuav tsum ua tib zoo saib xyuas los ntawm tus kws kho mob kom ua,
Yog tias kev kho mob xav tau dag zog, tus neeg mob tau muab tshuaj rau ob npaug ntawm cov tshuaj,
Txhawm rau hloov pauv qhov ntsuas, ntsuas koj cov piam thaj ntawm 3 hnub dhau los. Yog tias nyob rau lub sijhawm no tau pom zoo txo cov piam thaj ntau, qhov koob tshuaj tsis tau ua kom zoo dua.

Cov koob tshuaj tau hloov kho tsis ntau tshaj ib zaug ib lub lim tiam. Koj tuaj yeem tau txais kev paub txog cov lus pom zoo rau kev muab tshuaj kho rau hauv cov lus qhia ntawm cov ntawv txuas nrog hauv pob.

Yuav siv cov tshuaj insulin li cas

Txoj kev sib xyaw ua ke ntawm txoj kev xaiv raug raug thiab nws cov lus taw qhia raug rau hauv lub cev yog txoj cai tseem ceeb ntawm kev ua tiav kev kho mob ntshav qab zib mellitus:

Ua ntej siv txoj kev daws teeb meem, tuav nws li 1-2 teev ntawm qhov kub ntawm 15-20 degrees. Tom qab ntawd muab lub taub hau yob thiab ntxeev nws ua ntej. Nres lub taub ntim ntawm koj lub xib teg, thiab tom qab ntawd muab koj ob txhais tes sib tov txhais tau hais tias koj tau dov ib tus pas lossis lwm yam khoom uas yog cylindrical. Rov qab siv li 15 zaug.
Tig lub pob hauv qab tav toj thiab co nws kom cov pob hauv lub khob yob los ntawm ib kawg mus rau lwm qhov.
Rov ua cov kauj ruam 1 thiab 2 kom txog thaum cov ntsiab lus ntawm lub thauv zoo nkauj thiab ua kom dawb.
Maj mam txhaj rau hauv cov roj subcutaneous. Tsis txhob txhaj cov ntsiab lus ntawm daim cartridge rau hauv txoj hlab ntshav - qhov no yuav ua rau cov ntshav qab zib nce siab.
Yog tias tsawg dua 12 PIECES ntawm cov tshuaj nyob hauv lub thawv, siv ib qho tshuaj tshiab kom sib tov ntau tusyees.

Tuav lub khawm pib kom txog thaum tag nrho cov tshuaj ntawm cov tshuaj raug txhaj hauv qab daim tawv nqaij. Yog tias koj siv 2 yam khoom sib txawv, tsis txhob sib tov lawv hauv ib lub thawv.

Yuav tsum nqa cov twj txhaj tshuaj nrog koj mus yog tias qhov qub siv tsis tau.

Thawj qhov kev pabcuam rau haus luam yeeb ntau dhau

Lub cim tseem ceeb ntawm kev noj ntau tshaj ntawm Novomix yog muaj ntshav qab zib tsawg. Ib tug neeg mob hauv tus mob no tuaj yeem pab tau ntau txoj kev:

Nrog nce me ntsis hauv qab zib, muab rau tus neeg mob yam khoom uas muaj cov carbohydrates yooj yim. Qhov no suav nrog confectionery: khaub noom, chocolate, thiab lwm yam. Nqa cov khoom qab zib nrog cov ntsiab lus qab zib txhua lub sijhawm - qhov xav tau nce lub siab ntxiv ntawm cov piam thaj tuaj yeem tshwm sim thaum twg los tau,
Mob ntshav qab zib tsawg yog kho nrog glucagon daws teeb meem. Cov tshuaj no nyob rau hauv ib qho nyiaj ntawm 0.5-1 mg. txhaj cov roj intramuscularly lossis subcutaneous rog,
Lwm txoj hauv kev rau glucagon yog kev daws teeb meem dextrose. Nws raug qhia nyob rau hauv cov mob hnyav, thaum tus neeg mob twb tau txhaj tshuaj nrog glucagon, tab sis nws tsis rov qab nco qab ntev dua 10 feeb. Dextrose yog muab tshuaj pleev ib leeg. Tsuas yog tus neeg tau kawm los yog kws kho mob tshwj xeeb tuaj yeem ua qhov no.

Txhawm rau tiv thaiv qab zib kom ntog dua, noj cov khoom noj nplua nuj nyob hauv cov khoom noj yooj yim thiab cov carbohydrates. Tsis txhob hnov qab txog kev ceev faj - noj hauv qee qhov me me thiaj li ua kom tsis txhob mob tawv nqaij.

Cov npe kev lag luam, nqi, chaw cia khoom

Cov tshuaj mus rau hauv cov khw muag tshuaj muaj ntau lub npe lag luam tawm. Txhua ntawm lawv yog tsim nyob rau hauv ib qhov ntim thiab kev ua kom pom tseeb ntawm cov tshuaj nquag.

Tus nqi nws txawv me ntsis:

Novomiks FlexPen - 1500-1700 rubles,
Novomiks 30 Penfill - 1590 rubles,
Cov tshuaj Insulin Aspart - 600 rubles (rau ib qho xaum-xaum hluav taws xob).

Cov tshuaj raug pom zoo kom khaws cia ntawm qhov kub tsis tshaj 25 degrees hauv qhov chaw tsaus ntuj uas tsis muaj peev xwm ua tau rau menyuam yaus.

Yog tias cov khoom tsis haum koj lossis tsis yog lub cev tiv thaiv lub cev vim los ntawm cov khoom siv pabcuam, peb xav kom koj paub koj tus kheej nrog cov pov thawj analogues:

Novomix 30 Penfill. Qhov no yog ob-tshooj tshuaj insulin-raws li tshuaj aspart. Nws ua ke cov tshuaj hormones uas ua rau lub sijhawm luv thiab ntev. Nws txhawb kev tsim cov khoom tseem ceeb, nce kev txav ntawm cov piam thaj ntawm qib ntawm tes thiab nws lub peev xwm tau nqus los ntawm lwm cov ntaub so ntswg. Nws cuam tshuam rau daim siab, txo cov piam thaj hauv ntau lawm thiab normalizes nws cov concentration hauv cov ntshav. Tsis zoo li hom Novomix, nws tseem siv tau yam tsawg 24 teev. Cov qauv ntawm cov tshuaj nquag hloov ua ke nrog ntuj insulin, yog li cov cuab yeej muaj kev nyab xeeb rau lub cev. Nrog rau kev siv raug, cov tshuaj siv ua rau yeej tsis ua rau muaj qhov tsis txaus siab xav tau. Contraindicated nyob rau hauv lub hnub nyoog ntawm 18 xyoo, nrog hypoklycemia thiab hypersensitivity,
Novomix 30 FlexPen. Nws cuam tshuam rau tsim cov tshuaj insulin thiab txhawb cov txheej txheem uas tshwm sim sab hauv lub hlwb. Lub sijhawm tiv thaiv nyob ntawm thaj chaw ntawm kev txhaj tshuaj, kev qoj ib ce, ntau npaum li cas thiab lwm yam. Cov tshuaj raug txwv rau kev kho mob ntawm hom 1 thiab hom 2 ntshav qab zib,
Novomix 50 FlexPen. Cov cuab yeej no yuav luag zoo sib xws rau ob yam tshuaj tau piav saum toj no. Qhov sib txawv tsuas yog nyob rau hauv kev saib xyuas ntawm cov tshuaj nquag. Vim li no, koj yuav tsum tau sab laj nrog kws kho mob ua ntej pib txoj kev kho mob.

Thaum xaiv txoj cai tshuaj, xav tsis tas tus nqi, tab sis kuj tseem muaj lwm cov ntsiab lus tseem ceeb. Qhov no suav nrog hom tshuaj insulin, cov xeeb ceem ntawm koj lub cev, kev nkag siab ntawm cov tshuaj thiab kab mob cuam tshuam.

Tsuas tshuaj thiab tswj hwm

Raug tshem tawm rau kev txhaj tshuaj subcutaneous. Cov tshuaj tiv thaiv yog hypoglycemia, kev tiv thaiv tsis txaus.

Rosinsulin C yog muab tshuaj subcutaneously 1-2 zaug hauv ib hnub, txog ib nrab ib teev ua ntej noj mov. Txhua zaus, qhov chaw txhaj tshuaj yuav tsum tau hloov. Hauv qee kis, tus kws endocrinologist tuaj yeem sau ntawv rau tus neeg mob txhaj tshuaj ntawm cov tshuaj.

Ua tib zoo mloog! Kev tswjhwm ntawm insulin ntawm ib nrab sijhawm yog txwv! Hauv txhua kis, tus kws kho mob ib leeg xaiv cov koob tshuaj, uas yuav yog nyob ntawm cov yam ntxwv ntawm chav kawm ntawm tus kab mob thiab cov ntsiab lus ntawm cov piam thaj hauv cov ntshav thiab zis.

Cov koob tshuaj li niaj zaus yog 8-24 IU, uas muab 1 zaug nyob rau ib hnub, rau qhov no koj tuaj yeem siv insulin koob txhaj nrog tshem tawm. Hauv cov menyuam yaus thiab cov neeg laus uas muaj lub siab xav mus rau qhov tsis txaus, qhov koob tshuaj tuaj yeem txo mus rau 8 IU ib hnub thiab, hloov pauv, hauv cov neeg mob uas txo qis qhov rhiab siab - nce ntxiv rau 24 IU ib hnub lossis ntau dua.

Yog tias qhov koob tshuaj txhua hnub ntau dua li 0.6 IU / kg, nws raug tswj hwm 2 zaug hauv ib hnub nyob rau ntau qhov chaw. Yog tias cov tshuaj tau muab tshuaj tso rau hauv ib qho ntawm 100 IU ib hnub lossis ntau dua, tus neeg mob yuav tsum tau pw hauv tsev kho mob. Qhov kev hloov ntawm ib qho tshuaj insulin mus rau lwm qhov yuav tsum tau ua nyob ntawm kev saib xyuas ntawm kws kho mob.

Cov tshuaj yog hais txog cov tshuaj insulins nruab nrab, uas tau qhia:

kom txo ntshav ntshav qab zib
kom nce nqus ntawm cov piam thaj los ntawm cov ntaub so ntswg,
lug txhim khu glycogenogenesis thiab lipogenesis,
kom txo tus nqi ntawm cov piam thaj tso tawm los ntawm daim siab,
rau cov synthesis protein.

angioedema,
txog siav
urticaria
txo hauv cov ntshav siab,
npaws.

tawm hws zoo,
pallor ntawm daim tawv nqaij,
kev tshaib kev nqhis
lub plawv dhia
ntxhov siab
hws
kev zoo siab
tshee hnyo
paresthesia nyob rau hauv lub qhov ncauj,
tsaug zog
nyuaj siab maum
cwj pwm txawv
txob taus
tsis meej kev tsiv
ntshai
kev hais lus thiab pom qhov muag tsis zoo,
insomnia
mob taub hau.

Yog tias koj tsis tuaj yeem txhaj tshuaj, txhaj tshuaj qis, tawm tsam keeb kwm ntawm kev kis mob lossis kub taub hau, thiab yog tias koj tsis ua raws li kev noj zaub mov noj, koj tuaj yeem tsim kho tus mob ntshav qab zib acidosis thiab hyperglycemia:

tsis qab los
kev nqhis dej
tsaug zog
hyperemia ntawm lub ntsej muag,
tsis nco qab txog thaum lub xeev tsis nco qab,
transient tsis pom kev thaum pib ntawm txoj kev kho.

Ua ntej koj sau cov tshuaj los ntawm cov vial, nco ntsoov tias txoj kev daws teeb meem kom pom tseeb. Yog tias muaj kev txo qis lossis cov hws khov hauv qhov kev npaj, tom qab ntawd nws siv tsis tau.

Qhov kub ntawm cov tshuaj rau kev tswj hwm yuav tsum sib haum rau chav tsev kub.

Tseem ceeb! Yog tias tus neeg mob tau mob kis, mob qog, hypopituitarism, Addison tus kab mob, lub raum tsis ua haujlwm ntev, nrog rau cov neeg muaj hnub nyoog 65 xyoos, yuav tsum tau txhaj tshuaj kho cov tshuaj insulin.

Cov laj thawj ntawm kev ua ntshav siab tuaj yeem yog:

Hloov chaw ntawm cov tshuaj.
Noj ntau dhau.
Tsis noj mov.
Cov kab mob uas txo qis qhov xav tau ntawm cov tshuaj.
Ntuav, raws plab.
Kev ua haujlwm ntawm lub adrenal cortex.
Kev ntxhov siab ntawm lub cev.
Hloov thaj chaw txhaj tshuaj.
Kev cuam tshuam nrog lwm yam tshuaj.

Thaum pauv tus neeg mob los ntawm tsiaj cov tshuaj insulin rau tib neeg cov tshuaj insulin, ua rau cov ntshav qab zib tsawg zuj zus.

Kev piav qhia ntawm kev nqis tes ntawm cov tshuaj Rosinsulin P

Rosinsulin P hais txog cov tshuaj uas muaj cov nyhuv luv luv hypoglycemic. Ua ke nrog cov receptor ntawm cov roj ntsha ntawm sab nraud, cov tshuaj ua rau cov insulin receptor complex. Qhov no ua:

nce lub synthesis ntawm cyclic adenosine monophosphate nyob rau hauv daim siab thiab rog hlwb,
txhawb cov txheej txheem intracellular (pyruvate kinases, hexokinases, glycogen synthases thiab lwm tus).

Txo hauv cov ntshav qab zib cov ntsiab lus tshwm sim vim yog:

nce kev thauj intracellular,
kev tsim kho ntawm glycogenogenesis, lipogenesis,
protein ua kom sib haum
txhim kho kev nqus ntawm cov tshuaj los ntawm cov ntaub so ntswg,
txo qis hauv kev puas tsuaj ntawm glycogen (vim txo qis ntawm cov piam thaj los ntawm nplooj siab).

Tom qab tswj hwm subcutaneous, cov nyhuv ntawm cov tshuaj tshwm sim hauv 20-30 feeb.Qhov siab tshaj plaws nyob rau hauv cov ntshav tau tiav tom qab 1-3 teev, thiab txuas ntxiv ntawm kev nqis tes ua yog nyob ntawm qhov chaw thiab txoj kev ntawm kev tswj hwm, koob tshuaj thiab tus yam ntxwv ntawm tus neeg mob.

Kev ntsuas rau siv

Rosinsulin P yog siv rau hauv cov xwm txheej hauv qab no:

Ntshav qab zib mellitus yam 1 thiab 2.
Ib nrab tawm tsam cov tshuaj hauv lub qhov ncauj hypoglycemic.
Kev sib txuas ua ke
Ketoacidotic thiab hyperosmolar coma.
Ntshav qab zib ketoacidosis.
Mob ntshav qab zib muaj tshwm sim thaum cev xeeb tub.

Rau kev siv sib quas ntus:

thaum yug menyuam, kev raug mob, kev phais mob,
ua ntej yuav hloov mus txhaj tshuaj nrog rau kev npaj tshuaj insulin ntev,
nrog cov teeb meem metabolic,
nrog mob sib kis nrog kub taub hau.

Cov tshuaj tiv thaiv thiab muab ntau npaum li cas

Cov tshuaj tiv thaiv yog hypoglycemia, kev tiv thaiv tsis txaus.

Cov kab ke ntawm kev tswj hwm ntawm kev siv tshuaj thiab cov koob tshuaj hauv txhua kis tau yog txiav txim siab ib tus zuj zus. Lub hauv paus rau kev txiav txim siab cov koob tshuaj yog cov piam thaj hauv cov ntshav ua ntej thiab tom qab noj mov, chav kawm ntawm tus kab mob thiab cov ntshav qabzib.

Rosinsulin P yog npaj rau subcutaneous, pob leeg thiab intramuscular thawj coj. Kev txhaj tshuaj tas ua tiav 15-30 feeb ua ntej noj mov. Feem ntau cov feem ntau, qhov kev daws teeb meem tau muab tshuaj subcutaneously.

hauv kev ua haujlwm phais mob, mob ntshav qab zib ketoacidosis thiab coma, rosinsulin P yog muab tshuaj rau txoj leeg thiab intramuscularly, rau qhov no nws yog qhov yuav tsum paub txog kev txhaj tshuaj insulin kom raug thiab raug.

Nrog kev kho mob monotherapy, cov naj npawb ntawm cov kev txhaj tshuaj ib hnub yog 3 zaug. Yog tias tsim nyog, tuaj yeem nce ntxiv txog 5-6 zaug. Txhawm rau kom tsis txhob txhim kho cov lipodystrophy, cov roj ntsha ua rau lub cev hypertrophy, atrophy, nws yog qhov yuav tsum tau hloov chaw txhaj tshuaj txhua lub sijhawm.

angioedema,
txog siav
txo hauv cov ntshav siab,
urticaria
npaws.

tawm hws zoo,
tachycardia
kev zoo siab
tsaug zog
pallor ntawm daim tawv nqaij,
kev tshaib kev nqhis
kev xav ntawm kev ntxhov siab
hws
tshee hnyo
paresthesia nyob rau hauv lub qhov ncauj,
kev hais lus thiab pom qhov muag tsis zoo,
tsis meej kev tsiv
kev nyuaj siab
cwj pwm coj txawv txawv
txob taus
apathy
insomnia
mob taub hau.

Tawm tsam keeb kwm yav dhau los ntawm kev kis tus kab mob los yog kub taub hau, nrog rau kev txhaj tshuaj tsis nco qab, ib koob tshuaj qis, thiab yog tias kev noj zaub mov tsis ua raws, tus neeg mob yuav muaj kab mob ntshav qab zib acidosis thiab hyperglycemia:

tsis qab los noj mov
kev nqhis dej
tsaug zog
o ntawm lub ntsej muag
tsis nco qab txog thaum lub xeev tsis nco qab,
transient tsis pom kev thaum pib ntawm txoj kev kho.

Ua ntej koj sau cov rosinsulin C los ntawm ib lub khob, koj yuav tsum ua kom qhov kev daws teeb meem yog pob tshab. Yog tias poob qis lossis ua kom muaj zog nyob rau hauv insulin, nws yuav siv tsis tau. Qhov ntsuas kub ntawm kev txhaj tshuaj yuav tsum nyob ntawm chav sov.

Ua tib zoo mloog! Yog tias tus neeg mob tau kis mob, kev cuam tshuam ntawm cov thymus caj pas, hypopituitarism, Addison tus kab mob, mob raum tsis ua haujlwm, ntxiv rau cov neeg muaj hnub nyoog 65 xyoos, yuav tsum tau txhaj tshuaj insulin.

Qhov tshwm sim ntawm kev qog ntshav qab zib tuaj yeem yog:

Hloov yeeb tshuaj.
Kev noj tshuaj ntau dhau.
Tsis noj mov.
Cov kab mob uas txo qis qhov xav tau ntawm cov tshuaj.
Xeev siab, raws plab.
Ua tsis tau adrenal cortex muaj nuj nqi.
Lub cev qoj ib ce.
Hloov chaw txhaj tshuaj.
Kev cuam tshuam nrog lwm yam tshuaj.

Thaum pauv tus neeg mob los ntawm tsiaj cov tshuaj insulin rau tib neeg cov tshuaj insulin, kev txo qis hauv cov ntshav qab zib yog tau.

Cov qauv ntawm NovoMix

Tsis muaj lwm yam tshuaj nrog cov qub muaj xws li NovoMix 30 (aspart + aspart protamine), uas yog, suav ua ib qho ua tiav. Lwm yam biphasic insulins, analog thiab tib neeg, tuaj yeem hloov nws:

Neej Neeg Sib Xws 25

Neej Neeg Qhia 50

Sib xyaw	Npe	Lub teb chaws ntau lawm	Chaw tsim tshuaj paus
lispro + lispro tshuaj ntsuab	Switzerland	Eli Lilly
aspart + degludec	Ryzodeg	Denmark	NovoNordisk
tib neeg + NPH insulin	Humulin M3	Switzerland	Eli Lilly
	Gensulin M30	Lavxias	Biotech
	Insuman Comb 25	Lub teb chaws Yelemees	Sanofi aventis

Nco ntsoov tias xaiv cov tshuaj thiab nws cov tshuaj yog qhov zoo tshaj plaws nrog kws tshwj xeeb.

Nco ntsoov kawm! Koj puas xav tias kev tswj hwm kev noj qab haus huv ntawm cov tshuaj thiab cov kua dej yog ib txoj kev los tswj cov piam thaj kom tswj? Tsis muaj tseeb! Koj tuaj yeem soj ntsuam qhov no koj tus kheej los ntawm kev pib siv ... nyeem ntxiv >>

Kev taw qhia thiab contraindications

Biphasic insulin Aspart (ib qho lus sib piv ntawm Flexpen) tau siv rau hauv kev kho mob ntawm hom 1 thiab hom 2 mob ntshav qab zib mellitus yog tias nws tau dhau mus ua theem insulin-tiv thaiv theem.

Cov tshuaj tsis siv nrog ib tus neeg tsis kam mus rau nws cov khoom siv thiab nrog kev nkag siab ntau ntxiv rau lawv. Daim ntawv thov rau cov menyuam yaus hnub nyoog qis dua 6 xyoo tsis tau raug tshawb fawb, yog li ntawd nws tsis pom zoo siv qee tus neeg sawv cev ntawm lawv lub hnub nyoog no.

Cev xeeb tub siv cov ntaub ntawv no xwb. Kev kuaj mob puv ntoob tsis tau tshawb nrhiav. Tib yam siv rau FlexPen thiab Novorapid Penfill. Tab sis hauv ob txoj kev tshawb nrhiav ntawm cov tshuaj Novorapid Penfill rau cov poj niam cev xeeb tub, tsis muaj cov ntaub ntawv tau txais los ntawm qhov tsis zoo ntawm lub cev rau lub cev xeeb tub thiab qhov mob ntawm tus menyuam.

Cov leej niam uas tseem muaj cuab kav siv tau cov tshuaj insulin hauv cov nyiaj uas nws xav tau, nws tsis cuam tshuam rau tus menyuam. Nws kuj yuav tsim nyog kho qhov koob tshuaj rau tus niam.

Kev phiv tshuaj tsis zoo tshwm sim nyob rau hauv daim ntawv ntawm qhov tseem ceeb ua ntawm no. Lub xeev ntawm hypoglycemia thaum siv cov tshuaj biphasic tshwm sim ntau tsawg dua li niaj zaus noj ntau dua.

Qee zaum cov kev mob tshwm sim hauv qab no tshwm sim:

Urticaria, tawv nqaij ua pob, tsis tshua muaj - anaphylactic kev tsis haum.
Mob paj hlwb peripheral.
Refractory ntshawv siab (tsis tshua muaj thaum pib kho), retinopathy.
Lipodystrophy ntawm thaj chaw txhaj tshuaj.
Cov tshuaj tiv thaiv hauv zos ntawm cov ntsiab lus ntawm thawj coj.

Noj qee yam tshuaj yog nrog los ntawm kev nce ntxiv hauv cov txiaj ntsig Aspart thiab qhov ua tau ntawm kev muaj qog ntshav qab zib:

Qhov ncauj txwv tsis pub muaj.
Inhibitors ntawm MAO, ACE.
Cov tshuaj tiv thaiv kab mob.
Thiazide diuretics.
Heparin.

Cawv yuav ua tau ob qho kev txhim kho thiab ua rau cov nyhuv ntawm kev kho hormonal.

Kev cais tawm cov Insulin

Bovine, nqaij npuas, thiab cov kua dej ntawm tib neeg yog cov zais, nyob ntawm lawv cov keeb kwm. Thawj 2 hom tsis tshua nyiam siv nyob rau niaj hnub no. Qhov thib peb, tshwj xeeb tshaj yog tau siv siv kev tsim kho tshuab engineering, yog thawj qhov kev xaiv rau kev kho tshuaj insulin.

Raws li lub sijhawm ua ntawm kev txiav txim, muaj:

IUD - ultra luv-ua yeeb yam insulins,
ICD - Cov yeeb yam luv luv,
ISD - tshuaj ntawm nruab nrab lub sijhawm ntawm kev txiav txim,
IDD - ua yeeb yam ntev,
cov tshuaj insulins (muaj cov tshuaj insulin ntawm cov sijhawm ua haujlwm txawv).

Lub hauv paus ntsiab lus ntawm kev ua ntawm insulin thiab nws cov cuam tshuam

Cov tshuaj insulin yog polypeptide hormone. Nquag, nyob rau hauv β-hlwb ntawm tus txiav txim siab ua ntej nws txoj kev tsim tawm - proinsulin, los ntawm C-peptide yog tom qab ntawd tau muab pov tseg thiab cov tshuaj insulin yog tsim. Nrog rau kev nce ntxiv hauv cov ntshav qabzib, nrog kev voos ntawm lub paum ntawm lub paum, nrog rau hauv qab ntawm tus lej ntawm lwm yam, cov txheej txheem ntawm insulin tso tawm tau ua haujlwm.

Los ntawm qhov khi rau lub receptor ntawm daim nyias nyias ntawm lub hom phiaj cell, qhov tshuaj hormones pib ua, exerting nws cov teebmeem physiological:

ib qho kev txo qis hauv cov ntshav qab zib (nws txhawb kev nqus ntawm cov piam thaj los ntawm cov ntaub so ntswg, inhibits cov txheej txheem ntawm nws tsim nyob rau hauv lub cev los ntawm lwm yam),
activates glycogen synthesis,
inhibits qhov tsim ntawm ketone lub cev,
inhibits qhov tsim los ntawm cov piam thaj los ntawm cov tsis-carbohydrate lub tebchaw,
ua kom muaj kev tsim ntawm cov lipoproteins uas tsis tshua muaj siab thiab triglycerides,
qhib lub synthesis ntawm ntau yam protein,
txhawb kev tsim khoom ntawm glycogen, uas yog lub luag haujlwm ntawm lub zog ntawm lub cev,
inhibits qhov tawg ntawm cov rog, ua kom muaj kev tsim ntawm fatty acids los ntawm carbohydrates.

Cov tshuaj insulin sab nraud ua li cas hauv lub cev

Qhov tseem ceeb ntawm kev siv tshuaj insulin yog subcutaneous, tab sis thaum muaj xwm txheej ceev, kom ua tiav cov txiaj ntsig sai dua, cov tshuaj tuaj yeem raug txhaj rau hauv cov leeg lossis leeg ntshav.

Tus nqi ntawm kev nqus ntawm cov tshuaj hormones los ntawm thaj chaw tswj hwm subcutaneous nyob ntawm qhov chaw txhaj tshuaj, hom thiab koob tshuaj, qhov zoo ntawm cov ntshav ntws thiab cov leeg ua haujlwm hauv thaj chaw txhaj tshuaj, nrog rau kev ua raws li cov txheej txheem kev txhaj tshuaj.

Ultra-luv-ua yeeb yam insulins yog nqus tau sai tshaj plaws thiab twb dhau 10-20 feeb tom qab txhaj tshuaj ua rau txo qis ntshav qabzib. Lawv tau zoo tshaj tom qab 30-180 feeb (nyob ntawm qhov siv tshuaj). Siv tau rau 3-5 teev.
Cov nyhuv ntawm cov yeeb yam luv luv tshwm sim 30-45 feeb tom qab lawv tswj hwm. Lub siab tshaj plaws ntawm kev ua yog los ntawm 1 mus rau 4 teev, nws lub sijhawm yog 5-8 teev.
Cov tshuaj insulin ib nrab yog maj mam nqus los ntawm qhov chaw txhaj tshuaj thiab muab cov ntshav qab zib tsawg dua li 1-2 teev tom qab txhaj tshuaj subcutaneous. Qhov siab tshaj plaws tau sau tseg tsis pub dhau 4-12 teev, tag nrho lub sijhawm ntawm cov tshuaj yog 0.5-1 hnub.
Cov tshuaj insulin ntev ntev pib ua yeeb yam 1-6 teev tom qab kev tswj hwm subcutaneous, txo cov suab thaj kom ntau - qhov ua tiav ntawm qhov feem ntau ntawm cov tshuaj no tsis tau hais tawm, nws kav ntev txog 24 teev, uas ua rau nws yuav tsum tau txhaj tshuaj xws li 1 zaug hauv ib hnub.

Qhov "kev coj cwj pwm" ntawm cov kua dej hauv lub cev tom qab kev tswj hwm kuj tseem cuam tshuam los ntawm:

qhov tshuaj ntawm cov tshuaj (ntau dua nws yog, qhov tshuaj qeeb qeeb dua yog nqus thiab ntev dua nws ua),
thaj tsam ntawm lub cev mus rau qhov kev txhaj tshuaj tau ua (hauv plab, kev nqus yog qhov siab tshaj plaws, hauv lub xub pwg tsawg dua, hauv cov ntaub so ntswg ntawm tus ncej txawm tsawg dua),
txoj kev coj noj coj ua (nrog kev txhaj tshuaj subcutaneous, cov tshuaj yog nqus qeeb qeeb dua thaum txhaj rau cov leeg, tab sis ua haujlwm ntev dua),
ntaub so ntswg kub hauv thaj chaw tswj hwm (yog tias nws tau nce, qhov nqi nqus nce ntxiv),
lipomas lossis lipodystrophy ntawm cov ntaub so ntswg (hais txog nws yog dab tsi, nyeem hauv qab),
zaws lossis leeg ua haujlwm (txheej txheem kev nqus tau nrawm).

Hauv qee lub tebchaws, cov kws tshaj lij tabtom tshawb xyuas cov tshuaj insulin nrog cov kev coj noj coj ua yooj yim dua rau tus neeg mob. Yog li, hauv Asmeskas muaj insulin rau kev tswj hwm los ntawm kev nqus tau. Nws pib ua tom qab 30 feeb (uas cuam tshuam nrog IUD), lub siab tshaj plaws ntawm kev ua yog sau tseg tom qab txog 2 teev, nws lub sijhawm ntev txog 8 teev (uas zoo ib yam li ICD).

Kev Sib Koom NovoMix 30 FlexPen

Kev ncua rau s / c tswj hwm ntawm cov xim dawb, homogeneous (tsis muaj lumps, flakes yuav tshwm sim hauv tus qauv), thaum sawv ntsug, delaminates, tsim cov dej nag dawb thiab xim tsis muaj xim lossis yuav luag tsis muaj xim supernatant, homogeneous kev ncua yuav tsum tsim nrog ceev faj.

1 ml
tshuaj insulin aspart biphasic	100 DAIM DUAB *
tshuaj insulin aspart soluble	30%
tshuaj insulin aspart tiv thaiv lub ntsej muag crystalline	70%

Cov kev zam: glycerol, phenol, metacresol, zinc chloride, sodium chloride, sodium hydrogen phosphate dihydrate, protamine sulfate, sodium hydroxide, hydrochloric acid, dej d / thiab.

* 1 koog raug rau 35 mcg ntawm anhydrous insulin aspart.

3 ml - iav daim cartridges (1) - tshuaj ntsuab ntau lub taub tes uas siv cov tshuaj lim kom siv tas mus li (5) - pob ntawv los qhia.

Nruab nrab-lub sijhawm ua haujlwm rau tib neeg cov tshuaj insulin nrog kev maj mam pib ntawm kev ua

Ib qho piv txwv ntawm tib neeg cov tshuaj insulin ntawm ncua sij hawm nruab nrab nrog kev pib sai ntawm kev ua.

NovoMix ® 30 FlexPen ® yog ob-theem raug ncua kev kawm muaj cov kua dej tsis sib xyaw aspart (30% luv-ua yeeb yam insulin analog) thiab muaju ntawm aspart tiv thaiv insulin (70% nruab nrab-ua yeeb yam insulin analog).

Insulin aspart tau los ntawm kev xav tau DNA biotechnology siv hom kab mob ntawm Saccharomyces cerevisiae.

Nws cuam tshuam nrog ib qho kev tshwj xeeb ntawm sab cytoplasmic membrane ntawm cov hlwb thiab tsim cov txheej txheem insulin-receptor complex uas txhawb cov txheej txheem intracellular, suav nrog synthesis ntawm cov naj npawb ntawm cov enzymes tseem ceeb (hexokinase, pyruvate kinase, glycogen synthetase). Cov nyhuv hauv lub qog nqaij hlav yog cuam tshuam nrog kev nce ntawm kev thauj mus los ntau dua thiab kev nqus ntawm cov ntshav qabzib ntau dua los ntawm cov ntaub so ntswg, txhawb kev lipogenesis, glycogenogenesis, thiab txo tus nqi ntawm cov piam thaj ntau ntau los ntawm lub siab.

Piv rau cov tshuaj ua kom tib neeg cov kua dej, insulin aspart (ua kom sai ntawm tib neeg cov tshuaj insulin) pib ua sai dua, yog li nws tuaj yeem siv tam sim ua ntej noj mov (los ntawm 0 txog 10 feeb ua ntej noj mov). Cov theem siv lead ua (70%) muaj cov tshuaj insulin aspart protamine (ib qho khoom sib piv ntawm tib neeg cov kua dej ntawm lub sijhawm nruab nrab), cov nyhuv ntawm uas yog qhov zoo sib xws ntawm kev ua haujlwm ntawm tib neeg isophane insulin.

Tom qab s / c tswj hwm ntawm cov tshuaj NovoMix ® 30 FlexPen ®, cov nyhuv loj tuaj tom qab 10-20 feeb. Qhov siab tshaj plaws tau pom yog 1-4 teev tom qab txhaj tshuaj. Lub sijhawm tiv thaiv ntawm cov tshuaj nce mus txog 24 teev.

Thaum siv rau hauv cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib mellitus, NovoMix ® 30 FlexPen ® muaj cov txiaj ntsig zoo ib yam li ntawm glycated hemoglobin yog biphasic tib neeg insulin 30. Insulin aspart thiab tib neeg insulin muaj yam haujlwm hauv molar sib npaug.

Ib txoj kev tshawb nrhiav peb lub hlis uas koom nrog cov neeg mob ntshav qab zib hom 1 thiab ntshav qab zib hom 2 qhia tias NovoMix® 30 FlexPen® muaj tib txoj haujlwm ntawm glycated hemoglobin yog tib neeg biphasic insulin 30. Insulin aspart muaj tib yam kev ua rau tib neeg insulin hauv hniav puas sib npaug.

Hauv qhov kev tshawb fawb soj ntsuam koom nrog cov neeg mob hom 2 mob ntshav qab zib mellitus (n = 341), cov neeg mob tau txais kev kho mob rau cov pawg kho mob nkaus xwb nrog NovoMix ® 30 FlexPen ®, NovoMix ® 30 FlexPen ® nrog metformin thiab metformin ua ke nrog sulfonylurea derivative. Kev hloov pauv thawj qhov sib txawv ntawm HbA 1c tom qab 16 lub lim tiam ntawm kev kho mob tsis txawv hauv cov neeg mob tau txais NovoMix ® 30 FlexPen ® ua ke nrog metformin thiab hauv cov neeg mob tau txais metformin ua ke nrog sulfonylurea derivative. Hauv qhov kev tshawb nrhiav no, 57% ntawm cov neeg mob tau txhawm HbA 1c qib siab dua li 9%; hauv cov neeg mob no, NovoMix ® 30 FlexPen ® sib xyaw nrog metformin ua rau txo qis HbA 1c ntau dua li hauv cov neeg mob kho nrog metformin hauv kev sib xyaw nrog sulfonylurea derivative.

Lwm qhov kev tshawb nrhiav, cov neeg mob hom 2 mob ntshav qab zib mellitus uas tsis tuaj yeem tswj tau los ntawm kev noj tshuaj hauv qhov ncauj hypoglycemic tau randomized rau cov pawg hauv qab no: NovoMix ® 30 FlexPen ® 2 zaug / hnub (117 tus neeg mob) thiab insulin glargine 1 zaug / hnub (116 mob). Tom qab 28 lub lim piam ntawm kev tswj hwm tshuaj, qhov nruab nrab txo qis hauv HbA 1c hauv pawg NovoMix ® 30 FlexPen was yog 2.8% (qhov pib txhais tau tias yog 9.7%). 66% thiab 42% ntawm cov neeg mob siv NovoMix ® 30 FlexPen ®, thaum kawg ntawm txoj kev tshawb no, muaj HbA 1c qhov tseem ceeb hauv qab 7% thiab 6.5%, feem. Qhov txhais tau tias yoo ntshav plasma qis dua li 7 mmol / L (los ntawm 14 mmol / L thaum pib ntawm kev kawm mus rau 7.1 mmol / L).

Kev tshawb nrhiav 16 lub lis piam raug ua rau menyuam yaus thiab tub ntxhais hluas uas sib piv cov ntshav qab zib tom qab noj mov nrog NovoMix ® 30 FlexPen ® (ua ntej noj mov), tib neeg insulin / biphasic tib neeg insulin 30 (ua ntej noj mov) thiab insulin-isophan ( muab ua ntej yuav mus pw). Txoj kev tshawb no koom nrog 167 cov neeg mob hnub nyoog 10 txog 18 xyoo. Tus nqi nruab nrab ntawm HbA 1c hauv ob pawg neeg tseem nyob ze rau qhov muaj nuj nqis thawj zaug hauv txoj kev tshawb no. Tsis tas li, thaum siv NovoMix ® 30 FlexPen ® lossis biphasic tib neeg insulin 30, tsis muaj qhov sib txawv ntawm qhov tshwm sim ntawm cov ntshav qog ntshav qab zib. Kev tshawb nrhiav pom ob sab ntawm qhov muag pom tau ua rau hauv cov neeg mob ntawm cov neeg mob hnub nyoog 6 txog 12 xyoo (tag nrho ntawm 54 tus neeg mob, 12 lub lis piam rau txhua hom kev kho mob).Qhov tshwm sim ntawm cov ntshav qog ntshav qab zib thiab nce siab ntxiv tom qab noj mov hauv pab pawg siv NovoMix ® 30 FlexPen lower tau qis dua piv rau cov txiaj ntsig hauv pab pawg siv biphasic tib neeg insulin 30. HbA 1c qhov tseem ceeb ntawm qhov kawg ntawm kev kawm hauv pab pawg siv biphasic tib neeg insulin 30 tau qis dua qis dua hauv pab pawg uas tau thov NovoMix ® 30 FlexPen ®.

Hauv cov tshuaj insulin aspart, kev hloov pauv ntawm proline amino acid ntawm txoj hauj lwm B28 rau aspartic acid txo qhov nyiam ntawm molecules los ua hexamers nyob rau hauv cov kev sib xyaw NovoMix ® 30 FlexPen ® feem, uas tau pom nyob hauv tib neeg cov kua dej. Hauv qhov no, insulin aspart (30%) yog nqus tau los ntawm cov rog subcutaneous sai dua li cov tshuaj solulin hauv cov neeg insulin biphasic. Insulin aspart protamine (70%), zoo li tib neeg insulin isofan, nqus tau ntev dua.

Thaum siv NovoMix ® 30 FlexPen ® C max tshuaj insulin hauv qhov dej yog qhov nruab nrab 50% siab dua thaum siv ob-theem ntawm tib neeg insulin 30, thaum lub sijhawm nce mus txog C max yog qhov nruab nrab 2 lub sijhawm tsawg dua. Thaum cov tshuaj tau muab rau cov neeg tuaj yeem noj qab nyob zoo ntawm koob tshuaj 0.2 U / kg lub cev qhov hnyav, qhov nruab nrab C max yog 140 ± 32 pmol / L thiab tau mus txog tom qab 60 feeb.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, C max tau mus txog tom qab 95 feeb thiab tswj tau nyob rau theem siab dua 0 rau tsawg kawg 14 teev tom qab kev tswj hwm sc.

Cov tshuaj insulin concentration rov qab rau nws qib pib tom qab 15-18 teev tom qab kev txhaj tshuaj sc.

Qhov nruab nrab T 1/2, xav txog qhov nqus tus nqi ntawm cov protamin-bound feem, yog 8-9 teev.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Cov chaw muag tshuaj ntawm NovoMix ® 30 FlexPen ® hauv cov menyuam yaus thiab cov hluas tsis tau kawm. Txawm li cas los xij, pharmacokinetic thiab pharmacodynamic cov yam ntxwv ntawm soluble insulin aspart tau kawm hauv cov menyuam yaus (6 txog 12 xyoos) thiab cov hluas (13 txog 17 xyoo) uas muaj ntshav qab zib hom 1. Hauv cov neeg mob ntawm ob pawg hnub nyoog, insulin aspart tau pom los ntawm kev nqus sai thiab T qhov tseem ceeb zoo ib yam li cov neeg laus. Txawm li cas los xij, C qhov tseem ceeb hauv ob pab pawg hnub nyoog tau sib txawv, uas qhia qhov tseem ceeb ntawm cov tib neeg xaiv cov tshuaj insulin aspart koob tshuaj.

Hauv cov neeg mob laus dua, nrog rau cov neeg mob uas lub siab tsis ua haujlwm lossis lub raum tsis zoo, cov chaw muag tshuaj ntawm NovoMix ® 30 FlexPen tsis tau kawm.

Cov Ntaub Ntawv Muaj Kev Nyab Xeeb Ua Ntej

Hauv kev kuaj hauv vitro, uas suav txog kev khi rau insulin thiab IGF-1 receptors thiab cuam tshuam rau kev loj hlob ntawm tes, nws tau pom tias cov khoom ntawm aspart insulin zoo ib yam li cov insulin ntawm tib neeg. Tsis tas li ntawd, nws tau pom tias insulin aspart khi rau cov tshuaj insulin zoo ib yam li tib neeg cov insulin. Hauv kev tshawb fawb txog mob mob ntev (1 hlis) thiab mob ntev ntev (12 hlis), cov ntaub ntawv tsis tau nyob ntawm thaj chaw muaj cov tshuaj muaj kuab lom nyob rau hauv aspart insulin.