Metformin 500 mg 60 ntsiav tshuaj: nqe thiab analogues, tshuaj xyuas

Metformin inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm cov hnyuv, ua kom zoo rau kev siv cov khoom qab zib ntawm cov kua nplaum, thiab tseem ua rau kev nkag siab ntawm cov ntaub so ntswg mus rau insulin.

Nws tsis cuam tshuam qhov zais cia ntawm insulin los ntawm beta hlwb ntawm tus txiav, tsis ua rau kev tsis tuaj yeem tshwm sim. Txo cov theem ntawm triglycerides thiab qis linoproteins hauv cov ntshav. Stabilizes lossis txo qhov hnyav lub cev.

Nws muaj cov nyhuv fibrinolytic vim yog kev tsuj tawm ntawm cov nqaij plasminogen activator inhibitor.

Tom qab lub qhov ncauj tswj hwm, metformin yog nqus los ntawm cov hnyuv. Bioavailability tom qab noj cov qauv tshuaj yog 50-60%. Cmax hauv cov ntshav plasma tau mus txog 2.5 teev tom qab noj.

Nws xyaum tsis khi rau cov plasma protein. Nws accumulates nyob rau hauv salivary qog, nqaij, mob siab thiab ob lub raum. Nws yog tawm tawm tsis hloov pauv los ntawm ob lub raum. T1 / 2 yog 9-12 teev.

Nrog kev ua haujlwm tsis zoo hauv lub raum, tsub zuj zuj ntawm cov tshuaj yog ua tau.

Dab tsi Metformin pab los ntawm: ntsuas

Hom 2 mob ntshav qab zib mellitus rau cov neeg laus (tshwj xeeb tshaj yog nyob rau cov neeg mob rog rog) nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj thiab kev siv lub cev, li monotherapy lossis sib xyaw nrog lwm tus neeg lub qhov ncauj hypoglycemic lossis insulin.
Hom 2 mob ntshav qab zib mellitus hauv cov menyuam yaus txij li 10 xyoo - uas ob qho tib si los kho tshuaj, thiab sib xyaw nrog insulin.

Cov Yuav Tsum Tau Ua

ketoacidosis uas yog mob ntshav qab zib, mob ntshav qab zib precoma, coma
tsis hnov mob raum muaj nuj nqi
cov kab mob siab heev uas muaj qhov tsis zoo ntawm lub raum lub raum: lub cev qhuav dej (nrog rau mob raws plab, ntuav), kub taub hau, mob hnyav kis, mob ntawm hypoxia (poob siab, sepsis, mob raum, mob ntsws bronchopulmonary)
cov kab mob hais tawm los ntawm cov mob huam thiab mob ntev tuaj yeem ua rau kev loj hlob ntawm cov nqaij mos hypoxia (lub plawv lossis ua pa tsis ua haujlwm, mob myocardial infarction)
mob hnyav thiab raug mob (thaum kho mob insulin)
ua rau lub siab ua haujlwm tsis zoo
haus cawv ntev, mob qaug dej qaug cawv
siv tsawg kawg 2 hnub ua ntej thiab hauv 2 hnub tom qab ua kev tshawb fawb radioisotope lossis xoo hluav taws xob nrog kev qhia ntawm iodine-contrast contrast medium
lactic acidosis (nrog rau keeb kwm ntawm)
ua raws cov khoom noj uas tsis muaj calories ntau (tsawg dua 1000 calories / hnub)
cev xeeb tub
kev pub mis
hypersensitivity rau cov tshuaj.

Nws tsis pom zoo kom siv cov tshuaj rau cov neeg laus dua 60 xyoo uas ua haujlwm lub cev hnyav, uas cuam tshuam nrog kev pheej hmoo ntawm kev tsim mob lactic acidosis hauv lawv.

Metformin thaum cev xeeb tub thiab pub niam mis

Cov tshuaj yog contraindicated rau kev siv thaum cev xeeb tub thiab thaum pub niam mis.Thaum npaj lossis pib cev xeeb tub, Metformin Canon yuav tsum tsis ua haujlwm ntxiv thiab kev kho tshuaj insulin yuav tsum tau siv.

Tus neeg mob yuav tsum tau ceeb toom txog qhov yuav tsum tau qhia rau tus kws kho mob thaum cev xeeb tub. Leej niam thiab tus menyuam yuav tsum saib xyuas.

Kuj tsis paub meej tias metformin ua rau kua mis tawm los.

Yog tias tsim nyog, siv cov tshuaj thaum lactation, pub mis rau noj yuav tsum tsis ua mus ntxiv.

Metformin: cov lus qhia rau kev siv

Cov tshuaj tua kab mob yuav tsum tau noj ntawm qhov ncauj, noj ib ce tag nrho, tsis ntxo, thaum noj mov lossis tam sim ntawd tom qab noj mov tas, muaj dej txaus.

Txhawm rau txo cov kev phiv los ntawm txoj hnyuv hauv plab, cov koob tshuaj yuav tsum tau muab faib ua 2-3 zaug. Tom qab 10-15 hnub, thaum tsis muaj kev mob tshwm sim los ntawm txoj hnyuv plab, nce ntxiv hauv qhov koob tshuaj yog ua tau raws li cov concentration ntawm cov piam thaj hauv cov ntshav.

Kev noj tshuaj qeeb yuav pab txhim kho lub plab zom mov ntawm cov tshuaj.Txoj kev saib xyuas txhua hnub yog 1500-2000 mg. Qhov siab rau ib hnub ntau yog 3000 mg, faib ua 3 koob.

Thaum npaj kev hloov pauv los ntawm kev noj lwm qhov ncauj hypoglycemic tus neeg sawv cev rau Metformin, koj yuav tsum tsum tsis txhob noj lwm tus neeg sawv cev hypoglycemic thiab pib noj Metformin Canon hauv kev noj tshuaj saum toj no.

Kev sib xyaw ua ke nrog cov tshuaj insulin

Qhov pom zoo thawj zaug ntawm cov tshuaj yog Metformin 500 mg thiab 850 mg - 1 ntsiav tshuaj 2-3 zaug ib hnub, Metformin 1000 mg - 1 ntsiav tshuaj 1 zaug hauv ib hnub, thaum koob tshuaj insulin raug xaiv raws li cov piam thaj hauv ntshav.

Cov menyuam yaus hnub nyoog dhau 10 xyoo

Metformin Canon yog siv rau hauv kev kho mob thiab tshuaj sib xyaw nrog kev siv tshuaj insulin Cov tshuaj pom zoo thaum pib ntawm Metformin yog 500 mg ib hnub ib hnub thaum yav tsaus ntuj nrog pluas noj mov. Tom qab 10-15 hnub, cov koob tshuaj yuav tsum tau kho raws li cov ntsiab lus ntawm cov piam thaj hauv cov ntshav. Cov koob tshuaj saib xyuas yog 1000-1500 mg / hnub hauv 2-3 koob.

Qhov siab tshaj plaws txhua hnub yog 2000 mg hauv 3 koob tshuaj sib cais. Cov neeg laus cov neeg mob Vim tias yuav txo tau kev ua haujlwm ntawm lub raum, qhov tshuaj ntawm Metformin yuav tsum raug xaiv nyob rau hauv kev soj ntsuam tas li ntawm cov raum muaj nuj nqi (kev saib xyuas cov ntshav creatinine concentration tsawg kawg 2-4 zaug hauv ib xyoos).

Lub sijhawm tiv thaiv yog txiav txim los ntawm tus kws kho mob.

Kev tsis haus yeeb tshuaj yam tsis muaj kev qhia los ntawm koj tus kws kho mob tsis pom zoo.

Sab sij huam

Los ntawm lub plab zom mov: xeev siab, ntuav, nws yog xim hlau hauv lub qhov ncauj, tsis muaj qab los noj mov, raws plab, plhaw, mob plab. Cov tsos mob no tshwj xeeb tshaj yog thaum pib kho thiab feem ntau yuav ploj mus ntawm lawv tus kheej. Cov tsos mob no tuaj yeem txo qis lub sijhawm ntawm anthocides, derivatives ntawm atropine lossis antispasmodics.

Los ntawm ib sab ntawm cov metabolism: hauv qee qhov tsis tshua muaj tshwm sim - cov kab mob lactic acidosis (yuav tsum muaj kev kho tsis zoo) nrog kev kho mob mus ntev - hypovitaminosis B12 (malabsorption).

Los ntawm cov kabmob hemopoietic: qee kis - megaloblastic anemia.

Los ntawm cov kab ke endocrine: hypoglycemia.

Kev ua xua rau: xoo pob khaus.

Cov lus qhia tshwj xeeb

Thaum kho, nws yog qhov yuav tsum tau saib xyuas lub raum ua haujlwm. Tsawg kawg 2 zaug hauv ib xyoos, nrog rau qhov pom ntawm myalgia, lub lactate cov ntsiab lus hauv cov ntshav yuav tsum txiav txim siab.

Ntxiv rau, ib zaug txhua 6 lub hlis nws yog qhov tsim nyog los tswj theem ntawm creatinine hauv cov ntshav cov ntshav (tshwj xeeb tshaj yog nyob rau hauv cov neeg mob ntawm lub hnub nyoog qib siab).

Tshuaj Metformin yuav tsum tsis txhob raug tshuaj yog tias qib creatinine hauv cov ntshav siab tshaj 135 μmol / L hauv cov txiv neej thiab 110 μmol / L hauv cov poj niam.

Tej zaum kev siv cov tshuaj Metformin txuam nrog sulfonylurea derivatives. Hauv qhov no, tshwj xeeb tshaj yog saib xyuas cov ntshav ntshav qab zib kom tsim nyog.

48 teev ua ntej thiab nyob hauv 48 teev tom qab radiopaque (urography, iv angiography), koj yuav tsum tsis txhob noj Metformin.

Yog tias tus neeg mob tau mob bronchopulmonary los yog tus kab mob sib kis ntawm cov kab mob genitourinary, cov kws kho mob uas koom nrog yuav tsum qhia tam sim.

Thaum kho, koj yuav tsum caiv tsis txhob haus cawv thiab tshuaj muaj ethanol. Cov.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Kev siv cov tshuaj rau hauv monotherapy tsis cuam tshuam rau lub peev xwm tsav tsheb thiab ua haujlwm nrog cov txheej txheem.

Thaum Metformin koom ua ke nrog lwm cov kab mob hypoglycemic (sulfonylurea derivatives, insulin), cov kev mob ntshav qab zib tsawg tuaj yeem txhim kho qhov uas lub peev xwm tsav tsheb thiab koom nrog lwm cov kev phom sij uas xav tau kev nce siab ntxiv thiab cov teeb meem psychomotor sai sai yog qhov tsis hnov lus.

Concomitance nrog lwm cov tshuaj

Contraindicated combinations Cov kev tshawb fawb radiological siv cov tshuaj iodine-radiopaque tuaj yeem ua rau kev loj hlob ntawm cov kab mob lactic acidosis hauv cov neeg mob ntshav qab zib mellitus tawm tsam keeb kwm ntawm kev ua haujlwm lub raum tsis ua haujlwm.

Kev siv cov metformin yuav tsum tau tsum tsis txhob txuas ntxiv 48 teev ua ntej thiab tsis rov ua dua tshiab dua 48 teev tom qab kev xoo hluav taws xob los ntawm kev siv tshuaj radiopaque.

Pom zoo kev sib xyaw Nrog rau kev siv tib lub sijhawm ntawm metformin nrog cawv thiab cawv muaj cov tshuaj, thaum haus dej cawv ua kom qaug cawv, thaum yoo mov los yog ua raws li cov zaub mov tsis zoo, nrog rau lub siab tsis ua hauj lwm, kev pheej hmoo ntawm lactic acidosis nce ntxiv.

Kev sib xyaw ua ke xav tau kev saib xyuas tshwj xeeb Nrog rau kev siv tib lub sijhawm ntawm metformin nrog danazol, cov nyhuv hyperglycemic yuav pib loj tuaj. Yog tias kev kho mob nrog danazol yog qhov tsim nyog thiab tom qab txiav nws, kev kho cov tshuaj metformin yuav tsum ua raws li kev tswj xyuas ntshav qabzib.

Chlorpromazine hauv kev txhaj tshuaj ntau (100 mg / hnub) txo cov tshuaj insulin tso tawm thiab ua rau cov ntshav qabzib ntau hauv cov ntshav. Nrog rau kev siv ua ke nrog cov tshuaj tiv thaiv kab mob thiab tom qab txiav tawm kev tswj hwm, kev kho tshuaj metformin yuav tsum ua raws li kev tswj xyuas ntshav qabzib.

Glucocorticosteroids (GCS) nrog rau kev siv niam txiv thiab kev siv tshuaj txo qis ua kom muaj qabzib thiab nce qhov nce siab ntawm cov piam thaj hauv cov ntshav, nyob rau qee qhov ua rau ketosis. Yog tias koj xav siv cov tshuaj sib xyaw ua ke no thiab tom qab txiav tawm kev tswj hwm ntawm corticosteroids, kev kho tshuaj metformin yog yuav tsum tau txhaj tshuaj tswj ntshav qabzib.

Nrog rau kev siv "voj" diuretics thiab metformin, muaj kev pheej hmoo ntawm cov kab mob lactic acid vim yog qhov ua tau tshwm sim ntawm lub raum tsis ua haujlwm.

Hauv qhov no, cov concentration ntawm cov piam thaj hauv cov ntshav yuav tsum tau saib xyuas thiab, yog tias tsim nyog, yuav tsum siv cov insulin. Yog tias tsim nyog, cov koob tshuaj metformin yuav tsum tau hloov kho. Nrog tib lub sijhawm siv cov metformin nrog sulfonylurea derivatives, insulin, acarbose thiab salicylates, qhov nce ntawm hypoglycemic effect yog tau.

Nifedipine nce ntxiv rau qhov nqus thiab Cmax ntawm metformin, uas yuav tsum tau ua rau suav daws thaum siv ib txhij.

“Loopback” diuretics thiab cov tshuaj uas tsis yog tshuaj steroidal (NSAIDs) ua rau muaj kev pheej hmoo ntawm txo qis raum ua haujlwm. Hauv qhov no, yuav tsum tau saib xyuas thaum siv metformin.

Noj ntau dhau

Cov tsos mob: nrog kev siv cov tshuaj metformin ntawm ib koob ntawm 85 g, tsis pom kev mob ntshav qab zib tsawg, txawm li cas los xij, kev txhim kho ntawm cov kab mob lactic acidosis tau sau tseg.

Cov tsos mob thaum ntxov ntawm tus kab mob lactic acid yog xeev siab, ntuav, raws plab, qhov kub tsawg hauv lub cev, mob plab, mob leeg nqaij, yav tom ntej yuav muaj kev ua pa ntau ntxiv, kiv taub hau, tsis hnov qab thiab txhim kho tsis nco qab.

Kev Kho Mob: Yog tias pom tias lactic acidosis, kev kho mob nrog rau cov tshuaj yuav tsum tau nres tam sim ntawd, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob ceev thiab, tau txiav txim siab qhov hnoos ntawm lactate, kev kuaj mob yuav tsum qhia meej. Qhov ua tau zoo tshaj plaws los tshem tawm lactate thiab metformin tawm ntawm lub cev yog hemodialysis. Cov kev mob tshwm sim kuj yog nqa tawm.

Kev ntsuas thiab tus nqi

Ntawm cov neeg txawv teb chaws thiab Lav Xias analogues, Metformin tau paub qhov txawv:

Metformin Richter. Cov chaw tsim khoom: Gideon Richter (Hungary). Tus nqi hauv khw muag tshuaj yog los ntawm 180 rubles.
Glucophage ntev. Cov tsim tawm: Merck Sante (Norway). Tus nqi hauv khw muag tshuaj yog los ntawm 285 rubles. Gliformin. Chaw tsim tshuaj paus: Akrikhin (Russia). Tus nqi hauv khw muag tshuaj yog los ntawm 186 rubles.

Siofor 1000. Tus tsim khoom tawm: Berlin-Chemie / Menarini (Lub Tebchaws Yelemees). Tus nqi hauv khw muag tshuaj yog los ntawm 436 rubles.

Metfogamma 850. Chaw tsim tshuaj paus: Werwag Pharma (Lub teb chaws Yelemees). Tus nqi hauv khw muag tshuaj yog los ntawm 346 rubles.

Peb tau pom cov lus txheeb xyuas txog Metformin hauv Is Taws Nem:

Tsis muaj 500 mg, Kuv yuav 1000. Qhov kev nqis siab ntawm lub ntsiav tshuaj yooj yim heev, nws tuaj yeem tawg ua 2 halves, tshwj xeeb tshaj yog vim cov ntsiav tshuaj yog oblong zoo.

Hauv qab no koj tuaj yeem tso koj kev tshuaj xyuas! Metformin puas pab daws tau tus mob?

Metformin 500 mg 60 ntsiav tshuaj: nqe thiab analogues, tshuaj xyuas

Thaum siv cov tshuaj Metformin 500, nws yuav tsum nco ntsoov tias nws tuaj yeem ua rau ntau cov kev mob tshwm sim hauv lub cev. Metformin yog tsim los ntawm cov chaw muag tshuaj hauv cov qauv ntawm cov ntsiav tshuaj coated nrog zaj duab xis tshwj xeeb lub tsho tiv no.

Ib ntsiav tshuaj Metformin muaj 500 mg ntawm lub nquag sib xyaw Metformin hauv nws cov tshuaj lom neeg. Cov tshuaj sib xyaw ua ke nyob hauv cov tshuaj sib xyaw ua ke yog nyob rau hauv daim ntawv ntawm hydrochloride.

Ntxiv nrog rau lub ntsiab nquag sib xyaw, cov tshuaj muaj pes tsawg leeg suav nrog kev sib txuas ntxiv uas ua cov haujlwm pabcuam.

Ntu ntu ntawm Metformin ntsiav tshuaj yog:

microcrystalline cellulose,
hla kev,
lim dej
polyvinylpyrrolidone,
magnesium stearate.

Cov nquag nquag ua ke, metformin hydrochloride, yog ib qho loj loj. Qhov kev nqis tes ntawm qhov kev sib txuas no yog raws li kev muaj peev xwm inhibit gluconeogenesis cov txheej txheem nqa tawm hauv cov kab mob siab.

Cov tshuaj pab txo qis ntawm kev nqus ntawm cov piam thaj los ntawm lumen ntawm lub plab zom mov thiab txhim kho kev nqus ntawm cov piam thaj los ntawm ntshav ntshav los ntawm cov ntshav ntawm cov hlab ntsha ntawm lub cev.

Qhov kev txiav txim ntawm cov tshuaj yog tswj los txhim kho qhov rhiab ntawm insulin-nyob rau hauv cov nqaij mos ua kom lub cev tiv thaiv kab mob rau cov tshuaj insulin. Cov tshuaj tsis tuaj yeem cuam tshuam rau cov txheej txheem uas ua kom paub meej txog cov tshuaj insulin hauv cov hlwb ntawm cov hlab ntsha ntawm lub cev thiab tsis ua rau pom qhov tshwm sim ntawm cov cim ntawm hypoglycemia hauv lub cev.

Cov tshuaj yuav pab ua kom nres ntawm cov tsos mob hyperinsulinemia. Txoj tom kawg yog qhov tseem ceeb tshaj plaws uas ua rau kom nce hauv lub cev qhov hnyav thiab qhov kev vam meej ntawm cov kev mob uas cuam tshuam nrog kev ua haujlwm ntawm cov vascular system hauv ntshav qab zib. Kev noj tshuaj yog qhov ua rau lub cev ruaj khov thiab ua rau lub cev hnyav dua.

Kev siv tshuaj kho mob txo cov ntshav plasma concentration ntawm triglycerides thiab qis linoproteins ntshav ntau ntxiv.

Kev noj cov tshuaj ua rau muaj kev txo qis hauv kev siv ntawm cov txheej txheem ua kom muaj roj ntau thiab cov kev cuam tshuam ntawm cov txheej txheem ntawm cov rog ua kom muaj zog. Tsis tas li ntawd, cov nyhuv fibrinolytic ntawm cov tshuaj nquag nquag ntawm lub cev tau tshaj tawm, PAI-1 thiab t-PA raug tiv thaiv.

Cov ntsiav tshuaj pab txhawb rau kev ncua ntawm kev txhim kho ntawm kev loj hlob ntawm cov leeg nqaij ntawm cov hlab ntsa.

Qhov tshwm sim muaj txiaj ntsig zoo ntawm kev noj tshuaj rau qhov xwm txheej feem ntau ntawm lub plawv thiab leeg ntshav tau tso tawm, uas tiv thaiv kev mob ntshav qab zib mob ntsws.

Kev siv tshuaj

Metformin ntsiav tshuaj noj ntawm qhov ncauj.

Thaum noj tshuaj, nws raug nquahu kom cov ntsiav tshuaj nqos tag nrho yam tsis muaj kev cheem.

Cov tshuaj yuav tsum tau siv thaum noj mov lossis siv tam sim ntawd. Siv cov ntsiav tshuaj nrog qhov ntim dej txaus.

Qhov tseem ceeb qhia tau rau kev siv tshuaj yog kev muaj ntshav qab zib hom 2 hauv tus neeg mob.

Cov lus qhia rau kev siv qhia tau tias cov tshuaj tuaj yeem siv hauv cov txheej txheem ntawm kev kho mob monotherapy lossis ua ib feem ntawm cov kev kho mob nyuaj nrog lwm tus neeg sawv cev nrog hypoglycemic lub zog lossis ua ke nrog inulin.

Cov lus qhia rau kev siv tso cai rau kev siv cov tshuaj hauv cov menyuam yaus, pib txij li 10 xyoo. Kev siv cov tshuaj tau tso cai rau menyuam yaus ob qho tib si li monotherapy, thiab kev sib xyaw nrog kev txhaj tshuaj insulin.

Qhov kev muab tshuaj thaum pib noj cov tshuaj yog 500 mg. Cov tshuaj yog pom zoo kom noj 2-3 zaug nyob rau ib hnub. Yog tias tsim nyog, nrog kev nkag mus ntxiv, cov koob tshuaj yuav raug nce ntxiv.Kev nce ntxiv rau hauv cov ntau npaum li cas yog nyob ntawm qib uas cov piam thaj hauv lub cev.

Thaum siv Metformin hauv txoj haujlwm ntawm kev saib xyuas kev noj qab haus huv, qhov kev siv ntau npaum li cas nws txawv ntawm 1,500 mus txog 2,000 mg ib hnub.

Qhov muab tshuaj rau txhua hnub yuav tsum tau muab faib ua 2-3 zaug, qhov kev siv tshuaj no zam kev tsis pom qhov tshwm sim tsis zoo ntawm lub plab hnyuv plab.

Qhov siab tshaj plaws pub siv tau raws li cov lus qhia rau kev siv yog 3000 mg rau ib hnub.

Thaum noj tshuaj, ntau npaum yuav tsum maj mam nce kom txog rau qhov pom pom qhov txiaj ntsig zoo, txoj hauv kev no yuav txhim kho qhov thev taus ntawm cov tshuaj rau lub plab zom mov.

Yog tias tus neeg mob pib noj cov tshuaj Metformin tom qab lwm yam tshuaj hypoglycemic, tom qab ntawd ua ntej siv cov Metformin lwm yam tshuaj yuav tsum nres.

Thaum siv cov tshuaj no thaum yau, kev siv tshuaj yuav tsum pib nrog kev noj tshuaj ntawm 500 mg ib hnub ib zaug.

Tom qab 10-15 hnub, kuaj ntshav rau cov piam thaj tau nqa tawm thiab, yog tias tsim nyog, qhov ntau npaum ntawm cov tshuaj noj tau hloov kho.

Qhov siab tshaj plaws qhov ntau npaum li cas cov tshuaj rau cov neeg mob hauv cov menyuam yaus yog 2000 mg. Qhov tshuaj no yuav tsum tau muab faib ua 2-3 koob tshuaj ib hnub.

Yog tias cov tshuaj siv los ntawm cov neeg laus, kev hloov kho tshuaj yuav tsum tau ua nyob rau hauv kev saib xyuas nruj ntawm cov kws kho mob koom nrog. Qhov kev thov no yog vim muaj qhov tseeb tias nyob hauv cov neeg laus, kev txhim kho ntawm ntau qib ntawm lub raum tsis ua haujlwm hauv lub cev yog qhov ua tau.

Lub sijhawm sijhawm ntawm kev siv cov tshuaj yog txiav txim siab los ntawm tus kws khomob mus koom.

Thaum lub sij hawm kho, kev kho mob yuav tsum tsis txhob muaj kev cuam tshuam yog tias tsis muaj lus qhia los ntawm tus kws kho mob.

Cov xwm txheej tsis zoo nrog Metformin kev kho

Cov lus qhia rau kev siv Metformin piav qhia txhua yam tau muaj phiv los ntawm kev siv tshuaj.

Txhua qhov kev tshwm sim uas tshwm sim thaum siv tshuaj yuav tau muab faib ua ntau pawg loj.

Cov kev mob tshwm sim tau muab faib ua feem ntau, ua tsis tau, tsis tshua muaj, tsis tshua muaj thiab tsis paub.

Tsis tshua muaj, kev mob tshwm sim xws li lactic acidosis nyob rau hauv hom 2 mob ntshav qab zib mellitus tshwm sim.

Nrog rau qhov siv ntev ntawm cov tshuaj, muaj qhov txo qis hauv qhov nqus ntawm cov vitamin B12. Yog hais tias tus neeg mob tau megaloblastic anemia, nws yog ib qhov tsim nyog yuav tsum tau coj mus rau hauv tus account qhov tseem ntawm kev txhim kho cov xwm txheej zoo li no.

Cov kev phiv loj yog cov hauv qab no:

ua txhaum ntawm saj xaav,
kev cuam tshuam ntawm txoj hnyuv,
kev zoo siab ntawm xeev siab
Cov tsos mob ntuav
qhov tshwm sim ntawm kev mob hauv plab,
tsis qab los.

Cov kev mob tshwm sim no feem ntau tshwm sim thaum thawj zaug noj tshuaj thiab feem ntau maj mam ploj mus.

Txuas ntxiv, cov kev mob tshwm sim hauv qab no tej zaum yuav tshwm sim:

Cov tawv nqaij ua xeb ua pob khaus thiab ua pob.
Kev ua haujlwm tsis zoo ntawm lub siab thiab kab mob.

Tsawg tsawg zaus, kab mob siab yuav tshwm sim hauv lub cev.

Cov kev mob tshwm sim thaum siv cov tshuaj hauv cov neeg mob yog zoo li cov kev mob tshwm sim hauv cov neeg laus.

Cov tshuaj ntawm cov tshuaj thiab nws cov nqi thiab tso tawm daim ntawv

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Cov ntsiav tshuaj tau ntim rau hauv blister pob ntawv ua los ntawm polyvinyl chloride thiab aluminium ntawv ci. Txhua pob ntawv muaj 10 ntsiav tshuaj.

Rau pob contour tau muab tso rau hauv lub thawv ntawv thawv, uas tseem muaj cov lus qhia rau kev siv. Ib daim npav xim pob ntawm cov tshuaj muaj 60 ntsiav tshuaj.

Khaws cov tshuaj rau hauv qhov chaw tiv thaiv los ntawm lub hnub ncaj qha ntawm qhov kub tsis tshaj 25 degrees Celsius. Cov tshuaj yuav tsum muab khaws cia kom deb ntawm cov menyuam yaus.

Lub txee lub neej ntawm cov khoom kho mob yog peb xyoos. Cov tshuaj yog muag hauv cov khw muag tshuaj los ntawm cov tshuaj noj.

Feem ntau ntawm kev tshuaj xyuas pom los ntawm cov neeg mob siv cov tshuaj no yog qhov zoo.

Cov tsos ntawm kev tshuaj xyuas tsis zoo yog feem ntau cuam tshuam nrog kev ua txhaum cov lus qhia rau kev siv tshuaj lossis thaum muaj kev ua txhaum ntawm cov lus pom zoo tau txais los ntawm tus kws kho mob tuaj koom.

Ntau zaus muaj cov kev txheeb xyuas ntawm cov neeg mob, uas qhia tau tias kev siv cov tshuaj txo nws lub cev hnyav.

Cov chaw tsim tshuaj loj nyob rau hauv Lavxias teb sab yog Ozone LLC.

Tus nqi ntawm cov tshuaj nyob rau hauv thaj chaw ntawm Lavxias teb sab yog nyob ntawm lub network ntawm cov khw muag tshuaj thiab thaj chaw uas cov tshuaj muag. Tus nqi nruab nrab ntawm cov tshuaj hauv Lavxias Lavxias muaj txog 105 txog 125 rubles rau ib pob.

Feem ntau cov tso tawm ntawm Metformin 500 hauv Lavxias teb chaws yog cov hauv qab no:

Bagomet,
Glycon
Glyminfor,
Glyformin
Glucophage,
Glucophage Ntev,
Methadiene
Metospanin
Metfogamma 500,
Metformin
Metformin Richter,
Metformin Teva,
Metformin hydrochloride,
Nova Met
NovoFormin,
Siofor 500,
Sofamet
Rau feeb,
Rau menyuam yaus.

Cov kab mob sib xyaw ua ke ntawm Metformin zoo sib xws hauv kev teeb tsa thiab hauv cov khoom siv nquag.

Cov ntau ntawm cov kab mob tam sim no ntawm Metformin pub rau, yog tias tsim nyog, tus kws kho mob koom nrog tau yooj yim xaiv cov tshuaj tsim nyog thiab hloov Metformin nrog lwm cov cuab yeej kho mob. Txog yuav ua li cas Metformin ua haujlwm nyob rau hauv cov ntshav qab zib, tus kws tshaj lij yuav qhia hauv cov yeeb yaj kiab hauv tsab xov xwm no.

Qhia koj qab zib lossis xaiv tus tub los ntxhais rau cov lus pom zoo Nrhiav. Nrhiav tsis pom. Tshawb pom. Nrhiav tsis pom

Tshuaj qhov ncauj hypoglycemic

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Enteric Txheej Txheej dawb, puag ncig, biconvex.

1 tabmetformin hydrochloride 500 mg

Cov muaj mob siab dua: povidone K90, pob kws nplej siab, crospovidone, magnesium stearate, talc.

Lub plhaub muaj pes tsawg leeg: methacrylic acid thiab methyl methacrylate copolymer (Eudragit L 100-55), macrogol 6000, titanium dioxide, talc.

10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, metformin yog nqus los ntawm cov hnyuv. Bioavailability tom qab noj cov qauv tshuaj yog 50-60%. Cmax hauv cov ntshav plasma tau mus txog 2.5 teev tom qab noj.

Nrog kev ua haujlwm tsis zoo hauv lub raum, tsub zuj zuj ntawm cov tshuaj yog ua tau.

- mob ntshav qab zib mellitus hom 2 yam tsis muaj ketoacidosis (tshwj xeeb tshaj yog rau cov neeg mob rog rog) nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj,

- hauv kev sib xyaw nrog cov tshuaj insulin - rau hom 2 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog nrog kev tshaj tawm ntawm kev rog, nrog rau cov kab mob insulin ua hauj lwm.

Cov koob tshuaj ntawm lub tshuaj yog teem los ntawm tus kws kho mob ib leeg zuj zus, nyob ntawm seb muaj qib ntshav qabzib hauv cov ntshav.

Thawj koob tshuaj yog 500-1000 mg / hnub (1-2 ntsiav tshuaj). Tom qab 10-15 hnub, nce ntxiv hauv koob tshuaj ntau dua yog ua tau raws cov qib ntshav qabzib.

Kev saib xyuas cov tshuaj ntawm cov tshuaj feem ntau yog 1500-2000 mg / hnub. (3-4 daim.) Qhov ntau kawg yog 3000 mg / hnub (6 ntsiav tshuaj).

Ntawm cov neeg laus laus cov koob tshuaj pom zoo txhua hnub yuav tsum tsis pub ntau tshaj 1 g (2 ntsiav tshuaj).

Metformin ntsiav tshuaj yuav tsum noj tag nrho thaum lossis noj mov tom qab noj mov nrog ib qho kua tsawg (ib khob dej). Txhawm rau kom txo cov kev mob tshwm sim los ntawm txoj hnyuv plab, qhov tshuaj txhua hnub yuav tsum tau muab faib ua 2-3 zaug.

Vim tias muaj qhov pheej hmoo ntxiv ntawm cov kab mob lactic acidosis, cov koob tshuaj yuav tsum raug txo qis yog tias muaj kev cuam tshuam loj ntawm cov metabolism hauv lub cev.

Los ntawm ib sab ntawm cov metabolism: hauv qee qhov tsawg - lactic acidosis (yuav tsum muaj kev kho mob tsis ua tiav), nrog kev kho mob mus ntev - hypovitaminosis B12 (malabsorption).

Los ntawm cov kabmob hemopoietic: qee kis - megaloblastic anemia.

Los ntawm cov kab ke endocrine: hypoglycemia.

Kev ua xua rau: xoo pob khaus.

Yeeb tshuaj sib cuam tshuam

Kev siv tib lub sijhawm sib xyaw ntawm danazol tsis pom zoo nyob rau hauv kev txiav txim kom tsis txhob muaj cov nyhuv hyperglycemic ntawm tom kawg. Yog tias kev kho mob nrog danazol yog qhov tsim nyog thiab tom qab txiav tom kawg, kev kho tshuaj metformin thiab iodine yuav tsum tswj hwm theem ntawm glycemia.

Kev sib xyaw ua ke xav tau kev saib xyuas tshwj xeeb: chlorpromazine - thaum noj ntau dua (100 mg / hnub) nce glycemia, txo qis kev tsim tawm ntawm insulin.

Hauv kev kho tshuaj tiv thaiv kev tiv thaiv thiab tom qab tso tseg kev noj cov tom kawg, koob tshuaj metformin raug kho raws li kev tswj hwm ntawm qib glycemia.

Nrog rau kev siv tib lub sijhawm nrog sulfonylurea derivatives, acarbose, insulin, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, β-blockers, nws yog qhov ua tau kom nce cov nyhuv hypoglycemic ntawm metformin.

Nrog rau kev siv tib lub sijhawm nrog GCS, qhov ncauj tawm tsam, epinephrine, sympathomimetics, glucagon, cov thyroid hormones, thiazide thiab voj diuretics, phenothiazine derivatives, nicotinic acid derivatives, txo qis hauv cov nyhuv hypoglycemic ntawm metformin yog ua tau.

Cimetidine qeeb kev tshem tawm ntawm metformin, uas ua rau muaj kev pheej hmoo ntawm lactic acidosis.

Metformin tej zaum yuav ua rau cov tshuaj anticoagulants tsis muaj zog (coumarin derivatives).

Cawv kev haus dej cawv ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob lactic acid thaum haus dej cawv ua rau qaug cawv, tshwj xeeb tshaj yog thaum muaj kev yoo mov lossis ua raws li cov zaub mov tsis zoo, nrog rau lub siab ua tsis tau.

Cev xeeb tub thiab lactation

Thaum npaj kev cev xeeb tub, nrog rau muaj xwm txheej thaum cev xeeb tub thaum noj Metformin, nws yuav tsum tso tseg thiab kev kho mob insulin yuav tsum tau kho. Txij li tsis muaj cov ntaub ntawv hais txog kev nkag mus rau hauv niam mis, cov tshuaj no yog sib kis hauv kev pub niam mis. Yog tias koj yuav tsum siv Metformin thaum pub niam mis, kev pub mis rau menyuam yuav tsum tsis ua mus ntxiv.

Cov lus thiab cov xwm txheej ntawm kev cia

Khaws rau hauv qhov chaw qhuav, tsaus ntawm qhov kub ntawm 15 ° txog 25 ° C. Khaws tsis ncav cuag ntawm cov menyuam yaus. Lub sijhawm tos tos yog 3 xyoos.

Cov lus piav qhia ntawm cov tshuaj METFORMIN yog ua raws cov lus qhia raug pom zoo rau kev siv thiab pom zoo los ntawm cov kws tsim khoom.

Pom muaj kab laum? Xaiv nws thiab nias Ctrl + Enter.

Sab Tshuaj Metformin

Los ntawm lub hauv nruab nrab hauv lub paj hlwb:

ua txhaum ntawm saj ("nws yog xim hlau" saj hauv qhov ncauj).

Los ntawm cov hnyuv:

xeev siab
ntuav
tus neeg dag
mob plab thiab tsis qab los noj mov.

Qhov tshwm sim ntawm cov kev mob tshwm sim no feem ntau yog nyob rau hauv thawj zaug lub sij hawm ntawm kev kho mob thiab feem ntau lawv kis kheej.

Txhawm rau tiv thaiv cov tsos mob, nws raug nquahu kom koj noj cov tshuaj metformin thaum lossis noj mov.

Kev noj tshuaj qeeb yuav ua rau lub plab zom mov tsis tuaj yeem.

Los ntawm hepatobiliary system:

ua txhaum ntawm lub siab ua haujlwm ntsuas,
kab mob siab.

Tom qab tshem tawm ntawm cov tshuaj metformin, muaj qhov tshwm sim tsis zoo, raws li txoj cai, yuav ploj mus.

Kev tsis haum tshuaj:

tsis tshua muaj neeg - erythema,
tawv nqaij
ua pob
urticaria.

Los ntawm sab ntawm cov metabolism:

muaj tsawg kawg - lactic acidosis (yuav tsum tsis ua txuas ntxiv ntawm cov tshuaj).

Lwm yam:

tsis tshua muaj heev - nrog rau siv ntev, hypovitaminosis B12 muaj kev txhim kho (nrog rau megaloblastic anemia) thiab folic acid (malabsorption).

Cov ntaub ntawv tshaj tawm qhia tias nyob hauv qee tus menyuam yaus hnub nyoog 10 txog 16 xyoo, cov kev mob tshwm sim zoo sib xws ntawm cov xwm txheej thiab mob hnyav rau cov neeg mob hauv cov neeg laus.

Kev ntsuas rau siv

Hom 2 mob ntshav qab zib mellitus hauv cov menyuam yaus txij li 10 xyoo - uas ob qho tib si los kho tshuaj, thiab sib xyaw nrog insulin.

Tsuas tshuaj thiab tswj hwm

Cov ntsiav tshuaj yuav tsum tau noj ntawm qhov ncauj, nqos tag nrho, tsis ntxo, thaum lossis tom qab noj mov tas, haus dej ntau.

Kev kho mob ntshav qab zib thiab kev kho kom sib xyaw nrog lwm tus neeg hauv lub qhov ncauj hypoglycemic Qhov pom zoo thawj koob yog 1000-1500 mg / hnub.

Txhawm rau txo cov kev phiv los ntawm txoj hnyuv hauv plab, cov koob tshuaj yuav tsum tau muab faib ua 2-3 zaug.

Tom qab 10-15 hnub, thaum tsis muaj kev mob tshwm sim los ntawm txoj hnyuv plab, nce ntxiv hauv qhov koob tshuaj yog ua tau raws li cov concentration ntawm cov piam thaj hauv cov ntshav.

Kev noj tshuaj qeeb me ntsis tuaj yeem pab txhim kho kev mob lub plab.

Kev saib xyuas txhua hnub koob yog 1500-2000 mg.

Qhov siab rau ib hnub ntau yog 3000 mg, faib ua 3 koob.

Thaum npaj kev hloov pauv los ntawm kev noj lwm qhov ncauj hypoglycemic tus neeg sawv cev rau Metformin Canon, koj yuav tsum tsis txhob noj lwm tus neeg sawv cev hypoglycemic thiab pib noj Metformin Canon hauv kev noj tshuaj saum toj no.

Kev sib xyaw ua ke nrog cov tshuaj insulin.

Qhov pom zoo thawj zaug ntawm cov tshuaj yog 500 mg thiab 850 mg - 1 ntsiav tshuaj 2-3 zaug hauv ib hnub, qhov tshuaj 1000 mg - 1 ntsiav tshuaj 1 zaug hauv ib hnub, koob tshuaj insulin yog xaiv raws cov ntshav qabzib.

Cov menyuam yaus hnub nyoog dhau 10 xyoo.

Metformin Canon siv nyob rau hauv kev kho mob thiab hauv kev sib xyaw ua ke nrog tshuaj insulin.

Qhov pom zoo thawj zaug ntawm cov tshuaj yog 500 mg 1 zaug hauv ib hnub nyob rau yav tsaus ntuj nrog zaub mov noj.

Tom qab 10-15 hnub, cov koob tshuaj yuav tsum tau kho raws li cov ntsiab lus ntawm cov piam thaj hauv cov ntshav.

Cov koob tshuaj saib xyuas yog 1000-1500 mg / hnub hauv 2-3 koob.

Qhov tshuaj tiv thaiv ntau tshaj plaws txhua hnub yog 2000 mg hauv 3 koob faib.

Cov neeg laus cov neeg mob.

Vim tias qhov txo qis hauv kev ua haujlwm ntawm lub raum, cov koob tshuaj yuav tsum raug xaiv los ntawm kev tshuaj xyuas cov raum ua haujlwm tsis tu ncua (saib xyuas qhov tsim nyog ntawm creatinine hauv ntshav cov ntshav tsawg kawg 2-4 zaug hauv ib xyoos).

Lub sijhawm tiv thaiv yog txiav txim los ntawm tus kws kho mob.

Kev tsis haus yeeb tshuaj yam tsis muaj kev qhia los ntawm koj tus kws kho mob tsis pom zoo.

Kev sib txuam

Kev tshawb nrhiav radiological siv iodine-muaj cov tshuaj radiopaque tuaj yeem ua rau kev txhim kho ntawm cov kab mob lactic acidosis rau cov neeg mob ntshav qab zib mellitus tawm tsam keeb kwm ntawm kev ua haujlwm lub raum tsis ua haujlwm.

Kev siv cov metformin yuav tsum tau tsum tsis txhob txuas ntxiv 48 teev ua ntej thiab tsis rov ua dua tshiab dua 48 teev tom qab kev xoo hluav taws xob los ntawm kev siv tshuaj radiopaque.

Nrog rau kev siv cov tshuaj metformin ua ke nrog kev haus cawv thiab cawv uas muaj cov tshuaj, thaum haus dej cawv ua kom qaug cawv, nrog kev tshaib plab los yog noj zaub mov muaj tsawg, nrog rau lub siab tsis ua hauj lwm, kev pheej hmoo ntawm lactic acidosis nce ntxiv.

Kev sib txuas ua ke xav tau ceev faj.

Nrog tib lub sijhawm siv cov metformin nrog danazole, kev txhim kho ntawm cov nyhuv hyperglycemic yog ua tau.

Yog tias kev kho mob nrog danazol yog qhov tsim nyog thiab tom qab txiav nws, kev kho cov tshuaj metformin yuav tsum ua raws li kev tswj xyuas ntshav qabzib.

Chlorpromazine hauv kev txhaj tshuaj ntau (100 mg / hnub) txo cov tshuaj insulin tso tawm thiab ua rau cov ntshav qabzib ntau hauv cov ntshav.

Nrog rau kev siv ua ke nrog cov tshuaj tiv thaiv kab mob thiab tom qab txiav tawm kev tswj hwm, kev kho tshuaj metformin yuav tsum ua raws li kev tswj xyuas ntshav qabzib.

Glucocorticosteroids (GCS) nrog rau kev siv niam txiv thiab kev siv tshuaj txo qis ua kom muaj qabzib thiab nce qhov nce siab ntawm cov piam thaj hauv cov ntshav, nyob rau qee qhov ua rau ketosis.

Yog tias koj xav siv cov tshuaj sib xyaw ua ke no thiab tom qab txiav tawm kev tswj hwm ntawm corticosteroids, kev kho tshuaj metformin yog yuav tsum tau txhaj tshuaj tswj ntshav qabzib.

Nrog rau kev siv "voj" diuretics thiab metformin tib lub sij hawm, muaj kev pheej hmoo ntawm cov kab mob lactic acid vim yog qhov ua tau tshwm sim ntawm kev ua haujlwm lub raum tsis ua haujlwm.

Kev siv cov beta2-adrenergic agonists nyob rau hauv hom kev txhaj tshuaj txo qhov txo cov nyhuv ntshav ntawm metformin vim qhov kev tsa ntawm beta2-adrenergic receptors.

Hauv qhov no, cov concentration ntawm cov piam thaj hauv cov ntshav yuav tsum tau saib xyuas thiab, yog tias tsim nyog, yuav tsum siv cov insulin.

Angiotensin-hloov ua enzyme inhibitors thiab lwm yam tshuaj tiv thaiv kabmob ntshav tuaj yeem txo cov ntshav qabzib.

Yog tias tsim nyog, cov koob tshuaj metformin yuav tsum tau hloov kho.

Nrog rau kev siv tib lub sijhawm ntawm metformin nrog sulfonylurea derivatives, insulin, acarbose thiab salicylates, qhov nce ntawm hypoglycemic effect yog tau.

Nifedipine nce ntxiv rau qhov nqus thiab Cmax ntawm metformin, uas yuav tsum tau ua rau suav daws thaum siv ib txhij. “Loopback” diuretics thiab cov tshuaj uas tsis yog tshuaj steroidal (NSAIDs) ua rau muaj kev pheej hmoo ntawm txo qis raum ua haujlwm.

Hauv qhov no, yuav tsum tau saib xyuas thaum siv metformin.