Cov tshuaj Heinemox: cov lus qhia rau kev siv

Cov ntsiav tshuaj, coated nrog pinkish-liab zaj duab xis txheej, yog oval, biconvex, nrog ib tug nqis siab tshaj, ntawm so - ib qho loj los ntawm dawb mus rau lub teeb daj nrog ntsuab tint.

Tshwjxeeb: cov hmoov nplej pob kws - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, huv si talc - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl hmoov txhuv - 20 mg, anhydrous colloidal silicon dioxide - 3.5 mg, croscarmellose sodium - 6.5 mg microcrystalline cellulose - 130,7 mg.

Lub plhaub muaj pes tsawg leeg: Opadry dawb 85G58997 Makc-Colorcon (polyvinyl cawv, titanium dioxide, talc, macrogol 3000, lecithin (kua)) - 17.32 mg, liab hlau oxide - 0.68 mg.

5 pcs. - hlwv (1) - pob khoom los ntawm cardboard.
7 Pcs - hlwv (1) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (1) - pob khoom los ntawm cardboard.
5 pcs. - hlwv (2) - pob khoom los ntawm cardboard.
7 Pcs - hlwv (2) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (2) - pob khoom los ntawm cardboard.
5 pcs. - hlwv (10) - pob khoom ntawm cardboard.
7 Pcs - hlwv (10) - pob khoom ntawm cardboard.
10 Pcs. - hlwv (10) - pob khoom ntawm cardboard.
100 pcs - hnab (1) (rau tsev kho mob) - cov kaus poom yas.
500 pcs - hnab (1) (rau tsev kho mob) - cov kaus poom yas.
1000 pcs - hnab (1) (rau tsev kho mob) - cov kaus poom yas.

Pharmacological kev txiav txim

Cov tshuaj tua kab mob los ntawm pab pawg fluoroquinolones, ua cov kab mob bactericidal. Nws ua tawm tsam ntau ntawm cov kab mob gram-positive thiab gram-tsis zoo, anaerobic, cov kab mob tiv thaiv acid thiab atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. Ua tau zoo tiv thaiv cov kab mob tiv thaiv kom tsis txhob raug beta-lactams thiab macrolides. Nws nquag tawm tsam feem ntau ntawm cov kab mob me me: gram-zoo - Staphylococcus aureus (suav nrog cov kab mob uas tsis rhiab txog methicillin), Streptococcus pneumoniae (suav nrog cov tshuaj tiv thaiv penicillin thiab macrolides), Streptococcus pyogenes (pawg A), gram-negative - Haemophilus influenzae (suav nrog thiab cov kab mob uas tsis yog-beta-lactamase tsim), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (suav nrog rau ob qho tsis-beta-tsim thiab tsis-beta-lactamase ua rau cov leeg), Escherichia coli, Enterobacter cloacae, atypical Chlamydia mob ntsws. Raws li kev tshawb fawb hauv vitro, txawm hais tias cov kab mob me me uas tau teev hauv qab no raug rau moxifloxacin, txawm li cas los xij, nws txoj kev nyab xeeb thiab kev ua haujlwm zoo hauv kev kho cov mob tseem tsis tau tsim. Gram-zoo kab mob: tus kab mob Streptococcus milleri, tus kab mob Streptococcus mitior, tus kab mob Streptococcus agalactiae, tus kab mob Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (xws li hom, methicillin rhiab), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Hom kab mob Gram-tsis zoo: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Co kab mob: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Cov kab mob Atypical: Kab mob Legionella pneumophila, Caxiella burnettii.

Blocks cov tshuaj topoisomerases II thiab IV, cov enzymes uas tswj hwm thaj chaw zoo tshaj plaws ntawm DNA, thiab muaj feem cuam tshuam hauv DNA replication, kho, thiab hloov ntaub ntawv. Cov nyhuv ntawm moxifloxacin nyob ntawm nws cov kev xav hauv cov ntshav thiab cov ntaub so ntswg. Tsawg kawg ntawm cov kab mob bactericidal luag hauj lwm yuav luag tsis txawv ntawm qhov tsawg kawg nkaus inhibitory ntau.

Cov txheej txheem tiv thaiv kev ua haujlwm, kev ua haujlwm ntawm penicillins, cephalosporins, aminoglycosides, macrolides thiab tetracyclines, tsis cuam tshuam rau cov haujlwm antibacterial ntawm moxifloxacin. Tsis muaj tus ntoo khaub lig-tiv thaiv ntawm moxifloxacin thiab cov tshuaj no. Tsis muaj lub plasmid-mediated kev txhim kho kev txhim kho tsis tau pom. Cov xwm txheej tag nrho ntawm kev tawm tsam yog tsawg. Hauv kev tshawb fawb hauv vitro tau pom tias kev tawm tsam moxifloxacin pib maj mam tshwm sim los ntawm qhov kev sib txuas sib txuas ua ke. Nrog kev rov ua kis mob mus rau microorganisms nrog moxifloxacin nyob rau hauv subminimal inhibitory ntau, BMD qhov ntsuas tsuas yog nce me ntsis. Kev tiv thaiv sib kis tau pom ntawm cov tshuaj los ntawm pab pawg fluoroquinolone. Txawm li cas los xij, qee cov kab mob gram-positive thiab anaerobic cov kab mob uas tawm tsam lwm cov fluoroquinolones muaj kev cuam tshuam moxifloxacin.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, moxifloxacin yog nqus sai thiab yuav luag txhua yam. Tom qab ib qho tshuaj moxifloxacin ntawm koob tshuaj 400 mg C max hauv cov ntshav tau tiav hauv 0.5-4 teev thiab yog 3.1 mg / L.

Tom qab ib qho kev lis ntshav ntawm ib koob tshuaj ntawm 400 mg rau 1 h, C max tau mus txog thaum kawg ntawm Txoj kev lis ntshav thiab yog 4.1 mg / l, uas sib raug rau qhov nce ntxiv ntawm kwv yees li 26% piv nrog tus nqi ntawm qhov ntsuas no thaum noj ntawm qhov ncauj. Nrog rau ntau qhov IV infusions ntawm koob tshuaj 400 mg rau 1 teev, C max sib txawv hauv qhov ntau ntawm 4.1 mg / l txog rau 5,9 mg / l. Qhov nruab nrab C ss ntawm 4.4 mg / L tau mus txog rau thaum xaus ntawm Txoj kev lis ntshav.

Kev tsis raug cai ntawm qhov tsis raug cai yog txog 91%.

Lub chaw muab tshuaj ntawm moxifloxacin thaum noj hauv ib koob los ntawm 50 mg txog 1200 mg, zoo li ntawm koob tshuaj 600 mg / hnub rau 10 hnub, yog kab.

Lub xeev kev sib luag yog mus txog hauv 3 hnub.

Kev khi rau cov ntshav protein (feem ntau albumin) yog kwv yees li 45%.

Moxifloxacin xa tawm sai heev hauv cov plab hnyuv siab raum thiab cov ntaub so ntswg. V d kwv yees li 2 l / kg.

Cov ntsiab lus siab ntawm moxifloxacin, ntau dua cov neeg hauv plasma, raug tsim nyob rau hauv lub ntsws (nrog rau alveolar macrophages), hauv cov qog ua pa ntawm lub bronchi, hauv cov hlab ntsha, hauv cov nqaij mos, tawv nqaij thiab cov qauv subcutaneous, foci ntawm o. Hauv cov kua dej interstitial thiab hauv cov qaub ncaug, cov tshuaj tau txiav txim siab hauv daim ntawv dawb, tsis muaj protein ntau, ntawm qhov siab siab tshaj hauv ntshav. Tsis tas li ntawd, muaj ntau qhov ntau ntawm cov tshuaj nquag tau txiav txim siab hauv cov plab hnyuv plab thiab lub plab peritoneal, zoo li hauv cov ntaub so ntswg ntawm poj niam lub cev.

Biotransformed rau cov neeg tsis muaj zog sulfo teb thiab glucuronides. Moxifloxacin tsis yog biotransformed los ntawm microsomal daim siab enzymes ntawm cytochrome P450 system.

Tom qab dhau lub sijhawm thib ob ntawm biotransformation, moxifloxacin raug ntiab tawm ntawm lub cev los ntawm lub raum thiab los ntawm cov hnyuv, ob qho tib si tsis hloov pauv thiab hauv daim ntawv ntawm cov tsis muaj zog sulfo teb thiab glucuronides.

Nws yog tawm hauv cov zis, nrog rau cov quav, ob qho tib si tsis pauv thiab ua rau lub cev tsis muaj zog. Nrog ib koob tshuaj 400 mg, kwv yees li 19% yog pom tsis hloov pauv hauv cov zis, li 25% nrog quav. T 1/2 yog kwv yees li 12 teev. Qhov nruab nrab tag nrho kev pom meej tom qab muab tshuaj rau ntawm 400 mg yog los ntawm 179 ml / min rau 246 ml / min.

Cov lus qhia thiab muab ntau npaum li cas:

kev mob ntsws hauv zej zog, nrog rau kev mob ntsws hauv zej zog, cov kab mob ua rau lub cev yog cov kab mob me me nrog ntau cov tshuaj tua kab mob tua kab mob *,

mob hlwb pob txha caj dab,

kev kis tsis yooj yim thiab nyuaj ntawm cov tawv nqaij thiab cov nqaij mos (nrog rau mob ko taw uas muaj mob),

muaj mob sib kis mob plab, nrog rau cov kab mob polymicrobial, suav nrog intraperitoneal abscesses,

mob tsis yooj yim ntawm cov mob hu ua pelvic plab hnyuv siab raum (suav nrog salpingitis thiab endometritis).

Nqa hinemoks sab hauv, nqos tsis tau lub cev, tsis yog zom, haus dej ntau, nyiam dua tom qab noj mov. Tsis pub tshaj qhov pom zoo koob tshuaj.

Kab mob sib kis txhua 24 teev (1 zaug hauv ib hnub), mg Sijhawm kho mob, hnub Kev tiv thaiv kab mob rau hauv lub ntsws 4007 Ex14 Kev kis mob rau lub cev txhawm rau 4005–10 Cov mob ua paug rau cov tawv nqaij thiab lub cev tsis tuaj yeem 4007 Cov kabmob sib kis ntawm cov tawv nqaij thiab kab mob subcutaneous 4007–21

Tsis pub tshaj qhov pom zoo ntawm lub sijhawm kho mob.

Tsis muaj kev hloov pauv hauv kev noj tshuaj yog yuav tsum muaj: hauv cov neeg laus laus, cov neeg mob uas lub siab tsis ua hauj lwm (chav kawm A, B ntawm Me-Pugh nplai), cov neeg mob uas tsis muaj lub raum tsis ua haujlwm (suav nrog hauv kev mob raum tsis zoo nrog creatinine Cl ≤30 ml / min / 1.73 m2, thiab ntxiv rau cov neeg kho mob txuas ntxiv mus thiab cov neeg mus kuaj ntshav tas li (peritoneal lim ntshav ntev), cov neeg mob ntawm ntau pab pawg.

Sab sij huam

Ua xua rau Heinemox Cheebtsam: ua pob, khaus, khaus.

Los ntawm cov hlab plawv: tachycardia, peripheral edema, nce ntshav siab, palpitations, mob hauv siab.

Los ntawm cov txheej txheem hauv plab: mob plab, xeev siab, raws plab, ntuav, dyspepsia, pom quav, cem quav, nce kev ua haujlwm ntawm hepatic transaminases, saj perversion.

Ntawm ib feem ntawm cov kev kuaj sim: qhov txo qis hauv prothrombin theem, kev nce amylase kev ua ub no.

Los ntawm cov kab mob hemopoietic: leukopenia, eosinophilia, thrombocytosis, thrombocytopenia, mob ntshav liab.

Los ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb txhaws: kiv taub hau, pw tsaug zog, tshee poob siab, ntxhov siab, asthenia, mob taub hau, tshee tshee, caj dab, mob caj dab, cramps, tsis meej pem, kev nyuaj siab.

Los ntawm cov leeg musculoskeletal: mob rov qab, mob pob txha, mob myalgia.

Los ntawm cov kab ke ua haujlwm: chaw mos candidiasis, chaw mos.

Cov lus nug, lus teb, tshuaj xyuas ntawm tshuaj Heinemoks

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Nosological kev faib tawm (ICD-10)

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Ntsiav tshuaj - 1 ntsiav tshuaj:

• Cov khoom siv nquag: moxifloxacin hydrochloride 436.3 mg, uas sib haum rau cov ntsiab lus ntawm moxifloxacin 400 mg.
• Cov zam: pob kws hmoov txhuv - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, huv si talc - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl hmoov txhuv nplej siab - 20 mg, anhydrous colloidal silicon dioxide - 3.5 mg, croscarmellose sodium - 6.5 mg, microcrystalline cellulose - 130.7 mg.
• Lub plhaub muaj pes tsawg leeg: Opadry dawb 85G58997 Makc-Colorcon (polyvinyl cawv, titanium dioxide, talc, macrogol 3000, lecithin (kua)) - 17.32 mg, liab hlau oxide - 0.68 mg.

5 pcs. - hlwv (1) - pob khoom los ntawm cardboard.

Cov ntsiav tshuaj, coated nrog pinkish-liab zaj duab xis txheej, yog oval, biconvex, nrog ib tug nqis siab tshaj, ntawm so - ib qho loj los ntawm dawb mus rau lub teeb daj nrog ntsuab tint.

Cov tshuaj tua kab mob los ntawm pab pawg fluoroquinolones, ua cov kab mob bactericidal. Nws ua tawm tsam ntau ntawm cov kab mob gram-positive thiab gram-tsis zoo, anaerobic, cov kab mob tiv thaiv acid thiab atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. Ua tau zoo tiv thaiv cov kab mob tiv thaiv kom tsis txhob raug beta-lactams thiab macrolides. Nws nquag tawm tsam feem ntau ntawm cov kab mob me me: gram-zoo - Staphylococcus aureus (suav nrog cov kab mob uas tsis rhiab txog methicillin), Streptococcus pneumoniae (suav nrog cov tshuaj tiv thaiv penicillin thiab macrolides), Streptococcus pyogenes (pawg A), gram-negative - Haemophilus influenzae (suav nrog thiab cov kab mob uas tsis yog-beta-lactamase tsim), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (suav nrog rau ob qho tsis-beta-tsim thiab tsis-beta-lactamase ua rau cov leeg), Escherichia coli, Enterobacter cloacae, atypical Chlamydia mob ntsws. Raws li kev tshawb fawb hauv vitro, txawm hais tias cov kab mob me me uas tau teev hauv qab no raug rau moxifloxacin, txawm li cas los xij, nws txoj kev nyab xeeb thiab kev ua haujlwm zoo hauv kev kho cov mob tseem tsis tau txhim tsa. Gram-zoo kab mob: tus kab mob Streptococcus milleri, tus kab mob Streptococcus mitior, tus kab mob Streptococcus agalactiae, tus kab mob Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (xws li hom, methicillin rhiab), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Hom kab mob Gram-tsis zoo: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Co kab mob: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Cov kab mob Atypical: Kab mob Legionella pneumophila, Caxiella burnettii.

Blocks cov tshuaj topoisomerases II thiab IV, cov enzymes uas tswj hwm thaj chaw zoo tshaj plaws ntawm DNA, thiab muaj feem cuam tshuam hauv DNA replication, kho, thiab hloov ntaub ntawv. Cov nyhuv ntawm moxifloxacin nyob ntawm nws cov kev xav hauv cov ntshav thiab cov ntaub so ntswg. Tsawg kawg ntawm cov kab mob bactericidal luag hauj lwm yuav luag tsis txawv ntawm qhov tsawg kawg nkaus inhibitory ntau.

Cov txheej txheem tiv thaiv kev ua haujlwm, kev ua haujlwm ntawm penicillins, cephalosporins, aminoglycosides, macrolides thiab tetracyclines, tsis cuam tshuam rau cov haujlwm antibacterial ntawm moxifloxacin. Tsis muaj tus ntoo khaub lig-tiv thaiv ntawm moxifloxacin thiab cov tshuaj no. Tsis muaj lub plasmid-mediated kev txhim kho kev txhim kho tsis tau pom. Cov xwm txheej tag nrho ntawm kev tawm tsam yog tsawg. Hauv kev tshawb fawb hauv vitro tau pom tias kev tawm tsam moxifloxacin pib maj mam tshwm sim los ntawm qhov kev sib txuas sib txuas ua ke. Nrog kev rov ua kis mob mus rau microorganisms nrog moxifloxacin nyob rau hauv subminimal inhibitory ntau, BMD qhov ntsuas tsuas yog nce me ntsis. Kev tiv thaiv sib kis tau pom ntawm cov tshuaj los ntawm pab pawg fluoroquinolone. Txawm li cas los xij, qee cov kab mob gram-positive thiab anaerobic cov kab mob uas tawm tsam lwm cov fluoroquinolones muaj kev cuam tshuam moxifloxacin.

Tom qab kev tswj hwm ntawm qhov ncauj, moxifloxacin yog nqus sai thiab yuav luag txhua yam. Tom qab ib koob tshuaj moxifloxacin ntawm koob tshuaj 400 mg C _max hauv cov ntshav tau nce mus txog hauv 0.5-4 teev thiab yog 3.1 mg / l.

Tom qab ib zaug tshuaj ib zaug thaum txhaj tshuaj ntawm 400 mg rau 1 h C _max ua tiav qhov kawg ntawm Txoj kev lis ntshav thiab yog 4.1 mg / l, uas sib raug rau qhov nce ntxiv ntawm kwv yees li 26% piv nrog tus nqi ntawm qhov ntsuas no thaum noj qhov ncauj. Nrog rau ntau txoj IV infusions ntawm ib koob ntawm 400 mg ntev dua 1 h C _max sib txawv hauv qhov ntau ntawm 4.1 mg / l txog rau 5,9 mg / l. Qhov nruab nrab Css ntawm 4.4 mg / L yog mus txog thaum kawg ntawm Txoj kev lis ntshav.

Kev tsis raug cai ntawm qhov tsis raug cai yog txog 91%.

Lub chaw muab tshuaj ntawm moxifloxacin thaum noj hauv ib koob los ntawm 50 mg txog 1200 mg, zoo li ntawm koob tshuaj 600 mg / hnub rau 10 hnub, yog kab.

Lub xeev kev sib luag yog mus txog hauv 3 hnub.

Kev khi rau cov ntshav protein (feem ntau albumin) yog kwv yees li 45%.

Moxifloxacin xa tawm sai heev hauv cov plab hnyuv siab raum thiab cov ntaub so ntswg. Vd muaj kwv yees li 2 L / kg.

Cov ntsiab lus siab ntawm moxifloxacin, ntau dua cov neeg hauv plasma, raug tsim nyob rau hauv lub ntsws (nrog rau alveolar macrophages), hauv cov qog ua pa ntawm lub bronchi, hauv cov hlab ntsha, hauv cov nqaij mos, tawv nqaij thiab cov qauv subcutaneous, foci ntawm o. Hauv cov kua dej interstitial thiab hauv cov qaub ncaug, cov tshuaj tau txiav txim siab hauv daim ntawv dawb, tsis muaj protein ntau, ntawm qhov siab siab tshaj hauv ntshav. Tsis tas li ntawd, muaj ntau qhov ntau ntawm cov tshuaj nquag tau txiav txim siab hauv cov plab hnyuv plab thiab lub plab peritoneal, zoo li hauv cov ntaub so ntswg ntawm poj niam lub cev.

Biotransformed rau cov neeg tsis muaj zog sulfo txuas ntxiv thiab glucuronides. Moxifloxacin tsis yog biotransformed los ntawm microsomal daim siab enzymes ntawm cytochrome P450 system.

Tom qab dhau lub sijhawm thib ob ntawm biotransformation, moxifloxacin raug ntiab tawm ntawm lub cev los ntawm lub raum thiab dhau los ntawm cov hnyuv, ob qho tib si tsis hloov pauv thiab hauv daim ntawv ntawm cov tsis muaj zog sulfo teb thiab glucuronides.

Nws yog tawm hauv cov zis, nrog rau cov quav, ob qho tib si tsis pauv thiab ua rau lub cev tsis muaj zog. Nrog ib koob tshuaj 400 mg, kwv yees li 19% yog pom tsis hloov pauv hauv cov zis, li 25% nrog quav. T1 / 2 yog kwv yees li 12 teev. Qhov nruab nrab tag nrho kev pom meej tom qab muab tshuaj rau ntawm 400 mg yog los ntawm 179 ml / min mus rau 246 ml / min.

Cov tshuaj tua kab mob ntawm cov fluoroquinolone pab pawg.

Muab tshuaj lom ntawm Heinemox

Sab hauv, 400 mg 1 lub sijhawm / hnub. Cov chav kawm ntawm kev kho mob rau exacerbation ntawm mob ntsws txhaws ntev - 5 hnub, zej zog muaj mob ntsws - 10 hnub, mob siab rau mob, mob rau daim tawv thiab cov nqaij mos - 7 hnub.

Moxifloxacin yog ntawv kho mob nrog kev ceev faj thaum muaj mob vwm (nrog rau keeb kwm), mob vwm, mob siab, tsis ua hauj lwm ntawm lub caij nyoog QT luv.

Thaum lub sij hawm kho nrog fluoroquinolones, qhov mob thiab pob txha ntawm cov leeg yuav tsim, tshwj xeeb tshaj yog rau cov neeg laus thiab cov neeg mob uas tau txais cov tshuaj tiv thaiv corticosteroids. Ntawm thawj cov tsos mob ntawm tus mob lossis mob rau txoj leeg, cov neeg mob yuav tsum tso tseg kev kho mob thiab tso cov ceg tawv uas cuam tshuam los ntawm lub nra.

Cov Tshuaj Hauv Tshuaj

Moxifloxacin yog ntau yam tshuaj tua kab mob ntawm cov fluoroquinolone koob, 8-methoxy fluoroquinolone. Nws inhibits topoisomerase II thiab topoisomerase IV, cuam tshuam rau supercoiling thiab hla kev sib txuas ntawm DNA tawg, inhibits DNA synthesis, ua rau kev hloov morphological sib sib zog nqus hauv cytoplasm, cell phab ntsa thiab ntawm daim nyias nyias ntawm cov kab mob me.Cov kab mob tsawg kawg ntawm cov kab mob moxifloxacin feem ntau yog piv rau nws qhov tsawg kawg yog inhibitory ntau (MICs).

Cov txheej txheem ua rau muaj kev txhim kho kev tiv thaiv ntawm penicillins, cephalosporins, aminoglycosides, macrolides thiab tetracyclines tsis ua txhaum kev tua kabmob ntawm moxifloxacin. Tsis muaj ib qho kev rov qab tiv thaiv ntawm cov pab pawg ntawm cov tshuaj tua kab mob thiab moxifloxacin. Txog tam sim no, tseem muaj tsis muaj kev cuam tshuam ntawm plasmid tsis kam. Zuag qhia tag nrho cov kev txhim kho ntawm kev tiv thaiv yog qhov tsawg heev (10 -7 –10 -10). Kev tawm tsam moxifloxacin tshwm sim maj mam los ntawm kev sib txuam ntau. Cov nyhuv rov ua dua ntawm moxifloxacin ntawm cov kab mob me me hauv cov ntsiab lus hauv qab MIC yog cov los ntawm tsuas yog nce me ntsis hauv MIC. Cov xwm txheej ntawm cov ntoo khaub lig-tiv thaiv rau quinolones raug sau tseg. Txawm li cas los xij, qee cov kab mob gram-zoo thiab anaerobic cov kab mob tiv taus rau lwm cov quinolones tseem muaj lub siab moxifloxacin.

Moxifloxacin hauv vitro nquag tawm tsam ntau cov kab mob gram-negative thiab kab mob gram-zoo, anaerobes, cov kab mob tiv thaiv acid thiab cov kab mob atypical xws li Mycoplasma spp., Chlamydia spp., Legionella spp.raws li cov kab mob tiv taus beta-lactam thiab tshuaj tua kab mob macrolide.

Lub spectrum ntawm kev ua haujlwm ntawm moxifloxacin suav nrog cov kab mob hauv qab no.

Gram-zoo: Gardnerella vaginalis, Tus kab mob ntsws * (suav nrog cov leeg tiv taus penicillin thiab cov kab mob uas muaj ntau yam tshuaj tua kab mob ua tsis taus), Cov kab mob Streptococcus pyogenes (pawg A) *, pab pawg Streptococcus milleri (S. anginosus *, S. constellatus *, S. intermedius *), cov pab pawg Tus kab mob Streptococcus viridans (S. viridans, S. mutans, S. mitis, S. sanguinis, S. salivarius, S. thermophilus, S. constellatus), Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus aureus (suav nrog hom kab mob methicillin-rhiab) *, coagulase-tsis zoo staphylococci (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans), suav nrog cov kab mob methicillin-rhiab.

Nyiaj Gram-negative: Haemophilus mob npaws (suav nrog cov kab kev tsim tawm thiab tsis tsim cov beta-lactamases) *, Haemophilus parainfluenzae *, Moraxella catarrhalis (suav nrog cov kab kev tsim tawm thiab tsis tsim cov beta-lactamases) *, Bordetella pertussis, Legionella pneumophila, Acinetobacter baumannii, Proteus vulgaris.

Anaerobes: Fusobacterium spp., Porphyromonas spp., Prevotella spp., Propionibacterium spp.

Atypical: Chlamydia mob ntsws *, Chlamydia trachomatis *, Mycoplasma pneumoniae *, Mycoplasma hominis, Mycoplasma genitalium, Legionella pneumophila *, Coxiella burnetii.

Gram-zoo: Enterococcus faecalis * (tsuas yog mob rhiab rau vancomycin thiab gentamicin) Enterococcus avium *, Enterococcus faecium *.

Nyiaj Gram-negative: Escherichia coli *, Klebsiella pneumoniae *, Klebsiella oxytoca, Citrobacter freundii *, Cov kab mob Enterobacter. (E. aerogenes, E. intermedius, E. sakazakii), Enterobacter cloacae *, Pantoea agglomerans, Pseudomonas fluorescens, Burkholderia cepacia, Stenotrophomonas maltophilia, Proteus mirabilis *, Morganella morganii, Neisseria gonorrhoeae. (P. rettgeri, P. stuartii).

Anaerobes: Bacteroides spp. (B. fragilis *, B. distasonis *, B. thetaiotaomicron *, B. ovatus *, B. uniformis *, B. vulgaris *), Peptostreptococcus spp., Clostridium spp.

Gram-zoo: Dab Tsi Staphylococcus aureus (cov kab mob methicillin / ofloxacin tiv thaiv tsis haum) **, coagulase-negative staphylococci (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans)methicillin leeg hnyav.

Nyiaj Gram-negative: Pseudomonas aeruginosa.

* Qhov rhiab heev rau moxifloxacin yog paub tseeb los ntawm cov ntaub ntawv soj ntsuam.

** Kev siv Heinemox tsis raug pom zoo rau kev kho mob kis mob los ntawm tus mob khaub thuas. S. aureustiv taus cov methicillin (MRSA)Cov. Nyob rau hauv cov ntaub ntawv ntawm kev xav lossis paub tseeb hais tias kis tau tus mob los ntawm MRSA, kev kho mob nrog cov tshuaj tsim nyog yuav tsum tau kho.

Kev Qhia Tawm Heinemox

Kab mob sib kis thiab mob kis los ntawm cov kab mob me me nkag siab moxifloxacin:

kev mob ntsws hauv zej zog, nrog rau kev mob ntsws hauv zej zog, cov kab mob ua rau lub cev yog cov kab mob me me nrog ntau cov tshuaj tua kab mob tua kab mob *,

exacerbation ntawm mob ntsws ntev,

mob hlwb pob txha caj dab,

kev kis tsis yooj yim thiab nyuaj ntawm cov tawv nqaij thiab cov nqaij mos (nrog rau mob ko taw uas muaj mob),

muaj mob sib kis mob plab, nrog rau cov kab mob polymicrobial, suav nrog intraperitoneal abscesses,

mob tsis yooj yim ntawm cov mob hu ua pelvic plab hnyuv siab raum (suav nrog salpingitis thiab endometritis).

* Kab mob ntsws dej liab nrog ntau cov tshuaj tua kab mob tiv thaiv muaj xws li penicillin tiv thaiv cov leeg thiab cov kab mob tawm tsam ob lossis ntau hom tshuaj tua kab mob los ntawm cov pab pawg xws li penicillins (nrog MICs ≥ 2 μg / ml), cephalosporins thib ob tiam (cefuroxime), macrolides, tetracyclines thiab trimethoprim / sulfamethoxazole.

Cov Yuav Tsum Muaj

ua kom txo tau cov mob moxifloxacin, lwm yam quinolones lossis lwm yam tshuaj,

kev fab tshuaj rau cov txiv laum huab xeeb los yog kua taum,

leeg mob puas nrog kev kho mob yav dhau los nrog quinolones,

siv cov tshuaj uas txuas ntxiv QT ncua (suav nrog cov tshuaj antiarrhythmic hauv chav kawm IA, III) - saib "Kev cuam tshuam",

cov neeg mob uas muaj mob los ntawm lub cev los yog tau muab cov ntawv pov thawj ncua ntev ntawm QT ntu, kev tsis haum ntawm electrolyte (tshwj xeeb tshaj yog tsis paub meej txog ntshav qab zib), thaj chaw kho mob bradycardia, thaj chaw kho mob tseem ceeb lub plawv tsis ua hauj lwm nrog kev txiav tawm ntawm sab laug ventricular ejection fraction, keeb kwm ntawm cov lus sib dhos uas cuam tshuam nrog cov tsos mob soj ntsuam (kev siv moxifloxacin Q ua rau ),

cov neeg mob uas lub siab tsis zoo ua haujlwm (Me-Pugh chav C kev faib tawm) thiab kev nce transaminase kev ua haujlwm ntau dua 5 zaug ntau dua VGN,

cov me nyuam hnub nyoog qis dua 18 xyoo

Nrog saib xyuas: Cov kab mob CNS (suav nrog cov kev tsis txaus ntseeg ntawm kev koom nrog CNS) ua rau muaj kev qaug dab peg thiab txo qis ntawm qhov pib ntawm kev ua si, cov neeg mob uas muaj keeb kwm ntawm kev puas siab ntsws thiab mob hlwb, cov neeg mob uas muaj feem ua rau muaj mob, xws li mob myocardial ischemia, tshwj xeeb tshaj yog rau cov poj niam thiab cov neeg laus laus, myasthenia gravis gravis, daim siab ua haujlwm siab, txuas nrog siv nrog cov tshuaj uas txo cov poov tshuaj.

Kev sib txuam

Tsis muaj kev cuam tshuam los ntawm kev kho mob ntawm moxifloxacin nrog atenolol, ranitidine, tshuaj ntxiv calcium, theophylline, qhov ncauj tawm tsam, glibenclamide, itraconazole, digoxin, morphine, probenecid. Kev kho ntawm cov tshuaj ntau dua thaum ua ke nrog cov tshuaj no tsis tas yuav tsum tau ua.

Antacids, ntxhia thiab multivitamins. Kev siv moxifloxacin thiab antacid npaj txhij, cov zaub mov thiab multivitamins tuaj yeem cuam tshuam kev nqus ntawm moxifloxacin vim kev tsim cov chelate ntau nrog cov cation polyvalent uas muaj nyob hauv cov tshuaj no, thiab yog li txo cov tshuaj moxifloxacin hauv cov ntshav ntshav. Hauv kev hais txog qhov no, antacid, tshuaj tiv thaiv kab mob (piv txwv li didanosine) thiab lwm yam tshuaj uas muaj cov tshuaj magnesium, aluminium, ua tiav hauv cov hlau, hlau, zinc yuav tsum noj tsawg kawg 4 teev ua ntej lossis 4 teev tom qab kev tswj hwm ntawm moxifloxacin.

Cov tshuaj uas txuas ntxiv QT ntu. Txij li moxifloxacin cuam tshuam lub sijhawm ntev ntawm QT interval, kev siv moxifloxacin nrog cov tshuaj hauv qab no yog contraindicated: antiarrhythmic IA (quinidine, hydroquinidine, disopyramide, thiab lwm yam) thiab III (amiodarone, sotalol, dofetilide, ibutilclide, thiab lwm yam) cov chav kawm, tpress phenothiazines, pimozide, sertindole, haloperidol, sultopride, thiab lwm yam), antimicrobial (sparfloxacin, erythromycin, pentamidine, antimalarial tshuaj, tshwj xeeb tshaj yog halofantrine), antihistamines (astemizole, terfenadine, misolastine) thiab lwm tus (cisis kev txaus siab, vincamine, bepridil, difemanil) cov nyiaj.

Warfarin. Thaum ua ke nrog warfarin, PV thiab lwm cov ntshav coagulation tsis hloov. Txawm li cas los xij, hauv cov neeg mob tau txais cov tshuaj anticoagulants ua ke nrog cov tshuaj tua kab mob, suav nrog nrog moxifloxacin, muaj qee kis raug nce ntxiv anticoagulation kev ua ntawm cov tshuaj anticoagulant. Cov mob txaus ntshai yog qhov tshwm sim ntawm ib qho kev kis tus kab mob (thiab cov txheej txheem ua paug), lub hnub nyoog thiab cov kab mob ntawm tus neeg mob. Txawm hais tias qhov tseeb ntawm kev sib cuam tshuam ntawm moxifloxacin thiab warfarin tsis pom, nyob rau hauv cov neeg mob tau txais kev kho mob ua ke nrog cov tshuaj no, nws yog ib qho tsim nyog los soj ntsuam INR tus nqi thiab, yog tias tsim nyog, kho qhov koob tshuaj tsis tas li ntawm anticoagulants.

Digoxin. Moxifloxacin thiab digoxin tsis cuam tshuam loj rau txhua lwm yam pharmacokinetic cov kev txwv. Nrog rov qab noj cov tshuaj ntawm moxifloxacin C_max digoxin nce ntxiv kwv yees li 30%, thaum lub txiaj ntsig ntawm AUC thiab C_min digoxin tsis hloov.

Kev ua pa roj carbon. Nrog rau kev siv txaug hluav taws xob ua ke ntawm cov pa roj carbon thiab moxifloxacin sab hauv ntawm koob tshuaj ntawm 400 mg, cov kab mob ntawm lub cev moxifloxacin txo qis dua ntau dua 80% vim los ntawm inhibition ntawm nws nqus.

GCS. Nrog rau kev siv moxifloxacin thiab corticosteroids ib txhij, kev pheej hmoo ntawm kev tsim cov leeg pob txha thiab leeg txhaws.

Tsuas tshuaj thiab tswj hwm

Sab hauv nqos tsis tau lub cev, tsis yog zom, haus dej ntau, nyiam dua tom qab noj mov. Tsis pub tshaj qhov pom zoo koob tshuaj.

Tsis pub tshaj qhov pom zoo ntawm lub sijhawm kho mob.

Tsis muaj kev hloov pauv hauv kev noj tshuaj yog yuav tsum muaj: hauv cov neeg laus laus, cov neeg mob uas lub siab tsis ua haujlwm (chav kawm A, B ntawm Me-Pugh nplai), cov neeg mob uas tsis muaj lub raum tsis ua haujlwm (suav nrog hauv kev ua haujlwm tsis zoo hauv lub raum nrog creatinine Cl ≤30 ml / min / 1.73 m 2, thiab ntxiv rau cov neeg kho mob txuas ntxiv mus thiab cov neeg mus kuaj ntshav tas li (peritoneal lim ntshav ntev), cov neeg mob ntawm ntau pab pawg.

Noj ntau dhau

Kev Kho Mob: Yog tias muaj kev noj ntau dhau, ib qho yuav tsum tau ua los ntawm cov duab saib mob thiab ua cov tsos mob txhawb nrog kev saib xyuas ECG. Kev tswj hwm ntawm cov pa roj carbon activated tam sim tom qab lub qhov ncauj tswj hwm tshuaj yuav pab tiv thaiv kev tiv thaiv moxifloxacin ntau dhau los ntawm kev siv ntau dhau.

Cov lus qhia tshwj xeeb

Qee qhov xwm txheej, tom qab siv thawj zaug ntawm cov tshuaj, hypersensitivity thiab kev tsis haum tshuaj yuav tshwm sim, uas yuav tsum ceeb toom rau tus kws kho mob tam sim ntawd. Tsis tshua muaj, kev siv tshuaj tiv thaiv kab mob tuaj yeem hloov mus rau lub neej muaj kev phom sij anaphylactic, txawm tias tom qab siv thawj zaug ntawm cov tshuaj. Hauv cov xwm txheej no, kev kho mob nrog Heinemox yuav tsum tsis ua hauj lwm txuas ntxiv thiab kev ntsuas tsim nyog kho (suav nrog kev tiv thaiv tawm tsam).

Thaum siv cov tshuaj Heinemox hauv qee tus neeg mob, ncua sijhawm ntxiv QT. Ntev lub sijhawm QT cuam tshuam nrog kev pheej hmoo ntawm kev tsim ventricular arrhythmias, suav nrog polymorphic ventricular tachycardia. Muaj qhov ncaj qha cuam tshuam ntawm qhov nce ntxiv ntawm qhov kev txiav txim ntawm moxifloxacin thiab kev nce QT ntau. Yog li ntawd, qhov koob tshuaj pom zoo (400 mg / hnub) yuav tsum tsis txhob tshaj.

Cov neeg laus thiab cov poj niam muaj kev nkag siab ntau dua rau cov tshuaj uas txuas ntxiv QT ntu. Thaum siv cov tshuaj Heinemox, txoj kev pheej hmoo ntawm kev tsim ventricular arrhythmias hauv cov neeg mob uas mob predisposing rau arrhythmias yuav nce ntxiv. Hauv kev hais txog qhov no, Heinemox tshuaj tsis tuaj yeem siv rau cov xwm txheej hauv qab no: ua ntej los yog tau txais lub sijhawm ntev ntawm QT lub sijhawm, kev tsis txaus siab hypokalemia, kev kho mob tseem ceeb bradycardia, thaj chaw kho mob tseem ceeb plawv tsis ua hauj lwm nrog kev txiav tawm sab laug ventricular ejection feem, keeb kwm ntawm lub plawv dhia tsis xws luag nrog rau kev soj ntsuam, cov thawj coj ua ke. tshuaj lengthening QT luv (suav nrog cov tshuaj antiarrhythmic ntawm chav kawm IA, III) thiab lwm tus (saib "Kev Sib Hloov").

Thaum siv cov tshuaj Heinemox, cov xwm txheej ntawm kev loj hlob ntawm tus mob muaj kab mob siab tsis txaus, tuaj yeem ua rau txoj kev txhim kho daim siab ua haujlwm, tau sau tseg. Yog tias cov tsos mob ntawm daim siab ua haujlwm tshwm sim, koj yuav tsum sab laj nrog kws kho mob ua ntej txuas ntxiv kev kho nrog tshuaj.

Thaum noj cov tshuaj Heinemox, cov xwm txheej ntawm kev txhim kho qhov mob ntawm daim tawv nqaij tawv nqaij (Stevens-Johnson syndrome lossis tshuaj lom neeg mob lom hauv lub cev) tau raug tshaj tawm. Tus neeg mob yuav tsum tau qhia paub tias yog tias muaj tsos mob ntawm daim tawv nqaij los yog hnoos qeev, nws yog qhov yuav tsum tau sab laj nrog kws kho mob ua ntej txuas ntxiv siv Heinemox.

Kev siv cov tshuaj quinolone cuam tshuam nrog kev pheej hmoo ntawm kev qaug dab peg. Heinemox yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj kab mob ntawm lub hauv nruab nrab lub paj hlwb thiab nrog kev cuam tshuam ntawm lub hauv nruab nrab cov hlab ntsha uas tuaj mus rau qhov tshwm sim ntawm qaug dab peg lossis qis dua qhov pib ntawm qhov kev ua si pov tseg.

Heinemox yuav tsum siv nrog ceev faj hauv cov neeg mob mob myasthenia gravis. gravis nyob rau hauv kev sib txuas nrog qhov ua tau exacerbation ntawm tus kab mob.

Heinemox yuav tsum siv nrog ceev faj hauv cov neeg mob uas tsis muaj cov piam thaj-6-phosphate dehydrogenase vim tias kev muaj peev xwm tsim tau ntawm hemolytic tsis haum.

Kev siv cov tshuaj tua kab mob sab nrauv, suav nrog Heinemox, cuam tshuam nrog kev pheej hmoo ntawm pseudomembranous colitis. Qhov kev kuaj pom no yuav tsum yog nyob rau hauv lub siab rau cov neeg mob uas kev mob plab zawv plab heev pom thaum kho Heinemox. Hauv qhov no, cov tshuaj yuav tsum tsis ua ntxiv thiab kev kho tsim nyog tsim nyog. Tshuaj uas inhibit plab hnyuv motust muaj contraindicated hauv kev txhim kho mob plab zawv plab heev.

Txog ntawm keeb kwm ntawm kev kho mob quinolone, suav nrog moxifloxacin, kev txhim kho ntawm txoj leeg mob thiab leeg pob txha caj qaum yog ua tau, tshwj xeeb tshaj yog nyob rau cov neeg laus thiab cov neeg mob tau txais corticosteroids ua ke. Nyob rau ntawm thawj cov tsos mob ntawm kev mob los yog mob ntawm txoj leeg, koj yuav tsum tsum tsis txhob noj cov tshuaj thiab immobilize cov ceg tawv cuam tshuam.

Moxifloxacin tsis muaj qhov ua rau lub ntsej muag, txawm li cas los xij, nws pom zoo kom tsis txhob UV hluav taws xob thaum kho nrog tshuaj, nrog rau ncaj qha tshav ntuj.

Kev siv moxifloxacin rau kev kho mob los ntawm kab mob kis tau tsis pom zoo. Dab Tsi Staphylococcus aureustiv taus cov methicillin (MRSA)Cov. Nyob rau hauv cov ntaub ntawv ntawm kev xav lossis paub tseeb hais tias kis tau tus mob los ntawm MRSA, kev kho mob nrog cov tshuaj tua kab mob tsim nyog yuav tsum tau sau tseg (saib. Pharmacodynamics).

Lub peev xwm ntawm cov tshuaj Heinemox los tiv thaiv kev loj hlob ntawm mycobacteria tuaj yeem ua rau cuam tshuam hauv vitro moxifloxacin nrog kev sim rau Mycobacterium spp.,. ua rau muaj qhov tsis zoo nyob rau hauv kev tshuaj ntsuam ntawm cov qauv ntawm cov neeg mob uas kho nrog Heinemox hauv lub sijhawm no.

Hauv cov neeg mob uas tau kho nrog quinolones, suav nrog Heinemox, cov xwm txheej ntawm qhov tsis hnov ​​mob lossis sensorimotor polyneuropathy tau piav qhia, uas ua rau paresthesia, hypesthesia, dysesthesia, lossis qaug zog. Cov neeg mob uas tau kho nrog Heinemox yuav tsum tau ceeb toom txog qhov yuav tsum tau sab laj nrog tus kws kho mob ua ntej kev kho mob txuas ntxiv yog tias muaj mob neuropathy, suav nrog kev mob, kub hnyiab, mob siab, tawv muag lossis tsis muaj zog (saib "Phiv").

Cov kev xav hauv lub cev tuaj yeem tshwm sim txawm tias tom qab thawj zaug teem los ntawm fluoroquinolones, suav nrog moxifloxacin. Muaj qee zaus, kev nyuaj siab los yog kev xav tshwm sim ntawm tus kheej mus rau txoj kev xav tua tus kheej thiab tus yam ntxwv nrog rau tus kheej txoj kev phom sij, suav nrog kev tua tus kheej (saib "Phiv"). Yog tias cov kev hloov loj no tshwm sim hauv cov neeg mob, Heinemox tshuaj yuav tsum tau txiav tawm thiab tsim nyog siv los ntsuas.

Vim tias qhov dav kis thiab qhov tshwm sim ntau dua ntawm cov mob kis los ntawm fluoroquinolone-resistant Neisseria gonorrhoeae, hauv kev kho mob rau cov neeg mob uas muaj mob ua mob rau ntawm lub plab hauv plab hnyuv siab raum, moxifloxacin monotherapy yuav tsum tsis txhob nqa tawm. Tsuas yog thaum muaj cov fluoroquinolone-resistant N. gonorrhöeae tsis suav. Yog tias nws tsis tuaj yeem ua rau cais tawm ntawm fluoroquinolone-resistant N. gonorrhöeae, nws yog qhov tsim nyog los txiav txim siab ntxiv ntawm kev kho qhov tseeb nrog moxifloxacin nrog cov tshuaj tua kab mob uas tsim nyog tawm tsam N. gonorrhöeae (Xws li cephalosporin).

Cawv rau ntawm kev muaj peev xwm tsav tsheb thiab txav tshuab. Cov tshuaj fluoroquinolones, suav nrog moxifloxacin, tuaj yeem ua rau lub peev xwm ntawm cov neeg mob tsav tsheb thiab koom nrog lwm yam kev phom sij uas xav tau kev nce siab thiab ceev ntawm psychomotor cov kev cuam tshuam vim qhov cuam tshuam rau lub hauv nruab nrab cov hlab hlwb thiab qhov muag pom.

Chaw tsim tshuaj paus

Highglans Lub chaw soj nstuam Pvt. Ltd. E-11, 12 & 13, Chaw-B, UPSIDC, Surajpur, Thaj Chaw Kev Lag Luam, Greater Noida-201306, (U.P.), Is Nrias teb.

Xov tooj: +91 (120) 25-69-742, fev: +91 (120) 25-69-743.

e-mail: [email protected], www.higlance.com

Cov sawv cev ntawm cov chaw tsim khoom hauv Lavxias Lavxias: Pharma Group LLC. 125284, Moscow, st. Khiav, 13.

Tel./fax: +7 (495) 940-33-12, 940-33-14.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj tua kab mob antimicrobial muaj muag nyob rau hauv daim ntawv ntawm ntsiav tshuaj ntawm 400 mg ntawm moxifloxacin (cov tshuaj tiv thaiv nquag).

Lwm yam tshuaj hauv qhov muaj pes tsawg leeg:

• anhydrous colloidal silicon dioxide,
• croscarmellose sodium
• cellulose microcrystals,
• magnesium stearate,
• tev talcum hmoov
• sodium lauryl sulfate,
• 3000 macrogol
• soya lecithin,
• oxide liab hlau,
• Hiav Txwv Dawb 85G58977.

Kev ntsuas rau siv

Cov kev mob tshwm sim hauv qab no thiab sib kis tau tshwm sim los ntawm cov kab mob me me yog raug rau cov tshuaj:

• mob ntsws dej hauv zej zog tsim los ntawm Streptococcus anginosus thiab Streptococcus milleri,
• mob theem ntawm daim ntawv uas muaj mob ntsws,
• sinusitis (mob), npau taws los ntawm cov kab mob pathogenic,
• Kab mob sib kis hauv plab (nrog rau cov mob hauv nruab nrog cev),
• mob voos thiab nqaij mob txhab,
• pelvic inflammatory disease, suav nrog endometritis thiab salpingitis.

Heinemox yog kho rau kev kho kab mob ntawm lub plab mos plab hnyuv siab raum.
Nrog rau cov kab mob ntawm daim tawv nqaij, Heinemox yog tus kho.Thrombomagum tsis tau hais kom ua kom lub ntsws tsis zoo.
Noj tshuaj yog tshuaj rau kev mob ntsws.
Nrog rau qhov mob ntshav siab, nws yog txoj kev coj los kho Heinemox.

Yuav ua li cas noj Heinemox

Antimicrobial ntsiav tshuaj yuav tsum tau noj qhov ncauj raws li tag nrho, ntxuav nrog dej. Nws raug nquahu kom ua qhov no tom qab noj mov.

• mob ntsws (hom mob hauv zej zog): cov tshuaj yog siv nyob rau hauv ib koob ntawm 400 mg, kev kho mob kav ntev li 1 txog 2 lis piam,
• mob ntsws (nrog exacerbation): cov tshuaj txhua hnub - 400 mg, lub sijhawm saib xyuas - 5-10 hnub,
• cov kab mob ntsws sinusitis: 400 mg ntawm cov tshuaj tau tawm hauv ib hnub, lub sijhawm tiv thaiv yog 1 lub lis piam,
• daim tawv nqaij / subcutaneous kis mob: koob tshuaj - 400 mg, ntev ntawm kev kho mob - los ntawm 1 mus rau 3 lub lis piam,
• Kev mob hauv plab - hauv plab: ntau npaum - 400 mg, lub sijhawm kho - txij li 5 txog 14 hnub,
• cov mob txhab (tsis pom meej), nyob rau thaj chaw hauv plab hnyuv plab: qhov nruab nrab txhua hnub - 400 mg, sijhawm tswj hwm - 2 lub lis piam.

Antimicrobial ntsiav tshuaj yuav tsum tau noj qhov ncauj raws li tag nrho, ntxuav nrog dej.

Lub plab zom mov

• mob plab
• xeev siab
• zawv plab
• flatulence
• tsis qab los
• mob plab
• dysphagia
• colitis (daim ntawv pseudomembranous),
• mob hnyuv.

Thaum lub caij ua haujlwm ntawm cov tshuaj, mob leeg yuav tshwm sim.
Kev mob hauv plab yog phiv cov tshuaj Thrombomag.
Thaum kho nrog Heinemox, kev poob qis hauv qab los yog qhov ua tau.
Cov tshuaj yuav ua rau mob plab zom mov.Thaum noj lub caij thrombomag, xeev siab thiab ntuav tej zaum yuav tshwm sim.

Nruab nrab hauv lub paj hlwb

• kiv taub hau
• dysesthesia / paresthesia,
• deterioration nyob rau hauv saj
• tsis meej pem,
• insomnia
• kev nyuaj siab
• ntsug
• nkees
• tsaug zog
• Amnestic tshwm sim
• muaj teeb meem nrog hais lus muaj nuj nqi,
• kev hyperesthesia.

Thaum noj tshuaj, qhov ua kom pom dav dav yog tsis muaj zog.
Kev nyob tuab si taub hau yog ib phiv los ntawm kev noj tshuaj Aspirin.
Insomnia yog ib qho tshuaj phiv los ntawm cov tshuaj.
Heinemox yuav ua rau koj nkees nkees.

Los ntawm ib sab ntawm cov metabolism

• hyperuricemia
• nce bilirubin qib,
• hyperglycemia
• hyperlipidemia.

• eosinophilia
• tshuaj tiv thaiv anaphylactic,
• ua pob
• Quincke's edema
• laryngeal o (lub neej txoj sia).

Kev hnov ​​lus tsis zoo thiab qias neeg tuaj yeem tshwm sim qee zaum.

Thaum kho nrog Heinemox, ua kom pom kev cuam tshuam ntawm lub plawv tsis ua haujlwm.

Cawv tau zoo

Cov khw tsis muab ntaub ntawv hais txog qhov sib txuam no.

Avelox yog ib qho khoom sib txig ntawm Heinemox.
Cov se ntawm cov tshuaj Heinemox - Maxiflox.
Hloov chaw ntawm Heinemox, Vigamox qee lub sijhawm kho mob.Qee zaum Rotomox yog tshuaj noj hloov Heinemox.

• Avelox,
• Maxiflox
• Vigamox
• Moksimak,
• Moxigram
• Aquamax
• Alvelon MF,
• Ultramox
• Simoflox,
• Rotomox,
• Plevilox,
• Moflaxia.