Galvus (Vildagliptin) > Kev khomob thiab kev tiv thaiv

Galvus yog tshuaj rau ntshav qab zib, cov tshuaj nquag ntawm vildagliptin, los ntawm cov pab pawg ntawm DPP-4 inhibitors. Cov ntsiav tshuaj ntshav qab zib Galvus tau sau npe nyob rau hauv Russia txij li xyoo 2009. Lawv tau tsim los ntawm Novartis Pharma (Switzerland).

Galvus ntsiav tshuaj rau cov ntshav qab zib los ntawm pab pawg ntawm inhibitors ntawm DPP-4 - cov tshuaj nquag Vildagliptin

Galvus sau npe rau kev kho mob ntawm cov neeg mob ntshav qab zib hom 2. Nws tuaj yeem raug siv los ua cov tshuaj nkaus xwb, thiab nws cov nyhuv yuav ua tiav cov txiaj ntsig ntawm kev noj haus thiab kev tawm dag zog. Galvus tshuaj kho ntshav qab zib kuj tseem siv tau ua ke nrog:

metformin (siofor, glucophage),
sulfonylurea derivatives (tsis tas yuav tsum ua qhov no!),
thiazolindione,
tshuaj insulin

Galvus ntsiav tshuaj ntau npaum

Tus txheej txheem koob tshuaj Galvus raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog metformin, thiazolinediones lossis tshuaj insulin - 2 zaug hauv ib hnub, 50 mg, sawv ntxov thiab yav tsaus ntuj, tsis hais noj zaub mov noj. Yog tias tus neeg mob tau sau ntawv rau 1 koob tshuaj 50 mg rau ib hnub, tom qab ntawv yuav tsum noj thaum sawv ntxov.

Vildagliptin - cov tshuaj nquag ntawm cov tshuaj rau ntshav qab zib Galvus - raug tawm los ntawm lub raum, tab sis ua rau lub cev tsis muaj zog. Yog li no, thaum pib ntawm lub raum tsis ua haujlwm, ntau npaum li cas ntawm cov tshuaj tsis tas yuav hloov pauv.

Yog tias muaj kev ua txhaum loj ntawm daim siab ua haujlwm (ALT lossis AST cov ntshav ntev li 2,5 zaug siab dua li qhov siab dua qhov ib txwm muaj), tom qab ntawd Galvus yuav tsum tau txiav txim siab nrog kev ceev faj. Yog tias tus neeg mob lub ntsej muag daj ntseg lossis lwm yam kev mob siab hauv lub siab tshwm sim, kev kho mob vildagliptin yuav tsum nres tam sim ntawd.

Rau cov ntshav qab zib hnub nyoog 65 xyoo thiab laus dua - qhov koob tshuaj Galvus tsis hloov pauv yog tias tsis muaj kab mob concomitant. Tsis muaj ntaub ntawv qhia txog kev siv tshuaj kho mob ntshav qab zib no hauv menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo. Yog li, nws tsis pom zoo kom muab nws rau cov neeg mob ntawm pawg hnub nyoog no.

Qab zib-txo cov nyhuv ntawm vildagliptin

Cov suab thaj txo cov nyhuv ntawm vildagliptin tau kawm nyob rau hauv pab pawg ntawm 354 tus neeg mob. Nws tau muab tawm tias galvus monotherapy ua ntej 24 lub lis piam ua rau txo qis cov ntshav qabzib hauv cov neeg mob uas tsis tau ua yav tas los kho lawv hom ntshav qab zib 2. Lawv glycated hemoglobin Performance index poob qis 0.4-0.8%, thiab hauv pawg placebo - los ntawm 0.1%.

Lwm qhov kev tshawb fawb piv cov kev cuam tshuam ntawm vildagliptin thiab metformin, cov tshuaj muaj ntshav qab zib nrov tshaj plaws (siofor, glucophage). Txoj kev tshawb fawb no tseem koom nrog cov neeg mob uas nyuam qhuav mob ntshav qab zib hom 2, thiab tsis tau raug kho ua ntej.

Nws muab tawm tias galvus hauv ntau qhov ntsuas kev ua tau zoo tsis qis dua rau metformin. Tom qab 52 lub lis piam (kev kho mob 1 xyoo) hauv cov neeg mob noj galvus, qib ntawm glycated hemoglobin poob qis los ntawm qhov nruab nrab ntawm 1.0%. Hauv pawg metformin, nws txo qis los ntawm 1.4%. Tom qab 2 xyoos, cov lej tseem nyob tib yam.

Tom qab 52 lub lim tiam ntawm kev noj cov ntsiav tshuaj, nws hloov tawm tias qhov kev hloov pauv ntawm lub cev hnyav hauv cov neeg mob hauv cov pab pawg ntawm vildagliptin thiab metformin yuav luag zoo li qub.

Galvus zam tau zoo los ntawm cov neeg mob dua li metformin (Siofor). Phiv los ntawm cov hnyuv huam sai sai ntau muaj tsawg. Yog li no, niaj hnub pom zoo tso cai Lavxias algorithms rau kev kho mob hom 2 ntshav qab zib tso cai rau koj pib kev kho mob nrog galvus, nrog rau metformin.

Galvus Met: vildagliptin + kev sib xyaw metformin

Galvus Met yog cov tshuaj sib xyaw ua ke uas muaj 1 ntsiav tshuaj ntawm vildagliptin ntawm koob tshuaj 50 mg thiab metformin ntawm koob tshuaj 500, 850 lossis 1000 mg. Sau npe nyob Xos Viav thaum Lub Peb Hlis 2009. Nws raug nquahu kom noj tshuaj rau cov neeg mob 1 ntsiav tshuaj 2 zaug ib hnub.

Galvus Met yog cov tshuaj sib xyaw rau hom 2 ntshav qab zib. Nws muaj vildagliptin thiab metformin. Ob qho khoom xyaw nquag hauv ib ntsiav tshuaj - yooj yim siv thiab ua tau zoo.

Kev sib xyaw ua ke ntawm vildagliptin thiab metformin yog suav tias yog qhov tsim nyog rau kev kho mob ntshav qab zib hom 2 hauv cov neeg mob uas tsis siv tshuaj metformin ib leeg. Nws qhov zoo:

cov nyhuv ntawm kev txo qis ntshav qabzib hauv lub cev tau nce ntxiv, piv nrog monotherapy nrog ib yam ntawm cov tshuaj,
qhov seem ua haujlwm ntawm cov qe hlwb hauv kev tsim tawm cov tshuaj insulin yog tshwj tseg,
lub cev hnyav hauv cov neeg mob tsis nce ntxiv,
txoj kev pheej hmoo ntawm hypoglycemia, nrog rau mob hnyav, tsis nce ntxiv,
qhov nquag ntawm cov kev mob tshwm sim ntawm metformin los ntawm kev mob plab zom mov - tseem nyob rau tib theem, tsis nce ntxiv.

Cov kev tshawb fawb tau ua pov thawj tias kev noj Galvus Met ua tau zoo dua li siv ob lub tshuaj sib xyaw nrog metformin thiab vildagliptin. Tab sis yog tias koj xav noj ib ntsiav tshuaj xwb, ces nws yooj yim dua thiab kev kho mob kom zoo dua qub. Vim tias nws tsis tshua zoo siab uas tus neeg mob yuav hnov qab lossis cuam tshuam ib yam dab tsi.

Ua qhov kev tshawb nrhiav - piv rau kev kho mob ntshav qab zib nrog Galvus Met nrog lwm cov qauv sib txawv: metformin + sulfonylureas. Sulfonylureas tau sau tseg rau cov neeg mob ntshav qab zib uas pom Metformin ib leeg tsis txaus.

Txoj kev tshawb no tau teev npe. Ntau tshaj 1300 tus neeg mob hauv ob pawg neeg tau koom nrog nws. Ntev - 1 xyoos. Nws tau muab tawm tias nyob rau hauv cov neeg mob noj vildagliptin (50 mg 2 zaug hauv ib hnub) nrog metformin, cov ntshav qabzib cov ntshav qis tsawg dua li cov neeg uas noj glimepiride (6 mg 1 zaug hauv ib hnub).

Tsis muaj qhov sib txawv hauv qhov tshwm sim rau kev txo cov ntshav qab zib. Nyob rau tib lub sijhawm, cov neeg mob hauv Galvus Met tshuaj pab pawg tau ntsib kev mob ntshav qab zib tsawg dua 10 zaug tsawg dua li cov uas tau kho nrog glimepiride nrog metformin. Tsis muaj cov neeg mob ntshav qab zib ntau hauv cov neeg mob noj Galvus Met rau lub sijhawm thawm xyoo.

Tshuaj Ntshav Qab Zib Galvus Tau Siv Ua Li Cas Nrog Insulin

Galvus yog thawj cov tshuaj mob ntshav qab zib los ntawm DPP-4 inhibitor pawg, uas tau sau npe rau kev siv tshuaj nrog cov tshuaj insulin. Raws li txoj cai, nws yog tshuaj yog tias nws tsis tuaj yeem tswj hwm tus mob ntshav qab zib hom 2 zoo nrog kev kho mob ib leeg, uas yog "insulin" ntev ntev.

Ib txoj kev tshawb nrhiav xyoo 2007 tau txheeb xyuas kev ua tau zoo thiab kev nyab xeeb ntawm kev ntxiv galvus (50 mg 2 zaug hauv ib hnub) tiv thaiv cov placebo. Cov neeg mob koom nrog qhov theem ntawm cov ntshav glycated hemoglobin (7.5-11%) tiv thaiv kev txhaj tshuaj ntawm "qhov nruab nrab" insulin nrog nruab nrab Hagedorn protramine (NPH) ntawm ntau dua 30 units / hnub.

144 cov neeg mob tau txais galvus nrog rau cov tshuaj insulin, 152 cov neeg mob ntshav qab zib hom 2 tau txais cov placebo nyob rau tom qab ntawm cov tshuaj insulin. Hauv pawg vildagliptin, qhov nruab nrab ntawm glycated hemoglobin ho nqis txog 0.5%. Hauv pawg placebo, los ntawm 0.2%. Hauv cov neeg mob uas laus dua 65 xyoo, qhov ntsuas tseem zoo dua - txo qis 0.7% ntawm keeb kwm ntawm galvus thiab 0.1% vim kev noj cov placebo.

Tom qab ntxiv galvus rau insulin, txoj kev pheej hmoo ntawm hypoglycemia poob qis, piv nrog kev kho mob ntshav qab zib, tsuas yog txhaj ntawm "nruab nrab" NPH-insulin. Hauv cov pab pawg vildagliptin, tag nrho pes tsawg ntawm cov ntshav qog ntshav yog 113, nyob rau hauv cov pawg placebo - 185. Ntxiv mus, tsis muaj ib kis los ntawm kev mob ntshav siab ntau tsawg tau sau tseg thaum kho nrog vildagliptin. Muaj 6 qhov xwm txheej zoo li no hauv pawg pab pawg.

Muaj pes tsawg leeg thiab lub zog ntawm cov ntsiav tshuaj

Sab hauv cov ntsiab lus ntawm cov ntsiav tshuaj yog raws li hauv qab no lub Cheebtsam:

cov kev tivthaiv loj yog vildagliptin,
Cov khoom siv pabcuam - cellulose, lactose, sodium carboxymethyl hmoov txhuv nplej siab, magnesium stearate.

Cov tshuaj muaj li nram no lub zog:

txhim kho cov kev ua pancreatic,
ua rau muaj kev poob qis hauv cov tshuaj insulin vim tias muaj kev txhim kho ntawm cov haujlwm ntawm lub hlwb pancreatic,
txo cov lipids teeb meem hauv cov ntshav.

Ua rau lub cev

Cov tshuaj muaj cov txiaj ntsig zoo ntawm tus neeg mob lub cev. Muaj qee zaus, muaj kev phiv loj heev. Cov tshuaj tso cai rau koj kom normalize cov ntshav qab zib vim nws cov tshuaj muaj pes tsawg leeg thiab lub zog. Nws txhim kho txoj kev ua haujlwm ntawm cov txiav thiab enzymes uas txuam nrog hauv kev zom zaws.

Cov tshuaj pab txhim kho tus neeg mob cov mob thiab cov nyhuv no tseem mob ntev. Cov nyhuv ntawm cov tshuaj yog 24 teev.

Kev tshem tawm ntawm cov tshuaj feem ntau tshwm sim nrog kev pab ntawm ob lub raum, tsawg zaus los ntawm kev zom cov hnyuv.

Yuav thov li cas?

Cov tshuaj "Galvus" yog qhia txog ntshav qab zib hom 2. Cov tshuaj tau sau tawm kom noj ob qho tshuaj noj txhua tag kis, lossis ib ntsiav tshuaj ob zaug ib hnub (sawv ntxov thiab yav tsaus ntuj). Tsis muaj qhov sib txawv ntawm kev siv cov tshuaj ua ntej noj mov lossis tom qab. Cov hom kev siv ntawm "Galvus" yuav tsum tau xaiv los ntawm nws tus kheej, suav txog lub sijhawm ntawm kev ua haujlwm thiab kev tiv taus siab ntev.

Siv cov tshuaj ntawm qhov ncauj, thaum haus ib ntsiav tshuaj nrog dej txaus. Qhov ntau thiab tsawg ntawm cov tshuaj yuav tsum tsis pub ntau tshaj 100 mg rau ib hnub.

Cov tshuaj "Galvus" yog siv raws li:

monotherapy, sib txuas nrog kev noj zaub mov noj thiab tsis muaj zog, tab sis kev ua haujlwm hauv lub cev (piv txwv li, tsuas yog "Galvus" + kev noj haus + kev ua kis las),
pib kho ntshav qab zib ua ke nrog kev noj qab zib-txo cov tshuaj Metformin, thaum kev noj zaub mov zoo thiab kev tawm dag zog ib leeg tsis muab cov txiaj ntsig zoo (piv txwv li, "Galvus" + Metformin + kev noj haus + kis las),
cov kev kho mob ua ke nrog rau cov tshuaj muaj piam thaj kom ntshav qab zib lossis insulin, yog tias kev noj zaub mov zoo, kev tawm dag zog thiab kev kho mob nrog Metformin / insulin ib leeg tsis pab (piv txwv li, "Galvus" + Metformin lossis sulfonylurea derivatives, lossis thiazolidinedione, lossis insulin + kev noj haus + kev ua si nawv),
kev kho mob sib xyaw: sulfonylurea derivatives + Metformin + "Galvus" + kev noj zaub mov noj + kev kawm lub cev, thaum muaj kev kho mob zoo sib xws, tab sis tsis muaj "Galvus" tsis ua haujlwm,
kev kho mob sib xyaw: Metformin + insulin + Galvus, thaum yav dhau los kho zoo ib yam, tab sis tsis muaj Galvus, tsis tsim cov nyhuv xav pom.

Tus mob ntshav qab zib siv cov tshuaj no feem ntau hauv ib qho tshuaj:

monotherapy - 50 mg / hnub (thaum sawv ntxov) lossis 100 mg / hnub (i.e. 50 mg thaum sawv ntxov thiab yav tsaus ntuj),
Metformin + "Galvus" - 50 mg 1 lossis 2 zaug ib hnub,
sulfonylurea derivatives + "Galvus" - 50 mg / hnub (1 lub sijhawm hauv ib hnub, thaum sawv ntxov),
thiazolidinedione / insulin (qee yam hauv cov npe) + “Galvus” - 50 mg 1 lossis 2 zaug hauv ib hnub,
sulfonylurea derivatives + Metformin + Galvus - 100 mg / hnub (piv txwv li 2 zaug hauv ib hnub, 50 mg, sawv ntxov thiab yav tsaus ntuj),
Metformin + insulin + "Galvus" - 50 mg 1 lossis 2 zaug ib hnub.

Thaum noj "Galvus" nrog kev npaj sulfonylurea, cov koob tshuaj ntawm yav tas tas txotxhawm rau txhawm rau txhawm rau txhim kho hypoglycemia!

Qhov zoo tshaj plaws, thaum noj cov tshuaj ob zaug hauv ib hnub, koj yuav tsum haus ib qho tshuaj ntxiv 12 teev tom qab daim ntawv ntxiv. Piv txwv li, thaum 8 teev sawv ntxov lawv noj 1 lub tshuaj (50 mg) thiab thaum 8 teev tsaus ntuj lawv noj 1 lub tshuaj (50 mg). Raws li qhov tshwm sim, 100 mg ntawm cov tshuaj noj ib hnub.

Qhov koob tshuaj 50 mg yog noj ib zaug, nws tsis faib ua ob zaug.

Yog tias qhov tshuaj no tsis ua rau muaj txiaj ntsig zoo, txawm hais tias txoj kev kho nyuaj dhau los, tom qab ntawd nws yuav tsum tau ntxiv lwm cov tshuaj ntxiv rau nws, tab sis nws tsis tuaj yeem ua kom ntau ntxiv ntawm qhov ntau ntawm "Galvus" tshaj 100 mg / hnub!

Cov neeg mob ntshav qab zib uas raug mob los ntawm cov mob sib khuav hauv cov plab hnyuv siab raum (xws li, ob lub raum lossis mob siab) feem ntau siv ntau npaum ntawm 50 mg. Cov neeg muaj mob xiam oob qhab loj (txawm tias lawv muaj mob raum lossis mob siab), Galvus, raws li txoj cai, tsis tau sau tseg.

Hauv cov neeg laus (txij li 60 xyoo lossis ntau dua), ntau npaum ntawm cov tshuaj no zoo ib yam rau cov hluas. Tab sis tseem, feem ntau, cov neeg laus tau hais kom noj 50 mg ib hnub ib zaug.

Txawm li cas los xij, cov yeeb tshuaj "Galvus" yuav tsum siv tsuas yog nruj me ntsis ntawm kev saib xyuas ntawm tus kws kho mob.

Hluas hom 2 mob ntshav qab zib, i.e. cov menyuam yaus thiab tub ntxhais hluas uas muaj hnub nyoog yau dua yuav tsum tsis txhob noj cov tshuaj no, vim tias nws tsis tau soj ntsuam rau pawg neeg hnub nyoog no thaum sim tshuaj.

Cov poj niam muaj menyuam hauv plab yog tsis pom zoo kom siv cov tshuaj no. Hloov chaw, nws tuaj yeem siv cov tshuaj hormonal li niaj zaus (i.e. insulin).

Txawm li cas los xij, cov kev paub ntawm tus kws kho mob tau qhia tias tsis muaj kev cuam tshuam zoo rau kev txhim kho kev xeeb tub ntawm kev noj tshuaj ntau npaum li 50 mg rau ib hnub, tab sis tseem tseem zoo dua uas yuav tsum tsis kam siv cov tshuaj no yog tias ua tau. Yog li, kev siv "Galvus" los ntawm cov niam yug yog tseem muaj, tab sis tsuas yog nrog kev sab laj ntawm cov kws tshwj xeeb.

Nws kuj tseem pom zoo kom tsis txhob noj tshuaj thaum lub sijhawm pub niam mis, vim tias tsis muaj leej twg paub tias cov tshuaj ua kom nqus mus rau hauv cov mis lossis tsis.

Ua tau contraindications

Zoo li lwm yam tshuaj, nws muaj nws cov contraindications. Yeej, txawm tias qhov tsis xav pom tshwm sim, lawv yog ib ntus thiab ploj tom qab qee lub sijhawm, yog li kev hloov ntawm cov tshuaj no mus rau lwm qhov tsis muab rau.

Cov tshuaj tiv thaiv rau cov tshuaj no yog raws li nram no:

Kev txawv txav ntawm lub cev ua haujlwm ntawm lub raum, mob siab thiab / lossis lub siab.
Metabolic acidosis, mob ketoacidosis, mob plab lactic acidosis, mob ntshav qab zib ua rau tsis nco qab lawm.
Yam 1 ntshav qab zib.
Cev xeeb tub thiab pub niam mis.
Cov me nyuam lub hnub nyoog.
Ua xua rau ib lossis ntau yam ntawm cov tshuaj.
Galactose intolerance.
Lactase tsis muaj zog.
Hnov tsis yooj yim thiab kev nqus ntawm cov piam thaj-galactose.
Tus nqi nce ntawm hepatic enzymes (ALT thiab AST) hauv cov ntshav.

Nrog kev ceev faj, cov tshuaj "Galvus" yuav tsum tau siv rau cov neeg uas yuav muaj exacerbation ntawm pancreatitis.

Sab sij huam

Cov kev mob tshwm sim feem ntau tshwm sim nrog kev noj tshuaj ntau dhau:

kiv tob hau, mob taub hau,
tshee hnyo
ua daus no
xeev siab, ntuav,
gastroesophageal reflux,
raws plab, cem quav, pom yooj yim,
ntshav qab zib,
hyperhidrosis
txo kev ua tau zoo thiab qaug zog,
peripheral edema,
hnyav.

Cov tshuaj "Galvus" yog qhia txog ntshav qab zib hom 2. Cov cuab yeej muaj nta hauv kev siv thiab ntau npaum li cas. Cov tshuaj muaj cov txiaj ntsig zoo ntawm lub cev, ua kom lub cev theem ntawm cov piam thaj hauv cov kev mob ntshav. Cov cuab yeej muaj cov kev mob tshwm sim thiab contraindications, yog li qee tus neeg yuav tsum siv nws kom zoo.

Thov

Galvus yog ib yam tshuaj uas ua rau lub xeev tsis muaj piam thaj hauv lub cev. Nws yog noj tshwj xeeb los ntawm qhov ncauj. Cov tshuaj no txhim kho cov ntaub so ntswg rhiab heev rau cov piam thaj, uas pab cov insulin sawv ntsug.

Vildagliptin yog ib yam tshuaj uas muaj nyob hauv cov tshuaj. Nws pab tswj cov kab mob pancreatic beta hlwb kom zoo.

Yog tias tus neeg tsis muaj ntshav qab zib, tom qab ntawd cov tshuaj tsis pab txhawb kev tso tawm cov kua dej thiab tsis hloov cov ntshav qabzib hauv cov ntshav ncig.

Galvus tuaj yeem ua rau cov lipids qis qis hauv cov ntshav ncig. Cov nyhuv no tsis yog tswj los ntawm kev hloov pauv hauv lub luag haujlwm ntawm cov ntaub so ntswg hlwb.

Galvus tuaj yeem txo plab hnyuv. Qhov kev ua no tsis cuam tshuam nrog kev siv vildagliptin.

Galvus Met yog lwm yam tshuaj. Ntxiv nrog rau vildagliptin, nws muaj cov tshuaj nquag metformin.

Cov cim tseem ceeb rau kev noj tshuaj rau hom 2 mob ntshav qab zib mellitus:

Rau kev kho mob monotherapy, sib txuas nrog kev noj haus thiab ua kom lub cev zoo.
Cov neeg mob uas tau siv yav tas los siv cov tshuaj uas muaj metformin hauv lawv tag nrho.
Rau kev kho mob monotherapy, sib txuas nrog metformin. Nws siv yog tias kev tawm dag zog thiab kev noj haus tsis tau coj cov txiaj ntsig xav tau.
Ib qho ntxiv rau kev kho mob insulin.
Kev ua tsis tau zoo ntawm kev sib txuas ua ke. Qee qhov xwm txheej, nws raug tso cai siv tshuaj insulin, metformin thiab vildagliptin ua ke.

Vildagliptin, yog hais tias noj rau ntawm lub plab khoob, yog nqus tau sai sai los ntawm lub cev. Thaum noj mov, tus nqi ntawm qhov nqus tsawg dua. Vildagliptin, ua rau hauv lub cev, hloov mus rau hauv cov khoom noj rau lub cev, tom qab ntawd nws tawm hauv cov zis.

Galvus tau ntsib cov lus qhia rau kev siv qhia tau hais tias tus poj niam txiv neej thiab lub cev qhov hnyav ntawm tus neeg tsis cuam tshuam rau lub chaw muag tshuaj ntawm vildagliptin.Cov kev tshawb fawb muaj peev xwm los tshawb txog qhov tshwm sim ntawm vildagliptin rau cov menyuam yaus hnub nyoog qis dua 18 xyoo tsis tau ua.

Metformin, muaj nyob hauv Galvus Met, txo qhov nqus ntawm cov tshuaj vim noj. Cov tshuaj tsis tshua cuam tshuam nrog ntshav ntshav. Metformin tuaj yeem nkag rau cov ntshav liab, cov nyhuv nce ntxiv nrog kev siv lub sijhawm ntev. Cov tshuaj yog yuav luag tag los ntawm lub raum, yam uas tsis hloov nws qhov tsos. Bile thiab metabolites tsis tau tsim.

Tsis muaj cov kev tshawb fawb twg tau ua uas qhia txog cov nyhuv ntawm Galvus rau lub cev ntawm tus poj niam cev xeeb tub. Nws tsis pom zoo kom noj cov tshuaj thaum lub sijhawm no (hloov los ntawm insulin txoj kev kho).

Cov lus qhia rau kev siv

Galvus noj tshwj xeeb los ntawm qhov ncauj. Tsis tas siv sijhawm noj mov ntxiv. Cov ntsiav tshuaj tsis yog txhaws, ntxuav cia nrog cov dej txaus.

Thaum noj tshuaj, yuav tsum tau saib xyuas tshwj xeeb rau kev siv tshuaj:

Vildagliptin nrog metformin. Thaum noj ob yam tshuaj hauv cov koob tshuaj uas tsim nyog, tsis muaj ib qho tshwm sim ntxiv pom. Vildagliptin kev siv tsis cuam tshuam nrog lwm yam tshuaj. Tsis siv nrog inhibitors. Cov nyhuv ntawm vildagliptin rau lub cev nrog rau lwm cov tshuaj uas tau sau tseg rau ntshav qab zib hom II tsis tau tsim muaj. Kev ceev faj yuav tsum xyaum.
Metformin. Yog hais tias noj nrog Nifedipine, ces tus nqi nqus ntawm metformin nce. Metformin tsis muaj kev cuam tshuam zoo rau cov khoom ntawm Nifedipine. Glibenclamide, nrog cov khoom sib xyaw, yuav tsum ua tib zoo saib: cov nyhuv yuav txawv.

Galvus yuav tsum tau ua tib zoo noj nrog cov tshuaj uas cuam tshuam rau lub raum kev ua haujlwm.

Kev siv ntawm Galvus thiab chlorpromazine tsis pom zoo. Vim tias qhov no, qib ntawm insulin secretion yuav txo qis. Yuav tsum tau txhaj kom haum.

Nws yog txwv tsis pub noj cov tshuaj uas muaj ethanol nrog Galvus. Qhov no nce lub sijhawm ntawm cov kab mob lactic acidosis. Nws tseem yog qhov yuav tsum tsis txhob haus cawv thaum haus cawv.

Cov Yuav Tsum Muaj

Galvus muaj ib tug xov tooj ntawm loj contraindications:

Lub raum khiav tsis zoo, lub raum tsis ua haujlwm.
Kab mob thiab mob uas tuaj yeem ua rau lub raum khiav tsis zoo. Ntawm cov no, lub cev qhuav dej, ua npaws, kis kab mob, thiab cov pa oxygen nyob hauv lub cev sawv ntsug.
Kab mob hauv lub plawv, myocardial infarction.
Kev ua tsis taus ntawm lub tshuab ua pa.
Daim siab ua haujlwm.
Mob lossis mob ntev ntawm cov kua qaub-lub hauv paus ua kom sib npaug. Hauv cov xwm txheej no, kev siv tshuaj insulin.
Cov tshuaj yaj yeeb tsis siv 2 hnub ua ntej kev phais mob lossis kuaj mob. Tsis tas li, tsis txhob noj ntxov dua 2 hnub tom qab cov txheej txheem.
Yam 1 ntshav qab zib.
Kev haus dej haus cawv tsis tu ncua thiab tsis tos nws. Hangover Mob.
Noj tsawg tsawg cov zaub mov. Qhov txwv qis tshaj plaws rau kev noj cov tshuaj yog 1000 calories txhua hnub.
Hypersensitivity rau ib yam tshuaj muaj nyob hauv cov tshuaj. Nws tuaj yeem hloov nrog cov tshuaj insulin, tab sis tsuas yog tom qab sab laj tus kws kho mob tshwj xeeb.

Tsis muaj ntaub ntawv qhia txog kev noj tshuaj thaum cev xeeb tub thiab lactation. Siv cov tshuaj yog contraindicated. Txoj kev pheej hmoo ntawm kev tsim muaj qhov txawv txav hauv cov me nyuam hauv plab yuav muaj ntau ntxiv. Pom zoo hloov cov tshuaj nrog kev kho tshuaj insulin.

Cov tshuaj yog contraindicated rau hauv cov menyuam yaus hauv qab lub hnub nyoog. Cov kev tshawb fawb txog hom neeg no tsis tau ua.

Cov tshuaj yuav tsum tau siv nrog ceev faj rau cov neeg laus dua 60 xyoo. Yuav tsum tau ua tib zoo saib xyuas mob nyob thoob plaws chav kawm.

Cov koob tshuaj ntawm Galvus tau sau tseg ua ib tus zuj zus rau txhua tus neeg mob. Nws nyob ntawm kev kam ntawm lub cev thiab lwm yam tshuaj siv rau kev kho mob monotherapy.

Qhov ntau npaum ntawm cov tshuaj siv rau monotherapy nrog insulin yog los ntawm 0.05 txog 0.1 g ntawm cov tshuaj nquag txhua hnub. Yog tias tus neeg mob tau mob ntshav qab zib ntau, nws raug nquahu kom pib siv tshuaj nrog 0.1 g.

Yog tias ua ke nrog Galvus ob ntau qhov nyob sib ze npaj tau siv, tom qab ntawd cov tshuaj pib nrog 0.1 g txhua hnub. Qhov tshuaj ntau ntau ntawm 0.05 g yuav tsum noj ib lub sijhawm. Yog tias qhov koob tshuaj yog 0.1 g, tom qab ntawd nws yuav tsum tau ncab dua 2 zaug: thaum sawv ntxov thiab yav tsaus ntuj.

Nrog kev kho mob monotherapy, nrog rau sulfonylurea npaj, qhov xav tau ntau npaum li cas yog 0.05 g txhua hnub. Nws tsis pom zoo kom noj ntau dua: raws li kev tshawb fawb soj ntsuam, tau pom tias qhov ntau npaum li cas ntawm 0.05 g thiab 0.1 g xyaum tsis txawv hauv qhov ua tau zoo. Yog tias cov txiaj ntsig xav tau kev kho tsis tau tiav, ces kev txiav txim ntawm 0.1 g thiab lwm yam tshuaj uas txo cov ntshav qab zib kom tso cai.

Yog tias tus neeg mob tau mob me me nrog lub raum kev ua haujlwm, ces kev hloov kho tshuaj tsis tsim nyog. Cov tshuaj yuav tsum raug txo kom tsawg li 0.05 g nyob rau hauv rooj plaub uas muaj teeb meem mob raum.

Cia peb tsiv mus rau xaiv cov tshuaj rau Galvus Met.

Cov koob tshuaj tau xaiv ib qho zuj zus rau txhua tus neeg mob. Nws tsis raug tso cai los tshaj qhov siab tshaj plaws niaj hnub kev cuam tshuam ntawm cov tshuaj nquag - 0.1 g.

Yog tias kev kho mob nrog cov Galvus zoo tib yam tsis coj cov txiaj ntsig uas xav tau, ces ntau npaum li cas yuav tsum tau pib nrog 0.05 g / 0.5 g. Cov no yog vildagliptin thiab metformin, feem. Cov koob tshuaj yuav tau nce ntxiv raws li kev ntsuam xyuas ntawm qhov ua tau ntawm kev kho mob. Yog tias metformin tsis muab cov ntsiab lus tseem ceeb hauv kev kho mob, tom qab ntawd coj Galvus Met hauv cov tshuaj hauv qab no: 0.05 g / 0.5 g, 0.05 g / 0.85 g lossis 0.05 g / 1 g. Kev txais tos yuav tsum muab faib ua 2 sij hawm.

Kev muab tshuaj thaum xub thawj rau cov neeg mob uas twb tau kho nrog metformin thiab vildagliptin yog nyob ntawm tus yam ntxwv ntawm cov kev kho. Cov no tuaj yeem yog cov koob tshuaj nram no: 0.05 g / 0.5 g, 0.05 g / 0.85 g lossis 0.05 g / 1 g. Yog hais tias kho nrog kev noj zaub mov noj thiab kev ua kom lub neej tsis muaj qhov tshwm sim, ces kev siv tshuaj yuav tsum pib nrog 0.05 g / 0.5 g, noj 1 zaug. Maj mam, qhov koob tshuaj yuav tsum tau nce ntxiv rau 0.05 g / 1 g.

Hauv cov neeg laus, feem ntau txo qis raum kev ua haujlwm yog ib txwm pom. Hauv qee qhov xwm txheej zoo li no, koj yuav tsum tau noj cov zaub mov kom tsawg kawg nkaus, uas yuav tuaj yeem tswj hwm qib suab thaj. Nws yog ib qho tsim nyog rau kev soj ntsuam tas li uas qhia txog cov xwm txheej tam sim no ntawm lub raum.

Galvus ntsiav tshuaj ntawm 0.05 g ntawm kev ua ub ua no tuaj yeem muas rau 814 rubles.
Galvus Met, tus nqi yog kwv yees li 1,500 rubles rau 30 ntsiav tshuaj nrog cov ntsiab lus sib txawv ntawm metformin thiab vildagliptin. Yog li, piv txwv, galvus meth 50 mg / 1000 mg yuav raug nqi 1506 rubles.

Ob yam tshuaj yog ntawv yuav tshuaj.

Xav txog cov tshuaj uas hloov chaw rau Galvus:

Arfezetin. Siv los ua kev kho mob ntshav qab zib. Rau kev kho tag nrho tsis haum. Yuav luag tsis muaj kev mob tshwm sim, tuaj yeem siv rau kev kho mob monotherapy. Qhov zoo yog tsis raug nqi - 69 rubles. Muag yam tsis muaj daim ntawv yuav tshuaj.
Lub Neej. Ib qho kim thiab siv tau cov tshuaj zoo. Muaj liraglutide hauv nws cov muaj pes tsawg leeg. Muaj cov qauv hauv cov koob txhaj tshuaj. Nqe - 9500 rub.
Glibenclamide. Txhawb nqa qhov tawm ntawm insulin. Muaj cov tshuaj uas muaj cov tshuaj glibenclamide hauv nws cov lus. Koj tuaj yeem yuav cov tshuaj rau 101 rubles.
Glibomet. Pab ua kom cov ntshav qab zib thiab ntshav hauv lub cev sib luag. 20 ntsiav tshuaj ntawm cov tshuaj tuaj yeem raug yuav rau 345 rubles.
Glidiab. Cov tshuaj yeeb tshuaj yog gliclazide. Tsub kom cov ntaub so ntswg rhiab rau insulin. Cov sib txawv hauv cov nqi pheej yig thiab ua haujlwm zoo. Cov tshuaj yuav tuaj yeem yuav rau 128 rubles. - 60 ntsiav tshuaj.
Gliformin. Cov tshuaj phiv tshuaj yog metformin. Nws muaj ob peb phiv. Nqe - 126 rubles rau 60 ntsiav tshuaj.
Ntsia hauv qab. Muaj cov tshuaj metformin hydrochloride. Tsis txhawb kev tsim cov tshuaj insulin. Nws tuaj yeem muas 127 rubles.
Galvus. Txhim kho glycemic tswj. Nws yog qhov nyuaj nrhiav tau hauv khw muag tshuaj Lavxias, thiab hauv particular St.
Glucophage Ntev. Tib yam li yav dhau los counterpart. Qhov txawv tsuas yog kev maj mam tso tawm ntawm cov tshuaj yeeb dej caw. Nqe - 279 rub.
Lawj xeeb. Txo cov piam thaj ntau hauv cov kab mob ncig. Siv rau qhov tsis muaj peev xwm ua kom tsis muaj teeb meem ntawm cov khoom noj khoom haus. Tus nqi rau 30 ntsiav tshuaj yog 296 rubles.
Maninil. Muaj cov tshuaj glibenclamide. Nws tuaj yeem raug siv ua ib feem ntawm kev kho mob monotherapy. Tus nqi yog 118 rubles. rau 120 ntsiav tshuaj.
Metformin. Nws ua rau cov txheej txheem ntawm kev tsim glycogen. Ua rau cov leeg khov kho tuaj. Muag los ntawm cov tshuaj. Nqe - 103 rubles. rau 60 ntsiav tshuaj.
Siofor. Nws muaj cov metformin. Txo cov piam thaj ntau lawm, ua kom cov insulin ntau ntxiv. Nws tuaj yeem siv rau kev kho mob hlwb. Tus nqi nruab nrab yog 244 rubles.
Rau menyuam yaus. Txo cov gluconeogenesis thiab ua rau cov nqaij mos rhiab ua rau cov tshuaj insulin. Nws tsis pab txhawb kev tsim cov tshuaj insulin. Koj tuaj yeem yuav rau 85 rubles.
Januvius. Muaj cov tshuaj active sitagliptin. Nws tuaj yeem raug siv ua ib feem ntawm kev kho mob monotherapy. Nrhiav rau 1594 rubles.

Cov no tau nrov tshaj plaws Galvus thiab Galvus Met analogues. Txwv tsis pub muaj kev ywj pheej hloov ntawm ib cov yeeb tshuaj mus rau lwm qhov tsis pub Kev sab laj nrog tus kws kho mob tshwj xeeb yog xav tau.

Noj ntau dhau

Kev siv tshuaj ntau dhau ntawm vildagliptin tshwm sim thaum txoj kev noj ntau dua tau nce rau 0.4 g. Qhov no, pom hauv qab no:

Mob hauv cov leeg.
Lub siab hlis ntuj.
O o.

Kev kho mob muaj nyob rau hauv qhov tsis lees ntawm cov tshuaj ib pliag. Kev lim ntshav yog kev xyaum siv tsis tau. Tsis tas li, kev kho mob tuaj yeem tshwm sim.

Kev noj tshuaj ntau tshaj ntawm metformin tshwm sim nrog kev siv ntau dua 50 g ntawm qhov chaw ntawd. Hauv qhov xwm txheej no, ua rau pom kev ntshav siab ntshav qab zib thiab kab mob lactic acidosis. Cov tsos mob tseem ceeb:

Zawv plab
Tsawg kub.
Mob hauv plab.

Hauv cov xwm txheej zoo li no, nws yog ib qho tsim nyog kom tso tseg cov tshuaj. Rau kev kho mob, kho mob hemodialysis siv.

Xav txog cov kev tshuaj xyuas uas cov neeg tawm mus txog Galvus lossis Galvus Met:

Galvus tshuaj xyuas hais tias qhov no yog lub sijhawm zoo tswj tau qab zib. Cov neeg siv tshuaj yaj yeeb pom nws cov txiaj ntsig zoo.

Sab sij huam

Feem ntau, galvus yog ib qho tshuaj siv uas muaj kev nyab xeeb heev. Cov kev tshawb fawb lees paub tias kev kho mob ntshav qab zib hom 2 nrog cov tshuaj no tsis ua rau muaj kev pheej hmoo ntawm cov kab mob plawv, kab mob siab, lossis lub cev tsis muaj zog. Noj cov tshuaj vildagliptin (cov tshuaj ua kom nquag plias hauv galvus ntsiav tshuaj) tsis nce qhov hnyav hauv lub cev.

Piv nrog cov tsoos ntshav hauv cov ntshav qis dua, nrog rau cov placebo, galvus tsis muaj kev pheej hmoo rau ntawm pancreatitis. Feem ntau ntawm nws cov kev mob tshwm sim yog mob me me thiab ib ntus. Tsis tshua pom muaj: