Thioctic acid npaj: daim ntawv teev npe, cov npe, daim ntawv tso tawm, lub hom phiaj, cov lus qhia rau kev siv, ntsuas thiab contraindications

Hauv tsab xov xwm, peb xav txog kev npaj thioctic acid yog dab tsi.

Thioctic (lip-lipoic) acid muaj peev xwm khi dawb radicals. Nws tsim nyob rau hauv lub cev tshwm sim thaum lub oxidative decarboxylation ntawm α-keto acids. Nws koom rau hauv cov txheej txheem oxidative ntawm decarboxylation ntawm acids-keto acids thiab pyruvic acid ua ib qho enzyme ntawm mitochondrial multienzyme complexes. Los ntawm nws cov txiaj ntsig biochemical, cov tshuaj no yog ze rau cov vitamins B. Thioctic acid npaj pab ua kom cov neeg ua kom zoo li qub, cov ntshav qabzib tsawg, nce glycogen ntau hauv lub siab, txo insulin tsis kam, txhim kho daim siab ua haujlwm, thiab cuam tshuam ncaj qha rau kev tswj ntawm lipid thiab carbohydrate metabolism.

Cov Tshuaj Pharmacokinetics

Thaum noj ntawm qhov ncauj, thioctic acid yog nqus sai. Hauv 60 feeb, nce mus txog qhov siab tshaj plaws hauv lub cev. Lub bioavailability ntawm yam khoom yog 30%. Tom qab kev tso ntshav tawm ntawm cov tshuaj thioctic acid 600 mg tom qab 30 feeb, cov ntshav siab kawg tau mus txog.

Kev mob plab zom mov tshwm sim hauv daim siab los ntawm kev ua rau oxidation ntawm cov plaub hau sib txuas thiab sib txuas ua ke. Ib qho tshuaj muaj cov cuab yeej ntawm thawj zaug nkag mus rau hauv lub siab. Ib nrab-lub neej yog 30-50 feeb (dhau ntawm ob lub raum).

Daim ntawv tso tawm

Thioctic acid yog tsim nyob rau hauv ntau npaum cov tshuaj, tshwj xeeb hauv daim ntawv ntawm cov ntsiav tshuaj thiab infusion daws. Cov koob tshuaj kuj tseem muaj qhov sib txawv nyob ntawm tus qauv uas tso tawm thiab cov tshuaj ntawm cov tshuaj.

Cov lus qhia rau kev siv thioctic acid npaj tau piav qhia txhua yam hauv cov lus qhia. Lawv muab tshuaj rau ntshav qab zib thiab haus dej haus cawv polyneuropathy.

Cov Yuav Tsum Tau Ua

Daim ntawv ntawm contraindications rau cov cuab yeej no suav nrog:

• lactose tsis kam lees lossis poob,
• galactose thiab qabzib malabsorption,
• lactation, cev xeeb tub,
• hnub nyoog qis dua 18 xyoo
• siab rhiab heev rau cov Cheebtsam.

Kev tswj hwm cov tshuaj tiv thaiv yuav tsum tau ua nrog ceev faj rau cov neeg tom qab 75 xyoo.

Kev qhia rau kev siv

Thioctic acid npaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj tau noj tag nrho, 30 feeb ua ntej noj tshais, nrog dej. Qhov pom zoo koob tshuaj yog 600 mg ib hnub ib zaug. Ntsiav tshuaj tau pib tom qab chav kawm ua niam txiv ntawm 2-4 lub lis piam. Kev kho siab kawg yog tsis ntau tshaj 12 lub lis piam. Kev kho ntev dua yog ua tau raws li kws kho mob hais.

Cov mloog zoo rau kev daws teeb meem yog muab kua nrog dej maj mam nkag mus. Kev daws yuav tsum npaj kom txhij tam sim ntawd ua ntej Txoj kev lis ntshav. Cov khoom npaj tau yuav tsum muaj kev tiv thaiv los ntawm tshav ntuj, hauv qhov no nws tuaj yeem khaws cia mus txog 6 teev. Cov chav ntawm kev siv daim ntawv kho mob no yog 1-4 lub lim tiam, tom qab ntawd koj yuav tsum hloov mus rau ib lub ntsiav tshuaj.

Qhov kev npaj ntawm thioctic acid zoo dua yog nthuav tawm rau ntau.

Sab sij huam

Cov xwm txheej hauv qab no tshwm sim muaj kev phiv tshuaj thaum siv cov tshuaj no:

• ntuav, xeev siab, raws plab, mob plab, kub siab,
• kev ua xua (ua pob ua pob khaus, khaus), anaphylactic ceeb,
• ua txhaum ntawm saj
• hypoglycemia (tawm hws ntau dhau, cephalalgia, kiv taub hau, qhov muag plooj),
• thrombocytopathy, purpura, mob ntshav tawm hauv plab thiab daim tawv nqaij, hypocoagulation,
• autoimmune insulin syndrome (rau cov neeg mob ntshav qab zib),
• kub muag, cramps,
• nce kev ua si ntawm cov enzymes zom,
• mob hauv lub plawv, nrog rau cov lus qhia sai sai ntawm tus neeg muab tshuaj - ua kom lub plawv dhia,
• thrombophlebitis
• daim ua pov thawj, qhov muag plooj,
• tsis xis nyob ntawm qhov chaw txhaj tshuaj, hyperemia, o.

Nrog rau kev tswj hwm sai ntawm cov tshuaj, intracranial siab (dhau ntawm nws tus kheej) yuav nce siab, ua pa nyuaj thiab qaug zog tshwm sim.

Cov Tshuaj Uas Muaj Cov Acid

Cov tshuaj hauv qab no yog qhov feem ntau thioctic acid npaj:

• Berlition.
• "Lipothioxone."
• Oktolipen.
• "Thioctacid."
• "Neyrolipon".
• Thiogamma.
• "Xwm".
• Tielepta.
• Es Lias Lipon.

Cov tshuaj "Berlition"

Lub hauv paus tseem ceeb ntawm cov neeg sawv cev ntawm cov neeg muag tshuaj no yog alpha-lipoic acid, uas yog cov tshuaj zoo li vitamin uas ua lub luag haujlwm ntawm coenzyme hauv cov txheej txheem ntawm oxidative decarboxylation ntawm alpha-keto acids. Nws muaj cov antioxidant, hypoglycemic, cov teebmeem neurotrophic. Txo cov theem ntawm sucrose hauv cov ntshav thiab nce siab ntawm glycogen hauv daim siab, txo cov tshuaj insulin tsis kam. Tsis tas li ntawd, qhov kev tivthaiv no tswj kev rog thiab carbohydrate metabolism, tsim kho cov metabolism hauv roj.

Hauv cov neeg mob uas mob ntshav qab zib mellitus ntawm txhua yam, thioctic acid hloov qhov kev hloov pauv ntawm pyruvic acid hauv cov ntshav, txwv tsis pub cov kua qabzib ntawm cov ntshav qabzib rau cov protein thiab tsim kom muaj qhov kawg ntawm glycosation. Tsis tas li ntawd, cov kua qaub ua haujlwm txhawb kev ua haujlwm ntawm glutathione, txhim kho daim siab ua haujlwm hauv cov neeg mob uas muaj kab mob siab thiab cov kev ua haujlwm ntawm cov kab ke rau hauv cov neeg mob uas mob ntshav qab zib tsis hnov ​​tsw. Kev koom tes hauv cov rog metabolism, thioctic acid muaj peev xwm txhawb kev tsim cov phospholipids, vim li cas cov cell cell rov qab, cov metabolism hauv lub zog thiab xa cov hlab ntsha ua kom lub zog.

Cov tshuaj "Lipothioxone"

Qhov kev npaj thioctic acid yog ib hom tshuaj tiv thaiv kab mob antioxidant uas khi cov dawb radicals. Thioctic acid ua lub luag haujlwm tseem ceeb hauv metabolism mitochondrial hauv hlwb, thiab ua cov coenzyme hauv cov txheej txheem ntawm kev hloov pauv ntawm cov tshuaj nrog cov teebmeem antitoxic. Lawv tiv thaiv cov hlwb los ntawm cov radicals uas tshwm sim thaum lub sij hawm nruab nrab kev sib pauv lossis lwj ntawm cov tshuaj txawv teb chaws, thiab los ntawm kev cuam tshuam ntawm cov hlau hnyav. Tsis tas li ntawd, cov tshuaj tseem ceeb yog synergistic nrog kev hais txog cov tshuaj insulin, uas cuam tshuam nrog kev nce ntxiv hauv kev siv cov piam thaj. Hauv cov ntshav qab zib, thioctic acid txhawb kev hloov pauv hauv cov ntshav ntawm pyruvic acid.

Cov tshuaj "Oktolipen"

Qhov no yog lwm cov tshuaj raws li thioctic acid - coenzyme ntawm multienzyme mitochondrial pawg, uas koom nrog cov txheej txheem ntawm oxidative decarboxylation ntawm α-keto acids thiab pyruvic acid. Nws yog ib qho kev ua kom tsis muaj zog: tshem tawm cov dawb radicals, rov qab qib glutathione qib hauv hlwb, nce kev ua haujlwm ntawm superoxide dismutase, axonal conductivity thiab trophic neurons. Nws lub luag haujlwm tseem ceeb hauv lub zog hauv lub cev metabolism, muaj cov lipotropic zoo, thiab txhim kho daim siab ua haujlwm. Nws muaj detoxifying siv nyob rau hauv cov ntaub ntawv ntawm hnyav hlau lom thiab lwm yam intoxications.

Cov lus qhia tshwj xeeb rau kev siv tshuaj kho mob

Thaum kho nrog cov tshuaj raws li thioctic acid, ib qho yuav tsum tsis txhob haus cawv. Cov neeg mob ntshav qab zib yuav tsum muaj kev soj ntsuam cov ntshav qab zib kom tsis tu ncua, tshwj xeeb tshaj yog thawj lub sijhawm pib siv cov tshuaj tshwj xeeb. Txhawm rau kom zam dhau kev txhim kho hypoglycemia, kev kho tshuaj ntawm cov tshuaj insulin lossis tshuaj ntshav hauv qhov ncauj yuav tsum tsim nyog. Yog tias cov tsos mob ntawm tus mob hypoglycemia tshwm sim, kev siv thioctic acid yuav tsum nres tam sim ntawd. Nws kuj tseem xav tau thaum muaj kev txhim kho ntawm kev tiv thaiv kev tsis haum lub cev, piv txwv li, tawv nqaij khaus thiab malaise.

Kev siv cov tshuaj thaum cev xeeb tub, lactation thiab hauv menyuam yaus

Raws li cov lus piav qhia rau kev siv cov tshuaj muaj thioctic acid, cov tshuaj no yog sib kis thaum cev xeeb tub thiab lactation. Lub sijhawm teem ntawm cov nyiaj no hauv menyuam yaus kuj tseem tsis pom muaj dab tsi.

Yeeb tshuaj sib cuam tshuam

Nws yog ib qho tsim nyog yuav tau soj ntsuam ib lub sijhawm tsawg kawg 2 teev thaum siv thioctic acid nrog tshuaj uas muaj hlau, nrog rau cov khoom noj siv mis. Cov tshuaj tiv thaiv qhov tseem ceeb ntawm cov kua qaub no tau pom nrog cov tshuaj hauv qab no:

• cisplatin: nws cov kev ua kom tsawg dua
• glucocorticosteroids: txhim kho lawv los tiv thaiv kev cuam tshuam,
• ethanol thiab nws cov metabolites: txo qis ntawm thioctic acid, txo qis
• qhov ncauj hypoglycemic tshuaj thiab cov tshuaj insulin: lawv cov nyhuv ua tau zoo dua.

Cov tshuaj no nyob rau hauv daim ntawv ntawm concentrates rau kev npaj ntawm kev daws teeb meem yog tsis sib haum nrog kev daws teeb meem ntawm dextrose, fructose, Ringer txoj kev daws teeb meem, nrog rau cov kev daws teeb meem uas cuam tshuam nrog SH- thiab disulfide pawg.

Tus nqi ntawm cov tshuaj no

Tus nqi ntawm cov tshuaj noj nrog cov ntsiab lus ntawm thioctic acid nws txawv. Kwv yees tus nqi ntawm cov ntsiav tshuaj 30 pcs. hauv ib koob tshuaj 300 mg yog sib npaug - 290 rubles, 30 pcs. nyob rau hauv ib koob tshuaj ntawm 600 mg - 650-690 rubles.

Kev npaj zoo ntawm thioctic acid yuav pab tus kws kho mob xaiv.

Kev tshuaj xyuas txog cov tshuaj

Kev tshuaj xyuas txog cov tshuaj feem ntau zoo. Cov kws tshaj lij tau txaus siab rau lawv cov txheej txheem kho tshuaj uas yog cov tshuaj tiv thaiv mob hlwb thiab tshuaj tua kab mob thiab tiv thaiv kev siv cov neeg muaj ntshav qab zib thiab ntau cov tshuaj polyneuropathies. Ntau tus neeg mob, feem ntau cov poj niam feem ntau, noj cov tshuaj no txhawm rau kom txo tau qhov hnyav, tab sis kev xav raug faib rau qhov ua tau zoo ntawm cov tshuaj no rau qhov poob phaus. Tus nqi siab ntawm cov tshuaj no tseem tau ua haujlwm tseem.

Raws li cov neeg tau txais kev pab, cov tshuaj muaj peev xwm zam tau zoo, phiv tsis tshua pom tshwm sim, thiab ntawm lawv muaj kev fab tshuaj feem ntau pom muaj, uas feem ntau mob sib khuav xwb, cov tsos mob ploj mus rau lawv tus kheej tom qab txiav tawm cov tshuaj.

Peb tau soj ntsuam cov npe ntawm thioctic acid npaj.