Noliprel Ib Fort > Kev khomob thiab kev tiv thaiv

Lub npe Latin: Noliprel A forte

ATX Code: C09BA04

Cov khoom xyaw nquag: perindopril arginine (perindopril arginine) + indapamide (indapamide)

Cov chaw tsim khoom: Lub chaw soj nstuam Servier Kev Lag Luam (Fabkis), Serdix, LLC (Russia)

Hloov kho cov lus piav qhia thiab yees duab: 11/27/2018

Cov nqi hauv khw muag tshuaj: los ntawm 564 rubles.

Noliprel A forte yog cov tshuaj sib xyaw ua ke, nrog rau cov tshuaj angiotensin hloov kho enzyme inhibitor (ACE) thiab diuretic.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov yeeb yaj kiab-cov ntsiav tshuaj: oblong, dawb (hauv polypropylene fwj nrog dispenser: 14 lossis 29 pcs., Hauv ib lub thawv ntawv cardboard nrog thawj qhib tswj 1 lub raj mis, 30 pcs., Hauv ib lub thawv ntawv cardboard nrog thawj qhib tswj 1 lossis 3 lub raj mis, hauv pob khoom rau tsev kho mob - 30 lub raj mis hauv daim ntawv ntoo, hauv ntawv thawv ntawv 1 pallet thiab cov lus qhia rau kev siv Noliprel A forte).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: perindopril arginine - 5 mg (sib npaug rau cov ntsiab lus ntawm 3.395 mg perindopril), indapamide - 1,25 mg,
Cov khoom siv pabcuam: lactose monohydrate, colloidal silicon dioxide anhydrous, maltodextrin, sodium carboxymethyl hmoov txhuv nplej siab (hom A), magnesium stearate,
zaj duab xis txheej muaj pes tsawg leeg: premix rau txheej dawb zaj duab xis txheej SEPIFILM 37781 RBC hypromellose, macrogol 6000, glycerol, titanium dioxide (E171), magnesium stearate, macrogol 6000.

Cov tshuaj "Noliprel forte": muaj pes tsawg leeg thiab daim ntawv ntawm kev tso tawm

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated nrog tiv thaiv zaj duab xis. Cov tshuaj no suav nrog ntau cov tshuaj yeeb dej caw ntawm ib zaug, uas muab nws cov nyhuv ua ke. Hauv tshwj xeeb, txhua ntsiav tshuaj muaj 10 mg perindopril arginine (qhov nyiaj no sib piv rau 6.79 mg perindopril) thiab 2.5 ml indapamine.

Hauv kev tsim cov tshuaj, tshuaj yeeb tshuaj xws li magnesium stearate, colloidal anhydrous silicon dioxide, lactose monohydrate, maltodextrin, hypromellose, macrogol 6000, glycerol thiab qee lwm tus kuj tseem siv los ua cov neeg sawv cev tiv thaiv kab mob.

Pharmacological cov yam ntxwv ntawm cov tshuaj

Yog lawm, thaj chaw ntawm cov tshuaj "Noliprel forte" muaj feem cuam tshuam nrog kev cuam tshuam rau lub cev ntawm nws cov khoom sib txuas. Tab sis rau cov pib, nws tsim nyog sau cia tias cov tshuaj muaj suab nrov hypotensive, thiab cuam tshuam ob qho systolic thiab diastolic siab. Qhov loj ntawm cov nyhuv hauv qhov no nyob ntawm lub koob tshuaj. Cov txiaj ntsig pheej tshwm sim tsis ntev dua ib hlis tom qab pib kho mob.

Perindopril yog ib qho tseem ceeb ntawm cov tshuaj. Cov tshuaj no yog qhov inhibitor ntawm qee yam ntawm enzyme. Nws dilates cov hlab ntsha thiab rov kho tus qauv ntawm lawv cov phab ntsa. Ntau cov kev tshawb fawb tau pom tias perindropril txo cov ntshav siab, thiab kev tshem tawm tshuaj tsis ua rau muaj kev cuam tshuam zoo. Lwm cov tshuaj nquag, indapamide, zoo ib yam hauv nws lub zog rau thiazide diuretics. Qhov kev tiv thaiv no txwv qhov kev nqus ntawm potassium ions nyob rau hauv lub nephron, uas ua rau kom ntau dua diuresis thiab kev tso tawm ntawm cov tshuaj chlorine thiab sodium ions nrog tso zis.

Perindopril ua tawm hauv cov zis. Nws qhov siab tshaj plaws tau pom nyob 3-4 teev tom qab tswj hwm. Raws li rau indapamide, nws pib ua kom nquag plias tom qab ib teev, thiab nws tawm nrog rau cov zis thiab quav.

Cov Tshuaj Hauv Tshuaj

Noliprel A forte yog qhov tshuaj tiv thaiv hypotensive, cov nyhuv ntawm uas yog vim muaj cov khoom tiv thaiv kab mob ntawm perindopril thiab indapamide, txhim kho ntxiv los ntawm lawv cov kev sib txuam.

Perindopril yog ACE inhibitor uas yog lub luag haujlwm rau kev hloov pauv ntawm angiotensin I mus rau vasoconstrictor substance angiotensin II. Ntxiv rau, ACE (lossis kininase II) hloov bradykinin rau hauv kev tso tshuaj heptapeptide. Bradykinin hauv lub cev muaj cov nyhuv vasodilating. Raws li qhov txiaj ntsig ntawm ACE kev tiv thaiv, kev zais cia ntawm aldosterone poob qis, cov txheej txheem kev xav tsis zoo pib, uas ua rau muaj kev ua si renin hauv cov ntshav ntshav. Vim tias qis dua preload thiab tom qab thauj, myocardial muaj nuj nqi yog ib txwm muaj. Kev siv ntev ntev ntawm perindopril pab txo kom tag nrho cov kev tiv thaiv kev mob ntshav ntawm lub cev (OPSS), uas yog vim nws cov nyhuv rau cov hlab ntsha hauv cov leeg thiab lub raum. Cov teebmeem tau tiav yam tsis muaj kev ncua ntev ntawm sodium thiab kua ions lossis kev txhim kho ntawm reflex tachycardia.

Nws tau tsim los lawm tias yog tias muaj kev mob plawv tsis txaus (CHF), perindopril muab qhov txo qis hauv kev ua kom lub siab ntawm lub plawv sab laug thiab txoj hlab ntsws, txo qis hauv lub plawv dhia, nce siab ntxiv rau cov txiaj ntsig ntawm lub plawv thiab nce ntshav tawm ntawm cov leeg ntshav.

Indapamide yog sulfonamide uas nws cov tshuaj pharmacological zoo ib yam li thiazide diuretics. Nws inhibits reabsorption ntawm sodium ions nyob rau hauv lub cortical ntu ntawm Henle lub voj voos, ua rau muaj kev cuam tshuam ntau ntawm chloride, sodium, thiab kom tsawg dua li cov magnesium thiab potassium ions los ntawm ob lub raum. Qhov no nce diuresis thiab ua rau txo qis ntshav siab (BP).

Qhov ua hauj lwm los tiv thaiv kev loj ntawm Noliprel A forte yog koob tshuaj-qhov nyob ntawm qhov xwm txheej, thaum sawv thiab dag nws yog sib npaug sib xyaw ua piv rau diastolic thiab systolic ntshav siab. Tom qab noj cov tshuaj, cov nyhuv ntawm cov tshuaj tseem mob rau 24 teev. Kev kho mob ua kom tiav mus txog ruaj ntseg tom qab 30 hnub ntawm kev kho mob.

Discontinuation ntawm kev kho tsis yog nrog los ntawm ntsoos ntsoos mob.

Nrog rau kev siv Noliprel A forte, muaj kev txo qis OPSS, qhov txo qis hauv kev kawm ntawm sab laug ventricular hypertrophy (GTL), thiab kev txhim kho ntawm kev ywj pheej ntawm cov hlab ntsha. Cov tshuaj tsis cuam tshuam rau cov metabolism ntawm lipids thiab cov ntsiab lus ntawm cov roj (cholesterol), cov roj (cholesterol), cov lipoprotein ntau ntau (HDL) thiab muaj lipoprotein tsawg (LDL) lossis triglycerides.

Nrog rau cov hlab ntsha txhaws thiab GTL, nyob rau hauv cov ntaub ntawv ntawm kev sib xyaw ntawm perindopril thiab indapamide, qhov tseem ceeb dua nyob rau sab laug ventricular pawg index (LVMI) thiab cov txiaj ntsig antihypertensive tau pom piv nrog enalapril.

Kev kawm txog cov txiaj ntsig ntawm Noliprel A Forte ntawm lub ntsiab loj macro- thiab microvascular cov teeb meem hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus tau coj los ntxiv rau ob qho tib si kev kho mob rau glycemic tswj thiab kev paub zoo glycemic tswj (IHC) lub hom phiaj (phiaj HbA_1c tsawg dua 6.5%). Ib pab pawg ntawm cov neeg mob tau koom nrog txoj kev tshawb fawb, qhov ntsuas nruab nrab ntawm uas yog: hnub nyoog 66 xyoo, ntshav siab - 145/81 hli Hg, qhov hnyav nyhav ntawm qhov ntsuas - 28 kg ib 1 m 2 ntawm lub cev, HbA1c (glycosylated hemoglobin) - 7.5%. Cov neeg mob feem ntau tau nyob ntawm hypoglycemic thiab concomitant kho (suav nrog antihypertensive, hypolipidemic, antiplatelet agents).

Cov ntsiab lus tshawb pom (lub sijhawm soj ntsuam tau kwv yees li 5 xyoo) tau qhia txog kev txo qis li 10% ntawm kev pheej hmoo ntawm kev sib xyaw ntawm cov kab mob sib xyaw ua ke loj-thiab cov teeb meem me me hauv IHC pawg (nruab nrab HbA_1c 6.5%) piv nrog pab pawg tswj hwm (nruab nrab HbA_1c 7,3%).

Kev txo qis hauv kev pheej hmoo ntawm kev txheeb ze raug txheeb ze rau kev txo qis ntawm 14% hauv cov teeb meem microvascular lub ntsiab, 21% rau kev tshwm sim thiab kev loj hlob ntawm nephropathy, 9% rau microalbuminuria, 30% rau macroalbuminuria, thiab 11% rau kev txhim kho cov mob raum.

Cov txiaj ntsig ntawm kev kho mob tsis txaus ntseeg tsis yog nyob ntawm cov txiaj ntsig tau ua tiav nrog IHC.

Cov nyhuv antihypertensive ntawm perindopril yog qhov paub tseeb rau kev kho mob ntawm txoj kev mob ntshav ntawm txhua qhov mob. Tom qab ib qho kev tswj hwm qhov ncauj nkaus xwb, cov txiaj ntsig siab tshaj plaws ntawm Noliprel A Forte tau tiav tom qab 4-6 teev thiab kav rau 24 teev. Tshaj tawm qhov seem (li 80%) inhibition of ACE raug pom nyob 24 teev tom qab nws tswj hwm.

Perindopril muaj cov nyhuv hypotensive nrog rau kev ua haujlwm qis thiab ntshav ntshav tsawg dua.

Kev sib xyaw nrog thiazide diuretics ua rau muaj kev cuam tshuam ntawm cov nyhuv antihypertensive, txo qis kev pheej hmoo ntawm hypokalemia vim qhov kev nqus ntawm diuretics.

Kev kho kev sib xyaw ua ke nrog ACE inhibitor thiab angiotensin II receptor antagonist (ARA II) hauv cov neeg mob uas muaj keeb kwm mob plawv los yog mob ntshav qab zib, cov neeg mob ntshav qab zib hom 2 (nrog paub tseeb lub hom phiaj ua paug), hom 2 mob ntshav qab zib thiab ntshav qab zib tau tsis tau saib mob muaj cov txiaj ntsig zoo rau qhov tshwm sim ntawm lub raum thiab / lossis cov hlab plawv lossis cov kev tuag. Tab sis tom qab muab piv nrog kev kho mob monotherapy, nws tau pom tias tiv thaiv keeb kwm yav dhau los ntawm kev sib xyaw ntawm ACE inhibitor thiab ARA II, qhov kev pheej hmoo ntawm kev tsim mob hyperkalemia, mob raum tsis ua haujlwm thiab / lossis arterial hypotension nce.

Coj mus rau hauv tus account tias intragroup pharmacodynamic zog ntawm ACE inhibitors thiab ARA II zoo sib xws, cov txiaj ntsig no tuaj yeem xav tau nrog kev sib txuas ntawm perindopril thiab ARA II.

Nws tsis pom zoo kom siv ACE inhibitors thiab ARA II hauv cov neeg mob uas mob nephropathy.

Kev ntxiv ntawm aliskiren mus rau hom 2 mob ntshav qab zib mellitus thiab mob raum thiab / lossis cov hlab plawv mus rau cov qauv ACE lossis ARA II inhibitor txoj kev kho ntxiv nce qhov kev pheej hmoo ntawm cov txiaj ntsig tsis zoo, suav nrog kev mob plawv tuag, mob ntshav hlab, kev loj hlob ntawm hyperkalemia, arterial hypotension thiab lub raum tsis ua haujlwm. Cov.

Kev siv cov indapamide hauv cov tshuaj uas muaj cov nyhuv diuretic tsawg heev ua rau txo OPSS, txhim kho cov khoom ywj pheej ntawm cov hlab ntsha loj, uas muab nws nrog cov nyhuv antihypertensive. Tsis tas cuam tshuam txog qib ntawm lipids hauv cov ntshav plasma (triglycerides, cov roj (cholesterol) tag nrho, LDL, HDL) thiab cov metabolism hauv kev noj haus (nrog rau cov neeg mob ntshav qab zib mellitus), indapamide pab txo GTL.

Cov Tshuaj Pharmacokinetics

Tus yam ntxwv pharmacokinetic muaj nyob rau hauv monotherapy nrog txhua yam ntawm cov tshuaj tsis hloov nrog kev sib xyaw ntawm perindopril thiab indapamide.

Tom qab kev tswj hwm ntawm qhov ncauj, perindopril nqus tau tshwm sim sai, nws txoj kev siv xyoob ntoo tuaj yeem muaj li ntawm 65 txog 70%. Kwv yees li 20% ntawm qhov nqus tau cov tshuaj yog biotransformed rau hauv cov nquag metabolite perindoprilat. Nws qhov siab tshaj plaws (C_max) hauv cov ntshav ntshav tau mus txog tom qab 3-4 teev. Concurrent ingestion txo qhov kev hloov pauv ntawm perindopril rau perindoprilat tsis muaj qhov cuam tshuam tseem ceeb hauv kev kho mob.

Tom qab nqus sai sai ntawm indapamide los ntawm kev mob plab hnyuv tag nrho hauv qhov kev noj tshuaj, nws C_max nyob rau hauv cov ntshav ntshav tau mus txog hauv 1 teev txij li lub sijhawm khoom noj haus.

Plasma protein khi: perindopril - tsawg dua 30%, indapamide - 79%.

Kev cuam tshuam ntawm ACE-ntsig txog perindoprilat qeeb, yog li ntawd, muaj txiaj ntsig ib nrab-lub neej (T_1/2) perindopril - 25 teev. Lub xeev kev sib luag yog mus txog tom qab 96 teev.

Perindopril hla lub teeb meem chaw.

Kev nquag noj ntawm Noliprel A forte tsis ua rau kom muaj zog hauv lub cev ntawm nws cov khoom siv nquag.

Perindoprilat ua tawm los ntawm ob lub raum, T_1/2 Nws yog 3-5 teev.

T_1/2 indapamide nruab nrab 19 teev. Nws yog tawm hauv daim ntawv ntawm tsis muaj zog metabolites: dhau los ntawm ob lub raum - 70% ntawm qhov koob tshuaj, los ntawm txoj hnyuv - 22%.

Kev tshem tawm ntawm perindoprilat thaum lim ntshav yog 70 ml / min.

Nrog lub raum thiab lub plawv tsis ua haujlwm, nrog rau cov neeg mob laus, qhov kev nthuav dav ntawm perindoprilat qeeb qeeb.

Nrog cov mob ntsws ua rau lub siab, kho cov pob khaus kho ntawm perindopril raug txo qis 2 zaug, tab sis qhov no tsis cuam tshuam qhov nyiaj ntawm perindoprilat, yog li tsis tas kho qhov koob tshuaj.

Hauv cov neeg mob uas mob raum tsis ua haujlwm, cov chaw muag tshuaj ntawm indapamide tsis hloov.

Cov Yuav Tsum Tau Ua

mob rau daim siab ua hauj lwm siab, suav nrog cov nyom los ntawm encephalopathy,
mob raum tsis ua haujlwm nrog creatinine kev tshem tawm (CC) tsawg dua 30 ml / min,
ob leeg lub raum leeg mob stenosis,
muaj ib lub raum hauj lwm,
kev siv ntawm hemodialysis,
hypokalemia
Yog tsis kho kho lub plawv tsis ua haujlwm,
concomitant kho nrog cov tshuaj uas txuas ntxiv QT ntu sij hawm,
ua ke nrog nrog cov tshuaj tiv thaiv tsis zoo uas tuaj yeem ua rau ventricular arrhythmias xws li "pirouette",
tib lub sij hawm siv nrog cov tshuaj uas muaj aliskiren hauv cov neeg mob ntshav qab zib mellitus lossis lub raum tsis ua haujlwm (GFR tsawg dua 60 ml / min rau 1.73 m2 ntawm lub cev nqaij daim tawv hauv cheeb tsam),
Cov piam thaj-galactose malabsorption syndrome, galactosemia, lactase deficiency,
roj ntsha lossis idiopathic angioedema,
qhov qhia txog keeb kwm ntawm kev mob caj dab, nrog rau kev siv ACE inhibitors,
cev xeeb tub lub sijhawm
pub niam mis
hnub nyoog txog 18 xyoo
teeb tsa kev ua haujlwm siab rau lwm yam ACE inhibitors lossis sulfonamides,
kev tsis qaug rau lub zog ntawm cov tshuaj.

Nrog kev ceev faj, nws tau pom zoo tias Noliprel A forte raug muab rau cov neeg mob uas mob plawv tsis ua haujlwm ntawm lub plawv tsis ua haujlwm ntawm qib IV ua haujlwm raws li NYHA kev faib tawm (New York Lub Plawv Cov Koom Tes), angina pectoris, kev kho mob ntshav txhaws, aortic valve stenosis, hypertrophic obstructive cardiomyopathy, txo pob txha hlwb (ntshav tsawg) (suav nrog kev noj tshuaj pab, ua raws ntsev noj, kom ntuav, raws plab lossis tso ntshav), cerebrovascular abolevaniyami, mob ntshav qab zib, daim siab tsis ua hauj lwm, mauj connective cov ntaub so ntswg mob (xws li scleroderma, mauj lupus erythematosus), nrog rau cov lability ntawm cov ntshav siab, hyperuricemia (tshwj xeeb tshaj yog nrog urate gout thiab nephrolithiasis), nyob rau hauv cov neeg laus, raws li zoo raws li kev ncaws pob thiab cov neeg mob dub.

Tsis tas li ntawd, nws raug nquahu kom siv kev ceev faj nrog kev siv tshuaj tiv thaiv kab mob sib kis, kev npaj tshuaj lithium, hemodialysis siv lub tshuab ua pa ntawm lub cev siab, desensitization, nyob rau lub sijhawm ua ntej LDL apheresis cov txheej txheem, tshuaj loog, thiab hloov raum.

Sab sij huam

los ntawm lub hauv nruab nrab hauv lub paj hlwb: feem ntau - mob taub hau, mob duav, kiv taub hau, kiv taub hau, mob caj dab, mob khaub thuas, ua tsis xws luag - lub siab lub zog, pw tsis taus, tsis tshua muaj tshwm sim - tsis meej pem, ntau zaus tsis tsim - tsaus muag,
los ntawm cov kab mob lymphatic thiab cov ntshav ncig: tsis tshua muaj - leukopenia, neutropenia, thrombocytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, anemia (tom qab hloov raum, hemodialysis),
los ntawm cov hlab plawv: feem ntau - lub cim txo qis ntshav siab (suav nrog orthostatic hypotension), tsis tshua muaj tshwm sim - mob plawv dhia tsis xws luag (suav nrog rau bradycardia, ventricular tachycardia, atrial fibrillation), angina pectoris, myocardial infarction, zaus tsis tau tsim - pirouette hom arrhythmia, suav nrog neeg tuag taus,
los ntawm cov kabmob hauv nruab nrog cev: feem ntau - tinnitus, lub qhov muag pom tsis zoo,
los ntawm kev ua pa, hauv siab thiab mediastinal plab hnyuv siab raum: feem ntau - hnoos qhuav siv sij hawm (vim siv sij hawm ntev ntawm perindopril), ua tsis taus pa luv, ua tsis taus pa - bronchospasm, tsis tshua muaj - rhinitis, eosinophilic mob ntsws,
los ntawm kev mob plab zom mov: feem ntau - ua txhaum ntawm saj, lub qhov ncauj qhuav, qab los noj mov, xeev siab, ntuav, mob epigastric, mob plab, cem quav, raws plab, dyspepsia, tsis tshua muaj - pancreatitis, angioedema, cholestatic jaundice, cytolytic lossis cholestatic mob siab, qhov ntau zaus tsis tsim - hepatic encephalopathy (nrog rau daim siab ua kom lub siab tsis ua haujlwm),
kev tawm tsam: ua tsis haum - urticaria, angioedema ntawm lub ntsej muag, daim di ncauj, tus nplaig, nqua, cov leeg ntawm lub suab quav thiab / lossis lub suab ntawm lub suab, yog qhov ua rau pom kev txhaus rau lub ntsws thiab ua kom tsis haum - ua kom lub cev tsis haum,
dermatological tshua: feem ntau - khaus, tawv nqaij ua pob, maculopapular tawm pob, tsis tshua muaj - kev phem ntawm qhov mob hnyav ntawm kev mob ntawm cov kab mob lupus erythematosus, purpura, tsis tshua muaj tshwm sim - lom kabmob ua mob lom hauv lub cev, erythema multiforme, Stevens-Johnson syndrome, kev sib deev,
los ntawm cov leeg ua haujlwm: feem ntau - mob leeg nqaij,
los ntawm kev muaj me nyuam: ncaav - impotence,
los ntawm cov kab mob urinary: pheej: raum tsis ua hauj lwm, tsis tshua muaj heev - mob raum tsis ua hauj lwm,
cov cim ntsuas: tsis tshua muaj - hypercalcemia, qhov zaus tsis tau tsim - kev nce hauv QT ntu ntawm electrocardiogram, nce qib ntawm cov piam thaj thiab uric acid nyob rau hauv cov ntshav, kev nce siab hauv kev ua haujlwm ntawm daim siab enzymes, hypokalemia, hyponatremia, hypovolemia, hyperkalemia, nce ntxiv hauv cov ntshav ntawm creatinine plasma hauv ntshav
cov kev tawm tsam dav dav: feem ntau - asthenia, tsis xws luag - tawm hws.

Noj ntau dhau

Cov tsos mob: lub cim txo qis rau cov ntshav siab, uas yog nrog los ntawm xeev ntuav, ntuav, kiv taub hau, tsaug zog, cramps, tsis meej pem, oliguria, qee zaum tig mus rau hauv anuria vim los ntawm hypovolemia, ua tsis tau dej-electrolyte tshuav (hyponatremia thiab hypokalemia).

Kev Kho Mob: kev mob plab sai sai, kev teem sijhawm ntawm cov pa roj carbon activated, rov ua kom dej-electrolyte tshuav nyiaj. Nrog hypotension hnyav, tus neeg mob yuav tsum muab tso rau ntawm nws sab nraub qaum thiab ob sab ceg sawv. Txhawm rau kom paub tseeb txog kev saib xyuas ntawm tus neeg mob, nrog hypovolemia - txhawm rau nqa iv (infusion) Txoj kev lis ntshav ntawm 0.9% sodium chloride tov.

Tej zaum yuav siv cov tshuaj lim ntshav.

Cov lus qhia tshwj xeeb

Kev siv ntawm Noliprel A forte yog nrog cov kev mob tshwm sim uas cuam tshuam nrog kev kho mob monotherapy nrog perindopril thiab indapamide ntawm kev kho mob qis tshaj plaws. Hauv cov neeg mob uas tsis tau yav tas los tau txais kev kho nrog ob yam tshuaj tiv thaiv kabmob ntshav, muaj kev pheej hmoo ntxiv ntawm idiosyncrasy, thiab yog li ntawd yuav tsum tau ua tib zoo saib xyuas kom txo cov kev pheej hmoo no.

Yog tias pom cov cim ntawm lub raum tsis ua haujlwm tau pom thaum kho, kev kho mob nrog cov tshuaj yuav tsum tau tsum txuas mus ntxiv. Txhawm rau rov pib kho txoj kev kho kom zoo, nws raug nquahu kom siv cov tshuaj tsawg kawg ntawm ib qho tshuaj lossis mus kho tsuas yog ib qho ntawm lawv. Hauv qhov xwm txheej no, cov neeg mob xav tau soj ntsuam cov poov tshuaj poov tshuaj thiab cov qib creatinine tsis tu ncua. Cov kev tshawb fawb tau coj 14 hnub tom qab pib kho thiab tom qab ntawd 1 zaug hauv 60 hnub.

Hauv cov neeg mob uas muaj mob plawv heev thiab lub raum tsis ua haujlwm zoo (suav nrog lub raum leeg ntshav hlab plawv), lub raum tsis ua haujlwm feem ntau tshwm sim.

Kev tsim kho tshiab ntawm txoj hlab ntaws hypotension feem ntau yog nrog thawj zaug hyponatremia, tshwj xeeb tshaj yog nyob rau cov neeg mob mob raum leeg mob stenosis. Yog li, tom qab zawv plab los yog ntuav, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv tus account ua kom lub cev qhuav dej thiab txo qis hauv cov roj ntsha hauv cov ntshav ntshav. Nrog rau txoj kev mob ntshav ntau heev, txoj kev tswj hwm ntawm 0.9% sodium chloride tov yog qhia.

Kev hloov pauv ntawm txoj hlab ntsha tsis yog ib qho laj thawj rau kev kho kom tsis tu ncua. Tom qab kho rov qab los ntawm BCC thiab ntshav siab, kev kho mob tuaj yeem siv rov qab siv qhov qis ntawm ob lub nquag lossis ib qho ntawm cov tshuaj.

Txoj kev kho yuav tsum nrog soj ntsuam cov poov tshuaj ntau nyob hauv cov ntshav ntshav, tshwj xeeb tshaj yog muaj ntshav qab zib mellitus thiab lub raum tsis ua haujlwm.

Kev siv Noliprel A Fort yuav tsum tau tsum txiav 24 teev ua ntej pib desensitization.

Ua ntej txhua qhov txheej txheem LDL apheresis siv cov dextran sulfate, kev tswj hwm ntawm ACE inhibitor yuav tsum tsis ua mus ib ntus.

Hauv cov neeg mob kho mob perindopril, kev siv lub tshuab nqus dej siab tuaj yeem siv tsis tau thaum lub sijhawm mob hemodialysis. Lawv yuav tsum tau hloov los ntawm lwm lub qog lossis lwm txoj kev kho tshuaj tiv thaiv kab mob siab yuav tsum yog tus neeg mob siv cov tshuaj ntawm lwm pab pawg kws kho mob.

Hauv kev txheeb xyuas ntawm kev hnoos qhuav tsis tu ncua uas tau sawv thaum kho, nws yuav tsum tau yug hauv siab tias kev siv tshuaj ACE inhibitor yuav yog qhov ua rau nws qhov tsos.

Vim tias muaj kev pheej hmoo siab ntawm kev tsim tus mob neutropenia, agranulocytosis, thrombocytopenia, thiab ua kom yuag ntshav siab, yuav tsum tau saib xyuas tshwj xeeb thaum kho tus mob perindopril rau cov neeg mob uas muaj cov kab mob ntawm cov nqaij sib txuas, noj ob qho tshuaj tiv thaiv kab mob, procainamide lossis allopurinol, tshwj xeeb tshaj yog thaum xub thawj lub raum tsis ua haujlwm. Cov neeg mob no yog cov muaj pheej hmoo loj los tsim kev mob hnyav, feem ntau muaj peev xwm tiv taus cov tshuaj tua kab mob hnyav. Kev siv Noliprel A Forte hauv pawg neeg mob no raug pom zoo kom nrog kev tshuaj xyuas ib ntus ntawm cov lej ntawm cov leukocytes hauv cov ntshav. Lawv yuav tsum raug qhia paub txog qhov xav tau tam sim ntawd sab laj nrog kws kho mob yog tias muaj mob caj pas, ua npaws thiab lwm cov tsos mob ntawm tus kab mob sib kis.

Nrog ib qho kev txo qis hauv cov ntshav ntshav electrolytes thiab cov ntshav hypovolemia ntau heev, thaum ntxov tsis tshua muaj ntshav siab, lub raum leeg ntshav txhaws, mob plawv tsis ua hauj lwm, lossis kab mob siab mus rau lub siab nrog edema thiab ascites, ua haujlwm tseem ceeb ntawm renin-aldosterone-angiotensin system (RAAS) tej zaum yuav tshwm sim vim qhov thaiv ntawm cov kab mob no los ntawm perindopril. Tus neeg mob tej zaum yuav nrog ua ke los ntawm cov ntshav siab, qhov nce ntawm creatinine hauv ntshav ntshav, kev txhim kho ntawm lub raum ua haujlwm tsis ua haujlwm. Feem ntau, cov xwm txheej no tau pom nyob hauv thawj 14 hnub ntawm kev kho. Nws raug nquahu kom rov pib noj cov tshuaj nrog rau qis dua.

Txog kev mob ntshav siab hauv cov neeg mob uas muaj mob plawv (CHD), kev tsis txaus ntseeg cerebrovascular tsis txaus, lub plawv tsis ua haujlwm hnyav thiab / lossis ntshav qab zib hom 1, kev kho yuav tsum pib nrog cov koob tshuaj qis. Cov neeg mob uas muaj mob ua mob rau cov hlab ntshav yuav tsum coj ACE inhibitors nrog rau beta-blockers.

Vim txoj kev pheej hmoo ntawm kev tsim muaj ntshav khov hauv cov neeg mob uas tau hloov raum lossis tso cov ntshav hloov kho, hloov kho yuav tsum nrog cov ntshav kuaj ntshav.

Ua ntej kev phais mob ntau, Noliprel A Fort yuav tsum tsum tsis txhob txiav 24 teev ua ntej pib kev tso tshuaj kom tsaug zog.

Nws yuav tsum tau yug hauv siab tias hauv cov neeg mob ntawm cov haiv neeg Negroid, cov nyhuv antihypertensive ntawm perindopril yog tsawg tshaj tawm.

Yog tias daim siab ua haujlwm tsis zoo, indapamide tuaj yeem ua rau kev txhim kho hepatic encephalopathy, yuav tsum tau txiav tawm cov tshuaj tam sim ntawd.

Teem sij hawm ntawm Noliprel A forte yuav tsum tau ua rau suav txog qhov txiaj ntsig ntawm kev kawm txog kev tshawb fawb ntawm cov dej-electrolyte sib npaug (suav nrog cov ntsiab lus ntawm sodium, potassium thiab calcium ions hauv cov ntshav ntshav) ntawm tus neeg mob, tom qab uas kev kuaj ntshav kuaj mob tseem ceeb.

Hypokalemia hauv cov neeg laus laus, cov neeg mob tsis zoo, cov neeg mob lub plawv tsis ua haujlwm, mob plawv, mob ntsws (nrog rau edema lossis ascites) txhim kho cov tshuaj lom ntawm cov kab mob glycosides thiab nce kev pheej hmoo ntawm arrhythmias.

Thaum lub sij hawm kho cov diuretic, ua kom ntshav ntshav uric acid ntau ntau yuav ua rau muaj kev tiv thaiv gout.

Kev ua tau zoo ntawm kev kho nrog thiazide thiab thiazide zoo li diuretics tuaj yeem lav tau nkaus xwb nrog kev ua haujlwm zoo li qub los yog qias neeg me me. Lub plasma creatinine concentration hauv cov neeg mob laus yuav tsum qis dua 2.5 mg / dL lossis 220 μmol / L. Rau cov neeg laus laus, nws tau kho kom haum rau lub hnub nyoog, tub thiab ntxhais, thiab hnyav uas siv cov qauv Cockcroft. Kev ntsuas tus qauv ntawm plasma creatinine concentration hauv cov txiv neej yog txiav txim siab los ntawm qhov sib txawv (140 feeb ntawm lub hnub nyoog) los ntawm tus neeg mob lub cev nyhav thiab faib tawm qhov tshwm sim los ntawm plasma creatinine concentration (μmol / L), khoo 0.814. Txhawm rau txiav txim siab rau qhov ntsuas no rau cov poj niam, qhov kawg tshwm sim yuav tsum muab khoo nrog 0.85.

Rau cov neeg mob uas lub raum tsis ua haujlwm, qhov tshwm sim ntawm kev hloov raum tsis ua haujlwm tsis txaus ntshai. Nrog rau lub raum tsis ua haujlwm thawj zaug, txo qis hauv GFR, kev nce ntawm urea thiab creatinine hauv ntshav ntshav tuaj yeem muaj tus cwj pwm tshaj tawm thiab muaj kev rau txim loj.

Vim tias qhov kev pheej hmoo ntawm qhov kev hloov pauv hloov lub zog thaum siv Noliprel A Forte, nws raug nquahu kom tsis txhob raug tshav ncaj qha lossis hluav taws xob ultraviolet.

Nws yuav tsum tau yug los hauv lub siab tias thaum coj kev tswj hwm lub cev muaj zog hauv cov kis las, indapamide tuaj yeem ua rau muaj kev cuam tshuam zoo.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Noliprel A forte tsis ua rau txhaum kev puas siab puas ntsws psychomotor. Txawm li cas los xij, vim tias muaj kev pheej hmoo ntawm kev txhim kho cov kev tsis zoo uas tshwm sim tawm tsam keeb kwm yav dhau los ntawm kev txo ntshav siab lossis thaum kho kev kho, kev ceeb toom yog qhia thaum tsav tsheb thiab cov txheej txheem nyuaj, tshwj xeeb tshaj yog thaum pib kho.

Cev xeeb tub thiab lactation

Kev siv ntawm Noliprel A Forte yog sib txawv thaum lub caij xeeb tub thiab pub niam mis.

Thaum npaj lub cev xeeb tub los yog muaj teeb meem thaum lub sij hawm kho, cov tshuaj yuav tsum tau txiav thiab lub hypotensive tus neeg sawv cev pom zoo rau kev siv thaum cev xeeb tub yuav tsum tau kho.

Kev siv cov tshuaj ACE inhibitors nyob rau hauv II - III txiav tawm hauv plab cev xeeb tub tuaj yeem ua rau muaj kev cuam tshuam loj heev ntawm tus menyuam hauv plab (txo lub raum kev ua haujlwm, ncua sijhawm ossification ntawm cov pob txha pob txha taub hau, oligohydramnios) thiab kev txhim kho ntawm cov teeb meem hauv cov menyuam yug tshiab (lub raum tsis ua haujlwm, mob ntshav qis thiab / lossis hyperkalemia).

Tsis tas li ntawd, kev kho mob mus ntev nrog thiazide diuretics hauv III lub sijhawm cev xeeb tub tsis zoo cuam tshuam rau lub cev ntawm ntshav utero-placental, thiab ua rau hypovolemia hauv niam.

Nrog lub raum tsis ua haujlwm

Kev siv ntawm Noliprel A Forte yog contraindicated rau kev mob tsis zoo rau lub raum (CC tsawg dua 30 ml / min).

Hauv lub raum tsis ua haujlwm rau cov neeg mob nrog CC 30-60 ml / min, kev teem caij ua ke ntawm cov tshuaj yuav tsum tau ua tom qab kev kho mob monotherapy nrog txhua yam ntawm cov nquag siv. Nws yog qhov tsim nyog los siv koob tshuaj uas tso cai rau ua kom tau zoo tshaj plaws hauv kev kho mob.

Hauv lub raum tsis ua haujlwm nrog CC ntawm 60 ml / min thiab saum toj no, cov koob tshuaj li niaj zaus ntawm Noliprel A forte yog tus kws kho, nrog kev kho mob nrog kev soj ntsuam ib txwm muaj ntshav creatinine thiab potassium ntau ntau.

Yeeb tshuaj sib cuam tshuam

lithium kev npaj: kev sib xyaw ntawm ACE inhibitor thiab lithium kev npaj tau nce qhov kev pheej hmoo ntawm kev thim rov qab nce ntxiv nyob rau hauv cov concentration ntawm lithium hauv cov ntshav plasma thiab kev txhim kho ntawm cov tshuaj lom. Lub xub ntiag ntawm thiazide diuretics tsuas yog ua rau cov kab mob tshwm sim sai sai. Kev pom zoo siv nrog kev kho mob nrog lithium tsis pom zoo. Yog tias nws yuav tsum tau ua kev kho ua ke, kev saib xyuas tsis tu ncua ntawm cov ntsiab lus lithium hauv cov ntshav ntshav yuav tsum,
baclofen: ua kom cov nyhuv hypotensive. Txog kev kho cov tshuaj raws sijhawm, lub raum ua haujlwm thiab ntshav siab yuav tsum tau saib xyuas.
non-steroidal anti-inflammatory drugs (NSAIDs) (suav nrog txhua hnub ntawm acetylsalicylic acid siab dua 3 g): cyclooxygenase-2 inhibitors (COX-2), tsis siv tshuaj NSAIDs thiab tshuaj tiv thaiv ntawm acetylsalicylic acid txo cov nyhuv antihypertensive ntawm perindopril thiab ua rau muaj kev pheej hmoo ntawm mob raum tsis ua hauj lwm thiab nce nce cov ntshiab poov tshuaj ntsiab lus (tshwj xeeb yog pib ua rau lub raum tsis zoo)
tricyclic antidepressants, antipsychotics (antipsychotics): nrog rau kev siv Noliprel A forte tib lub sijhawm, lawv txhim kho cov nyhuv hypotensive, ua rau muaj kev pheej hmoo ntawm orthostatic hypotension,
corticosteroids, tetracosactide: ua rau muaj qhov txo qis hauv cov nyhuv antihypertensive. Kev txiav txim ntawm corticosteroids txhawb kev tuav cov kua dej thiab sodium ions,
lwm cov tshuaj tiv thaiv kev tiv thaiv thiab vasodilators: tuaj yeem txhim kho cov nyhuv hypotensive ntawm cov tshuaj. Nitroglycerin, nitrates thiab vasodilators tuaj yeem txo qis ntshav siab,
potassium-sparing diuretics (suav nrog amiloride, spironolactone, eplerenone, triamteren), kev npaj poov tshuaj, cov tshuaj potassium ntxiv rau cov tshuaj noj ntsev: cov neeg sawv cev no tuaj yeem ua rau muaj kev nce siab ntxiv hauv cov qib potassium ntxiv hauv cov ntshav, nrog rau cov ua kom neeg tuag taus. Hauv qhov no, nrog kev paub tseeb hypokalemia, lawv kev sib xyaw nrog cov tshuaj yuav tsum tau nrog los ntawm kev soj ntsuam cov poov tshuaj nyob hauv cov ntshav ntshav thiab ECG qhov tsis txaus,
estramustine: qhov kev pheej hmoo ntawm kev mob tshwm sim thiab qhov xwm txheej tsis zoo yog nce
insulin thiab sulfonylurea derivatives (cov tshuaj tiv thaiv kab mob ntshav qab zib): hauv cov neeg mob ntshav qab zib, cov nyhuv tshuaj tiv thaiv ntshav qabzib ntawm insulin thiab sulfonylurea derivatives yuav ua kom zoo dua,
allopurinol, immunosuppressive thiab cytostatic agents, corticosteroids rau kev siv tshuaj, procainamide: ua ke nrog cov neeg sawv cev no tuaj yeem ua rau muaj kev pheej hmoo ntawm kev tsim leukopenia,
cov tshuaj loog rau kev noj tshuaj: kev siv cov tshuaj loog thoob plaws lub zog ua kom cov nyhuv antihypertensive,
thiazide thiab "voj" diuretics: tshuaj tiv thaiv ntau ntawm diuretics tuaj yeem ua rau hypovolemia thiab arterial hypotension,
linagliptin, sitagliptin, vildagliptin, saxagliptin (gliptins): ua rau muaj kev phom sij ntawm angioedema,
sympathomimetics: muaj peev xwm ua kom tsis muaj zog ntawm cov nyhuv antihypertensive,
kev npaj kub: tawm tsam keeb kwm ntawm iv kev tswj hwm kub, npaj cov tshuaj tiv thaiv nitrate yuav tshwm sim (ntsej muag tawv nqaij hyperemia, ntshav tawm ntshav ntawm lub ntsej muag, xeev siab, ntuav),
quinidine, disopyramide, hydroquinidine (cov tshuaj antiarrhythmic ntawm chav kawm IA), ibutilide, amiodarone, dofetilide, bretilia tosylate (tshuaj tiv thaiv ntawm cov chav kawm III), sotalol, chlorpromazine, ciamemazine, levomepromazine, thioridazine, trifluoperazine (thifidideide ,ine) neuro droperidol, haloperidol, pimozide, bepridil, diphenyl methyl sulfate, cisapride, erythromycin thiab vincamine (iv), misolastine, moxifloxacin, pentamidine, halofantrine, sparfloxacin, methadone, terfenadine, astemizole indapamide tuaj yeem pab txhawb kev txo cov poov tshuaj hauv cov ntshav ntshav thiab qhov tshwm sim ntawm pirouette hom arrhythmias. Yog tias nws yog qhov yuav tsum tau sau tawm cov nyiaj no, yuav tsum tau saib xyuas tshwj xeeb los tswj cov ntsiab lus hauv cov ntshav hauv ntshav thiab QT ntu,
amphotericin B (iv), mauj glucocorticoids thiab mineralocorticoids, tetracosactides thiab laxatives uas txhawb cov plab hnyuv: ua rau muaj kev phom sij ntawm hypokalemia,
mob ntshav glycosides: nws yuav tsum tau yug los rau hauv lub siab tias hypokalemia tuaj yeem txhim kho lub cev muaj txiaj ntsig ntawm kev mob plawv glycosides, yog li ntawd nws raug nquahu kom tswj cov ntsiab lus poov tshuaj hauv cov ntshav plasma thiab ECG cov kev txwv thiab ua rau kev kho kom tsim nyog ntawm kev kho,
metformin: qhov tseem ceeb ntawm kev ua haujlwm lub raum tsis ua haujlwm uas tau tshwm sim thaum noj tshuaj diuretic, uas thaum ua ke nrog metformin, ua rau muaj kev pheej hmoo ntawm cov kab mob lactic acidosis, yuav tsum raug txiav txim siab. Yog tias qhov concentration ntawm creatinine nyob rau hauv cov ntshav ntshav hauv cov txiv neej tshaj 15 mg / l, thiab hauv cov poj niam - 12 mg / l, metformin yuav tsum tsis txhob siv tshuaj,
iodine-cov muaj teeb meem tshuaj tiv thaiv: kev txhaj tshuaj ntau ntawm cov tshuaj iodine uas muaj cov tshuaj tiv thaiv tiv thaiv cov keeb kwm yav dhau ntawm lub cev qhuav dej (vim yog noj cov tshuaj diuretic) ntawm lub cev ua rau muaj kev pheej hmoo ntawm lub raum tsis ua haujlwm, uas yuav tsum tau them nyiaj rau cov kua dej ua ntej siv cov tshuaj tiv thaiv iodine uas muaj cov tshuaj tiv thaiv tsis zoo.
poov ntsev ntsev: kev txo qis hauv kev nthuav tawm ntawm cov calcium ions los ntawm ob lub raum yog ua tau, uas ua rau muaj kev pheej hmoo ntawm hypercalcemia,
cyclosporine: kev ua xyem xyav ntawm cyclosporine hauv ntshav plasma tsis hloov, tab sis nws muaj peev xwm nce creatinine hauv ntshav ntshav, suav nrog cov ntsiab lus ib txwm ntawm dej thiab sodium ions.

Cov qauv ntawm Noliprel A forte yog: Noliprel, Noliprel A Bi-forte, Perindopril PLUS Indapamide, Co-Parnavel, Indapamide / Perindopril-Teva, Co-Perineva, Co-Preness, Perindapam, Perindide, Perindopril-Indapamide Richter.

Kev piav qhia ntawm cov tshuaj

Cov tshuaj ntawm cov ntsiav tshuaj muaj xws li Perindopril thiab Indapamide. Ob qho tshuaj muaj lub suab tawm tsam lub suab, tab sis qis dua tus tonometer hauv ntau txoj kev.

Perindopril yog ACE inhibitor, thiab Indapamide yog nyob rau chav kawm ntawm sulfonamide diuretics. Hauv kev sib koom ua ke, cov khoom siv no ua kom ib leeg pab tau.

Qhia tshuaj rau kom tsis txhob mob siab. Feem ntau, kws kho mob suav nrog Noliprel hauv kev kho kev mob ntshav siab.

Qhov siab tshaj plaws hypotensive kev tsim tawm tom qab ib hlis ntawm kev tswj hwm thiab mob siab rau lub sijhawm ntev. Cov tshuaj no siv tau txawm hais tias thaum lwm cov tshuaj tiv thaiv kab mob tsis pab.

Tib lub sijhawm, qhov nqi ntawm cov ntsiav tshuaj yog tus nqi tsawg. Coob leej ntau tus neeg yuav Noliprel, tab sis lawv tsis paub yuav ua li cas. Vim tias qhov no, kev tsis txaus siab feem ntau tshwm sim hais tias cov khoom tsis ua haujlwm lossis txo lub tonometer ntau dhau.

Kev txheeb xyuas ntawm Noliprel A Fort

Kev txheeb xyuas txog Noliprel A Fort yog qhov zoo. Cov neeg mob uas tau paub txog kev kho cov mob ntshav siab tshaj qhia tias hloov mus rau noj Noliprel A forte pub rau lawv ua kom ntshav nce siab li qub, thiab kev noj haus tsis tu ncua kom muaj kev ruaj khov. Qhia txog qhov tshwm sim ntawm cov tshuaj, cov neeg siv tau qhia kom tsis txhob pib noj tshuaj yam tsis muaj kev sab laj nrog kws kho mob.

Muab cov Noliprel

Noliprel tso tawm hauv ntau yam ntaub ntawv. Nws yog qhov tsim nyog rau cov neeg mob thiab cov kws kho mob kom nkag siab txog qhov tau ua tiav.

Noliprel A Bi-Forte

Cov tshuaj sib xyaw hauv qab no muaj ntau qhov txawv:

Noliprel (muaj 2 mg perindopril thiab 0.625 mg diuretic),
Noliprel Forte (kev noj tshuaj ntawm indapamide yog 1.25 mg, thiab perindopril yog 4 mg),
Noliprel A Forte (indapamide - 1,25 mg, perindopril - 5 mg),
Noliprel A Bi-Forte (perindopril muaj nyob hauv ib koob li 10 mg, thiab ib lub tshuaj diuretic - 2.5 mg),
Noliprel A (2.5 mg perindopril thiab 0.625 mg indapamide).

Noliprel A Bi-Forte yog cov muaj kev kho mob feem ntau thaum pom qhov siab ntau npaum. Yog tias muaj ntau cov koob tshuaj no, tus kws kho mob xaiv cov ntsiav tshuaj nrog cov ntsiab lus qis dua ntawm perindopril thiab indapamide.

Cov tshuaj Noliprel A, A Bi-Forte thiab A Forte muaj cov amino acid arginine, uas muaj cov txiaj ntsig zoo ntawm cov hlab plawv.

Yog li, yog tias muaj teeb meem plawv, nws tsim nyog siv cov tshuaj saum toj no. Rau txhua tus neeg mob, txoj kev xaiv tau xaiv ib tus zuj zus, noj mus rau hauv tus account concomitant pathologies, hnub nyoog. Cov neeg mob ntshav siab ntawm lub hnub nyoog siab tau pom zoo kom pib kho nrog ib ntsiav tshuaj.

Yuav ua li cas haus cov ntsiav tshuaj noliprel?

Cov tshuaj sib xyaw ua ke tau noj ib hnub ib zaug. Nws yooj yim heev, tshwj xeeb tshaj yog rau cov tibneeg hu tauj coob thiab cuam tshuam cov neeg.

Yog tias tus kws kho mob tau sau Noliprel, yuav ua li cas noj cov tshuaj no ua ntej lossis tom qab noj mov yog qhov teebmeem kub rau ntau tus neeg mob.

Nom tswv tsis muab lus teb. Nws tsuas yog qhia tias yuav tsum tau haus tshuaj thaum sawv ntxov.

Cov kws kho mob pom zoo kom siv cov tshuaj ua ntej noj tshais. Nws raug nquahu kom noj cov ntsiav tshuaj tib lub sijhawm. Tom qab ntawd cov nyhuv ntawm kev kho mob yuav hais tawm ntau yam thiab tsis muaj kev phiv tshuaj.

Raws li rau qhov koob tshuaj, tus kws kho mob xub muab ib ntsiav tshuaj ib hnub. Tab sis, yog tias ib hlis tom qab pib kev kho mob qhov xav tau tsis xav tau, Noliprel Forte tau txais kev noj tshuaj nrog 4 mg perindopril thiab 1.25 indapamide. Qee zaum cov kws kho mob sau ntawv rau lwm cov tshuaj. Piv txwv, calcium antagonists raug ntxiv. Hauv qhov no, ntau npaum li cas ntawm tus neeg sawv cev antihypertensive yog txo qis me ntsis.

Yog tias qhov koob tau siab dhau lawm, cov tsos mob hauv qab no yog cai:

xeev siab thiab ntuav
tsaug zog
apathy
kiv taub hau
tsis muaj zog
bradycardia
cramps
tsaus muag
hws no
muaj ntshav siab ntxiv rau,
tsis tu ncua zis lossis tso zis heev.

Yog tias cov paib tshwm sim no, koj yuav tsum hu rau lub tsheb thauj neeg mob tam sim ntawd. Thiab thaum koj xis nyob me ntsis, koj yuav tsum teem caij nrog koj tus kws kho mob txhawm rau kho qhov ntau npaum li cas.

Txais tos thaum cev xeeb tub

Thaum lub caij cev xeeb tub, kev yug tus me nyuam tsis pom zoo kom noj Noliprel.

Yog tias ib tus poj niam tau siv yav dhau los siv cov tshuaj xws li, yuav tsum tau ua tiav thiab sab laj nrog kws kho mob kom muab tshuaj rau lwm tus.

Cov kev tshawb fawb txog cov teebmeem ntawm ACE inhibitors rau cov poj niam cev xeeb tub tsis tau ua. Nws tseem tsis tau paub meej meej tias cov tshuaj ua rau kev txhim kho ntawm tus menyuam hauv plab.

Yog li ntawd, yuav tsum tau saib xyuas kom zoo. Tom qab tag nrho, muaj kev pheej hmoo tias cov tshuaj yeeb dej caw ntawm lub tshuaj tuaj yeem cuam tshuam loj heev rau kev tsim cov pob txha pob txha, kev ua haujlwm ntawm lub raum ntawm cov menyuam mos. Tsis tas li ntawd yuav ua rau muaj kev pheej hmoo ntawm cov hlab ntsha hypotension.

Cov tshuaj no tseem sib kis hauv kev pub niam mis, vim nws inhibits lactation thiab txo qhov ntau ntawm cov kua mis hauv leej niam. Tawm tsam keeb kwm yav dhau los ntawm kev noj cov tshuaj xws li, tus menyuam yaus tuaj yeem muaj hypokalemia, daj ntseg.

Lub sijhawm kho

Noliprel feem ntau yog cov tshuaj tseem ceeb siv los kho ntshav siab.

Ntsiav tshuaj yog tso cai rau siv sijhawm ntev, tab sis nws yog qhov tsim nyog kom siv sijhawm luv. Txwv tsis pub, cov tshuaj yuav cuam tshuam loj heev rau kev ua haujlwm ntawm lub raum thiab mob siab.

Ntev npaum li cas los haus Noliprel, koob tshuaj - txhua yam no yuav tsum tau txiav txim siab los ntawm tus kws kho mob, muab cov xwm txheej ntawm tus neeg mob.

Cov tshuaj yog contraindicated rau hauv cov neeg mob uas mob raum tsis ua haujlwm. Nrog mob raum tsis ua haujlwm, qhov muab yuav tsum tsis pub ntau tshaj ib ntsiav tshuaj ib hnub.

Hauv qee tus neeg mob uas lub raum tsis zoo ua haujlwm thaum noj tshuaj, kuaj pom tias tsis muaj txaus ntawm cov khoom nruab nrog cev no tshwm sim. Hauv qhov no, qhov kho tau nres. Nyob rau hauv lub neej yav tom ntej, nws raug tso cai rau kev rov ua haujlwm ntxiv, tab sis ntawm kev siv tshuaj ntau kawg thiab chav kawm luv.

Kev kho mob ntev nrog Noliprel tsis pom zoo rau cov kab mob zoo li no:

angina pectoris ,,,
scleroderma,
hyperuricemia
mob ntshav qab zib mellitus
mauj lupus erythematosus,
hypertrophic cardiomyopathy,
aortic valve stenosis,
lub plawv tsis ua hauj lwm

Cov tshuaj yeeb yaj kiab pab tswj kom ua siab nyob rau theem ntawm 130-140 / 80-90 hli. Hg. Kos duab. thiab hauv qab.

Yog li, txoj kev pheej hmoo ntawm mob hlab ntsha tawg, plawv nres thiab lub raum tsis ua haujlwm yog txo qis. Qhov ua tau zoo ntawm cov tshuaj tau lees paub los ntawm cov kws kho mob.

Cov kws kho mob nco ntsoov tias cov cuab yeej sai tso cai rau koj kho lub tonometer thiab feem ntau tsis ua rau muaj kev mob tshwm sim. Feem ntau cov teeb meem tshwm sim hauv cov neeg mob ntshav siab thaum noj Noliprel cuam tshuam txog qhov tseeb tias cov neeg mob tsis noj cov ntsiav tshuaj kom raug, tsis ua raws li cov lus pom zoo ntawm tus kws kho mob tuaj koom.

Cov neeg mob siab siab nco ntsoov tias Noliprel muaj nqis, nws tuaj yeem yuav tom lub tsev muag tshuaj twg. Tab sis qee zaum cov tshuaj tsis tuaj muag. Hauv qhov no, analogues raug tso cai. Piv txwv, Co-perineva, Prestarium, Perindopril thiab Indapamide Forte, Co-prenes, Quinard, Mipril, Lysopres, Capotiazide, Iruzid. Kuj tsim nyog hloov yog Ena sandoz, uas yog tsim nyog rau kev kho mob ntawm qhov tseem ceeb ntshav siab, mob plawv tsis xwm yeem, nrog rau kev tiv thaiv ntawm myocardial infarction.

Noliprel Forte: muaj pes tsawg leeg thiab daim ntawv ntawm kev tso tawm

Txhawm rau kom lub siab ceev, siv yeeb siv tshuaj ntawm ntau yam teebmeem tau siv. Yeej, cov no yog cov tshuaj diuretics - tshuaj tso tawm uas tshem tawm cov kua dej ntau dhau thiab cov dej qab ntsev hauv cov ntshav, txo nws cov nyiaj thiab txhim kho cov ntshav txaus. Lawv tseem ua ke nrog cov tshuaj uas qhov kev ua yog tsom rau txwv tsis pub cov kev ua haujlwm ntawm cov enzyme uas hloov angiotensin I mus rau angiotensin II.

Nrog kev poob qis hauv lub raum ntshav, prorenin yog tsim, uas, thaum nws nkag mus rau hauv cov ntshav ntshav, hloov mus rau hauv renin, khi rau angiotensinogen, tsim cov tshuaj angiotensin I. Cov compound no ua haujlwm los ntawm angiotensin II hauv kev ua haujlwm ntawm cov ntshav enzymes. Nyob rau tib lub sijhawm, cov hlab ntsha tau nqaim, lub plawv hloov qis, lub siab lub plawv ntawm cov hlab ntsha hauv lub luag haujlwm, uas yog lub luag haujlwm ntawm lub siab, dhau los ua tus pog, aldosterone yog tsim, uas khaws cov ntsev thiab dej, dua ntxiv kev thauj mus rau hauv lub cev. Tus txheej txheem no yuam koj coj tshuaj antihypertensive dua thiab rov ua dua.

Noliprel A Forte (Noliprel Forte) - cov cuab yeej niaj hnub ntawm kev sib koom ua ke: diuretic thiab inhibitory kev ua si ntawm angiotensin-hloov enzyme. Ua kom cov txiaj ntsig ntawm txoj kev kho, txo cov kev mob tshwm sim thiab cov teeb meem.

Cov tshuaj no tseem muaj nyob rau hauv txo qis ntawm cov khoom ua ub no hu ua Noliprel A. Nws yog qhia rau cov neeg mob uas nws tsis tuaj yeem ua rau kev kho mob nrog kev ua kom zoo dua qub.

Cov tshuaj muaj ob qho kev nquag:

indapamide (1.25 mg),
perindopril arginine (5 mg).

sodium carboxymethyl hmoov txhuv nplej siab (2.7 mg),
silica (0.27 mg),
lactose li monohydrate (71.33 mg),
magnesium stearate (0.45 mg),
maltodextrin (9 mg).

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm convex oval dawb ntsiav tshuaj. Ntim rau hauv lub hwj yas nrog lub dispenser thiab lub hau noo-ntawv pov thawj ntawm 14 lossis 30 pcs.

Tshuaj ntsuab kev txiav txim

Indapamide thiab Perindopril yog cov tshuaj tiv thaiv kab mob ntawm cov pab pawg sib txawv, tab sis ua ke ua ke hauv kev kho nyuaj. Cov tshuaj muaj zog synergistic, txhim kho ib leeg qhov kev ua, pab txo kev noj tshuaj thiab txo kev phiv.

Cov neeg siv rau sulfonamides, yog ib cov tshuaj diuretic. Los ntawm inhibiting qhov kev nqus ntawm sodium ions hauv cov ntshav, nws sai sai tshem lawv rau ob lub raum nrog rau cov ntshav ntau dhau, nce mus tso zis. Xws li qhov kev ua no muaj peev xwm txo qis qhov ceev ntawm cov kua dej hauv cov hlab ntsha, txhim kho cov ntshav ntws, ua kom lub plawv dhia.

Indapamide txo qis kev raug mob ntawm cov vascular phab ntsa mus rau kev ua ntawm angiotensin II. Tsis tas li ntawd, cov tshuaj txo cov concentration ntawm cov calcium nyob rau hauv cov ntshav vim nws cov zis hauv cov zis, uas yog txo qhov% ntawm nws lub tebchaw nkag mus rau cov nqaij mos myocardial.

Cov calcium ua rau cov leeg ua haujlwm sib zog, uas ua rau lub plawv dhia thiab nce siab.

Indapamide txo cov cim tsim ntawm oxygen dawb radicals, uas ua rau lub cev laus thiab cov tsos mob ntawm neoplasms.

Cov tshuaj no nrawm nrawm los ntawm khi rau ntshav protein, nqaij elastin. Nws yog tawm tsuas yog los ntawm lub raum. Txog 30% tau tshem tawm lub siab nyob rau hauv daim ntawv ntawm metabolites lossis tus mob thaum pib.

Indapamide muaj cov koob tshuaj uas siv tshuaj ntau, yog li ntawd, nws tau raug xaj rau lub chav kho mob.

Perindopril

Ib feem uas tiv thaiv qhov pom ntawm angiotensin II - muaj zog vasoconstrictor. Nws kuj tseem muaj lwm cov teebmeem uas cuam tshuam zoo rau kev saib xyuas cov ntshav ntsuas kom ruaj khov:

txo aldosterone ntau lawm,
nce renin kev ua si,
txo lub plawv dhia yam tsis pauv lawv cov lus sib dhos.

Perindopril txhim kho cov ntshav txaus, txo cov kev thauj mus los ntawm lub plawv mob, txo kev pheej hmoo ntawm lub plawv nres, tiv thaiv kev txhim kho hyperplasia lossis hypertrophy ntawm cov leeg nqaij ntawm lub plawv, ua kom dhau cardio- thiab cov nyhuv angioprotective.

Txo cov ntshav siab, cov tshuaj yog noj ib zaug - qhov tshwm sim tshwm sim tom qab 4 teev thiab kav rau ib hnub - thiab chav kawm. Nrog rau kev siv txhua hnub, cov lus tshaj tawm zoo tshaj plaws pom tau tias tom qab ib hlis thiab tawm mus ntev.

Daim ntawv thov rau lub sijhawm 6 lub hlis lossis ntau dua ua rau txo txoj kev hnyav ntawm lub plawv thiab cov hlab ntsha thiab nce lub siab rau lub cev hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev. Perindopril tsis yog ib hom muaj yees.

Thaum noj, nws nrawm nrawm, tsis muaj zog khi rau cov ntshav protein, metabolized los ntawm daim siab, tawm los ntawm lub raum thiab cov quav.

Cov tshuaj yog tawm rau kev kho mob ntawm qhov tseem ceeb tawg - ib qho kev tiv thaiv ib puag ncig (3-4 zaug hauv ib hnub) siab nce siab tshaj 140/90. Feem ntau kuaj mob rau cov neeg mob hnub nyoog 35-40 xyoo thiab tsis muaj laj thawj dab tsi.

Kev tswj hwm cov chav haujlwm tsis tu ncua ntawm cov tshuaj "Noliprel Forte" nyob rau thaum ntxov ntawm tus kab mob tuaj yeem ua tiav qhov siab ceev. Hauv qhov mob hnyav, theem peb, thaum ntshav nce siab mus txog 180/110, nws tswj tau qis, ua kom tsis muaj teeb meem ntshav thiab plawv nres.

Cov tshuaj yog qhia rau kev siv hauv cov neeg mob nrog rau kev sib luag rau cov mob ntshav siab thiab hom 2 mob ntshav qab zib mellitus, raws li txhais tau tias muaj kev tiv thaiv ntawm cov kev mob sib kis.

Noliprel Forte Ntsiav Tshuaj

Cov tshuaj no muaj txiaj ntsig zoo tiv thaiv kev kub siab. Vim tias cov tshuaj sib txawv tshwj xeeb, kev ua tiav zoo ntawm cov khoom tseem ceeb (perindopril, indapamide), Noliprel ceev cov ntshav khov thiab tshem tawm cov kua dej hauv lub cev. Qhov ua kom zoo nyob ntev ntawm Noliprel tshwm sim tom qab 3-4 lub lis piam los ntawm kev pib kho thiab tsis nrog tachycardia. Cov tshuaj yog raug kho rau kev kho mob hauv tsev, nrog kev saib xyuas ib ntus los ntawm tus kws kho mob txhawm rau kho cov tshuaj.

Muaj pes tsawg leeg ntawm Noliprel

Cov tshuaj muaj nyob hauv oblong dawb cov ntsiav tshuaj. Noliprel muaj ntau hom uas muaj cov tshuaj sib txawv ntawm cov khoom tseem ceeb: perindopril, indapamide. Cov tshuaj sib xyaw tag nrho ntawm cov tshuaj tau nthuav tawm hauv lub rooj:

Perindopril concentration, hauv mg

Qhov concentration ntawm indapamide, hauv mg

lactose monohydrate, microcrystalline cellulose, hydrophobic colloidal silicon, arginine (suav nrog hauv daim ntawv tso tawm nrog tus lej ua ntej "A")

Noliprel A Bi-Forte

Noliprel Ib Forte

Pharmacological kev txiav txim

Cov tshuaj Noliprel yog kev sib txuas ntawm ob yam tshuaj loj uas muaj lawv tus kheej tshwj xeeb thiab muaj ntau yam teebmeem:

Perindopril. Txo cov ntshav siab rau qib ib txwm, txo kev tsis kam nyob rau hauv cov hlab ntshav, ua kom cov phab ntsa ntawm cov hlab ntsha ua kom siab dua, ua kom lub plawv ruaj khov, txo cov leeg ventricular hypertrophy, ua rau txo lub nra tawm ntawm lub plawv mob.
Indapamide. Nws tshem tawm cov kua ntau dhau los ntawm lub raum, muaj cov diuretic thiab vasoconstrictor effect.

Kev ntsuas rau siv

Ntsiav tshuaj rau lub siab Noliprel tsuas yog siv rau qhov ntsuas kev kho mob - qhov tseem ceeb (thawj) hlab ntaws ntshav. Tus kabmob no tshwm sim los ntawm cov kabmob ntawm cov thyroid caj pas, lub raum. Txawm li cas los xij, raws li cov lus qhia, cov tshuaj tuaj yeem raug kho rau lub hom phiaj prophylactic rau kev kho mob vascular pathologies hauv cov neeg mob ntawm cov pab pawg tshwj xeeb (mob ntshav siab, hom II mob ntshav qab zib mellitus).

Kev Taw Qhia Noliprel Forte

Qhov zoo ntawm lub tshuaj yog tias nws yuav tsum tau noj ib hnub ib zaug. Qhov no yooj yim rau cov neeg laus, uas feem ntau txom nyem los ntawm tsis nco qab lawm. Lub sijhawm zoo rau noj tshuaj thaum sawv ntxov. 1 lub tshuaj yuav tsum tau nqos (tsis txhob zom, tsis txhob faib ua ob zaug) ua ntej noj mov, haus dej kom ntau. Cov kev ua ntawm cov ntsiav tshuaj tau manifested 2-5 teev tom qab siv thiab kav rau 24 teev. Tom qab ib hlis thiab ib nrab ntawm kev noj cov tshuaj, tus kws kho mob kho cov tshuaj ntau npaum li cas.

Thaum cev xeeb tub

Kev siv cov tshuaj Noliprel tiv thaiv kev kub nyhiab yog txwv nruj thaum lub sij hawm yug menyuam thiab pub niam mis. Thaum npaj lossis cev xeeb tub, kev siv tshuaj tiv thaiv kabmob kub yuav tsum nres tam sim ntawd. Cov tshuaj ua haujlwm ntawm Noliprel tuaj yeem cuam tshuam tsis zoo rau kev loj hlob ntawm tus me nyuam hauv plab, ua rau:

lub raum tsis ua hauj lwm
amniotic kua ntim txo qis,
lub raum tsis ua haujlwm nyob hauv tus menyuam,
qeeb hauv me nyuam hauv plab txoj kev loj hlob cuam tshuam nrog fetotoxicity,
qeeb tsim ntawm pob txha ntawm pob txha taub hau ntawm cov menyuam,
leeg ntshav siab.

Thaum pub niam mis, Noliprel yuav tsum tsis ua mus ntxiv. Cov tshuaj ntawm cov tshuaj txo cov mis ntau thiab txo cov lactation. Ib qho ntxiv, Noliprel tuaj yeem cuam tshuam tsis zoo rau tus menyuam lub cev, ua rau mob tawv nqaij lossis mob ntshav lub cev. Yog tias cov tshuaj tseem ceeb rau kev noj qab haus huv ntawm leej niam thiab tsis muaj ib yam dab tsi los hloov nws, tus menyuam yuav tsum tau hloov mus ib ntus rau khoom noj khoom haus.

Hauv thaum yau

Noliprel tsis pom zoo rau kev kho mob menyuam yaus thiab tub ntxhais hluas uas muaj hnub nyoog qis dua 18 xyoo. Qhov tshwm sim, kev mob tshwm sim thiab tshwm sim ntawm cov tshuaj rau cov me nyuam lub cev tsis tau tsim. Kev tsis quav ntsej cov lus sib cuam tshuam no tuaj yeem ua rau tus neeg mob lub cev noj qab haus huv thiab chaw pw hauv tsev kho mob sai los kho tus neeg mob cov cim tseem ceeb.

Cov nqe lus ntawm kev muag khoom thiab kev cia khoom

Cov tshuaj raug muag los ntawm daim ntawv sau xaj. Tsis muaj kev tshwj xeeb cia, koj yuav tsum ua kom Noliprel ncav tsis cuag cov menyuam ntawm qhov kub uas tsis siab tshaj 30 degrees. Txee lub neej ntawm cov tshuaj tsis ntau tshaj 3 xyoos.

Muab tus nqi siab ntawm Nolirel thiab ib daim ntawv teev ntau tshaj plaws ntawm contraindications, kev kho tuaj yeem hloov nrog lwm cov tsiaj ntxiv. Kev txiav txim siab los xaiv ib qho cuab yeej tshwj xeeb rau txo ntshav siab yuav tsum yog tus kws kho mob txiav txim. Kev ua tiav ntawm cov tshuaj indapamide thiab perindopril siv rau hauv cov tshuaj no:

Ko-Perineva,
Perindopril-Indapamide Richter,
Perindapam,
Co Parnawel
Perindid
Noliprel A
Indapamide Perindopril-Teva,
Egyptipres
Iruzid,
Txoj kab nruab nrab
Dalneva.

Cov lus qhia rau kev siv tshuaj

Lawm, qhov tshuaj hauv qhov no yuav tsum yog tus kheej, vim nws nyob ntawm lub hnub nyoog thiab cov neeg mob, nrog rau cov kab mob kuaj tau hauv nws. Txawm li cas los xij, muaj cov koob tshuaj pom zoo dav dav thiab cov cai muaj txiaj ntsig. Noliprel ntsiav tshuaj tau noj zoo tshaj plaws thaum sawv ntxov - txoj kev no cov nyhuv yuav tshwm sim sai dua thiab yuav kav ntev dua, thiab cov lus muaj zog yuav tsis cuam tshuam nrog txoj haujlwm li niaj zaus ntawm lub hnub.

Txog ntawm qhov ntau thiab tsawg, cov neeg laus tau hais qhia kom noj ib ntsiav tshuaj ib hnub. Yog tias tsim nyog, tus kws kho mob, tau kawg, tuaj yeem hloov qhov koob tshuaj lossis cov tshuaj noj tshiab.

Cov tshuaj "Noliprel forte": contraindications

Tsis tas li ntawd, kev mob siab rau daim siab thiab ntshav qab zib tseem ua haujlwm rau contraindications. Cov neeg mob uas muaj mob raum tsis raug txwv kuj tau txwv. Thiab, qhov tseeb, cov tshuaj tsis raug pom zoo rau cov menyuam yaus hnub nyoog qis dua 18 xyoo. Thiab vim tias cov khoom lag luam muaj cov lactose monohydrate, nws tsis yog kws kho rau cov neeg mob los ntawm lactose deficiency thiab qee lwm yam kab mob cuam tshuam nrog kev cuam tshuam cov metabolism metabolism.

Yog vim li cas koj thiaj li yuav tsum tsis txhob hnov qab tias cov tshuaj no tsuas yog kho tau los ntawm tus kws kho mob tom qab tau txais tag nrho cov txiaj ntsig ntawm kev sim thiab kev tshawb nrhiav. Yog tias muaj cov tshuaj contraindications, qhov yuav tshwm ntawm kev kho tuaj yeem ua rau muaj kev phom sij rau kev noj qab haus huv thiab lub neej.

Muaj kev phiv tshuaj tiv thaiv

Qee zaum, kev noj tshuaj pab ua rau muaj kev ua txhaum ntawm lub ntsws ua pa - hnoos qhuav, bronchospasm, rhinorrhea yuav tshwm sim. Tsawg tsawg zaus, kev siv cov tshuaj tuaj yeem tuaj yeem ua rau angina pectoris, arrhythmias, mob stroke, plawv nres, mob raum tsis ua haujlwm.

Qee zaum muaj xeev siab, ntuav, tso quav tsis taus, qhov ncauj qhuav. Tsis tshua muaj, kev kho ua rau kev txhim kho kabmob lossis tawv nqaij jaundice.

Cov Ntaub Ntawv Ntxiv

Nws tsim nyog pom tias thawj koob tshuaj thawj zaug tuaj yeem ua rau mob ntshav siab - tsis tas yuav ntshai, qhov no yog qhov qub, tshwj xeeb tshaj yog thawj ob peb hnub. Tab sis xws li tus neeg mob yuav tsum nyob hauv qab kev saib xyuas ntawm cov neeg kho mob tas li.

Tsis tas li ntawd, nws yog ib qho tsim nyog yuav tsum tau ua qhov kev sim los ntawm ib lub sijhawm rau lub sijhawm kho - qhov no pab soj ntsuam theem ntawm creatinine thiab poov tshuaj nyob rau hauv cov ntshav, txij li kev hloov pauv los ntawm tus txheej txheem muaj peev xwm ua tau raws li cov tshuaj.

Cov kws kho mob kuj tsis pom zoo kom tsav tsheb thaum kho, ua haujlwm nrog ntau cov txheej txheem uas yuav tsum muaj kev xav ntau thiab muaj kev tawm tsam sai. Ua ntej pib kev kho mob, nco ntsoov qhia koj tus kws kho mob txog cov tshuaj uas koj noj, vim tias Noliprel Forte tshuaj sib xyaw nrog lwm cov tshuaj tuaj yeem tsim kev phom sij.

Kev Ntsuam Xyuas Neeg Siv Khoom

Ntawm qhov tod tes, cov tshuaj "Noliprel forte" muaj qee qhov tsis zoo. Yuav pib nrog, nws tsim nyog sau nws cov nqi - tus nqi no tsis haum rau txhua tus, tshwj xeeb tshaj yog thaum nws los txog kev kho mob ntev. Tsis tas li ntawd, qee cov neeg mob uas tau noj tshuaj ntev (2-3 lub hlis) tau tsim txoj kev mob tsis zoo dhau los - txiav plaub hau. Thaum muaj kev ua txhaum cai li no, koj yuav tsum sab laj nrog kws kho mob: koj xav tau Nevipres piv txwv (piv txwv li Enap N). Los ntawm txoj kev, koj tuaj yeem yuav cov khoom lag luam uas muaj cov khoom tseem ceeb ntawm cov tshuaj (perindopril thiab indapamide) - kev noj lawv yuav pab kom ua tiav cov txiaj ntsig ib yam, tab sis kev pheej hmoo ntawm kev plhaw mas yuav muaj tsawg dua.

Kev kho kiag

Nws raug nquahu kom noj cov tshuaj 1 ntsiav tshuaj thaum sawv ntxov ua ntej noj tshais. Ib koob tshuaj ntawm Noliprel Forte txaus los tswj qhov kev kho mob thawm hnub.

Cov neeg mob uas mob ntshav qab zib mellitus, mob raum lossis mob pob txha taub hau tsis muaj txiaj ntsig tau pom tias pib kho nrog tshuaj "Noliprel A".

Qhov ntau npaum li cas thiab cov lus pom zoo rau kev siv tshuaj yog muab los ntawm tus kws kho mob tuaj koom. Yog tias tag nrho cov lus qhia tau ua raws, qhov kev pheej hmoo ntawm qhov tshwm sim thiab qhov tshwm sim yog qhov tsawg heev, thiab qhov ua haujlwm ntawm kev kho yog qhov ntau.

Qee qhov xwm txheej, thaum nws tsis tuaj yeem xaiv qhov ntau npaum li cas, cov tshuaj hloov nrog monocomponent tshuaj thiab indapamide thiab perindopril tau kho nyob rau hauv tus neeg cov proportions.

Kev phiv tshuaj

Cov kev xav tsis zoo ntawm lub cev yuav tsum tsis txhob nrog cov txheej txheem kho. Yog tias qhov hloov pauv tus mob ua rau mob hnyav lossis cuam tshuam rau lub neej thiab kev noj qab haus huv, nco ntsoov qhia koj tus kws kho mob. Nws yuav hloov kho qhov tshuaj lossis hloov cov tshuaj.

Cov kev tsis txaus siab uas feem ntau ntawm cov neeg mob yog:

mob intracranial, kiv taub hau,
lwm qhov kev qhia ua xua - hyperemia, urticaria, khaus, tev,
cov tsos ntawm tinnitus, pom kev tsis sib xws,
qhov tshwm sim ntawm orthostatic hypotension yog qhov cuam tshuam,
nce dryness ntawm mucous daim nyias nyias ntawm lub qhov ncauj thiab lub qa, hnoos,
kev ua kom tsis muaj zog, mob leeg.

Cov teeb meem xws li pw tsis tsaug zog, arrhythmia, tachycardia, edema, qhov tsos ntawm kev tsis haum, kev tawm hws ntau yog tsawg dua.

Vim tias qhov hloov pauv hauv cov ntshav tsom, cov tshuaj yeeb yaj kiab tuaj yeem cuam tshuam rau kev ua haujlwm ntawm ib leeg. Yog li no, kev sim ua kom zoo sim ntsuas ntawm nws cov kev sib xyaw yog pom zoo.

Cov tshuaj "Noliprel Forte" muaj qhov tseeb pov thawj rau hauv kev kho mob ntawm kev mob ntshav siab.

Hauv cov neeg mob noj cov tshuaj, nws tau sau tseg:

cov kev kho mob tas mus li tom qab 2-3 lub lis piam tswj hwm,
txo qhov me me ntawm hypertrophied sab laug ventricle,
txhim kho ntawm kev mob thiab kev noj qab nyob zoo,
ua kom tiav qhov ntshav tsis txaus nyob hauv kev kho mob thaum pib ntawm kev kub siab.

Feem ntau, Noliprel zam tau yooj yim, thiab yog tias thev tsis nkag siab yog hloov los ntawm lwm cov tshuaj ntawm qhov kev ua zoo sib xws.

Koj tuaj yeem yuav cov tshuaj hauv lub tsev muag tshuaj. Nws raug tso tawm tsuas yog ntawm cov tshuaj noj. Kev txais tos yog tso cai tom qab sab laj nrog ib tus kws tshaj lij. Tus nqi nruab nrab ntawm cov tshuaj yog 680 rubles rau pob ntawm 30 pcs.