Hypothiazide: cov lus qhia rau kev siv

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb Kev HypothiazideCov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Hypothiazide hauv lawv cov kev coj ua. Kev thov loj yog nquag ntxiv koj cov kev txheeb xyuas txog ntawm diuretic: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Hypothiazide analogues pom muaj cov qauv txheej txheem zoo. Siv rau kev kho mob ntawm txoj kev mob ntshav ntawm txoj hlab ntshav hauv lub cev thiab cov tsos mob edematous hauv cov neeg laus, menyuam yaus, nrog rau thaum cev xeeb tub thiab lactation.

Kev Hypothiazide - tshuaj tiv thaiv kab mob (diuretic). Lub tswv yim tseem ceeb ntawm kev ua ntawm thiazide diuretics yog kom nce diuresis los ntawm inhibiting qhov rov ua kom rov qab los ntawm sodium thiab chlorine ions nyob rau ntu pib ntawm cov hlaus rov qab. Qhov no ua rau kom muaj zog ntau ntxiv ntawm sodium thiab chlorine thiab, yog li ntawd, dej. Kev tawm ntawm lwm cov electrolytes, uas yog potassium thiab magnesium, kuj nce ntxiv. Qhov siab tshaj plaws kho qhov mob, qhov diuretic / natriuretic nyhuv ntawm txhua qhov mob thiazides kwv yees li qhov qub.

Natriuresis thiab diuresis tshwm sim tsis pub dhau 2 teev thiab mus txog qib siab kawg tom qab li 4 teev.

Thiazides kuj tseem txo cov kev ua ntawm carbonic anhydrase los ntawm kev ua kom muaj qhov zam ntawm bicarbonate ions, tab sis cov nyhuv no feem ntau tsis muaj zog thiab tsis cuam tshuam rau pH ntawm cov zis.

Hydrochlorothiazide (cov tshuaj ua kom muaj zog ntawm cov tshuaj Hypothiazide) kuj tseem muaj cov khoom zoo nkauj. Thiazide diuretics tsis cuam tshuam rau cov ntshav siab.

Muaj pes tsawg leeg

Hydrochlorothiazide + kev xa tawm.

Cov Tshuaj Pharmacokinetics

Hypothiazide tsis tiav, tab sis tau yaim sai heev los ntawm lub plab zom mov. Cov nyhuv no tseem mob siab rau 6-12 teev .Txhais Hydrochlorothiazide hla lub plab qhov chaw nyob thiab tawm hauv cov kua mis. Lub hauv paus tseem ceeb ntawm kev nthuav dav yog los ntawm lub raum (lim thiab tso pa tawm) nyob rau hauv ib daim ntawv tsis hloov pauv.

Cov Khoom Qhia

• arterial hypertension (ob qho tib si rau monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj antihypertensive),
• edema syndrome ntawm ntau yam keeb kwm (mob plawv tsis ua hauj lwm, nephrotic syndrome, premenstrual nro mob syndrome, mob txha caj mob glomerulonephritis, mob raum tsis ua haujlwm, portal tawg, kho corticosteroids),
• tswj hwm ntawm polyuria, feem ntau nrog nephrogenic ntshav qab zib insipidus,
• kev tiv thaiv ntawm pob zeb tsim nyob rau hauv lub tso zis mob nyob rau hauv cov neeg mob yooj yim (txo hypercalciuria).

Tso Tawm Cov Ntawv

Ntsiav tshuaj 25 mg thiab 100 mg.

Cov lus qhia rau kev siv thiab ntau npaum li cas

Cov tshuaj yuav tsum tau xaiv ib tus zuj zus. Nrog kev saib xyuas tas li rau kev kho mob, qhov tsawg kawg yog siv tau raug teeb tsa. Cov tshuaj yuav tsum tau noj nyob rau hauv lub qhov ncauj tom qab noj mov.

Nrog rau kev mob ntshav siab, qhov pib koob tshuaj yog 25-50 mg rau ib hnub ib zaug, nyob rau hauv daim ntawv ntawm monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg sawv cev antihypertensive. Rau qee cov neeg mob, kev pib koob tshuaj 12,5 mg yog qhov txaus (ob qho tib si li monotherapy thiab hauv kev sib xyaw). Nws yog ib qho tsim nyog yuav tsum tau thov cov koob tshuaj tsawg kawg nkaus, tsis pub tshaj 100 mg ib hnub. Thaum muab cov tshuaj hypothiazide coj los siv nrog lwm cov tshuaj tiv thaiv kabmob ntshav, nws yuav tsum tau txo qhov koob tshuaj ntawm lwm cov tshuaj tiv thaiv kom tsis txhob poob siab hauv ntshav ntau.

Cov nyhuv antihypertensive tshwm sim nyob rau hauv 3-4 hnub, tab sis nws yuav siv sijhawm 3-4 lub lis piam kom ua tiav cov nyhuv siab. Tom qab qhov kawg ntawm kev kho, cov nyhuv hypotensive tseem muaj nyob rau 1 lub lis piam.

Nrog edematous syndrome ntawm ntau lub hauv paus chiv keeb, thawj qhov tshuaj yog 25-100 mg ib hnub ib zaug lossis 1 zaug hauv 2 hnub. Nyob ntawm qhov lus teb soj ntsuam, qhov tshuaj yuav raug txo kom 25-50 mg ib hnub ib zaug lossis ib zaug txhua 2 hnub. Hauv qee kis mob hnyav, thaum pib kho, yuav tsum nce qhov ntau ntxiv rau 200 mg rau ib hnub yuav tsum tau ua.

Nrog rau qhov mob ua kom tsis nco qab mob ua ntej, cov tshuaj tau raug sau ntawm koob tshuaj 25 mg rau ib hnub twg thiab tau siv txij li qhov pib mob mus txog thaum pib coj khaub ncaws.

Nrog nephrogenic ntshav qab zib insipidus, qhov kev siv tshuaj txhua hnub ntawm 50-150 mg yog qhov pom zoo (hauv ob peb koob tshuaj).

Vim tias muaj ntau cov piam thaj ntawm cov potassium thiab magnesium ions thaum kho (cov poov tshuaj poov tshuaj ntau ntau yuav yog

Pharmacological kev txiav txim

Cov nyhuv diuretic ntawm hydrochlorothiazide feem ntau yog lub luag haujlwm ncaj qha rau kev txhaws ntawm kev rov tsim ntawm Na + thiab SG hauv cov raj tub distal. Nyob hauv nws cov cawv, kev nthuav dav ntawm Na + thiab SG yog txhim kho thiab, vim qhov no, kev nthuav tawm ntawm dej, nrog rau cov poov tshuaj thiab magnesium. Cov nyhuv diuretic ntawm hydrochlorothiazide txo qhov ntim ntawm lub cev ntshav, nce kev ua haujlwm ntawm plasma renin, txhim kho kev tsis haum ntawm aldosterone, vim tias qhov kev nthuav tawm ntawm potassium thiab bicarbonate nyob rau hauv cov zis nce ntxiv thiab cov ntsiab lus ntawm cov poov tshuaj hauv ntshav dej tsawg zuj zus. Angiotensin-P tswj hwm kev ua tiav renin-aldosterone daim ntawv cog lus, yog li ntawd, kev siv ua ke ntawm angiotensin-P receptor antagonist tuaj yeem rov qab cov txheej txheem poov tshuaj excretion txuam nrog thiazide diuretic.

Cov tshuaj kuj tseem muaj lub zog thaiv tsis pub muaj zog ntawm carbonic anhydrase, mus rau ib tus neeg kawm qib nruab nrab, yog li txhim kho kev zais cia ntawm bicarbonate, thaum tsis muaj qhov hloov pauv tseem ceeb hauv cov zis pH.

Cov Tshuaj Pharmacokinetics

Hydrochlorothiazide zoo tso rau tom qab kev tswj hwm ntawm qhov ncauj, nws cov diuretic thiab natriuretic teebmeem tshwm sim tsis pub dhau 2 teev tom qab kev tswj hwm thiab mus txog lawv qhov siab kawg tom qab li 4 teev. Qhov kev txiav txim no kav rau 6-12

Zoo siab dhau los ntawm ob lub raum hauv daim ntawv tsis hloov pauv. Ib nrab-lub neej rau cov neeg mob uas lub raum tsis ua haujlwm zoo yog 6.4 teev, rau cov neeg mob uas mob raum tsis txaus - 11,5 teev, thiab rau kev mob raum tsis zoo nrog creatinine tshem tawm tsawg dua 30 ml / min. - 20.7 teev. Hydrochlorothiazide hla lub plab qhov chaw thiab yog tawm hauv cov kua mis hauv cov khoom me me.

Kev ntsuas rau siv

• Tawg ntshav (nyob rau hauv cov ntaub ntawv me - ob leeg nyob rau hauv daim ntawv ntawm monotherapy, thiab nyob rau hauv ua ke nrog lwm cov tshuaj antihypertensive).

• Edema ntawm kev mob plawv, mob rau pob txha lossis mob hlaus pob txha, mob hlwb txha ntshav txhaws, edema nrog kws kho mob, xws li corticosteroid.

• Nrog rau ntshav qab zib nephrogenic insipidus los txo cov polyuria (cov nyhuv paradoxical)

• Yuav kom txo hypercalciuria.

Cov Yuav Tsum Tau Ua

• Ua kom yauv ua rau qhov tshuaj lossis lwm yam sulfonamides

• Mob raum (rov ua kom zoo li hauv qab 30 ml / min) lossis lub siab ua haujlwm

• Kho rau kev kho mob hypokalemia lossis hypercalcemia

• Cov tsos mob hyperuricemia (gout)

Cov tshuaj tsis raug pom zoo siv rau cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Cev xeeb tub thiab lactation

Cov kev paub nrog hydrochlorothiazide thaum cev xeeb tub, tshwj xeeb tshaj yog nyob rau thawj peb hlis, muaj tsawg. Cov ntaub ntawv tau txais hauv kev kuaj tsiaj yog tsis txaus. Hydrochlorothiazide hla lub teeb meem ntawm thaj chaw. Yog tias hydrochlorothiazide siv nyob rau hauv lub sijhawm thib ob thiab thib peb, nws (vim nws txoj haujlwm pharmacological) tuaj yeem cuam tshuam lub fetoplacental perfusion thiab ua rau lub ntsej muag txhaws ntawm lub plab lossis tus menyuam yug tshiab, electrolyte tsis txaus thiab thrombocytopenia.

Hydrochlorothiazide yuav tsum tsis txhob siv thaum cev xeeb tub los kho edema, kub siab lossis preeclampsia, vim hais tias es tsis txhob muaj cov txiaj ntsig zoo rau tus kab mob, nws nce qhov kev hem thawj ntawm kev txo qis hauv plasma ntim thiab kev hem thawj ntawm cov ntshav tsis txaus rau lub tsev menyuam thiab cov txiv neej.

Hydrochlorothiazide tsis tuaj yeem siv los kho tus mob ntshav siab tseem ceeb hauv cov poj niam cev xeeb tub, tshwj tsis yog qee qhov mob thaum tsis tuaj yeem siv lwm txoj kev kho.

Hydrochlorothiazide ntsiav tshuaj yuav tsum tsis txhob siv thaum cev xeeb tub - lawv tuaj yeem siv tsuas yog hauv cov xwm txheej zoo tsim.

Hydrochlorothiazide dhau mus rau hauv niam cov kua mis; nws siv yog contraindicated thaum pub niam mis. Yog tias nws qhov kev siv dhau los, kev pub niam mis yuav tsum nres.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj yuav tsum tau xaiv ib tus zuj zus thiab yuav tsum muaj kev saib xyuas tas li. Vim tias cov piam thaj ntau ntxiv hauv cov potassium thiab magnesium thaum kho (cov poov tshuaj poov tshuaj ntau yuav poob qis dua 3.0 mmol / l), nws yuav tsum muaj cov tshuaj potassium thiab magnesium hloov. Kev saib xyuas tshwj xeeb yuav tsum tau txais nyob rau hauv cov neeg mob uas lub plawv tsis ua haujlwm, cov neeg mob uas lub siab ua tsis taus pa, lossis hauv cov neeg mob kho kho digitalis glycoside. Cov ntsiav tshuaj yuav tsum tau noj tom qab noj mov.

Raws li tus neeg sawv cev tiv thaiv kabmob (antihypertensive), qhov niaj zaus pib siv ib zaug yog 25-100 mg rau hauv ib koob, hauv kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm cov tshuaj tiv thaiv kab mob siab. Rau qee tus neeg mob, cov pib koob tshuaj 12,5 mg yog txaus, ob qho tib si hauv kev tsim tshuaj monotherapy thiab kev sib xyaw. Nws yog ib qho tsim nyog yuav tsum tau thov ib daim ntawv kho mob yam tsawg kawg nkaus tsis pub tshaj 100 mg ib hnub. Yog tias cov tshuaj tiv thaiv hypothiazide ua ke nrog lwm cov tshuaj tiv thaiv kabmob ntshav, nws yuav tsum tau txo cov tshuaj ntawm cov tshuaj ib leeg twg kom tiv thaiv kev poob siab hauv cov ntshav siab.

Cov nyhuv antihypertensive tshwm sim nyob rau hauv 3-4 hnub, txawm li cas los xij, kom ua tiav cov nyhuv siab, nws yuav siv sijhawm ntev li 3-4 lub lis piam. Tom qab kho tas, cov nyhuv hypotensive tseem mob ntev txog li ib lub lim tiam.

Hauv kev kho mob ntawm edema qhov pib noj ib txwm yog 25-100 mg ntawm cov tshuaj ib hnub ib zaug lossis ib zaug txhua ob hnub. Nyob ntawm qhov lus teb soj ntsuam, qhov tshuaj yuav tsum raug txo mus rau 25-50 mg ib hnub ib zaug lossis ib zaug txhua ob hnub. Qee qhov xwm txheej loj, yuav tau txhaj thawj koob tshuaj 200 mg ib hnub yuav tsum tau txhaj.

Hauv qhov mob ua ntej lub cev, qhov ib txwm hno tshuaj yog 25 mg rau ib hnub thiab siv txij thaum pib muaj tsos mob mus txog thaum pib coj khaub ncaws.

Nrog ntshav qab zib nephrogenic insipidus Qhov kev siv tshuaj txhua txhua hnub ntawm 50-150 mg (hauv ntau qhov tshuaj) tau pom zoo.

Cov koob tshuaj yuav tsum tsim raws li qhov hnyav ntawm tus me nyuam. Kev kuaj menyuam niaj hnub siv txhua hnub, 1-2 mg / kg ntawm lub cev qhov hnyav lossis 30-60 mg rau ib square meter ntawm lub cev, tau kho ib hnub ib zaug. Kev txhaj tshuaj rau cov menyuam hnub nyoog 6 txog 12 xyoos yog 37.5-100 mg ib hnub twg.

Noj ntau dhau

Hu rau koj tus kws kho mob lossis chav kho mob maj nrawm yog tias koj noj ntau dhau!

Qhov feem ntau pom tshwm ntawm hydrochlorothiazide lom yog mob tsis txaus kua thiab electrolytes, qhia hauv cov cim thiab cov tsos mob nram qab no:

Mob plawv: Tachycardia, hypotension, poob siab

Neuromuscular: ua kom tsis muaj zog, tsis meej pem, kiv taub hau thiab mob plab, mob plab, tsis nco qab zoo, nkees.

Pais plab hnyuv: xeev siab, ntuav, nqhis dej,

Renal: polyuria, oliguria lossis anuria.

Kev ntsuas ntsuas - hypokalemia, hyponatremia, hypochloremia, alkalosis, nce qib ntawm nitrogen hauv cov ntshav (tshwj xeeb tshaj yog nyob rau cov neeg mob raum tsis ua haujlwm).

Kev kho ntau tshaj: Cov tshuaj tiv thaiv tshwj xeeb rau intoxication

Induction ntuav, pais plab lav yuav ua tau txoj hauv kev kom tshem tawm cov tshuaj. Qhov nqus ntawm cov tshuaj muaj peev xwm txo qis los ntawm kev siv roj carbon roj carbon activated. Thaum hypotension lossis poob siab, qhov ntim ntawm cov ntshav ntshav thiab electrolytes (cov poov tshuaj, sodium, magnesium) yuav tsum them nyiaj.

Dej-electrolyte tshuav nyiaj (tshwj xeeb tshaj tawm cov poov tshuaj theem) thiab lub raum kev ua haujlwm yuav tsum tau saib xyuas kom txog thaum muaj txiaj ntsig zoo.

Kev cuam tshuam nrog lwm yam tshuaj

Nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj koj noj, txawm hais tias nws ua rau qee qhov tshwm sim.

Tej zaum muaj kev sib cuam tshuam ntawm thiazide diuretics thiab cov tshuaj hauv qab no nrog lawv siv thooj txhij.

Cawv, barbiturates, tshuaj loog thiab tshuaj tua kab mob:

Yuav txhim khu orthostatic hypotension.

Antidiabetic agents (tshuaj ntawm ncauj thiab insulin):

Kev kho mob Thiazide tuaj yeem txo cov ntshav qabzib tsawg. Koj yuav tsum tau hloov pauv ntawm koob tshuaj hypoglycemic. Metformin yuav tsum siv nrog ceev faj vim muaj kev pheej hmoo ntawm cov kab mob lactic acidosis vim muaj peev xwm ua tau lub raum tsis ua haujlwm cuam tshuam nrog hydrochlorothiazide.

Lwm cov tshuaj tiv thaiv kab mob:

Colestyramine thiab colestipol resins:

Nyob rau hauv muaj anion txauv resins, nqus ntawm hydrochlorothiazide los ntawm cov hnyuv yog qhov tsis taus. Cov koob tshuaj ib zaug ntawm colestyramine lossis colestipole resins khi hydrochlorothiazide thiab txo nws txoj kev nqus nqus hauv plab, raws li, 85% thiab 43%.

Pressor amines (piv txwv li adrenaline):

Nws muaj peev xwm tias qhov kev txiav txim ntawm cov xov xwm amines tsis muaj zog, tab sis tsis yog rau qee yam li los tiv thaiv lawv qhov kev siv.

Kev tsis ua rau cov leeg ua kom mob siab (xws li tubocurarine):

Cov nqaij ntshiv zuj zus zuj zus tuaj yeem ua rau nce siab.

Diuretics txo txoj kev ua kom lub ntsej muag ntawm lithium thiab ua rau muaj kev pheej hmoo ntau ntawm cov tshuaj lom ntawm lithium. Lawv tib txhij siv tsis pom zoo. Tshuaj kho mob rau mob gout (probenicid, sulfinpyrazone thiab allopurinol):

Yuav tsum tau txhaj cov tshuaj uricosuric ntau ntxiv, vim tias hydrochlorothiazide yuav nce qib cov uric acid ntau ntau. Kev nce ntxiv ntawm koob tshuaj probenicide lossis sulfinpyrazone yuav tsum muaj. Kev siv tib lub sijhawm thiazides tuaj yeem ua rau kom lub cev muaj kev cuam tshuam ntau ntxiv rau allopurinol.

Anticholinergics (piv txwv, atropine, biperiden):

Vim tias qhov qis qis hauv lub cev muaj zog ntawm txoj hnyuv plab thiab qhov ntsuas ntawm lub plab zom mov, lub bioavailability ntawm lub diuretic ntawm thiazide hom nce.

Cytotoxic tus neeg sawv cev (piv txwv li cyclophosphamide, methotrexate):

Thiazides tuaj yeem txo lub raum tsis ua haujlwm ntawm cov tshuaj cytotoxic thiab txhim kho lawv cov nyhuv myelosuppressive.

Thaum muab cov tshuaj salicylates siab kawg, hydrochlorothiazide tuaj yeem txhim kho lub zog ua kom muaj txiaj ntsig ntawm salicylates ntawm lub hauv nruab nrab lub paj hlwb.

Qee qhov xwm txheej, kev mob ntshav qab zib (hemolytic anemia) tau tshaj tawm nrog kev siv tib lub sij hawm ntawm hydrochlorothiazide thiab methyldopa.

Siv cov tshuaj tsis haum nrog cyclosporine tuaj yeem nce hyperuricemia thiab qhov kev pheej hmoo ntawm kev tsim muaj teeb meem xws li gout.

Hypokalemia los yog hypomagnesemia los ntawm thiazide tuaj yeem pab txhawb kev txhim kho ntawm arrhythmias kev mob siab los ntawm digitalis.

Cov tshuaj uas cuam tshuam los ntawm kev hloov pauv hauv ntshiab poov tshuaj:

Kev txiav txim siab ib zaug ntawm cov ntshav poov tshuaj ntau ntau thiab sau cov hluav taws xob electrocardiogram yog pom zoo yog tias hydrochlorothiazide siv ib txhij nrog cov tshuaj uas cuam tshuam los ntawm kev hloov pauv hauv cov poov tshuaj potassium (piv txwv li digital glycosides thiab tshuaj antiarrhythmic), nrog rau cov pirouette-hom tachycardia tshuaj (ventricular) tachycardia) (suav nrog tseem qee cov tshuaj tiv thaiv tshuaj tiv thaiv), vim tias hypokalemia yog qhov ua rau muaj kev txhim kho tachycardia xws li pirouette:

• tshuaj tsis raug ntawm cov chav kawm 1a (piv txwv li, quinidine, hydroquinidine, disopyramide),

• cov chav kawm III tshuaj tua kab mob sib kis (piv txwv li, amiodarone, sotalol, dofetilide, ibutilide),

• qee qhov tshuaj tiv thaiv kev mob (piv txwv, thioridazine, chlorpromazine, levomepromazine, trifluoperazin, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol),

• lwm yam tshuaj noj (piv txwv li, bepridil, cisapride, diphemanil, tshuaj erythromycin, halofantrine, misolastine, pentamidine, terfenadine, tshuaj vincamine).

Thiazide diuretics nce qib ntshiab calcium ntau vim qhov txo qis ua paug. Yog tias xav tau kev teem caij ntawm cov neeg sawv cev uas ntxiv cov calcium hauv cov ntsiab lus, nws yog qhov tsim nyog los tswj qib ntawm calcium hauv cov ntshav dej thiab, raws li nws, xaiv koob tshuaj calcium.

Kev sib cuam tshuam ntawm cov tshuaj thiab kev sim tshuaj: vim muaj qhov tshwm sim ntawm cov calcium metabolism, thiazides tuaj yeem cuam tshuam cov txiaj ntsig ntawm kev ntsuas parathyroid ua haujlwm

Daim ntawv thov nta

Cov chaw soj ntsuam thiab tshuaj lom yog qhov tsim nyog vim tias qhov txaus ntshai ntawm cov tsos mob hyponatremia.

Cov tshuaj tiv thaiv muaj Iodine:

Thaum lub cev qhuav dej los ntawm diuretics, txoj kev pheej hmoo ntawm lub raum tsis ua haujlwm nce siab, feem ntau yog thaum cov koob tshuaj iodine ntau ntau nyob hauv kev siv. Ua ntej siv iodine, nws yog ib qho tsim nyog los ntxiv cov kua dej hauv lub cev ntawm cov neeg mob.

Amphotericin B (kev kho mob), corticosteroids, ACTH thiab tshuaj laxatives:

Hydrochlorothiazide tuaj yeem pab txhawb cov roj ntsha tsis haum, feem ntau yog kev txhim kho hypokalemia.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv noj tshuaj: cov ntsiav tshuaj puag ncig, tiaj, nrog cov kab sib cais ntawm ib sab thiab kos "H" ntawm lwm qhov, dawb lossis yuav luag dawb (20 pcs. Hauv cov hlwv, hauv daim duab los qhia 1 lub ntsej muag thiab cov lus qhia rau kev siv Hypothiazide).

Tus nquag ua hauj lwm yog hydrochlorothiazide, nws cov ntsiab lus hauv 1 ntsiav tshuaj yog 25 lossis 100 mg.

Ntu cov khoom siv: gelatin, magnesium stearate, pob kws nplej siab, talc, lactose monohydrate.

Cov Tshuaj Hauv Tshuaj

Cov kev ua haujlwm nquag ntawm Hypothiazide yog thiazide diuretic hydrochlorothiazide, thawj qhov kev ua haujlwm ntawm kev ua haujlwm uas yog kom nce diuresis los ntawm kev thaiv qhov rov ua kom rov qab los ntawm sodium thiab chlorine ions nyob rau hauv thawj ntu ntawm raum tubules. Raws li qhov tshwm sim, kev nthuav tawm ntawm sodium, chlorine, thiab, raws li, dej nce ntxiv. Tsis tas li ntawd, qhov kev tawm ntawm lwm cov electrolytes - potassium thiab magnesium - tseem tab tom loj hlob. Cov nyhuv tshuaj diuretic / natriuretic ntawm txhua qhov mob thiazides thaum noj tshuaj ntau kawg yog kwv yees li qhov qub.

Natriuretic kev txiav txim thiab diuretic nyhuv tshwm sim hauv 2 teev, nce mus txog ib qib siab tom qab kwv yees li 4 teev.

Thiazide diuretics, ntxiv rau, los ntawm kev nce ntxiv ntawm kev nthuav dav ntawm bicarbonate ions txo kev ua haujlwm ntawm carbonic anhydrase, tab sis feem ntau cov nyhuv no tsis muaj zog qhia thiab tsis cuam tshuam rau cov zis pH.

Hydrochlorothiazide muaj cov khoom antihypertensive. Thiazide diuretics tsis cuam tshuam rau cov ntshav siab (BP).

Hypothiazide, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Cov tshuaj muaj hnub nyoog Hypothiazide noj tom qab noj mov.

Cov koob tshuaj yog xaiv tau ib tus zuj zus thaum kho. Kev ntsuas qhov ntsuas mob ntawm tus neeg mob, tus kws kho mob tau tshaj tawm txog qhov tsawg kawg nkaus ntawm cov tshuaj hypothiazide.

Thawj koob tshuaj rau cov neeg laus:

• Edematous syndrome ntawm ntau cov kev qhia tawm: 25-100 mg 1 zaug hauv ib hnub lossis 1 zaus hauv 2 hnub, mob hnyav - 200 mg ib hnub. Raws li kev kuaj mob hauv chaw kho mob, nws muaj peev xwm txo cov koob tshuaj kom tsawg li 25-50 mg ib hnub ib zaug lossis ib zaug txhua 2 hnub,
• Cov tsos mob ntawm tus mob premenstrual mob: 25 mg ib hnub ib zaug, kev tswj hwm pib los ntawm lub sijhawm cov tsos mob thawj zaug tshwm sim ua ntej pib coj khaub ncaws.
• Arterial hypertension (ua ke thiab tshuaj kho mob): 25-50 mg ib hnub ib zaug, rau qee cov neeg mob 12,5 mg txaus. Qhov siv tshuaj tsawg kawg yuav tsum tsis pub tshaj 100 mg rau ib hnub. Kev kho mob nyhuv yog manifested nyob rau hauv 3-4 hnub, rau kev pom zoo ntawm cov ntshav siab (BP) nws yuav siv 3-4 lub lis piam. Tom qab tshem tawm ntawm hypothiazide, cov nyhuv hypotensive kav rau 1 lub lim tiam. Txhawm rau tiv thaiv kom tsis txhob muaj zog hauv cov ntshav siab thaum lub sij hawm sib koom tes kho, qhov kev txo qis ntawm lwm cov neeg tiv thaiv kabmob tuaj yeem xav tau,
• Tus kab mob ntshav qab zib muaj ntshav ntau ntau: 50-150 mg ib hnub twg hauv ntau qhov tshuaj.

Kev siv tshuaj Hypothiazide rau menyuam yaus yog xam rau qhov hnyav ntawm tus menyuam. Qhov tshuaj kho tus menyuam txhua hnub feem ntau yog 1-2 mg rau 1 kg ntawm tus menyuam qhov hnyav lossis 30-60 mg rau 1 square meter. lub cev nto 1 zaug hauv ib hnub, rau cov menyuam muaj hnub nyoog 3 txog 12 xyoos - 37.5-100 mg ib hnub twg.

Sab sij huam

Kev siv cov tshuaj hypothiazide tuaj yeem ua rau cov kev mob tshwm sim hauv qab no:

• Cov kab mob hauv lub cev: mob tsis nco qab, zawv plab lossis quav tawv, cholecystitis, cholestatic daj ntseg, mob caj dab, leeg mob sialadenitis,
• Kev mob plab nyuv: ua tsis taus pa, tsis meej pem, maj mam ntawm cov txheej txheem kev xav, kev nrhaw, chim siab, nkees, mob leeg ntawm cov keeb kwm ntawm hypercalcemia, hypomagnesemia, hypokalemia, hyponatremia. Kev mob plawv tsis xwm yeem, lub qhov ncauj qhuav, nqhis dej, txawv txawv lossis qaug zog, hloov pauv ntawm lub siab ntsws lossis mob siab, mob plab thiab mob leeg, xeev siab, ntuav vim yog hypochloremic alkalosis (ntxiv rau, hypochloremic alkalosis tuaj yeem ua rau mob hepatic encephalopathy lossis coma). Glycosuria, hyperuricemia nrog kev txhim kho ntawm kev tawm tsam ntawm gout. Hyperglycemia, uas tuaj yeem ua rau kev txhim kho ntawm cov kab mob ntshav qab zib yav tas los mellitus. Kev siv tshuaj kho ntau dua tuaj yeem nce cov ntshav lipids,
• Kab mob hauv lub plawv: arrhythmia, vasculitis, orthostatic hypotension,
• Hematopoietic system: tsis tshua muaj - thrombocytopenia, leukopenia, hemolytic anemia, agranulocytosis, aplastic anemia,
• Tej leeg tsis muaj zog: ua kom pom kev plooj plooj ib ntus, mob taub hau, kiv taub hau, plooj plooj,
• Cov kab mob hauv lub raum: interstitial nephritis, ua haujlwm tsis zoo ntawm lub raum,
• Kev tsis haum tshuaj: urticaria, photosensitivity, necrotic vasculitis, purpura, Stevens-Johnson syndrome, anaphylactic tshua txog kev poob siab. Kab mob ntsws mob ntsws, nrog rau mob ntsws thiab tsis mob plawv-ntsws;
• Lwm yam: txo cov potency.

Cov lus qhia tshwj xeeb

Thaum lub sij hawm kawm kho mob ntev, nws yog qhov tsim nyog los tswj cov kab mob soj ntsuam uas tsis muaj dej-electrolyte tshuav nyiaj, tshwj xeeb tshaj yog nyob rau cov neeg mob uas lub siab tsis ua haujlwm, kab mob ntawm cov hlab plawv.

Kev siv cov hypothiazide txhawb kev ua kom zoo dua qub ntawm magnesium thiab potassium ions, yog li ntawd, nyob rau hauv cov txheej txheem sib luag nrog cov txheej txheem kev kho mob, yuav tsum tau ntsuas los tshem tawm lawv qhov tsis txaus.

Hauv cov neeg mob uas lub raum tsis ua haujlwm, kev tsim lub peev xwm tshem tawm yuav tsum muaj kev tiv thaiv ib puag ncig; thaum muaj oliguria, cov lus nug txog kev tshem tawm hypothiazide yuav tsum tau hais daws.

Hauv cov neeg mob uas lub siab tsis ua haujlwm, thiazides yuav tsum siv nrog ceev faj, vim tias qhov kev hloov me me ntawm cov dej-electrolyte tshuav nyiaj li cas thiab cov ntshav ammonia qib tuaj yeem ua rau mob hepatic tsis nco qab.

Kev siv cov hypothiazide hauv cov neeg mob uas mob hnyav thiab mob txha caj qaum yuav tsum muaj kev saib xyuas tshwj xeeb.

Lub sij hawm ntev kho mob latent thiab tshwm sim ntshav qab zib mellitus yuav tsum muaj nrog kev soj ntsuam cov kab mob ntawm cov khoom noj uas ua rau cov metabolism thiab cov tshuaj hloov kho cov tshuaj hypoglycemic.

Kev tshuaj ntsuam tas li ntawm qhov xwm txheej xav tau cov neeg mob uas ua tsis taus cov metabolism uric acid.

Kev kho mus sij hawm ntev, nyob rau cov tsis tshua muaj, tuaj yeem ua rau muaj kev hloov kho pathological hauv cov qog parathyroid.

Cev xeeb tub thiab lactation

Hydrochlorothiazide dhau los ntawm qhov chaw tiv thaiv kab mob, thiab yog li ntawd muaj kev pheej hmoo ntawm me nyuam hauv plab / tawv nqaij daj ntseg, mob plab zais, thiab lwm yam kev tsis zoo.

Kev siv cov tshuaj hypothiazide hauv thawj lub hlis thaum cev xeeb tub yog nruj me ntsis contraindicated. Hauv qhov II - III trimesters, cov tshuaj tau hais tseg tsuas yog tsim nyog, thaum xav tias yuav muaj txiaj ntsig rau leej niam yog qhov siab dua qhov kev pheej hmoo rau tus me nyuam hauv plab.

Hydrochlorothiazide ua rau hauv lactation nrog rau niam mis. Yog tias koj xav siv nws nyob rau lub sijhawm no, koj yuav tsum tsis txhob pub mis niam.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

nyob rau hauv lub blister 20 pcs., hauv daim ntawv thawv thawv 1 blister.

Qhia Txog Hypothiazide ®

arterial hypertension (siv ob qho tib si hauv monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj antihypertensive),

edema syndrome ntawm ntau lub hauv paus (mob plawv tsis ua haujlwm, nephrotic syndrome, premenstrual syndrome, mob glomerulonephritis, mob raum tsis ua haujlwm, portal tawg, kho corticosteroids),

tswj hwm ntawm polyuria, feem ntau nrog nephrogenic ntshav qab zib insipidus,

kev tiv thaiv ntawm kev tsim cov pob zeb hauv cov genitourinary huam hauv cov neeg mob ntxim nyiam (txo ntawm hypercalciuria).

Cev xeeb tub thiab lactation

Hydrochlorothiazide hla lub teeb meem ntawm thaj chaw. Kev siv cov tshuaj nyob rau hauv thawj peb lub hlis ntawm cev xeeb tub yog contraindicated. Hauv II thiab III trimesters ntawm cev xeeb tub, cov tshuaj tuaj yeem raug cai tsuas yog muaj xwm txheej ceev, thaum muaj txiaj ntsig rau leej niam tshaj qhov yuav ua rau muaj kev pheej hmoo rau tus menyuam thiab / lossis menyuam. Muaj kev pheej hmoo ntawm kev txhim kho jaundice ntawm tus me nyuam hauv plab lossis tus menyuam tshiab, thrombocytopenia thiab lwm yam kev rau txim.

Cov tshuaj kis mus rau niam mis, yog li ntawd, yog tias kev siv cov tshuaj yog qhov tsim nyog tiag tiag, kev pub mis niam yuav tsum tsis tsum.

Kev Hypothiazide

Hypothiazide yog cov tshuaj diuretic hluavtaws los ntawm pab pawg benzothiadiazine. Cov nyhuv diuretic ntawm hypothiazide yog vim qhov txo qis ntawm kev nqus ntawm chlorine, sodium ions hauv lub raum plab hlaus. Kev ua kom muaj ntsev ntau ntxiv los ntawm lub cev ua rau poob ntawm cov dej. Raws li qhov kev tshem tawm dej, qhov ntim ntawm lub cev ntshav kom tsawg, uas ua rau cov ntshav siab poob qis (yog tias nws nce ntxiv, ntshav siab tsis poob). Cov tshuaj kuj tseem txhawb nqa cov kev zam ntawm cov poov tshuaj, bicarbonates thiab magnesium ions los ntawm lub cev, tab sis kom tsawg dua.

Cov nyhuv tshuaj tso tawm (diuretic) pib 1-2 teev tom qab noj tshuaj, nce mus txog qhov siab kawg tom qab 4 teev thiab kav ntev txog 6-12 teev. Kev siv tshuaj ntev ntawm hypothiazide tsis txo nws cov nyhuv diuretic. Txwv txiav kev siv ntsev nrog cov zaub mov ua kom cov nyhuv hypotensive ntawm cov tshuaj.

Intraocular siab kuj txo qis nrog Hypothiazide. Cov tshuaj tuaj yeem hla tus placental barrier. Muaj sia nyob hauv kev tso zis thiab mis niam. Nrog rau lub raum tsis ua haujlwm, qhov tso tawm ntawm cov tshuaj yog txo qeeb qeeb.

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj yog hydrochlorothiazide.

Kev Kho Mob Hypothiazide

Nrog rau kev rog, muaj kev nyiam ua kom rov qab muaj dej hauv lub cev vim qhov ua kom hydrophilicity ntawm cov ntaub so ntswg. Ntxiv rau, feem ntau tiv thaiv keeb kwm yav dhau los ntawm kev rog dhau, kev mob plawv tsis ua hauj lwm, nce cov dej hauv lub cev. Tom qab ntawd muaj qhov yuav tsum tau ua ntawv thov nyob rau hauv kev kho mob tsis tsuas yog mob tshuaj, tab sis kuj tseem siv tshuaj diuretics. Ntawm cov diuretics, hypothiazide feem ntau siv, muab nws cov diuretic zoo thiab tsis tshua muaj tshwm sim kev phiv tshuaj.

Txawm li cas los xij, kev siv tshuaj hypothiazide rau kom poob phaus yuav tsum ua tib zoo saib xyuas thiab tsuas yog qhia los ntawm kws kho mob. Kev siv cov diuretic uas tsis muaj lub laj thawj zoo no tuaj yeem ua rau muaj kev txhaum loj - cov kev mob rog tsis rog yuav ua edematous rau qhov laj thawj uas hais txog kev siv diuretics mus ntev ua rau muaj txiaj ntsig tsis sib thooj: cov kua hauv cov nqaij ua kom sai dua.

Nws yog qhov yooj yim dua thiab zoo dua los tshem tawm cov kua dej ntau hauv lub cev siv decoctions thiab infusions ntawm cov nroj tsuag tshuaj (bearberry, horsetail, thiab lwm yam).
Ntau txog kev poob phaus