Liraglutide rau kev kho cov rog: cov lus qhia ntawm cov tshuaj

Lub radar hais txog cov cuab yeej xws li Liraglutid. Nws yog siv los tswj cov piam thaj hauv cov ntshav ntawm cov ntshav qab zib. Cov tshuaj no feem ntau pom nyob rau hauv lub npe Viktoza lossis Saksenda.

Liraglutide yog cov tshuaj nquag ntawm lub hauv paus uas nws tsim. Lub luag haujlwm tseem ceeb ntawm cov khoom siv no yog txhawm rau txo cov piam thaj hauv ntshav.

Siv cov khoom kom zoo zoo, vim nws muaj cov kev mob tshwm sim thiab contraindications. Ua ntej yuav teem caij, tus kws kho mob tshuaj xyuas thiab tshuaj ntsuam daim duab ntawm tus kab mob. Hauv lub neej yav tom ntej, cov chav kawm ntawm kev kho mob yuav tsum tau saib xyuas hauv kev tiv thaiv kom tiv thaiv kev txhim kho hypoglycemia thiab lwm yam kev tsis txaus siab.

Dab tsi yog liraglutide

Hauv xyoo 2009, cov tshuaj liraglutide tshwm sim hauv tebchaws Russia, uas yog tsim tawm hauv Denmark thiab siv los kho ntshav qab zib yam tsis muaj kev cuam tshuam los ntawm insulin. Cov khoom siv yooj yim yog agonist (daim qauv) ntawm glucagon-zoo li peptide GLP-1, yuav luag tsis txawv ntawm cov roj ntsha ntawm tib neeg cov roj ntsha, thiab yog li tsis lees paub los ntawm lub cev ua tus neeg sawv cev txawv teb chaws.

Tus txheej txheem ntawm kev txiav txim rau poob phaus

Cov twj yog muaj nyob rau hauv daim ntawv ntawm ib rab koob xwj rau kev txhaj tshuaj subcutaneous. Los ntawm kev kis tus kab mob rau lub txiav, nws txhawb cov kua dej tso kua mis tawm thiab txo cov mob hyperlycemia. Nws tau pom tias nyob hauv ib nrab ntawm cov neeg mob, qhov hnyav nce txog 5-10% thaum lub hli siv. Kev rog rog thiab poob phaus tshwm sim vim kev tsuj ntawm kev tshaib kev nqhis thiab kev siv lub zog. Liraglutide rau kev kho cov rog muaj cov yam ntxwv li nram no:

• lowers ntshav qab zib
• nce cov zaub mov saturation,
• Raws li kev txheeb xyuas, suppresses qab los noj mov.

Cov tshuaj yeeb tshuaj nrog liraglutide

Qhov kev txhaj tshuaj uas muaj qhov tshuaj nyob ntawm chav kawm ntawm incretins. Tsis muaj cov ntsiav tshuaj. Qhov no yog cov tshuaj Viktoza thiab nws cov generic Saksenda (muaj cov khoom siv tib yam, tab sis yog tsim los ntawm lwm cov chaw tsim khoom). Ob qho tshuaj no yog siv los kho mob ntshav qab zib, hauv kev poob phaus hauv cov neeg laus. Lawv tau muab tshuaj rau lub cev qhov ntsuas ntau tshaj 30 lossis 27, yog tias muaj kub siab.

Lub hom phiaj tseem ceeb ntawm cov tshuaj liraglutide yog pab txhawm rau txhawm rau tsim cov tshuaj insulin, thiab lub hom phiaj ntxiv yog txhawm rau txhim kho kev sib pauv ntawm cov piam thaj mus rau lub zog, tsis yog rog. Tus cwj mem Viktoza muaj cov khoom xyaw nquag, ntxiv nrog sodium hydrogen phosphate dihydrate, phenol, sodium hydroxide, dej thiab propylene glycol. Ib qho syringe muaj 3 ml ntawm cov tshuaj, qhov nruab nrab kev ua lag luam yog $ 158 lossis 9,500 rubles.

Victoza rau qhov hnyav tuaj yeem hloov los ntawm Saxenda, kuj tseem muaj nyob hauv cov qauv ntawm cov npiv, tab sis twb 5 pcs. 3 ml ntawm kev daws txhua (tus nqi 27 txhiab rubles). Tsis tas li ntawd, cov muaj pes tsawg leeg suav nrog propylene glycol, sodium hydroxide, phenol, sodium hydrogen phosphate dihydrate (coincidence nrog cov muaj pes tsawg leeg ntawm Viktoza). Tsis zoo li Victoza, Saxenda muaj cov kev mob tshwm sim tsawg dua.

Cov Yuav Tsum Muaj

Kev txwv tsis pub siv cov tshuaj uas muaj cov tshuaj loraglutide:

• inflammatory txheej txheem nyob rau hauv cov hnyuv,
• kev nyuaj siab mob hlwb
• mob siab, kab mob pancreatitis,
• cev xeeb tub, lactation,
• ntshav qab zib hom 1
• haus dej cawv thaum kho (zoo tsis tau tsim),
• mob ketoacidosis,
• lub raum khiav tsis zoo, lub siab,
• paresis ntawm lub plab
• hypersensitivity rau lub ntsiab lus ntawm cov yeeb yam.

Tus txheeb ze sib txuas rau cov khoom siv ntawm cov khoom siv liraglutide:

• kab mob plawv thiab leeg,
• lub plawv tsis ua hauj lwm
• noj tshuaj muaj GLP-1,
• hnub nyoog txog 18 xyoo thiab tshaj 75 xyoo,
• txais tos ntawm txhais tau tias poob phaus.

Sab sij huam

Cov uas noj cov tshuaj tuaj yeem tsim kev tsis zoo:

• ntshav qab zib,
• tsis qab los
• apnea
• cem quav, raws plab, ntaus,
• mob taub hau
• lub cev qhuav dej
• kev nyuaj siab, qaug zog, nkees, txo qis kev ua haujlwm,
• kev tsis nco qab.

Cov lus qhia rau kev siv Liraglutida

Kev npaj Saksenda thiab Viktoza tsuas yog tswj xyuas subcutaneously xwb, ib hnub ib zaug tib lub sijhawm. Nws yog qhov zoo dua yog xaiv rau kev txhaj tshuaj ncej puab, lub plab lossis xub pwg. Thawj koob tshuaj yuav yog 1.8 mg, nyob rau lub sijhawm nws tuaj yeem nqa txog 3 mg. Koj tsis tuaj yeem nkag ib qho koob tshuaj rau ob zaug rau ib hnub. Lub sijhawm rau kev kho mob ntev li ntawm 4 hlis txog rau ib xyoos, nws yog qhov tsim nyog rau kev ua kis las tib lub sijhawm, ua raws kev noj haus. Ua ke nrog liraglutide, thiazolidinediones thiab metformin tuaj yeem raug kho.

Kev siv tus cwj mem uas qhwv siv

Qhov kev daws teeb meem tau muab tsuas yog subcutaneously. Cov kua yuav tsum nyob ntawm chav sov. Cov theem siv:

1. Tshem tawm lub hau ntawm tus tes, tshem daim ntawv lo ntawm rab koob, tuav nws ntawm lub hau, ntxig nws rau hauv qhov taub. Tig los ntawm xov, kaw lub koob.
2. Tshem tawm huab cua los ntawm kev tshem lub hau ntawm rab koob thiab tig kawg mus rau hauv qab. Co lub koob txhaj tshuaj kom tso pa, nias lub pob kom poob tawm los ntawm qhov taub ntawm rab koob.
3. Tig lub pob txhaj tshuaj mus rau qhov xav tau koob ntawm cov nplai los ntawm kev hloov cov koob txhaj tshuaj. Tus naj npawb hauv lub thawv yuav qhia qhov tshuaj.
4. Txhua zaus koj yuav tsum tau txhaj ib qhov chaw rau lwm qhov. Ntxuav thaj chaw txhaj tshuaj nrog cawv cawv so, qhuav, tuav cov koob txhaj tshuaj nrog ib txhais tes, thiab quav nrog rau lwm yam. Ntxig rau rab koob, tso lub khawm, nias lub pob ntawm lub taub, tso tom qab 10 vib nas this.
5. Tshem tawm rab koob ntawm daim tawv nqaij thaum tuav lub khawm. Clamp qhov chaw txhaj tshuaj nrog tus ntswg, nco ntsoov tias muaj 0 ntawm lub qhov rais.
6. Txuas lub koob, muab tso rau ntawm lub hau, tig nws, unscrew lub koob, pov tseg. Hloov lub hau.
7. Khaws cov koob txhaj tshuaj rau nws qhov khoom ntim zoo. Nws yog txwv tsis pub tawm ntawm rab koob rau ntawm lub cev thiab siv nws ob zaug.

Cov qauv ntawm Victoza thiab Saxends

Hloov tshuaj nrog cov cuab yeej nram qab no uas tuaj yeem yuav tom kwv yees tus nqi:

1. Forsyga - 2500 p., Txo qis ntshav qab zib.
2. Orsoten - 650 p., Capsules rau poob phaus, nrawm glucogone metabolism.
3. Liksumiya - 6750 p., Txo qis ntshav qab zib.
4. Ximia - 2000 p., Pib muaj kev rog.
5. Reduxin - 1400 rubles, txo qhov hnyav, pab txhawb kev rog.
6. Diagninide - yog pheej yig, 200 rubles, pab nrog cov rog.
7. Belvik - 13,000 rubles, txo qhov qab los noj mov, tsis tau muag npe hauv Russia.
8. Baeta - 8000 rubles, ib qho peptide amino acid uas ua rau lub plab zom mov qis thiab txo qhov qab los noj mov, cuam tshuam rau cov kab mob pancreatic.

Kev Sau, tso daim foos thiab txiav txim pharmacological

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov tsis muaj kob, uas yog npaj rau kev tswj hwm subcutaneous. Lub ntsiab tivthaiv yog cov tshuaj Lyraglutide.

Ntxiv nrog rau nws, cov Cheebtsam suav nrog:

• propylene glycol
• hydrochloric acid
• phenol
• sodium hydrogen phosphate,
• dej.

Nws yog qhov muaj pes tsawg leeg no uas suav tias yog qhov tsim nyog tshaj plaws rau kev ua tiav cov haujlwm ua tiav raws li cov tshuaj.

Nyob rau hauv tus ntawm feem tivthaiv, cov txheej txheem ntawm insulin ntau lawm los ntawm beta hlwb yog nrawm. Vim qhov no, cov nqaij thiab cov nqaij rog ntawm lub cev nquag noj qabzib thiab rov faib nws ntawm lub hlwb, uas yuav pab txo qis cov ntsiab lus ntawm cov piam thaj hauv cov ntshav. Raws li qhov no, peb tuaj yeem hais tias cov tshuaj no yog hypoglycemic.

Qhov ua tau ntawm cov tshuaj yog siab heev, nws yog tus cwj pwm los ntawm lub sijhawm ntev raug. Nrog rau kev qhia ntawm cov tshuaj 1 zaug hauv ib hnub, nws cov nyhuv tseem mob rau 24 teev.

Kev taw qhia thiab contraindications

Ua ntej siv liraglutide, koj yuav tsum nyeem cov lus qhia thiab paub tseeb tias cov cuab yeej no haum rau tus neeg mob tshwj xeeb. Txawm tias cov kws kho mob yuav tsum tau kuaj ua ntej kom tsis txhob muaj lwm yam mob. Nws tsis tsim nyog yuav tsum noj cov tshuaj koj tus kheej.

Cov tshuaj rau ntshav qab zib hom 2 tau siv. Nws suav hais tias yog kev pabcuam thiab yog siv nrog rau lwm cov tshuaj ntawm cov pab pawg neeg hypoglycemic. Tab sis qee zaum Lyraglutide kuj tseem siv tau tshuaj kho mob ntshav siab.

Qhov xav tau rau kev kuaj mob ua ntej ntawm tus neeg mob tshwm sim vim yog cov contraindications muaj rau cov tshuaj.

Ntawm lawv yog hu ua:

• lub cev rhiab rau ib qho ntawm cov tsis muaj pes tsawg leeg,
• daim siab pathology
• raum tsis ua hauj lwm zoo,
• muaj cov txheej txheem ua mob hauv cov hnyuv,
• thawj hom ntshav qab zib
• pancreatitis
• lub plawv tsis ua hauj lwm
• endocrine system kab mob
• cev xeeb tub lub sij hawm
• kev pub mis.

Ntxiv nrog rau nruj contraindications, tseem muaj kev txwv:

• kab mob ntawm cov hlab plawv system,
• tus neeg mob lub hnub nyoog txog 18 xyoo,
• senile hnub nyoog.

Hauv cov xwm txheej no, muaj kev pheej hmoo ntawm cov teeb meem, tab sis nyob rau hauv kev saib xyuas ntawm tus kws tshaj lij nws tuaj yeem tiv thaiv nruab nrab. Yog li no, qee zaum cov neeg mob zoo li no tseem raug kho siv Liraglutid.

Cov lus qhia rau kev siv

Cov tshuaj yog tsuas yog siv rau kev txhaj tshuaj, uas yuav tsum tau ua haujlwm subcutaneously. Nkag mus rau hauv qhov muag kom zoo nkauj los yog tso ntshav tawm qhov tshuaj txhawm rau raug txwv.

Cov chaw uas haum rau cov kev txhaj tshuaj yog sab phab ntsa hauv qab plab, ncej puab lossis xub pwg. Qhov chaw txhaj tshuaj yuav tsum tau hloov tas li txhawm rau kom tsis muaj lipodystrophy. Lwm txoj cai - kev qhia ntawm cov tshuaj tsim nyog yuav tsum tau ua tib lub sijhawm.

Cov koob tshuaj ntawm cov tshuaj tau txiav txim siab ntawm tus kheej. Feem ntau, kev kho mob pib nrog ib feem ntawm 0.6 mg. Txhaj tshuaj yog ua ib zaug ib hnub. Yog tias tsim nyog, qhov koob tshuaj tau nce ntxiv rau 1.2 thiab txawm tias 1.8 mg. Kev siv liraglutide hauv ib qho nyiaj ntau dua 1.8 mg yog qhov tsis xav tau.

Ntau zaus, ntxiv rau cov tshuaj no, Metformin-based cov khoom lag luam siv.

Txhawm rau tiv thaiv hypoglycemic tej yam kev mob, chav kawm ntawm kev kho mob yuav tsum tau saib xyuas. Nco ntsoov txheeb xyuas koj cov ntshav qab zib thiab kho koj li kev kho mob. Txhawm rau hloov pauv yam tsis muaj kev pom zoo los ntawm tus kws tshaj lij tsis txaus siab.

Cov lus qhia ua video rau kev coj ntawm cov tshuaj:

Kev cuam tshuam nrog lwm yam tshuaj

Liraglutide muaj peev xwm cuam tshuam rau qhov ua tau zoo ntawm lwm cov tshuaj. Yog li, cov neeg mob yuav tsum qhia tus kws kho mob uas koom nrog rau kev siv tshuaj kom lawv tuaj yeem sau tshuaj kho kom zoo. Ntau zaus, cov kev mob tshwm sim vim qhov tseeb tias tus neeg mob siv tshuaj tsis haum.

Ceev faj thiab muab tshuaj kho yog tsim nyog nyob rau hauv hais txog cov tshuaj:

• cov kab mob hypoglycemic
• beta blockers,
• tshuaj kho mob
• ACE inhibitors
• tshuaj anabolic
• tshuaj tiv thaiv cev xeeb tub,
• antimycotic tshuaj
• salicylates, lwm yam.

Kev tswj hwm ntawm liraglutide nrog lwm cov tshuaj feem ntau yog tso cai, tab sis feem ntau nws yuav tsum kuaj xyuas tus neeg mob cov ntshav rau nws cov ntsiab lus qab zib. Thaum tsis muaj qhov zoo ntawm qhov muaj zog, qhov ntau npau ntxiv, nrog cov tsos ntawm cov tsos mob ntawm lub qog ntshav qab zib, nws yuav tsum txo qis.

Kev npaj ntawm kev coj ua hauv cov ntsiav tshuaj

Cov laj thawj uas vim li cas cov kws tshwj xeeb yuav tsum siv cov tshuaj analogues ntawm cov tshuaj no tuaj yeem sib txawv. Rau qee tus neeg mob, txoj kev kho mob yuav tsis haum vim yog contraindications, lwm tus neeg yws txog kev phiv, rau qee yam, tus nqi yuav zoo li tsis tuaj yeem pom.

Hloov cov tshuaj nrog rau cov txhais tau tias:

1. Novonorm. Nws lub hauv paus yog Repaglinide. Lawv tso nws tawm hauv cov ntsiav tshuaj. Tus kws kho mob sau ntawv muab lub koob tshuaj, raws li cov yam ntxwv ntawm daim duab ntawm tus kabmob. Koj tsis tuaj yeem pib noj Novonorm ntawm koj tus kheej, vim tias nws muaj contraindications.
2. ReduxinCov. Cov tshuaj muaj cov nyhuv hypoglycemic. Nws cov sib xyaw ua ke ob qho tshuaj - Metformin thiab Sibutramine. Reduxine tuaj yeem siv rau hauv cov tshuaj ntsiav lossis ntsiav tshuaj.
3. DiaglinideCov. Tsim los rau kev tswj hwm qhov ncauj, tsom rau cov neeg mob ntshav qab zib. Lub ntsiab tseem ceeb hauv nws cov muaj pes tsawg leeg yog Repaglinide. Cov cuab yeej pab tswj cov qib ntshav qab zib.
4. ForsygaCov. Nws lub cev ua haujlwm nquag yog Dapagliflozin. Cov tshuaj muaj cov nyhuv hypoglycemic, tuaj yeem pab hauv kev poob phaus. Siv nws, koj yuav tsum ua raws li cov lus qhia kho mob.

Tus neeg mob lub tswv yim

Los ntawm kev tshuaj xyuas cov neeg mob uas tau coj Liraglutide, peb tuaj yeem xaus tias cov tshuaj tsis tau txais txiaj ntsig zoo los ntawm txhua tus. Qhia tias muaj cov kev mob tshwm sim muaj zog heev tom qab noj tas. Ntau tus xav txog cov txiaj ntsig ntawm qhov kev poob phaus yog qhov ua tau zoo.

Kuv tsis tau kho Liraglutide ntev. Thaum xub thawj txhua yam zoo, txawm tias qhov tsis muaj qhov tshwm sim tsis zoo ua rau kuv xav tsis thoob. Thiab tom qab ntawv tshuaj ntsuam xyuas tias kuv tau mob pancreatitis. Kuv yuav tsum tsis kam siv tshuaj.

Thaum pib ntawm kev kho mob nrog cov tshuaj no tsuas yog txaus ntshai. Kuv raug tsim txom los ntawm xeev siab, kuv lub taub hau mob tsis tu ncua, thiab vim yog lub siab ua teeb meem nws nyuaj rau kev ua haujlwm thiab txawm tias tau tawm ntawm lub txaj. Twb xav thov kom rov muab tshuaj dua. Nws nres tias cov suab thaj theem zoo li qub thiab ua haujlwm ruaj khov. Tom qab ntawd lub cev yog tej zaum siv, vim hais tias tag nrho cov tsis kaj siab tshwm sim. Kuv txuas ntxiv cov kev kho mob kom deb li deb. Kuv pom tias nws yuav pab kom poob phaus, vim tias qhov qab los noj mov yog txo qis. Rau ib nrab xyoo kuv muaj 15 kg tsawg dua, uas tso cai rau kuv ua kom zoo dua qub - lub nra ntxiv ploj mus.

Kuv siv Liraglutid tsis ntev los no, tab sis nws zoo rau kuv. Qab zib tau poob mus rau theem ib txwm, tsis muaj qhov tshwm sim tsis zoo, tab sis kuv txhawj xeeb heev. Kuv kuj xav poob phaus (Kuv hnov ​​tias nws kuj tseem siv rau qhov no), tab sis tam sim no qhov hnyav poob yog me me, tsuas yog 3 kg.

Tsis yog txhua tus neeg tuaj yeem yuav cov tshuaj no, vim nws yog ib qho kim tshaj plaws. Tus nqi kwv yees nyob hauv qhov ntau ntawm 7-10 txhiab rubles.