Cov tshuaj Zanocin: cov lus qhia rau kev siv

Zanocin muaj nyob rau hauv cov ntawv hauv qab no:

• Kev daws rau Txoj kev lis ntshav (100 ml hauv lub raj mis, 1 lub raj mis hauv lub thawv ntawv thawv),
• Cov ntsiav tshuaj, pleev xim lossis cov yeeb yaj kiab-pleev xim (10 pcs. Hauv cov hlwv, 1 lub hlwv hauv pob duab los qhia).

Cov tshuaj muaj pes tsawg leeg ntawm 1 ntsiav tshuaj thiab 100 ml ntawm kev daws teeb meem suav nrog cov tshuaj nquag: ofloxacin - 200 mg.

Cov Tshuaj Hauv Tshuaj

Ofloxacin, cov tshuaj nquag siv, yog ib tus neeg ua haujlwm tawm tswv yim-spectrum antimicrobial uas yog ib feem ntawm fluoroquinolone pawg. Nws ua rau cov kab mob DNA enzyme DNA gyrase, uas yog lub luag hauj lwm rau supercoiling, thiab, raws li, hloov kev ruaj ntseg ntawm DNA ntawm cov kab mob me me (kev txav tsis taus ntawm DNA saw ua rau lawv tuag). Cov tshuaj kuj tseem muaj cov kab mob bactericidal.

Ofloxacin zoo heev tiv thaiv cov kab mob hauv qab no:

• Anaerobes: Clostridium perfringens,
• Gram-negative aerobes: Serratia marcescens, Acinetobacter calcoaceticus, Pseudomonas aeruginosa (sai los tiv thaiv), Bordetella pertussis, Providencia stuartii, Providencia rettgeri, Citrobacter koseri, Citrobacter freundii, Proteus vulgareroeroberioerobacterio Klebsiella pneumoniae, Klebsiella oxytoca, Haemophilus influenzae, Haemophilus ducreyi, Morganella morganii, Moraxella catarrhalis,
• aerobes zoo-mob: Streptococcus pyogenes, Kab mob Streptococcus pneumoniae (cwj mem mob leeg qhov muag), Staphylococcus saprophyticus, Staphylococcus epidermidis (hom mob methicillin-rhiab), Staphylococcus aureus (kab mob methicillin-rhiab),
• lwm tus: Ureaplasma urealyticum, Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Legionella pneumophila, Gardnerella vaginalis.

Feem ntau, ofloxacin tsis kam ua yog pom los ntawm Treponema pallidum, Nocardia asteroides, feem ntau ntawm cov kab mob Streptococcus spp., Enterococcus spp., Kab mob Anaerobic (suav nrog Clostridium difficile, Bacteroides spp., Fusobacterium spp., Peptococcus spppppp. Epp.). Cov.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, ofloxacin yog nqus sai thiab yuav luag tiav (kwv yees 95%). Bioavailability muaj peev xwm ntau dua 96%, thiab qib ntawm kev khi rau cov ntshav protein yog 25%. Thaum muab tshuaj, qhov siab tshaj plaws ntawm cov tshuaj yog ua tiav tom qab 1-2 teev thiab tom qab kev tswj hwm hauv koob tshuaj 200 mg, 400 mg thiab 600 mg yog sib npaug ntawm 2.5 μg / ml, 5 μg / ml thiab 6.9 μg / ml, feem.

Noj noj tuaj yeem txo tus nqi nqus dej ntawm kev ua kom nquag plias ntawm Zanocin, tab sis tsis tshua muaj kev cuam tshuam nws cov bioavailability.

Tom qab kev tso dej ib leeg ntawm 200 mg ofloxacin, uas kav ntev li 60 feeb, qhov nruab nrab ntshav siab tshaj plaws ntawm cov tshuaj yog 2.7 μg / ml. 12 teev tom qab kev tswj hwm, nws tus nqi poob rau 0.3 μg / ml. Kev sib xyaw ua kom sib luag yog ua tiav tau tom qab kev qhia tsawg kawg 4 koob tshuaj ntawm Zanocin. Qhov nruab nrab ntawm qhov nruab nrab thiab qhov siab tshaj qhov sib npaug yog ua tiav tom qab kev saib xyuas ntawm ofloxacin txhua 12 teev rau 7 hnub thiab yog 0.5 thiab 2.9 μg / ml, feem.

Cov pom tseeb ntim ntawm faib tau mus txog 100 litres. Ofloxacin muaj kev faib tawm zoo rau cov plab hnyuv siab raum thiab cov nqaij hauv lub cev, nkag mus rau lub zais ntawm lub qog ua kua, cov kab mob (alveolar macrophages, leukocytes), kua tsib, qaub ncaug, zis, tawv nqaij, ua pa, pob txha, nqaij mos, plab thiab plab hnyuv plab. Cov tshuaj yooj yim dhau ntawm cov ntshav-hlwb thiab placental teeb meem, yog tawm hauv niam cov kua mis thiab txiav txim siab nyob rau hauv cov kua hlwb cerebrospinal (14-60% ntawm qhov muab tshuaj).

Ofloxacin metabolism yog nqa tawm hauv lub siab (nce txog 5% ntawm cov tshuaj undergoes biotransformation), thiab cov metabolites tseem ceeb yog demethylofloxacin thiab ofloxacin-N-oxide. Qhov kev tshem tawm ib nrab-lub neej nws txawv ntawm 4,5 rau 7 teev thiab tsis nyob ntawm ib koob. Cov tshuaj sib xyaw ua ke nyob hauv cov zis - txog 75-90% tsis pauv, li ntawm 4% ofloxacin nws raug tso tawm hauv cov kua tsib. Kev tshem tawm ntxiv tsis pub tshaj 20%. Tom qab txhaj ib zaug hauv cov tshuaj hauv 200 mg, ofloxacin yog txiav txim siab nyob rau hauv cov zis li 20-24 teev.

Hauv cov neeg mob uas muaj mob rau daim siab lossis mob raum tsis ua haujlwm, tus nqi ntawm ofloxacin tshem tawm tuaj yeem qeeb. Cumulation ntawm yam khoom hauv lub cev yog tsis tuaj. Thaum lub sij hawm ua tus txheej txheem hemodialysis, txog li 10-30% ntawm cov tshuaj nquag Zanocin raug cais tawm.

Kev ntsuas rau siv

• Cov kab mob: mob txeeb zig, mob caj dab (nrog rau mob gonorrhea, mob chlamydia), ENT kabmob, mob ntsws, kabmob ntawm lub zeem muag, cov nqaij mos thiab tawv nqaij, lub plab zom mov,
• Endocarditis
• Tuberculosis (ua ib feem ntawm txoj kev kho mob sib txuas ua ib txoj kab tshuaj thib ob),
• Bacteremia.

Cov lus qhia rau kev siv Zanocin: txoj kev thiab ntau npaum li cas

Cov koob tshuaj Zanocin yog xaiv ib tus zuj zus.

Cov tshuaj hauv daim ntawv ntawm cov ntsiav tshuaj yog noj ntawm qhov ncauj. Daim ntawv thov qauv raug txiav txim siab los ntawm cov cim:

• Mob hnyuv thiab mob txeeb zig mob leeg mob: 2 zaug ib hnub, 200 mg ib,
• Cov kab mob ntawm ntau cov kev qhia: 2 zaug hauv ib hnub, 200-400 mg,
• Chlamydia: 2 zaug ib hnub, 300-400 mg rau 7-10 hnub,
• Qhov mob Prostatitis los ntawm E. coli: 2 zaug hauv ib hnub, 300 mg txhua (txog 6 lub lis piam),
• Mob hnyav tsis yooj yim sua mob gonorrhea: ib zaug 400 mg.

Zanocin nyob rau hauv daim ntawv ntawm kev daws rau kev lis ntshav yog siv cov tshuaj ua ke, kua, infusion. Cov tshuaj no feem ntau yog sau tseg:

• Cov mob txeeb zig: 2 zaug ib hnub, 200 mg ib,
• Kev mob hauv plab, kis mob ntawm cov nqaij mos, tawv nqaij, mob ua pa: 2 zaug hauv ib hnub, 200-400 mg.

Sab sij huam

Thaum kho, cov kev mob tshwm sim tom qab no tuaj yeem tsim:

• Lub hauv nruab nrab hauv lub cev: tsis muaj zog, kiv taub hau, pw tsaug zog, mob taub hau, photophobia,
• Lub plab zom mov: lub plab zom mov tsis zoo, xeev siab, raws plab, ntuav, tsis nco qab,
• Ua xua: ua npaws, tawm pob, o, khaus.

Noj ntau dhau

Cov tsos mob ntawm kev noj haus ntau dhau ntawm Zanocin yog: lub sijhawm ntev ntawm QT ntu, kiv taub hau, tsaug zog, tsis meej pem, qaug zog, tsis meej pem, ntuav. Hauv qhov no, kho lub plab zom mov thiab tsos mob kev kho mob raug pom zoo. Nrog rau kev ua kom ntev ntawm QT luv, kev soj ntsuam tas mus li ntawm ECG yog qhov tsim nyog.

Yeeb tshuaj sib cuam tshuam

Cov nyhuv ntawm kev siv Zanocin txo cov tshuaj antacids (tiv thaiv kev nqus).

Qee qhov xwm txheej, Zanocin yuav nce theophylline ntau ntau hauv ntshav.

Cov qauv ntawm Zanocin yog: Dancil, Zoflox, Tarivid, Ofloxacin, Ofloxacin Zentiva, Ofloxacin-Teva, Ofloxacin Protekh, Ofloxin, Uniflox, Phloxal.

Kev txheeb xyuas txog Zanocin

Raws li kev txheeb xyuas, Zanocin feem ntau yog kho rau cov neeg mob ua ib feem ntawm kev kho mob metroendometritis, perimetritis thiab salpingoophoritis, nrog rau lwm yam mob urological thiab gynecological. Raws li cov kws tshaj lij, txoj kev kho mob tau ua rau cov neeg ua haujlwm tau zoo thiab yog siv tau, txij li ntawm ofloxacin ua haujlwm zoo rau cov neeg ua txhaum ntawm cov kabmob no. Feem ntau ntawm cov neeg mob zam kev kho zoo, tsuas yog ib feem me me ntawm lawv tau muaj kev phiv tshuaj tsis haum xws li zawv plab, xeev siab thiab tsis nco qab, nrog rau kev tshwm sim ntawm kev yoog raws lub sijhawm kho nrog Zanocin thaum lub caij sov.

Ofloxacin muaj kev txwv tsis pub dhau lub raum, uas tso cai rau koj ua tiav cov txheej txheem o uas nrog mob urological. Twb tau 5-7 hnub tom qab pib kev kho mob, bacteriuria ploj thiab tus neeg mob txoj kev noj qab haus huv zoo dua. Cov kev mob tshwm sim muaj tsawg heev.

Zanocin tseem tseem siv tau los kho cov kab mob uas tshwm sim los ntawm Escherichia coli thiab pseudomonas. Tsis tas li, nws muaj cov nyhuv immunomodulating. Yog li, cov kws kho mob feem ntau hais txog nws rau kev kho mob AIDS thiab mob cancer, vim tias cov xwm txheej zoo li no tau pom los ntawm kev tiv thaiv kab mob tsawg.

Pharmacological thaj chaw ntawm cov tshuaj Zanocin

Cov Tshuaj Hauv Tshuaj Ofloxacin ((±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido1,2,3-de-1,4- benzoxazine-6-carboxylic acid) yog antimicrobial tus neeg sawv cev ntawm pawg fluoroquinolone. Cov kab mob cov nyhuv ntawm ofloxacin, zoo li lwm yam fluorinated quinolones, vim nws lub peev xwm los thaiv cov kab mob DNA enzyme DNA gyrase.
Cov tshuaj tiv thaiv kev tiv thaiv cov tshuaj tiv thaiv cov kab mob me me tiv rau penicillins, aminoglycosides, cephalosporins, nrog rau cov kab mob me me nrog ntau qhov kev tawm tsam.
Zanocin OD - cov tshuaj uas muaj lub sij hawm tso tawm ntev ntawm cov tshuaj nquag - ofloxacin. Cov tshuaj no yuav siv 1 zaug nyob rau ib hnub. 1 ntsiav tshuaj ntawm Zanocin OD 400 lossis 800 mg, noj ib hnub ib zaug, muab cov txiaj ntsig kho zoo ib yam li kev noj 2 cov tshuaj ib txwm muaj ofloxacin 200 thiab 400 mg, ntsig txog, noj 2 zaug ib hnub.
Zanocin hauv cov ntsiav tshuaj daim ntawv ua haujlwm tawm tsam ntau yam kab mob.
Aerobic gram-cov kab mob tsis zoo: E. coli, Klebsiella spp., Salmonella spp., Proteus spp., Shigella spp., Yersinia spp., Enterobacter spp., Morganella morganii, Providencia spp., Vibrio spp., Citrobacter spp., Serratia spp. , Pseudomonas aeruginosa, P. cepacia, Neisseria gonorrhoeae, N. meningitidis, Haemophilus influenzae, H. ducreyi, Acinetobacter spp., Moraxella catarrhalis, Gardnerella vaginalis, Pasteurella multocida, Helicobacter pyl. Hom sib txawv ntawm cov tshuaj muaj cov leeg ntshav. Brucella melitensis.
Aerobic gram-cov kab mob zoo: staphylococci, suav nrog rau penicillinase ua cov leeg lim, thiab methicillin-resistant hom, streptococci (tshwj xeeb Kab mob ntsws dej liab), Listeria monocytogenes, Corynebacterium spp.
Ofloxacin nquag ua haujlwm ntau dua ciprofloxacin hauv kev sib raug zoo Tus mob chlamydia trachomatisCov. Kuj tseem nquag tawm tsam Mycobacterium leprae thiab Mycobacterium tuberculosis thiab qee hom MycobacteriumCov. Muaj cov ntaub ntawv hais txog kev cuam tshuam ntawm ofloxacin thiab rifabutin cuam tshuam nrog M. leprae.
Treponema pallidum, cov kab mob loj, hu ua fungi thiab protozoa yog qhov tsis haum rau ofloxacin.
Cov Tshuaj Pharmacokinetics Cov tshuaj yog sai thiab yuav luag txhua yam nyob rau hauv cov hnyuv. Qhov tsis txaus ntseeg yooj yim ntawm ofloxacin yog 96% tom qab kev tswj hwm qhov ncauj. Qhov siab nyob hauv cov ntshav plasma ncav cuag 3-4 μg / ml 1-2 teev tom qab muab tshuaj rau ntawm 400 mg. Noj tsis txhob txo qhov nqus ntawm ofloxacin, tab sis qee zaum yuav ua rau qeeb tus nqi ntawm qhov nqus. Ib nrab-lub neej ntawm cov tshuaj yog 5-8 teev. Vim hais tias ofloxacin feem ntau yog ua rau lub raum, nws cov khw muag tshuaj muaj kev hloov pauv ntau hauv cov neeg mob uas tsis muaj lub raum tsis ua haujlwm (creatinine tshem tawm ≤50 ml / min) thiab yog li ntawd lawv xav tau kev hloov kho koob tshuaj.
Hemodialysis me ntsis txo qhov kev nkag siab ntawm ofloxacin hauv ntshav ntshav. Ofloxacin yog dav faib nyob rau hauv cov ntaub so ntswg thiab lub cev ntawm lub cev, suav nrog CSF, qhov ntim ntawm qhov faib tawm yog li ntawm 1 txog 2.5 l / kg. Kwv yees li 25% ntawm cov tshuaj khi rau cov ntshav plasma. Ofloxacin kis dhau los ntawm cov txiaj ntsig thiab mus rau hauv niam mis. Nws mus txog rau qhov feem ntau hauv cov nqaij thiab cov dej hauv lub cev, nrog rau ascites, kua tsib, qaub ncaug, zais zis zais zis, lub zais zis, lub ntsws, lub caj pas prostate, pob txha pob txha.
Ofloxacin muaj lub nplhaib pyridobenzoxazine, uas ua rau txo tus nqi metabolic ntawm niam txiv cov khoom sib txuas. Cov tshuaj feem ntau tawm hauv cov zis tsis hloov pauv, nrog 65-80% hauv 24-4 teev. Tsawg dua 5% ntawm koob tshuaj tau tawm hauv cov zis hauv daim ntawv ntawm dimethyl lossis N-oxide metabolites. 4-8% ntawm cov koob tshuaj noj tau tawm hauv cov quav. Ib qho me me ntawm ofloxacin yog tawm hauv lub bile.
Tsis muaj qhov sib txawv ntawm qhov ntim ntawm kev faib tawm ntawm cov tshuaj hauv cov neeg laus, cov tshuaj yog tawm los ntawm lub raum feem ntau hauv kev hloov pauv, txawm hais tias qhov tsawg dua. Txij li ntawm ofloxacin muaj kev zais zais feem ntau los ntawm lub raum, thiab hauv cov neeg laus cov neeg mob, lub raum tsis ua haujlwm yog qhov tseem ceeb tshaj plaws, qhov koob tshuaj tau kho rau lub raum tsis ua haujlwm, raws li kev pom zoo rau txhua tus neeg mob.
Pharmacokinetics ntawm Zanocin OD pab txhawb rau nws qhov systemic siv. Cov zaub mov tsis cuam tshuam rau qib ntawm nqus ntawm cov tshuaj. Kev ua ntev ntawm ofloxacin ntsiav tshuaj sai dua sai sai thiab muaj qhov nqus tau zoo dua piv rau ofloxacin ntsiav tshuaj noj 2 zaug hauv ib hnub. Tom qab qhov ncauj tswj hwm ntawm Zanocin OD 400 mg, qhov siab tshaj plaws ntawm ofloxacin hauv cov ntshav plasma tau mus txog tom qab 6.778 ± 3.154 teev thiab yog 1.9088 μg / ml ± 0.46588 μg / ml. AUC0–1 yog 21.9907 ± 4.60537 μg • g / ml. Tom qab qhov ncauj tswj hwm ntawm Zanocin OD ntawm koob tshuaj 800 mg, qhov siab tshaj plaws ntawm cov tshuaj hauv plasma tau mus txog tom qab 7.792 ± 3.0357 h thiab yog 5.22 ± 1.24 μg / ml. Cov theem ntawm AUC0-t yog 55.64 ± 11.72 μg • g / ml. Hauv vitro cov tshuaj khi rau cov ntshav protein ntau li ntawm 32%.
Qhov sib xyaw ua ke ntawm cov tshuaj hauv cov ntshav ntshav tau tiav tom qab kev tswj hwm 4 zaug ntawm cov tshuaj, thiab AUC kwv yees li 40% siab dua qhov ntawd tom qab siv ib zaug.
Kev tshem tawm ofloxacin tawm ntawm lub cev yog biphasic. Nrog kev rov ua dua ntawm qhov ncauj, qhov ib nrab ntawm lub neej yog yeeb tshuaj li 4-5 teev thiab 20-25 teev. Qhov ntsuas ntawm tag nrho kev tshem thiab faib cov ntim yog kwv yees zoo ib yam rau kev siv ib lossis ntau hom

Kev siv tshuaj yaj yeeb Zanocin

Zanocin: cov koob tshuaj yog nyob ntawm hom microorganism thiab mob hnyav ua mob, lub hnub nyoog, lub cev nyhav thiab lub raum kev ua haujlwm ntawm tus neeg mob. Feem ntau, chav kawm ntawm kev kho yog 7-10 hnub, kev kho yuav tsum txuas ntxiv rau 2-3 hnub tom qab tshem tawm cov tsos mob ntawm tus mob. Hauv kev kis mob hnyav thiab nyuaj, txoj kev kho tuaj yeem ntev ntev. Cov koob tshuaj ntawm cov tshuaj yog 200-400 mg / hnub hauv 2 faib ua ob zaug. Ib koob tshuaj 400 mg (2 ntsiav tshuaj) tuaj yeem noj ib zaug, zoo dua thaum sawv ntxov. Ib koob tshuaj 400 mg ib zaug yuav pom zoo rau cov muaj mob gonorrhea mob tshiab. Koob tshuaj ntawm 400 mg yog pom zoo los ntawm WHO rau kev kho mob ruas.
Kev tso dej nrog dej yog muab rau ib koob ntawm 200 mg (100 ml) ntawm tus nqi ntawm 400 mg / teev ntawm 200-400 mg 2 zaug hauv ib hnub.
Thaum tsis ua haujlwm lub raum cov koob tshuaj tau tsim coj mus rau hauv tus account qhov hnyav ntawm lub raum tsis ua haujlwm thiab creatinine tshem tawm. Qhov pom zoo thawj zaug ntawm cov tshuaj nyob rau hauv cov ntaub ntawv ntawm lub raum lub raum kev ua haujlwm yog 200 mg, tom qab ntawd cov koob tshuaj yog kho kom noj mus rau hauv tus account creatinine tshem tawm: ntawm qhov taw qhia ntawm 50-20 ml / min - hauv koob li niaj zaus 24 teev, tsawg dua 20 ml / min - 100 mg (1/2 t ablets) txhua 24 teev
Nws tsis pom zoo kom txuas ntxiv kev kho mob nrog cov tshuaj rau ntau tshaj 2 hlis.
Zanocin OD siv sijhawm 1 zaug nyob rau ib hnub thaum tib lub sijhawm noj mov. Qhov koob tshuaj txhua hnub yog teem raws li lub rooj (saib hauv qab). Cov lus pom zoo no siv rau cov neeg mob uas lub raum lub cev ua haujlwm (creatinine tshem tawm 50 ml / min). Cov ntsiav tshuaj tau nqos tag nrho.

Txhua hnub koob tshuaj mg

Exacerbation ntawm mob ntsws ntev

Uncomplicated kis kab mob ntawm daim tawv nqaij thiab subcutaneous ntaub so ntswg

Mob hnyav tsis tso zis thiab lub ncauj tsev menyuam mob gonorrhea

Tsis mob neococcal cervicitis / mob rwj vim tshwm sim los ntawm C. trachomatis

Muaj sib xyaw ntawm cov zis thiab ncauj tsev menyuam los ntawm Chlamidia trachomatis thiab / lossis Neisseria gonorrhoeae

Mob voos kab mob ntawm lub plab hu ua pelvic plab hnyuv siab raum

Kev mob cystitis tsis yooj yim tshwm sim los ntawm Escherichia coli lossis Klebsiella pneumoniae

Cystitis tsis yooj yim tshwm sim los ntawm lwm cov pathogens

1Tus neeg sawv cev ntawm tus kabmob yog tsim los pab.

Thaum tsis ua haujlwm lub raum cov koob tshuaj tau hloov kho thaum creatinine tshem tawm yog ≤50 ml / min. Tom qab cov koob tshuaj ib txwm pib, thaum thov Zanocin OD 400 mg, cov koob tshuaj raug kho raws li cov hauv qab no:

Txij nkawm cov koob tshuaj thiab zaus ntawm kev tswj hwm

Txog kev kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, mob ntsws los yog ua kom tus mob txhawm rau mob txhaws, mob ntsws ntawm cov kabmob plab hnyuv siab, nws xav kom noj Zanocin OD 400 mg txhua 24 teev. Txog tam sim no, tsis muaj ntaub ntawv ntseeg tau txog ntawm kev hloov pauv ntawm cov tshuaj pom zoo.

Txog hnub tim, muaj cov ntaub ntawv tsis txaus txog kev hloov pauv hauv cov koob tshuaj pom zoo rau cov neeg mob uas muaj creatinine tshem tawm ≤20 ml / min.

Thaum ua ntawv thov Zanocin OD 800 mg rau hnub tim, muaj cov ntaub ntawv tsis txaus txog kev hloov pauv hauv cov tshuaj pom zoo rau cov neeg mob uas muaj creatinine tshem tawm ≤50 ml / min. Yog tias tsuas yog qhov ua kom pom tseeb ntawm creatinine hauv cov ntshav ntshav paub, kev tshawb pom creatinine tuaj yeem txiav txim siab los ntawm cov mis:

72 (ntshav creatinine (ntshav / dl))

• rau cov poj niam: creatinine tshem tawm (ml / min) = 0.85 txiv neej creatinine tshem tawm.

Qhov siab ntawm creatinine nyob rau hauv cov ntshav ntshav yog saib xyuas los txiav txim lub xeev ntawm lub raum ua haujlwm.
Kev ua haujlwm siab mob siab / mob ntsws.
Ofloxacin excretion tuaj yeem txo qis hauv qhov muaj mob hepatic hnyav (kab mob siab nrog / tsis muaj ascites), yog li, qhov ntau kawg ntawm ofloxacin yuav tsum tsis pub tshaj - 400 mg ib hnub.
Ntawm cov neeg laus laus tsis tas yuav hloov kho lub koob tshuaj, tshwj tsis yog thaum muaj mob raum lossis mob rau lub cev.

Cov kws kho mob cov lus

Ib qhov tshuaj tiv thaiv qhov dav dav - Zanocin - tsim los ntawm Indian Corporation Ranbaxi Laboratories Ltd. Cov tshuaj ua hauj lwm ofloxacin (ofloxacinum) cuam tshuam rau DNA gyrase ntawm cov kab mob ntawm cov kab mob pathogenic, thaiv kev ua kom tsis muaj peev xwm rov ua lawv tus kheej.

Kab mob Cov lus no tau nkag mus rau hauv peb lub neej, kom nws nres ua rau peb ntshai. Coob tus xav tias "Kuv tau kis tus mob, haus ib ntsiav tshuaj, thiab txhua yam ploj mus," muaj coob tus xav. Qhov no yog kev xav yuam kev. Pathogenic microflora muaj peev xwm ua kom peb lub cev tawm ntawm sab hauv sab hauv, txawm tuag. Thiab qhov no yuav tshwm sim tau zoo yog tias kev ntsuas tsis tau ua raws sijhawm. Cov tshuaj tua kab mob zoo Zanocin tau tsim los ntawm pab pawg ntawm cov kws kho mob thiab kws muag tshuaj txhawm rau txhawm rau thaiv cov DNA genome ntawm cov hlwb ntawm cov kab mob pathogenic, rhuav tshem nws. Li no relieving tus neeg mob ntawm qhov ua rau ntawm nws yeej.Cov tshuaj Zanocin yuav ua rau kom nws tsis nco qab txog qhov tsis xis thiab tus neeg nyob ze ib yam li kev sib kis kab mob ntawm ntau yam keeb kwm.

Pharmacological kev txiav txim siab ntawm Zanocin

Ib qhov dav-pom kev tshuaj uas zoo tawm tsam ntau yam microbes hauv tib neeg lub cev. Nws muaj cov nyhuv ncaj qha rau cov kab mob DNA enzyme DNA gyrase, uas ua kom muaj kev ruaj khov ntawm cov kab mob DNA. Tsis tas li ntawd, cov lus qhia rau Zanocin qhia tau tias cov tshuaj no ua rau cov nyhuv bactericidal. Nquag ua tawm tsam cov kab mob me me uas tsim cov beta-lactamases, thiab ntxiv tawm tsam sai ntawm cov kab mob atypical mycobacteria.

Dosing Zanocin thiab ntau npaum tshuaj

Kev siv tshuaj Zanocin yog tso cai yog tias tus neeg mob muaj mob txeeb zig (100 mg), lub raum thiab lub cev (100-200 mg), ENT kabmob thiab ua pa, pob txha thiab pob qij txha, kis mob rau daim tawv nqaij, lub plab hauv plab, cov nqaij mos. Ntxiv rau, raws li kev txheeb xyuas, Zanocin zoo pab nrog cov kab mob enteritis thiab septic kis mob (200 mg). Cov tshuaj yog muab ob zaug ib hnub. Cov koob tshuaj tuaj yeem nce siab lossis txo qis nyob ntawm qhov mob hnyav, kev ua haujlwm ntawm lub siab thiab lub raum, thiab qhov hloov kho rau cov tshuaj ntawm cov tshuaj.

Yog tias tus neeg mob tau paub meej txog kev txo qis hauv kev tiv thaiv, rau lub hom phiaj prophylactic, nws tau raug xaj 400-600 mg rau 24 teev.

Qee zaum Zanocin raug tswj hwm poob qis ntawm 200 mg (qhov kev daws teeb meem yuav tsum yog tshiab). Lub sijhawm tiv thaiv ntawm cov txheej txheem yog 30 feeb.

Cov lus qhia rau Zanocin qhia tau tias cov tshuaj no kuj tau siv hauv lub qhov ncauj. Rau cov neeg laus, qhov tshuaj ntau tshaj txhua hnub yog 800 mg. Lub sijhawm tiv thaiv yog 1-1.5 lub lis piam.

Cov neeg mob uas lub raum tsis zoo yuav tsum tau mus tshuaj xyuas ntxiv thiab tau txais cov lus qhia tshwj xeeb. Cov neeg mob zoo li no feem ntau tau teev tseg ib nrab ntawm ib hnub ib zaug (100 mg). Hauv qee kis, 200 mg tau muab tshuaj rau thawj zaug, thiab tom qab ntawd cov chav kawm ntawm kev kho mob txuas ntxiv nrog qhov tshuaj ntawm 100 mg.

Thaum lub siab ua haujlwm siab, qhov kev noj tshuaj txhua hnub yog 100 mg (tus nqi siab tshaj plaws hauv qhov no yuav tsum tsis pub tshaj 400 mg).

Zanocin OD 400 ntsiav tshuaj tsis yog zom, ntxuav nrog ib qhov me me ntawm cov dej thaum noj mov lossis ua ntej noj mov. Qhov kev qhia dav dav ntawm kev kho yog nyob ntawm tus mob ntawm tus neeg mob, nrog rau ntawm lub sijhawm ntawm tus kab mob.

Cov Yuav Tsum Muaj

Zanocin tsis raug samfwm rau cov neeg mob uas lub siab tsis zoo rau lub Cheebtsam ntawm cov tshuaj, nrog rau kev qaug dab peg, tom qab raug mob taub hau, nrog cov txheej txheem ua mob ntawm lub hauv nruab nrab lub paj hlwb, mob hlab ntsha tawg. Nws yog nruj me ntsis txwv tsis pub siv cov tshuaj rau cov menyuam hnub nyoog qis dua 18 xyoo, cov poj niam cev xeeb tub, nrog rau lub sijhawm lactation.

Kev sib tham ntxiv yog qhov yuav tsum tau ua rau cov neeg mob uas mob hlwb txha caj qaum, mob hlab ntsha hlwb thiab cov hlab ntuag ntshav nrog.

Tsuas tshuaj thiab tswj hwm

Hauv daim foos ntawm txoj kev daws teeb meem, Zanocin raug muab tswj hwm qhov quav tshuaj. Koob tshuaj thiab cov qauv ntawm Txoj kev lis ntshav nyob ntawm hom thiab qhov chaw ntawm kev kis tus kab mob, qhov mob hnyav, lub hnub nyoog ntawm tus neeg mob, kev ua haujlwm ntawm nws lub siab thiab ob lub raum, nrog rau kev nkag siab ntawm cov kab mob me me.

Cov neeg mob uas ib txwm muaj feem ntau yog 200 mg ib zaug lossis ob zaug ib hnub. Hauv cov kab mob hnyav lossis nyuaj, muaj kev nce ntxiv txog li 400 mg ob zaug hauv ib hnub. Qhov siab tshaj plaws tau tso cai tau noj txhua hnub yog 800 mg. Lub sijhawm tiv thaiv ntawm Txoj kev lis ntshav yog 30-60 feeb. Ua ntej kev tswj hwm, Zanocin yog diluted nrog kev daws 5% dextrose. Sai li qhov tus neeg mob tus mob txhim kho, nws tau pauv mus rau qhov ncauj tswj hwm ntawm cov tshuaj hauv daim ntawv ntawm cov ntsiav tshuaj.

Sab hauv, Zanocin noj 200-400 mg ib hnub twg. Yog tias qhov tshuaj txhua hnub tsis ntau tshaj 400 mg, nws raug nquahu kom yuav nws thaum lub sijhawm, nyiam dua thaum sawv ntxov. Kev txhaj tshuaj ntau dua tau muab faib ua ob zaug. Nws yog ib qho tsim nyog yuav tau noj tshuaj ua ntej noj mov lossis thaum noj mov.

Nrog kab mob gonorrhea, raws li txoj cai, ib koob tshuaj 400 mg ofloxacin yog txaus. Nrog mob prostatitis, 300 mg ib hnub twg feem ntau yog kho.

Thaum lub plab tsis zoo lub hlwb, lub Zanocin txo qis:

• Yog tias KK yog 50-20 ml / min - 100-200 mg rau ib hnub,
• Yog tias CC nyob qis dua 20 ml / feeb - 100 mg / hnub.

Hemodialysis cov neeg mob tau sau ntawv 100 mg ib hnub ib zaug.

Nrog rau daim siab ua haujlwm thiab mob ntsws, cov koob tshuaj txhua hnub yuav tsum tsis pub tshaj 400 mg.

Lub sijhawm ntawm Zanocin txoj kev kho yog nyob ntawm kev nkag siab ntawm cov kab mob coj mus rau ofloxacin thiab tag nrho cov duab hauv chaw kho mob. Raws li txoj cai, kev kho mob kav:

• Rau kev kis mob ntawm cov tawv nqaij thiab cov pa ua pa - 10 hnub,
• Nrog kev kis tus kabmob ntawm cov kabmob hu ua pelvic plab hnyuv siab raum - 10-14 hnub,
• Nrog mob txeeb zig - 3-10 hnub,
• Nrog mob prostatitis - txog 6 lub lis piam.

Tom qab ploj ploj ntawm txhua tus tsos mob ntawm tus kab mob, noj tshuaj yog pom zoo kom tsawg kawg 2 hnub ntxiv.

Cov tshuaj ntsiav tau ntev ntev Zanocin OD feem ntau yog tshuaj:

• Nrog rau cov mob txeeb zig thiab cov kabmob sib kis - 400 mg / hnub rau 3-7 hnub, nrog cov kabmob sib kis ntau - 10 hnub,
• Nrog mob prostatitis - 400 mg ib hnub rau 6 lub lis piam,
• Rau kev kis mob ntawm cov tawv nqaij thiab cov nqaij mos, ua mob ua pa ua pa - 800 mg / hnub. rau 10 hnub.

Cov lus qhia tshwj xeeb

Tas nrho lub sijhawm kho yog tsim nyog:

• Xyuas kom lub cev dej kom txaus rau lub cev,
• Txhua zaus saib xyuas koj cov piam thaj hauv ntshav
• Zam kev tiv thaiv UV raug,
• Siv kev ceev faj thaum tsav tsheb thiab ua haujlwm muaj kev pheej hmoo ua haujlwm uas yuav tsum muaj qhov ntsuas phom sij.

Yog tias koj xav tau kev siv Zanocin mus sij hawm ntev, koj yuav tsum tswj hwm cov duab ntawm cov ntshav nruab nrog, raum thiab mob siab ua haujlwm.

Kev poob qis hauv kev ua kom muaj zog ntawm ofloxacin yog pom nrog kev siv tib lub sijhawm:

• antacids muaj cov tshuaj calcium, calcium thiab / lossis txhuas,
• Sucralfate
• npaj muaj divalent thiab trivalent cations,
• multivit vitamins, uas suav nrog zinc.

Vim li no, tsawg kawg 2-teev sib nrug yuav tsum tau pom nyob nruab nrab ntawm cov koob tshuaj no.

NSAIDs ua ke nrog oflaxacin ntau qhov kev pheej hmoo ntawm kev ua kom lub zog txhawb lub zog ntawm lub hauv nruab nrab lub paj hlwb thiab txoj kev txhim kho qaug dab peg.

Kev sib xyaw ua ke ntawm kev nqis tes ua tau sau tseg nrog kev siv Zanocin nrog aminoglycosides, cov tshuaj tua kab mob beta-lactam thiab metronidazole.

Ofloxacin qeeb qeeb tawm lub zog theophylline, uas ua rau muaj kev nce ntxiv hauv nws cov kev xav thiab kev txhim kho ntawm cov kev mob tshwm sim.

Ashof, Zoflox, Geoflox, Oflo, Oflox, Ofloxacin, Ofloxabol, Oflomak, Oflotsid, Ofloxin, Tariv, Taritsin, Tariferid.

Kev phiv tshuaj ntawm Zanocin

Raws li kev soj ntsuam tshawb fawb nrog kev siv rov qab siv ofloxacin, cov hauv qab no feem ntau pom: xeev siab (3%), mob taub hau (1%), kiv taub hau (1%), raws plab (1%), ntuav (1%), tawm pob (1%), khaus tawv nqaij (1%), khaus ntawm qhov chaw mos ntawm sab nraud rau poj niam (1%), vaginitis (1%), dysgeusia (1%).
Hauv kev sim tshuaj, cov kev mob tshwm sim feem ntau uas tshwm sim tsis hais tshuaj ncua sij hawm yog xeev siab (10%), mob taub hau (9%), dysomnia (7%), khaus ntawm sab nraud ntawm qhov chaw mos ntawm cov poj niam (6%), kiv taub hau (5 %), vaginitis (5%), raws plab (4%), ntuav (4%).
Hauv kev sim tshuaj, cov kev mob tshwm sim feem ntau uas tau tshwm sim tsis hais lub sijhawm txog sijhawm siv tshuaj thiab tau pom nyob hauv 1-3% ntawm cov neeg mob tau mob plab thiab mob plab, mob hauv siab, tsis qab los noj mov, daim di ncauj qhuav, dysgeusia, qaug zog, flatulence, cuam tshuam ntawm Lub plab zom zaws, mob plab, pharyngitis, pruritus, kub taub hau, tawm pob, ua tsis taus pa, tsaug zog, mob lub cev, tso tawm qhov paum, pom kev tsis zoo, cem quav.
Cov kev mob tshwm sim uas tau sau tseg hauv cov kev tshawb fawb hauv cov chaw kho mob tsawg dua 1% ntawm cov neeg mob, tsis hais qhov kev siv tshuaj ntev npaum li cas:
kev ua yuam cai dav dav: asthenia, chilliness, malaise, mob nyob rau hauv cov nqua, cov ntswg ntswg,
los ntawm cov hlab plawv system: raug ntes mob, hlab ntshav hlab ntshav, ntshav siab, ntshav ncig qis ntshav siab, qhov hnov ​​ntawm lub plawv dhia, vasodilation,
los ntawm lub plab zom mov: dyspepsia
los ntawm cov kaw lus genitourinary: kev hnov ​​mob ntawm qhov kub, khaus, mob thiab tawm pob hauv thaj chaw ntawm pojniam, dysmenorrhea, metrorrhagia,
los ntawm cov leeg musculoskeletal: arthralgia, myalgia,
los ntawm lub hauv nruab nrab hauv lub paj hlwb: convulsions, ntxhov siab vim, cuam tshuam ntawm kev txawj ntse, kev nyuaj siab, kev npau suav tsis meej, kev zoo siab, pom kev sib deev, sib deev, tsis nco qab, tsis meej pem, tshee tshee,
los ntawm sab ntawm cov metabolism: nqhis dej, poob,
los ntawm kev ua pa: ua tsis taus pa ntes, hnoos, mob ntsws,
kev ua xua thiab tawv nqaij ua xua: angioedema, hyperhidrosis, urticaria, tawm pob, mob vasculitis,
los ntawm cov kabmob piav thoob hlo: hnov lus, tinnitus, photophobia,
los ntawm cov kab mob urinary: mob plab, tso zis heev, tso zis cia.
Hloov pauv hauv chav ntsuas tau pom pom hauv ≥1% ntawm cov neeg mob uas tau siv rov qab siv ofloxacin. Cov kev pauv hloov no yog tshwm sim los ntawm ob qho tib si noj tshuaj thiab ua mob hauv qab:
los ntawm cov ntshav system: anemia, leukopenia, leukocytosis, neutropenia, neutrophilia, stab neutrophilia, lymphocytopenia, eosinophilia, lymphocytosis, thrombocytopenia, thrombocytosis, nce ESR,
los ntawm hepatobiliary system: nce qib ntawm alkaline phosphatase, asat, alat,
kev kuaj ntsuas: hyperglycemia, ntshav qab zib ntshav qab zib, hypercreatininemia, muaj ntau theem ntawm urea, glucosuria, proteinuria, alkalinuria, hypostenuria, hematuria, pyuria.
Kev pab cuam tom qab muag zoo
Cov kev mob tshwm sim ntxiv uas tau tshwm sim tsis hais txog kev siv sijhawm ntev npaum li cas ntawm cov tshuaj tau sau tseg los ntawm kev tshawb fawb kev lag luam ntawm quinolones, suav nrog ofloxacin.
Los ntawm cov kab mob plawv: cerebral thrombosis, mob ntsws ntsws, tachycardia, hlab ntsha hypotension / poob siab, tsaus muag, leeg hlab ntsha tachycardia xws li pirouette.
Los ntawm cov kab ke endocrine thiab metabolism: hyper-lossis hypoglycemia, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib uas siv tshuaj tua kab mob ntshav lossis tshuaj noj ntshav qab zib hauv qhov ncauj.
Los ntawm cov hnyuv: hepatonecrosis, mob daj ntseg (cholestatic lossis hepatocellular), kab mob siab, mob hnyuv perforation, mob siab tsis ua haujlwm (suav nrog rau kev mob tuag taus), mob pseudomembranous mob plab (cov tsos mob pseudomembranous mob plab tuaj yeem tshwm sim ob qho tib si thaum thiab tom qab siv tshuaj tua kab mob), los ntshav los ntawm txoj hnyuv, ua paug, mob plab plhaub ntawm lub qhov ncauj kab noj hniav, kub siab.
Los ntawm genitourinary system: poj niam qhov quav.
Los ntawm cov ntshav system: anemia (suav nrog hemolytic thiab aplastic), hemorrhage, pancytopenia, agranulocytosis, leukopenia, thim rov qab inhibition ntawm cov pob txha mob ua haujlwm, thrombocytopenia, thrombocytopenic purpura, petechiae, subcutaneous hemorrhage / bruising.
Los ntawm cov leeg musculoskeletal: tendonitis, leeg pob txha caj dab, tsis muaj zog, mob leeg pob txha tsis yooj yim.
Los ntawm sab ntawm lub hauv nruab nrab hauv lub paj hlwb: npau suav phem, tua tus kheej txoj kev xav lossis kev ua, tsis meej xeeb, puas siab puas ntsws kev xav, paranoia, phobia, ntxhov siab, ntxhov siab, kev ua nruj ua tsiv / ua yeeb ncuab, mania, lub siab xav ua kom zoo, peripheral neuropathy, ataxia, ua kom tsis muaj kev sib koom tes, muaj kev nyuaj siab yog tau myasthenia gravis thiab cov kab mob extrapyramidal, mob plab, kiv taub hau.
Los ntawm tus txheej txheem ua pa: dyspnea, bronchospasm, kev tsis haum tshuaj mob ntsws, hawb pob.
Kev ua xua thiab ua xua tawv nqaij: anaphylactic / anaphylactoid cov tshuaj tiv thaiv / poob siab, purpura, ntshiab ntshav mob, multimorphic erythema / Stevens-Johnson syndrome, erythema nodosum, exfoliative dermatitis, hyperpigmentation, mob ua paug epidermal necrolysis, mob ua paug, mob hlwb / phototoxicity tshua, vesiculobulosis.
Ntawm qhov txhia chaw: diplopia, nystagmus, plooj tsis pom kev, dysgeusia, hnov ​​tsis hnov ​​tsw, hnov ​​lus thiab tshuav nyiaj li cas, uas, raws li txoj cai, dhau tom qab txiav cov tshuaj.
Los ntawm cov kab mob urinary: anuria, polyuria, laij nyob rau hauv lub raum, lub raum tsis ua haujlwm, interstitial nephritis, hematuria.
Kev ntsuas ntsuas: lub sijhawm ntev ntawm prothrombin lub sijhawm, acidosis, hypertriglyceridemia, cov roj (cholesterol) ntau ntxiv, cov kab mob potassium, daim siab ua haujlwm, nrog rau gamma-glutamyltranspeptidase, LDH, bilirubin, albuminuria, candiduria.
Hauv kev sim tshuaj kho mob nrog kev siv dua quinolones, ophthalmic mob tau tshwm sim, suav nrog cataract thiab pinpoint opacification ntawm lub lens. Cov kev sib txuas ntawm kev noj cov tshuaj thiab cov tsos ntawm cov kev tsis zoo no tseem tsis tau tsim.
Qhov tshwm sim ntawm crystalluria thiab cylindruria tau qhia nrog kev siv lwm cov quinolones.

Tshuaj Sib Tham Zanocin

Antacids, ua tiav, cov ntawv hlau, tshuaj ntau yamCov. Quinolones ua cov chelating sib txuas nrog cov kab mob alkaline thiab cov nqa khoom ntawm cov hlau cations. Kev siv cov tshuaj quinolones ua ke nrog kev tiv thaiv antacid uas muaj cov calcium, magnesium lossis aluminium, ua tiav, sib xyaw los yog sib xyaw (hlau), multivitamin kev npaj muaj zinc, didanosine tuaj yeem txo qhov nqus ntawm quinolones, thiaj li txo qis lawv cov kev muaj zog. Cov tshuaj saum toj no tau noj 2 teev ua ntej lossis tom qab noj ofloxacin.
Caffeine Tsis muaj kev sib cuam tshuam tau tshawb pom.
CyclosporinsCov. Tsis muaj xov xwm tshaj tawm txog kev nce qib ntawm cyclosporine hauv ntshav ntshav thaum ua ke nrog quinolones. Txoj kev muaj peev xwm cuam tshuam ntawm quinolones thiab cyclosporins tseem tsis tau kawm.
Cimetidine ua rau muaj kev ua txhaum ntawm kev tshem tawm qee cov quinolones, uas yog nws tau ua rau nce ntxiv hauv ib nrab-lub neej ntawm cov tshuaj thiab AUC. Qhov sib cuam tshuam tau ntawm ofloxacin thiab cimetidine tsis tau kawm.
Cov tshuaj uas cuam tshuam los ntawm cytochrome P450 enzymesCov. Feem ntau kev npaj quinolone inhibit qhov kev ua si enzymatic ntawm cytochrome P450. Qhov no tuaj yeem ua rau ntev dua ntawm ib nrab-lub neej ntawm cov tshuaj uas metabolized los ntawm tib lub cev (cyclosporine, theophylline / methylxanthines, warfarin) thaum ua ke nrog quinolones.
NSAIDs. Kev siv cov NSAIDs thiab quinolones, suav nrog ofloxacin, tuaj yeem ua rau muaj kev pheej hmoo ntau ntxiv ntawm cov nyhuv cuam tshuam rau lub hauv nruab nrab lub paj hlwb thiab mob leeg.
ProbenecidCov. Kev siv ua ke ntawm probenecid thiab quinolones yuav cuam tshuam rau lub raum kev ua paug. Cov nyhuv ntawm probenecid ntawm ofloxacin excretion tsis tau kawm.
Theophylline. Plasma theophylline qib yuav nce ntxiv thaum uas sib xyaw nrog ofloxacin. Zoo li lwm yam quinolones, ofloxacin tuaj yeem ntev mus ntev li ib nrab-lub neej ntawm theophylline, nce ntshav ntxiv ntawm theophylline thiab muaj kev pheej hmoo ntawm phiv theophylline. Nws yog ib qho tsim nyog yuav tsum tau txiav txim siab tsis tu ncua cov theem ntawm theophylline hauv ntshav ntshav thiab kho cov koob tshuaj thaum nws raug tswj xyuas tsis tu ncua nrog ofloxacin. Cov kev mob tshwm sim (suav nrog qaug dab peg) yuav tshwm sim nrog / tsis muaj kev nce qib ntawm theophylline hauv ntshav ntshav.
Warfarin. Qee qhov quinolones tuaj yeem txhim kho qhov tshwm sim ntawm kev tswj hwm qhov ncauj ntawm warfarin lossis nws cov lus dag. Yog li ntawd, nrog kev siv ua ke ntawm quinolones thiab warfarin lossis nws cov lus dag, lub sijhawm prothrombin thiab lwm yam kev ntsuas ntawm ntshav coagulation tau soj ntsuam tas li.
Cov tshuaj tiv thaiv kab mob (insulin, glyburide / glibenclamide)Cov. Nws tau tshaj tawm txog kev hloov pauv hauv cov ntshav hauv ntshav, suav nrog hyper- thiab hypoglycemia, thaum noj quinolone tshuaj thiab tshuaj tiv thaiv kab mob, yog li glycemia yuav tsum tau soj ntsuam tas li nrog kev siv cov tshuaj ua ke saum toj no.
Cov tshuaj cuam tshuam rau raum tubular excretion (furosemide, methotrexate). Nrog rau kev tswj hwm ib txhij ntawm quinolones thiab tshuaj uas cuam tshuam rau raum tubular excretion, qhov kev ua txhaum ntawm kev nthuav tawm thiab nce ntxiv hauv theem ntawm quinolones hauv ntshav plasma yuav tshwm sim.
Ua rau ntawm kev kuaj lossis kuaj pomCov. Qee qhov quinolones, suav nrog ofloxacin, tuaj yeem muab cov txiaj ntsig tsis zoo rau kev txiav txim siab ntawm opiates hauv cov zis nrog lub qhov ncauj tswj hwm ntawm cov tshuaj tiv thaiv kab mob.
Thaum tsis muaj cov ntaub ntawv ntawm kev sib xyaw ntawm txoj kev daws teeb meem nrog lwm cov kev daws teeb meem lossis Zanocin npaj rau hauv daim ntawv ntawm txoj kev daws rau infusion, nws yog qhov yuav tsum tau siv nws cais. Cov tshuaj yeeb yaj kiab tau sib xyaw nrog isotonic sodium chloride tov, lub suab sib tov, 5% piam thaj lossis kua fructose.