Rosulip ntsiav tshuaj: cov lus qhia thiab tshuaj xyuas tus neeg mob

Rosulip yog muaj nyob rau hauv round biconvex ntsiav tshuaj, dawb los sis yuav luag dawb hauv xim, txheej muaj nyob rau hauv daim ntawv ntawm lub plhaub zaj duab xis, ntawm ib sab yog engraving "E", nyob rau sab nraud - "591" (ntau npaum 5 mg), "592" (ntau npaum 10 mg ), “593” (noj 20 mg), “594” (noj 40 mg). Cov ntsiav tshuaj no tau ntim rau hauv blisters rau 7 daim, hauv daim npav cardboard muaj 2, 4 thiab 8 blisters.

Pharmacodynamics thiab pharmacokinetics

Rosuvastatin ua cov tshuaj muaj zog yog kev xaiv cov sib tw enzyme inhibitor HMG-CoA reductaseuas catalyzes hloov dua siab tshiab ntawm 3-hydroxy-3-methylglutaryl CoA rau mevalonate- muaj tswv yim ua ntej roj.

Vim tias qhov nce ntawm tus naj npawb ntawm LDL receptors rau hepatocytes nyob rau hauv kev cuam tshuam ntawm rosuvastatinqhov nqus thiab catabolism ntawm LDL yog kho kom zoo, thiab cov txheej txheem hluavtaws tseem raug kev tsim txom lipoproteinstsawg kawg nkaus ntom hauv daim siab. Tsis tas li ntawd, rosuvastatin muaj cov tshuaj tseem ceeb hauv cov kab mob biochemical xws li:

nce siab rojthiab cov ntsiab lus siab ceev lipoproteins (abbr. Xs - HDL),
txo qhov kev xav ntawm tag nrho rojnrog triglycerides,
txo qhov kev xav zoo apolipoprotein B(APOB), triglyceridesli qub lipoproteinstsawg heev ntom (abbr. TG-VLDLP),
nce cov ntsiab lus apolipoprotein A-Kuv (APOA-I),
txo cov ntsiab lus siab rojnrog tsis tshua muaj ntom lipoproteins (abbr. Xs - LDL), rojthiab tsis-HDL(Xc - tsis-HDL) rojnrog lipoproteins tsawg kawg nkaus ntom (Xc - VLDLP), nrog rau lawv tus lej sib piv, qhia raws li: Xc - LDL / Xc - HDL, tag nrho. Xc / Xc - HDL, Xc - tsis-HDL / Xc - HDL, APOV / APOA-I.

Feem ntau, txoj kev kho kom zoo tuaj yeem ua tiav nyob hauv ib lub lis piam, thiab tom qab 2 lub lis piam ntawm kev kho, qhov ua tau zoo ntawm kwv yees li 90 feem pua ntawm qhov siab tshaj plaws tau tiav. Yuav kom ua tiav cov txiaj ntsig siab tshaj plaws, koj xav tau 4 lub lim tiam ntawm txoj kev kho, thiab tom qab ntawd tswj kev noj mov kom tsawg.

Tshaj ntshav siab tshaj plaws rosuvastatinnrog lub qhov ncauj tswj hwm tau tiav tom qab 5 teev. Cov theem ntawm cov tsis raug mob bioavailability yog nce txog 20% (nce ntxiv hauv qhov sib npaug ntawm cov koob tshuaj). RosuvastatinRaug rau ntawm kev nqus los ntawm daim siab, nws tshwm sim hauv kev sib txuas ntawm cov roj (cholesterol) thiab LDL-C yog cov tawm. Kwv yees li 90% ntawm cov tshuaj nquag khi rau cov protein nyob hauv ntshav ntshav (uantej. albumin).

Kev zom zaub mov rosuvastatin: raws li cov-txheej substrate isoenzymes(lub ntsiab CYP2C9) cytochrome P450, cov khoom siv roj ntsha tseem ceeb yog ua haujlwm N-desmethyl rosuvastatintsaug zog lactone metabolites.

Yuav luag 90% ntawm cov koob tshuaj hloov pauv tsis hloov pauv rosuvastatintshem tawm los ntawm txoj hnyuv, 5% ntawm qhov koob tshuaj los ntawm lub raum. Kev tshem tawm ib nrab-lub neej yog 19 teev, tsis hais txog ntawm qhov nce hauv koob tshuaj.

Kev ntsuas rau siv

hom IIa raws li kev faib tawm ntawm Fredrickson thawjhypercholesterolemiahom IIbsib xyaw hypercholesterolemia (ntxiv rau kev noj haus),
txuam nrog kev noj hausthiab lwm txoj kev kho mob uas tuaj yeem txo cov ntshav lipids (piv txwv li apheresis ntawm LDL) nrog roj ntsha homozygous hypercholesterolemia,
hom IV raws li kev faib tawm ntawm Fredrickson hypertriglyceridemiantxiv rau kev noj haus,
txuam nrog kev noj hausthiab kev kho mob uas txo cov theem ntawm tag nrho. Xs, Xs-LDL kom nce qeeb atherosclerosis,
rau kev tiv thaiv ntawm ntau yam mob plawv mob, suav nrog: myocardial infarction, mob stroke, arterial revascularization tsis muaj kev kuaj mob hauv chav kho mob, tab sis nrog kev pheej hmoo ntawm kev loj hlob mob plawv plawvnyob rau hauv qhov muaj kev pheej hmoo yam xws li leeg ntshav siab, tsis tshua muaj HDL-C, haus luam yeeb, muaj nyob hauv tsev neeg keeb kwm ntawm kev txhim kho kab mob ischemic thaum ntxov.

Cov Yuav Tsum Muaj

kev tiv thaiv tsis haumrau lub Cheebtsam ntawm Rosulip,
nquag ua haujlwm ntawm daim siab mob, suav nrog kev ua tsis raug ntxiv hauv cov ntshav dej transaminase,
kev ua haujlwm tsis zoo rau lub raum, nrog rau kev ua kom pom tseeb neeg tsim tswvtxog li 30 ml ib feeb twg,
mob hlwbthiab predisposition rau mob myotoxic,
kev kho Cyclosporine,
cov poj niam thaum cev xeeb tub thiab lactation,
hnub nyoog pab pawg muaj txog 18 xyoo,
nyob rau hauv kev sib txuas nrog cov ntsiab lus hauv kev npaj lactosecontraindication yog nws intolerance, xam phajenzyme - lactasessuav nrog piam thaj galactose malabsorption.

Cov tshuaj no tau siv nrog ceev faj yog tias muaj kev pheej hmoo ntawm kev loj hlob. myopathiestxawm yog rhabdomyolysis, lub raum tsis ua hauj lwmkeeb kwm kab mob siab, nrog sepsis, arterial hypotension, hypothyroidism.

Ntxiv rau, nrog kev ceev faj, kev siv tshuaj Rosulip yog muab rau cov neeg mob uas haus ntau dhau cawvtshaj 65 xyoos, Neeg Esxias haiv neeg thov kev pab fibratesmuaj ntshav nce ntxiv ntawm rosuvastatin, phais hnyav lossis raug mob.

Noj ntau dhau

Thaum noj ntau dhau ntawm rosuvastatin, kev kho cov tsos mob yuav tsum tau nqa tawm, vim hais tias meej tshuaj tiv thaiv kab mob niaj hnub no tsis muaj nyob, tab sis muaj kev vam meej hemodialysis tsis zoo li. Ib qho ntxiv, nws yog ib qhov tsim nyog yuav tsum tau ua cov haujlwm los tswj lub luag haujlwm tseem ceeb, nws raug nquahu kom tswj hwm cov theem ntawm dej num CPK thiab lub siab ua haujlwm.

Kev sib txuam

Nrog Cyclosporin AUCrosuvastatinnce thaj tsam xya zaus tshaj li cov neeg ua haujlwm pab dawb noj qab haus huv, ntxiv rau, ntshav plos concentration ntawm rosuvastatin nce ntxiv los ntawm kaum ib zaug, thiab Cyclosporine tsis hloov.
Nrog Vitamin K kev thaiv kev(piv txwv li, Warfarin) thaum pib ntawm Rosulip txoj kev kho lossis nrog qhov nce ntxiv ntawm cov tshuaj, PV thiab MHO yuav nce. Kev tshem tawm ntawm Rosulip lossis txo qhov kev txhaj tshuaj tuaj yeem ua rau MHO txo qis, yog li kev tswj hwm ntawm MHO yog qhov tsim nyog.
Kev sib xyaw ntawm rosuvastatin nrog Gemfibrozilthiab lipid-txostxhais tau tias tuaj yeem ua rau lub siab ob npaug ntawm qhov siab tshaj plaws ntshav plasma thiab AUC ntawm rosuvastatin.
Nrog Ezetimibepharmacodynamic kev sib cuam tshuam thiab kev txhim kho cov kev mob tshwm sim yog qhov ua tau.
Nrog protease inhibitors - ib qho tseem ceeb nce ntxiv hauv kev kis mob ntawm rosuvastatin yog ua tau.
Nrog antacids, ib qho kev txo qis hauv plasma concentration ntawm rosuvastatin kwv yees li 50% yog pom.
Nrog Erythromycin- qhov txo qis hauv AUC ntawm rosuvastatin los ntawm yuav luag 20% thiab Cmax los ntawm 30%, tej zaum vim muaj cov hnyuv nce ntxiv nyob rau hauv kev txiav txim ntawm erythromycin.
Nrog tshuaj tiv thaiv qhov ncauj thiab sijhawm kev hloov kho tshuaj hormones AUC ntawm ethinyl estradiol (los ntawm 26%) thiab norgestrel (los ntawm 34%) nce.
Kev siv tshuaj uake nrog rosuvastatin nrog Itraconazole(ib qho inhibitor ntawm CYP3A4 isoenzyme) ua rau muaj kev nce ntxiv hauv AUC ntawm rosuvastatin los ntawm 28%, uas yog ib qho kev tsis txaus siab hauv chaw kho mob.

Cov Lus Qhia Rosulip

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 54 rubles. Cov analogue yog pheej yig dua los ntawm 384 rubles

Qhov sib tw raws cov cim

Nqe los ntawm 324 rubles. Cov analogue yog pheej yig dua los ntawm 114 rubles

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 345 rubles. Cov analogue yog 93 rubles pheej yig dua

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 369 rubles. Cov analogue yog pheej yig dua los ntawm 69 rubles

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 418 rubles. Cov analogue yog pheej yig los ntawm 20 rubles

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 660 rubles. Cov analogue ntau kim dua los ntawm 222 rubles

Qhov sib tw raws cov cim

Nqe txij li 737 rubles. Cov analogue kim dua ntawm 299 rubles

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 865 rubles. Cov analogue kim dua ntawm 427 rubles

Pharmacological kev txiav txim

Rosuvastatin yog qhov xaiv thiab kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas catalyzes qhov hloov pauv ntawm 3-hydroxy-3-methylglutaryl-coenzyme A rau mevalonate, uas yog ib qho ua ntej ntawm cov roj (Xc). Rosuvastatin tsub kom ntau dua ntawm cov LDL receptors nyob rau saum npoo ntawm daim siab, uas nce ntxiv kev nqus thiab catabolism ntawm LDL, thiab tseem inhibits cov synthesis ntawm VLDL hauv lub siab. Raws li qhov tshwm sim, tag nrho cov lej ntawm VLDL thiab LDL cov teeb meem tau txo qis.

Nws txo cov tshuaj lom neeg muaj roj lipoprotein ntau (roj ntau ntau) roj (HDL-C), cov roj (cholesterol) thiab triglycerides ntau, thiab tseem ua rau cov lipoprotein cov roj (lipoprotein cholesterol) tsawg tsawg (HDL-C). Ntxiv rau, rosuvastatin txo qis kev ua kom muaj apolipoprotein B (ApoB), roj (HDC) cov roj (Xc-tsis-HDL roj), cov roj lipoprotein tsawg (lipoprotein chinin) ntau npaum li cas, thiab muaj ntau yam lipoprotein triglycerides (TG-VLDL) thiab nce cov ntsiab lus ntawm apolipoprotein I (Apolipoprotein I) )

Rosuvastatin kuj txo qis ntawm Xs-LDL / Xs-HDL, cov roj (cholesterol) tag nrho / Xs-HDL, Xs-tsis-HDL / Xs-HDL thiab ApoV / ApoA-I.

Kev kho zoo li cas ntawm cov tshuaj tshwm hauv ib lub lis piam tom qab pib ntawm kev kho mob. Hauv 2 lub lim tiam ntawm txoj kev kho, qhov kev ua tau zoo mus txog qib uas yog 90% ntawm qhov ua tau ntau tshaj plaws. Kev kho mob siab tshaj plaws feem ntau ua tiav los ntawm 4 lub lim tiam ntawm kev kho thiab tswj nrog kev siv tas li.

Cov kev nyab xeeb thiab kev ua haujlwm ntawm rosuvastatin hauv cov menyuam yaus yog cov tsis muaj pov thawj. Rau pawg no ntawm cov neeg mob, cov kev paub ntawm kev siv tshuaj yog txwv rau qee tus neeg mob tsawg (hnub nyoog 8 xyoo thiab laus dua) nrog homozygous kab mob hypercholesterolemia hom mob.

Cov Tshuaj Pharmacokinetics

C_max ntshav rosuvastatin mus txog kwv yees li 5 teev tom qab noj. Qhov tiag bioavailability ntawm cov tshuaj yog kwv yees li 20%.

Rosuvastatin yog sib zog nqus los ntawm lub siab, qhov twg qhov tseem ceeb synthesis ntawm cov roj thiab txhaws ntawm LDL-C tshwm sim. V_d rosuvastatin ncav cuag 134 litres.

Txog 90% ntawm rosuvastatin khi rau cov ntshav plasma protein, feem ntau yog albumin.

Rosuvastatin muaj qee cov roj ntsha tsis txaus (kwv yees li 10%) hauv lub siab. Nws yog cov-tub ntxhais tsis tseem ceeb cov substrate rau isoenzymes ntawm cytochrome P450 system. Lub ntsiab isoenzyme koom nrog hauv cov metabolism hauv rosuvastatin yog CYP2C9. Isoenzymes CYP2C19, CYP3A4 thiab CYP2D6 tsawg koom nrog cov metabolism.

Lub ntsiab tseem ceeb nrhiav pom ntawm rosuvastatin yog N-desmethyl thiab lactone metabolites. N-desmethyl yog kwv yees li 50% tsis tshua muaj siab tshaj li rosuvastatin, lactone metabolites yog cov tshuaj pharmacologically tsis voos. Ntau tshaj li 90% ntawm pharmacological kev ua ub no hauv inhibiting ncig HMG-CoA reductase yog muab los ntawm rosuvastatin, qhov seem yog metabolites.

Kwv yees li 90% ntawm kev txhaj tshuaj ntawm rosuvastatin yog pom tsis txawv txav los ntawm txoj hnyuv.

Kwv yees li 5% ntawm qhov koob tshuaj yog tawm tsis txawv txav los ntawm lub raum. T_1/2 Cov tshuaj los ntawm cov ntshav ntshav yog kwv yees li 19 teev thiab tsis hloov nrog qhov nce ntawm qhov tshuaj. Lub plasma tshem ntawm rosuvastatin nce mus txog qhov nruab nrab ntawm 50 l / h (coefficient ntawm kev sib txawv - 21.7%).

Ib yam li lwm HMG-CoA reductase inhibitors, cov roj ntsha ua rau cov xaim hluav taws xob tau koom nrog kev kho mob hepatic ntawm rosuvastatin, uas ua lub luag haujlwm tseem ceeb hauv kev kho mob hepatic ntawm rosuvastatin.

Cov kab mob kev nyab xeeb ntawm cev nqaij daim tawv ntawm rosuvastatin nce ntxiv hauv kev faib ua feem. Thaum siv cov tshuaj ob peb zaug hauv ib hnub, cov tsis haum pharmacokinetic tsis hloov.

Pharmacokinetics hauv cov pab pawg neeg mob tshwj xeeb

Poj niam txiv neej thiab lub hnub nyoog tsis muaj kev xav paub pom tseeb hauv lub chaw muag tshuaj ntawm rosuvastatin.

Cov kev tshawb fawb Pharmacokinetic qhia tau nce kwv yees ob zaug nce ntxiv hauv nruab nrab ntawm AUC thiab C_max plasma rosuvastatin nyob rau hauv cov neeg mob ntawm haiv neeg Mongoloid (Nyiv, Suav, Tebchaws Philippines, Nyab Laj thiab Kauslim) piv nrog cov sawv cev ntawm haiv neeg Caucasian, hauv cov neeg mob Indian, kev nce qib hauv nruab nrab AUC thiab C yog qhia_max 1,3 zaug. Kev tsom xam tsis tau qhia txog qhov sib txawv ntawm cov chaw muag tshuaj ntawm cov neeg sawv cev ntawm Caucasian thiab cov neeg sawv cev ntawm cov haiv neeg Negroid.

Hauv cov neeg mob uas mob raum me thiab mob raum tsis ua haujlwm, ntshav plasma concentration ntawm rosuvastatin lossis N-desmethyl tsis hloov pauv ntau. Hauv cov neeg mob uas lub raum tsis txaus (CC tsawg dua 30 ml / min), qhov kev tso tshuaj ntawm rosuvastatin hauv cov ntshav ntshav yog 3 zaug ntau dua, thiab cov concentration ntawm N-desmethyl yog 9 zaug ntau dua ntawm cov neeg ua haujlwm noj qab haus huv. Lub plasma concentration ntawm rosuvastatin hauv cov neeg mob ntawm hemodialysis yog kwv yees li 50% siab dua hauv cov neeg ua haujlwm noj qab haus huv.

Cov neeg mob uas muaj ntau theem ntawm daim siab ua kom pom tias tsis muaj qhov nce hauv T_1/2 rosuvastatin (cov neeg mob uas muaj qhov qhab nia 7 lossis qis dua ntawm qhov Child-Pugh nplai). 2 cov neeg mob uas tau qhab nia ntawm 8 thiab 9 nyob rau ntawm Child-Pugh nplai qhia tau nce T ntau ntxiv_1/2tsawg kawg 2 zaug. Tsis muaj kev paub dhau los ntawm kev siv rosuvastatin hauv cov neeg mob uas tau tus qhab nia siab dua 9 ntawm Child-Pugh nplai.

- thawj hypercholesterolemia (hom IIa raws li Fredrickson) lossis sib xyaw hypercholesterolemia (hom IIb raws li Fredrickson) yog cov khoom noj ntxiv rau kev noj haus, thaum noj zaub mov noj thiab lwm txoj kev siv tshuaj tsis raug ntawm kev kho mob (piv txwv, qoj ib ce, poob phaus) tsis txaus,

- homozygous kab mob hypercholesterolemia ua ib qho kev txhawb ntxiv rau kev noj haus thiab lwm txoj kev kho mob txhawm rau txo qis lipid ntau nyob rau hauv cov ntshav (piv txwv li, LDL apheresis), zoo li nyob rau qee kis qhov cov hau kev no tsis muaj txiaj ntsig txaus,

- hypertriglyceridemia (yam IV raws Fredrickson) ua rau kev noj zaub mov ntxiv,

- txhawm rau maj mam txhim kho cov mob atherosclerosis los ntxiv rau kev noj haus hauv cov neeg mob, suav nrog cov uas pom pom tias muaj kev kho kom txo qis qib Chs thiab Chs-LDL,

- kev tiv thaiv ntawm cov kev mob plawv tseem ceeb (mob hlab ntsha tawg, myocardial infarction, hlab ntsha hloov pauv) hauv cov neeg laus tsis muaj kev soj ntsuam cov kab mob ntawm txoj hlab ntshav txhaws, tab sis nrog kev pheej hmoo ntawm nws txoj kev loj hlob (dhau 50 xyoo rau cov txiv neej thiab ntau dua 60 xyoo rau cov poj niam, nce concentration ntawm C-reactive protein) (Mg2 mg / L) nyob rau ntawm qhov tsawg kawg ntawm ib qho kev pheej hmoo ntxiv, xws li mob ntshav siab, tsis tshua muaj siab HDL-C, haus luam yeeb, tsev neeg muaj keeb kwm thaum pib mob ntshav siab.

Kev noj tshuaj ntxiv

Cov tshuaj tau noj ntawm qhov ncauj. Cov ntsiav tshuaj yuav tsum nqos tag nrho, ntxuav nrog dej, tsis ntxo lossis zom zaws. Rosulip ® tuaj yeem noj tau txhua lub sijhawm ntawm lub hnub, tsis hais noj zaub mov.

Ua ntej pib kev kho mob nrog Rosulip ®, tus neeg mob yuav tsum tau noj cov zaub mov kom zoo nrog cov ntsiab lus roj tsawg. Tus neeg mob yuav tsum ua raws txoj kev noj haus txhua ntu ntawm txoj kev kho. Cov koob tshuaj ntawm cov tshuaj yuav tsum tau xaiv ib tus zuj zus nyob ntawm qhov ntsuas thiab kho qhov lus teb rau kev kho mob, ua raws li cov lus pom zoo tam sim no ntawm cov qib lipid.

Qhov pom zoo pib koob ntawm Rosulip ® rau cov neeg mob pib noj cov tshuaj, lossis rau cov neeg mob hloov mus los ntawm lwm HMG-CoA reductase inhibitors, yog 5 lossis 10 mg 1 zaug / hnub. Thaum xaiv cov tshuaj xub thawj, ib qho yuav tsum tau coj los ntawm tus neeg mob cov ntsiab lus roj thiab coj mus rau hauv qhov kev pheej hmoo ntawm kev tsim cov hlab plawv mob, thiab nws tseem yuav tsum tau soj ntsuam qhov muaj feem ntawm kev phiv tshuaj. Yog tias tsim nyog, tom qab 4 lub asthiv cov tshuaj yuav raug nce siab.

Tom qab thov kev noj tshuaj nyob rau hauv ntau dhau ntawm kev pom zoo thawj zaug rau 4 lub lis piam, nws qhov kev nce ntxiv rau 40 mg tuaj yeem nqa tawm tsuas yog hauv cov neeg mob uas muaj mob hypercholesterolemia thiab muaj kev pheej hmoo siab heev ntawm cov hlab plawv mob (tshwj xeeb tshaj yog nyob rau cov neeg mob nrog tsev neeg hypercholesterolemia) uas tsis tau tiav qhov xav tau kev tshwm sim ntawm kev kho mob thaum siv nyob rau hauv ib koob tshuaj 20 mg, thiab uas yuav nyob rau hauv kev saib xyuas ntawm ib tus kws tshwj xeeb.Pom zoo tshwj xeeb kev saib xyuas ntawm cov neeg mob tau txais cov tshuaj hauv ib koob tshuaj 40 mg yog pom zoo.

Rau kho cov neeg mob tshaj 65 xyoo Qhov pom zoo kom pib noj yog 5 mg. Tsis tas yuav muaj lwm qhov hloov pauv uas cuam tshuam txog lub hnub nyoog ntawm tus neeg mob.

Cov neeg mob uas lub raum me me los sis mob raum tsis ua haujlwm Tsis tas yuav txhaj koob tshuaj. Cov neeg mob uas tsis tshua mob raum lub raum (CC tsawg dua 60 ml / min) Qhov pom zoo thawj zaug ntawm 5 mg yog kev pom zoo. Ib koob tshuaj ntawm 40 mg yog contraindicated hauv cov neeg mob nrog mob raumCov. Ntawm mob raum tsis ua haujlwm Rosulip ® sib xyaw nrog hauv ib koob tshuaj.

Thaum muab tshuaj rau hauv cov tshuaj li 10 mg thiab 20 mg, koob tshuaj pom zoo thawj zaug rau cov neeg mob ntawm haiv neeg Mongoloid yog 5 mg. Kev siv cov tshuaj hauv ib koob ntawm 40 mg yog contraindicated hauv cov neeg mob ntawm haiv neeg Mooboid.

Thaum sau tshuaj rau hauv cov tshuaj ntawm 10 mg thiab 20 mg, qhov pom zoo thawj zaug rau cov neeg mob predisposed rau myopathy yog 5 mg. Kev tswj hwm ntawm cov tshuaj ntawm ib koob tshuaj 40 mg yog contraindicated rau hauv cov neeg mob uas muaj qee yam uas yuav qhia tau qhov kev xav ua ntej rau kev txhim kho ntawm myopathy.

Tom qab 2-4 lub lis piam ntawm kev kho mob thiab / lossis nrog kev nce ntxiv ntawm qhov tshuaj ntawm Rosulip ®, kev saib xyuas cov lipid metabolism yog qhov tsim nyog, yog tias tsim nyog, yuav tsum tau hloov kho koob tshuaj.

Sab sij huam

Thaum lub sij hawm kev kho mob nrog rosuvastatin, feem ntau cov teeb meem tsis hnyav thiab cov sij hawm hloov pauv tau muab sau cia. Ib yam li lwm yam HMG-CoA reductase inhibitors, qhov ntau zaus ntawm cov kev tsis haum nrog rosuvastatin txoj kev kho yog koob tshuaj.

Kev faib tawm ntawm qhov tshwm sim tsis zoo raws li qhov muaj tshwm sim ntau zaus: feem ntau (los ntawm> 1/100 txog 1/1000 txog 1/10 000 rau

Cev xeeb tub thiab lactation

Rosulip ® yog sib kis hauv kev xeeb tub thiab lactation (pub niam mis). Thaum kuaj pom tias cev xeeb tub thaum kho, kev siv cov tshuaj yuav tsum tsis ua mus ntxiv tam sim ntawd.

Cov poj niam ntawm kev muaj me nyuam hnub nyoog yuav tsum siv cov hauv kev tsim nyog los tiv thaiv kom tsis txhob muaj menyuam yaus.

Txij li cov roj (cholesterol) thiab nws cov khoom siv roj ntsha (biosynthesis) yog qhov tseem ceeb rau kev txhim kho menyuam hauv plab, qhov kev pheej hmoo muaj peev xwm los tiv thaiv HMG-CoA reductase ntau dua li cov txiaj ntsig ntawm kev siv tshuaj.

Tsis muaj ntaub ntawv hais txog kev faib cov rosuvastatin nrog rau niam cov kua mis, yog li yog tias koj yuav tsum siv cov tshuaj thaum lactation, kev pub mis niam yuav tsum tsis ua haujlwm ntxiv.

Siv rau lub siab ua haujlwm tsis zoo

Cov tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 10 thiab 20 mg yog contraindicated nyob rau hauv daim siab mob siab nyob rau hauv kev ua ntu, nrog rau kev nce ntxiv ntawm cov ntshav transaminase kev ua si thiab ib qho kev nce hauv cov ntshav transaminase kev ua si (ntau dua 3 zaug piv nrog VGN). Nrog kev ceev faj, Rosulip ® yuav tsum tau kho nyob rau ib koob tshuaj 10 thiab 20 mg rau keeb kwm ntawm kab mob siab.

Cov tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 40 mg yog contraindicated nyob rau hauv daim siab mob siab nyob rau hauv kev ua ntu, nrog rau kev nce ntxiv ntawm cov ntshav dej ntawm kev hloov pauv thiab ib qho kev nce hauv kev ua haujlwm ntawm transaminases hauv cov ntshav cov ntshav (ntau dua 3 zaug piv nrog VGN), qhov kev paub ntawm kev siv tshuaj hauv cov neeg mob uas muaj tus qhab nia siab dua 9 ntawm Child-Pugh nplai ploj lawm. Nrog kev ceev faj, Rozulip ® yuav tsum tau txhaj tshuaj kom siv tshuaj ntawm 40 mg rau keeb kwm ntawm kab mob siab.

Siv rau lub raum tsis zoo muaj nuj nqi

Cov tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 10 thiab 20 mg yog contraindicated nyob rau hauv kev mob raum loj (CC tsawg dua 30 ml / min). Nrog kev ceev faj, cov tshuaj yuav tsum yog kws kho mob ntawm koob tshuaj 10 thiab 20 mg rau lub raum tsis ua haujlwm.

Cov tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 40 mg yog contraindicated nyob rau hauv sim mob raum tsis ua haujlwm (CC tsawg dua 60 ml / min). Nrog kev ceev faj, cov tshuaj yuav tsum tau siv nyob rau hauv daim ntawv ntawm 40 mg ntsiav tshuaj nyob rau hauv cov neeg mob uas tsis mob raum (CC ntau dua 60 ml / min).

Cov lus qhia tshwj xeeb

Thaum siv cov tshuaj Rosulip ® hauv ib koob tshuaj 40 mg, pom zoo kom soj ntsuam cov cim qhia txog lub raum.

Thaum siv cov tshuaj Rosulip ® hauv txhua qhov koob tshuaj, tshwj xeeb tshaj qhov ntau tshaj 20 mg, kev txhim kho ntawm myalgia, myopathy thiab, nyob rau qee kis, rhabdomyolysis tau tshaj tawm.

Kev txiav txim siab ntawm kev ua haujlwm ntawm CPK yuav tsum tsis txhob ua tomqab kev tawm dag zog lub cev lossis thaum muaj lwm qhov laj thawj uas ua rau muaj kev nce qib ntawm CPK kev ua haujlwm, uas tuaj yeem ua rau kev txhais tsis raug ntawm cov txiaj ntsig. Yog tias qhov pib ua haujlwm ntawm CPK tau nce siab (5 zaug siab dua li VGN), tom qab 5-7 hnub, yuav tsum ntsuas qhov ntsuas zaum ob. Koj yuav tsum tsis txhob pib kho yog tias kev rov ua ntsuas dua tau lees paub qhov nce ntawm KFK (5 npaug ntau dua li VGN).

Thaum sau tshuaj rau Rosulip ® (ntxiv rau lwm qhov HMG-CoA reductase inhibitors) hauv cov neeg mob uas muaj kev pheej hmoo rau mob rhabdomyolysis, nws yog qhov yuav tsum txiav txim siab txog qhov sib piv ntawm cov txiaj ntsig uas xav tau thiab qhov pheej hmoo txaus ntshai thiab kev soj ntsuam kev soj ntsuam.

Tus neeg mob yuav tsum raug qhia paub txog qhov yuav tsum tau ceeb toom rau tus kws kho mob tam sim ntawd ntawm cov kev mob tshwm sim sai sai ntawm cov leeg mob, mob leeg tsis muaj zog lossis mob plab, tshwj xeeb tshaj yog ua ke nrog malaise thiab kub taub hau. Hauv cov neeg mob no, CPK cov haujlwm yuav tsum raug txiav txim. Kev kho yuav tsum tsis ua ntxiv yog tias qhov kev ua ntawm CPK tau nce siab (ntau dua 5 zaug piv nrog VGN) lossis yog tias cov leeg mob tau tawm thiab ua rau muaj kev kub ntxhov txhua hnub (txawm hais tias qhov haujlwm ntawm CPK 5 zaug tsawg dua piv rau VGN). Yog tias cov tsos mob ploj, thiab CPK cov haujlwm rov qab mus rau qhov qub, kev txiav txim siab yuav tsum tau muab rau rov ua dua Rosulip lossis lwm qhov HMG-CoA reductase inhibitors nyob rau hauv qis dua nrog kev saib xyuas tus neeg mob. Kev soj ntsuam txhua lub sijhawm ntawm CPK cov haujlwm thaum tsis muaj cov tsos mob tsis tuaj yeem ua. Tsis muaj cov cim ntawm kev raug mob lom rau cov leeg pob txha thaum siv Rosulip ® ua ib feem ntawm kev sib xyaw ua ke. Kev nce ntxiv ntawm qhov tshwm sim ntawm myositis thiab myopathy tau tshaj tawm nyob rau hauv cov neeg mob noj lwm qhov HMG-CoA reductase inhibitors hauv kev sib xyaw nrog fibroic acid derivatives (suav nrog gemfibrozil), cyclosporine, nicotinic acid hauv lipid-txo cov tshuaj (ntau dua 1 g / hnub), azole antifungal tshuaj, inhibitors proteases thiab tshuaj tua kab mob los ntawm cov pab pawg macrolide. Gemfibrozil tsub kom muaj kev pheej hmoo ntawm myopathy thaum muab txuas ntxiv nrog qee yam HMG-CoA reductase inhibitors. Yog li, kev tswj hwm tib lub sij hawm ntawm cov tshuaj Rosulip ® thiab gemfibrozil tsis pom zoo. Qhov sib piv ntawm cov txiaj ntsig uas xav tau thiab qhov pheej hmoo muaj feem yuav tsum ua tib zoo ntsuas nrog kev siv cov tshuaj Rosulip ® thiab fibrates lossis nicotinic acid hauv lipid-txo cov koob tshuaj (ntau dua 1 g / hnub).

2-4 lub lis piam tom qab pib kho thiab / lossis nrog kev nce ntxiv ntawm Rosulip dose, kev saib xyuas cov lipid metabolism yog qhov tsim nyog (kev hloov tshuaj yog tsim nyog yog tias tsim nyog).

Nws raug nquahu kom txiav txim siab cov kev ua ntawm transaminases ua ntej pib kev kho thiab 3 lub hlis tom qab pib kho. Cov tshuaj Rosulip ® yuav tsum tau txiav txuas ntxiv lossis qhov tshuaj yuav tsum tau txo yog tias qhov kev ua haujlwm ntawm kev hloov pauv hauv cov ntshav cov ntshav yog siab dua 3 npaug ntawm VGN.

Hauv cov neeg mob hypercholesterolemia vim yog hypothyroidism lossis nephrotic syndrome, kev kho mob ntawm cov kabmob tseem ceeb yuav tsum tau nqa tawm ua ntej pib kho nrog Rosulip ®.

Cov kev soj ntsuam thiab cov ntaub ntawv hais txog kev siv tshuaj hauv cov neeg mob uas muaj lub siab ua tsis taus pa raug ntau dua li 9 tus menyuam yaus-Pugh cov qhab nia tsis muaj.

Feem ntau tsis tshua muaj mob ntawm cov mob ntsws interstitial tau qhia nyob rau hauv cov neeg mob kho nrog qee yam tshuaj statin. Feem ntau, cov mob no tau pom nrog kev kho statin ntev. Cov mob ntsws uas mob raum ua rau pom tseeb los ntawm kev ua pa luv, hnoos tsis txaus thiab ua rau muaj mob ntau ntxiv (nkees, poob ceeb thawj thiab kub ib ce). Yog tias xav tias tsam mob ntsws txawv ua ntej, kev kho mob statin yuav tsum tsis ua mus ntxiv.

Cov txiaj ntsig ntawm kev tshawb fawb pharmacokinetic qhia tau hais tias nyob hauv cov neeg mob ntawm haiv neeg Mooboid, kev noj zaubmov ntawm rosuvastatin muaj ntau dua li cov neeg sawv cev ntawm Caucasoid haiv neeg.

Rosulip ® yuav tsum tsis txhob noj rau cov neeg mob uas tsis haum lactose, lactase deficiency lossis glucose-galactose malabsorption, zoo li cov tshuaj muaj lactose.

Kev Siv Khomob

Qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj hauv cov menyuam yaus thiab hnub nyoog qis dua 18 xyoo tsis ntsia. Cov kev paub ntawm kev siv cov tshuaj hauv kev xyaum yug menyuam yog txwv rau qee tus menyuam yaus (txij li 8 xyoo thiab laus dua) nrog tsev neeg homozygous hypercholesterolemia. Tam sim no, Rosulip ® tsis pom zoo rau siv rau hauv cov menyuam yaus.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Cov neeg mob yuav tsum tau ceev faj thaum tsav tsheb lossis ua haujlwm, xav tau kom muaj kev saib xyuas ntau dua thiab nrawm ntawm cov tshuaj tiv thaiv psychomotor, vim tias kiv taub hau yuav tshwm sim thaum kho mob.

Yeeb tshuaj sib cuam tshuam

Cyclosporin: nrog kev siv rosuvastatin thiab cyclosporine tib lub sijhawm, AUC ntawm rosuvastatin tau nruab nrab 7 lub sijhawm siab dua li uas pom hauv cov neeg tuaj yeem noj qab haus huv. Kev siv tib lub sijhawm ua rau kev nce siab hauv rosuvastatin nyob rau hauv cov ntshav ntshav los ntawm 11 zaug, lub plasma qhov tseeb ntawm cyclosporine tsis hloov.

Antagonists K: pib ntawm rosuvastatin txoj kev kho lossis nce qhov ntau ntxiv rau hauv cov neeg mob uas tau txais ib txhij vitamin K antagonists (piv txwv li, warfarin) tuaj yeem ua rau nce sijhawm hauv prothrombin ntau dua thiab MHO. Kev tshem tawm cov rosuvastatin lossis txo nws cov koob tshuaj yuav ua rau MHO txo qis. Hauv cov xwm txheej zoo li no, MHO tswj hwm pom zoo.

Cov tshuaj Gemfibrozil thiab lipid-txo qis: kev siv sib xyaw ua ke ntawm rosuvastatin thiab gemfibrozil ua rau kev nce siab 2 zaug hauv C_max hauv ntshav ntshav thiab AUC ntawm rosuvastatin. Pharmacodynamic sis cuam tshuam muaj peev xwm ua tau. Gemfibrozil, lwm cov kab mob fibrates, thiab nicotinic acid hauv lipid-txo cov tshuaj (ntau dua 1 g / hnub) muaj kev pheej hmoo ntawm myopathy thaum siv nrog lwm HMG-CoA reductase inhibitors, tej zaum vim tias lawv tseem tuaj yeem ua rau myopathy thaum siv raws li tshuaj mob hlwb. Thaum noj cov tshuaj nrog gemfibrozil, fibrates, nicotinic acid hauv lipid-txo cov tshuaj (ntau dua 1 g / hnub), qhov pib koob tshuaj 5 mg yog pom zoo rau cov neeg mob. Kev Kho Mob nrog rosuvastatin ntawm ib koob ntawm 40 mg yog contraindicated nrog concomitant siv ntawm fibrates.

Ezetimibe: kev siv lub zog ib txhij Rosulip ® thiab ezetimibe tsis tau nrog kev hloov pauv hauv AUC thiab C_max ob qho tshuaj. Txawm li cas los xij, pharmacodynamic kev cuam tshuam nrog kev txhim kho cov kev mob tshwm sim tsis tuaj yeem txiav txim siab ntawm rosuvastatin thiab ezetimibe.

HIV tiv thaiv kab mob: txawm hais tias muaj pes tsawg qhov kev sib txuam ntawm kev sib cuam tshuam tsis tau paub, kev tswj hwm ntawm HIV tiv thaiv cov tshuaj tiv thaiv kab mob tuaj yeem ua rau muaj qhov nce ntxiv ntawm rosuvastatin. Kev tshawb fawb pharmacokinetic ntawm kev siv tib lub sijhawm 20 mg ntawm rosuvastatin nrog kev sib koom ua ke npaj muaj ob lub cev tiv thaiv kab mob (400 mg ntawm lopinavir / 100 mg ntawm ritonavir) hauv cov neeg tuaj yeem noj qab haus huv ua rau muaj kwv yees li ob-npaug thiab tsib-ntau qhov nce hauv AUC_(0-24) thiab C_max rosuvastatin, ntsig txog. Yog li, kev tswj hwm tib lub sijhawm ntawm rosuvastatin thiab protease inhibitors hauv kev kho mob rau tus neeg mob HIV tsis pom zoo.

Antacids: kev siv ib txhij ntawm rosuvastatin thiab antacid raug tshem tawm nrog aluminium thiab magnesium hydroxide ua rau txo qis ntshav ntawm rosuvastatin li 50%. Cov nyhuv no tsis tshua muaj suab yog tias raug tshem tawm ntawm antacids siv 2 teev tom qab noj rosuvastatin. Cov kab mob tseem ceeb ntawm qhov kev sib txuam no tsis tau kawm.

Erythromycin: tib lub sij hawm siv cov rosuvastatin thiab erythromycin ua rau txo qis AUC ntawm rosuvastatin los ntawm 20% thiab C_maxrosuvastatin los ntawm 30%, tej zaum yog los ntawm kev mob plab hnyuv ntxiv los ntawm kev noj erythromycin.

Kev kho mob qhov ncauj / tshuaj kho hloov kho (HRT):kev siv tib lub sijhawm rosuvastatin thiab tshuaj noj hauv qhov ncauj ua rau kom nce qhov AUC ntawm ethinyl estradiol thiab AUC ntawm norgestrel los ntawm 26% thiab 34%, feem. Xws li nce hauv plasma concentration yuav tsum tau coj mus rau hauv tus account thaum xaiv cov koob tshuaj tiv thaiv kab mob hauv qhov ncauj nrog Rosulip. Cov ntaub ntawv pharmacokinetic ntawm kev siv Rosulip thiab HRT tib txhij, yog li ntawd, cov txiaj ntsig zoo sib xws tsis tuaj yeem muab cais thaum siv sib xyaw no. Txawm li cas los xij, qhov kev sib txuam no tau siv dav dav thaum sim kho mob thiab tau txais txiaj ntsig zoo los ntawm cov neeg mob.

Lwm yam tshuaj: tsis muaj kev sib cuam tshuam hauv cov chaw kho mob ntawm rosuvastatin nrog digoxin yog qhov xav tau.

Isoenzymes ntawm cytochrome P450: hauv vivo thiab hauv kev tshawb fawb hauv vitro pom tau tias rosuvastatin tsis yog ib qho tshuaj thaiv qhov tsis yog qhov tsis zoo ntawm isoenzymes ntawm cytochrome P450 system. Tsis tas li ntawd, rosuvastatin yog cov neeg tsis muaj zog rau cov isoenzymes no. Tsis muaj kev cuam tshuam los ntawm kev kho mob tseem ceeb ntawm rosuvastatin thiab fluconazole (ib qho inhibitor ntawm isoenzymes CYP2C9 thiab CYP3A4) thiab ketoconazole (ib qho inhibitor ntawm isoenzymes CYP2A6 thiab CYP3A4). Kev siv sib xyaw ua ke ntawm rosuvastatin thiab itraconazole (ib qho inhibitor ntawm CYP3A4 isoenzyme) nce AUC ntawm rosuvastatin los ntawm 28% (tshuaj hauv tsev tsis tseem ceeb). Yog li, kev sib txuam cuam tshuam nrog cytochrome P450 system tsis xav.

Kev nyab xeeb ntawm kev noj tshuaj

Qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv cov tshuaj no los ntawm cov menyuam yaus tseem tsis tau tsim. Tsis muaj txheeb cais los kho cov menyuam yaus hnub nyoog qis dua 18 xyoo.

Rau cov neeg mob uas muaj hnub nyoog tshaj 70 xyoo, tus kws kho mob tau sau ntawv rau txoj kev siv tshuaj rau qhov tsawg kawg nkaus.

Rosulip ntxiv yuav tsum tsuas yog siv ua ke nrog lwm cov tshuaj.

Cov neeg mob uas tsis muaj teeb meem lub siab lub ntsws tsis tas yuav kho hloov qhov ntau npaum li cas. Hauv nruab nrab lub raum, qhov tshuaj yeeb tshuaj no tsuas siv tau yog tias siv lwm cov tshuaj tsis muaj txiaj ntsig tshwm sim.

Nrog kev ua txhaum me ntawm daim siab, kev hloov kho koob tshuaj yog tsis tsim nyog. Rosulip tsis pom zoo rau cov neeg mob uas muaj mob me me lossis mob hnyav hnyav hnyav, nrog rau mob hnyav.

Txoj kev ntawm daim ntawv thov

Rau cov neeg mob uas tsis tshua mob pes tsawg lub raum ua haujlwm (creatinine Cl tsawg dua 60 ml / min), kev pom zoo thawj zaug ntawm 5 mg yog kev pom zoo. Ib koob tshuaj ntawm 40 mg yog contraindicated rau hauv cov neeg mob uas muaj mob me hauv lub raum ua haujlwm. Thaum mob raum tsis ua haujlwm, Rosulip yog sib xyaw rau hauv ib koob tshuaj.
Thaum muab tshuaj ntawm 10 thiab 20 mg, koob tshuaj pom zoo thawj zaug rau cov neeg mob ntawm haiv neeg Asian yog 5 mg. Cov thawj coj ntawm cov tshuaj hauv ib koob tshuaj 40 mg yog contraindicated rau cov neeg mob ntawm cov haiv neeg Asian.
Thaum sau ntawv noj tshuaj ntawm 10 thiab 20 mg, qhov kev pom zoo thawj zaug rau cov neeg mob predisposed rau myopathy yog 5 mg. Kev tswj hwm ntawm cov tshuaj ntawm ib koob tshuaj 40 mg yog contraindicated rau hauv cov neeg mob uas muaj qee yam uas yuav qhia tau qhov kev xav ua ntej rau kev txhim kho ntawm myopathy.
Tom qab 2-4 lub lis piam ntawm kev kho mob thiab / lossis nrog kev nce ntxiv ntawm qhov tshuaj Rosulip, kev saib xyuas cov lipid metabolism yog qhov tsim nyog, thiab kev kho tshuaj yog tsim nyog yog tias tsim nyog.

Pharmacological pawg

Cov tshuaj uas txo cov roj (cholesterol) thiab triglycerides kom tsawg. HMG-CoA reductase inhibitors. ATX code C10A A07.

Thawj hypercholesterolemia (hom Pa, tsuas yog zam kev noj haus heterozygous hypercholesterolemia), los yog sib xyaw dyslipidemia (hom IIb) los ua kev noj haus, thaum cov txiaj ntsig ntawm kev noj zaub mov noj lossis lwm yam tsis muaj tshuaj (xws li kev tawm dag zog, poob phaus) tsis txaus.

Homozygous tsev neeg hypercholesterolemia yog ib qho kev txhawb ntxiv rau kev noj haus thiab lwm yam kev kho mob hypolipidemic (e.g. LDL apheresis), lossis thaum kho li ntawd tsis tsim nyog.

Kev Tiv Thaiv Mob Ntshav Siab

Rosulip ® yog qhia kom txo cov kev pheej hmoo loj ntawm cov hlab plawv hauv cov neeg mob cov neeg laus uas muaj kev pheej hmoo ntawm kev mob atherosclerotic kab mob plawv, raws li pom los ntawm qhov muaj kev pheej hmoo xws li lub hnub nyoog, mob ntshav nce hlwb, roj HDL tsawg, ua kom C-reactive protein ntau haus luam yeeb lossis tsev neeg muaj keeb kwm kev txhim kho mob plawv thaum ntxov.

Txhawm rau kom txo qis los yog ncua kev loj hlob ntawm tus kab mob hauv cov neeg mob uas pom tias cov lipid-txo cov tshuaj.

Menyuam yaus thiab tub ntxhais hluas (txij li 10 txog 17 xyoos: cov tub hluas - theem II nrog tus qauv Tanner thiab siab dua, cov menyuam ntxhais - tsawg kawg li ib xyoos tom qab thawj zaug poj niam).

Kev kho mob ntawm thawj hypercholesterolemia (hom Pa) lossis sib xyaw dyslipidemia (hom IIb) vim los ntawm heterozygous tsev neeg hypercholesterolemia ntxiv rau kev noj zaub mov, thaum lub txiaj ntsig ntawm kev noj haus lossis lwm txoj kev siv tshuaj tsis zoo (xws li qoj ib ce, poob phaus) tsis txaus.

Kev phiv tshuaj

Cov kev tsis zoo tshwm sim pom nrog Rosulipu ® feem ntau yog me me thiab hloov dhau mus.

Los ntawm lub cev tiv thaiv kab mob : Kev tsis haum tshuaj qhov tsis haum, suav nrog angioedema.

Los ntawm cov kab ke endocrine: mob ntshav qab zib mellitus.

Los ntawm lub paj hlwb tawg : mob taub hau, kiv taub hau.

Los ntawm cov mob hauv plab zom mov : cem quav, xeev siab, mob plab, pancreatitis.

Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: khaus, tawm pob, thiab ua xua.

Los ntawm cov leeg musculoskeletal, sib txuas cov nqaij thiab pob txha : mob myalgia myopathy (suav nrog myositis) thiab mob rhabdomyolysis.

General mob: asthenia.

Ib yam li lwm yam HMG-CoA reductase inhibitors, qhov nquag tshwm sim ntawm qhov tsis haum yog koob tshuaj.

Ua rau lub raum

Hauv cov neeg mob uas tau txais Rosulip ®, muaj cov xwm txheej ntawm proteinuria, feem ntau ntawm cov tubular keeb kwm (txiav txim siab siv ntsuas kab xev).

Ntxim rau cov leeg pob txha

Ntawm ib feem ntawm cov leeg pob txha, xws li myalgia, myopathy (suav nrog myositis) thiab tsis tshua muaj mob rhabdomyolysis nrog lossis tsis mob raum tsis ua haujlwm, tau pom nrog ib koob tshuaj Rosulipu ®, tshwj xeeb tshaj yog nrog koob tshuaj> 20 mg. Cov mob tsis tshua muaj mob rhabdomyolysis, qee zaum cuam tshuam nrog lub raum tsis ua haujlwm, tau tshaj tawm nrog rosuvastatin thiab lwm yam statins.

Hauv cov neeg mob noj cov tshuaj rosuvastatin, qhov tshuaj tiv thaiv ntau ntxiv hauv CPK (CPK) qib siab tau pom; feem ntau, qhov tshwm sim tsis muaj zog, tsis muaj asymptomatic thiab ib ntus. Yog tias qib CK nce siab (> 5 ntawm qhov tsis pub tshaj ntawm qhov qub (BMN)), kev kho yuav tsum tsis ua mus ntxiv.

Ua rau daim siab

Ib yam li lwm yam HMG-CoA reductase inhibitors, qee tus neeg mob tsawg noj rosuvastatin pom tias muaj kev noj tshuaj ntau ntxiv hauv transaminases, feem ntau qhov tshwm sim me, asymptomatic thiab ib ntus.

Cawv rau ntawm kev ntsuas ntsuas

Ib yam li lwm yam HMG-CoA reductase inhibitors, feem tsawg ntawm cov neeg mob noj rosuvastatin tau txais koob tshuaj ntau-ntau hauv theem ntawm hepatic transaminases thiab CPK.

Thaum lub sij hawm soj ntsuam mob mus ntev ntev, Rosulip ® tsis qhia qhov cuam tshuam rau tus neeg mob tus mob; nws siv tsom iav.

Hauv cov neeg mob noj Rosulip ®, tsis muaj kev ua kom tsis muaj mob ntawm adrenal cortex.

Kev Kev Lag Luam Tom Qab Kev Lag Luam

Ntxiv rau qhov tau hais tseg, nyob rau lub sijhawm tom qab lub sijhawm thov kev thov ntawm Rosulipu ® cov xwm txheej hauv qab no tau sau cia.

Los ntawm lub paj hlwb: polyneuropathy, nco ploj.

Los ntawm lub tshuab ua pa, hauv siab thiab mediastinal kabmob: hnoos, txog siav.

Los ntawm lub plab zom mov: zawv plab

Los ntawm lub plab zom mov: daj ntseg, kab mob siab ua si rau hepatic transaminases.

Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: Stevens-Johnson mob.

Los ntawm cov leeg musculoskeletal: txhaj tshuaj tiv thaiv-mediated necrotizing myopathy, mob caj dab.

Los ntawm ob lub raum: hematuria.

General mob thiab kev cuam tshuam cuam tshuam nrog txoj kev ntawm kev siv tshuaj: o tuaj.

Los ntawm kev muaj me nyuam thiab qog mammary qog: gynecomastia.

Ntshav: thrombocytopenia.

Thaum siv qee yam statins, cov kev mob tshwm sim hauv qab no tau tshaj tawm:

kev nyuaj siab
pw tsaug zog, suav nrog insomnia thiab npau suav phem,
deev kawg,
ib tug neeg mob interstitial mob ntsws, tshwj xeeb tshaj yog muaj kev kho mob ntev,
mob leeg, qee zaum nyuaj los ntawm lawv kev sib tawg.

Kev tshwm sim ntawm rhabdomyolysis, mob raum thiab mob siab hnyav (feem ntau yog nce qib ntawm transaminases) tau siab dua nrog ib koob ntawm 40 mg.

Cov menyuam yaus hnub nyoog 10 txog 17 xyoo

Cov ntaub ntawv kev nyab xeeb ntawm Rosulipu ® rau cov menyuam yaus thiab cov neeg laus yog qhov zoo sib xws. Txawm li cas los xij, rau menyuam yaus thiab cov neeg laus, kev ceev faj siv cov Rosulipu ® yog qhov qub.

Siv thaum cev xeeb tub thiab lactation

Muaj kev nyab xeeb ntawm Rosulipu ® thaum cev xeeb tub thiab lactation tsis tau kawm.

Rosulip ® yog contraindicated thaum cev xeeb tub thiab lactation.

Cov poj niam ntawm kev muaj me nyuam thaum muaj hnub nyoog thaum noj cov tshuaj Rosulipu use yuav tsum siv kev tswj kom tsis txhob muaj me nyuam.

Txij li cov roj (cholesterol) thiab cov roj (cholesterol) biosynthesis tseem ceeb yog qhov tseem ceeb rau kev loj hlob ntawm menyuam, qhov kev pheej hmoo ntawm kev ua kom tsis haum HMG-CoA reductase ntau dhau cov txiaj ntsig zoo ntawm kev siv cov tshuaj thaum cev xeeb tub. Yog tias tus neeg mob tau cev xeeb tub thaum lub sijhawm siv cov tshuaj, kev kho mob yuav tsum nres tam sim ntawd.

Tsis pom zoo siv Rosulipu ® rau cov me nyuam qis dua 10 xyoo tsis pom zoo.

Qhov tshwm sim ntawm rosuvastatin ntawm txoj kab kev loj hlob (kev loj hlob), lub cev nyhav, BMI (lub cev qhov ntsuas) thiab kev loj hlob ntawm cov yam ntxwv ntawm kev sib deev theem ob ntawm Tanner nplai thaum hnub nyoog 10-17 xyoo tau soj ntsuam tsuas yog rau ib xyoos. Tom qab 52 lub lim tiam ntawm kev siv cov tshuaj tshawb, tsis muaj kev cuam tshuam rau qhov siab, lub cev nyhav, BMI lossis kev sib deev tau pom.

Cov yam ntxwv ntawm daim ntawv thov. Ua rau lub raum

Hauv cov neeg mob uas tau txais Rosulip ® hauv cov koob tshuaj siab, tshwj xeeb tshaj yog 40 mg, muaj cov xwm txheej ntawm cov proteinuria (txiav txim siab siv tshuaj ntsuas), feem ntau ntawm tubular keeb kwm thiab, feem ntau, ib ntus. Proteinuria tsis tau qhia tias muaj mob raum lossis mob raum. Cov xwm txheej tsis zoo los ntawm lub raum hauv lub sijhawm tom qab lub sijhawm muag khoom tau sau tseg ntau zaus nrog ib koob ntawm 40 mg.

Ntxim rau cov leeg pob txha

Cov leeg nqaij pob txha raug mob, xws li myalgia, myopathy, thiab tsis tshua muaj rhabdomyolysis tau pom nyob hauv cov neeg mob uas muaj txhua yam tshuaj ntawm Rosulip ®, tshwj xeeb tshaj yog ntawm cov koob tshuaj ntau dua 20 mg. Thaum siv ezetimibe hauv kev sib xyaw nrog HMG-CoA reductase inhibitors, tus mob ntawm rhabdomyolysis tau hais tawm tsis tshua pom muaj. Qhov tau ntawm kev sib txuam pharmacodynamic tsis tuaj yeem txiav tawm, thiab yog li kev sib xyaw no yuav tsum siv nrog ceev faj.

Raws li nrog kev siv lwm yam HMG-CoA reductase inhibitors, cov mob ntawm rhabdomyolysis cuam tshuam nrog kev siv Rosulipu ® nyob rau lub sijhawm kev tshaj tawm tom qab tau pom ntau dua nrog ib koob ntawm 40 mg. Muaj cov ntawv tshaj tawm txog qee qhov mob uas tsis muaj kev tiv thaiv kab mob rau lub cev ua kom tsis txhob myopathy, qhov chaw kuaj mob pom los ntawm cov leeg tsis muaj zog thiab ua kom muaj qib ntau ntau ntawm CPK thaum kho lossis tom qab kho nrog statins, suav nrog rosuvastatin. Hauv qhov no, kev tshawb nrhiav neuromuscular ntxiv thiab serological, kev kho mob nrog cov tshuaj tiv thaiv kab mob tej zaum yuav tsum tau.

Kev txiav txim siab txog qib uas yog CPK

Qib theem ntawm CPK yuav tsum tsis txhob ntsuas tom qab kev tawm dag zog lub cev lossis muaj qhov pom tau lwm qhov laj thawj rau qhov nce hauv CPK, uas yuav cuam tshuam nrog kev txhais lus ntawm cov txiaj ntsig. Yog tias qib pib ntawm CPK tau nce siab heev (> 5 ntawm qhov txwv ntawm qhov tseem ceeb), ib qho kev tshuaj xyuas kev lees paub ntxiv yuav tsum tau ua hauv 5-7 hnub. Yog tias qhov tshwm sim ntawm kev ntsuas rov qab lees tias qhov pib theem> 5 los ntawm qhov siab ntawm qhov txwv, kev kho yuav tsum tsis txhob pib.

Rosulip ®, zoo li lwm yam tshuaj tiv thaiv ntawm HMG-CoA reductase, yuav tsum tau siv nrog kev ceev faj hauv cov neeg mob uas muaj feem cuam tshuam nrog kev txhim kho myopathy / rhabdomyolysis. Tej yam no suav nrog:

tsis hnov mob raum muaj nuj nqi
hypothyroidism
muaj nyob rau hauv tus kheej los yog tsev neeg keeb kwm muaj keeb kab mob leeg,
keeb kwm ntawm myotoxicity tshwm sim los ntawm lwm HMG-CoA reductase inhibitors lossis fibrates,
haus cawv
hnub nyoog> 70 xyoo
cov xwm txheej uas tuaj yeem ua rau nce qib ntawm cov tshuaj hauv plasma,
tib lub sij hawm siv cov fibrates.

Rau cov neeg mob zoo li no, nws yog ib qho tsim nyog los sib piv txoj kev pheej hmoo thiab muaj txiaj ntsig thaum siv tshuaj, kev tshuaj xyuas mob kuj tseem pom zoo.

Thaum kho

Cov neeg mob yuav tsum tau txais kev ceeb toom ntawm qhov yuav tsum tau ceeb toom tam sim uas tsis tau piav qhia ntawm cov leeg mob, leeg tsis muaj zog, los yog mob plab, tshwj xeeb tshaj yog tias lawv nrog tus mob malaise lossis kub taub hau. Hauv cov neeg mob no, qib qib CPK yuav tsum tau txiav txim siab. Nws yog qhov yuav tsum tau txiav tawm kev kho mob yog tias qib ntawm CPK tau nce siab (> 5 ntawm VMN) lossis yog tias cov leeg mob hnyav heev thiab ua rau tsis xis nyob hauv lub neej txhua hnub (txawm tias qib ntawm CPK ≤ 5 los ntawm VMN). Yog tias cov tsos mob ploj thiab qib qib CPK rov qab zoo li qub, Rosulip ® lossis lwm txoj kev tiv thaiv tshuaj ntawm HMG-CoA reductase tuaj yeem rov sim dua, tab sis tsawg kawg koob tshuaj thiab kev saib xyuas ze. Kev soj ntsuam tsis tu ncua ntawm qib CPK hauv cov neeg mob uas tsis muaj cov tsos mob saum toj no tsis tas yuav xav tau.

Txawm li cas los xij, muaj kev cuam tshuam ntawm myositis thiab myopathy tau pom nyob rau hauv cov neeg mob siv lwm HMG-CoA reductase inhibitors nrog fibroic acid derivatives, suav nrog gemfibrozil, cyclosporin, nicotinic acid, azole antifungal agents, protease inhibitors thiab tshuaj tua kab mob macrolide. Gemfibrozil tsub kom muaj kev pheej hmoo ntawm myopathy thaum nws siv nrog qee qhov HMG-CoA reductase inhibitors, yog li Rosulip ® tsis pom zoo rau siv ua ke nrog gemfibrozil. Qhov txiaj ntsig zoo ntawm kev hloov pauv ntxiv nyob rau qib lipid nrog kev siv Rosulipu ® nrog tib leeg nrog fibrates lossis niacin yuav tsum muab piv nrog cov kev pheej hmoo thaum siv cov kev sib txuam no. Kev siv ib txhij ntawm Rosulipu® ntawm ib koob ntawm 40 mg thiab fibrates yog contraindicated.

Rosulip ® yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj feem ua rau kev txhim kho myopathy, xws li lub raum tsis ua haujlwm, lub hnub nyoog nce, hypothyroidism, lossis hauv cov xwm txheej uas cov tshuaj yeeb hauv plasma tuaj yeem nce ntxiv.

Rosulip ® yuav tsum tsis txhob siv rau cov neeg mob uas muaj mob hnyav, mob hnyav uas ua rau muaj kev txhim kho myopathy lossis nce kev pheej hmoo ntawm kev tsim muaj lub raum tsis ua haujlwm vim mob rhabdomyolysis (xws li mob sepsis, mob ntshav siab, kev phais mob loj, mob, mob hnyav ntawm lub cev, endocrine lossis electrolyte cuam tshuam thiab kev tswj tsis tau tus mob).

Ua rau daim siab

Zoo li lwm yam HMG-CoA reductase inhibitors, Rosulip ® yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj keeb kwm ntawm cawv thiab / lossis mob siab.

Nws raug nquahu kom kuaj xyuas lub siab ua haujlwm ua ntej pib kev siv tshuaj thiab tom qab 3 lub hlis kho. Yog tias theem ntawm kev hloov ntshav hauv cov ntshav cov ntshav ntau tshaj peb zaug tshaj qhov txwv tsis pub dhau ntawm ib txwm, kev siv Rosulip yuav tsum tsis ua mus ntxiv. Cov teeb meem mob siab rau lub siab (feem ntau yog nce ntawm hepatic transaminases) hauv kev tshaj tawm tom qab lub sijhawm tau tshaj tawm ntau dua nrog cov koob tshuaj 40 mg.

Hauv cov neeg mob uas muaj tus mob hypercholesterolemia tshwm sim los ntawm hypothyroidism lossis nephrotic syndrome, kev kho mob ntawm lwm tus kab mob yuav tsum tau nqa tawm ua ntej, thiab tom qab ntawd kev siv Rosulipu ® yuav tsum tau pib.

Hauv kev tshawb fawb ntawm cov tshuaj pharmacokinetics, kev nce ntxiv hauv cov neeg muaj kab mob tau pom nyob hauv cov neeg mob ntawm haiv neeg Mongoloid piv nrog cov sawv cev ntawm cov haiv neeg European.

Kev siv ua ke tib lub sijhawm nrog cov tshuaj tiv thaiv protease inhibitors tsis pom zoo.

Cov neeg mob uas tsis tshua muaj kab mob galactose tsis txaus, Lapp lactase deficiency lossis glucose-galactose malabsorption yuav tsum tsis txhob siv cov tshuaj no.

Cov mob ntsws interstitial

Cais tawm tus neeg mob ntsws interstitial mob ntsws tau qhia nrog qee yam statins, tshwj xeeb tshaj yog hais txog kev kho mob ntev. Cov tsos mob ntawm tus mob muaj xws li ua tsis taus pa, tsis hnoos tsis tu ncua, thiab ua rau cov neeg mob haj yam mob (nkees, poob ceeb thawj, thiab kub ib ce). Yog tias tus neeg mob xav tias muaj tus kab mob ntsws interstitial ntsws, kev siv cov statins yuav tsum tsis ua mus ntxiv.

Ib yam li lwm HMG-CoA reductase inhibitors, kev nce HbA1c thiab ntshav qabzib ntau tau pom nrog rosuvastatin. Muaj qee kis, cov ntsuas no yuav dhau qhov txwv rau kev kuaj mob ntshav qab zib, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kev pheej hmoo siab mob ntshav qab zib.

Cov menyuam yaus hnub nyoog 10 txog 17 xyoo

Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem

Ib qho kev kawm txog cov nyhuv ntawm rosuvastatin ntawm kev muaj peev xwm tsav tsheb los yog ua haujlwm nrog lwm cov txheej txheem tsis tau coj los ua.

Txawm li cas los xij, muab nws cov khoom lag luam pharmacodynamic, nws tsis zoo li Rosulip affect tuaj yeem cuam tshuam cov tshuaj tiv thaiv thaum tsav tsheb lossis ua haujlwm nrog lwm cov txheej txheem. Txawm li cas los xij, nws yuav tsum tau yug hauv lub siab tias kiv taub hau yuav tshwm sim thaum kho.

Cov lus qhia rau kev siv Rosulip: txoj kev thiab ntau npaum li cas

Rosulip tau noj ntawm qhov ncauj. Cov ntsiav tshuaj yuav tsum nqos tag nrho, tsis tas yuav zom thiab zom, thiab ntxuav nrog dej. Ib tug lipid-qis tus neeg sawv cev tuaj yeem nqa thaum lub sijhawm nruab hnub, tsis hais txog ntawm cov khoom noj.

Ua ntej noj cov tshuaj, tus neeg mob yuav tsum hloov mus rau kev noj zaub mov kom zoo nrog cov ntsiab lus ntawm Chs tsawg, uas nws yuav tsum tau ua raws li thoob plaws hauv chav kawm. Tus kws kho mob xaiv cov koob tshuaj rosuvastatin ua ib leeg zuj zus, nyob ntawm qhov ntsuas thiab kev kho mob, nrog rau kev suav nrog cov lus pom zoo tam sim no ntawm cov qib lipid.

Cov neeg mob uas tsis tau txais cov tshuaj statins yav dhau los lossis hloov mus los ntawm kev noj lwm yam HMG-CoA reductase inhibitors yuav tsum hais kom noj Rosulip 1 zaug nyob rau ib hnub rau thawj zaug ntawm 5 lossis 10 mg. Kev xaiv ntawm cov tshuaj tiv thaiv thawj zaug yuav tsum tau ua, coj los ntawm cov tib neeg theem ntawm cov roj cholesterol thiab coj mus rau hauv tus account qhov kev txhim kho ntawm cov kev mob plawv, nrog rau cov kev pheej hmoo ntawm cov teebmeem tsis xav tau.

Yog tias tsim nyog, nce lub koob 4 lub lis piam tom qab pib kev kawm. Tom qab noj ib koob tshuaj nyob rau hauv ntau tshaj ntawm thawj zaug koob tshuaj rau 4 lub lis piam, nws nce ntxiv mus rau 40 mg yog tso cai tsuas yog muaj mob hypercholesterolemia loj thiab qhov kev tsis txaus siab ntawm kev pheej hmoo ntawm cov hlab plawv mob (feem ntau hauv cov neeg mob nrog tsev neeg hypercholesterolemia) nyob rau hauv rooj plaub thaum nws tsis tuaj yeem ua tiav qhov xav tau thaum siv koob tshuaj ntawm 20 mg. Nyob rau lub sijhawm ntawm cov tshuaj no nce ntxiv, nrog rau kev tswj hwm tom ntej ntawm Rosulip ntawm ib koob ntawm 40 mg, cov neeg mob yuav tsum tau nyob hauv kev saib xyuas ntawm tus kws tshaj lij.

Cov neeg predisposed rau myopathy, thaum sau tshuaj rau ntawm 10 thiab 20 mg, nws raug pom zoo kom noj Rosulip hauv thawj zaug pib ntawm 5 mg. Nyob rau hauv lub xub ntiag ntawm cov ntsiab lus taw qhia ib tug nyiam mus rau kev tshwm sim ntawm myopathy, lub sij hawm teem ntawm cov tshuaj nyob rau hauv ib koob ntawm 40 mg yog contraindicated.

Hauv cov neeg mob uas muaj teeb meem me me ntawm lub raum (CC tsawg dua 60 ml / min), qhov pib ntawm Rosulip yuav tsum yog 5 mg.

Thawj koob tshuaj rau cov neeg laus (laus dua 65) yog 5 mg.

Cov sawv cev ntawm haiv neeg Mongoloid, cov koob tshuaj rosulip hauv ib koob 40 mg yog contraindicated, thaum siv 10 mg thiab 20 mg ntsiav tshuaj, nws raug nquahu kom pib noj cov tshuaj 5 mg.

Tom qab 2-4 lub lim tiam ntawm kev kho mob thiab / lossis tiv thaiv keeb kwm ntawm qhov nce ntxiv ntawm qhov koob tshuaj, nws yog ib qho tsim nyog los soj ntsuam cov lipid metabolism, thiab yog tias tsim nyog, kho qhov koob tshuaj.

Sab sij huam

Cov kev ua txhaum tau sau tseg thaum kho nrog Rosulip feem ntau yog mob me thiab ntev. Qhov ntau zaus ntawm cov kev mob tshwm sim los ntawm kev noj rosuvastatin yog noj cov tshuaj.

musculoskeletal system: feem ntau - myalgia, tsis tshua muaj - myopathy (suav nrog myositis) thiab rhabdomyolysis nrog txoj kev loj hlob ntawm cov mob raum tsis zoo los yog tsis muaj nws, nrog ib qho tsis paub zaus - kev tiv thaiv-tiv thaiv necrotizing myopathy, koob tshuaj nce ntxiv nyob rau theem ntawm creatine phosphokinase (CPK) (pom hauv ib qho me me tus naj npawb ntawm cov neeg mob, feem ntau tsis muaj asymptomatic, tsis tseem ceeb thiab ib ntus), tsis tshua muaj tshwm sim - arthralgia,
kev kho mob plab zom mov: feem ntau - mob plab, xeev siab, quav tawv, tso tsis tau - hloov chaw, asymptomatic, nce me ntsis hauv kev ua haujlwm ntawm hepatic transaminases, tsis tshua muaj - kab mob pancreatitis, tsis tshua muaj mob - kab mob siab, daj ntseg, nrog tus tsis paub ntau zaus - raws plab,
cov kab mob hauv lub paj hlwb: feem ntau - kiv taub hau, mob taub hau, tsis tshua muaj tshwm sim - nco ploj / ploj, polyneuropathy,
kev tiv thaiv kab mob: tsis tshua muaj - kev ua kom tsis haum mob (suav nrog angioneurotic edema),
cov tawv nqaij thiab cov kab mob tsis xws luag: txau dhau - ua pob, ua pob, mob pob, tso zis, nrog tsis paub ntau zaus - Stevens-Johnson syndrome,
tus kab mob ua pa: ntau zaus uas tsis paub - ua tsis taus pa, hnoos,
cov kab mob tso zis: proteinuria (thaum tau txais koob tshuaj 10-20 mg - tsawg dua 1% ntawm cov neeg mob, thaum tau txais koob tshuaj 40 mg - txog 3%), uas feem ntau poob qis lossis ploj thaum kho thiab tsis txhais tau tias kev loj hlob ntawm cov mob raum lossis kev txom nyem ntawm cov kab mob hauv lub raum uas twb muaj lawm tsis tshua muaj - hematuria,
lwm tus: feem ntau - asthenic syndrome, tsis tshua muaj tshwm sim - gynecomastia, nrog qhov tsis paub ntau zaus - kev ua haujlwm ntawm lub qog ua haujlwm,
cov cim ntsuas: tsis tshua muaj - thrombocytopenia, nrog qhov tsis paub tseeb - hyperglycemia, ntau ntau ntawm bilirubin, glycosylated hemoglobin, kev ua si ntawm alkaline phosphatase, gamma glutamyl transpeptidase.

Thaum kho nrog qee yam statins, cov kev xav tsis zoo hauv qab no kuj tseem tau sau cia: nrog qhov tsis paub meej - pw tsaug zog (suav nrog kev npau suav phem thiab pw tsis tsaug zog), kev nyuaj siab, kev sib daj sib deev, raug mob raug rho tawm - mob ntsws interstitial (tshwj xeeb nrog siv ntev).

Cev xeeb tub thiab lactation

Thaum cev xeeb tub thiab thaum pub mis niam, kev siv Rosulip yog contraindicated.

Yog tias kuaj pom lub cev thaum muaj kev kho mob, cov tshuaj yuav tsum nres tam sim ntawd. Cov pojniam ntawm lub hnub nyoog yug menyuam yuav tsum tau siv kev tswj kom tsis muaj menyuam thaum lub sijhawm kho. Vim yog qhov tseeb tias Chs thiab nws cov khoom lag luam biosynthesis yog qhov tseem ceeb rau kev loj hlob ntawm tus me nyuam hauv plab, kev pheej hmoo txaus ntshai ntawm kev thaiv in HMG-CoA reductase ntau tshaj cov txiaj ntsig ntawm kev kho tshuaj.

Cov poj niam uas xav siv Rosulip thaum lactation yuav tsum tsis txhob pub mis, vim tias tsis muaj ntaub ntawv qhia txog kev faib cov rosuvastatin nrog rau niam mis.

Siv rau thaum yau

Hauv cov menyuam yaus ntawm cov menyuam yaus, qhov kev ua haujlwm thiab kev nyab xeeb ntawm Rosulip tsis muaj pov thawj. Cov kev paub ntawm kev siv rosuvastatin rau pawg neeg mob no tsuas yog txwv rau qee tus neeg mob hnub nyoog 8 xyoo thiab laus dua nrog homozygous daim ntawv ntawm kev tiv thaiv kab mob hypercholesterolemia.

Cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo yuav tsum tsis txhob haus cov tshuaj no.

Thaum tsis ua haujlwm lub raum

Nyob rau hauv qhov muaj qhov hnyav ntawm lub raum tsis ua haujlwm (CC tsawg dua 30 ml / min), kev siv Rosulip hauv ib koob tshuaj yog contraindicated.

40 mg ntsiav tshuaj yog contraindicated nyob rau hauv muaj mob pesnrab ntawm lub raum tsis ua hauj lwm (CC tsawg dua 60 ml / min), nrog rau mob hnyav - yuav tsum tau siv nrog ceev faj.

Cov ntsiav tshuaj ntawm 10 thiab 20 mg rau lub raum tsis ua haujlwm yuav tsum tau ua nrog ceev faj. Rau cov neeg mob uas muaj teeb meem tsis haum lub raum (CC tsawg dua 60 ml / min), qhov pib ntawm Rosulip yuav tsum yog 5 mg.

Nrog lub siab ua haujlwm tsis zoo

Raws li cov lus qhia, Rosulip yog contraindicated nyob rau hauv lub xub ntiag ntawm ib tug active theem ntawm tus kab mob mob siab, nrog rau nrog tsis tu ncua nce nyob rau hauv lub ntshiab kev ua ub no ntawm transaminases thiab tej kev nce nyob rau hauv lawv cov kev ua si tshaj VGN los ntawm ntau tshaj 3 zaug. Yog tias muaj keeb kwm muaj kab mob siab, cov tshuaj yuav tsum siv nrog ceev faj.

Kev txheeb xyuas ntawm Rosulip

Raws li kev kuaj xyuas ob peb, Rosulip ua haujlwm txo qis kom muaj cov roj cholesterol hauv cov ntshav, txo qis txoj kev pheej hmoo ntawm kev tsim mob atherosclerosis thiab cov hlab plawv tsis zoo. Txawm li cas los xij, txhawm rau kom ua tiav cov txiaj ntsig kev kho mob zoo, cov neeg mob uas tau txais cov tshuaj kuj pom zoo kom tswj cov qib kev ua si kom tsim nyog thiab nco ntsoov ua raws li kev noj haus zoo.

Qhov tsis zoo ntawm cov tshuaj tiv thaiv hypolipidemic muaj ntau daim ntawv teev cov kev tiv thaiv thiab tsim kev phiv, feem ntau xeev siab thiab kub siab. Kuj, ntau tus neeg mob yws txog qhov pheej yig dua ntawm Rosulip.