Augmentin nyob rau hauv daim ntawv ntawm ncua kev kawm: cov lus qhia rau kev siv rau menyuam yaus
Hmoov rau qhov kev npaj tawm ntawm kev ncua rau qhov ncauj kev tswj hwm ntawm cov xim dawb lossis yuav luag dawb, nrog tus yam ntxwv tsis hnov tsw, thaum diluted, ncua kev ncua lossis dawb yuav luag tsim, thaum sawv, dej nag lossis daus dawb yuav luag tsim maj mam.
| 5 ml ntawm kev tshem tawm tiav. | |
| amoxicillin (nyob rau hauv daim ntawv ntawm amoxicillin trihydrate) | 125 mg |
| clavulanic acid (nyob rau hauv daim ntawv ntawm poov tshuaj clavulanate) * | 31,25 mg |
Tshwjxeeb: xanthan ntawm cov pos hniav - 12.5 mg, aspartame - 12,5 mg, succinic acid - 0.84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 150 mg, txiv kab ntxwv tsw 1 - 15 mg, txiv kab ntxwv tsw 2 - 11.25 mg, raspberry tsw - 22,5 mg, tsw muaj tsw "Cov npaws ntshav" - 23.75 mg, silicon dioxide - 125 mg.
11,5 g - iav fwj (1) ua tiav nrog lub hau ntsuas - pob khoom ntawm duab los qhia.
Hmoov rau qhov kev npaj tawm ntawm kev ncua rau qhov ncauj kev tswj hwm ntawm cov xim dawb lossis yuav luag dawb, nrog tus yam ntxwv tsis hnov tsw, thaum diluted, ncua kev ncua lossis dawb yuav luag tsim, thaum sawv, dej nag lossis daus dawb yuav luag tsim maj mam.
| 5 ml ntawm kev tshem tawm tiav. | |
| amoxicillin (nyob rau hauv daim ntawv ntawm amoxicillin trihydrate) | 200 mg |
| clavulanic acid (nyob rau hauv daim ntawv ntawm poov tshuaj clavulanate) * | 28,5 mg |
Tshwjxeeb: xanthan ntawm cov pos hniav - 12.5 mg, aspartame - 12,5 mg, succinic acid - 0.84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 79,65 mg, txiv kab ntxwv tsw 1 - 15 mg, txiv kab ntxwv tsw 2 - 11.25 mg, raspberry tsw - 22,5 mg, Hmoov qab zib "Cov suab thaj" - 23.75 mg, silicon dioxide - txog 552 mg.
7.7 g - iav fwj (1) ua tiav nrog lub hau ntsuas - pob khoom ntawm duab los qhia.
Hmoov rau qhov kev npaj tawm ntawm kev ncua rau qhov ncauj kev tswj hwm ntawm cov xim dawb lossis yuav luag dawb, nrog tus yam ntxwv tsis hnov tsw, thaum diluted, ncua kev ncua lossis dawb yuav luag tsim, thaum sawv, dej nag lossis daus dawb yuav luag tsim maj mam.
| 5 ml ntawm kev tshem tawm tiav. | |
| amoxicillin (nyob rau hauv daim ntawv ntawm amoxicillin trihydrate) | 400 mg |
| clavulanic acid (nyob rau hauv daim ntawv ntawm poov tshuaj clavulanate) * | 57 mg |
Tshwjxeeb: xanthan ntawm cov pos hniav - 12.5 mg, aspartame - 12,5 mg, succinic acid - 0.84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 79,65 mg, txiv kab ntxwv tsw 1 - 15 mg, txiv kab ntxwv tsw 2 - 11.25 mg, raspberry tsw - 22,5 mg, tsw zoo "Ncaj suab thaj" - 23.75 mg, silicon dioxide - txog li 900 mg.
12.6 g - iav fwj (1) ua tiav nrog lub hau ntsuas - pob khoom ntawm duab los qhia.
* nyob rau hauv kev tsim cov tshuaj, poov tshuaj clavulanate yog pw nrog 5% ntau dhau.
Pharmacological kev txiav txim
Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm β-lactamases, thiab yog li ntawd cov kev ua si spectrum ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.
Clavulanic acid, a β-lactamase inhibitor yam ntxwv ntawm kev siv rau penicillins, muaj peev xwm tsis muaj peev xwm tiv thaiv ntau yam ntawm β-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin resistant microorganisms. Clavulanic acid muaj qhov ua tau zoo txaus los tiv thaiv plasmid l-lactamases, uas feem ntau txiav txim siab qhov tawm tsam ntawm cov kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv chromosomal β-lactamases ntawm hom 1, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.
Muaj cov clavulanic acid nyob rau hauv Augmentin ® kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - act-lactamases, uas tso cai nthuav tawm cov tshuaj tua kab mob ntawm amoxicillin.
Cov hauv qab no yog hauv kev ua haujlwm hauv vitro ntawm amoxicillin nrog clavulanic acid.
Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid
Gram-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pyogenes 1,2, Streptococcus agalactiae 1,2, Streptococcus spp. (lwm beta hemolytic streptococci) 1,2, Staphylococcus aureus (nkag siab rau methicillin) 1, Staphylococcus saprophyticus (nkag siab rau methicillin), Staphylococcus spp. (coagulase-negative, rhiab rau methicillin).
Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.
Gram-positive anaerobes: Clostridium spp., Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus spp.
Gram-negative anaerobes: Bacteroides fragilis, Bacteroides spp., Capnocytophaga spp., Eikenella corrodens, Fusobacterium nucleatum, Fusobacterium spp., Porphyromonas spp., Prevotella spp.
Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
Cov kab mob rau cov uas yuav tiv taus cov tshuaj amoxicillin nrog clavulanic acid yog qhov yuav tshwm sim
Gram-negative aerobes: Escherichia coli 1, Klebsiella oxytoca, Klebsiella pneumoniae 1, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.
Gram-positive aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2, Streptococcus pawg Viridans 2.
Cov kab mob uas ib txwm muaj peev xwm tiv thaiv kev sib txuas ntawm amoxicillin nrog clavulanic acid
Gram-negative aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia.
Lwm yam: Chlamydia mob ntsws, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.
1 Rau cov kab mob microorganisms no, qhov ua tau zoo ntawm kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid tau pom nyob hauv kev tshawb fawb.
2 Hom kab ntawm cov kab no tsis tsim β-lactamases. Kev nkag siab nrog amoxicillin monotherapy qhia zoo ib yam li kev nkag siab zoo rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.
Cov Tshuaj Pharmacokinetics
Ob lub cev ua ke ntawm cov tshuaj Augmentin ®, amoxicillin thiab clavulanic acid, tau nrawm thiab nrawm los ntawm lub plab zom mov tom qab kev tswj hwm qhov ncauj. Qhov nqus ntawm cov tshuaj nquag yog qhov zoo dua hauv kev noj tshuaj thaum pib noj mov.
Augmentin ® 125 mg / 31.25 mg rau 5 ml qhov ncauj raug tshem tawm hmoov
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob tau 40 mg / 10 mg / kg lub cev hnyav / hnub ntawm Augmentin ®, hmoov rau kev ncua rau kev tswj hwm hauv 3 koob los ntawm qhov ncauj, 125 mg / 31.25 mg hauv 5 ml (156.25 mg).
Yooj yim pharmacokinetic
| Kev Npaj | Koob tshuaj (mg / kg) | C max (mg / l) | T max (h) | Auc (mg × h / l) | T 1/2 (h) |
| Amoxicillin | |||||
| Augmentin ® 125 mg / 31.25 mg rau ib 5 ml | 40 | 7.3±1.7 | 2.1 (1.2-3) | 18.6±2.6 | 1±0.33 |
| Clavulanic acid | |||||
| Augmentin ® 125 mg / 31.25 mg rau ib 5 ml | 10 | 2.7±1.6 | 1.6 (1-2) | 5.5±3.1 | 1.6 (1-2) |
Augmentin ® 200 mg / 28.5 mg hauv 5 ml qhov ncauj raug tshem tawm hmoov
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob tau Augmentin ®, hmoov rau lub qhov ncauj ncua, 200 mg / 28.5 mg hauv 5 ml (228.5 mg) ntawm koob tshuaj ntawm 45 mg / 6.4 mg / kg / hnub, muab faib ua 2 koob.
Yooj yim pharmacokinetic
| Yam khoom muaj sia | C max (mg / l) | T max (h) | AUC (mg × h / l) | T 1/2 (h) |
| Amoxicillin | 11.99±3.28 | 1 (1-2) | 35.2±5 | 1.22±0.28 |
| Clavulanic acid | 5.49±2.71 | 1 (1-2) | 13.26±5.88 | 0.99±0.14 |
Augmentin ® 400 mg / 57 mg qhov ncauj hmoov hauv 5 ml
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau txais hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg tuaj yeem noj qab haus huv tau noj ib zaug ntawm Augmentin ®, hmoov rau kev tshem tawm qhov ncauj, 400 mg / 57 mg hauv 5 ml (457 mg).
Yooj yim pharmacokinetic
| Yam khoom muaj sia | C max (mg / l) | T max (h) | AUC (mg × h / l) |
| Amoxicillin | 6.94±1.24 | 1.13 (0.75-1.75) | 17.29±2.28 |
| Clavulanic acid | 1.1±0.42 | 1 (0.5-1.25) | 2.34±0.94 |
Raws li nrog kev tswj hwm iv ntawm kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid, kev kho mob ntau ntawm amoxicillin thiab clavulanic acid muaj nyob hauv ntau yam plab hnyuv siab raum thiab cov ntaub so ntswg, kua dej interstitial (cov kab mob hauv plab, adipose, pob txha thiab cov leeg nqaij, synovial thiab peritoneal kua, tawv nqaij, kua tsib, thiab purulent tawm) )
Amoxicillin thiab clavulanic acid muaj qhov tsis muaj zog ntawm kev cog lus rau cov ntshav protein. Cov kev tshawb fawb pom tau tias kwv yees li 25% ntawm tag nrho cov nyiaj clavulanic acid thiab 18% ntawm amoxicillin khi rau cov ntshav plasma protein.
Hauv kev tshawb nrhiav tsiaj, qhov kev txuam nrog ntawm cov tshuaj ntawm Augmentin ® tsis pom.
Amoxicillin, zoo li feem ntau penicillins kis mus rau niam mis. Ib co kua nplaum ntawm clavulanic acid kuj tau pom nyob rau hauv niam cov kua mis. Dhau li ntawm qhov ua tau ntawm kev nkag siab, kev txhim kho mob raws plab thiab qhov ncauj plab ntawm lub qhov ncauj ua pa, tsis muaj lwm qhov tsis zoo ntawm amoxicillin thiab clavulanic acid rau kev noj qab haus huv ntawm cov niam mis-pub mis paub. Cov kev tshawb fawb txog kev ua haujlwm ntawm kev ua me nyuam hauv tsiaj pom tias amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv kab mob, tsis muaj qhov tshwm sim tsis zoo ntawm tus me nyuam hauv plab.
10-25% ntawm thawj zaug koob tshuaj amoxicillin yog raug tawm los ntawm lub raum hauv daim ntawv ntawm qhov tsis muaj zog metabolite (penicilloic acid). Clavulanic acid yog dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid thiab 1-amino-4-hydroxy-butan-2-ib thiab tau tawm los ntawm lub raum los ntawm kev zom cov pa zom zaws, ntxiv rau nrog cov huab cua tas sijhawm hauv daim ntawv carbon dioxide.
Zoo li lwm yam penicillins, amoxicillin tsuas yog tawm hauv cov raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab. Li ntawm 60-70% ntawm amoxicillin thiab kwv yees li 40-65% ntawm clavulanic acid raug tso tawm los ntawm lub raum tsis hloov hauv thawj 6 teev tom qab noj 1 lub tshuaj ntawm 250 mg / 125 mg lossis 1 ntsiav tshuaj ntawm 500 mg / 125 mg.
Kev Taw Qhia Augmentin ®
Cov kab mob kis tau los ntawm cov tshuaj lom neeg lub cev tsawg:
- kev kis mob ntawm cov pa ntawm sab saud thiab ENT kabmob (piv txwv li, tonsillitis, mob ua paug, mob otitis media), feem ntau los ntawm Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogenes,
- cov kab mob ua pa tsawg dua: exacerbations ntawm mob ntsws ntev, lobar mob ntsws thiab mob ntsws, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae * thiab Moraxella catarrhalis *,
- mob txeeb zig: cystitis, urethritis, pyelonephritis, kis mob rau poj niam lub cev, ua feem ntau los ntawm hom kab mob Enterobacteriaceae (feem ntau Escherichia coli *), Staphylococcus saprophyticus thiab hom kab mob ntawm genus Enterococcus,
- kab mob gonorrhea mob los ntawm Neisseria gonorrhoeae *,
- kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, feem ntau tshwm sim los ntawm Staphylococcus aureus *, Streptococcus pyogenes thiab hom ntawm cov genus Bactero> * Qee tus neeg sawv cev ntawm cov genus ntawm cov kab mob no ua produce-lactamase, uas ua rau lawv tsis raug rau amoxicillin.
Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin ®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw nquag.
Augmentin ® tseem qhia tau rau kev kho mob sib xyaw ua ke los ntawm cov kab mob me me nkag rau amoxicillin, nrog rau cov kab mob me me uas ua producing-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.
Qhov rhiab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av thiab dhau sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov tsis txaus siab. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.
ICD-10 cov lis dej num| ICD-10 code | Kev taw qhia |
| A54 | Gonococcal mob |
| H66 | Purulent thiab tsis tau hais tawm otitis media |
| J01 | Mob sinusitis |
| J02 | Mob pharyngitis |
| J03 | Mob tonsillitis |
| J04 | Mob laryngitis thiab mob tracheitis |
| J15 | Cov kab mob ntsws mob ntsws, tsis nyob rau lwm qhov |
| J20 | Mob ntsws hawb pob |
| J31 | Mob ntsws hnoos qeev, nasopharyngitis thiab mob pharyngitis |
| J32 | Mob ntsws pob txha ntev |
| J35.0 | Mob ua ntev tonsillitis |
| J37 | Mob ntsws muaj mob thiab mob rau sab hauv lub ntsws |
| J42 | Mob ntsws ntev ntev, tsis pom tseeb |
| L01 | Ncauj Tsis Hnov |
| L02 | Daim tawv ua qog, rwj thiab carbuncle |
| L03 | Phlegmon |
| L08.0 | Pauj Kev Ntsim Siab |
| M00 | Pyogenic mob caj dab |
| M86 | Osteomyelitis |
| N10 | Mob leeg mob ntshav ntswg nephritis mob (mob hlwb pyelonephritis) |
| N11 | Mob leeg txoj hlab ntsws ntev (nephritis) |
| N30 | Cystitis |
| N34 | Kev mob caj pas thiab txoj hlab zis |
| N41 | Cov mob o ntawm lub prostate |
| N70 | Kev mob salpingitis thiab oophoritis |
| N71 | Cov mob o ntawm lub tsev menyuam, tshwj tsis yog rau lub ncauj tsev menyuam (suav nrog endometritis, myometritis, metritis, pyometra, uterine abscess) |
| N72 | Kab mob o (xws li mob ncauj tsev menyuam, mob endocervicitis, exocervicitis) |
| T79.3 | Cov mob tom qab tom qab mob, tsis nyob rau lwm qhov |
Kev noj tshuaj ntxiv
Cov tshuaj tau noj ntawm qhov ncauj.
Cov tshuaj noj rau lub cev yog tsim tshwj xeeb raws lub hnub nyoog, lub cev qhov hnyav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev.
Rau kev nqus zoo thiab txo qis ntawm cov kev mob tshwm sim los ntawm lub plab zom mov, Augmentin ® raug pom zoo kom noj thaum pib noj mov.
Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.
Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.
Yog tias tsim nyog, nws muaj peev xwm los ua kev kho mob staged (thaum pib txoj kev kho, kev tswj hwm kev coj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).
Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua
Nws raug nquahu kom siv lwm cov tshuaj ntawm Augmentin ® lossis kev ncua nrog qhov sib piv ntawm amoxicillin rau clavulanic acid 7: 1 (400 mg / 57 mg hauv 5 ml).
Cov menyuam hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua li 40 kg
Kev suav qhov ntsuas yog ua raws li hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg lub cev qhov hnyav / hnub (xam raws li amoxicillin) lossis hauv ml ntawm kev ncua.
Qhov ntau yam ntawm kev noj ncua kev ncua ntawm 125 mg / 31.25 mg hauv 5 ml yog 3 zaug / hnub txhua 8 teev.
Qhov ntau yam ntawm kev ncua 200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml - 2 zaug / hnub txhua 12 teev.
Cov tshuaj pom zoo ntau npaum li cas thiab kev tswj hwm pes tsawg zaus raug nthuav tawm hauv cov kab hauv qab no.
Augmentin ® ntau npaum cov lus (qhov muab tshuaj rau amoxicillin)
| Kev ntau ntau ntawm kev txais neeg kawm - 3 zaug / hnub Ncua Sijhawm 4: 1 (125 mg / 31.25 mg hauv 5 ml) | Kev ntau ntau ntawm kev nkag - 2 zaug / hnub Ncua Sijhawm 7: 1 (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml) | |
| Tsawg koob tshuaj | 20 mg / kg / hnub | 25 mg / kg / hnub |
| Siab siab | 40 mg / kg / hnub | 45 mg / kg / hnub |
Kev txhaj tshuaj qis ntawm Augmentin ® yog siv los kho cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau ua rau mob tonsillitis.
Kev txhaj tshuaj ntau ntawm Augmentin ® yog siv los kho kab mob xws li mob otitis media, mob siab, mob ntsws qis thiab mob txeeb zig, thiab pob txha thiab mob sib kis.
Muaj cov ntaub ntawv kuaj mob tsis txaus kom pom zoo siv Augmentin ® hauv ib koob ntau dua 40 mg / kg / hnub hauv 3 koob tshuaj sib cais (4: 1 ncua kev kawm) thiab 45 mg / kg / hnub hauv 2 faib tshuaj (7: 1 ncua kev kawm) cov ntaub ntawv tsis txaus siv tshuaj pom zoo kom pom zoo siv koob tshuaj rau cov menyuam yaus hnub nyoog qis dua 2 xyoos.
Cov menyuam txij thaum yug mus txog 3 hlis
Vim lub cev tsis muaj nuj nqi ntawm qhov muaj peev xwm zam ntawm ob lub raum, qhov pom zoo koob ntawm Augmentin ® (xam rau amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj 4: 1.
Kev siv qhov tshem tawm 7: 1 ncua kev kawm (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml) yog contraindicated hauv cov neeg no.
Cov menyuam yug ua ntej
Tsis muaj cov lus qhia hais txog qhov muab tshuaj.
Cov neeg laus cov neeg mob
Tsis tas yuav txhaj ib koob. Hauv cov neeg mob laus uas lub raum lub raum tsis ua haujlwm, qhov koob tshuaj yuav tsum tau kho raws li cov lus qhia rau cov neeg laus uas lub raum tsis ua haujlwm.
Cov neeg mob uas lub raum tsis ua hauj lwm zoo
Kev hloov pauv koob yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin thiab raug kwv yees rau qhov tseem ceeb ntawm QC.
| QC | Ncua Ntawv 4: 1 (125 mg / 31.25 mg hauv 5 ml) |
| > 30 ml / min | Tsis tas yuav tsum kho npaum li cas |
| 10-30 ml / feeb | 15 mg / 3.75 mg / kg 2 zaug / hnub, qhov ntau tshaj yog 500 mg / 125 mg 2 zaug / hnub |
| cov neeg mob mob CC> 30 ml / min, nrog kev kho mob koob tsis tas yuav tsum tau ua. Feem ntau, yog tias ua tau, kev kho mob rau cov niam txiv yuav tsum yog qhov zoo dua. Cov neeg mob Hemodialysis Qhov pom zoo kom noj tshuaj yog 15 mg / 3.75 mg / kg 1 zaug / hnub. Ua ntej kev kho mob hemodialysis, yuav tsum tau txhaj ntxiv 15 mg / 3.75 mg / kg yuav tsum tau muab. Txhawm rau kom rov qab ua kom muaj qhov kub siab ntawm cov tshuaj sib xyaw ntawm cov tshuaj Augmentin ® hauv cov ntshav, koob thib ob ntxiv ntawm 15 mg / 3.75 mg / kg yuav tsum tau siv tom qab kev kho mob hemodialysis. Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua. Tsis muaj cov ntaub ntawv txaus los kho qhov tshuaj ntau npaum li cas hauv pawg neeg mob no. Cov kev cai npaj rau ntawm kev npaj rau kev ncua ntawv Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug. Ncua (125 mg / 31.25 mg hauv 5 ml): ntxiv kwv yees li 60 ml ntawm cov dej rhaub kom txias kom sov rau chav sov mus rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, pub lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias ua tiav kev yug tsiaj. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 92 ml ntawm dej yog xav tau los npaj qhov kev ncua. Ncua (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml): ntxiv kwv yees li 40 ml ntawm cov dej rhaub txias rau chav kub mus rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, muab rau sawv ntsug ntawm lub vial rau 5 feeb kom paub meej kev ua tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 64 ml ntawm dej yog xav tau los npaj qhov kev ncua. Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm qhov ncua kev ncua ntawm Augmentin ® kev npaj yuav tuaj yeem tov nrog dej nyob hauv qhov sib piv ntawm 1: 1. Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov. Sab sij huamCov xwm txheej tsis zoo uas tau nthuav tawm hauv qab no yog teev raws li kev puas tsuaj rau cov kabmob thiab cov nruab nrog cev thiab qhov ntau zaus tshwm sim. Qhov ntau zaus ntawm kev tshwm sim tau txiav txim siab raws li hauv qab no: ntau heev (/1 / 10), feem ntau (≥1 / 100, Kab mob thiab kis kab mob: feem ntau - candidiasis ntawm daim tawv nqaij thiab cov qog ua kua). Los ntawm cov kab mob hemopoietic: tsis tshua muaj - thim rov qab leukopenia (suav nrog neutropenia) thiab thim rov qab thrombocytopenia, tsis tshua muaj tshwm sim - thim rov qab agranulocytosis thiab thim rov qab hemolytic anemia, lub caij nyoog ntawm prothrombin lub sijhawm thiab lub sijhawm los ntshav, ntshav tsis txaus, eosinophilia, thrombocytosis. Los ntawm cov tshuaj tiv thaiv kab mob: tsis tshua muaj tshwm sim - mob hlwb, mob anaphylactic, ib tus mob zoo ib yam li kev mob dej ntshiab, mob vasculitis. Los ntawm cov kab mob hauv lub cev: tsis tuaj yeem - kiv taub hau, mob taub hau, tsis tshua muaj tshwm sim - thim rov qab hyperactivity, convulsions (txiav tau tuaj yeem tshwm sim hauv cov neeg mob uas tsis muaj lub raum tsis ua haujlwm, zoo li hauv cov neeg uas tau txais tshuaj ntau heev), insomnia, ntxhov siab, kev coj tus cwj pwm Cov. Los ntawm cov txheej txheem hauv plab: cov neeg laus: feem ntau - zawv plab, feem ntau - xeev siab, ntuav, menyuam yaus - feem ntau - raws plab, xeev siab, ntuav, tag nrho cov pej xeem: xeev siab yog feem ntau pom thaum noj zoo tshuaj. Yog tias tom qab pib noj cov tshuaj muaj cov tshuaj tsis haum nyob rau ntawm txoj hnyuv, lawv tuaj yeem tshem tawm yog tias koj noj cov tshuaj thaum pib noj mov. Kev mob plab zom mov - lub plab zom zaws, tsis tshua muaj - kab mob sib kis nrog tshuaj tua kab mob los ntawm kev noj tshuaj tua kab mob (suav nrog rau cov mob ua paug thiab mob plab), ua nplaig plaub hau dub, mob plab, mob plab. Hauv cov menyuam yaus, thaum ua ntawv thov kev ncua, qhov cuam tshuam ntawm txheej txheej txheej hniav txha hniav laus yog qhov tsis tshua pom muaj. Nyob rau ib feem ntawm daim siab thiab kab mob hauv lub plab: tsis txaus ntseeg - ib qho kev nce hauv nruab nrab ntawm kev ua ntawm ACT thiab / lossis ALT (pom nyob rau hauv cov neeg mob tau txais beta-lactam tshuaj tua kab mob, tab sis nws cov kab mob tseem ceeb tsis paub), muaj tsawg kawg - kab mob siab thiab mob cholestatic (qhov tshwm sim no tau sau tseg thaum kho nrog lwm tus penicillins thiab cephalosporins), ib qho kev nce siab ntawm bilirubin thiab alkaline phosphatase. Cov kev tshwm sim tsis zoo ntawm daim siab raug pom muaj feem ntau yog rau cov txiv neej thiab cov neeg laus laus thiab yuav muaj feem nrog kev kho mob ntev. Cov xwm txheej tsis zoo no tsis tshua pom muaj hauv cov menyuam yaus. Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, txawm li cas los xij qee zaum qee zaum lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Cov xwm txheej tsis zoo yog cov thim rov qab. Kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, muaj qee qhov tsis tshua muaj neeg ceeb toom kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg uas muaj mob hnyav nrog lub cev lossis cov neeg tau txais cov tshuaj hepatotoxic ib txhij. Los ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: ua haujlwm ntxau - tawm pob, khaus khaus, urticaria, tsis tshua muaj - erythema multiforme, tsis tshua muaj tshwm sim - Stevens-Johnson syndrome, tshuaj lom epidermal necrolysis, ua mob rau sab hauv lub cev, ua kom mob, ua rau mob ua kom zoo. Los ntawm cov hlwv tawm ntawm cov zis: tsis tshua muaj tshwm sim - interstitial nephritis, crystalluria, hematuria. Cov Yuav Tsum Muaj
Ceev faj: lub siab ua haujlwm tsis zoo. Cev xeeb tub thiab lactationHauv kev tshawb nrhiav ntawm kev ua me nyuam hauv tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin ® tsis ua rau muaj teebmeem teratogenic. Hauv txoj kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev xoos xoos, nws tau pom tias kev siv tshuaj kho mob muaj feem cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos yug tshiab. Zoo li txhua yam tshuaj, Augmentin ® tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog tias muaj kev cia siab rau tus niam tshaj qhov muaj feem yuav ua rau muaj menyuam hauv plab. Cov tshuaj Augmentin ® tuaj yeem siv thaum pub mis. Dhau ntawm qhov tshwj xeeb ntawm kev muaj peev xwm tsim kev mob plab zom mov lossis candidiasis ntawm cov kua xoos ntawm lub qhov ncauj kab noj hniav cuam tshuam nrog kev nkag mus rau lub mis niam ntawm cov nyiaj ntawm cov tshuaj xyaw tseem ceeb ntawm cov tshuaj, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos lub mis. Yog tias muaj qhov tshwm sim tsis zoo hauv cov menyuam mos uas tseem noj niam mis, nws yuav tsum tau tsum tsis txhob pub niam mis. Cov lus qhia tshwj xeebUa ntej pib kho nrog Augmentin ®, nws yog ib qho tsim nyog yuav tsum sau ib qho keeb kwm kev kho mob kom zoo txog kev tiv thaiv kab mob yav dhau los rau kev siv penicillins, cephalosporins lossis lwm yam tshuaj uas ua rau muaj kev tsis haum tshuaj ntawm tus neeg mob. Cov mob hnyav, thiab qee zaum kuj ua rau neeg tuag taus, ua kom lub cev tsis haum tshuaj (qhov tsis haum tshuaj muaj txiaj ntsig) rau cov penicillins tau piav qhia. Txoj kev pheej hmoo ntawm cov kev tawm tsam zoo li no yog qhov siab tshaj plaws rau cov neeg mob uas muaj keeb kwm ntawm kev tsis haum lub cev rau penicillins. Yog tias muaj qhov ua xua, nws yuav tsum tsum tsis kho nrog Augmentin ® thiab pib kho lwm txoj kev kho kom haum. Yog tias muaj teeb meem rau qhov mob nyhav dhau los, yuav tsum muab tshuaj rau epinephrine sai sai. Kev kho cov pa oxygen, kev tswj hwm kev tswj hwm ntawm GCS thiab kev pabcuam hauv airway patency, suav nrog kev nkag mus ntxiv, kuj tseem yuav tsum ua. Yog hais tias muaj kev txhawj xeeb ntawm kev kis mob mononucleosis, Augmentin ® yuav tsum tsis txhob siv, vim hais tias nyob rau hauv cov neeg mob tus mob no, amoxicillin tuaj yeem ua rau mob pob khaus zoo li tawv nqaij ua pob, uas ua rau muaj kev cuam tshuam rau kev kuaj mob. Kev kho mob mus ntev nrog Augmentin ® qee zaum ua rau muaj kev tawm tsam ntau ntawm cov kab mob tsis haum. Feem ntau, Augmentin ® tau zam zoo thiab muaj cov yam ntxwv toxicity tsis zoo ntawm txhua tus penicillins. Thaum kho kho nrog Augmentin long lub sijhawm ntev, nws raug nquahu kom ntsuas qee lub sijhawm ua haujlwm ntawm lub raum, mob siab thiab hematopoiesis system. Cov teeb meem ntawm kev tshwm sim ntawm pseudomembranous colitis thaum noj cov tshuaj tua kab mob tau piav qhia, qhov hnyav ntawm uas tuaj yeem sib txawv ntawm mob me me mus rau qhov txaus ntshai ntawm txoj sia. Yog li, nws yog ib qho tseem ceeb uas yuav tsum xav txog qhov ua tau ntawm kev muaj mob ua paug rau cov neeg mob raws plab thaum lub sijhawm lossis tom qab siv tshuaj tua kab mob. Yog tias mob raws plab mus ntev lossis mob hnyav lossis tus neeg mob tau mob plab, yuav tsum tau kho sai sai thiab tus neeg mob yuav tsum kuaj mob. Hauv cov neeg mob uas tau txais kev sib xyaw ntawm amoxicillin nrog clavulanic acid ua ke nrog indirect (qhov ncauj) anticoagulants, hauv qee qhov tsis tshua muaj, kev nce prothrombin lub sijhawm (nce MHO) tau tshaj tawm. Nrog rau kev sib koom tes ntawm kev tiv thaiv kabmob (qhov ncauj) anticoagulants nrog kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev saib xyuas ntawm cov ntsuas tseem ceeb yog qhov tsim nyog. Txhawm rau kom muaj cov nyhuv xav tau ntawm qhov ncauj tshuaj tiv thaiv, yuav tsum tau kho ntau dua koob. Hauv cov neeg mob uas lub raum tsis ua haujlwm, qhov tshuaj ntawm Augmentin ® yuav tsum raug txo kom tsawg. Hauv cov neeg mob nrog txo diuresis, crystalluria tsis tshua muaj tshwm sim, feem ntau nrog kev kho mob kho mob. Nrog kev qhia txog amoxicillin hauv kev txhaj tshuaj siab, nws raug nquahu kom noj cov kua kom txaus thiab tswj cov diuresis kom txo qis qhov muaj feem ntawm kev tsim cov amoxicillin muaju. Thaum noj Augmentin ® sab hauv, cov ntsiab lus ntawm amoxicillin nyob rau hauv cov zis yog pom, uas tuaj yeem ua rau qhov ntsuas tsis zoo hauv kev txiav txim siab cov piam thaj hauv cov zis (piv txwv li Benedict test, Feling test). Hauv qhov no, nws raug nquahu kom siv cov txheej txheem glucose oxidant rau kev txiav txim siab cov ntsiab lus ntawm cov piam thaj hauv cov zis. Clavulanic acid tuaj yeem ua rau qhov tsis muaj tseeb ntawm kev kawm G Gogoglobulin thiab albumin rau erythrocyte daim nyias nyias, uas ua rau muaj qhov tsis zoo ntawm kev kuaj Coombs. Kev tu xyuas hniav yuav pab tiv thaiv kom hniav txhob cuam tshuam nrog kev siv tshuaj, txij li txhuam koj cov hniav tau txaus. Kev quav yeeb quav tshuaj thiab quav yeeb tshuaj Tsis pom muaj kev quav yeeb tshuaj, quav tshuaj thiab kev tsis haum tshuaj cuam tshuam nrog kev siv tshuaj Augmentin ® tau pom. Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab Txij li thaum cov tshuaj yuav ua rau kiv taub hau, nws yog ib qho tsim nyog ceeb toom rau cov neeg mob txog kev ceev faj thaum tsav tsheb lossis ua haujlwm nrog cov tshuab txav. Noj ntau dhauCov tsos mob: lub plab zom mov thiab dej-electrolyte tsis txaus yuav tshwm sim. Amoxicillin crystalluria tau piav qhia, hauv qee kis ua rau kev loj hlob ntawm lub raum tsis ua haujlwm. Qhov ncauj keev tuaj yeem tshwm sim rau cov neeg mob uas lub raum lub raum tsis ua haujlwm, nrog rau cov neeg uas tau txais tshuaj ntau heev. Kev Kho Mob: mob plab zom mov - kev kho mob kom zoo, them nyiaj tshwj xeeb rau kev ua kom dej-electrolyte sib npaug. Yog tias muaj kev noj ntau dhau, amoxicillin thiab clavulanic acid tuaj yeem tshem tawm cov ntshav tawm los ntawm hemodialysis. Cov txiaj ntsig ntawm kev soj ntsuam ib txwm muaj nrog 51 tus menyuam ntawm lub chaw tso tshuaj lom tau qhia tias kev tswj hwm ntawm amoxicillin ntawm koob tshuaj tsawg dua 250 mg / kg tsis tau ua rau cov tsos mob tseem ceeb thiab tsis tas yuav ua kom mob plab. Cov Cai Siv Tshuaj SoNws yog tso rau ntawm lub hwj tshuaj. Augmentin Ncua Kev Kawm Ntau npaum li cas? Tus nqi nruab nrab hauv cov khw muag tshuaj yog ntawm:
Yeeb tshuaj sib cuam tshuamKev siv ua ke ib txhij ntawm cov tshuaj Augmentin ® thiab probenecid tsis pom zoo. Probenecid txo cov tubular ua ke ntawm amoxicillin, thiab yog li ntawd, tib lub sijhawm siv cov tshuaj Augmentin ® thiab probenecide tuaj yeem ua rau nce ntxiv thiab mob siab rau hauv cov ntshav concentration ntawm amoxicillin, tab sis tsis muaj clavulanic acid. Kev siv tib txhij ntawm allopurinol thiab amoxicillin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tawv nqaij ua xua. Tam sim no, tsis muaj cov ntaub ntawv hauv cov ntawv sau ntawm kev siv tib lub sijhawm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid thiab allopurinol. Penicillins tuaj yeem ua kom qeeb ntawm kev siv tshuaj methotrexate los ntawm lub cev los ntawm kev txwv tsis pub nws cov tubular tso pa, yog li ntawd, tib lub sijhawm siv tshuaj Augmentin ® thiab methotrexate tuaj yeem ua rau kom muaj kuab lom ntawm methotrexate. Zoo li lwm yam tshuaj tua kab mob, Augmentin ® kev npaj yuav cuam tshuam rau lub plab hnyuv microflora, ua rau kev txo qis ntawm cov tshuaj estrogen los ntawm kev mob plab thiab txo qis kev ua haujlwm ntawm kev sib xyaw ua ke ntawm qhov ncauj. Cov ntawv nyeem piav qhia feem ntau tsis tshua muaj neeg nce MHO hauv cov neeg mob uas siv cov acenocumarol lossis warfarin thiab amoxicillin. Yog tias nws tsim nyog yuav tsum tau sau ib txhij rau Augmentin ® nrog cov tshuaj tiv thaiv kab mob, lub sijhawm prothrombin lossis MHO yuav tsum ua tib zoo saib xyuas thaum kho lossis hloov Augmentin ®, kev kho tshuaj tiv thaiv kev kho mob rau cov tshuaj tiv thaiv kab mob hauv qhov ncauj yuav tsum tau ua. Hauv cov neeg mob tau txais mycophenolate mofetil, tom qab pib siv kev sib xyaw ntawm amoxicillin nrog clavulanic acid, qhov kev txo qis ntawm cov tshuaj lom neeg metabolite, mycophenolic acid, tau pom ua ntej noj cov tshuaj ntxiv ntawm kwv yees li 50%. Kev hloov pauv hauv qhov kev nkag siab no tsis tuaj yeem cuam tshuam txog qhov hloov pauv ntawm kev cuam tshuam ntawm cov mycophenolic acid. Tso tawm daim ntawv thiab muaj pes tsawg leegCov tshuaj muaj:
Muaj ntau hom:
Hmoov npaj rau kev tsim khoom ntawm kev ncua yog muaj nyob hauv UK (SmithKline Beecham Pharmaceuticals). Cov nyhuv PharmacologicalCov kab mob bacteriolytic yog tau sau tseg. Cov tshuaj yog ua haujlwm hauv aerobic / anaerobic gram-zoo, aerobic gram-tsis zoo cov kab mob. Nws ua tau zoo heev tawm tsam cov hlab ntsha uas muaj peev xwm tsim cov beta-lactamase. Hauv qab ntawm clavulanic acid, tsis kam ntawm amoxicillin rau kev cuam tshuam ntawm ib yam khoom xws li beta-lactamase yog txhim kho. Hauv qhov no, muaj kev nthuav dav ntawm cov nyhuv ntawm cov tshuaj no. Cov tshuaj no nquag tiv thaiv:
Thaum muab tshuaj rau me nyuam, kws kho mob yuav tsum suav qhov uas tsim nyog rau ncua kev muab rau nws. Kev ntsuas rau sivAugmentin tau raug tshaj tawm rau cov kab mob kis tau los ntawm cov kab mob me me uas rhiab rau tshuaj tua kab mob:
Tsis tas li ntawd, cov tshuaj yog siv hauv kev kho, tiv thaiv kev sib kis uas tuaj yeem tshwm sim thaum lub sijhawm ua haujlwm ntawm lub plab zom mov, caj dab, lub taub hau, lub plab, lub raum, pob qij txha, lub siab, lub plab zom mov.
Cov Yuav Tsum MuajTxhua daim ntawv ntau npaum ntawm Augmentin contraindicated rau siv nyob rau hauv muaj cov nram qab no tej yam kev mob los yog kab mob nyob rau hauv ib tug neeg:
Qee cov ntawv cov tshuaj ntawm Augmentin Nyob rau hauv tas li ntawd mus rau lub qhia muaj cov nram qab no ntxiv contraindications: 1. Ncua Kev Kawm 125 / 31.25: 2. Ncua Kev Kawm 200 / 28.5 thiab 400/57:
3. Ntsiav tshuaj ntawm txhua qhov tshuaj (250/125, 500/125 thiab 875/125):
Cov lus qhia rau kev sivCov menyuam yaus hnub nyoog qis dua 12 xyoos lossis muaj lub cev qhov hnyav tsawg dua 40 kg yuav tsum siv Augmentin tsuas yog tshem tawm. Hauv qhov xwm txheej no, cov menyuam mos hnub nyoog qis dua 3 hlis tuaj yeem tsuas yog muab ncua kev kawm ntawv nrog qhov tshuaj ntau npaum li 125 / 31.25 mg. Hauv cov menyuam yaus uas muaj hnub nyoog tshaj 3 hlis, nws tau tso cai siv rau kev ncua nrog ib qho tshuaj ntawm cov khoom nquag. Vim tias qhov tseeb ntawm Augmentin kev ncua kev kawm raug npaj rau cov menyuam yaus, nws ib txwm raug xa mus rau qhov yooj yim xws li "menyuam yaus Augmentin" yam tsis muaj qhov teev daim ntawv noj (ncua kev kawm). Cov tshuaj ntawm qhov ncua kev kawm raug suav txhua tus raws hnub nyoog thiab lub cev qhov hnyav ntawm tus menyuam. Cov lus qhia rau kev siv qhia tias qhov xav tau ntawm qhov kev ncua (kev daws teeb meem) yog ntsuas siv lub khob ntsuas lossis koob txhaj tshuaj. Txhawm rau siv tshuaj rau cov menyuam yaus, koj tuaj yeem sib xyaw cov kev ncua nrog dej, hauv qhov sib piv ntawm ib mus rau ib qho, tab sis tsuas yog tom qab qhov xav tau tshuaj tau kuaj pom.
Txhawm rau suav cov tshuaj ntau npaum li cas, koj yuav tsum siv cov qauv hauv qab no: Ncua 200 mg.
Ncua Sijhawm 400 mg.
Ncua Sijhawm 125 mg.
Kev noj tshuaj ntau npaum li cas tau muab xam nyob ntawm hom mob, theem, chav kawm, qhov hnyav thiab hnub nyoog ntawm tus neeg mob. Nws yuav tsum nco ntsoov tias tsuas yog tus kws kho mob tuaj yeem sau qhov xav tau ntau npaum rau tus neeg mob. Thaum xam xyuas qhov ntau npaum, nws raug nquahu kom txiav txim siab tsuas yog cov ntsiab lus ntawm amoxicillin sodium. Cov kev cai npaj rau ntawm kev npaj rau kev ncua ntawvLub txim yuav tsum npaj ua ntej tam sim ntawd ua ntej siv tshuaj. Cov Cai Ua Noj:
Lub thawv tshuaj yuav tsum tau muab co kom huv ua ntej siv txhua zaus. Txhawm rau kom ntseeg tau qhov ntau thiab tsawg ntawm cov tshuaj, nws raug nquahu kom siv cov ntsuas ntsuas, uas tau ntim hauv cov khoom siv. Lub ntsuas ntsuas yuav tsum tau ua kom huv si tom qab siv txhua zaus. Lub txee lub neej ntawm cov ntawv tshem tawm tiav tsis pub ntev tshaj 1 lub lim tiam hauv lub tub yees. Kev ncua yuav tsum tsis ua kom khov. Rau cov neeg mob uas muaj hnub nyoog qis dua 2 xyoos, tau npaj ib koob tshuaj yuav raug yaj nrog dej rhaub 1: 1. Sab sij huamCov tshuaj tua kab mob yog suav tias muaj kev nyab xeeb rau lub cev ntawm menyuam yaus. Cov tshuaj tau sim rau ntau xyoo, vim qhov no, lub tshuab ntawm nws cov kev coj ua yog qhov zoo kawm. Ib txwm, cov kev mob tshwm sim yuav tshwm sim, tab sis qhov ntxim nyiam ntawm lawv qhov tshwm sim yog qhov tsawg heev.
Cov ua tiav ntawm Augmentin phiv rau cov menyuam tuaj yeem pom nyob rau hauv cov lus qhia rau cov tshuaj. Thiab tseem cov lus qhia rau kev siv muaj ib daim ntawv teev tag nrho cov lus pom zoo thiab ntau npaum li cas los ua ib hom kev siv tshuaj tua kab mob. Txhawm rau tiv thaiv tus me nyuam lub cev los ntawm cov xwm txheej tsis txaus ntseeg no, nws yog qhov yuav tsum tau soj ntsuam xyuas qhov zoo ntawm cov tshuaj los ntawm cov kws tshaj lij. Cia rau cov neeg mob thiab txee lub neejNws raug nquahu kom khaws lub pob muaj tshuaj nyob rau hauv kaum tsev uas cov menyuam yaus yuav tsis ncav cuag. Nws yog qhov tsim nyog los xaiv qhov chaw qhuav, qhov kub nyob hauv nws yuav tsum tsis txhob siab tshaj 25 0 C. Rau 7-10 hnub koj tuaj yeem khaws cov kev ua tiav tiav ntawm qhov kub ntawm 2-8 degrees. Ib txoj hauv kev daws rau kev txhaj tshuaj rau txoj leeg yuav tsum siv tam sim tom qab npaj.
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