Cov lus qhia ntawm Metfogamma 1000 rau kev siv, contraindications, phiv, tshuaj xyuas

Thoob ntiaj teb lub npe:Metfogamma 1000

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov ntsiav tshuaj, coated nrog cov xim zaj duab xis txheej, yog oblong, nrog kev pheej hmoo, nrog yuav luag tsis muaj ntxhiab tsw. 1 ntsiav tshuaj muaj 1000 mg ntawm meformin hydrochloride. Tshwjxeeb: hypromellose (15000 CPS) - 35,2 mg, povidone (K25) - 53 mg, magnesium stearate - 5.8 mg.

Muaj pes tsawg leeg plhaub: hypromellose (5 CPS) - 11,5 mg, macrogol 6000 - 2.3 mg, titanium dioxide - 9,2 mg.

Hauv hlwv 30 lossis 120 ntsiav tshuaj. Ntim rau hauv thawv ntawv thawv.

Cov chaw soj ntsuam thiab chaw muag tshuaj

Tshuaj qhov ncauj hypoglycemic

Cov tshuaj pab pawg kho mob

Hypoglycemic tus neeg sawv cev rau kev tswj hwm qhov ncauj ntawm cov pab pawg biguanide

Pharmacological kev txiav txim ntawm cov tshuaj Metfogamma 1000

Qhov ncauj tshuaj hypoglycemic los ntawm cov pab pawg biguanide. Nws inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm txoj hnyuv, txhim kho kev siv ntawm cov kua nplaum ntev, thiab tseem ua rau kev nkag siab ntawm cov ntaub so ntswg mus rau insulin. Nws tsis cuam tshuam qhov zais cia ntawm insulin los ntawm β-hlwb ntawm tus txiav.

Lowers triglycerides, LDL.

Stabilizes lossis txo qhov hnyav lub cev.

Nws muaj cov nyhuv fibrinolytic vim yog kev tsuj tawm ntawm cov nqaij plasminogen activator inhibitor.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, metformin yog nqus los ntawm cov hnyuv. Bioavailability tom qab noj cov qauv tshuaj yog 50-60%. C max tom qab kev tswj hwm ntawm qhov ncauj tiav tom qab 2 teev

Nws xyaum tsis khi rau cov plasma protein. Nws accumulates nyob rau hauv salivary qog, nqaij, mob siab, thiab ob lub raum.

Nws tawm hauv cov zis tsis hloov pauv. T 1/2 yog 1.5-4.5 teev.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Nrog kev ua haujlwm tsis zoo hauv lub raum, tsub zuj zuj ntawm cov tshuaj yog ua tau.

Yam 2 ntshav qab zib mellitus (non-insulin-dependant) yam tsis muaj ketoacidosis (tshwj xeeb tshaj yog rau cov neeg mob rog rog) nrog kev noj zaub mov zoo tsis muaj txiaj ntsig.

Cov Yuav Tsum Muaj

Kev kub siab tsis txaus, hyperglycemic coma, ketoacidosis, mob raum tsis ua haujlwm, mob siab, tsis ua haujlwm, muaj mob myocardial infarction, ua pa tsis ua haujlwm, lub cev qhuav dej, kis kab mob, ua haujlwm ntau thiab raug mob, haus dej cawv, kev noj zaub mov kom tsawg (tsawg dua 1000 kcal / hnub), lactic acidosis (suav nrog keeb kwm), cev xeeb tub, lactation. Cov tshuaj tsis raug xa tawm 2 hnub ua ntej kev phais mob, radioisotope, kev tshawb nrhiav xoo hluav taws xob nrog kev qhia ntawm cov tshuaj sib luag thiab tsis pub dhau 2 hnub tom qab lawv siv nrog kev ceev faj. Tshaj 60 xyoo hnub nyoog, ua haujlwm lub cev hnyav (nce kev pheej hmoo ntawm kev tsim mob lactic acidosis hauv lawv).

Dosage regimen thiab cov qauv ntawm daim ntawv thov Metfogamma 1000

Teeb ntawm tus kheej, noj mus rau hauv tus account theem ntawm cov piam thaj hauv cov ntshav.

Qhov kev txhaj tshuaj thawj zaug feem ntau yog 500 mg-1000 mg (1 / 2-1 tab.) / Hnub. Ib qho kev nce zuj zus ntxiv hauv koob tshuaj yog muaj peev xwm ua raws li cov txiaj ntsig ntawm kev kho mob.

Kev saib xyuas qhov koob tshuaj yog 1-2 g (1-2 ntsiav tshuaj) / hnub. Qhov tshuaj tiv thaiv ntau tshaj plaws txhua hnub yog 3 g (3 ntsiav tshuaj). Lub hom phiaj ntawm cov tshuaj nyob rau hauv cov koob tshuaj ntau dua tsis ua rau cov nyhuv ntawm txoj kev kho.

Cov ntsiav tshuaj yuav tsum tau noj nrog zaub mov noj kom tag nrho, ntxuav cia nrog me me ntawm cov kua (ib khob dej).

Cov tshuaj yog npaj rau kev siv sijhawm ntev.

Vim tias qhov pheej hmoo ntawm cov kab mob lactic acidosis, nyob rau hauv cov teeb meem hauv lub cev hnyav ntawm lub cev, cov tshuaj yuav tsum raug txo kom tsawg.

Sab sij huam

Los ntawm lub plab zom mov: xeev siab, ntuav, mob plab, zawv plab, tsis qab los noj mov, nws yog xim hlau hauv lub qhov ncauj (raws li txoj cai, tsis kho kev kho mob tsis tas, thiab cov tsos mob ploj mus lawv tus kheej tsis tas hloov cov koob tshuaj, qhov ntau zaus thiab qhov mob ntawm cov kev mob tshwm sim tuaj yeem txo nrog qhov nce ntawm koob tshuaj metformin), tsis tshua muaj - pathological deviations ntawm kev kuaj mob siab, kab mob siab (dhau tom qab tshem tawm yeeb tshuaj).

Kev tsis haum tshuaj: daim tawv nqaij ua pob.

Los ntawm cov kab ke endocrine: hypoglycemia (thaum siv hauv cov koob tshuaj tsis tsim nyog).

Los ntawm sab ntawm cov metabolism: tsis tshua muaj - lactic acidosis (yuav tsum muaj kev kho mob ncua ntev), nrog kev siv ntev - hypovitaminosis B₁₂ (malabsorption).

Los ntawm cov kab ke hemopoietic: hauv qee kis - megaloblastic anemia.

Cev xeeb tub thiab lactation

Cov tshuaj yog contraindicated rau kev siv thaum cev xeeb tub thiab lactation (noj niam mis) .Txoj kev tiv thaiv rau lub siab ua haujlwm tsis zoo.Qhov tshuaj no yog contraindicated rau siv nyob rau hauv lub siab ua haujlwm tsis zoo.Qhov uas ua rau lub raum tsis zoo ua haujlwm.Qhov tshuaj no yog contraindicated rau siv nyob rau hauv lub raum tsis zoo.

Siv rau cov neeg mob laus

Nws tsis pom zoo kom siv cov tshuaj rau cov neeg mob hnub nyoog laus dua 60 xyoo uas ua haujlwm lub cev hnyav, vim tias qhov pheej hmoo ntawm mob lactic acidosis.

Cov lus qhia tshwj xeeb rau kev txais neeg kawm Metfogamma 1000

Thaum kho, kev saib xyuas lub raum kev ua haujlwm yog qhov tsim nyog; kev txiav txim siab ntawm cov ntshav lactate yuav tsum tau ua yam tsawg 2 zaug hauv ib xyoos, nrog rau qhov pom ntawm myalgia. Nrog kev txhim kho ntawm cov kab mob lactic acidosis, kev txiav tawm ntawm kev kho mob yog yuav tsum tau ua. Teem tsis pom zoo rau kev mob hnyav, kev raug mob, thiab qhov pheej hmoo ntawm lub cev qhuav dej. Nrog kev kho ua ke nrog sulfonylurea derivatives, ua tib zoo saib xyuas ntshav qabzib concentration yog qhov tsim nyog. Kev siv tshuaj tiv thaiv kab mob nrog kev pom zoo nyob hauv tsev kho mob.

Noj ntau dhau

Cov tsos mob tuag taus lactic acidosis yuav tsim. Qhov ua rau kev txhim kho ntawm cov kab mob lactic acid tuaj yeem tseem yog kev ruaj khov ntawm cov tshuaj vim tias lub zog ua haujlwm tsis zoo. Cov tsos mob ua ntej tshaj plaws ntawm cov kab mob lactic acidosis yog xeev siab, ntuav, raws plab, txo qis lub cev kub, mob plab, mob leeg nqaij, yav tom ntej ua pa sai, kiv taub hau, tsis hnov ​​qab thiab txhim kho tsis nco qab.

Kev Kho Mob: yog tias muaj cov cim qhia txog lactic acidosis, kev kho mob nrog Metfogamma 1000 yuav tsum nres tam sim ntawd, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob sai thiab, tau txiav txim siab qhov concentration ntawm lactate, paub meej tias kev kuaj mob. Hemodialysis siv tau zoo tshaj plaws rau kev tshem tawm lactate thiab metformin tawm hauv lub cev. Yog tias tsim nyog, nqa tawm cov kev kho mob.

Nrog cov kev kho ua ke nrog sulfonylureas, cov ntshav qog ntshav qab zib yuav ua mob.

Kev sib cuam tshuam nrog Lwm Yam Tshuaj

Nrog rau kev siv nifedipine tib lub sij hawm nce nqus ntawm metformin, C_maxslows hauv excretion.

Cov tshuaj Cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) zais cia rau hauv cov tubules sib tw rau tubular thauj cov tshuab thiab, nrog kev kho lub sijhawm ntev, tuaj yeem nce C_max 60% metformin.

Nrog rau kev siv tib lub sijhawm nrog sulfonylurea derivatives, acarbose, insulin, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide thiab beta-blockers, nws yog qhov muaj peev xwm nce hypoglycemic effect ntawm metformin.

Nrog rau kev siv tib lub sijhawm nrog GCS, qhov ncauj tawm tsam, epinephrine (adrenaline), sympathomimetics, glucagon, cov thyroid hormones, thiazide thiab loopback diuretics, phenothiazine derivatives thiab nicotinic acid, qhov txo qis hauv cov nyhuv hypoglycemic ntawm metformin yog ua tau.

Cimetidine qeeb qeeb ntawm kev txiav tawm cov tshuaj metformin, vim tias qhov kev pheej hmoo ntawm lactic acidosis nce ntxiv.

Metformin tej zaum yuav ua rau cov tshuaj anticoagulants tsis muaj zog (coumarin derivatives).

Nrog rau kev tswj hwm ua ke nrog ethanol, txoj kev txhim kho ntawm cov kab mob lactic acidosis yog ua tau.

Cov Cai Siv Tshuaj So

Cov tshuaj yog ntawv yuav tshuaj.

Cov lus thiab cov xwm txheej ntawm kev cia Metfogamma 1000

Cov tshuaj yuav tsum muab khaws cia kom deb ntawm qhov ncav cuag ntawm cov menyuam ntawm qhov kub tsis tshaj li 25 ° C. Txee lub neej yog 4 xyoos.

Kev siv cov tshuaj Metfogamma 1000 tsuas yog raws li kws kho mob tau hais tseg, cov lus qhia tau muab rau siv!

Daim ntawv tso tawm Metfogamma 1000, ntim tshuaj thiab muaj pes tsawg leeg.

Coated ntsiav tshuaj
1 tab
metformin hydrochloride
1 g

Cov muaj mob: hypromellose (15,000 CPS), magnesium stearate, povidone (K25).

Lub plhaub muaj pes tsawg leeg: hypromellose (5CPS), macrogol 6000, titanium dioxide.

10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs - hlwv (12) - pob khoom los ntawm cardboard.
15 Pcs. - hlwv (2) - pob khoom los ntawm cardboard.
15 Pcs. - hlwv (8) - pob khoom los ntawm cardboard.

LUS PUB HUAM TXHEEJ TXHEEM MOO ZOO.
Txhua cov lus qhia tau muab nthuav tawm tsuas yog ua rau kom paub txog cov tshuaj, koj yuav tsum sab laj nrog tus kws kho mob txog kev siv.

Pharmacological kev ua yeeb yam Metfogamma 1000

Qhov ncauj hypoglycemic tus neeg sawv cev los ntawm pab pawg ntawm biguanides (dimethylbiguanide). Tus txheej txheem ntawm kev ua ntawm metformin yog txuam nrog nws lub peev xwm los txwv gluconeogenesis, nrog rau kev tsim cov roj dawb dawb thiab oxidation ntawm cov rog. Metformin tsis cuam tshuam rau cov tshuaj insulin hauv cov ntshav, tab sis hloov nws cov chaw muag tshuaj los ntawm kev txo qis ntawm qhov khi ntawm cov insulin kom dawb thiab nce qhov feem ntawm cov insulin rau proinsulin. Qhov kev sib txuas tseem ceeb hauv cov txheej txheem ntawm kev ua ntawm metformin yog qhov kev xav ntawm cov piam thaj los ntawm cov leeg nqaij.

Metformin txhim kho cov ntshav ncig hauv lub siab thiab ua kom nrawm hloov pauv ntawm cov piam thaj rau glycogen. Txo cov qib triglycerides, LDL, VLDL. Metformin kho txhim kho cov khoom fibrinolytic ntawm cov ntshav los ntawm kev tiv thaiv cov nqaij mos-plasminogen activator inhibitor.

Pharmacokinetics ntawm cov tshuaj.

Metformin yog nqus los ntawm cov hnyuv plab. Cmax hauv ntshav tau txog li 2 teev tom qab kev noj mov. Tom qab 6 teev, kev nqus ntawm lub plab zom mov xaus thiab qhov kev nqus ntawm metformin hauv cov ntshav maj mam poob qis.

Nws xyaum tsis khi rau cov plasma protein. Nws accumulates nyob rau hauv salivary qog, mob siab thiab ob lub raum.

T1 / 2 - 1.5-4.5 teev .Nws yog tawm los ntawm ob lub raum.

Yog tias ua kom lub raum khiav tsis zoo, ua kom ntau ntawm metformin yog ua tau.

Dosage thiab txoj hauv kev ntawm kev tswj hwm tshuaj.

Rau cov neeg mob tsis tau txais insulin, hauv thawj 3 hnub - 500 mg 3 zaug / hnub lossis 1 g 2 zaug / hnub thaum lossis tom qab noj mov. Txij hnub tim 4 mus txog rau hnub 14 - 1 g 3 zaug / hnub. Tom qab 15 hnub, qhov hno tshuaj tau raug hloov kho mus rau hauv tus account qib ntawm cov piam thaj hauv cov ntshav thiab zis. Kev saib xyuas qhov koob tshuaj yog 100-200 mg / hnub.

Nrog rau kev siv tshuaj insulin ib txhij ntawm ib koob tsawg dua 40 units / hnub, kev noj tshuaj ntawm cov tshuaj metformin yog qhov qub, thaum lub koob tshuaj insulin tuaj yeem maj mam txo qis (los ntawm 4-8 units / hnub txhua lwm hnub). Yog tias tus neeg mob tau txais ntau dua 40 units / hnub, tom qab ntawd kev siv cov metformin thiab txo qis ntawm cov tshuaj insulin yuav tsum muaj kev saib xyuas zoo thiab raug coj hauv tsev kho mob.

Sab Phim Npauj Metphogamma 1000:

Los ntawm lub plab zom mov: ua tau (feem ntau thaum pib kho) xeev siab, ntuav, raws plab.

Los ntawm cov kab mob endocrine: hypoglycemia (feem ntau yog siv thaum tsis txaus noj).

Los ntawm sab ntawm cov metabolism: hauv qee kis - lactic acidosis (yuav tsum muaj kev tso tseg kev kho mob).

Los ntawm cov kab mob hemopoietic: qee kis - megaloblastic anemia.

Contraindications rau cov tshuaj:

Kev ua txhaum ntawm daim siab thiab lub raum, lub plawv thiab lub ntsws tsis ua haujlwm, mob sai ntawm myocardial infarction, ntev cawv, mob ntshav qab zib tsis nco qab, ketoacidosis, mob lactic acidosis (suav nrog keeb kwm), mob ntshav qab zib ko taw, cev xeeb tub, lactation, hypersensitivity rau metformin.

TEJ YEEM THIAB LUS
Contraindicated nyob rau hauv cev xeeb tub thiab lactation.

Cov lus qhia tshwj xeeb rau kev siv Metfogamma 1000.

Nws tsis pom zoo rau mob hnyav, dhau mus ua kab mob sib kis thiab mob o, raug mob, mob phais mob sai, thiab muaj kev puas tsuaj ntawm lub cev qhuav dej.

Tsis txhob siv ua ntej kev phais thiab tsis pub dhau 2 hnub tom qab lawv tau ua.

Nws tsis pom zoo kom siv cov metformin hauv cov neeg mob hnub nyoog tshaj 60 xyoo thiab cov neeg ua haujlwm hnyav lub cev, uas cuam tshuam nrog kev pheej hmoo ntawm kev tsim mob lactic acidosis.

Thaum kho, nws yog ib qho tsim nyog los saib xyuas lub raum kev ua haujlwm, qhov kev txiav txim siab ntawm cov ntsiab lus lactate hauv ntshav yuav tsum tau nqa tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia.

Metformin tuaj yeem siv ua ke nrog sulfonylureas. Hauv qhov no, tshwj xeeb tshaj yog saib xyuas cov ntshav ntshav qab zib kom tsim nyog.

Kev siv cov metformin ua ib feem ntawm kev sib xyaw ua ke nrog kev siv tshuaj insulin yog raug pom zoo hauv tsev kho mob.

Kev sib cuam tshuam ntawm Metfogamma 1000 nrog rau lwm cov tshuaj.

Nrog tib lub sijhawm siv nrog sulfonylurea derivatives, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, nrog clofibrate, cyclophosphamide, cov nyhuv hypoglycemic ntawm metformin tej zaum yuav ua kom zoo dua.

Nrog rau kev siv ua ke nrog GCS, tshuaj tiv thaiv qog rau kev tswj hwm qhov ncauj, adrenaline, glucagon, cov thyroid hormones, phenothiazine derivatives, thiazide diuretics, nicotinic acid derivatives, txo qis hauv cov nyhuv hypoglycemic ntawm metformin yog ua tau.

Kev siv cov cimetidine ntau heev yuav ua rau muaj kev pheej hmoo ntawm tus mob lactic acidosis.

3D duab

Cov Tshuaj Hauv Tshuaj

Nws inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm txoj hnyuv, txhim kho kev siv ntawm cov kua nplaum ntev, thiab ua rau muaj kev cuam tshuam ntawm cov ntaub so ntswg mus rau insulin. Txo cov theem ntawm triglycerides thiab qis lipoproteins ntau hauv cov ntshav. Nws muaj cov nyhuv fibrinolytic (tiv thaiv kev ua haujlwm ntawm cov nqaij-plasminogen activator inhibitor), ua kom lub zog lossis txo qhov hnyav ntawm lub cev.

Sab sij huam

Los ntawm cov hlab plawv system thiab ntshav (hematopoiesis, hemostasis): Qee qhov megaloblastic anemia.

Los ntawm cov hnyuv: xeev siab, ntuav, mob plab, raws plab, tsis qab los noj mov, yog xim hlau hauv qhov ncauj.

Los ntawm sab ntawm cov metabolism: hypoglycemia, tsis tshua muaj mob, cov kab mob lactic acidosis (yuav tsum muaj kev tso tshuaj kho mob).

Kev tsis haum tshuaj: daim tawv nqaij ua pob.

Qhov nquag thiab qhov mob ntawm cov kev mob tshwm sim los ntawm qhov mob hnyuv tuaj yeem txo qis nrog maj mam nce ntxiv ntawm cov koob tshuaj metformin. Muaj qee zaus, mob tshwm sim kab mob siab hauv lub siab los yog mob rau daim siab ua kom ploj mus tom qab tshem tawm yeeb tshuaj.

Los ntawm sab ntawm cov metabolism: nrog rau kev kho mob ntev - hypovitaminosis B₁₂ (malabsorption.)

Tsuas tshuaj thiab tswj hwm

Sab hauv thaum noj mov, haus dej kom ntau (ib khob dej). Cov koob tshuaj tau teem ib lub zuj zus, ua rau qhov kev txiav txim siab ntawm cov piam thaj hauv cov ntshav.

Thawj koob tshuaj feem ntau yog 500–1000 mg (1 / 2–1 ntsiav tshuaj) ib hnub, ib qho kev nce qib ntxiv ntawm koob tshuaj yog tau nyob ntawm cov txiaj ntsig ntawm txoj kev kho.

Kev saib xyuas txhua hnub koob tshuaj yog 1-2 g (1-2 ntsiav tshuaj) ib hnub, qhov siab tshaj plaws - 3 g (3 ntsiav tshuaj) hauv ib hnub. Kev teem sij hawm ntawm cov koob tshuaj ntau dua tsis ua rau cov nyhuv ntawm kev kho mob.

Hauv cov neeg mob laus, cov tshuaj txhua hnub yuav tsum tsis pub tshaj 1000 mg / hnub.

Lub chav kawm ntawm kev kho mob ntev.

Vim tias qhov pheej hmoo ntawm cov kab mob lactic acidosis, cov koob tshuaj yuav tsum tau txo qis hauv cov teeb meem hauv lub cev loj hauv lub cev.

Cov lus qhia tshwj xeeb

Nws tsis pom zoo rau cov kab mob kis mob siab lossis kis hnyav ntawm tus kab mob sib kis thiab mob, kev raug mob, mob kab mob sai, ua ntej kev phais mob thiab hauv 2 hnub tom qab lawv tau ua tiav, nrog rau 2 hnub ua ntej thiab tom qab kuaj mob (radiological thiab radiological) kev siv ntawm cov ntawv xov xwm sib piv). Nws yuav tsum tsis txhob siv rau hauv cov neeg mob ntawm kev noj zaub mov nrog cov kev txwv ntawm lub caloric kom tsawg (tsawg dua 1000 kcal / hnub).Kev siv cov tshuaj tsis pom zoo rau cov neeg muaj hnub nyoog 60 xyoo uas ua haujlwm lub cev hnyav (vim tias qhov pheej hmoo ntawm kev tsim mob lactic acidosis).

Nws yog qhov ua tau los siv cov tshuaj nyob rau hauv ua ke nrog sulfonylurea derivatives lossis insulin. Hauv qhov no, tshwj xeeb tshaj yog saib xyuas cov ntshav ntshav qab zib kom tsim nyog.

Cuam Tshuam rau kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog tshuab. Tsis muaj cov nyhuv (thaum siv los ua kev kho mob monotherapy). Ua ke nrog lwm tus kab mob hypoglycemic (sulfonylurea derivatives, insulin, thiab lwm yam), kev txhim kho hypoglycemic lub xeev yog muaj peev xwm, nyob rau hauv uas muaj peev xwm tsav tsheb thiab koom nrog lwm yam kev muaj feem phom sij uas xav tau kev nce siab thiab ceev ntawm psychomotor cov kev tsis taus.

Chaw tsim tshuaj paus

Kev sau npe daim ntawv sau npe: Verwag Pharma GmbH & Co. KG, Kalverstrasse 7, 71034, Beblingen, Lub Tebchaws Yelemees.

Chaw tsim tshuaj paus: Dragenopharm Apotheker Püschl GmbH & Co. KG, Lub Tebchaws Yelemees.

Tus sawv cev chaw haujlwm / lub koomhaum lees txais cov lus thov: lub chaw sawv cev ntawm lub tuam txhab Vervag Pharma GmbH & Co. CG nyob rau hauv Lavxias Federation.

117587, Moscow, Warsaw txoj kev loj, 125 F, bldg. 6.

Tel.: (495) 382-85-56.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, lub sijhawm lossis tom qab noj mov tag, rau cov neeg mob tsis tau txais insulin - 1 g (2 ntsiav tshuaj) 2 zaug hauv ib hnub rau thawj 3 hnub lossis 500 mg 3 zaug hauv ib hnub, tom qab ntawd los ntawm 4 rau 14 hnub - 1 g 3 zaug hauv ib hnub, tom qab 15 hnub kev noj tshuaj tuaj yeem txo qis rau hauv tus account cov ntsiab lus ntawm cov piam thaj hauv cov ntshav thiab zis. Kev tu cov koob tshuaj txhua hnub - 1-2 g.

Cov ntsiav tshuaj rov qab (850 mg) tau noj 1 thaum sawv ntxov thiab yav tsaus ntuj. Qhov siab tshaj plaws niaj hnub noj yog 3 g.

Nrog rau kev siv tshuaj insulin ib txhij ntawm ib koob tsawg dua 40 units / hnub, kev noj tshuaj ntawm cov tshuaj metformin yog qhov qub, thaum lub koob tshuaj insulin tuaj yeem maj mam txo qis (los ntawm 4-8 units / hnub txhua lwm hnub). Thaum lub koob tshuaj insulin ntau dua 40 units / hnub, kev siv tshuaj metformin thiab txo qis ntawm cov tshuaj insulin yuav tsum muaj kev saib xyuas zoo thiab nqa tawm hauv tsev kho mob.

Cov lus nug, lus teb, tshuaj xyuas ntawm cov tshuaj Metfogamma 1000

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Kev cuam tshuam nrog lwm yam tshuaj

Nifedipine nce ntxiv kev nqus, C_tahslows hauv excretion. Cov tshuaj Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, thiab vancomycin) zais cia hauv cov tubules sib tw rau cov tshuab thauj tubular thiab, nrog kev kho lub sijhawm ntev, tuaj yeem nce C_tah los ntawm 60%.

Thaum siv ib txhij nrog sulfonylurea derivatives, acarbose, insulin, non-steroidal anti-inflammatory drugs, monoamine oxidase inhibitors, oxytetracycline inhibitors, angiotensin-hloov enzyme derivatives, • lofibrate derivatives, cyclophosphamide, cov tshuaj tiv thaiv ntshav qabzib, nws yog ib qho ua tau ntau ntxiv rau kev siv glucocort. , epinephrine, sympathomimetics, glucagon, cov thyroid hormones, thiazide thiab tsiaj evymi "diuretics, phenothiazine derivatives, nicotinic acid tej zaum yuav txo tus hypoglycemic kev txiav txim ntawm Metformin.

Cimetidine qeeb qeeb ntawm kev txiav tawm cov metformin, uas ua rau muaj kev pheej hmoo ntawm lactic acidosis. Metformin tej zaum yuav ua rau cov tshuaj anticoagulants tsis muaj zog (coumarin derivatives). Nrog rau kev haus cawv ib txhij, lactic acidosis yuav pib mob.

Daim ntawv thov nta

Thaum kho, nws yog qhov yuav tsum tau saib xyuas lub raum ua haujlwm. Tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia, ib qho kev txiav txim siab ntawm lub plasma lactate cov ntsiab lus yuav tsum tau nqa tawm. Nws yog qhov ua tau los siv Metfogamma® 1000 hauv kev sib xyaw nrog sulfonylurea derivatives lossis insulin. Hauv qhov no, tshwj xeeb tshaj yog saib xyuas cov ntshav ntshav qab zib kom tsim nyog.

Qhov cuam tshuam ntawm kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog kev ua haujlwm Thaum siv cov tshuaj nyob rau hauv monotherapy, nws tsis muaj kev cuam tshuam lub peev xwm ntawm kev tsav tsheb thiab ua haujlwm nrog mechanism. Thaum metformin koom ua ke nrog lwm cov kab mob hypoglycemic (sulfonylurea derivatives, insulin, thiab lwm yam), hypoglycemic tej yam kev mob yuav tshwm sim uas muaj peev xwm tsav tsheb thiab koom nrog lwm cov kev muaj feem phom sij uas xav tau kev nce siab thiab cov kev xav sai psychomotor cuam tshuam.