Cov tshuaj Altar: cov lus qhia rau kev siv

Tsis muaj teeb meem ntau npaum li cas peb xav kom cog qoob loo zoo tsis muaj ib qho kev siv tshuaj lom neeg, alas, qhov no yog nyob deb ntawm qhov ib txwm ua tau.

Feem ntau nrog cov kab thiab kab mob ntawm cov qoob loo koj yuav tsum tawm tsam nrog tshuaj tua kab - tshwj xeeb tshuaj lom neeg, siv los tua cov kab, lawv cov kab menyuam, lawv cov qe, thiab nematodes thiab zuam.

Tshuaj tua kab "Alatar": cov ntaub ntawv xov xwm

Txhais tau tias "Alatar" belongs rau cov pab pawg ntawm cov tshuaj nrog kev sib cuag-plab hnyuv nkaus. Nws yog qhov zoo tshaj plaws rau kev tua kab tsuag ntawm lub vaj thiab zaub vaj, txhim khu kev ntseeg tiv thaiv lub tsev kawm ntawv ntawm tus kab mob. Cov tshuaj yuav pab tiv thaiv aphids, nplooj npauj, npauj, paj paj, zaub qhwv npauj, tinnitsa, raspberry thiab pos nphuab weevil thiab lwm tus qhua tsis tau caw.

Cov tshuaj tua kab uas tau piav qhia tau muag nyob rau hauv daim ntawv ntawm kev muaj zog emulsion muab tso rau hauv 5 ml ampoules lossis hauv 25 ml vials. Txhawm rau npaj cov tshuaj ua haujlwm, cov ntsiab lus ntawm ampoule yog diluted nyob rau hauv cov dej me me (li 2-3 l), thiab tom qab ntawd cov kua dej ntxiv rau kom txog thaum cov cai no mus txog. Txhua kab lis kev cai xav tau nws tus kheej ntawm Alatar, raws li tau piav qhia hauv cov lus qhia rau nws siv. Xijpeem tag nrho cov tshuaj ntim yuav tsum yog 10 l (txoj kev daws teeb meem yuav tsum muab sib xyaw).

Nquag khoom xyaw thiab cov txheej txheem ntawm kev nqis tes ua

Yog tias koj ntseeg tias qhov kev txheeb xyuas ntawm cov neeg nyob hauv lub caij ntuj sov, tom qab ntawd “Alatar” lav ris nrog cov haujlwm ntau dua li lwm cov zoo sib xws. Nws ua tau kom ua tiav cov txiaj ntsig zoo sib xws vim muaj ob qhov muaj zog hauv nws cov tshuaj: cypermethrin thiab malathion. Malathion (lossis karbofos) belongs rau chav kawm ntawm organophosphorus tebchaw nrog kev ua kom dav. "Alatar" zoo kawg nkaus tiv thaiv cov nroj tsuag ntawm aphids (uas yog, nws feem ntau tswj hwm lub xaib), thiab tseem tiv thaiv qhov kev tawm tsam loj ntawm cov kab thiab zuam.

Txoj haujlwm thib ob yog kev tiv tauj-plab hnyuv tshuaj tua kab, uas yog tus yam ntxwv ua haujlwm siab thiab ua rau tuag tes tuag taw ntawm cov hlab hlwb ntawm cov kab mob, tsis hais tus laus thiab tus menyuam yaus. Tsis tas li ntawd, Alatar tseem suav nrog cov nplaum tshwj xeeb uas ua tau haujlwm tshwj xeeb - nws tiv thaiv kev daws los ntawm kev dov tawm ntawm nplooj los yog ntxuav nws los ntawm nag (Cov ntaub ntawv hais txog qhov no tuaj yeem pom nyob rau hauv cov lus qhia rau kev siv, uas txuas nrog rau cov tshuaj, lossis hauv cov lus qhia los ntawm lub network).

Cov lus qhia rau kev siv tshuaj "Alatar" rau kev cog qoob loo

Raws li peb tau pom ua ntej, kev sib txawv yuav tsum muaj qhov sib txawv ntawm cov tshuaj tau piav qhia, yog li ua ntej pib nrog cov kev nrawm ntawm cov kua ua haujlwm, koj yuav tsum txiav txim siab qhov ntau npaum li cas. Hais txog Alatar cov khoom lag luam thiab nws cov lus qhia rau kev siv, peb yuav tsis tsim ib cov ntxhuav, tab sis tsuas yog piav qhia ntau npaum li cas rau cov tshuaj feem ntau cov cog niaj hnub no.

Zaub pob, qos yaj ywm, dos, carrots, txiv pos nphuab

Zaub pob yog cov tshuaj tsuag nrog Alatar nkaus xwb thaum lub caij nquag nquag. Txhawm rau npaj cov tshuaj ua haujlwm, cov ntsiab lus ntawm ampoule (5 ml) yog diluted hauv 4 liv dej, tom qab uas cov nroj tsuag tau txau nrog cov txiaj ntsig. Kev noj haus ntawm cov tshuaj nyob rau hauv cov ntaub ntawv no yog 4 liv ib 100 m². Ua cov zaub pob yog siv los tshem tawm cov teeb meem ntawm cov butter dawb, cov npauj cij, cov quav txaij, pas nrig, nplooj tsawb.

Txau nrog cov qos yaj ywm npaj yuav tsum tau nqa tawm tsuas yog nrog qhov loj ntawm cov kab tsuag. Raws li hauv rooj plaub dhau los, rau 100 m² koj yuav xav tau 4 litres ntawm cov kua dej ua haujlwm, thiab lub sij hawm rau phau ntawv ua haujlwm yog 10 hnub. Cov tshuaj tua kab yog siv rau hauv kev tawm tsam Colorado qos moth npauj kab thiab tus nyuj.

Ib txoj kev daws teeb meem tseem tau npaj raws li cov txheej txheem zoo ib yam rau txau cov dos, carrots thiab txiv pos nphuab: 5 ml ntawm cov tshuaj yuav tsum tau diluted hauv 4 liv dej. Hauv cov xwm txheej no, Alatar cov tshuaj tua kab (raws li cov lus qhia) yuav pab kom tshem tau carrot nplooj flax, dos ya thiab tiv thaiv txiv pos nphuab ntawm raspberry-strawberry txiv hmab txiv ntoo-kev coj tus kheej.

Txau lub vaj txiv hmab txiv ntoo hauv lub vaj, thiab nrog nws pears thiab quinces, tau ua thaum lub caij nquag cog qoob loo ntawm cov ntoo, tom qab diluting 5 ml ntawm cov tshuaj hauv 10 l dej. Qhov nruab nrab, kwv yees li 5 litres ntawm cov dej num ua hauj lwm tau siv rau ib tsob ntoo: 3 l - rau cov qauv me thiab 6-8 l - rau kev cog neeg laus. Cov yeeb ncuab tshaj plaws ntawm cov kua ntoo yog npauj, paj kab, aphids, npauj, npauj, sawflies, cov nplooj npog, thiab Alatar copes nrog lawv zoo kawg nkaus.

Txhawm rau kho currants thiab gooseberries, 5 ml ntawm cov tshuaj yuav tsum tau diluted hauv 5 l dej.

Kev ntws tawm ntawm cov kua dej ua haujlwm yog txog li 1 liter rau ib lub hav txwv yeem, uas yuav pab tshem tawm cov aphids.

Ua cov ntoo ntoo, thaj av thiab cov paj ntoo

Cov tshuaj Alatar kuj tseem pab kom tshem tau cov kab tsuag thaum loj hlob paj ntoo thiab ntoo hauv thaj chaw nws nyob. Xws li cov nroj tsuag xav tau kev saib xyuas tshwj xeeb, yog li ntawd lawv tau muab txau peb zaug: ua ntej thiab tom qab pib tawg paj, nrog rau thaum lub caij cog qoob loo. Kev noj haus ntawm cov tshuaj tiav yog 1.5 liv ib 10 m², thiab tshuaj txau ua kom zoo tshaj plaws thaum sawv ntxov lossis thaum yav tsaus ntuj (tom qab hnub poob), hauv huab cua txias thiab qhuav. Txhua nplooj ntawm cov nroj tsuag yuav tsum tau moistened tusyees, 4-6 teev ua ntej cov dej nag uas tsis muaj.

Qhov kub zoo rau txheej txheem yog suav tias yog + 12 ... + 25 ° °. “Alatar” rau kab tswj tiv thaiv kab ntoo zoo nkauj los ntawm nqus thiab nplooj ntoos-noj kab tsuag, dipterans thiab lub cev tsis xwm yeem (qhov no tseem muaj qhia nyob hauv cov lus qhia). Txhawm rau kho cov nroj tsuag zoo li no, 5 ml ntawm tshuaj (ib qho ampoule) yog diluted hauv 3.5 l dej.

"Alatar" kuj tseem tsim nyog rau kev kho cov ntoo hauv tsev, thiab txawm hais tias qhov tshuaj pom zoo rau cov paj hauv cov lauj kaub tsis yog qhia hauv cov lus qhia rau kev siv, lawv tuaj yeem muab tshuaj tsuag nrog cov qub uas koj siv los ua cov ntoo cog kom zoo nkauj.

Cov txiaj ntsig ntawm kev siv tshuaj "Alatar" los tswj cov kab

Txhua yam tshuaj lom neeg siv niaj hnub no muaj qee yam muaj txiaj ntsig zoo, tab sis raws li rau Alatara, hauv kev sib piv nrog cov neeg sib tw Nws muaj cov zoo li nram no:

• Nws muaj cov hauj lwm siab, uas yog kev lom zem ntau vim muaj ob lub zog muaj zog uas ua rau kom muaj kev puas tsuaj tiav ntawm txawm tias feem ntau tiv taus tshuaj tua kab,
• muaj cov kua nplaum tshwj xeeb uas tiv thaiv kev ntxuav tawm los yog kev raug mob tshem tawm tshuaj los ntawm nplooj ntawm cov nroj tsuag kho,
• Nws muaj lub sijhawm ntev ntawm kev siv, uas tau piav qhia los ntawm kev siv qis ntawm cov khoom lag luam (feem ntau, 10 ml kua yog txaus rau ib qho ampoule nrog ntim ntawm 5 ml).

Kev ntsuas kev nyab xeeb thaum ua haujlwm nrog cov tshuaj

Thaum ua haujlwm nrog txhua yam tshuaj, yuav tsum muaj kev ceev faj txog kev nyab xeeb. Ua ntej, nws yog qhov zoo dua rau ua cov txheej txheem hauv huab cua txias lossis kom cua me ntsis los ntawm koj. Thib ob, nco ntsoov npog nrog cov ris tsho txhua qhov chaw ntawm lub cev (looj hnab looj tes thiab lub kaus mom). Tsom iav thiab lub ntsuas pa yuav tsis ua kom muaj kua, vim tias koj tuaj yeem tiv thaiv koj lub qhov muag, lub plab zom mov thiab lub plab ua pa. Tsis tas li ntawd nco ntsoov xyuas kom meej tias thaum ua qhov txheej txheem tsis muaj neeg lossis tsiaj nyob ze.

Tsis txhob haus luam yeeb lossis noj thaum txau khoom. Yog tias, txawm hais tias tag nrho cov kev ceev faj, cov tshuaj tseem yuav nkag mus rau hauv lub qhov muag lossis ntawm daim tawv nqaij, lawv yuav tsum tau ntxuav nrog cov dej ntws huv. Yog hais tias qhov muaj pes tsawg leeg nkag mus rau hauv lub cev los ntawm lub qhov ncauj, ua kom huv huv nws yaug nrog dej, haus ob peb khob dej sov lossis haus mis thiab nqa cov pa hluav taws ntawm tus nqi ntawm 1 g rau 1 kg ntawm lub cev hnyav. Tom qab qhov no, los ntawm kev khaus lub phab ntsa pharyngeal tom qab, ntuav yog tsim nyog.

Tom qab ua tiav txoj haujlwm, ntxuav koj txhais tes kom sai nrog xab npum, thiab yog tias ua tau nws zoo dua yog da dej.

Cia rau cov neeg mob thiab txee lub neej ntawm Alatara

"Alatar" raws li tshuaj rau aphids, kab, zuam thiab lwm yam kab yog muab rau hauv daim ntawv ntawm ampoules (5 ml) lossis 25 ml vials. Nyob rau hauv txhua rooj plaub, lub txee lub neej ntawm cov muaj pes tsawg leeg yuav tsum tsis pub ntau tshaj ob xyoos. Txhua lub sijhawm no, pob nrog rau cov tshuaj yuav tsum nyob hauv chav qhuav thiab tsaus ntuj nrog qhov ntsuas kub ntawm -5 ° С ... + 25 ° С, cais los ntawm cov khoom lag luam thiab tshuaj. Ib qho ntxiv, tsis pub menyuam yaus lossis tsiaj nyob hauv yuav tsum muaj kev nkag tau rau nws. Tsis tas li, cov khoom lag luam yuav tsum muaj kev tiv thaiv los ntawm hluav taws.

Yog lawm, ua haujlwm hauv lub vaj thiab vaj hauv tsev tsis tuaj yeem hu ua ib txoj haujlwm yooj yim, ntxiv rau, qhov kawg tshwm sim tsis tas li ntawm kev mob siab. Ntxiv rau tib neeg yam, huab cua thiab huab cua puag ua si lub luag haujlwm tseem ceeb, tab sis qhov no tsis txhais tau tias koj yuav tsum tso nws. Muaj kev ua tiav cov nroj tsuag nrog Alatar koj yuav pab lawv daws ib qho teeb meem loj tshaj plaws - kab tsuag, thiab cov qoob loo zoo tuaj yeem tiv taus cua txias lossis dej nag.

Txoj kev ntawm daim ntawv thov

Ib qho kev nce ntxiv hauv cov koob tshuaj tsis ua rau muaj kev nce ntxiv hauv kev ua kom zoo nkauj, tab sis, nyob rau hauv cov chaw raug rho tawm qhov siab tshaj plaws txhua hnub tuaj yeem nce ntxiv txog 6 mg. Tag nrho cov tshuaj txhua hnub yog noj rau ib lub sijhawm thaum noj mov (thawj). Cov ntsiav tshuaj yuav tsum tau muab ntxuav nrog nrog cov kua txaus. Yog tias 1 mg ntawm glimepiride ua rau kev txhim kho hypoglycemia, feem ntau yuav, rau cov neeg mob hauv kev kho mob ntshav qab zib, kev noj zaub mov txaus yuav txaus. Thaum kho, nws yuav tsim nyog los txo cov tshuaj glimepiride, uas cuam tshuam nrog kev txhim kho cov metabolism thiab nce cov nqaij mos rhiab ua rau cov tshuaj insulin.
Cov tshuaj Altar tuaj yeem siv tau ob qho tib si li monotherapy, thiab ua ke nrog insulin lossis metformin.

Sab sij huam

Phiv los ntawm kev siv cov tshuaj Thaj neeb tuaj yeem tshwm sim los ntawm cov kab mob ncig: tsis tshua muaj - leukopenia, thrombocytopenia, granulocytopenia, agranulocytosis, hemolytic anemia, pancytopenia. Txhua yam mob feem ntau yuav thim rov qab.
Ntawm ib feem ntawm kev tiv thaiv kab mob hauv lub cev: nyob rau hauv tus kheej sib cais, kev tsis haum lub ntsej muag yog pom, tshwm sim los ntawm txoj hlab ntshav hypotension, txhawm chim, anaphylactic poob siab. Tsis tshua muaj leej twg muaj kev tsis haum tshuaj vasculitis, tuaj yeem sau tshuaj tiv thaiv khaub thuas nrog sulfonamides, sulfonylurea derivatives lossis lwm yam tshuaj.
Ntawm ib feem ntawm cov metabolism hauv lub ntsiab: tsis tshua muaj ntshav qab zib.
Los ntawm ob sab ntawm lub zeem muag pom tau hais tias: thaum pib kho mob, qhov cuam tshuam rov qab pom tau vim qhov hloov pauv ntawm cov ntshav hauv cov piam thaj yuav raug kaw.
Los ntawm lub plab zom mov: ntuav, xeev siab, raws plab, mob plab, zoo nkaus hauv lub plab tag nrho. Cov tsos mob no yuav tsum tsis ua txuas ntxiv ntawm cov tshuaj.
Los ntawm cov kab mob hepatobiliary: nce kev ua haujlwm ntawm daim siab enzymes. Tsis tshua muaj - jaundice, cholestasis, mob siab ua haujlwm, mob siab.
Los ntawm daim tawv nqaij: khaus, urticaria, exanthema, tsis tshua muaj tshwm sim - photosensitivity.
Kev cuam tshuam sov hauv tshuab hluav taws xob: tsawg kawg - hyponatremia.

Cov Yuav Tsum Tau Ua

Cov tshuaj tiv thaiv kom zoo rau kev siv tshuaj Thaj neeb yog: ketoacidosis, hom I mob ntshav qab zib mellitus, mob ntshav qab zib tsis tsaug zog, kab mob siab thiab mob raum, mob siab rau glimepiride thiab lwm yam sulfonylureas. Hypersensitivity rau ntu pab ntawm lub Thaj.

Kev cuam tshuam nrog lwm yam tshuaj

Thaum noj cov tshuaj Thaj neeb nrog rau lwm yam tshuaj, qhov ua kom tsis muaj zog los yog qhov tsis txaus ntseeg nyob hauv nws lub cev hypoglycemic yuav tau sau tseg. Glimepiride muab nws cov nyhuv los ntawm cytochrome P450 2C9. Nws yog qhov ua pov thawj tias kev siv ua ke ntawm kev ua kom zoo (piv txwv, rifampicin) thiab cytochrome P450 2C9 inhibitors (fluconazole) cuam tshuam rau cov metabolism ntawm glimepiride.
Kev nce hauv hypoglycemic lub zog ntawm cov tshuaj Altar tau pom thaum nws siv ib txhij nrog phenylbutazone, azapropazone, oxyphenbutazone, sulfinpyrazone, tshuaj tiv thaiv kab mob hauv lub qhov ncauj, insulin, sulfanilamides nrog kev siv lub sijhawm ntev, tetracyclines, salicylates thiab PASA, tshuaj txiv neej, tshuaj anabolic thiab cov tshuaj anabolic. , chloramphenicol, probenicide, coumarin anticoagulants, miconazole, fenflura mees, pentoxifylline (per os hauv qib siab), fibrates, tritokvalin, ACE inhibitors, fluoxetine, allopurinol, sympatholytic, cyclophosphamide, trophosphamide, ifosfamide, fluconazole. Kev txo qis hauv cov khoom hauv hypoglycemic ntawm Altar yog pom thaum nws siv ib txhij nrog estrogens thiab progestogens, saluretics, thiazide diuretics, cov neeg sawv cev uas txhawb cov kev ua haujlwm ntawm cov thyroid caj pas, GCS, phenothiazine thiab chlorpromazine derivatives, epinephrine thiab sympathomimetics, nicotinic acid thiab nws cov thiv thivas , finitoin, diazoxide, glucagon, barbiturates, rifampicin, acetazolamide. Β-adrenergic blockers thiab H2-receptor blockers, reserpine thiab clonidine tuaj yeem yog qhov tsis muaj zog lossis txhim kho hypoglycemic lub zog ntawm cov tshuaj Altar. Nyob hauv kev cuam tshuam ntawm sympatholytics xws li reserpine, guanethidine, clonidine, thiab β-adrenergic blockers, cov nyhuv ntawm kev txiav txim siab adrenergic ntawm kev txo qis hauv qabzib yuav ua kom tsis muaj zog lossis tsis tuaj. Glimepiride ua kom tsis muaj zog lossis txhim kho qhov cuam tshuam ntawm coumarin derivatives.

Noj ntau dhau

Tseem muaj tshee, hypertonicity, mydriasis, pw tsaug zog, endocrine kev mob hlwb (kev coj tus cwj pwm tsis txaus ntseeg - piv txwv li, txhoj puab heev, tsis xis nyob, tsis zoo ntawm kev saib xyuas, kev nyuaj siab, tsis meej pem), tsis muaj kev ntseeg siab ntawm kev txav mus los, kev pib kho qhov tsis zoo (kev coj ntawm lub cev, kev sib ntaus, kev sib kis). (hemiplegia, diplopia, aphasia), ua kom qaug dab peg, tsaug zog, qaug zog, tsis nco qab, ua tsis tau pa ntawm txoj cai ntawm lub ntsws thiab cov leeg ntshav.
Kev Kho Mob. Ua ntej tshaj plaws, kev ntsuas tau txhawm rau tshem tawm cov tshuaj coj los ntawm lub cev: ntxias cov ntuav, pais plab lav, siv cov sodium sulfate thiab cov pa roj carbon activated. Kev mob ntshav qab zib tsis muaj qhov tsis nco qab ua rau lub siab tuaj yeem raug tshem tawm los ntawm kev tswj hwm ntawm 20 g ntawm cov piam thaj, piam thaj lossis kua txiv. Hauv cov ntawv hnyav ntawm hypoglycemia, nrog rau kev tsis nco qab, kev teeb tsa thaum muaj xwm ceev ntawm txoj hlab ntshav hluav taws xob yog qhov tsim nyog, tom qab ntawd muab 20% cov kua nplaum (40-100 ml) raug tswj hwm. Yog tias tus ntsuas catheter tsis raug ntsia, 1-2 ml ntawm glucagon tuaj yeem muab tshuaj subcutaneously lossis intramuscularly. Tom qab ua tiav rov qab ntawm kev nco qab rau kev tiv thaiv kom rov huam, nws yog qhov yuav tsum tau noj 20-30 g ntawm carbohydrates txhua 2-3 teev sab hauv rau 24-48 teev. Tom qab qhov kawg ntawm lub xeev hypoglycemic, qabzib tau saib xyuas rau 48 teev. Nyob rau hauv rooj plaub uas tsis nco qab lawm tseem muaj kev cuam tshuam ntxiv, ntxiv 5-10% kua nplaum nyob hauv. Yog hais tias cov duab hauv chaw kho mob tsis hloov, koj yuav tsum xav txog lwm qhov, tsis cuam tshuam nrog kev mob ntshav qab zib, ua rau tsis nco qab. Nyob rau hauv tib si, nws yog ib qhov tsim nyog los ua kev kho mob rau cerebral edema (sorbitol, dexamethasone) thiab saib xyuas tus neeg mob lub sijhawm.

Daim ntawv tso tawm

1 mg ntsiav tshuaj naj npawb 30, 60, 90, 120.
2 mg ntsiav tshuaj No. 30, 60, 90, 120.
3 mg ntsiav tshuaj No. 30, 60, 90, 120.

1 ntsiav tshuaj muaj glimepiride 1, 2 lossis 3 mg.
Lwm Cov Khoom xyaw: Lactose Monohydrate, Pob Kws Cais, Sodium Hmoov Txhim Kho Glycolate (Hom A), Polysorbate 80, Povidone, Talc, Magnesium Stearate.

Kev piav qhia ntawm cov tshuaj Alatar

Alatar yog yeeb tshuaj cuam tshuam nrog cov tshuaj tua kab zoo nrog kev ua haujlwm dav.Vim tias cov ua tau zoo dhau los ntawm ob qhov sib txuas ntawm cov tshuaj malathion thiab cypermethrin, cov cuab yeej tshem tawm sai sai ntawm cov tsiaj ntawm 28 hom tsiaj ntau.

Txij li ob lub ntsej muag no ua tiav cov haujlwm zoo, Alatar tau ua tiav zoo nrog thawj cov kab ntawm cov kab, cov neeg coob thiab nthuav cov neeg loj.

Kev Sib Sau thiab daim ntawv ntawm tso tawm

Txhawm rau kom ua tau zoo ntawm Alatar, nws cov muaj pes tsawg leeg suav nrog cov khoom tseem ceeb thiab pabcuam:

• Milatonin, cuam tshuam nrog cov organic phosphate compound. Cov txheej txheem muaj cov tshuaj lom tsis haum rau cov kab ntau uas tau noj zaub, txiv hmab txiv ntoo thiab cov paj ntoo kom zoo nkauj,
• Cypermethrin yog tshuaj lom neeg pyrethroid ua sai uas qhov kev txiav txim siab ua rau tuag tes tuag taw hauv kab,
• Nto nquag sib txuas, txhawm rau txhim kho cov teebmeem ntawm thawj ob lub ntsiab lus nquag,
• Cov kuab tshuaj ntxiv, cov tshuaj ua kom lub zog thiab cov khoom siv tiv thaiv kab mob.

Mechanism ntawm kev txiav txim ntawm cov kab tsuag

Cov tshuaj, vim qhov ua haujlwm nquag thiab nrawm ntawm ob lub cev muaj txiaj ntsig ib zaug, nkag mus rau txoj hnyuv ntawm cov kab, lossis cov kab menyuam ua haujlwm ntawm lub paj hlwb, ua rau tuag tes tuag taw. Raws li kev txiav txim immobilization thiab tsis tuaj yeem noj, cov kab tsuag tuag tau sai heev.

Tsis tas li ntawd, Alatar muaj qhov tshwj xeeb pab cov ntsiab lus, ua tsaug uas cov tshuaj lom chob rau ntawm cov nplooj thiab cov nplooj ntoo ua ntu zus rau lub sijhawm ntev. Txawm tias tom qab tso dej hnyav lossis los nag, cov nyhuv ntawm Alatar tsis xaus, vim tias vim muaj cov yam ntxwv nplaum nws tseem nyob rau ntawm nplooj tom qab ntsib nrog dej.

Cov Tshuaj Hauv Tshuaj

Cov tshuaj glimepiride ua rau cov ntshav qab zib tsawg dua. Cov tshuaj yog siv rau kev kho nrog ib qho tshuaj insulin-tiv thaiv ntshav qab zib. Cov kev ua haujlwm nquag ua feem ntau los ntawm kev ua kom cov insulin tso tawm ntawm pancreatic β-cells. Qhov kev txiav txim no tshwm sim vim muaj qhov nce ntawm cov lus teb ntawm β-hlwb rau kev ua kom lub zog ntawm lub cev kev xeeb los ntawm cov suab thaj.

Glimepiride pab cov tshuaj insulin zais los ntawm kev cuam tshuam cov kab mob potassium, uas yog nyob ntawm ATP cov ntsiab lus (nyob sab hauv lub qog ntawm β-hlwb). Tsis tas li ntawd, cov tshuaj yeeb yaj kiab muaj qhov ua kom zoo ntxiv, ua rau qhov mob rhiab heev ntawm cov ntaub so ntswg nrog rau kev hais txog cov tshuaj insulin, nrog rau kev txo qis ntawm hepatic nqus ntawm insulin.

Cov Tshuaj Pharmacokinetics

Tom qab noj, glimepiride qhia tau hais tias ua tiav kev nyab xeeb. Noj khoom ib nyuag qhov cuam tshuam kev nqus ntawm cov tshuaj - nws qhov degree hauv qhov no yog txo qis me ntsis. Ncov ntshiab qhov tseem ceeb tau sau tseg tom qab 2.5 teev tom qab kev noj mov ntawm cov ntsiav tshuaj sab hauv. Ncov qhov tseem ceeb hauv cov ntshav ntshav linearly sib txheeb nrog cov tshuaj ntau npaum li cas.

Glimepiride muaj qhov ntsuas qhov tsawg ntawm kev faib tawm ntim (txog 8.8 l), uas zoo ib yam li ntawd rau albumin. Cov khoom kuj tseem muaj cov theem siab ntawm cov protein ua ke (ntau tshaj li 99%) thiab kev kuaj pom tsawg (48 ml / feeb).

Ib nrab-lub neej ntawm ntshav cov ntshav kwv yees li 5-8 teev. Tom qab siv ib zaug tshuaj xwb, cov theem ntawm cov xov tooj cua tau sau cia: hauv cov zis, 58%, thiab hauv cov quav, 35%. Hauv qhov no, qhov hloov pauv tsis tau hloov pauv tsis tau sau tseg hauv cov zis.

Kev sib cuam tshuam nrog lwm yam tshuaj

Thaum muab cov tshuaj sib xyaw nrog cov tshuaj rau ib tus neeg, ib qho kev txo qis lossis ib qho kev xav tsis txaus siab nyob rau hauv nws cov hypoglycemic siv tau. Glimepiride cuam tshuam rau lub cev nrog kev pab los ntawm hemoprotein P450 2C9. Nws tau raug tshaj tawm tias cov txheej txheem hauv metabolic ntawm cov tshuaj no cuam tshuam los ntawm cov neeg ua kom siv sib xyaw (xws li rifampicin) lossis inhibitors (xws li fluconazole) ntawm hemoprotein P450 2C9.

Qhov nce hauv hypoglycemic nyhuv ntawm Altara tshwm sim nyob rau hauv rooj plaub ntawm kev sib xyaw nrog sulfinpyrazone, thiab ntxiv nrog oxyphenbutazone, azapropazone thiab phenylbutazone. Cov nyhuv tib yam tshwm sim thaum sib txuas nrog cov tshuaj nrog cov tshuaj hypoglycemic hauv qhov ncauj, tetracyclines, MAOI, sulfonamides (nrog kev tiv thaiv ntev), insulin, PASK thiab salicylates. Ntxiv rau, nrog kev sib deev cov tshuaj hormones (txiv neej) thiab tus neeg sawv cev anabolic, tshuaj tua kab mob los ntawm pawg quinolone derivative, ntxiv rau probenicide, chloramphenicol, fenfluramine, coumarin anticoagulants thiab miconazole nrog pentoxifylline (tshuaj loj). Cov npe no suav nrog ACE inhibitors, fibrates, fluoxetine nrog tritokvalin, sympatholytics, allopurinol, trophosphamide thiab cyclophosphamide, zoo li fluconazole thiab ifosfamide.

Qhov kev ua kom tsis muaj zog ntawm hypoglycemic ntawm cov tshuaj tshwm sim nyob rau hauv kev sib xyaw nrog progestogens thiab estrogens, zoo li thiazide diuretic tshuaj, saluretics, cov thyroid muaj nuj nqi tshuaj, epinephrine thiab GCS, thiab raws li sympathomimetics thiab phenothiazine derivatives nrog chlorpromazine. Tsis tas li thaum ua ke nrog niacin thiab nws cov derivatives, phenytoin, laxatives (nrog lawv siv ntev), glucagon thiab diazoxide, thiab ntxiv nrog rifampicin, barbiturates thiab acetazolamide.

Cov tshuaj uas thaiv β-adrenergic receptors thiab H2-kawg, thiab ntxiv rau, clonidine nrog reserpine tuaj yeem ob qho tib si potentiate thiab ua kom cov nyhuv tsis muaj zog hypoglycemic ntawm cov tshuaj. Nyob hauv kev cuam tshuam ntawm sympatholytics (ntawm lawv clonidine nrog reserpine, cov tshuaj uas thaiv β-adrenergic receptors, zoo li guanethidine), cov txiaj ntsig ntawm qhov ua rau adrenalergic nyhuv, uas ua rau txo qis dua qhov tseem ceeb, yuav txo qis lossis ploj tag nrho.

Glimepiride cuam tshuam los yog potentiates qhov cuam tshuam ntawm coumarin derivatives.

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Kev phiv tshuaj

Cov kev faib tawm hauv qab no yog siv los ntsuas qhov tshwm sim ntawm qhov tshwm sim tsis zoo: ntau heev> 1/10, feem ntau:> 1/100 thiab 1/1000 thiab 1/10 000 thiab 1)

1) Thrombocytopenia, leukopenia, erythrocytopenia, granulocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, uas, raws li txoj cai, ploj thaum cov tshuaj txiav tawm, tuaj yeem pom.

2) Kev ua kom tsis haum pes tsawg tuaj yeem hloov mus rau qhov kev txhaum hnyav nrog kev txhim kho ntawm kev ua pa luv, mob ntshav tawm hws, thiab qee zaum nrog kev txhim kho ntawm kev poob siab.

3) Kev rov qab kho lub siab tsis sib thooj feem ntau tshwm sim tam sim ntawd, tuaj yeem hnyav thiab tsis yooj yim los kho qhov tseeb.

4) Kev tsis pom kev zoo tuaj yeem pom tau tshwj xeeb tshaj yog nyob rau theem pib ntawm kev kho thiab yog tshwm sim los ntawm qhov hloov pauv ntawm cov concentration ntawm cov piam thaj hauv cov ntshav.

5) Kev yws ntawm cov hnyuv qee zaum ua rau thim tawm ntawm kev kho.

6) Kab mob siab tuaj yeem ua rau daim siab ua haujlwm.

Siv thaum cev xeeb tub thiab lactation

Tsis muaj cov ntaub ntawv txaus ntawm kev siv glimepiride rau cov poj niam cev xeeb tub, yog li nws yuav tsum tsis txhob siv tag nrho lub sijhawm.

Tsis paub meej, glimepiride kis mus rau niam mis. Vim tias lwm qhov sulfonylureas nkag mus rau hauv niam mis, muaj qhov pheej hmoo ntawm lub qog ntshav ntshav hauv menyuam, yog li ntawd, thaum siv cov tshuaj glimepiride, kev pub mis niam yuav tsum tsis ua mus ntxiv.

Glimepiride yuav tsum tsis txhob siv rau menyuam yaus vim yog kev kawm tsis tau txaus.

Nkees ntawm kev tua kab?

Nyob hauv lub tebchaws lossis hauv chav tsev kab laum, nas lossis lwm yam tsiaj muaj kiav txhab? Koj yuav tsum tawm tsam nrog lawv! Lawv yog cov muaj tus kab mob loj: salmonellosis, mob vwm.

Coob tus neeg nyob hauv lub caij ntuj sov ntsib kab tsuag uas ua rau cov qoob loo puas thiab ua kom cov ntoo puas.

Nyob rau hauv cov xwm txheej zoo li no, peb cov nyeem nyeem pom zoo kom siv cov kev tawm tsam tshiab tshaj plaws - kab tsuag Kab Tsuag Tsuag.

Nws muaj cov khoom nram qab no:

• Nws txo cov yoov, kab laum, nas, ntsaum, ntsaum
• Muaj kev nyab xeeb rau menyuam yaus thiab tsiaj
• Mains powered, tsis muaj recharging yuav tsum tau
• Tsis muaj cov nyhuv ntxiv rau cov kab tsuag
• Thaj tsam loj ntawm kev ua ntawm lub ntaus ntawv

Daim ntawv thov nta

Cov ntsiav tshuaj yuav tsum tau siv tam sim ua ntej lossis noj mov.

Nrog kev noj zaub mov tsis xwm yeem lossis yog tias zaub mov hla dhau, kev siv glimepiride tuaj yeem ua rau lub qog ntshav qab zib. Cov tsos mob ntawm tus mob ntshav qab zib yog muaj peev xwm: mob taub hau, tshaib plab, xeev siab, ntuav, ntau zog, tsaug zog, pw tsaug zog, ntxhov siab lub xeev, txhoj puab heev, cuam tshuam kev saib xyuas ncua, lub sij hawm muaj tshuaj tiv thaiv, kev nyuaj siab, tsis meej pem, hais lus thiab pom kev tsis sib haum, tshee tshee, tshee tshee, paresis, hnov ​​lub siab tsis sib xws, kiv taub hau, tsis paub pab, tsis tuaj yeem tswj tus kheej, delirium, cramps, nkees thiab tsis nco qab nrog txoj kev txhim kho ntawm precoma thiab coma, ua pa nyuaj, bradycardia.

Ntxiv rau, cov tsos mob xws li tawm hws, txhaws qa daim tawv nqaij, ntxhov siab, tachycardia, mob ntshav siab, lub plawv dhia, lub ntsws angina pectoris, thiab lub plawv tsis zoo tuaj yeem cuam tshuam. Cov kev nthuav tawm ntawm cov neeg mob ntshav qab zib siab ntau yuav zoo ib yam li kev nthuav qhia los ntawm cov neeg mob stroke.

Lub xeev ntawm hypoglycemia tuaj yeem yuav tsum tau ib txwm tshem tawm sai sai los ntawm kev noj haus carbohydrates (qab zib). Khoom qab zib cuav hloov tsis zoo rau qhov no.

Los ntawm cov kev paub nrog lwm cov tshuaj sulfonylurea, nws paub tias hypoglycemia tuaj yeem rov tshwm sim dua txawm tias cov txiaj ntsig thaum pib tshwm sim. Kev mob ntshav qab zib tsawg lossis ntev heev, tswj kav ib ntus los ntawm kev siv cov piam thaj, yuav tsum tau siv tshuaj kho mob tam sim ntawd thiab, tej zaum yog mus pw hauv tsev kho mob.

Cov xwm txheej hauv qab no tuaj yeem ua rau kev txhim kho hypoglycemia: tus neeg mob tsis txaus siab lossis tsis muaj peev xwm koom tes nrog tus kws kho mob (tshwj xeeb tshaj yog rau cov neeg laus), cov zaub mov tsis zoo, noj zaub mov tsis xwm yeem, tsis noj zaub mov lossis tshaib plab, tsis sib xws ntawm kev siv lub cev thiab kev noj haus uas tsis pub yuag, hloov pauv kev noj zaub mov, kev siv cawv, tshwj xeeb ua ke nrog kev noj zaub mov hla, ua rau lub raum tsis zoo, ua haujlwm lub siab ua haujlwm, kev siv lub ntsej muag ntawm glimepiride, qee qhov mob tsis muaj txiaj ntsig ntawm cov kab mob endocrine, carbohydrate metabolism los yog ua raws li counter-regulator ntawm hypoglycemia (qee qhov tsis ua haujlwm ntawm cov thyroid caj pas, tsis txaus ntawm anterior pituitary lossis adrenal cortex), siv cov tshuaj ntxiv los ntawm lwm yam tshuaj.

Thaum kho nrog glimepiride, kev tshuaj xyuas tas li ntawm cov ntsuas hauv qab no yog qhov tsim nyog: ntshav qab zib thiab zis, glycosylated hemoglobin qib, daim siab ua haujlwm siab, daim duab ntshav (tshwj xeeb cov lej ntawm leukocytes thiab platelets).

Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem

Hauv cov neeg mob uas muaj ntshav qab zib mellitus, vim qhov tshwm sim ntawm lub xeev kev tiv thaiv hypo- lossis hyperglycemia, nrog rau kev sib txuas nrog qhov muag tsis pom kev, muaj peev xwm mloog tau tuaj yeem txo, uas tuaj yeem ua rau muaj kev phom sij thaum tsav tsheb lossis kev pabcuam hauv lub cev. Yog li, lawv yuav tsum tau qhia kom ua raws li cov kev tiv thaiv uas tsim nyog uas ua kom tsis txhob muaj kev phom sij thaum tsav tsheb. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov neeg mob uas feem ntau muaj qee lub sijhawm kub siab ntawm lub qog ntshav lossis txo qis lossis feem ntau tsis nco qab txog ntawm cov tsos mob uas pom tias yog hypoglycemia. Hauv cov xwm txheej zoo li no, kev tsim nyog ntawm kev tsav tsheb yuav tsum xav txog.

Cov chaw muag tshuaj

Kws tshuaj Glimepiride yog ib tus neeg sawv cev hypoglycemic zoo uas siv rau hauv kev kho mob rau cov neeg mob uas tsis muaj cov kab mob ntshav qab zib tsis muaj insulin-mellitus.

Cov Tshuaj PharmacokineticsXuas. Lub bioavailability ntawm glimepiride tom qab nws cov lus tswj hwm tau ua tiav. Noj tsis cuam tshuam loj heev rau kev nqus, tab sis tus nqi ntawm kev nqus tsawg dua me ntsis. Qhov siab tshaj plaws hauv kev ntxhiab ntshav (C _max ) tom qab noj tau tiav tom qab 2.5 teev (thaj tsam nruab nrab 0.3 μg / ml nrog kev tswj xyuas dua ib zaug ntawm 4 mg rau ib hnub), thiab kev sib txuas ntawm cov koob tshuaj thiab C raug pom _max raws li thaj chaw thaj tsam nyob rau hauv cov concentration-time nkhaus (AUC).

Kev xa Khoom. Hauv glimepiride, qhov faib me me kom ntau (txog 8,8 litres) yog kwv yees li ntawm hauv albumin, cov qib siab ntawm cov protein khi (> 99%) thiab kev tshem tawm me me (li 48 ml / min).

Metabolism thiab tshem tawm. Ib nrab-lub neej ntawm ntshav dej yog li 5-8 teev. Tom qab txhaj ib koob tshuaj glimepiride nrog lub xov tooj cua, hnov ​​mob tshwm sim hauv cov zis (58%) thiab quav (35%). Kev nquag ua haujlwm ntawm cov zis tsis tau tshwm sim. Ob lub cev roj tau teev nyob rau hauv cov zis thiab cov quav: lub hydroxy derivative thiab carboxypochidne glimepiride. Tom qab noj glimepiride, qhov kawg ib nrab-lub neej ntawm cov metabolites yog 3-6 teev thiab 5-6 teev, ua ntu zus. Thaum muab piv ib zaug rau kev nkag ib hnub thiab ib zaug thiab rov ua qhov sib txawv tseem ceeb tsis tau pom dua, thiab tus kheej ntawm kev hloov pauv tsis loj heev. Tsis muaj qhov tseem ceeb uas tau sau tseg. Ib qho zoo sib txawv ntawm cov khw muag tshuaj tau pom hauv cov txiv neej thiab poj niam, nrog rau cov neeg mob hnub nyoog yau thiab cov neeg mob hnub nyoog laus dua 65 xyoos.

Cov Neeg Tsim Khoom

Ntau lawm:

Qhov chaw nyob. X-17 / X-18, O.I.D.Ts., Mahatma Gandhi Udiog Nagar, Dubhel, Daman 396210, Is Nrias teb.

Hauv kev tsim khoom, kev ntim khoom kawg, kev tsim tawm:

A.Menarini Kev Lag Luam Logistics thiab Kev Pabcuam S.r.l.

Qhov chaw nyob. Ntawm Campo di Pawg 67100 L'Aquila (AK), Ltalis.

A. Menarini Chaw Tsim Tshuaj & Kev Pabcuam S.r.l.

Qhov chaw nyob. Ntawm Sete Santi 3, 50131 Florence (FI), Ltalis.

Khaws Alatar

Alatar muaj qhov cuam tshuam ntau yam, nws muaj kev puas tsuaj rau colorado, codling npauj, ntsiab tawv dawb, scoops, kab laum, aphids, qa, caj pas, daj, whiteflies, weevils, zuam thiab ntau lwm yam kab uas ua mob rau ntau lub vaj thiab nroj tsuag hauv tsev. Kev siv cov tshuaj muaj peev xwm raug faib ua kev kho rau cov ntoo hauv tsev, cog qoob loo qoob loo.

Rau sab hauv nroj tsuag

Kev kho cov paj hauv tsev thiab cov paj hauv tsev zoo nkauj yog kev coj ua zoo los ntawm kev thov Alatara. Tab sis kev ua tiav yuav tsum muaj kev ceev faj tshwj xeeb, txij li tus txheej txheem yog nqa tawm ntawm thaj chaw muaj huab cua tsis muaj chaw dim pa.

Kev ua cov ntoo hauv tsev los ntawm Alatar yog nqa tawm rau:

• Tau tshem tawm aphids, thrips, npauj thiab lwm yam kab uas pub rau cov paj hauv tsev thiab tsob ntoo,
• Yuav kom tawm tsam kab devouring ornamental shrubs loj hlob sab hauv tsev,
• Txhawm rau tiv thaiv cov tsos ntawm mob khaub thuas thiab tsis suav nrog lawv rov qab los.

Rau horticultural qoob loo

Ntawm dachas thiab zaub vaj, Alatar yog siv los ntawm yuav luag txhua thib ob paub txog lub vaj, vim hais tias nrog nws, teeb meem zoo li no nrog paj, zaub thiab txiv hmab txiv ntoo thiab cov txiv ntoo yog cov daws:

• Thov siv cov cuab yeej siv rau kev ceev nrawm ntawm Colorado qos kab,
• Txhawm rau tshem ntawm cov ntoo ntawm devouring npauj thiab nplooj ntoos,
• Yuav kom cais tawm cov tsos thiab tawm tsam zoo tib yam, tshwj xeeb thiab currant aphids,
• Tua cov kab uas ua rau txiv hmab txiv ntoo thiab cov txiv ntoo nplev, xws li weevils,
• Rau extermination ntawm kab devouring zaub cov qoob loo, nyob rau hauv cov yam ntxwv ntawm lub daus, cabbage ya, whitewash, npauj thiab nplooj phaj,
• Txhawm rau kom muaj kev tiv thaiv kev tiv thaiv kev zoo nkauj lossis rov qab los ntawm txhua tus kab npe thiab lwm yam.

Cov nqi yuav khoom

Ua raws li qhov haujlwm tshwj xeeb tau teeb tsa thaum siv tshuaj tua kab, tus nqi ntawm nws tau txais kev pab thaum txau kuj tseem yuav hloov.

Cov qauv tseem ceeb rau kev ua ntawm ntau cov qoob loo cog:

• Txhawm rau tawm tsam Colorado, weevil thiab lwm yam kab uas pub zaub rau cov qoob loo zaub, 5 ampoule yog diluted nrog 4 liv dej. Txau yog ua tiav thaum lub caij ua paj, nrog kev siv ntawm 4 liv cov hmoov tshauv uas tau txais hauv 100m2.
• Rau kev tsim txom ntawm ib qho kev yoov dos, ob txoj kev kho mob twb tau ua nrog kev daws tib yam li rau Colorado.
• Lub extermination ntawm lub stalk thiab leaflet koom ua nrog ib ampoule ntawm yeeb tshuaj, diluted nyob rau hauv 10 liv dej.Txau 5 liv thaum tawm tsob ntoo.
• Txhawm rau rhuav tshem aphids, 5 ml ntawm cov tshuaj yaj yog yaj hauv 5 liv dej. Kev ua haujlwm yuav tsum yog nyob rau lub sijhawm cog qoob loo ntawm 1 liv ib tsob ntoo.
• Kev tiv thaiv thiab kev kho mob ntawm cov paj zoo nkauj thiab thaj av tawg yog nqa nrog kev daws teeb meem hauv qhov sib piv ntawm 10 liv dej rau ib qho roj. Ib qho av nkos tsis ntau tshaj 5 liv cov hmoov tshauv ib 100 sq.m. cog thaj tsam.

Tshuaj kho mob nkeeg

Thaum kev daws teeb meem xav tau rau cov nroj tsuag tau npaj, lawv dhau mus txias-los ntshav kev tsim txom.

Cov lus qhia rau tshuaj tsuag cov ntoo nrog Alatar:

• Ua tib zoo saib qhov ntsuas ntawm kev txau nrog tshuaj yaj yeeb, cov nplooj ntawm cov ntoo tau raug kho siv rab phom txau,
• Txau yog nqa tawm ntawm hnub qhuav thiab tom qab ywg dej,
• Qhov kev taw qhia ntawm qhov cua yuav tsum tau coj mus rau hauv tus account, txij li yeeb tshuaj yuav tsum tsis txhob tawm cov nroj tsuag dhau los,
• Ntawm txoj kev nws yuav tsum tsis txhob kub siab tshaj 25 degrees (lossis qis dua 12 degrees ntawm tshav kub), txij li tsis saib xyuas qhov ntsuas kub tsis zoo muaj qhov tsis zoo rau lub sijhawm ntawm kev ua ntawm cov kev sib txuas.

Kev tiv thaiv kev nyab xeeb

Thaum lub sij hawm txau tus neeg yuav tsum muaj qhov kaw nrog lub tes tsho ntev. Lub ntsej muag yuav tsum muaj lub npog ntsej muag lossis lub tshuab ua pa, thiab cov tsom iav, txij li kev sib cuag ntawm cov tshuaj lom neeg nrog cov nqaij mos lossis qhov muag tuaj yeem tawm lub teeb hlawv.

Yog tias Alatar tau txais ntawm daim tawv nqaij lossis cov nqaij mos, lossis qhov muag - cov chaw no yuav tsum tau muab yaug tam sim ntawd nrog dej sov kom ntau.

Qhov twg yuav thiab ntau npaum li cas yog cov tshuaj?

Yuav Alatar tsis yog qhov nyuaj, tsuas yog nug txog qhov muaj ntawm cov tshuaj hauv cov khw tshwj xeeb. Ntxiv mus, tus nqi ntawm cov khoom yog muaj kev ywj pheej heev, vim tias rau lub raj mis nrog 25 ml koj yuav tsum them tsis tshaj 70-80 rubles.

Lossis koj tuaj yeem nrhiav cov tshuaj hauv Is Taws Nem. Ib qho chaw muaj ntau ntawm thaj chaw muab ib lub sijhawm tsis tsuas yog xaj cov tshuaj hauv tsev, tab sis kuj muab tswv yim rau kev siv. Tus nqi hauv lub network yuav sib txawv ntawm 40 txog 70 rubles rau 25 ml ntawm Alatar.

Pharmacological kev txiav txim

Cov tshuaj tseem ceeb yog glimepiride - ib qho kev tiv thaiv hypoglycemic zoo siv los kho cov neeg mob ntshav qab zib mellitus. Glimepiride txhawb kev tso tawm ntawm insulin los ntawm pancreatic β-cells. Cov nyhuv no cuam tshuam nrog kev teb ntau dua ntawm β cov hlwb ua rau lub ntsej muag ua rau lub siab. Glimepiride muaj ua tiav kev noj qab haus huv tom qab kev tswj hwm qhov ncauj. Noj mov tsis cuam tshuam loj heev rau kev nqus ntawm cov tshuaj, muaj tsuas yog txo qis nyob rau hauv cov degree ntawm nqus. Qhov siab tshaj plaws ntawm cov tshuaj hauv cov ntshav yog kaw 2.5 teev tom qab kev tswj hwm ntawm qhov ncauj. Ib txoj kab sib txuas ntawm qhov ntau npaum ntawm glimepiride thiab nws qhov siab tshaj plaws hauv cov ntshav cov ntshav tau sau tseg. Glimepiride muaj cov khoom faib me me (kwv yees 8,8 L), sib thooj rau cov albumin, cov qib siab ntawm cov lus sib txuas rau cov ntshav plasma protein (ntau dua 99%) thiab tsis tshua pom tseeb (48 ml / min).

Ib nrab-lub neej ntawm ntshav dej muaj pes nrab li 5-8 teev. Nrog rau kev tswj hwm ib zaug ntawm glimepiride nrog cov ntawv sau tshuaj, lub xov tooj cua ntawm cov zis (58%) thiab cov quav (35%) tau sau cia. Cov tshuaj tsis hloov pauv nyob hauv cov zis tsis tau txiav txim. Thaum muab piv rau ntau qhov tshuaj thiab ib zaug, cov tshuaj pharmacokinetics ntawm cov tshuaj tsis hloov pauv ntau yam, thiab tus neeg thaj tsam ntawm qhov hloov pauv tsis txawv txav. Qhov kev sib txuam tseem ceeb kuj tsis pom. Hauv cov txiv neej thiab poj niam, zoo li hauv cov hluas thiab cov laus (ntau dua 65 xyoos), cov tshuaj zoo sib xws ntawm cov tshuaj muaj npe tau sau tseg. Ib qho kev xav txog qhov txo qis ntawm cov ntsiab lus ntawm glimepiride hauv cov ntshav cov ntshav tau pom nyob rau hauv cov tib neeg muaj qib creatinine tsawg, uas tej zaum yuav cuam tshuam nrog kev tshem tawm sai dua ntawm cov tshuaj nquag (vim muaj qhov tsawg ntawm kev khi rau cov ntshav plasma). Kev nce ntxiv ntawm cov tshuaj hauv pawg neeg mob no tsis pom tshwm sim.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev tswj fwm ntawm cov tshuaj Altar nrog rau lwm cov tshuaj, qhov ua kom tsis muaj zog los yog tsis muaj qhov xav tau nyob hauv nws lub qog hypoglycemic. Glimepiride muab nws cov nyhuv los ntawm cytochrome P450 2C9. Nws yog qhov ua pov thawj tias kev siv ua ke ntawm kev ua kom zoo (piv txwv, rifampicin) thiab cytochrome P450 2C9 inhibitors (fluconazole) cuam tshuam rau cov metabolism ntawm glimepiride.
Kev nce hauv hypoglycemic lub zog ntawm cov tshuaj Altar tau pom thaum nws siv ib txhij nrog phenylbutazone, azapropazone, oxyphenbutazone, sulfinpyrazone, tshuaj tiv thaiv kab mob hauv lub qhov ncauj, insulin, sulfanilamides nrog kev siv lub sijhawm ntev, tetracyclines, salicylates thiab PASA, tshuaj txiv neej, tshuaj anabolic thiab cov tshuaj anabolic. , chloramphenicol, probenicide, coumarin anticoagulants, miconazole, fenflura mees, pentoxifylline (per os hauv qib siab), fibrates, tritokvalin, ACE inhibitors, fluoxetine, allopurinol, sympatholytic, cyclophosphamide, trophosphamide, ifosfamide, fluconazole.

Kev txo qis hauv cov khoom hauv hypoglycemic ntawm Altar yog pom thaum nws siv ib txhij nrog estrogens thiab progestogens, saluretics, thiazide diuretics, cov neeg sawv cev uas txhawb cov kev ua haujlwm ntawm cov thyroid caj pas, GCS, phenothiazine thiab chlorpromazine derivatives, epinephrine thiab sympathomimetics, nicotinic acid thiab nws cov thiv thivas , finitoin, diazoxide, glucagon, barbiturates, rifampicin, acetazolamide.
Β-adrenergic blockers thiab H2-receptor blockers, reserpine thiab clonidine tuaj yeem yog qhov tsis muaj zog lossis txhim kho hypoglycemic lub zog ntawm cov tshuaj Altar. Nyob hauv kev cuam tshuam ntawm sympatholytics xws li reserpine, guanethidine, clonidine, thiab β-adrenergic blockers, cov nyhuv ntawm kev txiav txim siab adrenergic ntawm kev txo qis hauv qabzib yuav ua kom tsis muaj zog lossis tsis tuaj. Glimepiride ua kom tsis muaj zog lossis txhim kho qhov cuam tshuam ntawm coumarin derivatives.