Amoksiklav - (Amoksiklav -) cov lus qhia rau siv > Kev khomob thiab kev tiv thaiv

Hmoov rau qhov kev npaj tawm ntawm lub ncua kev kawm ntawv rau qhov ncauj tswj hwm los ntawm dawb mus rau daj-dawb, qhov raug tshem tawm npaj yog homogeneous, los ntawm yuav luag dawb mus rau daj.

5 ml ntawm kev tshem tawm tiav.
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	125 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	31,25 mg

Tshwjxeeb: anhydrous citric acid, anhydrous sodium citrate, sodium benzoate, microcrystalline cellulose, sodium carmellose, xanthan ntawm cov pos hniav, colloidal silicon dioxide, silicon dioxide, sodium saccharinate, mannitol, flavings (strawberry, cherry qus, txiv qaub).

25 g - fwj ntawm cov iav dub uas ntim nrog 100 ml (1) ua tiav nrog ib rab diav tshuaj / lub raj dej - cov ntim cov duab los qhia.

Hmoov rau qhov kev npaj tawm ntawm lub ncua kev kawm ntawv rau qhov ncauj tswj hwm los ntawm dawb mus rau daj-dawb, qhov raug tshem tawm npaj yog homogeneous, los ntawm yuav luag dawb mus rau daj.

5 ml ntawm kev tshem tawm tiav.
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	250 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	62,5 mg

25 g - fwj ntawm cov iav dub uas ntim nrog 100 ml (1) ua tiav nrog ib rab diav tshuaj / lub raj dej - cov ntim cov duab los qhia.

Hmoov rau qhov kev npaj tawm ntawm lub ncua kev kawm ntawv rau qhov ncauj tswj hwm los ntawm dawb mus rau daj-dawb, qhov raug tshem tawm npaj yog homogeneous, los ntawm yuav luag dawb mus rau daj.

5 ml ntawm kev tshem tawm tiav.
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	400 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	57 mg

Tshwjxeeb: anhydrous citric acid, anhydrous sodium citrate, microcrystalline cellulose, carmellose sodium, xanthan ntawm cov pos hniav, colloidal silicon dioxide, silicon dioxide, sodium saccharin, mannitol, flavings (strawberry, cherry qus, txiv qaub).

8.75 g - 35 ml tsaus iav fwj (1) ua tiav nrog lub raj tshuaj dosing - pob ntawv los qhia.
12,5 g - lub khob ntawm cov iav dub uas ntim nrog 50 ml (1) ua tiav nrog lub raj tshuaj dosing - pob khoom ntawm cardboard.
17,5 g - tsaus iav fwj uas ntim ntawm 70 ml (1) ua tiav nrog lub raj tshuaj dosing - pob ntawv los qhia.
35 g - 140 ml tsaus iav lub raj mis (1) ua tiav nrog lub dosing pipette - cov duab los qhia.

Pharmacological kev txiav txim

Amoxiclav ® yog kev sib xyaw ua ke ntawm amoxicillin - semisynthetic penicillin nrog ntau yam kev ua haujlwm tiv thaiv kab mob thiab clavulanic acid - qhov tsis paub kev tiv thaiv ntawm β-lactamases. Clavulanic acid ua rau lub zog ua haujlwm ruaj khov nrog cov enzymes thiab ua kom cov tsis kam ntawm amoxicillin rau kev cuam tshuam ntawm β-lactamases ua los ntawm cov kab mob me me.

Clavulanic acid, zoo sib xws hauv cov qauv tsim cov tshuaj tua kab mob beta-lactam, muaj qhov ua haujlwm tsis muaj zog tiv thaiv kab mob tua kab mob.

Amoxiclav ® muaj qhov kev pom ntawm kev siv tshuaj tua kabmob.

Nws ua rau cov kab mob tsis haum rau amoxicillin, suav nrog cov kab mob tawm producing-lactamases, incl. Cov kab mob aerobic kab mob Gram-positive: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (tshwj tsis yog kab mob methicillin-tiv thaiv kab mob), Staphylococcus epidermidis (tshwj tsis yog methicillin-tiv thaiv kab mob, tus kab mob spococcus, tus kab mob spococcus, Stroccococcus, Stroccococcus) : Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp., Moraxella catarrhalis spp., Neisseria gonorrhoeae spp. , Vibrio cholerae, Yersinia enterocolitica, Helicobacter pylori, Eikenella corrodens, anaerobic gram-cov kab mob zoo: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., Gram-negative anaerobes: Bacteroides spp.

Cov Tshuaj Pharmacokinetics

Lub ntsiab pharmacokinetic tseem ceeb ntawm amoxicillin thiab clavulanic acid yog qhov zoo sib xws.

Ob qhov sib xyaw ua ke tau zoo tom qab noj cov tshuaj hauv, noj mov tsis cuam tshuam rau qib ntawm kev nqus. C max hauv ntshav ntshav tau tiav 1 h tom qab kev coj noj coj ua. Qhov tseem ceeb ntawm C max rau amoxicillin (nyob ntawm lub koob tshuaj) yog 3-12 μg / ml, rau clavulanic acid - txog 2 μg / ml.

Ob qhov sib xyaw ua ke los ntawm cov ntim zoo hauv kev faib tawm hauv lub cev thiab cov nqaij (lub ntsws, nruab nrab pob ntseg, dej pleural thiab peritoneal, lub tsev me nyuam, zes qe menyuam, thiab lwm yam). Amoxicillin tseem nkag mus rau hauv cov kua ntshav synovial, mob siab, lub caj pas prostate, palatine tonsils, cov leeg nqaij, lub zais zis, lub zais ntawm cov ntshav, cov qaub ncaug, lub ntsej muag zais zis.

Amoxicillin thiab clavulanic acid tsis nkag rau BBB nrog uninflamed meninges.

Amoxicillin thiab clavulanic acid hla lub plab placental thiab nyob rau hauv cov nyiaj taug lw yog tawm hauv niam cov kua mis. Amoxicillin thiab clavulanic acid yog qhov cim los ntawm kev khi qis rau cov ntshav protein.

Amoxicillin yog qee cov metabolized, clavulanic acid yog pom meej tias muaj cov metabolism hauv lub zog.

Amoxicillin ua tawm los ntawm lub raum yuav luag tsis hloov pauv los ntawm tubular tso pa thiab glomerular pom. Clavulanic acid yog tawm los ntawm glomerular pom, ib feem nyob rau hauv daim ntawv ntawm metabolites. Cov zaub mov me me tuaj yeem tawm ntawm txoj hnyuv thiab lub ntsws. T 1/2 ntawm amoxicillin thiab clavulanic acid yog 1-1.5 teev.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Hauv kev mob tsis zoo rau lub raum, T 1/2 nce rau 7.5 teev rau amoxicillin thiab nce txog 4,5 teev rau clavulanic acid. Ob qho kev sib xyaw ua ke raug tshem tawm los ntawm hemodialysis thiab tus nqi me me los ntawm peritoneal lim ntshav.

Qhia Txog Amoxiclav ®

Cov kab mob kis tau los ntawm cov kab mob raug taus ntawm cov kab mob me me:

kis kab mob ntawm cov pa hauv siab thiab cov kabmob ENT (suav nrog rau mob siab thiab ntev, mob siab thiab ntev oitis media, pharyngeal abscess, tonsillitis, pharyngitis),
kis kab mob ntawm cov pa hauv qis (nrog rau kev mob ntsws zoo nrog cov kab mob superinfection, mob ntsws txhaws ntev, mob ntsws),
mob txeeb zig
cov kab mob gynecological
kis tau ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau tsiaj thiab tib neeg tom,
pob txha thiab mob pob txha mos,
biliary huam mob (cholecystitis, cholangitis),
odontogenic tau tus kab mob.

ICD-10 cov lis dej num

ICD-10 code	Kev taw qhia
H66	Purulent thiab tsis tau hais tawm otitis media
J00	Mob taub hau mob ntsws (los ntswg)
J01	Mob sinusitis
J02	Mob pharyngitis
J03	Mob tonsillitis
J04	Mob laryngitis thiab mob tracheitis
J15	Cov kab mob ntsws mob ntsws, tsis nyob rau lwm qhov
J20	Mob ntsws hawb pob
J31	Mob ntsws hnoos qeev, nasopharyngitis thiab mob pharyngitis
J32	Mob ntsws pob txha ntev
J35.0	Mob ua ntev tonsillitis
J37	Mob ntsws muaj mob thiab mob rau sab hauv lub ntsws
J42	Mob ntsws ntev ntev, tsis pom tseeb
K05	Mob pos hniav thiab ncig raws ncig
K12	Stomatitis thiab mob txhab ntxiv
K81.0	Mob cholecystitis
K81.1	Mob txha caj dab ntev
K83.0	Cholangitis
L01	Ncauj Tsis Hnov
L02	Daim tawv ua qog, rwj thiab carbuncle
L03	Phlegmon
L08.0	Pauj Kev Ntsim Siab
M00	Pyogenic mob caj dab
M86	Osteomyelitis
N10	Mob leeg taub-interstitial nephritis (mob pyelonephritis mob)
N11	Mob leeg txoj hlab ntsws ntev (nephritis)
N30	Cystitis
N34	Kev mob caj pas thiab txoj hlab zis
N41	Cov mob o ntawm lub prostate
N70	Kev mob salpingitis thiab oophoritis
N71	Tus mob o, tshwj tsis yog rau lub ncauj tsev menyuam (suav nrog endometritis, myometritis, metritis, pyometra, uterine abscess)
N72	Kab mob o (xws li mob ncauj tsev menyuam, endocervicitis, exocervicitis)
T14.0	Kev raug mob ntawm thaj chaw uas tsis pom tseeb hauv lub cev (suav nrog kev ua kom puas, doog, doog, hematoma, tom ntawm cov kab uas tsis muaj tshuaj lom)

Kev noj tshuaj ntxiv

Kev muab qhov kev ncua txhua hnub 125 mg + 31.25 mg / 5 ml thiab 250 mg + 62.5 mg / 5 ml (los pab txhawb cov tshuaj kom raug ncua kev tsim nyog, txhua pob koob muaj 125 mg + 31.25 mg / 5 ml thiab 250 mg + 62.5 mg / 5 ml nrog lub peev xwm ntawm 5 ml lossis kawm tiav pipette).

Cov menyuam mos thiab menyuam hnub nyoog txog 3 hlis muaj hnub nyoog 30 mg / kg (rau amoxicillin) / hnub, muab faib ua 2 koob (txhua 12 teev), rau cov menyuam yaus hnub nyoog tshaj 3 hlis - los ntawm 20 mg (rau amoxicillin) / kg / hnub rau kev kis mob me thiab mob nruab nrab mob hnyav txog 40 mg / kg (raws li amoxicillin) / hnub rau mob hnyav thiab mob ntsws, tau faib ua 3 koob (txhua 8 teev).

Cov koob tshuaj pom zoo kom tsis pub ncua kev kawm ntawv nce nyob ntawm lub cev qhov hnyav ntawm tus menyuam thiab qhov kis mob hnyav.

Lub cev hnyav (kg)	Hnub nyoog (kwv yees)	Lub ntsws / mob hnyav		Kev kis mob hnyav
Lub cev hnyav (kg)	Hnub nyoog (kwv yees)	125 mg + 31.25 mg / 5 ml	250 mg + 62.5 mg / 5 ml	125 mg + 31.25 mg / 5 ml	250 mg + 62.5 mg / 5 ml
5-10	3-12 hlis	3 × 2.5 ml (1/2 liter.)	3 × 1.25 ml (1/4 l.)	3 × 3.75 ml (3/4 l.)	3 × 2 ml (1/4 - 1/2 liter.)
10-12	1-2 xyoos	3 × 3.75 ml (3/4 l.)	3 × 2 ml (1/4 - 1/2 liter.)	3 × 6.25 ml (1 1/4 l.)	3 × 3 ml (1/2 - 3/4 L.)
12-15	2-4 xyoos	3 × 5 ml (1 l.)	3 × 2.5 ml (1/2 liter).	3 × 7.5 ml (1 1/2 l.)	3 × 3.75 ml (3/4 l.)
15-20	4-6 xyoos	3 × 6.25 ml (1 1/4 l.)	3 × 3 ml (1/2 - 3/4 L.)	3 × 9,5 ml (1 3/4 -2 l.)	3 × 5 ml (1 l.)
20-30	6-10 xyoo	3 × 8.75 ml (1 3/4 L.)	3 × 4,5 ml (3/4 -1 l.)	-	3 × 7 ml (1 1/4 -1 1/2 l.)
30-40	10-12 xyoo	-	3 × 6.5 ml (1 1/4 l.)	-	3 × 9,5 ml (1 3/4 -2 l.)
≥ 40	≥ 12 xyoos	Amoxiclav prescribed raug kho hauv cov ntsiav tshuaj

Cov koob tshuaj txhua hnub ntawm kev ncua ntawm 400 mg + 57 mg / 5 ml tau suav rau 1 kg ntawm lub cev qhov hnyav nce raws qhov hnyav ntawm tus mob thiab yog 25-45 mg / kg lub cev hnyav / hnub (hauv amoxicillin), muab faib ua 2 koob.

Txhawm rau kom muaj kev noj tshuaj kom zoo, ib qho kev txhaj tshuaj 400 mg + 57 mg / 5 ml raug tso rau hauv txhua pob ntawm cov raj xa dej, kawm tiav ib txhij hauv 1, 2, 3, 4, 5 ml thiab 4 qhov sib luag.

Pom zoo kom muab qhov ncua sij hawm nyob ntawm lub cev qhov hnyav ntawm tus menyuam thiab qhov mob hnyav tau kis.

Lub cev hnyav (kg)	Hnub nyoog (kwv yees)	Kev kis mob hnyav	Kab mob sib kis
5-10	3-12 hlis	2 × 2.5 ml (1/2 pipette)	2 × 1.25 ml (1/4 pipette)
10-15	1-2 xyoos	2 × 3.75 ml (3/4 pipettes)	2 × 2.5 ml (1/2 pipette)
15-20	2-4 xyoos	2 × 5 ml (1 pipette)	2 × 3.75 ml (3/4 pipettes)
20-30	4-6 xyoos	2 × 7.5 ml (1 1/2 pipettes)	2 × 5 ml (1 pipette)
30-40	6-10 xyoo	2 × 10 ml (2 pipettes)	2 × 6.5 ml (1 1/4 pipettes)

Cov koob tshuaj txhua hnub yog xam raws li lub cev qhov hnyav ntawm tus me nyuam, thiab tsis yog nws lub hnub nyoog.

Qhov koob tshuaj txhua hnub ntawm amoxicillin yog 6 g rau cov neeg laus, 45 mg / kg ntawm lub cev hnyav rau cov menyuam yaus.

Qhov siab tshaj plaws txhua hnub koob tshuaj clavulanic acid (hauv daim ntawv ntawm cov ntsev ntsev) yog 600 mg rau cov neeg laus thiab 10 mg / kg ntawm lub cev hnyav rau cov menyuam yaus.

Hauv cov neeg mob uas mob raum tsis zoo (CC tsawg dua 10 ml / min), qhov koob tshuaj yuav tsum tau txo qis txaus lossis qhov luv nruab nrab ntawm ob koob tshuaj yuav tsum tau nce (nrog anuria txog 48 teev lossis ntau dua).

Lub chav kawm ntawm kev kho mob yog 5-14 hnub. Lub sijhawm tiv thaiv ntawm kev kho mob yog txiav txim los ntawm tus kws khomob koom nrog. Txoj kev kho yuav tsum tsis pub ntev tshaj 14 hnub yam tsis muaj kev kuaj mob zaum ob.

Cov kev cai npaj rau ntawm kev npaj rau kev ncua ntawv

Hmoov rau qhov kev npaj tawm ntawm 125 mg + 31.25 mg / 5 ml: co lub raj mis sib zog, ntxiv 86 ml dej (rau qhov cim) hauv ob zaug, txhua lub sij hawm co zoo kom txog thaum cov hmoov yaj tas.

Hmoov rau qhov kev npaj tawm ntawm 250 mg + 62.5 mg / 5 ml: co lub raj mis kom khov, ntxiv dej 85 ml (txog li cim) hauv ob zaug, txhua lub sij hawm co zoo kom txog thaum cov hmoov yaj tas.

Hmoov rau qhov kev npaj tawm ntawm 400 mg + 57 mg / 5 ml: khov kho co lub raj mis, ntxiv dej hauv qhov nyiaj uas teev hauv daim ntawv qhia thiab qhia hauv lub rooj (rau qhov cim) hauv ob zaug, txhua lub sij hawm tshee zoo kom txog thaum cov hmoov yaj tag.

Vial loj	Qhov yuav tsum tau ntawm cov dej
35 ml	29,5 ml
50 ml	42 ml
70 ml	59 ml
140 ml	118 ml

Ua ntej siv, lub vial yuav tsum tau co khov kho.

Sab sij huam

Cov kev mob tshwm sim rau feem ntau me me thiab ua ntu zus.

Los ntawm cov txheej txheem hauv plab: poob qab los noj mov, xeev siab, ntuav, raws plab, tsis tshua muaj mob plab, ua rau lub siab ua haujlwm, muaj kev ua haujlwm ntawm daim siab ua haujlwm siab (ALT lossis AST), muaj qee zaum - cholestatic jaundice, mob siab, pseudomembranous colitis.

Kev tsis haum tshuaj: pruritus, urticaria, pob txuv erythematous, tsis tshua muaj - multiforme exudative erythema, angioedema, anaphylactic ceeb, kev tsis haum vasculitis, nyob rau hauv qee yam mob - exfoliative dermatitis, Stevens-Johnson syndrome, mob siab dav dav exanthematous pustulosis.

Los ntawm cov kab mob hemopoietic thiab cov lymphatic system: tsis tshua muaj - thim rov qab leukopenia (suav nrog neutropenia), thrombocytopenia, tsis tshua muaj - hemolytic anemia, thim rov qab lub sijhawm prothrombin (thaum ua ke nrog anticoagulants), eosinophilia, pancytopenia.

Los ntawm cov hlab ntsha hauv lub cev: kiv taub hau, mob taub hau, tsis tshua muaj - kev huam ywb (tuaj yeem tshwm sim hauv cov neeg mob uas lub raum tsis ua haujlwm thaum noj cov tshuaj hauv qhov siab), hyperactivity, ntxhov siab, insomnia.

Los ntawm cov kab mob urinary: tsis tshua muaj - interstitial nephritis, crystalluria.

Lwm yam: tsis tshua muaj tshwm sim - kev txhim kho ntawm superinfection (suav nrog candidiasis).

Cov Yuav Tsum Muaj

ua kom lub cev tsis haum rau ib qho twg ntawm cov tshuaj,
cov tshuaj tiv thaiv tsis haum hauv keeb kwm rau penicillins, cephalosporins thiab lwm yam tshuaj tua kab mob beta-lactam,
keeb kwm ua pov thawj ntawm cholestatic jaundice thiab / lossis lwm qhov ua kom lub siab ua tsis zoo los ntawm kev noj cov tshuaj amoxicillin / clavulanic acid,
mob mononucleosis thiab mob lyukhocytic.

Nrog ceev faj, koj yuav tsum siv cov tshuaj nrog keeb kwm pseudomembranous mob plab, nrog rau daim siab tsis ua hauj lwm, mob raum tsis zoo, zoo li thaum lactation.

Cov lus qhia tshwj xeeb

Nrog rau txoj kev kho mob, cov haujlwm ntawm cov ntshav, daim siab thiab lub raum yuav tsum tau saib xyuas.

Hauv cov neeg mob uas lub raum tsis ua haujlwm uas tsis zoo, yuav tsum tau kho txoj kev noj tshuaj ntau dua lossis nce ntxiv nyob nruab nrab ntawm kev noj tshuaj yog xav tau.

Txhawm rau kom txo qis kev phom sij los ntawm kev mob tshwm sim ntawm txoj hnyuv plab, cov tshuaj yuav tsum tau noj nrog pluas noj.

Kev ntsuam xyuas hauv chaw kuaj: cov tshuaj amoxicillin ntau heev muab qhov tsis zoo tsis haum rau cov ntshav qabzib thaum siv Benedict's reagent lossis Felling's solution. Peb nquahu kom muaj Enzymatic tshua nrog glucosidase.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Tsis muaj cov ntaub ntawv qhia txog qhov tshwm sim tsis zoo ntawm Amoxiclav nyob rau hauv koob tshuaj pom zoo kom muaj peev xwm tsav lub tsheb lossis ua haujlwm nrog cov qauv.

Noj ntau dhau

Tsis muaj xov xwm qhia txog kev tuag lossis kev phom sij txog lub neej txoj sia vim kev siv tshuaj ntau dhau.

Cov tsos mob: feem ntau, teeb meem ntawm lub plab zom mov (mob plab, raws plab, ntuav), ntxhov siab vim arousal, insomnia, kiv taub hau kuj muaj peev xwm, qee qhov mob ua rau qaug dab peg.

Kev Kho Mob: tus neeg mob yuav tsum nyob hauv qab kev saib xyuas mob, tsos mob kho mob. Nyob rau hauv cov ntaub ntawv ntawm kev tswj hwm tsis ntev los no ntawm cov tshuaj (tsawg dua 4 teev), nws yog ib qho tsim nyog los ntxuav lub plab thiab sau lub tshuab hluav ncaig kom txo qis kev nqus ntawm cov tshuaj. Amoxicillin / poov tshuaj clavunate raug tshem tawm los ntawm hemodialysis.

Amoxiclav raug ncua - cov lus qhia rau siv

Cov tshuaj muaj txiaj ntsig zoo heev ntawm cov tshuaj tau muab nws nrog lub koob npe nrov ua cov txhim khu kev qha tiv thaiv ntau pua tus ailments. Amoxiclav raug pom zoo los ntawm cov kws kho mob hauv tebchaws Russia thiab lwm lub tebchaws CIS. Txawm li cas los xij, yog tias siv tsis raug, cov tshuaj muaj peev xwm ua rau tib neeg lub cev. Txhawm rau tiv thaiv qhov ua yuam kev ntawd, ua ntej pib kho, nyeem cov lus qhia kom meej thiab sab laj nrog kws kho mob.

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj, muab cov tshuaj ua kom muaj zog - amoxicillin thiab clavulanic acid. Cov feem tiv thaiv kev loj hlob thiab rov ua dua ntawm cov tsiaj muaj teeb meem.Ntxiv rau lawv, cov muaj pes tsawg leeg muaj cov txheej txheem uas pab txhawb kom nqus tau cov tshuaj zoo dua los ntawm tib neeg lub cev:

anhydrous citric acid,
carmellose sodium
colloidal silicon dioxide,
sodium saccharin
anhydrous sodium citrate,
microcrystalline cellulose,
xanthan ntawm cov pos hniav,
sodium benzoate
silica
mannitol
flavorings (txiv qaub, strawberry, Cherry).

Pharmacodynamics thiab pharmacokinetics

Cov tshuaj yog nquag tiv thaiv ntau yam ntawm cov kab mob me:

aerobic gram-zoo thiab cov kab mob gram-tsis zoo,
anaerobic gram-zoo thiab cov kab mob gram-tsis zoo,
beta-lactamases ntawm hom II, III, IV, V (subspecies ntawm cov kab mob me me uas tiv taus qhov kev txiav txim ntawm amoxicillin tau txais txiaj ntsig zoo los ntawm kev muaj tshuaj lom neeg thib ob - clavulanic acid).

Tom qab noj cov kev ncua nyob rau sab hauv, cov yam muaj sia ntawm Amoxiclav yog nqus tau sai sai los ntawm cov qog ua kua rau ntawm txoj hnyuv hauv lub plab. Kev siv khoom noj zoo ib txhij tsis txo kev nqus, thiab yog li ntawd tsis tas yuav tsum thau tawm mus so ua ntej thiab tom qab noj mov. Lub sijhawm kom ncav cuag qhov kev siab tshaj plaws ntawm clavulanic acid thiab amoxicillin yog li 45 feeb. Kev siv rau kev noj tshuaj uas tus kws kho mob sau tseg, kev kho mob tsis ua mob rau lub cev. Amoxicillin cov khoom tawg yog cov tawm ntawm lub cev tsis pub dhau 10-15 hnub.

Nosological kev faib tawm (ICD-10)

Zaj duab xis-coated ntsiav tshuaj	1 tab.
cov tshuaj ua kom muaj zog (tseem ceeb):
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	250 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	125 mg
tus zam: colloidal silicon dioxide - 5.4 mg, crospovidone - 27,4 mg, croscarmellose sodium - 27.4 mg, magnesium stearate - 12 mg, talc - 13.4 mg, MCC - txog 650 mg
zaj duab xis sheath: hypromellose - 14.378 mg, ethyl cellulose 0.702 mg, polysorbate 80 - 0.78 mg, triethyl citrate - 0.793 mg, titanium dioxide - 7.605 mg, talc - 1.742 mg

Zaj duab xis-coated ntsiav tshuaj	1 tab.
cov tshuaj ua kom muaj zog (tseem ceeb):
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	500 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	125 mg
tus zam: colloidal silicon dioxide - 9 mg, crospovidone - 45 mg, croscarmellose sodium - 35 mg, magnesium stearate - 20 mg, MCC - txog 1060 mg
zaj duab xis sheath: hypromellose - 17.696 mg, ethyl cellulose - 0.864 mg, polysorbate 80 - 0.96 mg, triethyl citrate - 0.976 mg, titanium dioxide - 9.36 mg, talc - 2.144 mg

Zaj duab xis-coated ntsiav tshuaj	1 tab.
cov tshuaj ua kom muaj zog (tseem ceeb):
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	875 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	125 mg
tus zam: colloidal silicon dioxide - 12 mg, crospovidone - 61 mg, croscarmellose sodium - 47 mg, magnesium stearate - 17.22 mg, MCC - txog 1435 mg
zaj duab xis sheath: hypromellose - 23.226 mg, ethyl cellulose - 1.134 mg, polysorbate 80 - 1.26 mg, triethyl citrate - 1.28 mg, titanium dioxide - 12.286 mg, talc - 2.814 mg

Hmoov rau kev tshem tawm ntawm qhov ncauj	5 ml tshem tawm
yam tshuaj:
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	125 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	31,25 mg
tus zam: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, MCC thiab sodium carmellose - 28.1 mg, xanthan ntawm cov pos hniav - 10 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0.217 g, sodium saccharinate - 5.5 mg, mannitol - 1250 mg, txiv pos nphuab - 15 mg

Hmoov rau kev tshem tawm ntawm qhov ncauj	5 ml tshem tawm
yam tshuaj:
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	250 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	62,5 mg
tus zam: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, MCC thiab sodium carmellose - 28.1 mg, xanthan ntawm cov pos hniav - 10 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0.217 g, sodium saccharinate - 5.5 mg, mannitol - 1250 mg, txiv lws suav tsw - 4 mg

Hmoov rau kev tshem tawm ntawm qhov ncauj	5 ml tshem tawm
yam tshuaj:
amoxicillin (nyob rau hauv daim ntawv ntawm trihydrate)	400 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	57 mg
tus zam: citric acid (anhydrous) - 2.694 mg, sodium citrate (anhydrous) - 8.335 mg, MCC thiab carmellose sodium - 28,1 mg, xanthan ntawm cov pos hniav - 10 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0.217 g, kua txiv qab zib - 4 mg, txiv qaub tsw - 4 mg, sodium saccharinate - 5.5 mg, mannitol - txog 1250 mg

Hmoov rau cov tshuaj rau kev tswj hwm dej khov	1 fl.
yam tshuaj:
amoxicillin (nyob rau hauv daim ntawv ntawm sodium ntsev)	500 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev)	100 mg

Hmoov rau cov tshuaj rau kev tswj hwm dej khov	1 fl.
yam tshuaj:
amoxicillin (nyob rau hauv daim ntawv ntawm sodium ntsev)	1000 mg
clavulanic acid (nyob rau hauv daim ntawv ntawm cov poov tshuaj ntsev).	200 mg

Cov ntsiav tshuaj tawg yooj yim	1 tab.
yam tshuaj:
amoxicillin trihydrate	574 mg
(sib npaug rau 500 mg ntawm amoxicillin)
poov tshuaj clavulanate	148,87 mg
(sib npaug rau 125 mg ntawm clavulanic acid)
tus zam: txuj lom sib xyaw ua liaj ua teb - 26 mg, tsw qab zib txiv kab ntxwv - 26 mg, aspartame - 6.5 mg, colloidal silicon dioxide anhydrous - 13 mg, hlau (III) oxide daj (E172) - 3.5 mg, talc - 13 mg, castor roj hydrogenated - 26 mg, silicon-muaj MCC - txog 1300 mg

Cov ntsiav tshuaj tawg yooj yim	1 tab.
yam tshuaj:
amoxicillin trihydrate	1004.50 mg
(sib npaug rau 875 mg ntawm amoxicillin)
poov tshuaj clavulanate	148,87 mg
(sib npaug rau 125 mg ntawm clavulanic acid)
tus zam: txuj lom sib xyaw ua liaj ua teb - 38 mg, tsw qab zib txiv kab ntxwv - 38 mg, aspartame - 9.5 mg, colloidal silicon dioxide anhydrous - 18 mg, hlau (III) oxide daj (E172) - 5.13 mg, talc - 18 mg, castor roj hydrogenated - 36 mg, silicon-MCC muaj - txog 1940 mg

Kev ntsuas rau siv

Amoxiclav hmoov pom zoo nyob rau hauv rooj plaub uas tsim nyog los tawm tsam kev kis mob los ntawm cov kab mob me me ntawm cov leeg mob rhiab. Cov no suav nrog:

kis kab mob ntawm cov pa nraub qaum thiab cov kabmob ENT (mob ntev thiab mob hlab ntsws, mob pharyngeal ua paug, pharyngitis, tonsillitis, otitis media),
cov kab mob sib kis ntawm cov pa hauv qab qis (daim ntawv mob txha caj qaum nrog kev tiv thaiv cov kab mob superinfection, mob ntsws, thiab lwm yam),
cov kab mob gynecological
mob txeeb zig
kis kab mob ntawm daim tawv nqaij thiab cov nqaij mob sib txuas,
cov nqaij mos thiab tawv nqaij mob (nrog rau cov neeg thiab tsiaj).
odontogenic tau tus kab mob
biliary huam mob (cholangitis, cholecystitis).

Kev piav qhia ntawm daim ntawv tshuaj

250 + 125 mg ntsiav tshuaj: dawb los yog yuav luag dawb, oblong, octagonal, biconvex, zaj duab xis-txheej, nrog luam tawm ntawm "250/125" ntawm ib sab thiab "AMC" ntawm lwm sab.

500 + 125 mg ntsiav tshuaj: dawb lossis yuav luag dawb, oval, biconvex, zaj duab xis-txheej.

Ntsiav tshuaj 875 + 125 mg: dawb los yog yuav luag dawb, oblong, biconvex, zaj duab xis-txheej, nrog kev tshaj tawm thiab ua rau pom “875” thiab “125” ntawm ib sab thiab “AMC” ntawm lwm sab.

Saib rau ntawm kink: daj kom loj.

Hmoov rau kev tshem tawm hauv qhov ncauj: hmoov los ntawm dawb dawb mus rau daj dawb. Kev tshem tawm tiav yog ib qho kev ncua ntawm homogeneous los ntawm yuav luag dawb rau daj.

Hmoov rau qhov kev npaj ntawm kev daws rau iv tswj hwm: los ntawm dawb mus rau daj dawb.

Cov ntsiav tshuaj uas tawg: oblong, octagonal, lub teeb daj nrog ib txaws ntawm xim av, nrog tus ntxhiab tsw tsw qab.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub thiab lactation, Amoxiclav ® tsuas yog siv yog tias xav tias yuav muaj txiaj ntsig zoo rau leej niam tshaj qhov kev pheej hmoo rau tus menyuam thiab menyuam.

Amoxiclav ® Quicktab tuaj yeem siv tshuaj thaum cev xeeb tub yog tias muaj cov cim qhia meej.

Amoxicillin thiab clavulanic acid hauv ib qho me me txeem mus rau hauv niam cov kua mis.

Sab sij huam

Amoxiclav ® zaj duab xis-ntsiav tshuaj ntsiav tshuaj thiab hmoov rau qhov npaj ntawm kev daws rau iv kev tswj hwm

Los ntawm lub plab zom mov: tsis qab los noj mov, xeev siab, ntuav, raws plab, mob plab, gastritis, stomatitis, glossitis, tus nplaig "plaub hau" dub, tsaus nti txha hniav laus, hemorrhagic colitis (kuj tseem tuaj yeem tom qab kho), enterocolitis, pseudomembranous colitis, ua rau lub siab ua haujlwm tsis zoo, muaj kev ua haujlwm ntau ntxiv ALT, AST, alkaline phosphatase thiab / lossis ntshav plasma bilirubin qib, daim siab ua haujlwm (feem ntau ntawm cov neeg laus, cov txiv neej, nrog kev kho mob ntev), cholestatic jaundice, kab mob siab.

Kev tsis haum tshuaj: pruritus, urticaria, erythemous ua pob, erythema multiforme exudative, angioedema, anaphylactic shock, kev tsis haum vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, cov kab mob dav dav exanthematous pustulosis, cov tsos mob zoo ib yam li kev mob ntshav tawm, ua rau mob puas hlwb.

Los ntawm cov kab ke hemopoietic thiab cov lymphatic system: thim rov qab leukopenia (suav nrog neutropenia), mob thrombocytopenia, hemolytic anemia, thim rov qab nce hauv PV (thaum siv ua ke nrog anticoagulants), thim rov qab nce hauv lub sijhawm los ntshav, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis.

Los ntawm sab ntawm lub hauv nruab nrab hauv lub paj hlwb: kiv taub hau, mob taub hau, nriaj (tej zaum yuav tshwm sim rau cov neeg mob uas lub raum lub raum tsis ua haujlwm thaum noj tshuaj ntau).

Los ntawm cov kab mob urinary: interstitial nephritis, crystalluria, hematuria.

Lwm yam: candidiasis thiab lwm hom superinfection.

Rau cov yeeb yaj kiab-coated ntsiav tshuaj, hmoov rau tso tawm qhov ncauj, hmoov rau cov tshuaj hauv qhov ncauj ntxiv

Los ntawm sab ntawm lub hauv nruab nrab hauv lub paj hlwb: hyperactivity. Xav tias ntxhov siab, pw tsis tsaug zog, hloov pauv tus cwj pwm, arousal.

Amoxiclav ® Quicktab thiab Amoxiclav ® hmoov rau qhov ncauj ncua

Los ntawm cov kabmob hemopoietic plab thiab kabmob lymphatic: tsis tshua muaj - thim rov qab leukopenia (suav nrog neutropenia), thrombocytopenia, tsis tshua muaj tshwm sim - eosinophilia, thrombocytosis, thim rov qab agranulocytosis, kev nce ntshav hauv lub sijhawm thiab qhov thim rov qab hauv PV, ntshav tshuaj, suav nrog reversible hemolytic anemia.

Los ntawm lub nruab zog: qhov muaj ntau zaus tsis paub txog - mob hlwb, anaphylactic kev tsis haum, kev tsis haum vasculitis, ib yam mob zoo li mob ntshav dej.

Los ntawm lub paj hlwb: ua tsis tau zoo - kiv taub hau, mob taub hau, tsis tshua muaj - insomnia, ntxhov siab, ntxhov siab vim, tus cwj pwm hloov, thim rov qab hyperactivity, pov thawj, ua tsis taus pa tuaj yeem tshwm sim rau cov neeg mob uas tsis muaj mob lub raum, nrog rau cov neeg uas tau txais siab ntau ntawm cov tshuaj.

Los ntawm cov hnyuv: feem ntau - tsis qab los noj mov, xeev siab, ntuav, raws plab. Xeev siab yog tshwm sim muaj ntau dua thaum noj cov koob tshuaj loj. Yog tias mob plab zom mov tau paub tseeb, lawv tuaj yeem tshem tawm yog tias cov tshuaj noj thaum noj mov, ua rau kis tsis zoo - txiav tawm lub plab, tsis tshua muaj cov tshuaj tua kab mob ntsig txog kev mob plab los ntawm cov tshuaj tua kab mob (suav nrog pseudomembranous thiab hemorrhagic colitis), tus nplaig plaub hau dub, mob plab mob plab. Hauv cov menyuam yaus, qhov pom ntawm txheej txheej ntawm txheej hniav txha hniav laus yog qhov tsis tshua pom muaj tshwm sim. Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob muaj qhov sib txawv ntawm tus hniav txha hniav laus.

Ntawm feem ntawm daim tawv nqaij: tsis haum - tawv nqaij ua pob khaus, khaus, urticaria, tsis tshua muaj - multiforme exudative erythema, tsis paub ntau zaus - Stevens-Johnson syndrome, lom ua mob rau daim tawv nqaij, ua mob rau cov tawv nqaij, ua kom tawv nqaij mob, ua rau mob ua paug, ua kom muaj mob.

Los ntawm cov kab mob urinary: tsawg kawg - crystalluria, interstitial nephritis, hematuria.

Nyob rau ib feem ntawm daim siab thiab kais plab: ua tsis tau - kev ua haujlwm ntau ntawm ALT thiab / lossis AST (qhov tshwm sim no tau pom nyob rau hauv cov neeg mob tau txais kev kho mob beta-lactam, tab sis nws qhov tseem ceeb hauv cov chaw kho mob tsis paub), cov xwm txheej tsis zoo los ntawm daim siab raug pom muaj feem ntau hauv cov txiv neej thiab cov neeg laus thiab yuav muaj feem nrog kev kho mob mus ntev. Cov xwm txheej tsis zoo no tsis tshua pom muaj hauv cov menyuam yaus.

Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, txawm li cas los xij qee zaum qee zaum lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Cov xwm txheej tsis zoo yog cov thim rov qab. Kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, muaj qee qhov tsis tshua muaj neeg ceeb toom kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg mob uas mob nyhav los yog cov neeg mob tau txais cov tshuaj hepatotoxic. Tsis tshua muaj tshwm sim - nce kev ua si ntawm alkaline phosphatase, nce qib ntawm bilirubin, kab mob siab, mob siab daj ntseg (sau tseg nrog cov kev kho mob nrog lwm tus penicillins thiab cephalosporins).

Lwm yam: feem ntau - candidiasis ntawm daim tawv nqaij thiab mucous daim nyias nyias, qhov zaus tsis paub meej - kev loj hlob ntawm cov kab mob insensitive.

Kev sib txuam

Rau txhua daim ntawv qhia

Antacids, glucosamine, laxatives, aminoglycosides qeeb qeeb nqus, ascorbic acid nce ntxiv nqus.

Diuretics, allopurinol, phenylbutazone, NSAIDs thiab lwm yam tshuaj thaiv cov hlab zais pa (probenecid) ua rau kom muaj kev cia siab ntawm amoxicillin (clavulanic acid yog tawm los ntawm glomerular pom).

Kev siv tib lub sijhawm ntawm Amoxiclav ® thiab methotrexate ntau ntxiv cov tshuaj lom ntawm methotrexate.

Qhov kev teem sijhawm ua ke nrog allopurinol ua rau muaj qhov tshwj xeeb exanthema. Txuag siv nrog disulfiram yuav tsum zam.

Txo qhov ua tau zoo ntawm cov tshuaj, thaum lub cev metabolism uas PABA tsim, ethinyl estradiol - qhov kev pheej hmoo ntawm kev so tsis los ntshav.

Cov ntawv sau piav qhia tsis tshua muaj xwm txheej ntawm kev nce INR hauv cov neeg mob uas siv cov acenocumarol lossis warfarin thiab amoxicillin. Yog tias tsim nyog, siv ib txhij nrog cov tshuaj tiv thaiv kev tiv thaiv, PV lossis INR yuav tsum tau ua tib zoo saib xyuas thaum sau ntawv lossis txiav cov tshuaj.

Kev sib xyaw nrog rifampicin yog antagonistic (kev sib nrig sib tiv thaiv ntawm cov nyhuv antibacterial). Amoxiclav ® yuav tsum tsis txhob siv nyob rau hauv kev sib xyaw ua ke nrog cov tshuaj tua kab mob bacteriostatic (macrolides, tetracyclines), sulfonamides vim tias muaj peev xwm txo qis Amoxiclav effectiveness.

Amoxiclav ® txo qis kev ua tau zoo ntawm kev tiv thaiv qhov ncauj.

Rau cov ntsiav tshuaj uas siv tawg thiab cov hmoov sib xyaw rau kev ncua rau kev tswj hwm qhov ncauj ntxiv

Tsub kom muaj txiaj ntsig ntawm qhov tsis ncaj ntawm anticoagulants (suppressing lub plab hnyuv microflora, txo cov synthesis ntawm vitamin K thiab prothrombin index). Muaj qee kis, noj cov tshuaj tuaj yeem ntev dua qhov PV, hauv qhov no, kev ceev faj yuav tsum tau siv thaum siv cov tshuaj tiv thaiv thiab cov tshuaj Amoxiclav ® Quicktab.

Probenecid txo qis kev zoo ntawm amoxicillin, ua rau muaj kev paub ntau ntxiv.

Hauv cov neeg mob tau txais mycophenolate mofetil, tom qab pib siv kev sib xyaw ntawm amoxicillin nrog clavulanic acid, qhov kev txo qis ntawm cov tshuaj lom neeg metabolite, mycophenolic acid, tau pom ua ntej noj cov tshuaj ntxiv ntawm kwv yees li 50%. Kev hloov pauv hauv qhov kev nkag siab no tsis tuaj yeem cuam tshuam txog qhov hloov pauv ntawm kev cuam tshuam ntawm cov mycophenolic acid.

Rau cov hmoov ua ntej npaj ntawm kev daws rau iv kev tswj hwm

Cov tshuaj tua kab mob Amoxiclav ® thiab aminoglycoside yog tshuaj tsis sib xws.

Tsis txhob sib xyaw Amoxiclav ® rau hauv lub taub tshuaj lossis tshuaj lub raj mis nrog lwm yam tshuaj.

Zam kev sib xyaw nrog cov kev daws teeb meem ntawm dextrose, dextran, sodium bicarbonate, nrog rau cov kev daws teeb meem uas muaj ntshav, protein, lipids.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv Amoxiclav simultane sib xyaw nrog antacids, glucosamine, laxatives, aminoglycosides, kev nqus poob qis, nrog ascorbic acid nws nce.

Diuretics, allopurinol, phenylbutazone, NSAIDs thiab lwm yam tshuaj uas thaiv cov hlab zais pa zais ua rau muaj kev cia siab ntawm amoxicillin (clavulanic acid raug cais tawm tshwj xeeb los ntawm glomerular pom).

Nrog rau kev siv tib txhij ntawm Amoxiclav ® nce lub tshuaj lom ntawm methotrexate.

Nrog rau kev siv tib txhij ntawm Amoxiclav nrog allopurinol, qhov tshwm sim ntawm exanthema nce.

Muab kev tswj hwm nrog disulfiram yuav tsum raug zam.

Qee qhov xwm txheej, kev noj tshuaj tuaj yeem ncua sijhawm lub sijhawm prothrombin ntau ntxiv, hauv qhov no, yuav tsum ceev faj thaum siv tshuaj tiv thaiv anticoagulants thiab cov tshuaj Amoxiclav ®.

Kev sib xyaw ntawm amoxicillin nrog rifampicin yog antagonistic (muaj kev sib txuam ntawm lub zog tiv thaiv kab mob).

Amoxiclav ® yuav tsum tsis txhob siv ib txhij nrog cov tshuaj tua kab mob bacteriostatic (macrolides, tetracyclines), sulfonamides vim tias qhov txo qis hauv Amoxiclav kev ua haujlwm tau zoo.

Probenecid txo qis kev zoo ntawm amoxicillin, ua rau muaj kev paub ntau ntxiv.

Cov tshuaj tua kab mob txo qhov ua tau zoo ntawm kev tiv thaiv qhov ncauj.

Tsuas tshuaj thiab tswj hwm

Zaj duab xis-coated ntsiav tshuaj

Sab hauv. Kev noj tshuaj rau lub cev yog tsim tshwj xeeb, nyob ntawm seb muaj hnub nyoog, hnyav lub cev, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav npaum li cas.

Amoxiclav ® raug nquahu kom noj thaum pib noj mov kom zoo rau kev nqus thiab kom txo kev phiv los ntawm lub plab zom mov.

Cov koob tshuaj yog tshuaj raws lub hnub nyoog thiab lub cev hnyav. Cov tshuaj pom zoo kom noj yog 40 mg / kg / hnub hauv 3 koob tshuaj.

Cov menyuam yaus uas lub cev nyhav txog 40 kg lossis ntau dua yuav tsum txhaj tib yam li cov neeg laus. Rau cov menyuam yaus hnub nyoog ≤6 xyoo, nws yog qhov zoo dua los txhawm rau tshem tawm Amoxiclav a.

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos (lossis> 40 kg ntawm lub cev qhov hnyav)

Cov koob tshuaj ib txwm muaj thaum mob sib khuav xwb los yog mob me yog 1 ntsiav tshuaj. 250 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj. 500 + 125 mg txhua 12 teev, nyob rau kis mob hnyav thiab mob ntsws ua pa - 1 rooj. 500 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj. 875 + 125 mg txhua 12 teev

Txij li thaum ua ke cov ntsiav tshuaj ntawm amoxicillin thiab clavulanic acid 250 + 125 mg thiab 500 + 125 mg txhua tus muaj tib cov tshuaj clavulanic acid - 125 mg, tom qab ntawd 2 ntsiav tshuaj. 250 + 125 mg tsis sib npaug rau 1 ntsiav tshuaj. 500 + 125 mg.

Dosage rau odontogenic tau tus kab mob

1 tab. 250 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj. 500 + 125 mg txhua 12 teev rau 5 hnub.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov pauv koob yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin thiab raug coj los txiav txim siab Cl creatinine qhov tseem ceeb:

- cov neeg laus thiab menyuam yaus hnub nyoog dhau 12 xyoos (lossis ≥40 kg ntawm lub cev qhov hnyav) (cov lus. 2),

- nrog anuria, lub sijhawm nruab nrab ntawm kev txhaj tshuaj yuav tsum tau nce mus rau 48 teev lossis ntau dua,

- 875 + 125 mg ntsiav tshuaj yuav tsum tsuas yog siv rau hauv cov neeg mob nrog Cl creatinine> 30 ml / min.

Creatinine kev tshem tawm	Amoxiclav age ntau npaum tshuaj
> 30 ml / min	Tsis tas yuav txhaj koob tshuaj
10-30 ml / feeb	1 tab. 50 + 125 mg 2 zaug hauv ib hnub lossis 1 ntsiav tshuaj. 250 + 125 mg (nrog rau mob me mus rau mob hnyav) 2 zaug ib hnub
Yuav tsum ua nrog ceev faj. Kev tshuaj xyuas daim siab ua haujlwm yog tsim nyog.

Hmoov rau kev tshem tawm ntawm qhov ncauj

Kev noj hno tshuaj txhua hnub yog 125 + 31.25 mg / 5 ml thiab 250 + 62.5 mg / 5 ml (los pab txhawb kev noj kom haum, hauv txhua pob ntawm kev ncua 125 + 31.25 mg / 5 ml thiab 250 + 62.5 mg / 5 ml, 5 ml kawm tiav pipette nrog 0.1 ml nplai los yog 5 ml ntau rab diav, yog ntxig rau annular cov cim hauv kab noj hniav ntawm 2.5 thiab 5 ml).

Menyuam mos thiab menyuam muaj txog li 3 hlis - 30 mg / kg / hnub (raws li amoxicillin), muab faib ua 2 koob tshuaj (txhua 12 teev).

Kev noj tshuaj ntawm Amoxiclav ® nrog rau lub koob tshuaj - suav txog ib koob tshuaj txhawm rau kho tus mob hauv cov menyuam mos thiab menyuam hnub nyoog txog 3 hlis (Daim Ntawv 3).

Lub cev hnyav	2	2,2	2,4	2,6	2,8	3	3,2	3,4	3,6	3,8	4	4,2	4,4	4,6	4.8
Ncua 156,25 ml (2 zaug hauv ib hnub)	1,2	1,3	1,4	1,6	1,7	1,8	1,9	2	2,2	2,3	2,4	2,5	2,6	2,8	2,9
Ncua 312,5 ml (2 zaug hauv ib hnub)	0,6	0,7	0,7	0,8	0,8	0,9	1	1	1,1	1,1	1,2	1,3	1,3	1,4	1,4

Cov menyuam yaus hnub nyoog loj dua 3 hlis - los ntawm 20 mg / kg rau kev kis mob ntawm mob sib khuav me txog qib nruab nrab mus rau 40 mg / kg rau kev kis mob hnyav thiab txo qis ntawm txoj hlab pa, otitis media, sinusitis (amoxicillin) ib hnub, muab faib ua 3 koob (txhua 8 teev).

Kev noj tshuaj ntawm Amoxiclav ® nrog lub koob tshuaj pipette - suav txog ib koob tshuaj txhawm rau kho tus mob me thiab mob nyhav rau cov menyuam yaus hnub nyoog qis dua 3 hlis (raws li 20 mg / kg / hnub (rau amoxicillin) (Cov Lus 4).

Lub cev hnyav	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22
Ncua 156,25 ml (3 zaug hauv ib hnub)	1,3	1,6	1,9	2,1	2,4	2,7	2,9	3,2	3,5	3,7	4	4,3	4,5	4,8	5,1	5,3	5,6	5,9
Ncua 312,5 ml (3 zaug hauv ib hnub)	0,7	0,8	0,9	1,1	1,2	1,3	1,5	1,6	1,7	1,9	2	2,1	2,3	2,4	2,5	2,7	2,8	2,9
Lub cev hnyav	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39
Ncua 156,25 ml (3 zaug hauv ib hnub)	6,1	6,4	6,7	6,9	7,2	7,5	7,7	8	8,3	8,5	8,8	9,1	9,3	9,6	9,9	10,1	10,4
Ncua 312,5 ml (3 zaug hauv ib hnub)	3,1	3,2	3,3	3,5	3,6	3,7	3,9	4	4,1	4,3	4,4	4,5	4,7	4,8	4,9	5,1	5,2

Kev noj tshuaj ntawm Amoxiclav ® nrog rau lub raj tshuaj loj - suav txog ib koob tshuaj kho mob rau cov menyuam muaj hnub nyoog laus dua 3 hlis (raws li 40 mg / kg / hnub (rau amoxicillin) (Cov Lus 5).

Lub cev hnyav	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22
Ncua 156,25 ml (3 zaug hauv ib hnub)	2,7	3,2	3,7	4,3	4,8	5,3	5,9	6,4	6,9	7,5	8	8,5	9,1	9,6	10,1	10,7	11,2	11,7
Ncua 312,5 ml (3 zaug hauv ib hnub)	1,3	1,6	1,9	2,1	2,4	2,7	2,9	3,2	3,5	3,7	4	4,3	4,5	4,8	5,1	5,3	5,6	5,9
Lub cev hnyav	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39
Ncua 156,25 ml (3 zaug hauv ib hnub)	12,3	12,8	13,3	13,9	14,4	14,9	15,5	16	16,5	17,1	17,6	18,1	18,7	19,2	19,7	20,3	20,8
Ncua 312,5 ml (3 zaug hauv ib hnub)	6,1	6,4	6,7	6,9	7,2	7,5	7,7	8	8,3	8,5	8,8	9,1	9,3	9,6	9,9	10,1	10,4

Kev noj tshuaj ntawm cov tshuaj Amoxiclav spoon nrog cov tshuaj noj me me (hauv qhov tsis nco qab cov raj xa dej) - koob tshuaj pom zoo ntawm kev ncua kev kawm nyob ntawm lub cev qhov hnyav ntawm tus menyuam thiab qhov mob kis loj (Cov Lus 6)

Lub cev hnyav	Hnub nyoog (kwv yees)	Tsis hais mentsis / theem nrab		Txoj kev kawm nyav
Lub cev hnyav	Hnub nyoog (kwv yees)	125 + 31.25 mg / 5 ml	250 + 62.5 mg / 5 ml	125 + 31.25 mg / 5 ml	250 + 62.5 mg / 5 ml
5–10	3-12 hlis	3 × 2.5 ml (½ tablespoon)	3 × 1.25 ml	3 × 3.75 ml	3 × 2 ml
10–12	1-2 xyoos	3 × 3.75 ml	3 × 2 ml	3 × 6.25 ml	3 × 3 ml
12–15	2-4 xyoos	3 × 5 ml (1 diav)	3 × 2.5 ml (½ tablespoon)	3 × 7.5 ml (1½ diav)	3 × 3.75 ml
15–20	4-6 xyoos	3 × 6.25 ml	3 × 3 ml	3 × 9,5 ml	3 × 5 ml (1 diav)
20–30	6-10 xyoo	3 × 8.75 ml	3 × 4,5 ml	-	3 × 7 ml
30–40	10-12 xyoos	-	3 × 6.5 ml	-	3 × 9,5 ml
≥40	≥12 xyoos	Amoxiclav ® ntsiav tshuaj

Cov koob tshuaj niaj hnub raug tshem tawm 400 mg + 57 mg / 5 ml

Qhov tshuaj tau muab xam rau ib kg ntawm lub cev hnyav, nyob ntawm seb qhov mob hnyav npaum li cas. Los ntawm 25 mg / kg rau kev kis mob me me mus rau mob hnyav mus rau 45 mg / kg rau kev kis mob hnyav thiab qis ntsws ua pa, mob otitis media, sinusitis (hais txog amoxicillin) ib hnub, muab faib ua 2 koob tshuaj.

Raug tshem tawm txog 400 mg + 57 mg / 5 ml yog siv rau hauv cov menyuam yaus hnub nyoog ntau dua 3 hlis.

Pom zoo kom muab koob hno raws li tus menyuam qhov hnyav lub cev thiab qhov kis mob hnyav

Lub cev hnyav	Hnub nyoog (kwv yees)	Pom zoo Koob tshuaj, ml
Lub cev hnyav	Hnub nyoog (kwv yees)	Txoj kev kawm nyav	Ntsig txog kev kawm
5–10	3-12 hlis	2×2,5	2×1,25
10–15	1-2 xyoos	2×3,75	2×2,5
15–20	2-4 xyoos	2×5	2×3,75
20–30	4 xyoos - 6 xyoos	2×7,5	2×5
30–40	6-10 xyoo	2×10	2×6,5

Cov koob tshuaj txhua hnub yog xam raws li lub cev qhov hnyav ntawm tus me nyuam, thiab tsis yog nws lub hnub nyoog.

Qhov koob tshuaj txhua hnub ntawm amoxicillin yog 6 g rau cov neeg laus thiab 45 mg / kg rau cov menyuam yaus.

Qhov siab tshaj plaws txhua hnub koob tshuaj clavulanic acid (hauv daim ntawv ntawm cov poov tshuaj ntsev) yog 600 mg rau cov neeg laus thiab 10 mg / kg rau cov menyuam yaus.

Hauv cov neeg mob uas lub raum tsis ua haujlwm, qhov koob tshuaj yuav tsum tau ua raws li qhov ntau tshaj plaws ntawm kev tso cai ntawm amoxicillin.

Cov neeg mob uas muaj creatinine Cl> 30 ml / min tsis tas yuav tsum tau kho ib koob.

Cov neeg laus thiab menyuam yaus hnyav dua 40 kg (qhia txog kev noj tshuaj yog siv rau kev kis mob nyav thiab mob hnyav)

Cov neeg mob nrog Cl creatinine 10-30 ml / min - 500/125 mg 2 zaug ib hnub.

Thaum Cl creatinine Cl creatinine 10-30 ml / min, koob tshuaj pom zoo yog 15 / 3.75 mg / kg 2 zaug hauv ib hnub (ntau tshaj 500/125 mg 2 zaug hauv ib hnub).

Nrog Cl creatinine iv

Cov Menyuam: nrog lub cev qhov hnyav tsawg dua 40 kg - qhov koob tshuaj yog tau txiav txim siab nyob ntawm qhov hnyav hauv lub cev.

Tsawg dua 3 lub hlis nrog lub cev hnyav dua li 4 kg - 30 mg / kg (hauv qhov tseeb ntawm tag nrho cov tshuaj Amoxiclav ®) txhua 12 teev

Hauv qab 3 lub hlis nrog lub cev qhov hnyav ntau dua 4 kg - 30 mg / kg (hauv qhov tseeb ntawm tag nrho cov tshuaj Amoxiclav ®) txhua 8 teev

Hauv cov menyuam yaus hnub nyoog qis dua 3 lub hlis, Amoxiclav ® yuav tsum tsuas yog maj mam muab Txoj kev lis ntshav dhau ntawm 30-40 feeb.

Cov menyuam muaj 3 hlis txog 12 xyoos - 30 mg / kg (hauv qhov kev npaj ntawm tag nrho Amoxiclav ®) nrog lub sijhawm 8 teev, nyob rau kis mob hnyav - nrog lub sijhawm 6 teev

Cov menyuam uas lub raum tsis ua haujlwm

Kev hloov pauv koob yog nce raws li qhov xav tau ntau tshaj ntawm amoxicillin. Rau cov neeg mob nrog Cl creatinine saum toj no 30 ml / min, kev kho tshuaj tsis tsim nyog.

Cov menyuam yaus nyhav Cl creatinine 10-30 ml / min25 mg / 5 mg rau 1 kg txhua 12 teev Cl creatinine ® muaj 25 mg ntawm amoxicillin thiab 5 mg ntawm clavulanic acid.

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg - 1.2 g ntawm yeeb tshuaj (1000 + 200 mg) nrog ib ncua sijhawm ntawm 8 teev, thaum kis mob hnyav - nrog lub sijhawm ntev li 6 teev

Cov koob tshuaj tiv thaiv rau kev phais mob: 1.2 g nrog induction ntawm kev ua kom loog (nrog lub sijhawm phais tsawg dua 2 teev). Rau kev ua haujlwm ntev - 1.2 g rau 4 zaug hauv ib hnub.

Rau cov neeg mob uas lub raum tsis txaus, qhov koob tshuaj thiab / lossis qhov luv ntawm kev txhaj tshuaj ntawm cov tshuaj yuav tsum raug kho nyob ntawm seb qhov ntau ntawm tsis txaus:

Cl tus kheej	Koob tshuaj thiab / lossis ntu nyob nruab nrab ntawm kev tswj hwm
> 0.5 ml / s (30 ml / min)	Tsis tas yuav txhaj koob tshuaj
0.166–0.5 ml / s (10–30 ml / min)	Thawj koob tshuaj yog 1.2 g (1000 + 200 mg), thiab tom qab ntawd 600 mg (500 + 100 mg) iv txhua 12 teev
iv txhua 24 xuab moos
Kev Mob Nkeeg	Lub sijhawm noj tshuaj yuav tsum nce ntxiv mus rau 48 teev lossis ntau dua.

Txij li 85% ntawm cov tshuaj raug tshem tawm los ntawm hemodialysis, qhov kawg ntawm txhua tus txheej txheem hemodialysis, koj yuav tsum nkag mus rau ib txwm ntawm Amoxiclav dose. Nrog peritoneal lim ntshav, kev hloov kho koob tsis tas yuav tsum.

Lub chav kawm ntawm kev kho mob yog 5-14 hnub. Lub sijhawm tiv thaiv ntawm kev kho mob yog txiav txim los ntawm tus kws khomob koom nrog. Nrog rau qhov txo qis hauv cov tsos mob hnyav, hloov mus rau daim ntawv ntawm Amoxiclav oral raug pom zoo kom kho cov kev kho mob txuas ntxiv.

Kev npaj ntawm kev daws rau iv txhaj. Dhuav cov ntsiab lus ntawm lub vial hauv dej rau kev txhaj tshuaj: 600 mg (500 + 100 mg) hauv 10 ml dej rau kev txhaj tshuaj lossis 1.2 g (1000 + 200 mg) hauv 20 ml dej rau kev txhaj tshuaj. Hauv / hauv nkag mus nkag qeeb (hauv 3-4 feeb).

Amoxiclav ® yuav tsum tau tswj hwm hauv 20 feeb tom qab kev npaj ntawm kev daws teeb meem rau iv cov thawj coj.

Kev npaj ntawm kev daws rau iv Txoj kev lis ntshav. Rau Txoj kev lis ntshav ntawm Amoxiclav ®, ntxiv kev daws teeb meem yog qhov tsim nyog: cov kev npaj daws teeb meem uas muaj 600 mg (500 + 100 mg) lossis 1.2 g (1000 + 200 mg) ntawm cov tshuaj yuav tsum tau diluted hauv 50 lossis 100 ml ntawm Txoj kev lis ntshav daws, ntsig txog. Lub sijhawm ntawm Txoj kev lis ntshav yog 30-40 feeb.

Thaum siv cov kua hauv qab no hauv cov ntawv tso cai pom zoo hauv qhov kev daws teeb meem, qhov tsim nyog ntawm cov tshuaj tua kab mob tshwj xeeb tau muab khaws cia:

Siv dej ua kua	Lub Sijhawm ruaj khov, h
Siv dej ua kua	ntawm 25 ° C	ntawm 5 ° C
Dej rau kev txhaj tshuaj	4	8
0.9% kev daws sodium chloride rau iv infusion	4	8
Lub nplhaib qhov kev daws teeb meem ntawm lactate rau iv kev lis ntshav	3
Kev daws tshuaj calcium chloride thiab sodium chloride rau iv infusion	3

Kev daws ntawm cov tshuaj Amoxiclav ® tsis tuaj yeem xyaw nrog kev daws teebmeem ntawm dextrose, dextran lossis sodium bicarbonate.

Tsuas yog cov kev daws teeb meem meej meej yuav tsum tau siv. Npaj daws yuav tsum tsis txhob khov.

Sab hauv. Kev noj tshuaj yog tsim raws tus kheej lub hnub nyoog, lub cev nyhav, tus neeg mob lub raum kev ua haujlwm thiab qhov mob hnyav tau sib kis.

Cov ntsiav tshuaj yuav tsum tau yaj nyob hauv ib nrab khob dej (tsawg kawg 30 ml) thiab sib xyaw kom huv, tom qab ntawd haus los sis tuav cov ntsiav tshuaj hauv qhov ncauj kom txog thaum yaj tag, thiab tom qab ntawd nqos.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab zom mov, cov tshuaj yuav tsum tau noj thaum pib noj mov.

Amoxiclav ® Quicktab Dispersible ntsiav tshuaj 500 mg / 125 mg:

Cov neeg laus thiab cov menyuam yaus hnub nyoog 12 xyoos nrog lub cev hnyav ≥40 kg

Rau kev kho mob kis mob sib khuav ntawm me mus rau mob hnyav - 1 rooj. (500 mg / 125 mg) txhua 12 teev (2 zaug hauv ib hnub).

Rau kev kho mob ntawm kev mob hnyav thiab mob sib kis ntawm cov pa ua pa - 1 rooj. (500 mg / 125 mg) txhua 8 teev (3 zaug hauv ib hnub).

Qhov siab tshaj plaws niaj hnub noj ntawm Amoxiclav ® Quicktab yog 1,500 mg ntawm amoxicillin / 375 mg ntawm clavulanic acid.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Hauv cov neeg mob nrog creatinine Cl siab tshaj 30 ml / min, kev kho tshuaj tsis tsim nyog.

Cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos nrog lub cev hnyav ≥40 kg (qhov qhia kev noj tshuaj yog siv rau kev kis mob nyav thiab mob hnyav):

Cl creatinine, ml / min	Koob tshuaj
10–30	500 mg / 125 mg 2 zaug hauv ib hnub (nrog mob hnyav mus rau mob hnyav)
Quicktab 875 mg / 125 mg:

Cov neeg laus thiab cov menyuam yaus hnub nyoog 12 xyoos nrog lub cev hnyav ≥40 kg

Hauv kev mob hnyav thiab mob ua pa - 1 rooj. (875 mg / 125 mg) txhua 12 teev (2 zaug hauv ib hnub).

Cov koob tshuaj txhua hnub ntawm Amoxiclav ® Quicktab thaum siv 2 zaug hauv ib hnub yog 1750 mg ntawm amoxicillin / 250 mg ntawm clavulanic acid.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Hauv cov neeg mob nrog Cl creatinine ntau dua 30 ml / min, tsis tas yuav hloov tshuaj.

Rau cov neeg mob nrog Cl creatinine tsawg dua 30 ml / min, kev siv cov tshuaj sib kis tau ntawm cov tshuaj Amoxiclav ® Quicktab, 875 mg / 125 mg yog contraindicated.

Cov neeg mob zoo li no yuav tsum tau noj cov tshuaj ntawm kev noj tshuaj 500 mg / 125 mg tom qab tsim nyog kho qhov tsim nyog ntawm creatinine Cl.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo. Thaum noj cov Amoxiclav ® Quicktab, yuav tsum ceev faj. Kev tshuaj xyuas daim siab ua haujlwm yog tsim nyog. Thaum muaj kev kho mob pib nrog kev tswj hwm ntawm kev siv tshuaj, nws tuaj yeem txuas ntxiv kev kho nrog cov ntsiav tshuaj ntawm Amoxiclav ® Quicktab.

Lub sijhawm tiv thaiv ntawm kev kho mob yog txiav txim los ntawm tus kws kho mob koom nrog!

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub. Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj tau noj ntawm qhov ncauj. Tus nqi niaj hnub yog txiav txim siab los ntawm tus kws kho mob mus kawm, muab qhov mob hnyav thiab tus neeg mob lub cev qhov hnyav. Txhawm rau npaj cov kev ncua ntawm cov hmoov, koj yuav tsum co lub raj mis, hauv ob zaug ntxiv cov dej hauv dej tso rau ntawm daim ntawv, sib xyaw kom huv si. Lub hmoov yuav ua kom tiav kom ntev li ntawm 10-15 vib nas this thiab tau txais cov ua kua tuab. Txhawm rau kom nkag siab yuav ua li cas Amoxiclav, koj yuav tsum paub koj tus kheej nrog cov lus hauv qab no:

Lub cev hnyav	Hnub nyoog (kwv yees)	Lub teeb thiab mob sib kis		Kev kis mob hnyav
Lub cev hnyav	Hnub nyoog (kwv yees)	250 mg + 62.5 mg / 5 ml	125 mg + 31.25 mg / 5 ml	250 mg + 62.5 mg / 5 ml	125 mg + 31.25 mg / 5 ml
5-10	los ntawm 3 txog 12 hlis	3x2,5 ml	3x1.25 ml	3x3.75 ml	3x2 ml
10-12	los ntawm 1 txog 2 xyoos	3x3.75 ml	3x2 ml	3x6.25 ml	3x3 ml
12-15	los ntawm 2 txog 4 xyoos	3x5 ml	3x2,5 ml	3x3.75 ml	3x2.75 ml
15-20	los ntawm 4 rau 6 xyoo	3x6.25 ml	3x3 ml	3x9,5 ml	3x5 ml
20-30	los ntawm 6 txog 10 xyoo	3x8.75 ml	3x4,5 ml	-	3x7 ml
30-40	los ntawm 10 txog 12 xyoos	-	3x6,5 ml	-	3x9,5 ml
ntau dua 40	los ntawm 12 xyoo	Tshaj tawm hauv daim ntawv ntawm cov ntsiav tshuaj

Dosage daim ntawv

Hmoov rau kev tshem tawm ntawm qhov ncauj, 156.25 mg / 5 ml thiab 312,5 mg / 5 ml

5 ml ntawm kev ncua (1 tshuaj pipette) muaj

yam tshuaj: 125 mg amoxicillin li amoxicillin trihydrate + 5% tshaj rau kev ruaj khov 6.25 mg, 31.25 mg clavulanic acid li potassium clavulanate (rau kev noj tshuaj 156.25 mg / 5 ml) lossis 250 mg amoxicillin li amoxicillin trihydrate + 5% tshaj rau kev ruaj ntseg 12.5 mg, 62.5 mg clavulanic acid nyob rau hauv daim ntawv ntawm poov tshuaj clavulanate (rau kev noj tshuaj ntawm 312,5 mg / 5 ml).

zam txim: anhydrous citric acid, anhydrous sodium citrate, microcrystalline cellulose thiab sodium carboxymethyl cellulose, xanthan ntawm cov pos hniav, anhydrous colloidal silicon dioxide, silicon dioxide, Strawberry flavoring (rau ntau npaum ntawm 156.25 mg / 5 ml), Cherry flaving (rau ntau npaum ntawm 312,5 mg / 5 ml), sodium benzoate, sodium saccharin, qhuav, mannitol.

Crystalline hmoov los ntawm dawb mus rau lub teeb daj.

Qhov npaj ncua kev kawm yog qhov homogeneous kev ncua los ntawm yuav luag dawb rau daj.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Amoxicillin thiab clavulanic acid yog ua kom yaj tag hauv kev daws teeb meem ntawm pH ntawm lub cev. Ob qho khoom siv tau zoo nqus tom qab kev tswj hwm ntawm qhov ncauj. Nws yog qhov zoo dua rau noj amoxicillin / clavulanic acid lub sijhawm lossis thaum pib noj mov. Tom qab kev tswj hwm ntawm qhov ncauj, lub bioavailability ntawm amoxicillin thiab clavulanic acid yog kwv yees li 70%. Lub zog puab ntawm kev saib xyuas ntawm cov tshuaj nyob rau hauv lub plasma ntawm ob feem sib xyaw zoo ib yam nkaus. Qhov siab tshaj tawm cov dej siab tau mus txog 1 teev tom qab kev tswj hwm.

Qhov ntau ntawm amoxicillin thiab clavulanic acid nyob rau hauv cov ntshav ntshav thaum noj cov tshuaj amoxicillin / clavulanic acid ua ke yog zoo li cov tau pom nrog lub qhov ncauj cais cov tshuaj ntawm qhov sib npaug ntawm amoxicillin thiab clavulanic acid.

Txog 25% ntawm tag nrho cov nyiaj ntawm clavulanic acid thiab 18% ntawm amoxicillin khi rau cov ntshav protein. Qhov ntim ntawm kev faib tawm rau kev tswj hwm qhov ncauj ntawm cov tshuaj yog kwv yees 0.3-0.4 l / kg ntawm amoxicillin thiab 0.2 l / kg ntawm clavulanic acid.

Tom qab kev tswj hwm kev siv tshuaj, ob qho tib si amoxicillin thiab clavulanic acid tau pom nyob hauv lub zais zis, cov tawv nqaij ntawm lub plab hauv plab, tawv, rog, cov leeg nqaij, synovial thiab peritoneal kua, kua tsib thiab kua paug. Amoxicillin nkag mus rau hauv lub cev tsis zoo ua kua dej.

Amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv hniav. Ob seem puav leej sib kis mus rau niam mis.

Amoxicillin yog qee cov tso tawm hauv cov zis hauv daim ntawv ntawm tsis muaj zog penicillic acid hauv qhov sib npaug ntawm 10-25% ntawm thawj koob tshuaj. Clavulanic acid yog metabolized nyob rau hauv lub cev thiab nthuav tawm hauv cov zis thiab quav, ntxiv rau hauv cov qauv ntawm cov pa roj carbon dioxide nrog cov pa tawm ntawm huab cua.

Qhov nruab nrab kev tshem tawm ib nrab-lub neej ntawm amoxicillin / clavulanic acid yog li 1 teev, thiab qhov nruab nrab tag nrho kev sib tw yog kwv yees li 25 l / teev. Li ntawm 60-70% ntawm amoxicillin thiab 40-65% ntawm clavulanic acid raug tso tawm tsis hloov pauv hauv cov zis hauv thawj 6 teev tom qab noj ib qho tshuaj amoxicillin / clavulanic acid ntsiav tshuaj. Thaum lub sij hawm ntau cov kev tshawb fawb, nws tau pom tias 50-85% ntawm amoxicillin thiab 27-60% ntawm clavulanic acid tau tawm hauv cov zis hauv 24 teev. Qhov loj tshaj plaws ntawm clavulanic acid tau tawm hauv thawj 2 teev tom qab daim ntawv thov.

Kev siv ib txhij ntawm probenecid qeeb ua rau kev tso tawm ntawm amoxicillin, tab sis cov tshuaj no tsis cuam tshuam qhov cuam tshuam ntawm clavulanic acid los ntawm ob lub raum.

Ib nrab-lub neej ntawm amoxicillin zoo ib yam li cov menyuam yaus hnub nyoog 3 hlis txog 2 xyoos, tseem yog menyuam yaus thiab neeg laus. Thaum sau tshuaj rau cov menyuam yaus me (nrog rau cov menyuam mos thaum yug ntxov) nyob rau thawj lub lim tiam ntawm lub neej, cov tshuaj yuav tsum tsis txhob siv ntau dua ob zaug hauv ib hnub, uas cuam tshuam nrog kev hloov lub plawv tsis ua haujlwm ntawm cov menyuam yaus. Vim tias qhov tseeb tias cov neeg laus cov neeg mob feem ntau yuav mob lub raum tsis zoo, cov tshuaj yuav tsum tau txiav txim nrog ceev faj rau pawg neeg mob no, tab sis yog tias tsim nyog, kev tshuaj xyuas lub raum kev ua haujlwm yuav tsum tau ua.

Tag nrho kev tshem tawm ntawm amoxicillin / clavulanic acid nyob rau hauv cov ntshav txo qis hauv cov xaim ncaj qha rau ib qho kev txo qis hauv kev ua haujlwm. Qhov txo qis ntawm amoxicillin tshem tawm yog qhov tshaj tawm piv rau clavulanic acid, txij li ntau dua ntawm amoxicillin yog tawm dhau los ntawm lub raum. Yog li, thaum muab tshuaj rau cov neeg mob uas lub raum tsis ua haujlwm, yuav tsum tau txhaj tshuaj kho kom tsis txhob muaj cov tshuaj amoxicillin ntau ntau thiab tswj cov qib clavulanic acid yuav tsum tau ua.

Thaum muab tshuaj rau cov neeg mob uas lub siab tsis ua hauj lwm zoo, yuav tsum ceev faj thaum xaiv ib koob thiab soj ntsuam daim siab ua haujlwm tas li.

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog tshuaj tua kab mob ib nrab los ntawm pawg neeg penicillin (beta-lactam tshuaj tua kab mob) uas tiv thaiv ib lossis ntau tshaj li cov enzymes (feem ntau hu ua penicillin-khi cov protein) koom nrog biosynthesis ntawm peptidoglycan, uas yog cov txheej txheem tseem ceeb ntawm cov kab mob ntawm tes ua haujlwm. Kev txwv tsis pub peptidoglycan hluavtaws ua rau kev ua haujlwm tsis zoo ntawm lub xovtooj ntawm phab ntsa, feem ntau ua raws li cov cell lysis thiab cell tuag.

Amoxicillin raug pov tseg los ntawm beta-lactamases ua los ntawm cov kab mob tawm tsam, thiab, yog li ntawd, kev ua si spectrum ntawm amoxicillin ib leeg tsis suav nrog cov kab mob me me uas tsim cov enzymes no.

Clavulanic acid yog beta-lactam kev txuam nrog penicillins. Nws inhibits qee qhov beta-lactamases, yog li tiv thaiv qhov ua tsis tiav ntawm amoxicillin thiab nthuav nws cov kev ua haujlwm spectrum. Clavulanic acid nws tus kheej tsis muaj qhov chaw mos ua rau muaj kev cuam tshuam loj heev rau kev kho mob.

Tshaj lub sijhawm dhau los ntawm qhov kev txwv qis tshaj plaws (T> IPC) yog suav tias yog qhov kev txiav txim siab tseem ceeb ntawm cov hauj lwm zoo ntawm amoxicillin.

Ob txoj haujlwm tseem ceeb ntawm kev ua rau amoxicillin thiab clavulanic acid yog:

- kev tsis ua haujlwm los ntawm cov kab mob beta-lactamases uas tsis tau txais kev tiv thaiv los ntawm clavulanic acid, suav nrog cov chav kawm B, C thiab D.

- kev hloov pauv ntawm penicillin-khi cov protein, uas txo qis kev sib raug zoo ntawm cov tshuaj tua kab mob mus rau lub hom phiaj.

Lub zog tsis haum ntawm cov kab mob lossis cov txheej txheem ntawm lub efflux twj tso kua mis (thauj cov tshuab) tuaj yeem ua rau lossis tswj qhov tsis kam ntawm cov kab mob, tshwj xeeb tshaj yog cov kab mob gram-tsis zoo.

Chaw tsim tshuaj paus

Xaus dd Verovshkova 57, Ljubljana, Slovenia.

Rau cov hmoov ua kev npaj ntawm kev daws rau kev tswj hwm dej ntxiv rau

1. Lek dd, Verovshkova 57, Ljubljana, Slovenia.

2. Sandoz GmbH, Biohemistrasse 10 A-6250, Kundl, Austria.

Kev thov cov neeg tau txais kev pab yuav tsum tau xa mus rau Sandoz CJSC: 125317, Moscow, Presnenskaya nab., 8, p. 1.

Xov Tooj .: (495) 660-75-09, fax: (495) 660-75-10.

Amoxiclav ®

zaj duab xis-ntsiav tshuaj 250 mg + 125 mg 250 mg + 125 - 2 xyoos.

zaj duab xis-ntsiav tshuaj 500 mg + 125 mg 500 mg + 125 - 2 xyoos.

zaj duab xis-ntsiav tshuaj 875 mg + 125 mg 875 mg + 125 - 2 xyoos.

hmoov rau qhov kev npaj daws teeb meem rau kev saib xyuas ntawm 500 mg + 100 mg 500 mg + 100 - 2 xyoos.

hmoov rau qhov kev npaj daws ntawm kev daws rau kev tswj hwm ntawm 1000 mg + 200 mg 1000 mg + 200 - 2 xyoos.

cov tshuaj dispersible 500 mg + 125 mg 500 mg + 125 - 3 xyoos.

dispersible ntsiav tshuaj 875 mg + 125 mg 875 mg + 125 - 3 xyoos.

hmoov rau kev ncua kev tswj hwm ntawm qhov ncauj 125 mg + 31.25 mg / 5 ml 125 mg + 31.25 mg / 5 - 2 xyoos. Npaj ncua kev kawm - 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 250 mg + 62.5 mg / 5 ml 250 mg + 62.5 mg / 5 - 2 xyoos. Npaj ncua kev kawm - 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 3 xyoos. Npaj ncua kev kawm - 7 hnub.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Cov tshuaj sib cuam tshuam

Qhov ncauj anticoagulants thiab tshuaj tua kab mob ntawm cov penicillin pawg tau siv dav hauv kev coj ua yam tsis muaj ntawv ceeb toom ntawm kev sib cuam tshuam. Txawm li cas los xij, hauv cov ntawv nyeem tau muaj kev nce ntxiv hauv qhov kev hloov kho thoob ntiaj teb hauv cov neeg mob noj acenocoumarol lossis warfarin ua ke nrog amoxicillin. Yog tias kev siv tshuaj ib txhij yog tsim nyog, prothrombin lub sijhawm lossis tus tseev tsim ntiaj teb li qub yuav tsum tau ua tib zoo saib xyuas thaum kho mob thiab thim tawm cov tshuaj amoxicillin. Ntxiv mus, kev hloov pauv hauv qhov ntau npaum ntawm cov tshuaj tiv thaiv qhov ncauj yuav tsum tau.

Cov tshuaj Penicillin-pawg tuaj yeem txo qhov kev tshem tawm ntawm methotrexate, uas ua rau muaj kev nce ntxiv hauv lub cev tsis muaj tshuaj lom.

Tsis pom zoo siv cov tshuaj probenecid. Probenecid txo cov hlaus tubular zais zis ntawm amoxicillin. Concurrent siv nrog Amoxiclav tej zaum yuav ua rau kom muaj ntshav amoxicillin ntau ntau, tab sis tsis yog clavulanic acid.

Siv tib lub sijhawm ntawm allopurinol thiab Amoxiclav tuaj yeem ua rau muaj kev pheej hmoo tsis haum tshuaj. Cov ntaub ntawv hais txog kev siv txhij txhua ntawm allopurinol thiab amoxiclav tam sim no tsis muaj.

Hauv cov neeg mob noj mycophenolate mofetil, thaum ua ke nrog cov tshuaj Amoxiclav, qhov siab ntawm lub cev metabolite ntawm mycophenolic acid nrog rau kev pib siv yog txo los ntawm kwv yees li 50%. Ib qho kev hloov pauv ntawm qhov theem siab ntawm cov tshuaj thawj zaug yuav tsis haum rau kev hloov pauv hauv tag nrho cov tshuaj mycophenolic acid.

Daim ntawv tso tawm thiab ntim khoom

25 g ntawm hmoov tau muab tso rau hauv lub khob ntawm amber-kob iav lub khob uas muaj peev xwm ntawm 125 ml, corked nrog twisting yas kaus mom nrog kev tswj ntawm thawj qhib.

1 lub raj mis nrog lub taub tshuaj cov raj xa dej thiab cov lus qhia rau kev siv tshuaj kho mob hauv lub xeev thiab Lavxias lus yog muab tso rau hauv pob ntawv los qhia.

Thaum cev xeeb tub

Cov kev ua ntawm amoxicillin tiv thaiv cov kab mob tsis ua rau muaj kev phom sij rau tus me nyuam hauv plab, yog li ntawd, yog tias muaj qhov qhia tseeb, cov kws kho mob tau sau nws mus rau leej niam. Nws kuj tseem ceeb kom paub tias clavulanic acid thiab amoxicillin raug tso tawm hauv cov kua tsawg ua ke nrog niam mis. Qhov tshwm sim no tsis ua kev hem thawj, tab sis cov kws kho mob ib txwm soj ntsuam cov txheej txheem pub mis kom thiaj li zam dhau qhov pom tsis tau ntawm qhov tsis xav ntawm tus menyuam lub cev.

Amoxiclav rau menyuam yaus

Nws yooj yim dua rau lub cev hluas kom nqus tau cov tshuaj hauv cov ntawv ua kua. Hauv qhov no, Amoxiclav rau cov menyuam yaus (txog 12 xyoos) yog cov kws kho mob hauv cov menyuam yaus rau qhov kev txwv tsis pub ib homogeneous. Raug raws li ntau npaum, Amoxiclav tsis ua mob rau menyuam txoj kev noj qab haus huv. Qhov qub piv ntawm cov tshuaj ntim rau lub cev qhov hnyav yog 40 mg / kg. Qhov siab tshaj plaws tau tso cai rau noj txhua hnub yog 45 mg / kg. Txhawm rau kom zam dhau lub teeb meem, nws yuav tsum tsis txhob dhau. Hauv ntau dhau lawm, cov tshuaj tua kab mob Amoxiclav rau cov menyuam yaus yog qhov txaus ntshai heev.

Amoxiclav nqe

Ib qho tseem ceeb rau txhua tus neeg mob yog tus nqi ntawm cov tshuaj uas tus kws kho mob sau tseg. Cov kws kho mob tsis pom zoo kom txuag nyiaj rau kev noj qab haus huv, txawm li cas los xij, feem ntau nws yuav tau yuav ib cov tshuaj uas zoo ib yam li cov kab mob antibacterial pheej yig dua. Thaum muas cov tshuaj uas muaj cov nyhuv zoo sib xws, nco ntsoov sab laj nrog tus kws kho mob thiab kawm cov lus qhia rau kev siv. Txhawm rau kom nkag siab ntau npaum li cas Amoxiclav thiab nws tus nqi piv rau nqi, cov lus hauv qab no yuav pab tau:

Lub npe ntawm cov tshuaj	Tso Tawm Cov Ntawv	Nqe (hauv rubles)
Amoxiclav 2s	hmoov	96
Amoxiclav Quicktab	ntsiav tshuaj	127
Amoxicomb	hmoov	130
Amoxil-K	hmoov	37

Alexandra, 24 xyoo. Thaum muaj kev soj ntsuam mob ib txwm muaj, cov kws kho mob tau pom tus mob cholecystitis. Amoxiclav muab noj ntawm ncauj. Kuv nyeem kev txheeb xyuas hauv Is Taws Nem, Kuv txaus siab. Nws ua delicately, tus nqi yog tsim nyog. Tus kws kho mob tau pleev xim npaj sijhawm npaj noj, kho cov tshuaj ntawm amoxicillin. Nws hais tias lub cev muaj zog, neeg laus, yog li kev kho mob yuav tsis tuaj. Thiab yog li nws tau tshwm sim. Kuv zoo tu qab nyob hauv ib lub lis piam.

Victoria, 27 xyoo. Lub caij ntuj no cov duab hauv cov daus nqi ntau dhau - ntes caj pas mob. Tus kws kho mob tau hais tias kuv tau txo lub siab kev ua haujlwm, yog li kuv yuav tsum tau ua tib zoo saib xyuas. Tshaj tawm Amoxiclav 1000 hauv cov hmoov tshuaj. Hauv ib lub lis piam Kuv haus 10 ml ntawm kev ncua 3 zaug hauv ib hnub thiab txhua yam ploj mus. Los ntawm cov tshuaj tua kab mob, kuv lub siab ua rau mob ntau zaus, tab sis lub sijhawm no nws raug nqi. Qhov muaj pes tsawg leeg ntawm kev ncua yog pom los ntawm kuv lub cev ib txwm.

Victor, hnub nyoog 37 xyoo Lub Tsib Hlis, tus tub raug mob hauv tsev kho mob ntsws. Tus kws kho mob tau sau tshuaj rau cov tshuaj Amoxiclav raug muab tshem tawm 125. Vim yog muaj teeb meem nrog ntshav coagulation, kev teem caij ntawm anticoagulants yuav tsum ua. Kev txiav txim los ntawm kev txheeb xyuas, xws li kev sib xyaw tsis yog txais tos, tab sis tsis muaj kev xaiv. Txhawm rau kom tsis txhob muaj teeb meem, qhov koob tshuaj ntawm kev raug ncua tau txo mus rau 32 mg ntawm amoxicillin rau 1 kg ntawm qhov hnyav. Cov kev kho mob tau ua tiav.

Anna, 32 xyoo lawm Ib hlis dhau los, ib tug me nyuam poob mob. Ua npaws kub siab, mob caj pas. Lub tsev kho mob tau kuaj pom muaj cov mob tonsillitis. Tus kws kho mob tau hais tias Amoxiclav raug rho tawm haujlwm yuav pab tau. Nws tau sau tseg tias cov tshuaj ntawm cov tshuaj yuav tiv thaiv sai nrog kev kis tus kab mob. Nws hais tias yuav siv nws li cas - noj 5 ml ntawm amoxicillin 3 zaug hauv ib hnub. Khaws cov khoom raug ncua cia rau hauv tub yees. Lawv tau zoo nyob rau hauv 3 hnub, thiab tsis muaj qhov tsis haum tshuaj.