Kev piav qhia thiab cov lus qhia rau kev siv tshuaj Berlition

Berlition muaj nyob hauv cov ntawv hauv qab no:

Mloog zoo rau kev daws teeb meem rau infusion: greenish-daj, pob tshab (Berlition 300: 12 ml hauv ampoules iav tsaus, 5, 10 lossis 20 ampoules hauv cardboard cov tais, 1 lub tais hauv ib pob ntawm cardboard, Berlition 600: 24 ml hauv tsaus nti iav ampoules, 5 ampoules hauv hnab yas, 1 pallet hauv pob ntawv los qhia),
Cov tshuaj pleev xim rau cov yeeb yaj kiab: puag ncig, biconvex, ntawm ib sab - muaj kev pheej hmoo, xim daj ntseg daj, ntawm ntu ntoo khaub lig qhov chaw tsis sib luag yog pom (10 pcs. Hauv cov hlwv, 3,6.10 hlwv hauv lub thawv ntawv).

Lub ntsiab ua pa tseem ceeb yog thioctic acid:

Hauv 1 ampoule ntawm mloog zoo - 300 mg lossis 600 mg,
Hauv 1 ntsiav tshuaj - 300 mg.

Cov Tshuaj Hauv Tshuaj

Thioctic (alpha lipoic) acid yog qhov tshuaj tiv thaiv kab mob tsis txaus ntawm cov ncaj qha (dawb radical binding) thiab ncaj qha kev ua. Nws zwm rau cov pab pawg coenzymes muab kev koom tes hauv qhov decarboxylation ntawm alpha-keto acids. Cov kev sib xyaw no pab txo qis ntshav qabzib thiab nce siab glycogen concentration, txo cov tshuaj insulin tsis kam, koom nrog kev tswj hwm ntawm lipid thiab carbohydrate metabolism, thiab tseem ua rau cov roj metabolism hauv lub siab.

Txij li thaum thioctic acid muaj cov khoom siv antioxidant, nws tiv thaiv cov hlwb los ntawm kev puas tsuaj los ntawm lawv cov khoom tawg, inhibits qhov kawg ntawm cov khoom kawg ntawm glycosylation nce qib ntawm cov protein hauv cov hlab ntsha, uas nrog ntshav qab zib, txhim kho endoneural ntshav txaus thiab microcirculation, thiab nce lub physiological concentration ntawm glutathione antioxidant. Kev muab cov ntshav qabzib hauv cov ntshav plasma tsawg dua, kev cuam tshuam ntawm Berlition cuam tshuam rau lwm yam tshuaj qabzib nyob rau hauv cov ntshav qab zib mellitus, ua kom tsis txhob muaj ntau cov kev txuam nrog pathological metabolites hauv daim ntawv ntawm polyols thiab, vim li ntawd, txo edema ntawm cov leeg.

Thioctic acid muaj kev koom tes hauv cov metabolism hauv cov rog, uas ua rau kev nce ntxiv ntawm biosynthesis ntawm phospholipids, tshwj xeeb hauv phosphoinositides, uas ua rau lub cev tsis sib xws ntawm cov qauv puas ntawm cov qog cell. Tsis tas li, cov tshuaj muaj zog txhim kho kev sib txuas ntawm cov hlab ntaws ua rau lub zog thiab lub zog hauv lub cev, tso cai rau koj kom tshem tau cov tshuaj lom ntawm cov dej cawv metabolites (pyruvic acid, acetaldehyde). Thioctic acid tiv thaiv kev tsim cov ntau dhau ntawm cov lwg me me ntawm cov pa oxygen dawb, tshem tawm ischemia thiab endoneural hypoxia, txo cov tsos mob ntawm polyneuropathy, qhia nyob rau hauv txoj kev xav loog, mob lossis hlawv hauv nqua, zoo li hauv paresthesias. Yog li, cov tshuaj no hloov kho cov lipid metabolism thiab pom los ntawm cov nyhuv neurotrophic thiab antioxidant. Kev siv thioctic acid nyob rau hauv daim ntawv ntawm ethylene diamine ntsev coj ua rau txo qis hauv qhov hnyav ntawm qhov tshwm sim tsis zoo.

Cov Tshuaj Pharmacokinetics

Nrog txoj kev tswj hwm ntawm Berlition, qhov siab tshaj plaws ntawm cov tshuaj yeeb dej caw hauv cov ntshav ntshav yog kwv yees li 20 μg / ml 30 feeb tom qab infusion, thiab thaj chaw hauv qab qhov nkhaus-sijhawm nkhaus yog kwv yees li 5 μg / h / ml. Thioctic acid muaj qhov ua tau “ua ntej dhau” lub siab los ntawm daim siab. Nws cov khoom noj ua ke tau tsim vim kev sib txuas thiab oxidation ntawm lub saw sab. Qhov ntim ntawm kev faib tawm yog kwv yees li 450 ml / kg. Kev tshem ntshav tag nrho yog 10-15 ml / min / kg. Thioctic acid yog tawm dhau los ntawm lub raum (80-90%), feem ntau yog hauv daim ntawv ntawm metabolites. Ib nrab-lub neej nyob nrog li 25 feeb.

Cov lus qhia rau kev siv Berlition: txoj kev thiab ntau npaum li cas

Cov tshuaj feem ntau noj ib hnub ib zaug, thaum sawv ntxov, ib nrab teev ua ntej noj tshais. Cov ntsiav tshuaj Berlition tsis tuaj yeem zom thiab zuaj. Cov koob tshuaj txhua hnub rau cov neeg laus yog 600 mg (2 ntsiav tshuaj).

Cov tshuaj nyob rau hauv daim ntawv ntawm mloog zoo, diluted nrog 0.9% sodium tshuaj dawb tov, yog muab tshuaj dropwise nyob rau hauv 250 ml rau ib nrab ib teev. Cov koob tshuaj txhua hnub rau cov neeg mob laus yog 300-600 mg. Cov lus qhia ntawm Berlition tso leeg yog feem ntau 2-4 lub lis piam, tom qab ntawd tus neeg mob hloov mus rau cov tshuaj ntawm qhov ncauj.

Cov lus qhia tshwj xeeb

Lub sijhawm kho mob, koj yuav tsum tso tseg txoj kev haus cawv muaj cawv, txij li thaum ethanol txo cov nyhuv thioctic acid.

Cov neeg mob ntshav qab zib yuav tsum saib xyuas lawv cov ntshav qab zib kom mus tas li.

Noj cov khoom noj siv mis, thiab ua li noj magnesium thiab hlau npaj thaum kho yuav tsum noj thaum tav su.

Nrog rau kev sib koom tes ntawm cov tshuaj nrog cov tshuaj tiv thaiv kab mob qhov ncauj thiab insulin, cov nyhuv ntawm tom kawg yog kho kom zoo.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Kev tshawb nrhiav txog kev cuam tshuam ntawm Berlition ntawm kev ceev ntawm lub hlwb kev xav thiab muaj peev xwm pom thiab ntsuas sai sai cov xwm txheej tsis tau coj los ua, yog li, thaum kho nrog tshuaj, kev saib xyuas tshwj xeeb yuav tsum tau coj thaum tsav tsheb thiab ua cov haujlwm txaus ntshai uas xav tau kev nce siab ntawm kev mloog thiab xav tau.

Yeeb tshuaj sib cuam tshuam

Txij li kev tsim cov chelate nyuaj ntawm thioctic acid nrog cov hlau yog qhov ua tau, Berlition yuav tsum tsis txhob raug sau ua ke nrog cov hlau npaj. Kev sib xyaw ntawm cov tshuaj nrog cisplatin txo cov kev ua tau zoo ntawm kev tom kawg.

Thioctic acid ua ke nrog cov suab thaj molecules, tsim cov kev sib txuas ua ke uas tsis muaj peev xwm yaj tau. Berlition raug txwv tsis pub siv tawm tsam tom qab ntawm kev kho mob nrog Ringer txoj kev daws teeb meem, dextrose, fructose thiab qabzib cov kev daws teeb meem, nrog rau cov kev daws teebmeem nrog disulfide thiab SH-pawg. Cov tshuaj pab txhim kho cov nyhuv hypoglycemic ntawm insulin thiab lwm yam tshuaj hypoglycemic nrog lawv siv ua ke. Ethanol ho tsis muaj zog kho qhov ua tau zoo ntawm Berlition.

Cov qauv ntawm cov qauv ntawm Berlition yog Espa-Lipon, Oktolipen, Thiogamma, Lipothioxon, Thiolipon thiab Neuroleipone.

Kev txheeb xyuas Berlition

Raws li kev tshuaj xyuas, Berlition 300 thiab Berlition 600 hauv txhua daim ntawv tshuaj (ntsiav tshuaj, txhaj tshuaj) feem ntau siv los kho cov neeg mob ntshav qab zib mellitus thiab mob siab pathologies. Ntxiv mus, cov tshuaj pom tau tias zoo heev tsis tsuas yog nyob hauv cov neeg mob, tab sis kuj tseem nyob hauv kev voj voog kho mob. Hauv 95% ntawm cov neeg mob, kev kho nrog Berlition muab cov txiaj ntsig zoo, thiab qhov tshwm sim tsis zoo yog xyaum qhaj. Tab sis nws yuav tsum tau coj mus rau hauv tus account tias tsuas yog tus kws kho mob tshwj xeeb yuav tsum tau sau tshuaj thiab tsim kho tshuaj.

Cov Yuav Tsum Muaj

Raws li cov lus qhia, Berlition yog contraindicated hauv:

Cov tib neeg tsis qaug rau alpha lipoic acid los yog ntu ntawm cov tshuaj,
Tsis txog 18 xyoo
Cev xeeb tub thiab lactation,

Berlition 300 Qhov ncauj ntsiav tshuaj yog contraindicated rau kev kho mob ntawm cov neeg mob kev txom nyem los ntawm malabsorption ntawm qabzib-galactose, tsis muaj lactase thiab galactosemia. Berlition tsiav tshuaj tsis qhia rau cov neeg mob uas muaj fructose intolerance.

Hauv kev siv Berlition, kev ceev faj yuav tsum tau ua kom nquag muaj ntshav qab zib. Yog tias yuav tsum siv cov tshuaj rau pawg neeg mob no, glycemia yuav tsum tau soj ntsuam kom tsis tu ncua.

Tsuas tshuaj thiab tswj hwm

Berlition nyob rau hauv cov ntsiav tshuaj thiab tshuaj ntsiav yog kho sab hauv. Cov tshuaj tsis pom zoo muab zom lossis zom thaum siv. Qhov tshuaj txhua hnub yog noj ib hnub ib zaug, txog ib nrab teev ua ntej noj ib pluag mov. Txhawm rau kom ua tiav qhov ua tau zoo tshaj plaws, nws raug nquahu kom nruj thiab ua raws li cov cai ntawm kev tso cai nkag mus hauv cov lus qhia rau Berlition.

Raws li txoj cai, lub sijhawm tiv thaiv nrog Berlition yog lub sijhawm ntev. Lub sijhawm sijhawm ntawm kev pub nkag yog txiav txim siab ntawm tus kws khomob tau koom. Dosage ntawm cov tshuaj:

Nrog tus mob ntshav qab zib polyneuropathy - 600 mg ib hnub twg,
Nrog rau cov kab mob siab - 600-1200 mg ntawm thioctic acid ib hnub.

Hauv cov xwm txheej loj, nws raug nquahu los sau ntawv rau tus neeg mob Berlition hauv daim ntawv ntawm txoj kev daws rau infusion.

Berlition nyob rau hauv daim ntawv ntawm mloog zoo rau kev npaj ntawm kev daws rau kev lis ntshav yog siv rau kev tswj hwm dej khov. Raws li cov tshuaj hnyav, tsuas yog siv 0.9% sodium chloride yuav tsum tau siv, 250 ml ntawm cov tshuaj tov tau npaj rau ib nrab ib teev. Dosage ntawm cov tshuaj:

Nrog rau daim ntawv hnyav ntawm cov mob ntshav qab zib polyneuropathy - 300-600 mg ntawm Berlition,
Hauv cov kab mob siab heev - 600-1200 mg ntawm thioctic acid ib hnub.

Cov ntawv foos niam txiv yog npaj rau kev kho mob, lub sijhawm yog 0.5-1 hlis, tom qab ntawd, raws li txoj cai, tus neeg mob pauv mus rau cov ntsiav tshuaj lossis tshuaj ntsiav Berlition.

Sab sij huam

Kev siv Berlition tuaj yeem ua rau cov kev mob tshwm sim hauv qab no:

Lub plab zom mov: ntuav thiab xeev siab, cem quav lossis zawv plab, hloov pauv ntawm saj, cov tsos mob dyspeptic,
Cov leeg ntu thiab nruab nrab hauv cov leeg hlwb: tom qab txhaj tshuaj nrawm nrawm mus rau txoj hlab ntshav leeg, qaug dab peg, zoo li qhov hnyav nyob hauv taub hau, diplopia,
Lub plawv mob: hyperemia ntawm lub ntsej muag thiab lub cev sab saud, tachycardia, zoo nkaus li zawm thiab mob hauv siab,
Ua xua: tawv nqaij ua pob khaus, khaus, eczema, urticaria.

Qee zaum, nrog kev siv tshuaj intravenous ntawm qib siab ntawm cov tshuaj, anaphylactic kev poob siab tuaj yeem tsim kho. Tsis tas li, txoj kev txhim kho mob taub hau, kiv taub hau, pom kev tsis hnov lus, ua pa luv, purpura thiab thrombocytopenia tsis tau txiav txim siab.

Hauv cov neeg mob uas muaj mob polyneuropathy nyob rau theem pib ntawm kev kho nrog Berlition, qhov nce ntawm paresthesia yog ua tau, nrog los ntawm kev xav ntawm "goose bumps".

Cov lus thiab cov xwm txheej ntawm kev cia

Raws li cov lus qhia, Berlition yuav tsum muab cia rau hauv qhov chaw qhuav, tsaus thiab txias.

Cov concentrate rau kev daws teeb meem rau txoj kev lis ntshav muaj lub txee lub neej ntawm 3 xyoo. Hauv daim foos tiav, cov tshuaj tov rau Txoj kev lis ntshav tsis tuaj yeem khaws cia ntev dua 6 teev (muab lub raj mis muaj kev tiv thaiv los ntawm lub hnub).

Berlition 300 Qhov ncauj ntsiav tshuaj muaj lub neej txee ntawm 2 xyoo, Berlition 300 tsiav tshuaj - 3 xyoo, Berlition 600 - 2.5 xyoo.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.