Liptonorm - kev qhia ua qauv rau kev siv > Kev khomob thiab kev tiv thaiv

Kev sau npe: P No. 016155/01

Lub npe kev lag luam ntawm cov tshuaj: Liptonorm®

Lub Npe Tsis Muaj Npe International: Atorvastatin

Dosage daim ntawv: coated ntsiav tshuaj

Muaj pes tsawg leeg

Txhua cov ntsiav tshuaj coated muaj:
Yam khoom muaj sia - Atorvastatin calcium, hauv ib qho nyiaj npaum li 10 mg thiab 20 mg ntawm atorvastatin
Cov muaj tswv yim: calcium carbonate, microcrystalline cellulose, lactose, kaum ob 80, hydroxypropyl cellulose, crossscarmellose, magnesium stearate, hydroxypropyl methyl cellulose, titanium dioxide, polyethylene glycol.

Kev piav qhia

Dawb, puag ncig, biconvex zaj duab xis-coated ntsiav tshuaj. Thaum lub sijhawm so, cov ntsiav tshuaj muaj xim dawb lossis yuav luag dawb.

Cov tshuaj pab pawg kho mob: lipid-txo tus neeg sawv cev - tshuaj tiv thaiv ntawm HMG CoA reductase.

ATX CODE S10AA05

Cov chaw muag tshuaj

Cov Tshuaj Hauv Tshuaj
Hypolipidemic tus neeg sawv cev los ntawm pawg statins. Lub tshuab tseem ceeb ntawm kev ua ntawm atorvastatin yog qhov inhibition ntawm kev ua ntawm 3-hydroxy-3-methylglutaryl coenzyme A - (HMG-CoA) reductase, ib qho enzyme uas catalyzes hloov dua siab tshiab ntawm HMG-CoA rau mevalonic acid. Qhov kev hloov pauv no yog ib qho ntawm thawj kauj ruam ntawm kev sib tshooj hauv cov roj (cholesterol) coj los ua ke hauv lub cev. Kev tsuj ntawm atorvastatin roj synthesis ua rau cov tshuaj tiv thaiv muaj zog ntawm LDL receptors (lipoproteins tsawg ntom) hauv lub siab, zoo li hauv cov ntaub so ntswg tshwj xeeb. Cov receptors khi LDL cov roj ntsha thiab tshem tawm cov ntshav ntshav, uas ua rau cov roj cholesterol LDL tsawg hauv cov ntshav.
Cov nyhuv antisclerotic ntawm atorvastatin yog lub txiaj ntsig ntawm cov nyhuv ntawm cov tshuaj rau ntawm phab ntsa ntawm cov hlab ntsha thiab cov ntshav sib xyaw ua ke. Cov tshuaj inhibits lub synthesis ntawm isoprenoids, uas yog yam loj hlob ntawm cov cell ntawm lub puab ntawm cov hlab ntsha. Nyob hauv kev cuam tshuam ntawm atorvastatin, endothelium-ywj pheej nthuav cov hlab ntshav txhim kho. Atorvastatin txo qis cov roj cholesterol, cov lipoproteins tsawg ntom, apolipoprotein B, triglycerides. Ua rau muaj kev nce qib hauv HDL cov roj (txhaws ntau heev dipoproteins) thiab apolipoprotein A.
Kev txiav txim ntawm cov tshuaj, raws li txoj cai, txhim kho tom qab 2 lub lis piam ntawm kev tswj hwm, thiab cov txiaj ntsig siab tshaj plaws tau tiav tom qab plaub lub lis piam.

Cov Tshuaj Pharmacokinetics
Kev tshem tawm yog qhov siab. Lub sijhawm nce mus txog qhov siab tshaj plaws yog 1-2 teev, qhov siab tshaj plaws hauv cov poj niam yog 20% siab dua, AUC (thaj chaw hauv qab txoj kab nkhaus) yog 10% qis dua, qhov siab tshaj plaws hauv cov neeg mob haus cawv ntau yog 16 zaug, AUC yog 11 zaug siab dua li ib txwm. Khoom noj khoom haus me ntsis txo qhov nrawm thiab lub sijhawm nqus ntawm kev nqus ntawm cov tshuaj (los ntawm 25% thiab 9%, feem), txawm li cas los xij, txo cov roj cholesterol LDL zoo ib yam li cov tshuaj atorvastatin tsis muaj zaub mov. Qhov kev nkag siab ntawm atorvastatin thaum thov thaum yav tsaus ntuj yog qis dua thaum sawv ntxov (kwv yees li 30%). Txoj kab sib txuas ntawm qhov txheeb ze ntawm qhov nqus ntawm qhov nqus thiab qhov tshuaj ntawm cov tshuaj tau qhia tawm.
Bioavailability - 14%, lub cev tsis muaj zog ntawm cov kev txwv tsis pub tiv thaiv HMG-CoA reductase - 30%. Kev siv lub cev tsis tshua muaj txiaj ntsig zoo yog vim muaj cov kab mob presystemic hauv lub plab zom mov thiab txoj hnyuv "thaum pib tso" los ntawm lub siab.
Qhov ntsuas nruab nrab ntawm kev faib tawm yog 381 l, kev sib txuas nrog cov ntshav plasma protein yog 98%.
Nws yog metabolized feem ntau hauv daim siab nyob rau hauv kev txiav txim ntawm cytochrome P450 CYP3A4, CYP3A5 thiab CYP3A7 nrog kev tsim cov pharmacologically nquag metabolites (ortho- thiab para-hydroxylated derivatives, beta-oxidation khoom).
Qhov cuam tshuam ntawm cov tshuaj tawm tsam HMG-CoA reductase yog kwv yees li 70% txiav txim siab los ntawm kev ua si ntawm cov roj ntsha hloov mus.
Nws yog cov kua hauv cov kua tsib tom qab cov kab mob hepatic thiab / lossis extrahepatic metabolism (tsis ua mob hnyav nkag mus hauv qhov hnyav).
Ib nrab-lub neej yog 14 teev .Tes kev tiv thaiv kev ua si tiv thaiv HMG-CoA reductase tseem muaj txog li 20-30 teev, vim muaj cov metabolites nquag. Tsawg dua 2% ntawm kev noj tshuaj hauv qhov ncauj yog txiav txim siab nyob rau hauv cov zis.
Nws tsis yog nyob hauv tus kab mob hemodialysis.

Kev ntsuas rau siv

Thawj hypercholesterolemia, sib xyaw hyperlipidemia, heterozygous thiab homozygous tsev neeg hypercholesterolemia (raws li ntxiv rau kev noj haus).

Hypersensitivity rau ib qho ntawm cov tshuaj, kab mob siab hauv lub cev nquag (nrog rau kev mob siab ntev, mob ntsig txog tus mob ntsig txog cawv), nce kev ua haujlwm ntawm hepatic transaminases (ntau dua 3 zaug piv nrog rau qhov txwv qis ntawm qhov tsis suav) ntawm cov keeb kwm tsis paub, daim siab ua haujlwm tsis zoo (mob hnyav A thiab B raws li Tus Txheej Txheem Child-Pyug), mob ntshav ntawm txoj kev mob ntsws, mob cev xeeb tub, lactation, muaj hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim).

Nrog saib xyuas: keeb kwm ntawm kab mob siab, mob ntshav qis tsis txaus, tshuaj endocrine thiab metabolic ntshaus siab, kev haus dej cawv, mob ntshav tawm ntshav, mob hnyav heev (mob sepsis), mob chua leeg, tsis muaj kev phais mob ntev ntev, raug mob.

Tsuas tshuaj thiab tswj hwm

Ua ntej pib kho Liptonorm, tus neeg mob yuav tsum pauv mus rau qhov kev noj haus uas ua kom cov ntshav lipids tsawg dua, uas yuav tsum tau pom thaum lub sijhawm kho cov tshuaj.
Sab hauv, siv sijhawm txhua hnub ntawm lub hnub (tab sis tib lub sijhawm), tsis hais txog ntawm kev noj zaub mov.
Qhov pom zoo kom pib noj yog 10 mg ib hnub ib zaug. Tom ntej no, cov koob tshuaj tau xaiv ib tus zuj zus nyob ntawm cov roj (cholesterol) hauv cov ntshav - LDL. Cov koob tshuaj yuav tsum tau hloov nrog lub caij nyoog tsawg kawg yog 4 lub lis piam. Qhov tshuaj ntau tshaj txhua hnub yog 80 mg hauv 1 koob tshuaj.

Thawj (kab mob heterozygous muaj keeb thiab polygenic) hypercholesterolemia (hom IIa) thiab sib xyaw hyperlipidemia (hom IIb)
Kev kho mob pib nrog kev pom zoo kom pib lub koob tshuaj, uas tau nce ntxiv tom qab 4 lub lis piam ntawm kev kho, nyob ntawm tus neeg mob cov lus teb. Qhov nyiaj pab ntau tshaj txhua hnub yog 80 mg.

Homozygous muaj keeb tiv thaiv hypercholesterolemia
Cov koob tshuaj ntau yog tib yam li nrog lwm hom hyperlipidemia. Thawj koob tshuaj tau xaiv ib tus zuj zus nyob ntawm qhov mob hnyav ntawm tus kab mob. Hauv feem ntau cov neeg mob homozygous kab mob hypercholesterolemia, cov txiaj ntsig zoo tau pom thaum siv cov tshuaj hauv ib hnub ntawm 80 mg (ib zaug).

Hauv cov neeg mob uas lub raum tsis ua haujlwm thiab hauv cov neeg laus, kev kho mob Liptonorm tsis tas yuav tsum tau txhaj.
Hauv cov neeg mob uas lub siab tsis ua hauj lwm zoo, ceev faj yuav tsum ua kom muaj kev sib txuas nrog kev ua kom qeeb ntawm kev tshem tawm cov tshuaj tawm hauv lub cev. Cov chaw kuaj mob thiab kuaj ntsuas yuav tsum tau ua tib zoo saib, thiab yog tias pom muaj cov kab mob loj hloov pauv, cov koob tshuaj yuav tsum raug txo lossis txoj kev kho yuav tsum tau txiav tawm.

Los ntawm lub hauv nruab nrab hauv lub paj hlwb: nyob rau hauv ntau dua 2% ntawm cov neeg mob - insomnia, kiv taub hau, hauv tsawg dua 2% ntawm cov neeg mob - mob taub hau, asthenic syndrome, malaise, tsaug zog, npau suav phem, amnesia, paresthesia, peripheral neuropathy, amnesia, kev xav lability, ataxia, lub ntsej muag hlab ntsha, hyperkinesis, kev nyuaj siab hyperesthesia, ploj tsis nco qab.
Ntawm qhov txhia chaw: amblyopia, lub suab nrov hauv lub pob ntseg, lub ntsej muag ntawm lub qhov muag, cuam tshuam ntawm kev pab, hemorrhage nyob rau hauv lub qhov muag, lag ntseg, lub ntsej muag daj, parosmia, ploj ntawm saj, perversion ntawm saj.
Los ntawm cov kab mob plawv: nyob rau hauv ntau dua 2% ntawm cov neeg mob - mob hauv siab, tsawg dua 2% - palpitations, vasodilation, migraines, postural hypotension, ntshav siab, phlebitis, arrhythmia, angina pectoris.
Los ntawm cov kab ke hemopoietic: anemia, lymphadenopathy, thrombocytopenia.
Los ntawm tus txheej txheem ua pa: nyob rau hauv ntau dua 2% ntawm cov neeg mob - mob ntsws, mob ntsws, tsawg dua 2% ntawm cov neeg mob - mob ntsws, mob qa, mob ntsws, ntsws.
Los ntawm lub plab zom mov: nyob rau hauv ntau dua 2% ntawm cov neeg mob - xeev siab, kub siab, cem quav lossis mob raws plab, mob plab, mob plab, mob plab, mob ntshav qab zib lossis nce siab, qhov ncauj qhuav, ua rau lub plab, mob plab, ntuav, stomatitis, esophagitis, glossitis, voos thiab mob rau lub plab ntawm cov nqaij mos ntawm cov kab noj hniav. qhov ncauj, mob ncauj plab, kab mob siab, mob plab, mob plab, mob hlwb, mob plab, mob plab, mob txhaws qa, tawv nqaij txhav, ua rau lub siab ua haujlwm tsis zoo, tawm ntshav ntawm lub qhov ncauj, melena, cov pos hniav los ntshav, tenesmus.
Los ntawm cov leeg musculoskeletal: nyob rau hauv ntau dua 2% ntawm cov neeg mob - mob caj dab, nyob hauv tsawg dua 2% ntawm cov neeg mob - mob caj dab, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, leeg hypertonicity, koom tes sib cog lus.
Los ntawm genitourinary system: nyob rau hauv ntau dua 2% ntawm cov neeg mob - mob urogenital, peripheral edema, nyob rau hauv tsawg dua 2% ntawm cov neeg mob - dysuria (suav nrog pollakiuria, nocturia, tso zis tsis tuaj yeem lossis tso zis, yuav tsum tso zis), nephritis, hematuria, ntshav tawm ntawm lub paum, nephrourolithiasis, metrorrhagia, epididymitis, txo qis libido, tsis muaj zog, tsis muaj peev xwm nthuav tawm.
Ntawm feem ntawm daim tawv nqaij: tsawg dua 2% ntawm cov neeg mob - alopecia, xeroderma, nce tawm hws, eczema, seborrhea, ecchymosis, petechiae.
Kev tsis haum tshuaj: nyob rau hauv tsawg dua 2% ntawm cov neeg mob - khaus, tawm pob ntawm daim tawv nqaij, hu rau dermatitis, tsis tshua muaj - urticaria, angioedema, ntsej muag tawv nqaij, photosensitivity, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, lom ua paug epidermal necrolysis (Lyell's syndrome).
Kev ntsuas ntsuas: tsawg dua 2% ntawm cov neeg mob yog hyperglycemia, hypoglycemia, nce ntxiv ntawm serum creatine phosphokinase, alkaline phosphatase, albuminuria, nce alanine aminotransferase (ALT) lossis aspartic aminotransferase.
Lwm yam: tsawg dua 2% ntawm cov neeg mob - qhov hnyav nce, gynecomastia, mastodynia, exacerbation ntawm gout.

Noj ntau dhau

Kev Kho Mob: tsis muaj ib qho tshuaj tua kab mob tshwj xeeb. Kev kho mob raws qab. Lawv coj kev ntsuas los tswj lub luag haujlwm tseem ceeb hauv lub cev thiab ntsuas kom tiv thaiv tsis txhob nqus ntxiv ntawm cov tshuaj: pais plab lav, kev noj cov pa hluav taws. Hemodialysis tsis muaj txiaj ntsig.
Yog tias muaj cov cim qhia thiab muaj cov kev pheej hmoo txaus rau kev txhim kho ntawm lub raum tsis ua haujlwm vim rhabdomyolysis (qhov tsis tshua tab sis muaj mob tshwm sim loj heev), cov tshuaj yuav tsum tau txiav tawm tam sim ntawd.
Txij li thaum atorvastatin feem ntau cuam tshuam nrog cov ntshav plasma protein, hemodialysis yog qhov kev ua haujlwm tsis muaj txiaj ntsig tshem tawm cov tshuaj no ntawm lub cev.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog rau kev tswj hwm tib lub sijhawm ntawm cyclosporine, fibrates, erythromycin, clarithromycin, immunosuppressive, antifungal tshuaj (cuam tshuam nrog azoles) thiab nicotinamide, cov tshuaj atorvastatin hauv cov ntshav ntshav (thiab muaj kev pheej hmoo ntawm myopathy) nce. Antacids txo qhov tshuaj nyob ntawm 35% (cov nyhuv ntawm LDL cov cholesterol tsis hloov).
Qhov kev siv ntau tshaj tawm ntawm atorvastatin nrog protease inhibitors hu ua CYP3A4 cytochrome P450 inhibitors yog los ntawm kev nce ntxiv hauv plasma ntau ntawm atorvastatin.
Thaum siv digoxin sib xyaw nrog atorvastatin ntawm ib koob ntawm 80 mg / hnub, kev ua haujlwm ntawm digoxin nce ntxiv txog li 20%.
Tsub kom cov siab ntxiv 20% (thaum kho nrog atorvastatin ntawm ib koob ntawm 80 mg / hnub) ntawm qhov ncauj txwv tsis pub muaj norethindrone thiab ethinyl estradiol.
Cov lipid-txo cov nyhuv ntawm kev sib xyaw nrog colestipol yog qhov zoo dua rau qhov ntawd rau txhua cov tshuaj ib tus zuj zus.
Nrog rau kev tswj hwm tib lub sijhawm nrog warfarin, lub sijhawm prothrombin txo qis hauv thawj hnub, txawm li cas los xij, tom qab 15 hnub, qhov ntsuas no tseem ceeb. Hauv qhov no, cov neeg mob noj atorvastatin nrog warfarin yuav tsum muaj ntau dua li ib txwm siv los tswj lub sijhawm prothrombin.
Kev siv cov kua txiv kab ntxwv qaub thaum kho nrog atorvastatin tuaj yeem ua rau nce ntxiv ntawm cov tshuaj nyob rau hauv cov ntshav ntshav. Hauv qhov no, cov neeg mob noj cov tshuaj yuav tsum tsis txhob haus cov kua txiv no.

Cov lus qhia tshwj xeeb

Lub siab ua haujlwm tsis zoo
Kev siv HMG-CoA reductase inhibitors kom txo cov ntshav lipids tuaj yeem ua rau muaj kev hloov pauv hauv cov khoom siv biochemical uas muaj kev cuam tshuam ntawm daim siab ua haujlwm.
Lub siab ua haujlwm yuav tsum tau saib xyuas ua ntej kev kho mob, 6 lub lis piam, 12 lub lis piam tom qab pib Liptonorm thiab tom qab txhua koob nce, thiab tsis tseg, piv txwv li, txhua 6 lub hlis. Kev hloov pauv ntawm cov kev ua ntawm daim siab enzymes feem ntau pom thaum thawj peb lub hlis tom qab pib noj Liptonorm. Cov neeg mob uas muaj qhov nce ntawm transaminase yuav tsum tau saib xyuas kom txog thaum lub enzyme rov qab los rau hauv qub. Nyob rau hauv kev tshwm sim uas qhov tseem ceeb ntawm alanine aminotransferase (ALT) lossis aspartic aminotransferase (AST) yog ntau tshaj 3 zaug ntawm theem ntawm cov kev txwv sab sauv, nws raug nquahu kom txo qhov koob tshuaj Liptonorm lossis tsum tsis kho.

Hlab pob txha leeg
Cov neeg mob uas mob myalgia, mob nkees lossis leeg tsis muaj zog thiab / lossis ntau qhov tseem ceeb ntawm KFK sawv cev rau cov pab pawg muaj kev pheej hmoo rau kev txhim kho myopathy (txhais tau tias mob nqaij nrog qhov nce ntxiv hauv KFK ntau dua 10 lub sij hawm piv nrog rau lub txheej txwv sab sauv ntawm ib txwm).
Thaum sau tshuaj kho kev sib txuas ua ke ntawm Liptonorm nrog cyclosporine, derivatives ntawm fibric acid, erythromycin, clarithromycin, immunosuppressants, thiab tshuaj tua kab mob ntawm tus qauv azole, nrog rau cov koob tshuaj ntawm niacin uas ua rau txo qis lipid, nws yog qhov tsim nyog los sib piv cov txiaj ntsig muaj txiaj ntsig thiab qib kev pheej hmoo nrog kev kho mob no thiab saib xyuas cov neeg mob nws cov cim lossis cov tsos mob ntawm cov leeg mob, leeg nkees lossis tsis muaj zog tshwm sim, tshwj xeeb tshaj yog nyob rau thawj lub hlis ntawm kev kho mob thiab nrog qhov nce hauv koob tshuaj ntawm ib qho twg Reparata.

Kev kho Liptonorm yuav tsum tau muab tshem tawm ib ntus los sis txiav tsis ua haujlwm vim kev loj hlob ntawm qhov mob hnyav uas yuav tshwm sim los ntawm myopathy, zoo li yog tias muaj kev pheej hmoo rau kev loj hlob ntawm kev mob raum tsis zoo vim tias mob rhabdomyolysis (piv txwv li mob hnyav, mob ntshav qis, kev phais mob ntau ntxiv, mob, mob hnyav cov teeb meem metabolic thiab endocrine, ntxiv rau electrolyte tsis txaus).
Hauv cov poj niam ntawm kev ua me nyuam hnub nyoog uas tsis siv kev tiv thaiv kom muaj txiaj ntsig, kev siv Liptonorm tsis pom zoo. Yog tias tus neeg mob tab tom npaj lub cev xeeb tub, nws yuav tsum tsum tsis txhob noj Liptonorm tsawg kawg ib hlis ua ntej ntawm kev npaj cev xeeb tub.
Tus neeg mob yuav tsum tau sab laj nrog kws kho mob tam sim ntawd yog tias tsis hnov qhov mob lossis cov leeg tsis muaj zog tshwm sim, tshwj xeeb tshaj yog tias lawv nrog mob npaws thiab kub taub hau.

Cawv rau ntawm kev muaj peev xwm tsav lub tsheb thiab ua haujlwm nrog cov tshuab

Qhov tshwm sim tsis zoo ntawm Liptonorm ntawm kev muaj peev xwm tsav lub tsheb thiab ua haujlwm nrog cov txheej txheem uas xav tau kev nce siab tsis tau qhia tawm.

Daim ntawv tso tawm

Coated ntsiav tshuaj ntawm 10 thiab 20 mg.
Hauv 7, 10 lossis 14 ntsiav tshuaj hauv Al / PVC cov hlwv.
1, 2, 3, 4 blisters nyob hauv pob ntawv cardboard ua ke nrog cov lus qhia rau kev siv.

Cia rau cov neeg mob

Sau B. Hauv qhov chaw qhuav thiab tsaus ntawm qhov kub thiab txias qis dua 25 ° C.
Khaws tsis ncav cuag ntawm cov menyuam yaus.

Hnub tas sij hawm

2 xyoos Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Cov Cai Siv Tshuaj So

Chaw tsim tshuaj paus:
"M.J. Biopharm", Is Nrias teb
113 Jolly Txiag Chambers-II, Nariman Point, Mumbai 400021, Is Nrias teb
Xov tooj: 91-22-202-0644 Fax: 91-22-204-8030 / 31

Sawv cev hauv Lavxias Lavxias
119334 Russia, Moscow, ul. Kosygina, 15 (GC Orlyonok), chaw haujlwm 830-832

Ntim:
Cov Kws Muag Tshuaj - Leksredstva OJSC
305022, Russia, Kursk, ul. Thib 2 Thib Ib, 1a / 18.
Tel / Fax: (07122) 6-14-65

Kev Sau ua ke, daim foos tso tawm

Lub zog tshuaj ntawm Liptonorm yog atorvastatinCov. Nws yog ntxiv nrog cov tshuaj pab: calcium carbonate, cellulose, mis qab zib, hydroxypropyl cellulose, croscarmellose, magnesium stearate, titanium dioxide, polyethylene glycol.

Liptonorm yog lub ntsej muag dawb, puag ncig, tawg pleb dawb. Muaj ob qho kev hloov pauv ntawm cov tshuaj nrog ib qho tshuaj ntawm cov ntsiab lus ntawm 10 lossis 20 mg.

Pharmacological kev txiav txim

Atorvastatin yog HMG-CoA reductase inhibitor. Qhov enzyme no yog qhov tsim nyog rau lub cev kom coj cov roj (cholesterol). Lub Liptonorm molecule yog qhov zoo sib xws hauv kev teeb tsa rau nws. Cov kab mob siab ua lub ntsej muag muab nws rau ib qho enzyme, suav nrog nyob rau hauv cov tshuaj tiv thaiv ntawm kev tsim cov roj cholesterol - nws tsum. Tom qab tag nrho, cov khoom ntawm atorvastatin tsis zoo ib yam li HMG-CoA reductase.

Cov theem roj siab poob qis dua. Txhawm rau kom them rau nws qhov tsis txaus, lub cev pib rhuav tshem cov molecules uas muaj LDL, uas ua rau txo qis hauv lawv cov kev xav. Ib qho txiaj ntsig ntxiv ntawm cov roj (cholesterol) yog cov ntaub so ntswg. Yuav kom thauj sterol, "zoo" high-density lipoproteins xav tau. Raws li, lawv tus lej nce zuj zus.

Txo cov roj (cholesterol) tag nrho, LDL, triglycerides ua rau kom cov ntshav atherosclerosis qeeb zuj zus. Txij li thaum tshaj cov khoom ntawm rog metabolism muaj peev xwm mus nthuav tawm nyob rau saum npoo ntawm cov hlab ntshav. Thaum qhov kev ua kom tiav los ua qhov tseem ceeb, nws ib feem lossis tag nrho npog lub lumen ntawm lub nkoj. Atherosclerosis ntawm lub plawv hlab ntog ua rau lub plawv nres, mob hlwb tawg, nqua - qhov tsim ntawm trophic mob rau sab hauv, ko taw necrosis.

Kev ua haujlwm ntawm atorvastatin raug txo qis rau xoom yog tias ib tus neeg tsis ua raws kev noj zaub mov uas xav txhawm rau txo cov roj (cholesterol). Lub cev tsis siv nws lub peev txheej los them rau cov tsis muaj menyuam yaus, vim nws los ntawm cov khoom noj.

Cov qib roj cholesterol pib lub cev tom qab 2 lub lis piam los ntawm kev pib noj tshuaj. Qhov siab tshaj plaws tau tiav tom qab 4 lub lis piam.

Atorvastatin metabolites raug tawm hauv lub bile, uas yog tsim tawm los ntawm daim siab. Nrog kev ua haujlwm hauv nruab nrog cev, txoj kev ua no yuav nyuaj. Yog li ntawd, nrog daim siab pathologies, cov tshuaj yog tshuaj kho kom zoo.

Liptonorm: kev taw qhia rau kev siv

Raws li cov lus qhia rau kev siv Liptonorm, cov tshuaj yog kws kho ntxiv rau kev noj zaub mov noj rau:

thawj hypercholesterolemia,
sib xyaw hyperlipidemia,
heterozygous thiab homozygous tsev neeg hypercholesterolemia yog ib qho ntxiv rau kev noj haus,

Kev siv cov atorvastatin pab txo txoj kev pheej hmoo mob stroke, mob plawv nres hauv cov neeg mob plawv. Tsis tas li ntawd, cov neeg mob noj Liptonorm tsawg dua yuav tsum tau shunting, stenting, pw hauv tsev kho mob nrog cov teeb meem plawv.

Txoj kev ntawm daim ntawv thov, ntau npaum li cas

Ua ntej pib kev kho mob nrog Liptonorm, ntxiv rau thoob plaws chav kawm, tus neeg mob yuav tsum ua raws kev noj haus.

Cov ntsiav tshuaj tau noj ib zaug / ib hnub, tsis muaj hais txog khoom noj, tab sis ib txwm tib lub sijhawm. Pom zoo kom pib koob tshuaj yog 10 mg. Ntxiv mus, cov koob tshuaj tau xaiv ib tus zuj zus, noj mus rau hauv tus account lub zog ntawm kev hloov hauv cov roj (cholesterol), LDL. Dosage kev kho kom haum yog nqa tawm tsis pub dhau 1 zaug / 4 lub lis piam. Qhov siab tshaj plaws tau pub rau noj yog 80 mg. Nrog kev tsis haum lub cev ntawm lub cev mus rau noj atorvastatin, tus neeg mob tau sau tshuaj noj muaj zog ntau dua statin lossis ntxiv nrog rau lwm cov tshuaj uas txo cov roj (cov roj ntsha kua qaub, cov roj (cholesterol) uas ua rau kom haum).

Nrog rau daim siab ua haujlwm, kev teem sijhawm Liptonorm yuav tsum tau nrog kev sojntsuam ntawm kev ua haujlwm ntawm lub cev. Yog tias lawv pom dhau qhov xwmtxheej dhau los, cov tshuaj raug muab tso tseg lossis qis dua kev kho mob.

Cov kev txuam nrog, phiv

Liptonorm yog contraindicated nyob rau hauv cov neeg uas nkag siab atorvastatin, lactose, ib qho twg ntawm cov tshuaj lossis analogue. Ntsiav tshuaj yog contraindicated nyob rau hauv:

mob kab mob siab
nce hauv ALT, GGT, AST los ntawm ntau dua 3 zaug,
mob hnyav
mob ntsws
cov me nyuam hnub nyoog qis dua 18 xyoo

Liptonorm tsis muaj cai rau cov niam kev cia siab, tus poj niam laus. Yog tias xeeb tub yog npaj los, cov tshuaj raug nres tsawg kawg ib hlis ua ntej hnub no. Nrog rau kev xeeb tub tsis tau tsim nyog, koj yuav tsum tsum tsis txhob noj tshuaj, thiab tom qab ntawd sab laj nrog kws kho mob. Nws yuav tham txog cov kev pheej hmoo txaus ntshai rau tus menyuam hauv plab, thiab tseem yuav qhia txog kev xaiv ua haujlwm.

Cov neeg mob feem ntau yooj yim zam cov tshuaj. Cov kev mob tshwm sim, yog tias muaj, mob me me, ploj tom qab lub sijhawm luv luv. Tab sis tej zaum ib tug tsis zoo optimistic ntawm kev tshwm sim.

Liptonorm cov lus qhia ceeb toom txog cov kev mob tshwm sim hauv qab no:

Lub cev tsis xis nyob: feem ntau pw tsis tsaug zog, kiv taub hau, tsis tshua muaj mob taub hau, mob siab, tsaug zog, npau suav phem, qaug zog, poob qis / nce siab, tsis nco qab, puas hlwb, chim siab, ua kom tsis muaj kev sib koom tes, ua kom lub ntsej muag tuag tes tuag taw, tsis nco qab.
Cov kabmob siab: ob lub zeem muag, pob ntseg lub ntsej muag, lub qhov muag qhuav, lag ntseg, lub ntsej muag daj, saj kev sib chwv.
Cov hlab plawv: feem ntau - mob hauv siab, tsis tshua muaj mob taub hau, mob plab, mob ntshav lossis mob ntshav siab, arrhythmia, angina pectoris, phlebitis.
Kab mob ntsws: feem ntau - mob ntsws, txhaws ntswg, tsis tshua mob - ntsws, ntsws, ntsws, ntsws.
Lub plab zom mov: xeev ntuav, kub siab, cem quav lossis mob raws plab, mob plab, roj, tsis nco qab lossis nce siab, lub qhov ncauj qhuav, duav, nqos lub plab, ntuav, mob plab, mob rau txoj hlab pas, tus nplaig, mob plab, mob siab, mob plab, mob plab duodenal , kab mob pancreatitis, mob daj ntseg, lub siab ua haujlwm tsis zoo, lub cev tawm ntawm lub qhov rooj, los ntshav ntawm cov pos hniav.
Musculoskeletal system: feem ntau - mob caj dab, tsis tshua muaj - mob caj pas mob, bursitis, mob sib koom tes, myositis, myopathy, myalgia, rhabdomyolysis, mob nqaij pob txha ntau zog.
Cov kab mob genitourinary: feem ntau - cov kab mob genitourinary, peripheral edema, tsis tshua muaj - dysuria, mob raum, mob ntshav tawm ntawm lub paum, mob ntawm qhov ntxiv ntawm cov noob qes, txo qis libido, impotence, cuam tshuam ntawm ejaculation.
Daim tawv nqaij: alopecia, nce tawm hws, eczema, plhaws, pom ntshav tawm.
Kev tsis haum tshuaj: khaus, tawm pob, hu rau dermatitis, urticaria, kev tiv thaiv tsis haum, ua kom lub cev yuag, anaphylaxis.
Kev ntsuas qhov ntsuas: muaj siab / tsis muaj piam thaj, muaj zog ntau dua CPK, alkaline phosphatase, ALT, AST, GGT, ntshav tshuaj, ntshav thom khwm, thrombocytopenia.
Lwm yam: ua kom yuag, gynecomastia, exacerbation ntawm gout.

Feem ntau feem ntau, haus luam yeeb, haus dej cawv, cov neeg mob ntshav qab zib, lub qog tsis txaus, mob siab, hypotension raug kev phiv.

Ncua Liptonorm, thiab tseem hu rau koj tus kws kho mob yog tias:

cov leeg mob tsis muaj zog lossis tsis muaj zog,
kub nce
cramps.

Kev sib txuam

Cov tshuaj yuav tuaj yeem ua nrog cov tshuaj hauv qab no:

tshuaj tua kab mob (omeprazole, almagel),
digoxin
erythromycin, clarithromycin,
protease inhibitors
qee qhov ncauj tsis pub muaj me nyuam
fibrates
warfarin
itraconazole, ketoconazole.

Cov tshuaj tsis raug muag los ntawm cov khw muag tshuaj hauv Lavxias. Nws tau tas sijhawm rau daim ntawv pov thawj rau npe. Tus nqi ntawm Liptonorm thaum lub sijhawm ploj ntawm kev muag khoom yog 284 rubles rau 10 mg pob, 459 rubles rau 20 mg.

Qhov tsis muaj Liptonorm cov chaw muag tshuaj tsis yog teeb meem. Muaj ntau ntau cov yeeb yam tawm ntawm cov tshuaj nrog tib cov tshuaj nquag. Koj tuaj yeem nug hauv cov khw muag tshuaj:

Atoris
Tus tub sab
Cov Atomax
Cov Ator
Tulip
Atorvastitin-OBL,
Atorvastatin-Teva,
Atorvastatin MS,
Atorvastatin Avexima,
Atorvox
Vazator
Lipoford
Liprimar
Novostat,
Keebkwm
Torvalip
Thorvacard
Torvazin.

Ntxiv rau cov tshuaj saum toj no, koj tuaj yeem nqa Liptonorm analogues los ntawm kev ua haujlwm ntawm cov haujlwm:

simvastatin - 144-346 rubles.,
lovastatin - 233-475 rubles.,
rosuvastatin - 324-913 rub.,
fluvastatin - 2100-3221 rub.

Txhua statins muaj tib lub tshuab ntawm kev txiav txim, tab sis txhua ntawm lawv muaj nuances ntawm kev siv. Yog li, ib txwm nrog koj tus kws kho mob tham ua ntej hloov cov tshuaj.

Cov ntaub ntawv npaj los ntawm tus sau phau ntawv ntawm qhov project
raws li txoj cai kho ntaub ntawv ntawm lub xaib.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Liptonorm muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj: coated nrog lub plhaub dawb, puag ncig, biconvex, thaum lub sijhawm so - dawb lossis yuav luag dawb (14 pcs. Hauv cov hlwv, 2 lub hlwv hauv ib pob ntawv cardboard).

Cov tshuaj nquag siv ntawm cov tshuaj yog atorvastatin (nyob rau hauv daim ntawv ntawm calcium calcium). Hauv 1 lub tshuaj nws muaj 10 lossis 20 mg.

Cov neeg mob: crosscarmelose, hydroxypropyl cellulose, magnesium stearate, kaum yim 80, lactose, hydroxypropyl methyl cellulose, microcrystalline cellulose, titanium dioxide, calcium carbonate, polyethylene glycol.

Muaj pes tsawg leeg thiab noj ntau npaum

Lub hauv paus tseem ceeb ntawm Liptonorm yog Atorvastatin calcium trihydrate rau hauv daim ntawv ntawm calcium ntsev. Ntawm nws cov ntu muaj xws li:

calcium carbonate
Ntxaib 80,
MCC
cov khoom noj khoom haus ntxiv E463 thiab E572,
croscarmellose sodium,
lactose
lim dej.

Liptonorm yog ua hauv ntsiav tshuaj daim ntawv. Coated ntsiav tshuaj ntawm 10 mg lossis 20 mg yog muaj nyob hauv qhov ntau ntawm 7, 10, 14, 20, 28 lossis 30 pcs.

Kev ntsuas rau siv

Cov tshuaj yog tawm rau kev nce roj. Nws qhov kev ua yog tsom rau inhibiting lipid cov ntsiab lus hauv cov ntshav. Liptonorm yuav tsum tau siv hauv qhov ntau npaum li cas los ntawm tus kws kho mob.

Cov tshuaj Liptonorm muaj qhov kev pom ntawm qhov dav dav. Cov tshuaj muaj lipid-txo qis thiab tiv thaiv atherosclerotic. Cov lipid-txo cov nyhuv ntawm cov tshuaj Liptonorm yog tias nws cov tshuaj nquag ua rau muaj kev tiv thaiv cov roj (cholesterol) thiab tshem cov ntshav ntawm LDL los ntawm cov ntshav ntshav.

Cov tshuaj los tiv thaiv atherosclerotic yog ua raws li qhov tseeb tias tshuaj muaj peev xwm txhawb kev loj hlob ntawm cov hlwb hauv cov hlab ntsha thiab txo cov ntsiab lus ntawm cov ntshav lipid. Vim tias qhov dav dav ntawm kev nqis tes ua, cov tshuaj yuav tsum tau tsim tawm rau cov kab mob hauv qab no:

kev tshuaj ntsuam genetic predisposition rau cov lipid ntau heev ntxiv,
dyslipidemia,
hetero - los yog homozygous daim ntawv ntawm tsev neeg hom hypercholesterolemia.

Liptonorm yuav tsum tsis txhob tso siab rau qhov tshuaj rau qhov hnyav cev Liponorm. Ntxiv nrog rau qhov tseeb tias tom kawg yog kev noj haus ntxiv, nws tsuas yog muag hauv tsiav tshuaj.

Sab sij huam

Yog hais tias tus neeg mob txhob txwm tsis quav ntsej contraindications los yog ntau tshaj li qhov muab tshuaj ntawm cov ntsiav tshuaj, nws yuav muaj kev cuam tshuam los ntawm kev pheej hmoo ntawm kev phiv. Kev tsis ua raws li cov cai ntawm kev kho tej zaum yuav ua rau muaj yeej tshuab hauv qab thiab kabmob:

CNS Lub ntsiab tseem ceeb ntawm kev ua haujlwm tsis zoo ntawm lub paj hlwb yog kiv taub hau thiab pw tsaug zog. Hauv cov xwm txheej cais, cov neeg mob ntsib cov tsos mob xws li npau suav phem, asthenia, ataxia, paresis thiab hyperesthesia, uas ua rau muaj kev nyuaj siab ntev.
Hnov kabmob. Cov cim ntawm kev ua txhaum ntawm lawv cov kev ua haujlwm tau suav hais tias yog kev mob ntshav hauv lub qhov muag, tsis muaj qhov muag tiv thaiv kev ya raws, tsis muaj qhov hnov txhua yam thaum noj mov, tsis muaj peev xwm los ntes tus ntxhiab
Lub kaw lus genitourinary. Mob raum thiab lub paum, teeb meem tso zis, kev txhim kho ntawm lub raum tsis ua haujlwm thaum kho, txo qis potency yog cov kev mob tshwm sim ntau tshaj plaws thaum kho Liptonorm.
Lymphatic systemCov. Cov txheej txheem kho mob ntawm txoj kev kho mob tuaj yeem ua rau mob ntshav ntshav tiv thaiv kab mob - lymphadenopathy, ntshav liab lossis thrombocytopenia.
Lub plab zom mov. Kev tsis ua raws li cov kev cai ntau npaum li cas ntawm cov ntsiav tshuaj raws li cov lus qhia ua rau muaj kev txhim kho ntawm cov kab mob ntawm lub plab zom mov thiab mob siab, uas tau tshwm sim los ntawm tsam plab, rumbling, ntuav reflex, daim siab mob plab, thiab txawm tias mob siab.
Kev kho plawv. Cov neeg mob yuav tuaj yeem pom txoj kev ntshav ntawm txoj hlab ntshav liab, mob hlab ntaws lub ntsws, mob hauv siab.
Kev sib sau ua ke. Cov tshuaj tiv thaiv kab mob ua xua lossis ua xua xws li ua pob, khaus, ua paug, mob daj ntseg, tsis tshua mob urticaria lossis mob anaphylactic.

Cov lus qhia rau kev siv

Liptonorm yog tus sawv cev ntawm pawg tshuaj tau siv hauv kev kho ntau dhau ntawm cov lipid tshuav nyiaj li cas. Atorvastatin - qhov ua haujlwm tseem ceeb, muaj cov roj lipid-txo cov nyhuv, uas yog, nws pab txo qis lipid cov ntshav hauv cov ntshav. Nws cov ntsiab lus hauv cov ntshav siab tom qab kwv yees li 1 teev tom qab thov. Thaum sawv ntxov, daim duab no kwv yees li 30% siab dua yav tsaus ntuj.

Qhov tshwm sim los ntawm kev siv statins yog pom tom qab 14 hnub. Qhov siab tshaj plaws tau tiav tsuas yog tom qab 1 lub hlis ntawm kev siv.

Kev noj tshuaj tsis yog nyob ntawm kev noj zaub mov hauv lub cev. Tib qho xwm txheej uas ua rau muaj txiaj ntsig zoo ntawm kev siv tshuaj yog qhov noj tshuaj txhua hnub ntawm tib lub sijhawm. Tus neeg mob yuav tsum tsis pub tshaj qhov tshaj tawm - 10 mg ib hnub twg. Tshaj cov kev noj tshuaj txhua hnub tuaj yeem ua rau muaj kev phom sij loj rau kev noj qab haus huv thiab ua rau cov kev tsis haum siab xav tau.

Ua ntej pib txoj kev kho mob, cov kws kho mob yuav tsum saib xyuas lub siab ua haujlwm. Cov kws tshaj lij pom zoo kom ceeb toom thiab nquag mus ntsib kws kho mob los saib xyuas lub siab ua haujlwm hauv thawj 3 lub hlis tom qab pib kho. Kev hloov koob tshuaj tuaj yeem nqa tawm ntau lub lis piam tom qab pib kho mob, tab sis tsis ntau tshaj 1 zaug hauv ib hlis. Thaum lub sijhawm nws nkag, cov kws kho mob yuav tsum nyob txhua 6 lub hlis. tswj cov kev hloov hauv enzyme tshuav nyiaj li cas.

Raws li cov xwm txheej ntawm kev siv, cov ntsiav tshuaj yuav tsum muab cia rau hauv qhov chaw txias. Kev pom zoo ntsuas kub hauv chav no +25 degrees.

Siv thaum cev xeeb tub

Cov yeeb tshuaj tseem ceeb yog txwv rau cov neeg mob thaum cev xeeb tub thiab thaum cev xeeb tub (pub niam mis) vim muaj qhov tsis zoo rau lub cev ntawm tus menyuam yug tshiab. Yog hais tias tus neeg mob tau npaj lub cev xeeb tub, nws zoo dua los tso nws rau ob peb lub hlis. Cov poj niam thaum kho mob Liptonorm yuav tsum tsis txhob saib tsis taus me nyuam.

Lwm txoj kev siv sib txuam nrog rau thaum yau thiab thaum tiav hluas. Cov ntaub ntawv hais txog kev kho mob ntawm cov menyuam yaus nrog rau cov tshuaj rau tam sim no tsis muaj.

Tus nqi tshuaj

Tus nqi ntawm cov tshuaj Liptonorm yog txiav txim siab los ntawm ntau cov qauv - tus naj npawb ntawm cov hlwv hauv pob, ntau npaum li cas, thiab lwm yam. Qhov nruab nrab, 10 ntsiav tshuaj mg tuaj yeem yuav hauv chaw muag tshuaj rau 200-250 rubles. Tus nqi ntawm ib pob ntawm 28 pcs. 20 mg txhua yog 400-500 rubles.

Hauv Ukraine, tus nqi ntawm ib cov tshuaj hauv qhov ntau npaum ntawm 20 mg yog 250-400 UAH.

Cov Lus Cim Liptonorm

Txawm hais tias Liptonorm yog ib hom tshuaj uas ua tau zoo heev, nws yuav tsis haum rau txhua tus neeg mob. Hypersensitivity rau ib qho kev sib xyaw ntawm cov tshuaj thiab overpriced yog ob qho laj thawj rau kev hloov nws nrog cov roj hmab pheej yig dua.

Cov tshuaj hauv qab no yog nyob ntawm cov analogues ntawm Liptonorm:

Kev Siv Tshuaj Xyuas

Kev tshuaj xyuas ntawm nws txoj kev siv qhia tau hais tias cov kws kho mob feem ntau muab tshuaj rau tus neeg mob yam tsis muaj cov ntsiab lus piav qhia txog cov yam ntxwv ntawm nws txoj kev tswj hwm thiab cov kev mob tshwm sim.

Tamara, Moscow: “Thawj thawj hnub tom qab kuv noj tshuaj, Kuv pib mob plab, tom qab ntawd tso hauv plab, thiab ob peb hnub tom qab, xeev siab thiab ntuav. Kuv tsis nyob rau hauv txhua txoj kev koom cov kev qhia nrog Liptonorm. Txij li thaum kuv tau raug kev txom nyem los ntawm kev mob ntawm txoj hnyuv txij li thaum yau nrog kev hloov me me hauv kuv cov zaub mov, Kuv tam sim tig mus rau tus kws kho mob plab. Ua tsaug rau tus kws kho mob, Kuv pom tau hais tias dab tsi ua rau muaj kev tsis xis nyob hauv plab, tab sis kuv tseem mob siab txog cov lus nug. Vim li cas kuv cov neeg noj zaub mov tsis ceeb toom kuv txog qhov yuav tshwm sim? ”

Catherine, Novosibirsk: "Kuv lub cev hnyav dhau los nrog kuv txij thaum kuv tus tub ntxhais hluas lub xyoo, tab sis tsuas yog thaum muaj hnub nyoog 30 xyoo kuv txiav txim siab saib xyuas kuv tus kheej thiab pom qhov ua rau kuv qhov teeb meem. Kev tshawb nrhiav pom tau hais tias qhov ua rau yog cov muaj roj (cholesterol) thiab cov kws qhia noj zaub mov noj Liptonorm rau kuv.Thawj hnub, kuv cov ntshav siab tau nce mus txog 150. Hnub tom qab thaum sawv ntxov lub siab yog qhov qub, tab sis tom qab noj su nws dhia ntxiv rau 160. Tom qab ntawd, kuv txiav txim siab rov nyeem cov lus qhia thiab thaum kawg kuv nkag siab tias muaj xwm txheej dab tsi. Kuv cov ntshav siab yog qhov tshwm sim ntawm cov tshuaj. Lub siab nres cia li nce tsuas yog 5 hnub tom qab pib kev kho mob. "

Kev nthuav qhia tag nrho cov kev txheeb xyuas saum toj no txog kev siv Liptonorm ntsiav tshuaj, nws yuav tsum txiav txim siab tias nws yog qhov yuav tsum tau sab laj tus kws kho mob ua ntej siv. Firstly, qhov no yog vim qhov tseeb hais tias cov tshuaj muaj npe rau cov pab pawg ntawm cov statins uas tuaj yeem tiv thaiv qhov nce hauv cov cholesterol. Raws li koj paub, kev teem sijhawm lossis tshem tawm qee tus neeg sawv cev cev xeeb tub tsuas tuaj yeem nqa los ntawm tus kws tshaj lij xwb.

Thib ob, cov tshuaj muaj ntau yam kev tiv thaiv thiab kev phiv los ntawm txoj hnyuv hauv plab, lub hauv plab mob hlwb, lub plawv thiab lwm cov kab ke tseem ceeb. Tus kws kho mob tshwj xeeb yuav tsum sau daim ntawv tshuaj noj, piav qhia txhua yam hauv daim ntawv thov, thiab qhia tus neeg mob txog kev muaj teeb meem.

Tsuas tshuaj thiab tswj hwm

Ua ntej sau ntawv tawm Liptonorm thiab tag nrho lub sijhawm ntawm nws siv, tus neeg mob yuav tsum ua raws li cov khoom noj uas muab cov ntshav lipids txo qis.

Cov tshuaj tau noj ntawm qhov ncauj 1 zaug hauv ib hnub, tsis hais txog noj mov, tib lub sijhawm.

Qhov hno tshuaj txhua hnub feem ntau yog 10 mg. Tom ntej no, cov koob tshuaj tau raug hloov kho ib tus zuj zus, raws li cov ntsiab lus roj (cholesterol) ntawm cov roj lipoproteins tsawg. Lub sijhawm nruab nrab ntawm cov hloov pauv yuav tsum tsis pub tsawg tshaj 4 lub lis piam. Qhov siab tshaj plaws tau tso cai rau noj txhua hnub yog 80 mg.

Sab sij huam

Muaj cov mob tshwm sim los ntawm cov tshuaj (feem ntau - ntau dua 2%, tsis tshua - tsawg dua 2%):

Nruab nrab hauv lub paj hlwb: feem ntau - kiv taub hau, pw tsaug zog, tsis tshua muaj - malaise, asthenic syndrome, nkees nkees, mob taub hau, npau suav phem, lub siab lub zog, lub hlwb tsis nco qab, ataxia, paresthesia, ntsej muag txhawm, hyperesthesia, hyperkinesia, amnesia, kev nyuaj siab, ploj ntawm nco qab
Kev mob plawv: feem ntau mob hauv siab, tsis tshua mob postural hypotension, arrhythmia, vasodilation, nce lub plawv dhia, angina pectoris, nce ntshav siab, phlebitis,
Cov kabmob hauv lub cev: qhuav qog ua paug, mob ntsej muag, mob ntshav hauv lub qhov muag, tsis txaus ntseeg, cuam tshuam ntawm kev pab, parosmia, nrov hauv lub pob ntseg, lag ntseg, perversion ntawm saj, tsis hnov tsw,
Kab mob ntsws: feem ntau - rhinitis, mob ntsws, tsis tshua muaj - txhawm ntswg, mob ntsws, mob ntsws, ntsws asthma, dyspnea,
Lub plab zom mov: feem ntau - cheilitis, los ntawm cov pos hniav los ntshav, ua paug thiab mob tawm ntawm lub qhov ncauj ntawm qhov ncauj, stomatitis, glossitis, lub qhov ncauj qhuav, tenesmus, cem quav lossis mob raws plab, kub siab, mob plab, xeev siab, mob plab, ntuav, mob plab, ntuav, dysphagia , esophagitis, mob ntshav qab zib lossis ntau yam qab los, mob plab hnyuv duodenal, kab mob siab rau lub plab, mob plab, mob siab, ua rau lub siab ua haujlwm tsis txaus siab, cholestatic jaundice, pancreatitis, melena, los ntshav tawm,
Cov kab mob genitourinary: feem ntau - peripheral edema, mob urogenital, tsis tshua muaj - hematuria, nephritis, nephrourolithiasis, dysuria (suav nrog kev tso zis tsis ua haujlwm lossis tso zis cia, nocturia, pollakiuria, tso zis tseev kom), metrorrhagia, ntshav tawm ntawm qhov paum, mob epididymitis, ejaculation, tsawg libido, impotence,
Musculoskeletal system: feem ntau - mob caj dab, tsis tshua muaj - tendosynovitis, bursitis, myositis, mob myalgia, arthralgia, torticollis, mob hauv pob txha, txha sib cog lus, mob hypertonicity, myopathy, rhabdomyolysis,
Hematopoietic system: lymphadenopathy, ua haujlwm tsis txaus, thrombocytopenia,
Dermatological thiab kev ua xua: tsis tshua muaj - nce tawm hws, seborrhea, xeroderma, eczema, petechiae, ecchymosis, alopecia, khaus, tawv nqaij ua pob, hu rau dermatitis, tsis tshua muaj - ua ntsej muag, mob raum, mob ua paug, ua kom zoo nkauj, muaj ntau yam mob uas tsis muaj kuab lom erythema. Stevens-Johnson mob ntsws, anaphylaxis,
Qhov ntsuas qhov ntsuas: tsis tshua muaj - albuminuria, hypoglycemia, hyperglycemia, kev ua si ntau ntawm alkaline phosphatase, ntshiab si creatinine phosphokinase thiab hepatic transaminases,
Lwm yam: tsis tshua muaj - mastodynia, gynecomastia, qhov hnyav nce, exacerbation ntawm gout.

Cov lus qhia tshwj xeeb

Thoob plaws txhua lub sijhawm ntawm kev kho mob, yuav tsum ua tib zoo saib kev kuaj mob thiab kuaj ntsuas ntawm lub cev ua haujlwm yog qhov tsim nyog. Yog tias pom qhov tseem ceeb ntawm cov kab mob hloov pauv hloov, qhov kev txhaj tshuaj ntawm Liptonorm yuav tsum tau txo lossis nws txoj kev noj mov nres tag nrho.

Ua ntej sau cov tshuaj, tom qab ntawd 6 thiab 12 lub lis piam tom qab pib kho, tom qab txhua tus koob tshuaj nce ntxiv, raws li lub sijhawm txuas ntxiv hauv kev kho mob (piv txwv, txhua 6 lub hlis), lub siab ua haujlwm yuav tsum tau saib xyuas. Ib qho kev hloov pauv ntawm cov enzyme feem ntau pom nyob hauv thawj 3 lub hlis ntawm kev noj Liptonorm. Nyob rau hauv cov ntaub ntawv ntawm kev ua si ntau ntawm hepatic transaminases, cov neeg mob yuav tsum tau nyob ze kev saib xyuas kev kho mob kom txog thaum ntsuas rov qab. Yog tias tus nqi ntawm alanine aminotransferase (ALT) lossis tshuaj aspartate aminotransferase (AST) yog ntau dua 3 zaug ntau dua li tus nqi rau kev ua haujlwm ntawm adrenal hyperplasia, nws raug nquahu kom txo cov koob tshuaj lossis rho tawm cov tshuaj.

Nws yog qhov tsim nyog los sib piv cov txiaj ntsig uas xav tau thiab qib kev pheej hmoo yog tias nws yuav tsum tau tswj Liptonorm rau tus neeg mob uas tau txais cyclosporine, erythromycin, clarithromycin, immunosuppressants, fibroic acid derivatives, nicotinic acid (hauv cov tshuaj uas muaj lipid-txo cov nyhuv), cov tshuaj tua kab mob uas yog azole derivatives. Yog tias muaj cov cim ntawm cov leeg mob, tsis muaj zog lossis qaug zog, tshwj xeeb tshaj yog thawj ob peb lub hlis ntawm kev kho lossis nrog qhov nce ntxiv ntawm ib qho tshuaj twg, cov neeg mob yuav tsum tau ua tib zoo saib xyuas.

Yog tias muaj kev pheej hmoo txaus rau kev txhim kho ntawm lub raum tsis ua haujlwm vim qhov mob rhabdomyolysis (piv txwv li, mob ntshav nce hlwb, mob ntshav qabzib thiab endocrine tsis zoo, mob hnyav, mob, kev phais mob ntau ntxiv, hluav taws xob tsis txaus), ntxiv rau thaum mob hnyav uas yuav qhia tau kev txhim kho ntawm myopathy, Liptonorm yuav tsum yog ib ntus los sis tag nrho tshem tawm.

Tus neeg mob yuav tsum tau txais kev ceeb toom txog qhov yuav tsum tau sab laj nrog tus kws kho mob tam sim ntawd yog tias koj tau hnov mob tsis muaj zog lossis cov leeg tsis hnov mob, thiab tshwj xeeb yog tias lawv nrog los ntawm malaise thiab / lossis kub cev.

Tsis muaj xov xwm qhia txog kev cuam tshuam tsis zoo ntawm Liptonorm ntawm kev muaj peev xwm tsav tsheb thiab ua haujlwm uas xav tau kev saib xyuas.

Yeeb tshuaj sib cuam tshuam

Immunosuppressants, antifungal cov neeg sawv cev muab tau los ntawm azole, fibrates, cyclosporine, erythromycin, clarithromycin, nicotinamide nce qhov siab ntawm atorvastatin hauv cov ntshav ntshav thiab qhov pheej hmoo ntawm kev tsim myopathy.

Qib theem ntawm cov tshuaj nquag ntawm Liptonorm kuj tau nce los ntawm CYP3A4 inhibitors.

Antacids txo cov tshuaj atorvastatin los ntawm 35%, tab sis tsis cuam tshuam rau cov roj cholesterol ntawm lipoproteins tsawg ntom.

Thaum noj Liptonorm hauv ib hnub 80 mg ib txhij nrog digoxin, qhov kev txiav txim ntawm tom kawg hauv cov ntshav nce txog li 20%.

Liptonorm, noj nyob rau hauv ib koob ntawm 80 mg txhua hnub, nce qhov kev txiav txim siab ntawm qhov ncauj txwv tsis pub muaj ethinyl estradiol lossis norethidrone los ntawm 20%.

Cov nyhuv hypolipidemic ntawm kev sib xyaw ntawm atorvastatin nrog colestipol yog qhov zoo dua rau cov kev cuam tshuam hauv txhua qhov tshuaj ib leeg zuj zus.

Nyob rau hauv cov ntaub ntawv ntawm kev siv tib lub sij hawm ntawm warfarin hauv thawj hnub ntawm kev kho mob, lub sijhawm prothrombin poob qis, tab sis tom qab 15 hnub no ntsuas, raws li txoj cai, normalizes. Vim li no, cov neeg mob tau txais kev sib koom ua ke yuav tsum tswj hwm lub sijhawm prothrombin ntau dua li ib txwm muaj.

Thaum kho, nws tsis pom zoo kom haus cov kua txiv kab ntxwv qaub, vim nws tuaj yeem pab txhawb ntxiv ntawm atorvastatin hauv cov ntshav ntshav.