Acarbose rau ntshav qab zib
1S- (1alpha, 4alpha, 5beta, 6alpha) -0-4,6-dideoxy-4-4,5,6-trihydroxy-3- (hydroxymethyl) -2-cyclohexen-1-ylamino-alpha-D-glucopyranosyl- (1-4) -0-alpha-D-glucopyranosyl- (1-4) -D-piam thaj lossis (2R, 3R, 4R, 5S, 6R) -5- (2R, 3R, 4R, 5S, 6R) - 5- (2R, 3R, 4S, 5S, 6R) -3,4-dihydroxy-6-methyl- 5- (1S, 4R, 5S, 6S) - 4,5,6-trihydroxy-3- (hydroxymethyl) cyclohex-2-en-1-ylaminooxan-2-yloxy-3,4-dihydroxy-6- (hydroxymethyl) oxan-2-yloxy-6- (hydroxymethyl) oxan-2,3,4-triol (IUPAC).
Tshuaj lom neeg thaj chaw
Carbohydrate los ntawm pawg oligosaccharides Acarbose yog hmoov, dawb lossis dawb nrog ib qho ntxoov ntxoo, uas yog soluble heev hauv dej. Cov khoom siv tau los ntawm Actinoplanes utahensis siv cov ntawv fermentation. Lub phaus molecular ntawm lub tshuaj sib txuas yog 645.6 grams tauj ib mole. Cov tshuaj tau tawm hauv daim ntawv ntawm cov ntsiav tshuaj, hauv qhov tshuaj ntawm 50 lossis 100 mg.
Pharmacodynamics thiab pharmacokinetics
Lub cuab yeej tawm oligo thiab polysaccharides hydrolysis cov tshuaj tiv thaiv los ntawm kev sib tw inhibition ntawm pancreatic alpha amylases thiab hnyuv membrane-khi ua alpha glucosidasesCov. Hauv qab ntawm acarbose, lub lumen ntawm txoj hnyuv me tsoo kom ploj cov, oligo thiab trisaccharides rau ntau yam monosaccharides thiab piam thaj. Kev siv ntawm kev tsim thiab nqus ntawm cov piam thaj hauv cov hnyuv poob qis, cov piam thaj ntawm cov piam thaj hauv cov ntshav yuav cuam tshuam ntev li qub. Cov tshuaj tsis txhawb kev ua kom nce zuj zus tshuaj insulin thiab tsis coj mus rau ntshav qog.
Cov tshuaj yeeb yaj kiab tsis yog hloov mutagenic, tsis cuam tshuam rau lub cev xeeb tub thiab kev muaj peev xwm cov me nyuam raws li tag nrho.
Nrog cov kev tswj hwm ntawm kev tswj hwm ntawm cov tshuaj hauv cov neeg mob uas muaj kev tiv thaiv tsis zoo qabzib, muaj kev pheej hmoo ntshav qab zib hom 2, myocardial infarction thiab kab mob plawv.
Acarbose muaj cov neeg kawm ntawv qis qis qis, nrog txog 35%. Lub bioavailability ntawm qhov kev txiav txim ntawm 1-2%. Qhov siab tshaj plaws ntawm cov tshuaj nws tus kheej tau pom nyob hauv cov ntshav ib teev tom qab kev tswj hwm, thiab nws cov khoom noj tshuaj - tom qab 14 teev - ib hnub.
Hauv cov neeg uas mob raum tsis ua haujlwm, qhov siab tshaj plaws siab tshaj plaws nce txog 5 zaug, hauv cov neeg laus cov neeg mob qhov ntsuas no nce txog 1.5 zaug.
Cov tshuaj no metabolized nyob rau hauv cov hnyuv nrog kev koom tes ntawm cov kab mob hauv plab hnyuv thiab ua kom cov zom plab, kwv yees li 13 metabolites muaj nyob hauv Acarbose. Cov no yog feem ntau derivatives 4-methylpyrogallolCov. Cov tshuaj tsis hloov pauv (kwv yees li ib nrab ntawm cov koob tshuaj) tau tawm hauv cov quav hauv 96 teev. Kwv yees li 35% ntawm cov tshuaj tau tawm hauv cov qauv ntawm cov metabolites los ntawm ob lub raum. Qhov kev tshem tawm ib nrab-lub neej yog 4 teev (kev xa tawm theem) thiab mus txog 10 teev (qib kev zam).
Cov Yuav Tsum Tau Ua
Cov tshuaj yog contraindicated rau hauv kev noj:
- ntawm ua xua rau acarbose
- cov neeg mob nrog mob ketoacidosis, mob ntsws,
- nyob rau hauv kev mob plab thiab mob ua paug plab hnyuv, nrog cov mob plab zom thiab nqus tau,
- mob nrog Tsa ntawv pov thawj cov tsos mob,
- lactating poj niam
- nrog pathologies ntawm lub plab zom mov, nrog los ntawm ulcerative mob plab, flatulenceplab hnyuv ob leeg (suav nrog ib nrab),
- cov neeg mob nrog nruj thiab mob plab hnyuv, mob hnyuv loj,
- nyob rau hauv ntev lub raum tsis ua hauj lwm,
- thaum ntawm cev xeeb tub.
Ceev faj yog qhia thaum noj Acarbose:
- cov neeg mob uas muaj kab mob, raug mob, tom qab phais mob,
- muaj peev xwm npaws,
- cov hnub nyoog qis dua 18 xyoo.
Sab sij huam
Feem ntau cov kev phiv tshuaj los ntawm tus mob huam:
- cov roj muaj zog ntxiv, zawv plabmob hauv plab, ntuav, kem plab,
- xeev siab, ua tiav lossis ib feem ntawm txoj hnyuv tawm tsam,
- dajntoo, nce kev ua si ntawm daim siab enzymes, kab mob siab.
Kuj hais tias: o, thrombocytopenia, urticariadaim tawv nqaij ua pob, erythema.
Acarbose, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)
Cov ntsiav tshuaj tau noj ntawm qhov ncauj, 20 feeb ua ntej noj mov lossis ib teev tom qab noj mov.
Thaum pib theem ntawm kev kho mob, 50 mg ntawm cov tshuaj siv 3 zaug ib hnub, tom qab ntawd cov tshuaj yog maj mam nce mus rau 0.1-0.2 grams, nyob ntawm kev thev taus.
Qhov nruab nrab, muab tshuaj rau cov neeg mob hnyav dua 60 kg yog 50 mg, ntau dua 60 kg yog 300 mg rau ib hnub. Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 0.6 grams.
Txog kev tiv thaiv, cov tshuaj tau tawm ntawm 50 mg rau ib hnub, thiab maj mam nce mus rau 0.1 grams dhau 3 lub hlis.
Kev sib txuam
Cov nyhuv ntshav tsis txaus (hypoglycemic effect) ntawm cov tshuaj yog txhim kho los ntawm kev nqis tes ua los ntawm derivatives sulfonylureas, metformin, tshuaj insulin.
Colestyramine, tshuaj tiv thaiv kab mob thiab cov adsorbents uas muaj nyob rau hauv txoj hnyuv, txo cov txiaj ntsig ntawm kev kho nrog Acarbose.
Glucocorticosteroids, estrogenscov thyroid hormones, thiazide diuretics, phenothiazines, phenytointshuaj tiv thaiv qhov ncauj nicotinic acid, isoniazid, adrenostimulants thiab lwm yam tshuaj uas ua rau ntshav qog txo qhov kev ua haujlwm ntawm cov tshuaj, nce mus txog decompensation mob ntshav qab zib mellitus.
Cov lus qhia tshwj xeeb
Thaum kho nrog tshuaj, nws yog ib qho tsim nyog ua raws li cov lus pom zoo los ntawm tus kws kho mob, ua raws kev noj haus. Dej qab zib thiab zaub mov uas muaj cov carbohydrates thiab qab zib tuaj yeem ua rau mob plab hnyuv.
Thaum kho, nws kuj tseem pom zoo tswj ntshav qab zib thiab ntshav qab zib kom tsawg glycosylated hemoglobin thiab transaminases, tshwj xeeb tshaj yog nyob rau hauv thawj 12 lub hlis ntawm kev kho mob.
Nrog rau qhov koob tshuaj nce ntau dua 0.3 grams hauv ib hnub, qhov mob me me yuav tshwm sim hyperglycemia thiab qhov pheej hmoo siab ntxiv hyperfermentemia.
Thaum kho nrog cov khoom lag luam, nws yuav tsum nco ntsoov tias cov khoom noj qab zib zoo tib yam tau zom qis thiab tsis muaj peev xwm tshem tawm sai sai ntshav qogCov. Txhawm rau tshem tawm cov mob no, nws raug nquahu kom siv cov koob tshuaj ntau piam thaj (tsis sucrose), dua li intravenously.
Cov tshuaj, raws li txoj cai tsis raug samfwm rau cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Npaj uas muaj (Ib Leeg)
Kev tshuaj xyuas ntawm cov tshuaj rau kev tawm tsam mob ntshav qab zib feem ntau zoo. Qhov tshwm sim feem ntau thiab teeb meem tshwm sim yog cov roj ntau ntau thiab lub plab tsis xis nyob. Kev txheeb xyuas txog Acarbose rau poob phaus tau muab faib. Cov tshuaj no tsim nyog rau ib tug neeg, thiab ib tug neeg tom qab noj tshuaj pib nquag noj cov khoom qab zib thiab plam tswj. Nws yuav tsum raug sau tseg tias thaum kho nws yog qhov tsim nyog yuav tsum ua raws li kev noj haus, txwv tsis pub, qhov ua tau zoo ntawm kev kho yog txo qis.
Acarboza nqe qhov twg yuav
Tus nqi ntawm Glucobai ntsiav tshuaj yog txog 560 rubles rau 30 daim, nrog muab tshuaj ntawm 100 mg.
Kev Kawm: Nws kawm tiav hauv Rivne State Basic Medical College nrog kev kawm tiav qib hauv Tshuaj. Nws kawm tiav hauv Vinnitsa State Medical University. M.I. Pirogov thiab ib qho kev xyaum ua haujlwm raws nws.
Kev: Los ntawm 2003 txog 2013, nws ua haujlwm ua tus kws muag tshuaj thiab yog tus thawj coj ntawm lub tsev muag tshuaj kiosk. Nws tau txais ntawv thiab cov kev sib txawv rau ntau xyoo ntawm consciousious kev ua haujlwm. Cov lus qhia txog cov ncauj lus kev kho mob tau raug luam tawm hauv cov ntawv tshaj tawm hauv zos (ntawv xov xwm) thiab ntawm ntau qhov chaw hauv Is Taws Nem.
Ncig ncig ua si hauv keeb kwm
Kev npaj siab los cawm tib neeg los ntawm "kev mob kis" zoo nkauj tau ua rau lub xyoo pua tag los.
Muaj tseeb, raws li kev txheeb cais, tom qab ntawd tsis muaj ib qho zoo tshaj plaws ntawm cov ntshav qab zib. Tus kab mob pib kis tau zoo thaum lub rhawv ntawm peb lub khw muag khoom pib tawg ntawm cov khoom lag luam tsis zoo, vim tias Soviet GOSTs tau tso tseg, thiab cov txuj ci tshiab tsis txwv cov chaw tsim khoom hauv kev sim rau peb kev noj qab haus huv.
Nkag siab tias qhov teebmeem tseem ceeb ntawm cov ntshav qab zib mellitus (DM) yog qhov kev ua txhaum ntawm cov khoom noj khoom haus metabolism, cov kws tshawb fawb tau sim los tsim cov tshuaj siv thoob ntiaj teb uas txwv kev siv cov carbohydrates, uas muab cov neeg laus nrog ib nrab hnub ntawm calories.
Yog lawm, hnub no tsis muaj leej twg ua tiav lub hom phiaj no yam tsis muaj roj zaub mov noj, tab sis ib qho kev txhawb ntxiv ntawm cov rog thiab carbohydrate metabolism yuav tsis ua mob rau cov neeg mob ntshav qab zib, tshwj xeeb tshaj yog txij li ob peb leeg muaj peev xwm ua raws li cov lus pom zoo ntawm tus kws kho mob endocrinologist.
Tom qab xam xyuas cov khoom noj txhua hnub ntawm cov tsis mob ntshav qab zib:
- Monosaccharides (nyob rau hauv daim ntawv ntawm fructose thiab qabzib) - 25 g,
- Kev Tsis Txaus Siab (sucrose) - 100g,
- Polysaccharides (xws li cov hmoov txhuv nplej siab) - 150g.
Nws tuaj yeem nkag siab tias kev thaiv cov suab thaj ntau dhau ntawm qhov zoo tshaj yog muab rau thawj theem ntawm cov metabolism, hauv txoj hnyuv, los ntawm qhov chaw uas lawv yuav tawm hauv lawv cov qauv qub.
Vim li cas thiaj mob siab rau cov hmoov txhuv nplej siab? Lub ntuj tso rau hauv α-amylase muaj amylose thiab amylopectin, thiab tuaj yeem muab cais ua kom tsis sib luag uas siv cov qaub ncaug thiab cov txiav ua kua, uas muaj cov enzymes α-amylase. Cov tshuaj cais ua rau cov piam thaj thiab fructose nyob rau hauv txoj hnyuv rau hauv qab ntawm of-glucosidases. Nws yog cov monosaccharides uas nkag rau hauv cov ntshav ntawm cov hnyuv.
Nws pom tseeb tias qhov kev txo qis hauv cov dej num ntawm lub cev thiab hnyuv yuav ua kom qeeb ntawm kev sib txig sib luag ntawm cov feem ntawm cov carbohydrates uas nkag mus rau hauv lub cev nrog zaub mov noj. Inhibitors ntawm saccharolytic enzymes, uas pom nyob hauv qee cov nroj tsuag (piv txwv, hauv stevia), yog yooj yim zom thiab tsis muab qhov tsis xav tau yam tsis zoo. Cov cim qhia tau pom nyob hauv buckwheat, rye, pob kws, legumes thiab txiv laum huab xeeb. Hmoov tsis zoo, lawv lub peev xwm tsis txaus rau glycemic tswj ntshav suav.
Microbial substrates tau pom tias muaj txiaj ntsig zoo dua, los ntawm cov tshuaj tiv thaiv kab mob nrog cov ntau ntawm cov cuam tshuam tau txais: cov protein, aminosaccharides, oligosaccharides, glycopolypeptides. Qhov tseem ceeb tshaj plaws ntawm olisaccharide yog Acarbosum, uas yog coj los ua ke los ntawm cov kab mob ua liaj ua teb. Los ntawm inhibiting plab hnyuv glucosidases, nws maj mam hloov ntawm cov hmoov txhuv nplej rau hauv qabzib.
Lwm cov kev coj mus muag ntawm nws tau raug tsim los ntawm ascarbose, tab sis lawv tsis muaj xws li cov txiaj ntsig multivariate.
Pharmacological tau
Tshuaj Ascarbose:
- Maj mam ua kom qhov nqus ntawm carbohydrates nyob rau hauv cov hnyuv,
- Txo postprandial (tom qab noj mov, "kaj siab" - "noj su") glycemia,
- Tiv thaiv hypoglycemia,
- Tsis suav qhov ua tau ntawm cov tshuaj insulin ntxiv.
Thaum noj cov khoom noj nrog qhov muaj kev xav zoo ntawm cov carbohydrates, qhov kev tiv thaiv hypoglycemic ntawm ascarbose yog tshwj xeeb tshaj yog pom.
Lub inhibitor pab tua cov rog, txo qis kev qab los noj mov thiab caloric kom tsawg ntawm kev noj zaub mov txhua hnub, thiab txo cov txheej ntawm visceral rog.
Kev quav rau cov rog, cov zaub mov ua kom muaj calorie ntau dhau los txo qhov kev ua haujlwm ntawm acarbose, txij li nws cov nyhuv yog tsom rau kev ua kom muaj cov carbohydrate, es tsis yog lipid metabolism.
Acarbose los ntawm cov tshuab ntawm kev nqis tes yog sib piv nrog cov muaj peev xwm ntawm fiber ntau, cov ntxhib ntxig ntawm cov uas ua rau tawv nqaij, tsis muaj rau kev zom los ntawm cov enzymes. Qhov txawv yog tias cov tshuaj inhibits lub peev xwm ntawm cov enzymes lawv tus kheej. Ib yam li cell insensitivity, carbohydrates ua "ua tsis tau" rau kev mob plab thiab tawm mus tsis hloov, nce cov quav ntau. Los ntawm qhov no nws ua raws tias lub peev xwm ntawm qhov inhibitor tuaj yeem ua kom zoo dua yog tias cov khoom siv nrog cov ntxhib ntxig siv tau nyob rau hauv parallel. Cov txheej txheem no muaj txiaj ntsig zoo hauv kev poob ceeb thawj.
Txawm hais tias nws cov khoom thaiv, tus inhibitor tsis cuam tshuam kev ua haujlwm ntawm lub plab, vim nws tsis cuam tshuam ncaj qha rau amylo-, proteo- thiab lipolytic kev ua haujlwm ntawm cov kua txiv.
Lub peev xwm ntawm cov tshuaj kuj yog nyob ntawm qhov koob tshuaj: nrog rau qhov nce ntawm qhov yuav tsum tau ua, cov cim ntshav hypoglycemic yog siab dua.
Tus mob ntshav qab zib noj acarbose thiab nws cov lus qhia tau pom qhov txiaj ntsig zoo hauv lwm qhov tseem ceeb:
- Txo cov roj triglycerol thiab cov roj (cholesterol) hauv cov ntshav,
- Txo cov lipoprotein lipase concentration hauv adipose cov ntaub so ntswg.
Yog tias ib qho inhibitor txhaj tshuaj ncaj qha mus rau hauv plab, nws txwv qhov kev ua haujlwm ntawm α-glucosidases. Carbohydrates yog zom ntev heev uas ib qho tseem ceeb ntawm lawv yog nthuav tsis hloov. Qhov no cuam tshuam rau cov lus qhia glucometer nyob hauv txoj kev nyiam tshaj plaws: txawm tias lawv nce ntxiv, lawv tsis tseem ceeb npaum li tsis muaj kev koom tes ntawm acarbose. Hais txog qhov ua tau zoo, nws tuaj yeem piv nrog nrov Metformin, uas yog contraindicated nyob rau hauv cov neeg mob ntshav qab zib nrog lub raum tsis ua haujlwm.
Acarbose tseem raug tshaj tawm rau thawj hom ntshav qab zib, vim nws txoj kev siv yuav txo qis ntxiv cov tshuaj insulin los ntawm ib nrab.
Cov tshuaj yuav pab ua kom glycemia li qub, tab sis kev noj haus yuav tsum tau kho kom haum rau nws, txij li thaum lub cev tsis muaj carbohydrate txaus ntshai tsuas yog txaus ntshai li qhov dhau mus.
Txawm hais tias nyob rau hauv kev mob siab, nrog decompensated mob ntshav qab zib, thaum insulin pab rau qab zib, tom qab ib qho kev kho mob ntawm acarbose, cov neeg mob ntshav qab zib tau sau tseg qhov txo qis hauv glucosuria (muaj cov piam thaj hauv cov zis).
Nws tsub kom cov tshuaj thiab cov kua nplaum ua kom siab, tab sis nws tsis yog 100% hloov rau cov tshuaj pib rau kev kho mob ntshav qab zib. Nws yog ntawv sau ua cov tshuaj ntxiv hauv kev kho mob sib xyaw. Piv txwv li, acarbose yuav txhim khu cov nyhuv ntawm sulfonylurea.
Cov tshuaj tseem tau qhia rau cov neeg ua xua uas tsis tuaj yeem tiv thaiv cov tshuaj insulin.
Nws yog ib qho tseem ceeb tias hom inhibitor no tsis muaj carcinogenic, embryotoxic thiab mutagenic muaj peev xwm.
Cov tshuaj yog neutralized nyob rau hauv plab zom mov, cov kab mob thiab cov enzymes pab tsim 13 hom tshuaj yeeb dej caw. Kev siv acarbose tsis tso tawm los ntawm txoj hnyuv hauv 96 teev.
Rau leej twg acarbose yog qhia thiab contraindicated
Ib qho inhibitor yog tshuaj rau:
- Mob ntshav qab zib Hom 2
- Cov roj metabolism cov metabolism
- Kev ntshaib plab metabolic,
- Mob Ntshav Qab Zib
- Kev pham
- Tsis muaj cov kua nplaum ua siab ntev,
- Ua txhaum ntawm kev yoo mov glycemia,
- Lactate thiab ntshav qab zib acidosis,
- Yam 1 ntshav qab zib.
Kev siv cov acarbose yog nyob rau hauv:
- Cov mob ua paug siab,
- Ketoacidosis,
Kev mob rwj thiab mob rau sab hauv plab hnyuv,- Kev mob caj dab
- Lub plab hnyuv tawm,
- Ntshav qab zib nephropathy,
- Cev xeeb tub, lactation,
- Cov me nyuam lub hnub nyoog.
Kev mob rwj thiab mob rau sab hauv plab hnyuv,Nrog kev ceev faj, acarbose thiab nws cov txiaj ntsig tau raug coj los tom qab kev raug mob, thaum lub sijhawm sib kis, txij li lub cev tsis muaj zog tsis muaj lub zog txaus kom rov ua haujlwm. Nrog lub cev tsis muaj qabzib lossis nws cov thaiv cov ntshav, hypoglycemia lossis acetonemic syndrome yog tau.
Ntawm cov kev mob tshwm sim muaj peev xwm ua tau:
- Plab mov
- Dyspeptic mob
- Ua rau muaj kev hloov pauv ntau ntxiv,
- Hematocrit txo
- Txo cov ntsiab lus ntawm cov vitamins thiab calcium nyob rau hauv cov hlab ntshav,
- Kev tawm pob, khaus, ua xua.
Kev quav tshuaj, mob plab thiab lwm yam teeb meem nrog lub plab thiab cov hnyuv tuaj yeem tshwm sim vim qhov ua kom qeeb ntawm kev nqus ntawm cov carbohydrates pab txhawb rau qhov tseeb tias qee qhov ntawm lawv txhawm rau hauv cov hnyuv thiab muaj ntev txaus ua ntej lawv nkag mus rau lub plab hnyuv loj. Cov khoom qab zib ntau ntau ua rau kev loj hlob ntawm cov kab mob uas ua rau lub cev muaj zog, mob plab, thiab lwm yam kev ua rau lub cev tsis ua hauj lwm.
Cov txiaj ntsig zoo sib xws yog pom nyob rau hauv cov khoom lag luam champagne, thaum cov kab mob carbohydrate-tiv cov kab mob kua txiv kab ntxwv suab thaj, tawm ntawm cov txiaj ntsig ntawm lawv lub neej ntawm thaj chaw artificially enclosed. Tej zaum, tau xav txog daim duab no, ntau tus neeg yuav tsum tso dej cawv.
Koj tuaj yeem tso tawm cov cua daj cua dub hauv cov hnyuv nrog metronidazole, uas tus kws kho mob tau sau tshuaj rau hauv parallel nrog acarbose. Kev ua kom muaj pa roj carbon thiab lwm yam sorbents siab zoo ntawm lub plab hnyuv microflora muaj qhov zoo li ntawd.
Txo cov txiaj ntsig ntawm acarbose txhawb kev tswj hwm:
- Estrogen
- Cov tshuaj hormones rau cov thyroid caj pas,
- Qhov ncauj txwv tsis pub muaj
- Calcium antagonists
- Phenothiazines thiab lwm yam tshuaj.
Acarbose - cov lus qhia rau kev siv
Raws li cov lus qhia, qhov muab tshuaj yog txiav txim siab raws li qhov hnyav ntawm tus neeg mob. Yog tias, piv txwv li, tus neeg mob ntshav qab zib muaj lub cev hnyav li 60 kg, qhov koob tshuaj 25-50 mg yog qhov txaus rau nws, nrog rau cov leeg hnyav dua, 100 mg 3 r / Hnub yog tau sau tseg.Qhov koob tshuaj ntawm lub inhibitor yuav tsum tau nce nyob rau hauv cov qib, kom lub cev tuaj yeem hloov kho, thiab cov kev phiv tshuaj tuaj yeem tshawb pom nyob rau lub sijhawm.
Noj tshuaj ua ntej noj mov los yog tib lub sijhawm. Nws yog ntxuav nrog kua, yog tias cov khoom noj txom ncauj yog tsis pub muaj carbohydrate, tsis muaj acarbose tsis tuaj yeem nqa.
Yog tias lub cev ua tsis zoo rau qhov kev xaiv, nws tuaj yeem nce ntxiv txog 600 mg / hnub. thiab ntau dua yog tias tso cai rau kev noj qab haus huv.
Inhibitor Analogs
Cov tshuaj sim nrov tshaj plaws rau acarbose yog Glucobay. Hypoglycemic tus neeg sawv cev yog tsim nyob hauv lub teb chaws Yelemees. Daim foos tso tawm - cov ntsiav tshuaj hnyav 50-100 mg, txhua pob muaj los ntawm 30 txog 100 daim.
Ntxiv rau cov tshuaj qub nyob hauv Suav teb thiab Tebchaws Europe, koj tuaj yeem yuav cov tshuaj uas tsis raug cai nrog lub npe lag luam Glucobay, hauv Asmeskas thiab Askiv - Precose, hauv Canada - Prandase. Rau cov neeg mob ntshav qab zib nrog cov zaub mov txawv zaub mov, cov tshuaj muaj txiaj ntsig zoo dua, thiab yog nrov heev hauv Suav teb, hauv Asmeskas - qhov tsis sib xws, nws txoj kev siv tsuas yog vim muaj raws plab thiab mob plab.
Xyuas txog acarbose
Hais txog cov tshuaj nrog acarbose Glucobay, kev txheeb xyuas ntawm kev poob phaus yog categorical. Cov tshuaj tsis yog tsim rau poob phaus, nws yog tshuaj rau cov neeg mob ntshav qab zib, feem ntau ntawm yam thib 2.
Txij li ntau ntawm peb muab lub zog los ntawm carbohydrates, ib qho kev cai lij choj tshuaj yeej pab tau rau cov neeg mob ntshav qab zib thiab cov uas poob ceeb thawj noj zaub mov kom zoo thiab tsis muaj kev phiv loj li cov tshuaj analogues, vim hais tias nws tuaj yeem noj kom muaj lub hom phiaj ua ntej ib qho ncuav mog qab zib los yog lwm qhov kev ntxias kom hnyav.
Pharmacological kev txiav txim
Nws muaj cov nyhuv hypoglycemic. Ib qho inhibitor uas inhibits qhov kev ua ntawm cov enzymes uas zom cov carbohydrates rau hauv cov suab thaj yooj yim. Qhov kev nqus ntawm cov carbohydrates nyob rau hauv txoj hnyuv qeeb, cov piam thaj yuav ruaj khov. Acarbose yog qhov tshwj xeeb tshaj yog rau cov neeg uas muaj kev tsis haum rau insulin lossis tsis haum rau kev kho mob metformin vim yog contraindications. Nws tsis muaj cov kabmob carcinogenic, nws muaj kev nyab xeeb rau lub cev dua li lwm yam tshuaj. Nws muaj feem cuam tshuam rau qhov tsis ua ntawm hypoglycemia tom qab noj mov thiab feem ntau txo qhov ntxim nyiam ntawm nws txoj kev txhim kho. Nws txo qis kev qab los noj mov, pab tswj lub cev nyhav, thiab tiv thaiv kev txhim kho ntawm cov tshuaj insulin ntxiv. Tshwj xeeb tshaj yog pom cov kev cuam tshuam ntawm acarbose thaum noj nrog cov khoom lag luam loj carb. Tsis tas li ntawd, kev saib xyuas ntawm cov roj cholesterol thiab triglycerides hauv cov ntshav txo qis, thiab lipoprotein lipase hauv cov ntaub so ntswg adipose.
Acarbose ua haujlwm li cas? Ib yam li fiber ntau, nws ua rau cov carbohydrates ua rau tsis pom kev rau cov kua zaub ua kua thiab qhov kev ua ntawm cov enzymes uas zom lawv rau monosaccharides. Raws li qhov tshwm sim, lawv tau tawm hauv cov quav, tab sis kev ua haujlwm ntawm lub plab tsis muaj kev ntxhov siab.
Cov Tshuaj Pharmacokinetics
Nws ua haujlwm hauv lub plab zom mov, yog nqus hauv daim ntawv ntawm metabolites. Qhov siab tshaj plaws yog pom tom qab ib teev. Nws yog cov roj hauv lub plab zom mov nws tus kheej, tawm hauv cov quav rau 96 teev, nrog rau los ntawm lub raum hauv daim ntawv ntawm metabolites (34%).
- Mob ntshav qab zib mellitus ntawm ob yam hauv kev sib xyaw ua ke,
- Mob Ntshav Qab Zib
- Kev pham yog kev phiv mob ntshav qab zib,
- Insulin tsis kam lossis kev fab tshuaj tiv thaiv.
Cov lus qhia rau siv (qauv thiab ntau npaum li cas)
Siv ib ntsiav tshuaj hais lus peb zaug ib hnub ua ntej yuav noj mov. Siv raws li qhov txuas rau hauv kev kho ua ke. Qhov ntau npaum li cas yog txiav txim los ntawm tus kws kho mob tuaj koom rau ntawm lub hauv paus ntawm kev tshuaj ntsuam. Thawj koob tshuaj yog 25 mg. Koj tuaj yeem maj mam nce ntxiv, tab sis tib lub sijhawm saib xyuas kev txhim kho kev phiv. Qhov ntau tshaj tawm yog 600 mg rau ib hnub. Lub sijhawm tiv thaiv yog tsawg kawg yog 6 lub hlis. Nws yog ib qho tseem ceeb kom ua raws li kev noj zaub mov noj.
Noj ntau dhau
Muaj mob plab, mob raws plab thiab pom tsis tau. Cov tsos mob tau raug tshem tawm tsis suav nrog cov khoom noj uas muaj cov khoom noj uas tau ua nrog carbohydrate los ntawm kev noj haus.
Nrog cov kev kho ua ke, kev mob ntshav qab zib yuav tshwm sim. Nws cov tsos mob: tsis muaj zog, pallor, lub cev tsis nco qab (txog qhov tsis nco qab lawm), kev tshaib plab, kiv taub hau, thiab lwm yam. Cov ntshav qab zib tsawg tuaj yeem tshem tawm ntawm nws tus kheej los ntawm kev noj zaub mov nrog carbohydrates. Ntsig thiab mob hnyav yog raug tshem tawm los ntawm kev txhaj tshuaj glucagon lossis dextrose tov. Hauv qhov no, yuav tsum tau txhaj tshuaj.
Yeeb tshuaj sib cuam tshuam
Txo cov teebmeem ntawm cov hnyuv adsorbents thiab enzymes.
Txhim kho qhov kev ua ntawm insulin, metformin, sulfonylurea, uas tsim kev hem thawj ntawm hypoglycemia.
Cov tshuaj nram qab no ua kom tsis muaj zog ntawm acarbose:
- thiazide diuretics,
- cov thyroid hormones,
- corticosteroids
- phenytoin
- phenothiazines,
- sympathomimetics
- estrogens, qhov ncauj txwv tsis pub muaj,
- calcium antagonists
- nicotinic acid
- isoniazid thiab lwm tus neeg sawv cev uas ua rau hyperglycemia.
Tsis muaj kev cuam tshuam tshwj xeeb thiab kev hloov pauv tau sau tseg. Feem ntau yooj yim zam rau.
Piv nrog analogues
Acarbose yog ib feem ntawm ntau cov tshuaj. Xav txog lawv cov khoom thiab cov ntsej muag hauv kev nthuav dav ntxiv.
Nws yog tsim los ntawm Bayer hauv lub teb chaws Yelemees hauv ob qhov tshuaj - 50 thiab 100 mg. Qhov no feem ntau tau sau tseg los ntawm kws kho mob. Nqe - 360-500 rubles, nyob ntawm seb muaj pes tsawg ntawm cov tshuaj. Glucobay tau tsim tsa zoo nyob rau hauv kev lag luam tshuaj, yog cov khoom siv rau cov neeg mob ntshav qab zib hauv kev mob ntshav qab zib ua ke nrog kev kho kev noj haus.
Ua los ntawm cov tuam txhab tsim khoom lag luam Turkish. Koob tshuaj 50 lossis 100 mg. Ib cov tshuaj zoo rau cov ntshav qab zib, muaj cov tshuaj xyuas zoo. Tsawg dua - nws nyuaj rau nkag hauv cov khw muag tshuaj Lavxias.
Muaj cov kab mob liraglutide, uas cuam tshuam cov kev ua haujlwm ntawm cov qe hlwb hauv cov txiav ua ke. Nws ua rau kev txo cov ntshav qab zib, me ntsis ua kom lub plab zom mov, uas yuav pab txo qhov hnyav. Cov ntawv thov zoo ib yam li acarbose. Muaj nyob hauv daim ntawv ntawm kev daws rau kev tswj hwm subcutaneous. Cov neeg tsim khoom - "Novo Nordisk", Denmark. Nqe - los ntawm 9000 rubles rau ob lub phwj daj. Muab thaum cov ntsiav tshuaj ua haujlwm tsis muaj txiaj ntsig. Cov neeg tuaj yeem siv tau rau kev sib xyaw ua ke nrog kev siv tshuaj insulin thiab lwm yam tshuaj hypoglycemic.
Metformin ntsiav tshuaj rau kev kho mob nyuaj. Los ntawm 500 rubles rau ib pob. Qhov ntau npaum li cas cov tshuaj sib txawv, kev kho mob yog tsim raws tus neeg xav tau. Nws yog tsim los ntawm lub tuam txhab Berlin-Chemie, lub teb chaws Yelemees. Nws cuam tshuam rau kev ua haujlwm ntawm beta hlwb hauv cov txiav, uas pab txo cov piam thaj hauv siab thiab ua kom lub cev hnyav dua. Cov yam ntxwv zoo sib xws, feem ntau hloov sib. Tsuas yog rho tawm ntawm Siofor yog tias metformin tsis haum rau txhua tus. Cov khoom sib tshuam zoo sib xws.
Kev siv cov tshuaj tiv thaiv kab mob ib qho twg yog nqa nrog kev tso cai los ntawm tus kws kho mob tuaj koom. Kev siv tus kheej yog txwv!
Feem ntau, kev kuaj ntshav qab zib txog cov tshuaj acarbose-based tshuaj yog qhov zoo. Qee tus neeg mob sau cia txhim kho kev mob tshwm sim hauv daim ntawv ntawm flatulence thiab lwm yam teeb meem digestive. Yuav luag txhua leej txhua tus tham txog qhov hnyav thiab cov ntshav qab zib kom txo qis.
Natalya: “Kuv twb tau noj Glucobay tau ib hlis lawm. Pib nrog 50 mg rau cov lus qhia los ntawm kws kho mob, tam sim no tau nce txog 100 mg. Ua ke nrog Novonorm. Tav su qab zib yav tsaus ntuj tawm hauv cov lus. Txawm hais tias kuv rhuav cov khoom noj, nws tsis yig. Tab sis tom qab ntawd muaj qhov phiv nyob rau hauv daim ntawv ntawm kev cuam tshuam ntawm cov hnyuv. Yog li, Kuv sim ua raws li tus kws kho mob cov lus qhia thiab ua raws noj zaub mov. "
Vladislav: “Tus kws kho mob tau sau ntawv“ Glucobai ”, uas muaj acarbose, tom qab kuv muaj qhov tsis haum rau metformin. Txog tus nqi, cov tshuaj no haum rau kuv, Kuv siv nws ntxiv cov tshuaj ntxiv. Cov kua nplaum tswj tau dhau los ua neeg zoo dua, zoo siab tias tsis muaj ntshav qab zib. Thaum pib kho mob muaj kev maj mam, tus kws kho mob tau muab tshuaj ntxiv, txhua yam rov zoo li qub. Kuv txaus siab rau cov nyhuv, thiab qhov hnyav tau nyob ruaj khov, uas kuv tau ua kom tiav rau lub sijhawm ntev. "
Oleg: “Kuv muaj ntshav qab zib hom 2. Muaj teeb meem nrog kev xaiv cov tshuaj ntxiv rau cov kev kawm tseem ceeb. Kuv twb sim ntau ntsiav tshuaj nrog metformin, tab sis lawv tsis haum rau kuv raws li kev ntsuas (mob raum). Tus kws kho mob qhia kom sim siv tshuaj raws li acarbose, uas yog, "Glucobay". Kuv tau noj nws rau ib lub hlis tam sim no, Kuv nyiam txhua yam. Tsis ntev los no, cov koob tshuaj tau nce siab txog 100 mg - tsis muaj txim. Lawv hais tias cov tshuaj ntawm metformin siv tau zoo dua, tab sis nws haum rau kuv. Yog li kuv qhia koj. ”
Larisa: “Kuv tau raug hais qhia tawm Glucobai. Tus kws kho mob tau qhuas nws, tau hais tias los ntawm nws tus kheej nws tsis ua rau nws lub qog ntshav qab zib. Kuv haus tshuaj txog 50 mg rau txog ib hlis. Kuv tau muaj teeb meem nrog cov hnyuv, uas kuv tsis tuaj yeem muab tshem tawm. Kuv yuav tsum tso cov tshuaj no thiab hloov mus rau cov tshuaj insulin. ”
Xaus
Acarbose-muaj cov tshuaj ib txwm pab cov neeg mob ntshav qab zib normalize cov piam thaj thiab qhov hnyav. Tshuaj muaj nyob hauv ntau kis, tab sis nco ntsoov sib xyaw nrog lwm tus kom tau txais txiaj ntsig zoo. Kev tshuaj xyuas ntawm cov neeg mob thiab cov kws kho mob feem ntau yog qhov zoo, feem ntau acarbose yog tsim nyog thiab muab qhov tshwm sim ntev.
Kuv puas yuav tsum haus tshuaj?
Thaum ib txwm muaj qabzib ntau, kev noj tshuaj pab tsis muaj qab hau. Txwv tsis pub, cov kev mob tshwm sim lossis cov teeb meem kev noj qab haus huv loj yuav tsum tau xav.
Ntshav qab zib kev noj zaub mov noj yog pom zoo rau haus nrog:
- 2 degrees ntawm tus kab mob,
- theem ntawm tus kab mob
- lwm txoj kev tawm los ua rau muaj cov ntshav qab zib hauv cov ntshav.
Vim li cas ntshav qab zib nce hnyav?
Kev pham muaj cai hauv 88% ntawm cov neeg mob ntshav qab zib.
Nquag, cov tshuaj insulin pab txo qis cov ntshav qabzib thiab thauj nws mus rau cov ntshav. Tawm tsam keeb kwm yav dhau los ntawm kev txhim kho ntshav qab zib mellitus, qhov txheej txheem no cuam tshuam.
Ua tib zoo mloog! Nyob rau theem 1 ntawm tus kabmob, muaj kev tiv thaiv insulin. Tus mob no yog pom los ntawm kev nce nyob hauv cov piam thaj thiab insulin ntau ib txhij.
Qhov no ua rau kev nce siab hauv kev sib txuas ntawm cov protein thiab cov rog thiab ua rau kev tawm tsam ntawm cov roj ntsha uas muaj roj ntau ntau. Tawm tsam no keeb kwm yav dhau los, kev rog dhau los.
Cov Tshuaj Kho Mob
Cov ntsiav tshuaj pom cov tshuaj uas pab kom yuag hauv cov ntshav qab zib hom 2.
Cov lus 1. Tawv muag tshuaj rau hom 2 ntshav qab zib mellitus:
| Tshuaj | Kev piav qhia |
 Metformin | Nws inhibits hepatic gluconeogenesis, thiab pab txhawm rau txo cov piam thaj nqus los ntawm txoj hnyuv. Tsis tas li, cov tshuaj cuam tshuam nrog kev nce qib ntawm cov piam thaj hauv kev siv. Ntaub so ntswg insulin hypersensitivity nce ntxiv. Lub cev hnyav yog stabilizing lossis txo qis. |
 Ntsia hauv qab | Qhov ncauj hypoglycemic tus neeg sawv cev. Tus neeg loj loj. Pab txo cov siab ua kom lub ntsej muag qab zib. Qhov no tshwm sim tawm tsam keeb kwm ntawm inhibition ntawm glycogenolysis thiab gluconeogenesis. Lub cev hnyav nce lossis txo qis dua. |
 Siofor | Tsis hais txog ntawm cov nyhuv ntawm cov ntshav qabzib hauv cov ntshav, cov tshuaj muaj txiaj ntsig ntawm lipid metabolism. Qhov no pab txo qis cov roj cholesterol tag nrho, nrog rau cov roj triglycerides thiab cov roj cholesterol tsawg. |
 Metfogamma | Cov tshuaj yog nrog los txo qis hauv LDL thiab triglycerides. Tus neeg mob lub cev nyhav hloov los sis maj mam rov zoo li qub. |
 Diaformin | Dimethylbiguanide. Concomitant nrog qhov txo qis hauv kev xav ntawm VLDL, LDL, triglycerides. Tus neeg mob lub cev hnyav hloov kho lossis txo qis. |
 Ascarbose | Alpha glucosidase inhibitor. Cov tshuaj yog tshuaj tawm tsam ntawm keeb kwm ntawm kev noj haus tsis zoo. Tsis tas li, cov tshuaj tuaj yeem ua kom qaug cawv thaum tab tom ua ke nrog kev kho mob. |
Lwm cov tshuaj slimming
Lub luag haujlwm tseem ceeb ntawm kev noj tshuaj rau qhov poob phaus yog kom ua tiav kev tswj cov metabolism hauv lub cev thiab nres qhov kev pheej hmoo ntawm kev nce ntxiv hauv cov ntshav qab zib.
Txog rau cov ntshav qab zib uas poob phaus, cov tshuaj nram qab no yog cov sau tseg:
- lojmuas
- sulfonylurea npaj
- glitazones
- Cov chaw kho mob
- alpha glucosidase inhibitors
- DPP-4 cov tshuaj tiv thaiv.
Txhua ntawm pab pawg ntawm cov tshuaj pab tswj qhov hnyav thiab pab txhawb nws txoj haujlwm txo qis.
Pom zoo Biguanides
Cov tshuaj hauv cov pab pawg no yog ua raws li tshuaj metmorphine. Biguanides - yog ib lub chaw muag tshuaj muaj npe, nrov hauv cov neeg mob ntshav qab zib. Cov tshuaj tau muab coj los kho txij li ntawm 50s ntawm xyoo pua 20th.
Rooj ntawv 2. Qhov zoo tshaj plaws biguanides:
| Tshuaj | Kev piav qhia |
 Avandamet | Tshuaj qhov ncauj hypoglycemic. Tawm tsam ntawm keeb kwm yav dhau los ntawm kev txo qis hauv cov ntshav hauv lub ntsej muag, ib qho kev txhim kho hauv kev tswj metabolic yog pom. Cov ntsiab lus ntawm cov roj (cholesterol) tag nrho, TG thiab LDL kuj txo. |
 Bagomet | Cov tshuaj maj mam txo qis qis siab rau hepatic glucogenesis. Kev noj qabzib hauv lub ntsej muag yog txo. Kev siv cov rog ntawm qabzib ntau zuj zus. Lub cev hnyav los tswj lub siab sib luag los yog tsawg zuj zus lawm. |
 Metformin-Akrikhin | Cov tshuaj inhibits gluconeogenesis, tiv thaiv "kev yug menyuam" ntawm cov roj ntsha dawb thiab cov roj oxidation. Lub cev hnyav thawj zaug pib ruaj khov, tom qab ntawd maj mam poob. |
Ua tib zoo mloog! Cov tshuaj ntawm cov pab pawg no ua rau muaj qhov tshwm sim ntawm kev phiv. Yog li, lawv tau raug xaiv tsa hauv qee kis tshwj xeeb xwb.
Qhov zoo tshaj plaws sulfonylureas
Lub hom phiaj tseem ceeb ntawm cov tshuaj ntawm cov pab pawg no yog kom txhawb nqa pancreatic beta hlwb los tsim cov tshuaj insulin. Cov tshuaj tau sau tseg thaum cov tsos mob ua kom qaug zog tuaj.
Cov lus 3. Kev siv sulfonylurea npaj:
| Cov tshuaj noj | Dab tsi yog nws? |
 Lawj xeeb | Nws yog sulfonylurea derivative ntawm 2 tiam. Kev siv ntawm cov tshuaj pab txo lub sijhawm sib txawv txij li lub sijhawm noj mov kom pib lub sij hawm ntawm insulin secretion. Nws ua rau kev kho rov qab los ntawm qhov ntxov ntawm insulin secretion, txo qis ncov tom qab ntawm hyperglycemia. Tsis tas li, cov tshuaj pab ua rau txo cov neeg dawb. |
 Amaril | Nws yog 3-tiam sulfonylurea derivative. Nws muaj cov nyhuv insulinomimetic. Ua rau kev tswj hwm kev tsim nyog ntawm insulin secretion. Qhov no yog vim muaj kev sib xyaw ntawm ATP-nkag siab poov tshuaj raws nrog beta-cell daim nyias nyias. |
 Hauv daim duab Glimepiride | Pab pab txhawb kev ua kom tso pa tawm thiab tso tawm cov insulin los ntawm pancreatic beta cells. Nws kuj tseem muaj qhov ua haujlwm ntxiv. Pom zoo rau cov ntshav qab zib hom 2. |
 Diameride (Dimexide) | Tiv thaiv platelet aggregation. Qhov no yog vim muaj kev txo qis hauv kev hloov pauv ntawm arachidonic acid rau thromboxane A2. Qhov ua rau anti-atherogenic ntawm cov tshuaj yog vim muaj ib qho kev poob qis hauv cov ntsiab lus ntawm malondialdehyde hauv cov ntshav. |
 Glemaz | Txhawb nqa qhov tso tawm ntawm insulin, muaj kev ua haujlwm ntxiv. Pom zoo rau cov ntshav qab zib hom 2. |
Cov tshuaj ntawm cov pab pawg no tseem raug kho hauv qee kis tshwj xeeb. Qhov no yog vim qhov kev pheej hmoo ntawm hypoglycemia. Tus nqi ntawm cov tshuaj nws txawv ntawm 147 txog 463 rubles.
Pom zoo Glitazones
Cov tshuaj uas tsis muaj piam thaj uas yog tshuaj kom txo tau cov tshuaj insulin.
Rooj 4. Cov glitazones zoo tshaj:
| Tshuaj | Kev piav qhia |
 Avandaglim | Pab txhawm rau txhim kho kev tso tawm ntawm insulin los ntawm kev noj qab haus huv pancreatic beta hlwb. Nws yog tshuaj kho rau kev sib txuam, rau hom ntshav qab zib hom 2. Raws li qhov tshwm sim, kev txhim kho synergistic hauv glycemic tswj tau pom. |
 Pioglar | Nws yog qhov xaiv tau zoo gamma receptor agonist. Lawv kev ua kom yog vim yog tus proliferator peroxisome. Insulin tsis kam rau hauv cov hlab pas thiab daim siab ua haujlwm yog qhov ib txwm. Nrog DM-2, qhov kev txo qis ntawm qhov kev tso tawm ntawm TG thiab qhov nce ntawm qib HDL raug pom. |
 Diab ntau | Pab txo cov tshuaj tiv thaiv insulin hauv cov nqaij nruab nrog cev thiab hauv lub siab. Cov tshuaj tsis tau sau rau tshuaj insulin-tiv thaiv ntshav qab zib hom 1. |
 Astrozone | Concomitant nrog qhov txo qis hauv insulin tsis kam. Qhov no yog vim qhov haujlwm ntawm pioglitazone. Tib lub sijhawm, ntshav qabzib txo qis. Qib ntshav insulin kuj raug txo kom tsawg. |
 Diaglitazone | Cov tshuaj pab txo qis cov ntsiab lus ntawm triglycerides thiab nce cov ntsiab lus ntawm cov lipoproteins ntau ntom, nrog rau cov roj (cholesterol). Kev tsim cov tshuaj insulin tsis nthuav tawm. |
Ua tib zoo mloog! Ua ke nrog nrog Metformin, cov tshuaj hauv pab pawg no pab kom poob phaus sai dua.
Tshuaj Kho Kom Zoo Tshaj
Cov no yog cov kev txhawb zog lub zog insulin luv luv. Muab rau tswj qib qab zib tom qab noj mov.Qhov hnyav yog cuam tshuam nkaus xwb yog tias kho nrog monotherapy.
Rooj 5. Kev siv ntawm av nplaum:
| Tshuaj | Dab tsi yog nws? |
 Novonorm | Pab thaiv ATP-tubules nyob rau hauv daim nyias nyias ntawm cov beta hlwb. Tsis pub dhau ib nrab ib teev tom qab noj cov tshuaj, ib qho tshuaj insulinotropic tau pom. Qhov no pab txo cov ntshav cov ntshav qabzib. |
 Inswada | Nws yog lub qhov ncauj ua kom ceev ceev ntawm cov kua dej tso pa tawm. Pab txo cov ntshav qabzib feem ntau. Qhov no yog vim muaj kev ua kom muaj zog ntawm insulin secretion los ntawm txoj cai txiav. Tsis tas li, cov tshuaj nrog rau kev kaw ntawm ATP-tubules cov poov tshuaj hauv daim nyias nyias ntawm cov qe ntshav. Rau qhov no, cov protein tshwj xeeb yog siv. Raws li qhov tshwm sim, calcium channels qhib. |
 Starlix | Nws yog ib qho muab sib txuas ntawm cov amino acid phenylalanine. Txhawb nqa rov ua kom zoo thaum ntxov ua kom muaj kua dej. Tawm tsam ntawm cov keeb kwm yav dhau los no, qhov kev ncua siab tom qab ntawm cov piam thaj hauv cov ntshav txo qis. Cov ntsiab lus ntawm glycated hemoglobin kuj tseem li qub. |
Pom zoo Alpha Glucosidase Inhibitors
Tshuaj pab ua rau kom lub plab zom cov zaub mov kom qis. Qhov no ua rau qhov ua tsis tau ntawm kev nce siab ntxiv hauv cov piam thaj hauv cov ntshav. Tawm tsam keeb kwm ntawm kev tswj hwm, glycated hemoglobin yog li qub, insulin tsis kam poob qis.
Cov lus 6. Kev siv alpha-glucosidase inhibitors:
| Cov tshuaj noj | Kev piav qhia | ||||||||||
 Acarbose | Oligosaccharide muab tau los ntawm cov kab mob microinism Actinoplanes utahensis. Cov tshuaj txhawb nqa qhov rhuav tshem ntawm di-tri - thiab oligosaccharides hauv lumen ntawm txoj hnyuv me. Kev nqus tau tsawg, cov ntaub ntawv lo nyob hauv txoj hnyuv. Tsis tas li, cov tshuaj cuam tshuam nrog txo qis hauv postprandial hyperglycemia. | ||||||||||
 Glucobay | Pseudotetrasaccharide ntawm keeb kwm microbial. Nws inhibits hnyuv enzyme alpha glucosidase, uas tawg rau polydi thiab oligosaccharides. | ||||||||||
 Miglitol | Pab ua kom cov ntshav khov thawm ntws rau hauv cov ntshav thiab txo cov ntshav qabzib tom qab noj mov. | ||||||||||
 Diastabol | Nws nrog rau kev txo qis hauv hyperglycemia tom qab noj mov, smooths 24-teev nyob rau hauv qab zib concentration profile. Pab txo qis txhawm rau cov ntshav txhauv. Qhov concentration ntawm glycosylated hemoglobin yog txo qis. Cov tshuaj tsis cuam tshuam rau kev nqus ntawm kev noj zaub mov qabzib. Qhov zoo tshaj plaws inhibitors ntawm enzyme DPP-4Cov tshuaj hauv cov pab pawg no muaj cov nyhuv ntawm cov tshuaj hormones ntawm lub plab zom mov. Lawv raug xaj tau los tswj lub cev qhov hnyav. Cov Lus 7. Kev siv lub zog ntawm cov tshuaj tiv thaiv ntawm cov enzyme DPP-4:
|
Sitagliptin
Vildagliptin
Linagliptin
Saxagliptin
Chromium rov qab insulin rhiab heev rau cov hlwb
