Yuav Ua Li Cas Digital > Kev khomob thiab kev tiv thaiv

"Tsifran" yog tsim rau cov kab mob nram qab no: kev kis kab mob ntawm cov genitourinary system (mob ntsws thiab mob pyelonephritis, cystitis, prostatitis, epididymitis), mob ntsws ua pa (mob ntsws, ntsws, mob ntsws, ua kom mob ntsws, mob ntsws, mob ntsws, mob ntsws, mob ntsws, mob ntsws), mob ntsws , mob rau sab hauv, mob rau ntawm ENT cov kabmob (nruab nrab thiab sab nraud otitis media, sinusitis, mastoiditis), kis mob ntawm daim tawv nqaij thiab cov nqaij mos (kub hnyiab, qhov txhab, mob rau voos, voos), mob voos (peritonitis, typhoid fever, cholangitis), kab mob hauv lub cev thiab mob kis me me plab mog (endometritis, salpingitis), kab mob ntawm cov pob qij txha thiab cov pob txha.

Cov koob tshuaj thiab lub sijhawm ntawm kev kho mob "Tsifran" yog teem los ntawm tus kws kho mob, nyob hauv txhua tus mob, raws qhov mob hnyav, cov kab mob kis tau, tus neeg mob lub hnub nyoog, lub cev nyhav thiab lub raum kev ua haujlwm. Rau cov menyuam yaus txij 12 xyoo "Tsifran" tau sau rau hauv ib hnub ib zaug ntawm 5-10 mg rau 1 kg ntawm lub cev qhov hnyav, uas tau muab faib ua 2 koob tshuaj. Cov ntsiav tshuaj yuav tsum tau noj ua ntej noj mov. Cov neeg laus "Tsifran" tau muab tso rau qhov quav (maj mam) hauv daim ntawv ntawm infusions hauv qhov ntau ntawm 200 mg 2 zaug hauv ib hnub rau kev kis tus kab mob ntawm cov mob txeeb zig thiab sab qis qis. Txhawm rau lwm yam mob, cov tshuaj tau muab rau hauv qhov ntau npaum li cas ntawm 200 mg nrog ncua sijhawm ntawm 12 teev .Txoj kev mob qog ua kom lub cev tsis zoo, cov tshuaj txhua hnub raug txo tsawg 2 zaug. Hauv qee kis, tom qab kev tswj hwm iv, lawv hloov mus rau kev tswj hwm qhov ncauj ntawm cov tshuaj. Kev kho mob rau kev kis mob nyhav tau pib tsawg kawg 5-7 hnub. Tom qab cov tsos mob ploj, txoj kev kawm tau txuas ntxiv rau 3 hnub ntxiv.

Cov kev mob tshwm sim thiab contraindications rau siv ntawm "Tsifran"

"Tsifran" tuaj yeem ua rau muaj kev mob tshwm sim xws li pom meej, ntuav, xeev siab, mob plab, mob siab, mob taub hau, mob caj dab, kiv taub hau, chim siab, tsis meej pem, tsaus muag, mob taub hau, tshee tshee ntawm qhov kawg, pom kev plooj plooj, hnov tsw, hnov qab, lub plawv ntxhov , eosinophilia, leukopenia, leukocytosis, anemia, thrombocytosis, hemolytic anemia, ntau ntxiv kev ua haujlwm ntawm daim siab enzymes, hyperglycemia, hematuria, glomerulonephritis, dysuria, polyuria, tso zis cia, tso ntshav tawm mus, myalgia, arthralgia, tendovag yarns, mob caj dab, txog leeg rupture, pseudomembranous mob plab, Candidiasis, generalized tsis muaj zog.

Cov tshuaj yog contraindicated nyob rau hauv cov ntaub ntawv ntawm hypersensitivity rau nws cov Cheebtsam, thaum cev xeeb tub thiab lactation, rau cov menyuam muaj hnub nyoog qis dua 12 xyoos. Nrog rau kev saib xyuas tshwj xeeb, "Tsifran" yog siv rau hauv cov neeg uas muaj kev mob tshwm sim heev ntawm cov hlab ntsha txhaws, nrog rau cov kab mob cerebrovascular, mob hlwb, mob vwm, mob vwm, mob plab thiab / lossis mob raum, thaum laus.

Chaw tsim tshuaj paus

1 cov ntsiav tshuaj coated muaj:
cov tshuaj nquag: ciprofloxacin hydrochloride USP, sib npaug rau ciprofloxacin 500 mg, tinidazole BP 600 mg,
kev nthuav dav: microcrystalline cellulose, colloidal anhydrous silicon, magnesium stearate, sodium starch glycolate, sodium lauryl sulfate. Cov khoom xyaw ntawm txheej sab nraud ntawm granules: sodium starch glycolate, purified talc, sodium lauryl sulfate, microcrystalline cellulose, colloidal anhydrous silicon, magnesium stearate. Lub plhaub: Opadry daj, ua cov dej lim.

Pharmacological kev txiav txim

Cov Tshuaj Hauv Tshuaj
Tsifran ST yog kev npaj ua ke rau kev kho mob sib xyaw ua ke los ntawm cov kab mob sib deev thiab aerobic, nrog rau kev kis mob rau txoj hnyuv, piv txwv, raws plab, mob plab zawv plab, amoebic los yog sib xyaw (amoebic thiab kab mob) xwm. Tinidazole ua tau zoo rau cov kab mob anaerobic xws li Clostridium difficile, Clostridium perfringens, Bacteroides fragilis, Peptococcus thiab Peptostreptococcus anaerobius. Cov kab mob Anaerobic ua rau cov kab mob hauv plab feem ntau ua rau mob plab, mob lub plab, lub ntsws, lossis lub qhov ncauj. Thaum tus mob anaerobic, feem ntau, muaj kev sib xyaw ntawm cov kab mob anaerobic thiab aerobic. Yog li ntawd, nrog kev sib xyaw ua ke anaerobic, ib qho tshuaj tua kab mob tawm tsam cov kab mob aerobic ntxiv rau txoj kev kho.

Ciprofloxacin yog cov tshuaj tua kab mob ntau yam los tiv thaiv feem ntau aerobic gram-positive thiab gram-negative microorganisms xws li E. coli, Klebsiella spp., S.typhi thiab lwm yam kab mob ntawm Salmonella, P.mirabilis, P.vulgaris, Yersinia enterocoilitica, Ps.aeruginosa, Shigella flexneri, Shigella sonnei, H.ducreyi, H.influenzae, N..gonorrhoeae, M. catarrhalis, V. cholerae, B. fragilis, Staph.aureus (suav nrog hom kab mob methicillin tiv thaiv), Staph.epidermidis, Strep.pyogenes, Strep. mob ntsws, Chlamidia, Mycoplasma, Legionella, thiab Mycobacterium tuberculosis.

Cov Tshuaj Pharmacokinetics
Ob leeg ciprofloxacin thiab tinidazole tau ua haujlwm zoo nyob rau hauv txoj hnyuv plab. Ncov cov ntsiab lus ntawm txhua qhov kev ua tiav tau tiav hauv 1 txog 2 teev. Kev ua tiav bioavailability ntawm tinidazole yog 100%, thiab cov ntshav protein khi yog 12%. Qhov kev tshem tawm ib nrab-lub neej yog li 12-14 teev. Cov tshuaj sai sai rau cov ntaub so ntswg ntawm lub cev, kom txog siab nyob rau ntawd. Tinidazole nkag mus rau hauv cov kua dej ua kom hlab ntshav ntawm qhov ua kom sib npaug nrog nws cov concentration hauv cov ntshav thiab yauv ua kom rov qab nqus tau rau hauv cov hlab plab hlaus. Tinidazole ua tawm hauv cov kua tsib hauv cov ntsiab lus me ntsis qis dua 50% ntawm nws qhov siab hauv ntshav. Kwv yees li 25% ntawm cov koob tshuaj tau pom tias tsis hloov pauv hauv cov zis.

Metabolites ua tau nce li 12% ntawm cov koob tshuaj uas tau siv thiab nws kuj tseem tawm hauv cov zis. Nrog rau qhov no, muaj qee qhov tawm ntawm tinidazole nrog quav.
Ciprofloxacin zoo nqus tom qab kev tswj hwm qhov ncauj. Lub bioavailability ntawm ciprofloxacin yog li 70%. Thaum ua ke nrog cov khoom noj, qhov nqus ntawm ciprofloxacin qeeb qeeb. 20-40% ntawm cov tshuaj khi rau cov ntshav plasma. Ciprofloxacin nkag mus rau hauv lub cev thiab cov nqaij mos: lub ntsws, tawv nqaij, rog, mob pob txha thiab pob txha mos, nrog rau cov pob txha thiab lub plab, nrog rau cov prostate. Cov tshuaj muaj nyob hauv ntau cov kua qaub ncaug, cov hnoos qeev hauv lub qhov ntswg kab noj hniav thiab bronchi, phev, lymph, peritoneal kua, bile thiab prostate secretion. Ciprofloxacin yog kho qee qhov mob siab los ntawm daim siab. Kwv yees li 50% ntawm qhov kev noj tshuaj tau tawm yog tsis hloov pauv hauv cov zis, ntxiv rau 15% hauv cov tshuaj ua kom muaj zog, xws li oxociprofloxacin. Qhov seem ntawm cov koob tshuaj tau tawm hauv cov kua tsib, qee qhov nkag siab dua. Kwv yees li 15-30% ntawm ciprofloxacin yog tawm hauv cov quav. Qhov kev tshem tawm ib nrab-lub neej yog li ntawm 3.5-4.5 teev. Kev tshem tawm ib nrab-lub neej tuaj yeem rub tau ntev nrog kev mob raum tsis zoo thiab hauv cov neeg laus.

Tsifran ST yog qhia rau kev kho mob ntawm kev kis mob hauv qab no:
Kev kho mob los ntawm kev sib xyaw ua ke los ntawm cov kab mob rhiab ua rau tsis taus thiab mob aerobic: mob ua paug, mob ntsws, ua paug, mob plab, mob rau lub plab, mob txhaws ntshav, mob rau tom qab mob nrog rau kev muaj kab mob aerobic thiab anaerobic, mob ua paug osteomyelitis, mob rau cov tawv nqaij thiab cov nqaij mos, ua rau mob ntshav qab zib ko taw ”, qhov ncauj tawm, mob voos ntawm qhov ncauj (nrog rau mob peridontitis thiab periostitis).
Kho mob raws plab los yog mob plab ntawm amoebic los yog sib xyaw (amoebic thiab kab mob) etiology.

Cev xeeb tub thiab lactation

Kev siv Cyfran CT thaum cev xeeb tub tsis pom zoo. Tinidazole tuaj yeem muaj cov nyhuv carcinogenic thiab mutagenic. Ciprofloxacin hla kev nrhav ntshav hematoplacental. Kev siv tsifran ST yog sib kis thaum pub niam mis. Tinidazole thiab ciprofloxacin yog tawm hauv niam cov kua mis. Yog li no, thaum lactation, yog tias nws yuav tsum tau siv Tsifran ST, kev pub mis niam yuav tsum tau tsum.

Cov Yuav Tsum Tau Ua

Cifran ST yog sib kis rau cov neeg mob uas lub siab tsis haum (ua xua) rau ib qho kev sib txuas ntawm fluoroquinolone lossis imidazole.
Tsifran ST kuj tseem pom zoo rau cov neeg mob uas muaj keeb kwm ntawm cov mob ntshav. Nrog inhibition ntawm cov pob txha mob hematopoiesis, mob porphyria.
Tsifran ST yog sib raug rau cov neeg mob uas muaj cov hlab ntsha neurological.
Tsifran ST yog contraindicated rau hauv cov neeg mob uas menyuam yaus (txog 18 xyoo).

Nrog saib xyuas
Cov tshuaj yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas mob atherosclerosis ntawm cov hlab ntsha hauv lub hlwb, nrog cerebrovascular cov xwm txheej, nrog kev mob hlwb, mob vwm, nrog mob vwm, mob raum thiab / lossis lub siab tsis ua haujlwm.
Thaum siv cov tshuaj hauv cov laus, tsis muaj teeb meem tseem ceeb tau sau tseg. Txawm li cas los xij, hauv cov neeg mob laus, kev txo lub hnub nyoog ntawm lub raum ua tau, yog li ceev faj yuav tsum siv thaum siv cov tshuaj hauv cov neeg mob ntawd.

Sab sij huam

Los ntawm lub plab zom mov: tsis qab los noj mov, lub qhov ncauj qhuav mucosa, "nws yog xim hlau" saj hauv lub qhov ncauj, xeev siab, ntuav, raws plab, mob plab, mob plab, cholestatic jaundice (tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob siab dhau los), kab mob siab, mob hepatonecrosis.
Los ntawm cov hlab ntsha hauv lub cev: mob taub hau, kiv taub hau, nce rog dhau los, muaj kev cuam tshuam ntawm kev txav mus los (suav nrog hauv lub cev ntawm lub cev), mob plab, tsis nco qab, tsis tshua muaj ntswj, tsis muaj zog, tshee tshee, pw tsis tsaug zog, tawm hws, nce siab intracranial, tsis meej pem, kev nyuaj siab, pom kev, nrog rau lwm yam kev qhia ntawm cov kev puas siab puas ntsws, mob taub hau, tsaus muag, mob hlab hlwb.
Ntawm ib feem ntawm cov khoom nruab nrog cev tsis hnov tsw, hnov qab saj thiab hnov tsw, tsis hnov qab lub ntsej muag (diplopia, hloov xim hloov xim), tinnitus, tsis hnov lus.
Los ntawm cov hlab plawv: tachycardia, mob plawv dhia tsis xwm yeem, txo cov ntshav siab.
Los ntawm cov kab mob ntshav hematopoietic: leukopenia, granulocytopenia, ua haujlwm ntshav, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
Ntawm ib feem ntawm cov kev ntsuas ntsuas: hypoprothrombinemia, muaj kev ua si ntau ntawm "daim siab hloov tsheb" thiab alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia
Los ntawm cov kab mob tawm hauv txoj hlab zis: hematuria, crystalluria (alkaline zis thiab tso zis tsawg), glomerulonephritis, dysuria, polyuria, tso zis cia, tsawg nitrogen excretory muaj nuj nqi ntawm lub raum, interstitial nephritis.
Ua xua: ua pob khaus, ua xua, tsim cov hlwv nrog los ntshav, thiab cov tsos ntawm cov nodules me ua cov kiav txhab, tshuaj kub taub hau, pom cov ntshav tawm ntawm daim tawv nqaij (petechiae), o ntawm lub ntsej muag lossis lub ntsej muag, ua tsis taus pa, eosinophilia, nce duab ntawm qhov muag, vasculitis, nodular erythema multiforme exudative (suav nrog Stevens-Johnson syndrome), mob ua paug epidermal necrolysis (Lyell's syndrome).
Lwm yam: arthralgia, mob caj dab, tendovaginitis, pob txha caj dab, asthenia, myalgia, superinfection (candidiasis, pseudomembranous colitis), yaug ntsej muag.

Kev sib txuam

Tinidazole
Ua kom muaj txiaj ntsig ntawm qhov tsis ncaj ntawm anticoagulants (txhawm rau kom muaj kev pheej hmoo los ntshav, qhov koob tshuaj yog txo los ntawm 50%) thiab kev ua haujlwm ntawm ethanol (disulfiram-xws li kev cuam tshuam).
Siv tau nrog sulfonamides thiab tshuaj tua kab mob (aminoglycosides, erythromycin, rifampicin, cephalosporins).
Nws tsis pom zoo kom muab tshuaj nrog ethionamide.
Phenobarbital accelerates metabolism hauv.
Ciprofloxacin
Vim tias txo qis hauv cov haujlwm ntawm microsomal oxidation kev ua haujlwm hauv hepatocytes, nws nce lub siab thiab lengthens lub neej ib nrab ntawm theophylline (thiab lwm yam xanthines, piv txwv li caffeine) ntawm qhov ncauj hypoglycemic tshuaj (PM), anticoagulants tsis ncaj, thiab pab txo cov prothrombin index.
Thaum muab sib xyaw nrog lwm cov tshuaj tua kab mob (beta-lactam tshuaj tua kab mob, aminoglycosides, clindamycin, metronidazole), synergism feem ntau pom.
Ua kom cov txiaj ntsig nephrotoxic ntawm cyclosporrin, qhov kev nce ntxiv ntawm cov ntshav creatinine tau sau tseg, hauv cov neeg mob zoo li no, qhov ntsuas no yuav tsum tau soj ntsuam 2 zaug hauv ib lub lis piam

Nyob rau tib lub sijhawm, nws ua kom muaj txiaj ntsig zoo ntawm cov nqi tiv thaiv tsis tau.
Kev tswj hwm ntawm qhov ncauj ua ke nrog Fe muaj cov tshuaj, cov tshuaj ua kom sib luag thiab cov tshuaj antacid uas muaj Mg2 +, Ca2 +, A13 + ua rau txo qis ntawm kev nqus ntawm ciprofloxacin, yog li nws yuav tsum tau siv tshuaj 1-2 teev ua ntej lossis 4 teev tom qab siv cov tshuaj saum toj no.
Cov tshuaj nonsteroidal anti-inflammatory (tsis suav nrog acetylsalicylic acid) muaj kev pheej hmoo ntawm qaug dab peg.
Didanosine txo qis kev nqus ntawm ciprofloxacin vim yog kev tsim muaj ntau txoj nrog nws, muaj Mg2 +, A13 + muaj nyob hauv didanosine.
Metoclopramide nrawm nrawm nrawm, uas ua rau lub sijhawm txo qis kom mus txog nws qhov siab tshaj plaws.
Qhov kev sib koom tes ntawm kev siv tshuaj uricosuric ua rau kev txo qis ntawm kev tshem tawm (nce txog 50%) thiab nce ntxiv ntawm cov ntshav plasma concentration ntawm ciprofloxacin.

Noj ntau dhau

Tsis muaj ib qho tshuaj tua kab mob tshwj xeeb, yog li ntawd, kev kho nrog kev siv ntau tshaj ntawm Cyfran CT yuav tsum muaj tsos mob thiab suav nrog cov kev ntsuas hauv qab no:
- Pom qhov ntuav lossis ntuav plab.
- Yuav kom ntsuas kev ntsuas rau lub cev kom tsim nyog.
- Pab tu.

Cov lus qhia tshwj xeeb

Nws raug nquahu kom tsis txhob raug tshav ntuj ntau dhau thaum lub sijhawm kho nrog Cifran ST, vim tias qee tus neeg mob fluoroquinolones muaj kev cuam tshuam phototoxicity. Yog tias phototoxicity tshua tshwm sim, tsum tsis txhob siv cov tshuaj tam sim ntawd.
Thaum siv tinidazole, nws muaj peev xwm (tab sis tsis tshua muaj) los txhim kho cov kab mob urticaria dav dav, o ntawm lub ntsej muag thiab lub suab nrov, txo qis ntshav siab, bronchospasm thiab dyspnea. Yog hais tias tus neeg mob ua xua rau ib qho imidazole derivative, ces tus ntoo khaub lig-rhiab rau tinidazole tej zaum yuav muaj kev txhim kho, kev txhim kho ntawm cov tshuaj tiv thaiv khaub thuas rau ciprofloxacin kuj tseem muaj peev xwm ua rau cov neeg mob ua xua rau lwm cov fluoroquinolone derivatives. Yog li, yog tias tus neeg mob tau muaj kev fab tshuaj rau cov tshuaj uas zoo sib xws, muaj peev xwm hla kev tsis haum nrog Cyfran ST yuav tsum raug txiav txim siab.
Nrog kev siv ua ke ntawm tinidazole nrog haus cawv, mob plab hauv plab, xeev siab thiab ntuav tuaj yeem tshwm sim. Yog li ntawd, kev sib xyaw ua ke ntawm Cifran ST thiab cawv yog contraindicated.

Txhawm rau kom tsis txhob muaj kev txhim kho crystallurgy, qhov kev pom zoo txhua hnub yuav tsum tsis pub dhau, kev haus dej txaus thiab kev saib xyuas cov kua qaub ua kua tseem ceeb heev. Ua rau tsaus muag teev zis.
Thaum kho lub sijhawm, koj yuav tsum tsis txhob koom nrog cov kev ua phom sij uas yuav tsum muaj kev saib xyuas ntau dua thiab ceev ntawm lub hlwb thiab lub cev kev hloov.
Cov neeg mob qaug dab peg, keeb kwm ntawm qaug dab peg, kab mob vascular thiab cov kiav txhab hauv lub hlwb, vim qhov kev hem thawj ntawm cov kev phiv tshuaj los ntawm cov kab mob hauv lub hauv nruab nrab, cov tshuaj yuav tsum raug txiav txim tsuas yog rau "tseem ceeb".
Yog tias mob raws plab thiab mob ntev dhau los thaum lub sijhawm lossis tom qab kev kho mob, kev kuaj mob pseudomembranous mob plab yuav tsum raug cais tawm, uas yuav tsum tshem tawm sai ntawm cov tshuaj thiab kev teem caij kho kom tsim nyog.
Nrog rau qhov tsos ntawm kev mob siab rau txoj leeg lossis nrog qhov pib ntawm thawj cov tsos mob ntawm kev mob raum, qhov kev kho yuav tsum tau tsum tsis ua ntxiv.
Thaum kho, cov duab ntawm cov ntshav peripheral yuav tsum tau saib xyuas.
Kev nyab xeeb thiab kev ua tau zoo rau kev kho mob thiab kev tiv thaiv tus mob anaerobic rau cov menyuam yaus uas tsis tau muaj 12 xyoos tsis tau tsim.

Dosage daim ntawv

Cov ntsiav tshuaj-yeeb yaj kiab, 500 mg

Ib ntsiav tshuaj muaj

cov tshuaj heev - ciprofloxacin hydrochloride 582.37 mg (sib npaug rau ciprofloxacin) 500.00 mg

tus zam: microcrystalline cellulose (Avicel PH101), pob kws hmoov txhuv, pob kws nplej (rau gluing), magnesium stearate, talc, anhydrous colloidal silicon dioxide, sodium starch glycolate (hom A), dej lim

Plhaub: cov dej lim dej, opadry OY-S-58910 dawb (hypromellose E464, titanium dioxide E171, polyethylene glycol 400, talc E553

Cov ntsiav tshuaj zoo li pob ua yeeb yaj kiab coated nrog zaj duab xis txheej los ntawm dawb mus rau yuav luag dawb, sau nrog "500" ntawm ib sab thiab du rau sab nraud.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, ciprofloxacin nrawm nrawm los ntawm qhov kawg ntawm txoj hnyuv me, kom mus txog qhov siab tshaj plaws cov tshuaj lom (Cmax) tom qab 60-90 feeb. Kev noj mov tsis cuam tshuam rau qib ntawm kev nqus ntawm cov tshuaj. Tom qab noj ib koob ntawm 250 mg thiab 500 mg, Cmax yog 0.8-2.0 mg / L thiab 1.5-2.9 mg / L, raws. Kev tsis raug cai ntawm bioavailability yog 70-80%. Cmax muaj qhov tso cai siv raws cov koob tshuaj.

Qhov ntim ntawm kev faib tawm ciprofloxacin yog 2-3 l / kg, uas ua kom ntseeg tau tias muaj kev faib khoom thoob plaws lub cev thiab cov ntaub so ntswg. Txij li cov qib ntawm kev khi rau cov ntshav plasma tsuas yog 20-30% thiab feem ntau ntawm cov tshuaj tau qhia hauv ntshav hauv daim ntawv tsis-ionized, yuav luag tag nrho cov koob tshuaj nyob rau hauv ib daim ntawv tsis qhia tawm tau muab faib rau qhov chaw tshwj xeeb-vascular.

Nws yog metabolized hauv daim siab. Qhov kev tshem tawm ib nrab-lub neej ua rau 3-5 teev. Nws yog tsuas yog raug tshem tawm tsis hloov hauv cov zis, ib feem hauv cov qauv metabolites. Li 10% tau tawm los ntawm txoj hnyuv, kwv yees li 1% ntawm ciprofloxacin yog ua rau hauv cov kab mob.

Pharmacokinetics hauv cov pab pawg neeg mob tshwj xeeb. Cov txiaj ntsig ntawm pharmacokinetic kev tshawb fawb ntawm ciprofloxacin hauv cov neeg mob laus qhia tsuas yog me ntsis txuas ntxiv ntawm ib nrab ntawm lub neej. Cov sib txawv no hauv pharmacokinetics tsis yog qhov tseem ceeb hauv tsev kho mob..

Tsis hlauv. Hauv cov neeg mob uas tsis muaj lub raum ua haujlwm, lub sijhawm ib nrab ntawm ciprofloxacin ntev dua me ntsis. Qee qhov xwm txheej, yuav tau kho ntau npaum li cas..

Daim siab ua haujlwm. Hauv cov kev tshawb fawb ua ntej cuam tshuam nrog cov neeg mob uas muaj lub siab ua haujlwm hauv lub siab, tsis muaj qhov txawv txav ntawm cov chaw muag tshuaj ntawm ciprofloxacin tau kuaj pom. Txawm li cas los xij, pharmacokinetics ntawm ciprofloxacin hauv cov neeg mob uas muaj lub siab tsis ua hauj lwm zoo yog tsis to taub tag nrho.

Tshuaj sib cuam tshuam. Thaum noj ciprofloxacin ntsiav tshuaj ib txhij nrog zaub mov, qhov nqus ntawm cov tshuaj yuav qeeb, vim tias qhov ntau tshaj plaws ntawm ciprofloxacin hauv cov ntshav tau mus txog tom qab yuav luag 2 teev, thiab tsis yog tom qab 1 teev. Nyob rau tib lub sijhawm, qhov nqus ntawm ciprofloxacin tag nrho tsis ntxhov. Thaum ua ke nrog cov tshuaj tiv thaiv kab mob uas muaj cov tshuaj magnesium lossis aluminium hydroxide, cov kev siv bioavailability ntawm ciprofloxacin tuaj yeem txo los ntawm 90% .

Ciprofloxacin yog sib kis rau cov neeg mob uas tau txais tizanidine.

Ciprofloxacin txo qis theophylline kev tshem tawm, uas tuaj yeem ua rau muaj kev nce ntxiv hauv cov ntshav theophylline concentration thiab muaj kev pheej hmoo ntau ntxiv ntawm cov hlab ntsha tsis zoo thiab lwm cov kev tsis zoo. Ciprofloxacin kuj tseem txo cov kev ua kom huv ntawm caffeine thiab inhibits qhov tsim ntawm nws cov metabolite paraxanthin.

Cov Tshuaj Hauv Tshuaj

Mechanism ntawm kev ua. Cov kab mob ua haujlwm ntawm ciprofloxacin yog vim kev thaiv cov enzymes topoisomerase II (DNA gyrase) thiab cov tshuaj topoisomerase IV, uas tsim nyog rau kev rov ua dua, hloov pauv, kho, thiab rov ua kom zoo ntawm cov kab mob DNA.

Lub tshuab kev txhim kho ntawm kev ua haujlwm. Cov tshuaj fluoroquinolone muaj feem cuam tshuam nrog kev hloov pauv hauv DNA gyrase genes, qhov ua tsis taus ntawm cov sab nraud cell membrane ntawm cov kab mob, los yog ua kom cov ejection proteins, uas ua rau muaj kev tshem tawm ntawm fluoroquinolones los ntawm lub cell. Hauv cov xwm txheej hauv vitro ciprofloxacin tsis kam pib maj mam dhau los ntawm kev sib txuam sib txawv. Qhov tshwm sim ntawm ciprofloxacin tsis kam ua ntau yam tshwm sim los ntawm qhov tshwm sim tshwm sim feem ntau nws txawv