Awb M > Kev khomob thiab kev tiv thaiv

Ib qho tshuaj tiv thaiv ntawm cov tshuaj yog glimepiridemuaj peev xwm tsim kho kev zais cia thiab tso tawm tshuaj insulin los ntawm beta hlwb ntawm cov txiav, txhim kho qhov rhiab ntawm peripheral cov ntaub so ntswg mus rau tus ntawm endogenous insulin.

Lwm cov khoom siv ua kom nquag plias yog metformin yog cov tshuaj hypoglycemic uas yog ib feem ntawm cov pab pawg biguanide. Hauv qhov no, qhov ua rau lub ntsej muag hypoglycemic yog pom thaum tswj hwm kev zais cia tshuaj insulintxawm tias ib qho me me. Metformin tsis muaj qhov cuam tshuam tshwj xeeb rau kev tua kab mob hlwb pancreatic, cov tshuaj insulin zais cia, thiab nws txoj kev tswj hwm hauv kev siv tshuaj tsis ua rau muaj kev loj hlob ntshav qog.

Nws ntseeg tau tias metformin muaj peev xwm ua kom muaj zog txog qhov ua tau zoo ntawm insulin, nce qhov rhiab ntawm cov ntaub so ntswg rau nws, inhibit gluconeogenesis nyob rau hauv daim siab, txo cov khoom noj ntawm cov roj ua kom dawb, txo cov roj oxidation, qab los noj mov, nqus ntawm carbohydrates hauv cov hnyuv thiab lwm yam.

Qhov siab tshaj plaws ntawm cov tshuaj hauv cov ntshav ntshav tau mus txog hauv 2.5 teev tom qab rov qab muab 4 mg rau ib hnub. Sab hauv lub cev, nws ua tiav ntawm kev tsis muaj sia nyob yog sau tseg. Noj mov tsis muaj ntau yam tshwm sim ntawm kev nqus, tsuas yog ua kom qeeb qeeb ntawm nws qhov ceev. Lub ntsiab ntawm Amaryl M metabolites yog raug tawm hauv cov raum, thiab qhov ntxiv los ntawm txoj hnyuv.

Nws tau pom tias cov tshuaj muaj peev xwm nkag mus rau hauv qhov chaw tiv thaiv hniav thiab tawm hauv cov kua mis.

Kev ntsuas rau siv

Qhov tseem ceeb qhia rau kev teem caij Amaryl M yog hom 2 mob ntshav qab zib mellitus nrog kev mob ntawm kev noj haus, ua si lub cev thiab txo lub cev nyhav, yog tias:

glycemic tswj tsis ua tiav nrog kev sib xyaw nrog kev noj haus, ua kom lub cev, yuag yuag thiab monotherapy nrog metformin lossis glimepiride,
kev sib txuas ua ke glimepiride thiab metformin hloov los ntawm kev noj ib qho tshuaj sib xyaw.

Cov Yuav Tsum Muaj

Nws tsis pom zoo kom noj cov tshuaj no nrog:

ntshav qab zib hom 1
mob ketoacidosismob ntshav qab zib coma thiab precoma, mob los yog mob ntev metabolic acidosis,
hypersensitivity rau cov tshuaj,
lub siab ua rau lub siab ua haujlwm tsis zoo,
raum tsis ua hauj lwm thiab lub raum khiav tsis zoo,
propensity los tsim lactic acidosis,
tej kev ntxhov siab
tsis tau muaj 18 xyoo
malabsorption ntawm cov zaub mov thiab tshuaj los ntawm cov hnyuv,
cawv ntev, mob qaug cawv qaug cawv,
lactase deficiency, galactose intolerance, qabzib-galactose malabsorption,
lactation, cev xeeb tub thiab yog li ntawd.

Sab sij huam

Noj Amaril M, tshwj xeeb tshaj yog nyob rau theem pib, tuaj yeem ua rau ntau yam tsis xav paub txog kev cuam tshuam cov kabmob tseem ceeb thiab cov kab ke.

Kev tsim kho cov ntshav qog ntshav yog feem ntau ntawm qhov xwm txheej thiab yog nrog los ntawm: mob taub haukev tshaib nqhis, xeev siab, ntuav, nkees, nkees, kev ntxhov siab vim pw tsaug zog, kev txhawj xeebkev ua nruj ua tsiv, txo qis thiab ceev faj, qeeb qeeb ntawm lub cev psychomotor, kev nyuaj siab, tsis meej pemkev hais lus tsis pom kev thiab lub zeem muag, tshee hnyo thiab yog li ntawd.

Hauv qhov no, kev tawm tsam ntawm kev mob ntshav khov ntau heev yuav zoo ib yam li kev ua txhaum ntawm cov ntshav ncig ntawm lub hlwb. Koj tuaj yeem tshem tawm qhov tsis xav pom cov tsos mob los ntawm kev tshem tawm cov tsos mob pom ntawm glycemia.

Cov lus qhia rau Amaryl M (Txuj ci thiab ntau npaum li cas)

Qhov ntau npaum ntawm cov tshuaj Amaryl M feem ntau yog txiav txim siab los ntawm cov ntsiab lus ntawm lub hom phiaj tsom ntawm cov piam thaj hauv tib neeg cov ntshav. Txhawm rau kom tau txais cov kev tswj hwm kev zom zaub mov tsim nyog, kev kho mob pib nrog kev noj qab haus huv qis.

Hauv kev kho mob, cov piam thaj hauv ntshav thiab zis yuav tsum txiav txim siab tas li. Kev soj ntsuam tas li ntawm glycosylated hemoglobin hauv cov ntshav kuj tseem tsim nyog.

Yog tias kev tswj hwm tsis raug cai ntawm cov tshuaj lossis hla cov koob tshuaj tom ntej, nws tsis raug pom zoo kom rov ntxiv nws nrog kev siv tshuaj ntau dua.

Hauv kev kho mob ntawm Amaryl M, kev tswj kev zom zaubmov thiab cov nqaij mos rhiab ua rau tshuaj insulinuas txo qhov xav tau glimepirideCov. Yog li, koj yuav tsum tau txo cov tshuaj kom tsis tu ncua lossis tsum tsis txhob noj cov tshuaj, uas yuav zam kev txhim kho kev mob ntshav qab zib.

Feem ntau, sau ntawv siv 1-2 zaug ib hnub noj tshuaj ib txhij nrog zaub mov.

Kev noj ntau tshaj plaws txhua hnubglimepiride yog - 8 mg, thiab metformin - 2000 mg. Qhov kev tsim nyog tshaj plaws rau ib zaug yog suav tias yog qhov txais tos, raws li cov lus qhia rau Amaril M - 2 mg + 500 mg, ntsig txog.

Feem ntau, kev kho nrog Amaryl M cuam tshuam nws siv ntev.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Amaryl ntsiav tshuaj tau npaj muaj:

1 ml glimepiride - liab dawb,
2 ml ntawm glimepiride - ntsuab,
3 mg glimepiride - lub teeb daj
4 mg ntawm glimepiride - ntsuab.

Hauv cov hlwv rau 15 ntsiav tshuaj, 2 lub hlwv ib pob.

Ntu cov ntsiab lus ntawm Amaril yog: polyvidone 25000, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate.

Noj ntau dhau

Nrog kev noj tshuaj ntau dhau ntawm Amaryl M, kev mob ntshav qab zib tsawg zuj zus tuaj, qee zaum ua rau xeev tsis xeev thiab qaug dab peg, li no lactic acidosis.

Hauv cov xwm txheej zoo li no, txoj kev kho yog raug kho raws qhov mob hnyav ntshav qogCov. Yog tias daim ntawv me me tau sau tseg tsis muaj qhov tsis nco qab, hloov pauv ntawm cov hlab hlwb, nws raug nquahu kom noj cov dextrose (piam thaj) sab hauv, thiab tom qab ntawd hloov kho qhov ntau ntawm cov tshuaj thiab zaub mov noj. Rau qee lub sijhawm, nws yuav tsum tau ua tib zoo saib xyuas tus neeg mob kom txog thaum muaj kev phom sij rau kev noj qab haus huv thiab lub neej raug tshem tawm tag nrho.

Cov kev mob ntshav qab zib tsawg, nrog los ntawm kev tsis nco qab, mob nriaj thiab lwm yam mob hlwb, yuav tsum tau mus pw hauv tsev kho mob sai. Kev kho ntxiv yog nqa hauv tsev kho mob, raws li cov tsos mob.

Txoj kev thov thiab qhov ntau npaum li cas ntawm Amaril

Qhov ntau npaum li cas ntawm Amaril yog txiav txim siab raws li kev pib ua ntej cov piam thaj hauv cov ntshav.

Thaum pib, cov tshuaj tau sau tseg rau hauv lub koob tshuaj kom tsawg kawg kom ua tiav qhov kev xav tau ntawm kev tswj metabolic.

Thaum lub sij hawm siv ntawm Amaril, tus neeg mob yuav tsum tau soj ntsuam kom tsis tu ncua qib ntawm cov piam thaj hauv cov ntshav, nrog rau glycosylated hemoglobin.

Amaryl ntsiav tshuaj noj tag nrho, ntxuav nrog ib nrab ntawm khob dej.

Kev muab tshuaj thawj zaug ntawm Amaril yog 1 mg rau ib hnub. Kev nce qib yuav tsum tau maj mam ua, nrog lub sijhawm luv ntawm 1-2 lub lis piam, hauv cov txheej txheem hauv qab no 1 mg-2 mg-3 mg-4 mg-6 mg-8 mg ib hnub.

Raws li txoj cai, nrog zoo-tswj ntshav qab zib mellitus, noj tshuaj zoo ntawm Amaril yog 1-4 mg. Kev siv tshuaj Amaril hauv ib koob li 6 mg lossis ntau dua ib hnub yog siv rau qee pawg neeg mob.

Qhov ntau zaus thiab lub sijhawm ntawm kev siv Amaril yog txiav txim siab los ntawm tus kheej mus kawm kws kho mob, suav txog hnub nyoog, qhov mob hnyav, tus neeg mob lub neej, thiab kev noj zaub mov zoo li cas.

Kev noj tshuaj txhua hnub ntawm Amaril yuav tsum noj nyob hauv ib koob, feem ntau ua ntej noj tshais lossis lwm pluas noj. Nws yog ib qho tseem ceeb kom tsis txhob noj mov tom qab noj cov ntsiav tshuaj.

Thaum lub sij hawm siv cov Amaril, kev hloov kho ntau ntau yuav tsum muaj vim kev txhim kho metabolic tswj tau. Amaril kev hloov kho koob kuj yuav tsum muaj rau:

Txoj kev ua neej hloov
Lub cev yuag
Qhov tshwm sim ntawm yam ua rau kev loj hlob ntawm hyperglycemia lossis hypoglycemia.

Raws li cov lus qhia, Amaryl tau coj mus ntev.

Glimepiride

Glimepiride yog qhov tshuaj hypoglycemic hauv qhov ncauj uas yog tiam thib peb sulfonylurea derivative. Cov tshuaj nquag muaj cov nyhuv ua rau lub cev ua haujlwm los ntawm kev ua kom muaj zog thiab tsim tawm cov insulin los ntawm β-hlwb ntawm lub cev, nrog rau cov txiaj ntsig ntxiv, txhim kho qhov rhiab ntawm cov leeg thiab cov rog (peripheral) cov ntaub so ntswg rau cov kev cuam tshuam ntawm endulinous insulin.

Cov neeg sawv cev ntawm sulfonylurea derivatives nce insulin ntau lawm los ntawm kev kaw adenosine triphosphate (ATP) -nyob rau hauv cov poov tshuaj raws txoj haujlwm hauv thaj chaw cytoplasmic membrane ntawm pancreatic pan-hlwb. Qhov no thaiv ntawm cov poov tshuaj channel ua rau lub depolarization ntawm β-hlwb, uas ua rau kom qhib cov calcium calcium thiab kev nce hauv calcium ntau ntxiv.

Cov tshuaj yeeb dej caw txuas nrog / txiav tawm nrog qhov hloov pauv loj los ntawm cov protein ntawm the-hlwb ntawm cov kua roj ntshav (cov roj molecular 65 kD / SURX), uas cuam tshuam nrog ATP-dependant potassium, tab sis tsis zoo li lwm yam sulfonylurea derivatives, qhov sib txuas yog nqa tawm ntawm lwm qhov chaw (protein nrog mol.weight 140 kD / SUR1). Qhov no ua kom muaj zog tso tawm insulin los ntawm exocytosis, tab sis cov tshuaj insulin uas ua hauv cov txheej txheem no tau qis dua qis dua li kev ua dhau los ntawm qhov ib txwm ua, ib txwm siv sulfonylurea derivatives (glibenclamide thiab lwm tus). Qhov tsawg tshaj plaws stimulating nyhuv ntawm glimepiride ntawm kev tsim cov tshuaj insulin kuj tseem txo cov kev pheej hmoo ntawm hypoglycemia.

Glimepiride ua kom pom tseeb mus rau ntau qib, thaum piv nrog tsoos sulfonylurea derivatives, cov teebmeem ntxiv, tshwj xeeb, txo qis hauv insulin tsis kam, antiatherogenic, antioxidant thiab antiplatelet zog.

Qhov kev tshem tawm cov piam thaj ntawm cov ntshav yog nqa tawm los ntawm cov leeg thiab adipose cov nqaij nrog kev koom nrog tshwj xeeb thauj cov protein (GLUT1 thiab GLUT4) hauv ib cheeb tsam hauv cov cell. Hauv cov muaj ntshav qab zib hom 2 mob ntshav qab zib, piam thaj ua rau cov nqaij mos no hais txog theem ntawm nws qhov kev siv ntawm tus nqi tsawg. Glimepiride muab ntau ntxiv rau hauv cov lej thiab cov haujlwm ntawm cov piam thaj transporter lwg me me (GLUT1 thiab GLUT4), uas ua rau cov piam thaj nce ntxiv los ntawm cov ntaub so ntswg peripheral. Cov tshuaj nquag ua rau muaj zog ua rau lub ntsej muag tsis txaus siab ntawm ATP-calcium uas tso rau hauv cov hlab plawv hauv lub hlwb tsis muaj zog. Tawm tsam keeb kwm ntawm kev kho mob nrog glimepiride, lub peev xwm ntawm ischemic myocardial preconditioning seem.

Cov tshuaj nquag ua rau cov phospholipase C nce ntxiv, yog li ua rau cov lipo- thiab glycogenesis tshwm sim los ntawm cov tshuaj, thiab kuj txwv tsis pub cov kua nplaum tawm ntawm daim siab los ntawm kev ua kom muaj ntau ntxiv ntawm fructose-2,6-bisphosphate, uas nyob rau hauv lem inhibits gluconeogenesis.

Glimepiride xaiv tau inhibits kev ua si cyclooxygenase thiab txo qhov kev hloov pauv ntawm arachidonic acid rau thromboxane A₂ua si lub luag haujlwm tseem ceeb hauv platelet aggregation. Lub cuab yeej pab txo qis lipid thiab txo qis lawv cov peroxidation, uas cuam tshuam nrog nws cov nyhuv anti-atherogenic. Raws li qhov tshwm sim ntawm cov tshuaj, cov tshuaj lom ntawm endogenous alpha-tocopherol nce ntxiv, nrog rau cov kev ua ntawm glutathione peroxidase, catalase thiab superoxide dismutase, uas txo cov kev mob oxidative hauv lub cev, uas ib txwm muaj nyob rau hauv hom 2 ntshav qab zib.

Metformin yog qhov tshuaj hypoglycemic uas yog ib feem ntawm pab pawg biguanide, cov nyhuv hypoglycemic uas tau pom tsuas tiv thaiv keeb kwm yav dhau los ntawm kev khaws cia ntawm insulin ntau lawm (txawm hais tias txo qis). Cov tshuaj yeeb dej caw tsis cuam tshuam rau β-hlwb ntawm tus txiav thiab tsis txhawb kev tsim tawm ntawm cov tshuaj insulin, yog li ntawd, hauv kev kho mob nws tsis ua rau kev txhim kho hypoglycemia hauv tib neeg.

Tus txheej txheem ntawm kev ua ntawm cov tshuaj tseem tsis tau raug teeb tsa tag nrho, txawm li cas los xij, ntseeg tau tias metformin muaj peev xwm txhim kho cov kev cuam tshuam ntawm insulin, los yog potentiate tom kawg hauv thaj chaw ntawm cov chaw txais tos. Cov cuab yeej pab ua kom cov nqaij mos zoo ntxiv rau cov tshuaj insulin vim muaj qhov nce ntxiv ntawm cov insulin receptors nyob rau thaj tsam ntawm cov cell. Tsis tas li, metformin qeeb qeeb ua rau cov txheej txheem ntawm gluconeogenesis nyob rau hauv daim siab, txo cov roj oxidation thiab kev tsim cov roj ntsha dawb, txo cov ntshav triglycerides (TG), lipoproteins tsawg tsawg (LDL), thiab qis heev lipoproteins (VLDL) hauv cov ntshav. Metformin me ntsis txo qhov qab los noj mov thiab ua rau lub zog nqus ntawm cov carbohydrates hauv txoj hnyuv. Cov tshuaj pab txhawm rau txhim kho cov fibrinolytic yam ntxwv ntawm cov ntshav los ntawm kev txwv tsis pub rau cov nqaij mos plasminogen activator inhibitor.

Amaril M, cov lus qhia rau kev siv: kev ua thiab npaum li cas

Amaryl M noj ntawm qhov ncauj, nrog noj mov, 1 lossis 2 zaug ib hnub.

Cov koob tshuaj ntawm Amaril M yog txiav txim siab ib tus zuj zus nws nyob ntawm lub hom phiaj concentration ntawm cov piam thaj hauv cov ntshav. Nws raug nquahu kom siv cov tshuaj tiv thaiv kab mob rau cov tshuaj tiv thaiv kab mob hauv qis tshaj plaws, uas tso cai kom ua tiav qhov kev tswj hwm uas tsim nyog.

Thaum lub sijhawm kho cov tshuaj, nws yuav tsum tau ua ntu zus los tsim cov qib ntawm cov piam thaj hauv cov ntshav thiab zis, nrog rau feem pua ntawm glycosylated hemoglobin hauv cov ntshav.

Yog tias koj tau ua yuam kev noj cov tshuaj ntxiv, tsis muaj ib qho dab tsi yuav tsum tsis them nyiaj rau qhov sib txawv los ntawm kev siv txuas ntxiv ntawm qhov koob tshuaj ntau dua.

Yog tias hla kev noj mov lossis tshuaj lossis nyob rau qhov xwm txheej thaum tsis tuaj yeem noj Amaril M, tus neeg mob yuav tsum tsim txoj kev npaj ua ntej nrog tus kws kho mob.

Txij li kev txhim kho metabolic tswj yog txuam nrog kev muaj peev xwm ntau ntxiv rau cov kua dej mus rau insulin, qhov kev txo qis hauv qhov xav tau glimepiride yuav raug sau tseg thaum kho. Txhawm rau tiv thaiv qhov tshwm sim ntawm hypoglycemia, nws yuav tsum ua kom txo cov koob tshuaj ntawm Amaril M lossis tsum tsis noj tam sim ntawd.

Qhov siab tshaj plaws ib zaug tshuaj metformin yog 1000 mg, qhov siab tshaj plaws ib hnub yog 2000 mg. Qhov siab tshaj plaws txhua hnub koob ntawm glimepiride yog 8 mg. Qhov tshuaj txhaj ib zaug ntawm glimepiride ntau dua 6 mg rau ib hnub twg yuav zoo dua tsuas yog rau qee tus neeg mob tsawg.

Nyob rau hauv kis ntawm hloov tus neeg mob siv ua ke ntawm cov tib neeg npaj ntawm glimepiride thiab metformin rau Amaryl M, qhov koob tshuaj ntawm tom kawg tau tsim raws li cov koob tshuaj ntawm cov tshuaj nquag uas tus neeg mob tau noj. Yog tias nws tsim nyog yuav tau nce lub koob tshuaj, nws raug pom zoo kom them ib feem kaum ntawm cov tshuaj txhua hnub hauv kev nce ntawm tsuas yog 1 ntsiav tshuaj ntawm qhov ntau npaum li 1 mg + 250 mg lossis ½ ntsiav tshuaj Amaryl M 2 mg + 500 mg.

Lub chav kawm ntawm kev kho yog feem ntau ntev.

Cov lus qhia tshwj xeeb

Cov kab mob lactic acidosis yog ib qho mob uas tsis tshua pom muaj ntau, tab sis, cuam tshuam txog teeb meem ntawm kev zom zaub mov muaj mob (nrog kev tuag nyob rau qhov tsis muaj kev kho mob uas tsim nyog) tshwm sim los ntawm kev txuam nrog metformin thaum kho. Thaum noj cov tshuaj metformin, lactic acidosis feem ntau pom muaj ntshav qab zib mellitus nrog rau lub raum tsis ua haujlwm loj, nrog rau mob rau lub raum ua haujlwm thiab lub raum ntshav siab, feem ntau muaj ntau cov kab mob sib kis uas xav tau kev kho mob / phais mob. Cov teeb meem phom sij cuam tshuam nrog kev txhim kho ntawm cov kab mob lactic acidosis suav nrog: kev yoo mov ntev ntev, kev noj haus ntau ntawm cov cawv uas muaj cawv, ketoacidosis, tswj tsis tau ntshav qab zib mellitus, tej yam kev mob uas ua rau cov nqaij mos hypoxia, thiab lub siab tsis ua haujlwm. Cov kab mob lactic acid tuaj yeem tshwm sim nws tus kheej xws li hypothermia, mob plab, acidotic ua tsis taus pa ua raws li los ntawm kev pib ntawm coma. Qhov kev tsis txaus siab no yog suav nrog kev txo qis hauv cov ntshav pH, kev nce qib ntawm lactate hauv cov ntshav (ntau dua 5 mmol / l), qhov tsis txaus ntawm electrolyte nrog kev nce ntawm qhov tsis txaus ntawm anions thiab piv ntawm lactate / pyruvate. Yog tias metformin yog qhov ua rau cov kab mob lactic acidosis, nws cov ntshav feem ntau tshaj li 5 mcg / ml.

Yog tias muaj kev ua xyem xyav ntawm kev txhim kho ntawm cov kab mob lactic acidosis, nws yog ib qho sai uas yuav tsum tsis txhob noj cov tshuaj metformin thiab muab tus neeg mob tso rau hauv tsev kho mob.

Qhov kev hem thawj ntawm cov kab mob lactic acid yog exacerbated nrog ntau dua qhov mob tsis zoo los ua lub raum thiab nrog lub hnub nyoog. Txoj kev pheej hmoo ntawm tus mob no tuaj yeem txo los ntawm kev soj ntsuam lub raum tsis tu ncua thiab siv cov koob tshuaj metformin tsawg kawg. Nws tseem yog ib qho tseem ceeb kom ceev faj txog kev noj tshuaj rau hauv cov xwm txheej uas ua rau lub cev qhuav dej lossis mob hypoxemia.

Nrog cov chaw kho mob / kuaj mob tam sim no ntawm daim siab mob, Amaril M yuav tsum tsis txhob noj, vim tias kev muaj peev xwm tshem tawm lactate tuaj yeem txo qis tiv thaiv keeb kwm yav dhau los ntawm kev ua haujlwm tsis zoo hauv daim siab. Nws yuav tsum tso tseg kev siv tshuaj ib ntus ua ntej kev tshawb fawb nrog kev saib xyuas intravascular ntawm radiopaque tshuaj muaj iodine, thiab ua ntej muaj kev cuam tshuam kev kho mob. Metformin raug txwv tsis pub rau 48 teev ua ntej thiab 48 teev tom qab kev phais mob siv tshuaj loog xwb.

Nws yuav tsum tau yug los rau hauv lub siab tias lactic acidosis feem ntau muaj kev hloov maj mam tshwm sim thiab tsuas yog pom los ntawm cov tsos mob tsis zoo xws li kev noj qab haus huv tsis zoo, nce tsaug zog, myalgia, mob plab tsis muaj kev cuam tshuam, thiab ua pa nyuaj. Tawm tsam keeb kwm ntawm cov kab mob acidosis hnyav, txo qis ntshav siab, txo qis thiab tiv thaiv bradyarrhythmia tuaj yeem pom. Yog tias cov tsos mob zoo li no tshwm sim, koj yuav tsum sab laj nrog kws kho mob sai.

Lactic acidosis tuaj yeem kuaj pom hauv cov neeg mob ntshav qab zib mellitus nyob rau hauv kev muaj cov kab mob metabolic acidosis thiab tsis muaj ketonemia thiab ketonuria (cov cim ntawm ketoacidosis).

Nyob rau thawj lub asthiv ntawm kev kawm txog kev kho tshuaj, ua tib zoo saib xyuas cov ntshav qabzib ntau yog tsim nyog vim kev hem thawj ntawm lub qog ntshav qab zib, tshwj xeeb nrog kev pheej hmoo ntawm nws txoj kev loj hlob. Qee zaum, kev kho mob ntawm Amaril M lossis kev kho mob tag nrho yuav tsim nyog.

Cov tsos mob ntawm tus mob ntshav qab zib tsawg, kev xav txog adrenergic antihypoglycemic txoj cai, uas yog cov lus teb rau qhov tshwm sim hypoglycemia, tej zaum yuav mob sib khuav lossis tsis tuaj kiag li thaum muaj kev kawm paub tom kawg, zoo li nyob rau hauv cov neeg laus, thaum kev noj qab haus huv neuropathy lossis hauv kev kho ua ke nrog beta-adrenoblockers, guanethid clonidine thiab lwm yam sympatholytics.

Txhawm rau tswj cov hom phiaj glycemia, koj yuav tsum ua raws li kev noj haus, ua kom lub cev ua kom lub cev, txo lub cev nyhav, thiab yog tias tsim nyog, noj tshuaj tiv thaiv kab mob tsis tu ncua. Cov tsos mob ntawm kev tsis tuaj yeem ntshav ntshav glycemia yuav suav nrog: tawv nqaij qhuav, oliguria, nqhis dej, suav nrog pathologically muaj zog, thiab lwm tus.

Nws yuav luag txhua lub sijhawm ua kom sai sai kom tsis txhob mob ntshav qab zib nrog kev noj sai ntawm carbohydrates - qab zib lossis qabzib, piv txwv li, ib qho qab zib, tshuaj yej nrog piam thaj, kua txiv hmab txiv ntoo muaj suab thaj, thiab lwm yam rau lub hom phiaj no, tus neeg mob yuav tsum ib txwm muaj tsawg kawg 20 g suab thaj , hloov los rau cov tom kawg ua tsis tau zoo.

Thaum kho, nws pom zoo kom saib xyuas qib ntshav hemoglobin / hematocrit tsawg kawg, cov qe ntshav liab tsawg, nrog rau cov cim ntsuas raum kev ua haujlwm (ntshav creatinine hauv cov ntshav): tsawg kawg 1 zaug hauv ib xyoos - nrog lub raum tsis ua haujlwm, tsawg kawg 2-4 zaug hauv ib xyoos - cov ntaub ntawv ntawm ntshiab CC ntawm kev txwv sab sauv ntawm ib txwm thiab hauv cov neeg laus.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Hauv kev kho mob, feem ntau thaum pib mus txog thaum kawg, lub sijhawm hloov ntawm ib qho yeeb tshuaj mus rau lwm qhov lossis siv tsis haum ntawm Amaril M, qhov kev poob qis ntawm cov tshuaj tiv thaiv tuaj yeem raug sau tseg. Thaum tsav tsheb lub tsheb lossis lwm cov txheej txheem txav mus los nyuaj thaum lub sij hawm kho, yuav tsum saib xyuas, tshwj xeeb yog tias muaj qhov nyiam ntshav qis thiab / lossis qhov txo qis ntawm qhov hnyav ntawm nws tus ua ntej.

Cev xeeb tub thiab lactation

Amaryl M yog contraindicated thaum cev xeeb tub vim muaj kev cuam tshuam tsis zoo rau kev loj hlob ntawm tus me nyuam hauv plab. Thaum cev xeeb tub tshwm sim los yog npaj ua ntej, cov neeg mob yuav tsum qhia rau tus kws kho mob uas koom nrog.

Cov poj niam muaj lub cev metabolism hauv lub cev tsis txaus, uas tsis tuaj yeem hloov kho tsuas yog noj zaub mov zoo thiab tawm dag zog, yuav tsum yog cov tshuaj insulin kho.

Txhawm rau kom tsis txhob muaj cov tshuaj tua kab mob tiv thaiv kab mob nrog niam mis rau hauv tus menyuam lub cev, kev siv Amaril M thaum lactation yog contraindicated. Yog tias nws yuav tsum tau kho kho tus mob ntshav qab zib tsawg, tus neeg mob yuav tsum hloov mus rau kev kho tshuaj insulin lossis tsis pub mis niam.

Nrog lub raum tsis ua haujlwm

Amaril M yog qhov teeb meem pom tseeb ntawm tus neeg mob lub raum lub raum thiab lub raum tsis ua haujlwm. Ntshav dej muaj cov cim ≥ 1.2 mg / dL (110 μmol / L) hauv cov poj niam thiab ≥ 1.5 mg / dL (135 μmol / L) rau cov txiv neej, lossis txo qis hauv CC los ntawm yog vim li cas rau kev tsim txom ntawm kev hem thawj ntawm lactic acidosis thiab lwm yam kev phiv tshuaj ntawm metformin. Kev kho mob nrog cov tshuaj kuj yog contraindicated rau cov neeg mob ntawm hemodialysis, thiab nyob rau hauv lub xub ntiag ntawm mob mob hnyav uas tuaj yeem ua rau lub raum tsis ua hauj lwm, xws li intravascular tswj hwm ntawm iodinated kev sib piv cov neeg sawv cev, mob sib kis mob hnyav, lub cev qhuav dej, poob siab.

Siv rau lub sijhawm qub

Vim tias qhov pheej hmoo ntawm cov kab mob lactic acidosis thiab lwm yam kev tsis zoo ntawm cov tshuaj metformin, cov neeg laus cov neeg mob yuav tsum siv Amaril M nrog kev ceev faj (vim tias muaj feem ntau txo qis hauv lub raum ua haujlwm), tshwj xeeb tshaj yog nyob rau hauv cov kev mob uas ua rau lub raum tsis ua haujlwm, xws li pib kho nrog diuretics, tshuaj tiv thaiv kab mob, as Well as NSAIDs. Cov koob tshuaj yuav tsum ua tib zoo them thiab saib xyuas lub raum kev ua haujlwm yuav tsum tau nqa tawm.

Kev txheeb xyuas txog Amarila M

Raws li kev tshuaj xyuas ntawm Amaril M, cov tshuaj yog qhov ua haujlwm zoo hypoglycemic uas muab txo qis hauv cov concentration ntawm cov piam thaj hauv cov ntshav thiab nws cov txij nkawm nyob rau theem nyab xeeb. Cov neeg mob nco ntsoov tias txhawm rau kom tau txais txiaj ntsig zoo ntawm kev kho, nws kuj yuav tsum ua raws li kev noj zaub mov kom tsim nyog thiab tau txais kev ua si kom txaus.

Qhov tsis zoo ntawm cov tshuaj, raws li kev txheeb xyuas, yog coob leej ntawm contraindications, zoo li qhov tshwm sim tsis zoo uas feem ntau tshwm sim thaum kho. Ntau tus neeg mob tsis txaus siab rau tus siab, hauv lawv qhov kev xav, Amaril M. nqi.

Pharmacological kev txiav txim

Glimepiride muaj cov nyhuv hypoglycemic rau ntawm lub cev. Nws yog ib qho muab sib txuas ntawm peb tiam sulfonylurea.

Amaryl muaj cov ntsiab lus ncua ntev. Thaum cov ntsiav tshuaj siv, tus kws kho mob txiav lub siab, thiab beta-cells qhib kom ua haujlwm. Raws li qhov tshwm sim, insulin pib tawm ntawm lawv, cov tshuaj hormone nkag mus rau hauv cov hlab ntshav. Qhov no pab txo qis cov piam thaj tom qab noj mov.

Tib lub sijhawm, glimepiride muaj cov nyhuv ntxiv. Nws tsub kom rhiab ntawm cov leeg, cov nqaij rog ua rau cov insulin. Thaum siv cov tshuaj, cov tshuaj tiv thaiv kev phom sij, antiatherogenic, cov nyhuv antiplatelet yog pom.

Amaril txawv ntawm lwm cov sulfonylurea derivatives uas thaum nws siv, cov ntsiab lus ntawm tso tawm insulin yog qis dua thaum siv lwm cov tshuaj hypoglycemic. Vim qhov no, txoj kev pheej hmoo ntawm hypoglycemia muaj tsawg heev.

Ntxiv dag zog rau cov txheej txheem ntawm kev siv cov piam thaj hauv cov nqaij thiab cov nqaij ua kom rog tuaj yeem ua tau vim muaj qhov tshwj xeeb thauj cov protein nyob hauv cov cell ua cov qog. Amaryl tsub kom lawv cov haujlwm ntau ntxiv.

Cov tshuaj yeeb yaj kiab tsis thaiv ATP-nkag siab poov tshuaj raws ntawm plauv nres myocytes. Lawv tseem muaj txoj hauv kev hloov kho rau cov mob ischemic.

Amaryl kev kho mob thaiv kev tsim cov kua nplaum los ntawm lub siab ua haujlwm. Cov txiaj ntsig tau taw qhia yog vim muaj cov ntsiab lus nce ntxiv ntawm fructose-2,6-biophosphate hauv hepatocytes. Qhov tshuaj no nres gluconeogenesis.

Cov tshuaj pab txhawm rau txhawm rau txhawm rau lub zog ntawm cyclooxygenase, kom txo cov txheej txheem ntawm kev hloov pauv ntawm thromboxane A2 los ntawm arachidonic acid. Vim tias qhov no, kev siv ntawm platelet aggregation tsawg dua. Hauv qab ntawm Amaril, qhov hnyav ntawm cov tshuaj tiv thaiv oxidative, uas tau pom hauv cov ntshav qab zib tsis yog-insulin, txo qis.

Sau tshuaj rau cov tshuaj glimepiride rau cov neeg mob uas muaj tus mob II, yog tias kev siv lub cev, kev noj haus tsis tso cai rau koj tswj qib qab zib.

Cov lus qhia rau kev siv qhia tau tias nws raug tso cai rau kev sib xyaw ua ke siv tshuaj Amaril nrog metformin, kev txhaj tshuaj insulin.

Dr. Bernstein pom zoo tias kev teem sijhawm rau cov neeg sawv cev hypoglycemic tsis yog qhov muaj tseeb, txawm tias muaj qhov qhia tau rau kev siv. Nws hais tias cov tshuaj muaj teeb meem, txhim kho cov teeb meem hauv lub cev hauv lub cev tsis ua haujlwm. Txhawm rau qhov xwm txheej kom zoo, koj tuaj yeem siv tsis yog sulfonylurea derivatives, tab sis kev noj zaub mov hauv kev sib xyaw nrog kev kho tshwj xeeb.

Cov lus qhia rau kev siv

Coj Amaryl raug tso cai los ntawm kev teem caij ntawm tus kws kho mob tuaj koom. Tus kws kho mob tshwj xeeb yuav xaiv qhov pib muab rau txhua tus neeg mob tus kheej. Nws nyob ntawm cov concentration ntawm cov piam thaj hauv cov ntshav, cov kev siv ntawm kev tawm suab thaj hauv cov zis.

Thaum pib kho, nws raug nquahu kom haus cov ntsiav tshuaj uas muaj 1 mg ntawm glimepiride. Nce qhov tshuaj zuj zus. 2 mg ntsiav tshuaj tau pauv tsis dhau los ua ntej 1-2 lub lis piam tom qab pib kho. Nyob rau theem pib, tus kws kho mob tswj hwm tus neeg mob lub sijhawm, nyob ntawm seb cov tshuaj tiv thaiv, hloov kho txoj kev kho. Qhov siab tshaj plaws pub niaj hnub noj yog 6-8 mg ntawm glimepiride.

Yog tias qhov txiaj ntsig kho qhov xav tau tsis tuaj yeem ua tau txawm tias thaum noj ntau ntau tso cai ntawm Amaril, ces cov tshuaj insulin ntxiv rau.

Nws yog ib qho tsim nyog yuav tsum noj cov ntsiav tshuaj ua ntej noj mov tseem ceeb 1 zaug hauv ib hnub. Cov kws kho mob pom zoo kom haus cov tshuaj ua ntej noj tshais. Yog tias tsim nyog, nws raug tso cai hloov lub sijhawm txais tos rau noj su.

Tsis kam noj zaub mov tom qab Amaril yog qaug cawv yog txwv tsis pub. Tom qab tag nrho, qhov no yuav ua rau poob qis hauv cov piam thaj. Kev mob ntshav qab zib tuaj yeem ua rau lub ntsej muag mob hlwb, ua rau mob ntshav qab zib tsis xeev, tuag.

Cov ntsiav tshuaj yog nqos tag nrho yam tsis muaj ntxo.

Kev sib txuam

Ua ntej muab cov tshuaj Amaryl, tus kws kho mob yuav tsum xyuas seb cov tshuaj twg tus neeg mob tau noj. Qee cov tshuaj txhim kho, lwm tus txo cov nyhuv hypoglycemic ntawm glimepiride.

Thaum ua kev tshawb fawb, nws pom tias qhov txo qis hauv cov ntshav qab zib tau pom thaum noj:

cov tshuaj tiv thaiv kab mob hauv qhov ncauj
Phenylbutazone
Oxyphenbutazone,
Azapropasone
Sulfinpyrazone,
Metformin
Tetracycline
Miconazole
salicylates,
MAO inhibitors
txiv neej nrog txiv neej cov tshuaj hormones
anabolic tshuaj yuam
quinol tshuaj tua kab mob,
Clarithromycin
Fluconazole
pab daws qhov teeb meem,
fibrates.

Yog li, nws tsis pom zoo kom pib haus Amaryl ntawm koj tus kheej yam tsis tau txais kev tsim nyog los ntawm kws kho mob.

Cov kab mob hauv qab no tsis muaj zog ntawm glimepiride:

progestogens
estrogens
thiazide diuretics,
tshuaj pleev
glucocorticoids,
nicotinic acid (thaum siv ntau koob),
laxatives (muab lub sij hawm ntev siv),
barbiturates
Rifampicin,
Glucagon.

Cov nyhuv no yuav tsum tau coj mus rau hauv tus account thaum xaiv ntau npaum.

Sympatolytics (beta-blockers, reserpine, clonidine, guanethidine) muaj qhov tshwm sim uas tsis paub meej txog qhov cuam tshuam hypoglycemic ntawm Amaril.

Thaum siv coumarin derivatives, ceeb toom: glimepiride ua kom zoo dua qub lossis txo qhov cuam tshuam ntawm cov tshuaj no rau hauv lub cev.

Tus kws kho mob xaiv cov tshuaj rau ntshav siab, tsis-steroidal anti-inflammatory tshuaj, thiab lwm yam tshuaj uas nrov.

Amaryl ua ke nrog cov tshuaj insulin, metformin. Qhov kev sib xyaw no yog xav tau thaum thaum noj glimepiride nws tsis tuaj yeem ua kom tiav qhov kev xav tau tswj kev zom zaubmov. Qhov ntau thiab tsawg ntawm txhua yam tshuaj yog kws kho mob tau teev tseg.

Hauv qee kis, cov kws kho mob pom zoo kom haus cov dej Yanumet thiab Amaril tib lub sijhawm. Nrog rau txoj kev kho no, tus neeg mob tau txais:

Cov kev sib xyaw ua ke ntawm cov khoom xyaw nquag tuaj yeem txhim kho txoj hauv kev ntawm kev kho, pab tswj tau qhov mob zoo dua rau tus mob ntshav qab zib.

Hnub tas sij hawm

Siv cov tshuaj yog tso cai rau 36 lub hlis txij li hnub tso tawm.

Qhov tsim nyog endocrinologist yuav tsum xaiv qhov hloov pauv txoj cai rau Amaryl. Nws tuaj yeem sau tshuaj ib qho analogue ua tau los ntawm cov khoom zoo tib yam, lossis xaiv cov tshuaj uas ua los ntawm lwm cov khoom siv.

Cov neeg mob tuaj yeem sau npe yuav hloov kho Lavxias, Diamerid, uas yog pheej yig. Rau 30 ntsiav tshuaj ntawm cov tshuaj, ua rau lub hauv paus ntawm glimepiride, nrog cov tshuaj ntawm 1 mg rau hauv lub tsev muag tshuaj, cov neeg mob yuav them 179 p. Nrog kev kub siab rau kev saib xyuas ntawm cov tshuaj nquag, tus nqi nce ntxiv. Rau diamerid hauv ib qho tshuaj 4 mg, 383 p.

Yog tias tsim nyog, hloov Amaryl nrog cov tshuaj Glimepiride, uas yog tsim los ntawm cov tuam txhab Lavxias teb sab Vertex. Cov ntsiav tshuaj uas hais qhia yog pheej yug. Rau ntim ntawm 30 pcs. 2 mg yuav tau them 191 p.

Tus nqi ntawm Glimepiride Canon, uas tsim los ntawm Canonfarm, kuj tseem qis dua. Tus nqi ntawm ib pob ntawm 30 ntsiav tshuaj ntawm 2 mg yog suav tias yog pheej yig, nws yog 154 p.

Yog tias glimepiride tsis qaug rau, cov neeg mob tau kho lwm yam tshuaj ntxiv raws ntawm metformin (Avandamet, Glimecomb, Metglib) lossis vildagliptin (Galvus). Lawv raug xaiv coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob lub cev.

Cawv thiab Amaryl

Nws tsis tuaj yeem kwv yees ua ntej li cas haus cawv muaj cawv yuav cuam tshuam rau tus neeg uas siv tshuaj yaj yeeb raws li glimepiride. Cov cawv yuav ua rau lub cev tsis muaj zog lossis txhim kho hypoglycemic ntawm Amaril. Yog li, lawv tuaj yeem siv tsis tau tib lub sijhawm.

Kev siv tshuaj hypoglycemic nyob ntev. Vim tias qhov no, txoj cai txwv tsis pub haus cawv haus cawv ntau rau ib qho yuav dhau los ua teeb meem.

Cev xeeb tub, lactation

Yuav siv tsis tau lub sij hawm thaum xeeb tus me nyuam hauv plab nruab cev, pub mis noj rau tus me nyuam yug tshiab, sulfonylurea derivatives yuav siv tsis tau. Hauv cov ntshav ntawm tus poj niam cev xeeb tub, cov kua nplaum nyob hauv lub cev yuav tsum tsis pub dhau. Tom qab tag nrho, hyperglycemia ua rau kev nce hauv kev pheej hmoo ntawm kev tsis txaus ntseeg lub neej tom qab, nce tus menyuam kev tuag ntau dua.

Cov poj niam cev xeeb tub tau pauv mus rau cov tshuaj insulin. Nws yog qhov ua tau kom tshem tawm qhov tshwm sim ntawm kev siv tshuaj phiv rau ntawm tus menyuam hauv utero yog tias koj tso sulfonylurea nyob rau theem ntawm kev npaj lub tswv yim.

Thaum lub sijhawm lactation, Txoj kev kho Amaril yog txwv tsis pub. Cov tshuaj nquag kis mus rau niam mis, lub cev ntawm tus menyuam yug tshiab. Thaum pub niam mis, nws yog qhov tsim nyog kom tus poj niam hloov mus rau kev siv tshuaj insulin.

Rau ntau tus neeg mob, kev pom zoo ntawm tus kws kho endocrinologist tsis txaus kom pib haus ib yam tshuaj tshiab. Cov kws kho mob hais tias cov tshuaj pab rau cov neeg ua haujlwm kom tsim cov tshuaj insulin, thaum nce ntxiv rhiab ntawm cov ntaub so ntswg mus rau nws. Qhov no ua rau kom pom tseeb tias cov piam thaj tau pib nqus nws lub cev.

Tab sis cov neeg mob xav hnov qhov kev xav txog cov tshuaj kws kho mob los ntawm lwm cov ntshav qab zib. Lub siab xav paub txog kev tshuaj xyuas ntawm lwm tus neeg mob vim yog tseem muaj nqi ntau ntawm cov tshuaj. Tom qab tag nrho, nws muaj ntau yam tshuaj ntawm kev muag khoom uas tau tsim los txo cov piam thaj hauv siab, tus nqi ntawm uas tau nqis qis dua.

Thaum noj Amaril rau 1-2 xyoo, tsis muaj qhov tsis zoo tshwm sim.Kev xyaum qhia tau tias ob peb ntsib teeb meem thaum siv cov tshuaj. Ntau zaus, teeb meem tshwm sim thaum Amaril M siv rau kev kho mob, uas ntxiv rau glimepiride suav nrog metformin. Cov neeg mob yws yws ntawm lub cev ua pob, ua pob khaus ntawm daim tawv nqaij, ua kom tawg. Tom qab siv cov ntsiav tshuaj, qee cov neeg xav tias muaj kev kub ntxhov hypoglycemic nce mus txog, txawm hais tias thaum kuaj xyuas nws hloov tawm tias qhov txo qis cov piam thaj tsis tseem ceeb.

Hauv thawj lub hlis ntawm kev siv, glimepiride npaj zoo kawg nkaus txo qis qab zib. Tab sis qee tus kws kho mob tau sau tseg tias qhov ua tau zoo ntawm cov tshuaj pib qhuav zuj zus thaum lub sijhawm dhau mus. Tus neeg mob yog thawj zaug nce ntxiv qhov ntau npaum li cas, thiab tom qab ntawd ua ke los ntawm kev siv tshuaj yog kho. Nov yog tib txoj hauv kev kom ua tiav lub xeev ib ntus. Tab sis vim tias qhov txo qis hauv txoj hauv kev kho tau zoo, tus neeg mob tau nce siab nyob hauv qab zib hauv lub cev. Qhov no ua rau muaj kev cuam tshuam dav dav.

Nrog kev pab los ntawm Amaril, qee tus neeg mob ntshav qab zib tau maj mam tau txais ntawm qhov xav tau los ua cov tshuaj insulin tas li. Txawm hais tias thaum pib ntawm kev kho mob, ntau tus neeg muaj cov tsos mob ntawm lub qog ntshav qab zib. Cov neeg mob yws txog xeev siab, ua tsis taus tes, dias taub hau, muaj kev tshaib plab tas li. Maj mam, qhov mob hloov kho, qhov tsis zoo tshwm sim ploj.

Nqe, qhov twg yuav

Amaryl ntsiav tshuaj muaj muag hauv yuav luag txhua txhua lub tsev muag tshuaj. Tus nqi ntawm ib pob ntawm 30 daim ncaj qha nyob ntawm kev muab tshuaj pom zoo los ntawm kws kho mob.

Tus nqi ntawm mg glimepiride	Tus nqi, tshiav.
1	348
2	624
3	939
4	1211

Pob khoom ntawm 90 ntsiav tshuaj muaj muag. Yog tias koj yuav Amaril nyob rau hauv xws li pob, koj yuav txuag tau me ntsis. Txhawm rau ntim khoom ntawm 90 daim (2 mg) koj yuav tsum them 1728 p.

Tus neeg mob ntshav qab zib kuj tseem yuav tau qhia kom saib xyuas tus nqi hauv cov chaw muag tshuaj sib txawv. Amaryl qee zaum muag thaum luv nqi.

Cov Tshuaj Pharmacokinetics

Raug rho tawm los ntawm cov hnyuv kom meej thiab sai. 98% ua txhua yam rau cov protein. Kev noj tsis cuam tshuam rau kev nqus. Nws yog txiav txim siab nyob rau hauv niam cov kua mis thiab hla lub tsho me nyuam. Kev mob plab zom mov tshwm sim hauv lub siab nrog kev tsim cov khoom ua tsis voos. Yog tias kev ua haujlwm ntawm lub raum ua tsis tau zoo, cov tshuaj cuam tshuam tsis muaj zog rau cov roj ntsha ntshav thiab muaj feem cuam sai hauv cov zis. Tsis txuam hauv cov ntaub so ntswg. Nws yog tawm hauv cov hnyuv thiab raum.

Metformin nqus tau nrawm. Tsis khi rau cov nqaijrog. Txoj kev pheej hmoo ntawm kev txuam nrog ib yam khoom hauv lub cev hauv cov neeg mob uas lub raum tsis ua haujlwm nce siab. Nws tawm hauv cov zis.

Yog tias kev ua haujlwm ntawm lub raum ua tsis tau zoo, cov tshuaj cuam tshuam tsis muaj zog rau cov roj ntsha ntshav thiab muaj feem cuam sai hauv cov zis.

Nrog saib xyuas

Ceev faj yuav tsum tau siv thaum siv cov ntsiav tshuaj nyob rau hauv xws li mob:

kev noj zaub mov tsis xwm yeem
kev ua neej nyob ntsiag to
tsis mob ua rau cov qog,
hnub nyoog siab heev
lub cev ua haujlwm hnyav
piam thaj-6-phosphate dehydrogenase tsis txaus.

Nyob rau hauv qhov muaj cov kabmob uas ua rau mob nyav ntawm mob ntshav qab zib mellitus, nws yog qhov yuav tsum tau kho cov tshuaj ntau npaum thiab soj ntsuam cov ntshav ntawm glycemia.

Qhov tshwm sim ntawm Amaril 500

Amaryl 500 tuaj yeem ua rau ntau cov kev mob tshwm sim los ntawm cov leeg poob siab - tsaug zog, tsis nco qab, thiab insomnia.

Cov tshuaj yog tus cwj pwm tshwm sim los ntawm cov kev mob tshwm sim los ntawm lub hauv nruab siab poob siab hauv daim ntawv ntawm insomnia.

Los ntawm ib sab ntawm cov metabolism

Cov tsos mob tshwm sim los ntawm ib sab ntawm cov metabolism - mob taub hau, kiv taub hau, tsis tuaj yeem muaj peev xwm mloog lus tsis txaus, tsaus muag, tshee tshee, mob plab, mob plab, muaj zog nce, tawm hws. Cov cim qhia pom kev txhim kho hypoglycemia.

Urticaria, pruritus, tawm pob, anaphylactic poob siab.

Ua xua uas tshwm sim tom qab siv tshuaj muaj xws li: khaus thiab tawm pob.

Cawv tau zoo

Kev haus cawv ua rau muaj kev txhim kho hauv qhov tsis xav ua. Nyob hauv kev cuam tshuam ntawm ethanol, cov piam thaj hauv qab yuav poob rau theem tseem ceeb. Qhov sib txig sib xyaw ntawm cov tshuaj nrog cawv muaj feem ua rau tus neeg mob siab thiab lub raum ua haujlwm tsis zoo.

Muaj cov analogues rau pharmacological ua:

Cov lus qhia qhia contraindications thiab phiv. Ua ntej hloov nrog txoj kev kho zoo li no, nws zoo dua rau koj mus ntsib koj tus kws kho mob.

Amaril M kev qhia Galvus Cov kev qhia Glimecomb kev qhia

Amaril 500 Xyuas

Marina Sukhanova, kws kho mob tshuaj tua kab, Irkutsk

Cov tshuaj rau ib qho tsawg dua li lwm qhov kev tiv thaiv kab mob ntshav qab zib ua rau cov tshuaj insulin tsawg zuj zus. Ntxiv rau, cov tshuaj tau txais txiaj ntsig zoo los ntawm cov neeg mob (suav nrog kev txo qis ntawm hypoglycemia). Cov tshuaj me ntsis txo qhov qab los noj mov. Zoo rau cov neeg mob uas tsis muaj cov ntshav qab zib-insulin-tsis muaj ntshav qab zib.

Maxim Sazonov, tus kws kho mob endocrinologist, Kazan

Cov khoom siv ua ke ua ke sib txuam rau txhua tus nqis tes ua. Metformin txhim kho cov cuam tshuam ntawm glimepiride. Hauv cov ntshav muaj txo cov ntshav qabzib, LDL thiab triglycerides. Ib qho cuab yeej zoo tshaj plaws rau kev tswj hwm cov kua nplaum ib txwm. Kev phiv tshuaj tuaj yeem tshwm sim nyob rau hauv daim ntawv ntawm kev ua xua, hypoglycemia, pw ntxhov.

Marina, 43 xyoo, Samara

Hauv hom 2 Ntshav Qab Zib, cov tshuaj zoo nrog cov sib xyaw ua ke tau raug muab tshuaj. Nws tiv thaiv kev txhim kho ntawm hyperglycemia thiab tsis coj mus rau hypoglycemia, yog tias qhov tsim nyog tau tshuaj yog txhawm rau. Thawj ob peb lub lis piam, nws hnov mob xeev siab, thiab tom qab ntawd mob plab zawv. Cov tsos mob ploj mus rau lub sijhawm, thiab tam sim no kuv tsis hnov qhov tsis xis nyob.

Analogs Amaryl M, tus nqi hauv khw muag tshuaj

Yog tias tsim nyog, hloov Amaryl M 2mg + 500mg, qhov no tuaj yeem ua tiav nrog cov tshuaj analogue hauv kev kho mob - cov no yog cov tshuaj:

Thaum xaiv cov analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv Amaryl M, tus nqi thiab tshuaj xyuas, tsis txhob siv rau cov tshuaj ntawm cov nyhuv zoo sib xws. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.