Diamerid 1

Daim ntawv rau lub koob tshuaj rau tso Diameride yog cov ntsiav tshuaj: tiaj-cylindrical, nrog ib tug bevel, qhov kev tso tawm me ntsis raug tso cai, 1 thiab 3 mg txhua qhov yog xim paj yeeb nrog lub xim av daj, 2 thiab 4 mg txhua tus yog los ntawm daj lossis lub teeb daj mus rau xim xim (hauv blister pob ntawm 10 pcs. ., hauv daim thawv ntawv tuab ntawm 3 lossis 6 pob khoom).

Composition 1 ntsiav tshuaj:

• cov tshuaj nquag: glimepiride - 1, 2, 3 lossis 4 mg (hauv 100% tshuaj),
• Cov khoom siv pabcuam (1/2/3/4 mg): magnesium stearate - 0.6 / 0.6 / 1.2 / 1.2 mg, lactose monohydrate - 78.68 / 77.67 / 156.36 / 155, 34 mg, croscarmellose sodium - 4.7 / 4.7 / 9.4 / 9.4 mg, povidone - 2.5 / 2.5 / 5/5 mg, poloxamer - 0.5 / 0.5 / 1 / 1 / mg, microcrystalline cellulose - 12/12/24/24 mg, daj tso xim hlau oxide - 0 / 0.03 / 0 / 0.06 mg, xim liab zas hlau oxide - 0.02 / 0 / 0.04 / 0 mg

Cov Yuav Tsum Tau Ua

• lactose intolerance, lactase deficiency, qabzib-galactose malabsorption,
• leukopenia
• ketoacidosis, mob ntshav qab zib coma thiab precoma,
• ntshav qab zib hom 1
• tej yam kev mob uas cuam tshuam nrog kev nqus ntawm cov zaub mov thiab kev txhim kho hypoglycemia (suav nrog cov kis mob),
• kev ua tsis taus ntawm ob lub raum / nplooj siab hauv qhov mob hnyav (suav nrog rau cov mob hemodialysis,)
• cev xeeb tub thiab lactation,
• hnub nyoog txog 18 xyoo
• cov tib neeg tsis haum rau cov tshuaj, suav nrog hypersensitivity rau lwm cov sulfonylurea derivatives los yog sulfonamide tshuaj (cuam tshuam nrog kev muaj peev xwm ntawm kev tsis haum lub siab).

Kev muab tshuaj Diameride xav kom ceev faj thaum muaj tej yam kev hloov pauv ntawm tus neeg mob mus rau kev kho mob insulin, suav nrog kev kub hnyiab ntau, kev phais mob loj, ntau qhov kev raug mob hnyav, malabsorption ntawm cov zaub mov thiab tshuaj los ntawm kev mob plab (lub plab zom mov, lub plab hnyuv).

Thaum cev xeeb tub tshwm sim lossis qee qhov xwm txheej ntawm nws txoj kev npaj, ib tus poj niam yuav tsum pauv mus rau kev kho mob insulin.

Tsuas tshuaj thiab tswj hwm

Diameride noj tau qhov ncauj.

Cov ntsiav tshuaj tau noj yam tsis muaj kev zom, tag nrho, nrog cov tshuaj txaus (li 100 ml). Tom qab noj cov tshuaj, hla zaub mov tsis pom zoo.

Tus kws kho mob txiav txim muab ntau npaum li cas rau lub cev, los ntawm cov txiaj ntsig kev soj ntsuam tsis tu ncua ntawm cov ntshav qabzib hauv siab.

Thaum pib ntawm kev kho mob, diamerid raug xaj 1 mg rau ib hnub. Tom qab ua tiav txoj kev kho kom zoo dua, cov tshuaj no tau pom zoo kom coj los ua kev saib xyuas txij nkawm.

Thaum tsis muaj kev tswj kav glycemic, kev noj tshuaj txhua hnub yuav tsum maj mam (nrog ntu li 1-2 lub lis piam) nce ntxiv los ntawm kev saib xyuas cov ntshav qabzib ntau rau 2, 3 lossis 4 mg ib hnub. Kev txhaj tshuaj ntau dua yog muaj txiaj ntsig tshwj xeeb. Qhov siab tshaj plaws - 6 mg ib hnub twg.

Lub sijhawm thiab ntau zaus ntawm kev siv tshuaj yog txiav txim los ntawm tus kws kho mob. Cov txheej txheem ntawm daim ntawv thov ntawm diamerid yuav tsum coj mus rau hauv tus neeg mob lub neej. Cov koob tshuaj txhua hnub yuav tsum tau noj hauv 1 koob tshuaj tam sim ua ntej lossis thaum noj mov tshais lossis thawj thawj pluas noj.

Diameride yog npaj rau kev kho mob mus ntev, uas yuav tsum tau ua nyob rau hauv kev tswj hwm ntawm cov ntshav qabzib.

Thaum tsis muaj glycemic tswj nyob rau hauv cov neeg mob noj cov tshuaj metformin, Diameride kuj yuav raug ntxiv ntxiv.

Qhov koob tshuaj ntawm metformin feem ntau tsis hloov; thaum pib ntawm txoj kev kho, diamerid yuav tsum tau sau tseg nyob rau hauv qhov tsawg kawg nkaus, uas yog maj mam nce mus txog qhov siab tshaj plaws. Kev sib xyaw ua ke yuav tsum tau ua nyob rau hauv kev saib xyuas zoo ntawm tus kws tshaj lij.

Yog tias kev tswj glycemic tsis tuaj yeem ua tiav thaum noj ntau kawg ntawm Diameride raws li kev kho mob monotherapy, cov tshuaj insulin ntxiv tuaj yeem raug, uas tau sau tseg rau hauv koob tshuaj tsawg kawg thaum pib kho. Yog tias tsim nyog, yuav tsum maj mam nce ntxiv. Kev sib xyaw ua ke yuav tsum tau ua nyob rau hauv kev saib xyuas zoo ntawm tus kws tshaj lij.

Thaum hloov mus rau tus neeg mob los ntawm lwm qhov tshuaj hypoglycemic hauv qhov ncauj rau Diameride, nws thawj koob tshuaj txhua hnub yuav tsum yog 1 mg (txawm tias tus neeg mob hloov los ntawm qhov ntau tshaj ntawm lwm qhov tshuaj hypoglycemic hauv qhov ncauj). Ib qho kev nce qib twg hauv koob tshuaj Diameride yuav tsum tau ua nyob rau theem ua raws li cov lus pom zoo saum toj no. Cov txiaj ntsig, qhov tshuaj thiab lub sijhawm thiab ua haujlwm ntawm cov ntawv thov hypoglycemic tus neeg sawv cev yuav tsum tau txiav txim siab. Muaj qee kis, tshwj xeeb tshaj yog thaum noj tshuaj hypoglycemic nrog lub sijhawm ntev ib nrab-lub neej, kev txiav tawm ib ntus ntawm kev kho mob tej zaum yuav tsum tau (rau ob peb hnub), uas yuav pab kom tsis txhob muaj qhov cuam tshuam ntxiv uas ua rau muaj kev txo qis ntawm hypoglycemia.

Thaum ua kev kho mob insulin rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, thaum them nyiaj rau tus kabmob thiab tswj cov haujlwm zais cia ntawm pancreatic cells-hlwb hauv qee qhov tshwj xeeb, insulin tuaj yeem hloov nrog Diamerid (thaum pib kho, qhov tshuaj tiv thaiv qis tshaj plaws yog siv). Kev txhais lus yuav tsum tau ua nyob rau hauv kev saib xyuas ze ntawm tus kws tshaj lij.

Sab sij huam

• khoom ntawm lub zeem muag: qhov tsis pom kev tsis pom tseeb (pom, raws li txoj cai, thaum pib ntawm txoj kev kho, vim yog qhov hloov pauv ntawm cov concentration ntawm cov piam thaj hauv cov ntshav),
• metabolism: hypoglycemic tshua (tshwm sim sai sai tom qab noj Diamerid thiab tuaj yeem tshwm sim hauv cov ntawv loj, tsis yog ib txwm txiav nres, lawv cov tsos yog feem ntau txiav txim siab los ntawm qee tus neeg, tshwj xeeb tshaj yog kev noj haus thiab cov koob tshuaj siv),
• hematopoietic system: thrombocytopenia (hauv kev kawm nruab nrab / mob hnyav), leukopenia, granulocytopenia, erythrocytopenia, aplastic / hemolytic anemia, pancytopenia, agranulocytosis,
• lub plab zom mov: ntuav, xeev siab, tsis xis nyob / hnyav nyob hauv epigastrium, mob lub plab, mob plab (tso tseg cov tshuaj hauv qee qhov tsis tshua muaj), ntau ntxiv kev ua haujlwm ntawm daim siab enzymes, daj ntseg, cholestasis, mob siab (qee zaum nrog kev loj hlob ntawm daim siab tsis ua haujlwm),
• dermatological tshua: nyob rau qee qhov xwm txheej, ua kom pom tseeb tseeb kom zoo nkauj zoo nkauj, ua kom lub ntsej muag zoo nkauj,
• kev ua xua: urticaria (nyob rau hauv daim ntawv ua kom khaus, tawm pob ntawm daim tawv nqaij, feem ntau yog me ntsis, tab sis tuaj yeem vam meej, nrog ua pa luv, poob ntshav nce siab, nce mus rau qhov tshwm sim ntawm anaphylactic poob siab, xav tau kev kho mob sai sai), khaub thuas ua xua nrog rau lwm yam sulfonamides, derivatives ntawm sulfonylureas lossis lwm yam sulfonamides, kev tsis haum tshuaj vasculitis,
• lwm tus: hauv qee kis - hyponatremia, asthenia, mob taub hau.

Cov lus qhia tshwj xeeb

Cov neeg mob yuav tsum ua raws li cov tshuaj ntau npaum li cas. Kev rho tawm ntawm ib qho tshuaj xwb tsis tuaj yeem them nyiaj rau los ntawm kev tswj hwm tom qab ntawm qhov tau txais ntau dua.

Qhov tshwm sim ntawm hypoglycemia tom qab noj 1 mg ntawm diamerid txhais tau tias muaj peev xwm tswj glycemia ib leeg los ntawm kev noj haus.

Thaum them nyiaj rau cov ntshav qab zib hom 2 tau tiav, kev nce siab ntxiv ntawm cov tshuaj insulin. Hauv qhov no, nyob rau hauv kev kho mob siab, qhov xav tau Diameride yuav txo qis. Txhawm rau kom zam kev txhim kho hypoglycemia, koj yuav tsum tau txo qis ib ntus los yog tshem tawm txoj kev kho mob. Hloov tshuaj kuj tseem yuav tsum tau ua yog tias muaj kev hloov pauv hauv tus neeg mob lub cev, nws txoj kev ua neej, lossis thaum muaj lwm yam tshwm sim uas yuav ua rau muaj kev tiv thaiv kabmob ntshav siab lossis ntshav qis.

Txhawm rau kom tswj tau cov ntshav qabzib kom zoo nrog rau kev tswj cov tshuaj ib txwm muaj, nws yog ib qho tseem ceeb kom tswj kev noj zaub mov kom zoo thiab ua kom lub cev muaj zog thiab tawm dag zog.

Cov tsos mob soj ntsuam ntawm hyperglycemia suav nrog kev nqhis dej heev, ib qho kev nce ntxiv ntawm lub tso zis, daim tawv nqaij qhuav thiab lub qhov ncauj qhuav.

Hauv thawj lub asthiv ntawm kev siv Diamerid, qhov ntxim nyiam ntawm lub qog ntshav qab zib yuav nce ntxiv (hauv cov teeb meem no, tshwj xeeb yog ua tib zoo saib xyuas ntawm tus neeg mob yuav tsum tau). Yog tias koj noj noj tsis xwm yeem lossis pluas noj mov, kev muaj ntshav qab zib tsawg yuav tshwm sim.

Lub hauv paus tseem ceeb los pab ua kom qhov pib ntawm lub qog ntshav qab zib:

• qhov tsis txaus siab / qhov tsis muaj peev xwm (tshwj xeeb hauv cov neeg laus) ntawm tus neeg mob kom koom tes nrog tus kws kho mob,
• kev noj zaub mov tsis zoo, suav nrog cov kev hloov pauv ntawm kev noj haus ib txwm, tshaib plab, tsis xwm yeem / tsis muaj peev xwm noj zaub mov, tsis noj zaub mov,
• haus dej cawv, tshwj xeeb hauv kev sib xyaw nrog kev noj zaub mov ntau,
• npaus tsis txaus ntawm kev ua kom txaus thiab kev ua kom lub cev,
• tsis hnov ​​lus hepatic nyob rau hauv ib txoj kev mob hnyav,
• overdose ntawm diamerid,
• lub raum tsis ua hauj lwm zoo,
• ua ke siv nrog lwm yam tshuaj,
• qee qhov mob tsis txaus ntseeg ntawm cov kab mob endocrine uas cuam tshuam rau cov metabolism hauv kev ua kom yuag, nrog rau cov thyroid tsis ua hauj lwm, adrenal tsis txaus, lossis tsis meej pem pituitary.

Qhov pom / pom ntawm cov ntsiab lus saum toj no, nrog rau kev mob tshwm sim ntawm lub qog ntshav qab zib, yuav tsum ceeb toom rau tus kws kho mob, vim tias qhov xwm txheej no, tshwj xeeb tshaj yog saib xyuas kev mob ntawm cov neeg mob yog qhov yuav tsum tau ua. Yog tias cov xwm txheej tam sim no tshwm sim, yuav tau txhaj tshuaj / tag nrho kev hloov kho qhov yuav tsum tau ua. Kev ntsuas zoo ib yam li no thaum muaj kev sib kis lossis thaum tus neeg mob lub neej hloov pauv.

Hauv cov neeg mob laus, cov neeg mob autonomic neuropathy lossis cov neeg mob tau txais kev kho nrog conanitant nrog guanethidine, beta-blockers, reserpine, clonidine, cov tsos mob ntawm hypoglycemia tej zaum yuav smoothed lossis tag nrho qhaj ntawv.

Yuav luag txhua qhov teeb meem, hypoglycemia tuaj yeem nres sai sai los ntawm kev noj zaub mov sai sai ntawm cov carbohydrates (qab zib lossis piam thaj). Hauv qhov no, tus neeg mob yuav tsum tau muaj tsawg kawg 20 g piam thaj (4 daim piam thaj). Hauv kev kho mob ntawm hypoglycemia, cov khoom qab zib kuj tsis ua haujlwm.

Txawm hais tias thawj zaug kev vam meej hauv kev tso tseg kev mob ntshav qab zib, txoj kev txhim kho ntawm nws txoj kev huam mob tuaj yeem pom, uas yuav tsum tau soj ntsuam tas li ntawm tus neeg mob. Hauv cov ntshav khov ntau heev, yuav tsum tau kho tam sim ntawd los ntawm kev saib xyuas ntawm tus kws tshaj lij, thiab qee zaum pw hauv tsev kho mob.

Thaum kho, kev saib xyuas lub siab ua haujlwm tsis tu ncua thiab daim duab ntsig ntshav yuav tsum tau nqa tawm (tshwj xeeb, qhov no siv rau cov naj npawb ntawm cov plasmaets thiab cov qe ntshav dawb).

Hauv cov xwm txheej ntxhov siab (piv txwv, kev raug mob, phais, nrog mob sib kis ua npaws), tus neeg mob yuav tsum pauv mus rau insulin.

Tsis muaj kev paub txog kev siv cov diamerid hauv cov neeg mob uas lub raum / lub cev tsis ua haujlwm zoo hauv cov mob loj lossis hauv cov neeg mob ntawm hemodialysis (insulin yog qhia).

Thaum kho, cov concentration ntawm cov piam thaj hauv cov ntshav, nrog rau cov concentration ntawm glycosylated hemoglobin, yuav tsum tau saib xyuas tsis tu ncua.

Qee qhov kev phiv tshuaj tiv thaiv (ua rau muaj ntshav nce siab ntau ntau, hloov pauv hnyav hauv cov ntshav hauv ntshav, kev tsis haum tshuaj hnyav, daim siab ua haujlwm) nyob rau qee qhov xwm txheej yuav ua rau muaj kev phom sij txog lub neej. Yog tias muaj mob hnyav / tsis haum lub siab, tus neeg mob yuav tsum qhia tus kws tshaj lij txog lawv. Koj yuav tsum tsis txhob noj cov tshuaj koj tus kheej.

Thaum pib ntawm chav kawm, thaum hloov los ntawm ib cov tshuaj mus rau lwm qhov lossis nrog kev noj tsis haum ntawm Diameride, qhov txo qis ntawm kev mloog thiab qhov ceev ntawm lub hlwb psychomotor vim yog hyper- lossis hypoglycemia tej zaum yuav tshwm sim, uas cuam tshuam lub peev xwm tsav tsheb. Cov neeg mob yuav tsum tau ntsuas los tiv thaiv qhov tshwm sim ntawm cov mob no. Cov neeg mob uas tsis muaj / tau txo qis cov kev mob tshwm sim ntawm qhov ua ntej tshaj plaws yog qhia kom tsis txhob tsav lub tsheb.

Lub Npe Tsis Muaj Npe International

Lub npe thoob ntiaj teb nonproprietary rau cov tshuaj no yog glimepiride. Nws txhais tau cov tshuaj ua tau zoo. Cov khoom siv no yog tiam thib peb sulfonylurea derivative.

Diamerid yog cov tshuaj uas siv los txo cov ntshav piam thaj.

Txoj cai ntawm cov tshuaj raws li ATX (anatomical, kho thiab tshuaj sib cais) yog A10BB12. Ntawd yog, cov tshuaj no yog ib qho cuab yeej cuam tshuam rau txoj hnyuv hauv lub plab thiab cov metabolism, npaj siab rau kev tshem tawm cov ntshav qab zib, yog suav tias yog cov tshuaj hypoglycemic, lub zog ntawm sulfonylurea (glimepiride).

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Raws li txoj cai, cov koob tshuaj ntawm cov tshuaj yog txiav txim los ntawm lub hom phiaj concentration ntawm cov piam thaj hauv cov ntshav. Qhov tshuaj tiv thaiv qis qis txaus kom ua tiav qhov kev tswj hwm metabolic tsim nyog yuav tsum tau siv.

Thaum kho, nws yog qhov yuav tsum tau txiav txim siab tsis tu ncua cov concentration ntawm cov piam thaj hauv cov ntshav. Tsis tas li ntawd, kev soj ntsuam tas li ntawm glycosylated hemoglobin qib tau pom zoo.

Qhov tsis zoo ntawm kev siv tshuaj, piv txwv li, hla kev siv tshuaj ntxiv, yuav tsum tsis txhob ntxiv los ntawm kev noj tshuaj ntxiv tom qab ntawm qhov siab dua. Tus neeg mob cov kev coj ua thaum muaj qhov yuam kev thaum noj cov tshuaj (tshwj xeeb, thaum tsis txhaj koob tshuaj ntxiv lossis noj zaub mov noj) lossis cov xwm txheej tsis tuaj yeem siv tshuaj, yuav tsum tau tham nrog tus neeg mob thiab tus kws kho mob ua ntej.

Diameride noj tau qhov ncauj tsis noj, ntxau kom tsis muaj kua txaus (li 0.5 khob).

Thawj qhov tshuaj yog 1 mg ntawm glimepiride ib hnub ib zaug. Yog tias tsim nyog, cov koob tshuaj txhua hnub tuaj yeem hloov maj mam nce ntxiv (nyob rau ntu ntawm 1-2 lub lis piam). Nws raug nquahu tias qhov kev nce ntxiv yuav raug saib xyuas los ntawm kev saib xyuas cov ntshav qabzib hauv qab thiab kom raws li cov qib nce ntxiv hauv qab no: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg (- 8 mg).

Ntau npaum cov koob tshuaj nyob rau hauv cov neeg mob uas tswj tau tus mob ntshav qab zib mellitus: feem ntau koob tshuaj txhua hnub hauv cov neeg mob uas muaj ntshav qab zib kom zoo mellitus yog 1-4 mg ntawm glimepiride. Kev noj tshuaj txhua hnub ntau dua 6 mg yuav zoo dua hauv qee tus neeg tsawg xwb.

Lub sijhawm ntawm kev pub nkag thiab faib koob tshuaj rau txhua hnub yog txiav txim los ntawm tus kws kho mob, nyob ntawm tus neeg mob txoj kev ua neej nyob rau lub sijhawm muab sijhawm (sau lub sijhawm, tus lej ntawm kev siv lub cev).

Feem ntau, ib koob tshuaj ib zaug ntawm cov tshuaj thaum nruab hnub yog txaus. Nws pom zoo tias hauv qhov no, tag nrho cov tshuaj ntawm cov tshuaj yuav tsum tau noj tam sim ntawd ua ntej noj tshais tag nrho lossis, yog tias nws tsis noj nyob rau lub sijhawm ntawd, tam sim ntawd ua ntej thawj pluas noj.

Nws yog qhov tseem ceeb heev kom tsis txhob hla ib pluas noj tom qab siv cov tshuaj.

Txij li kev txhim kho metabolic tswj yog txuam nrog kev nce insulin rhiab heev, qhov xav tau rau glimepiride tuaj yeem txo qis thaum kho. Txhawm rau kom tsis txhob muaj kev txhim kho hypoglycemia, nws yog ib qho tsim nyog kom txo qis qhov koob tshuaj lossis tsum tsis txhob noj cov tshuaj no.

Cov mob uas yuav tau hloov cov tshuaj ntau ntxiv kuj yuav tsum muaj:

- txo lub cev qhov hnyav ntawm tus neeg mob,

- kev hloov pauv ntawm tus neeg mob lub neej (hloov kev noj haus, sijhawm noj mov, kev siv dag zog),

- kev tshwm sim ntawm lwm yam uas ua rau muaj kev cuam tshuam ua ntej rau kev txhim kho hypoglycemia lossis hyperglycemia.

Glimepiride kho mob feem ntau yog ua rau lub sijhawm ntev.

Hloov chaw ntawm tus neeg mob los ntawm kev noj lwm qhov tshuaj hypoglycemic rau kev noj tshuaj Diamerid: tsis muaj kev txheeb ze ntawm kev txhaj tshuaj ntawm glimepiride thiab lwm yam kev tiv thaiv hypoglycemic rau kev tswj hwm qhov ncauj.Thaum lwm tus neeg sawv cev hypoglycemic rau qhov ncauj tswj hwm tau hloov nrog glimepiride, nws raug pom zoo tias cov txheej txheem rau kev sau ntawv yuav tsum yog tib yam li rau kev teem sijhawm thawj zaug, uas yog, kev kho mob yuav tsum pib nrog thawj koob tshuaj 1 mg (txawm tias tus neeg mob pauv mus rau glimepiride nrog qhov siab tshaj plaws lwm qhov tshuaj hypoglycemic rau qhov ncauj tswj hwm). Qhov koob tshuaj nce ntxiv yuav tsum tau nqa tawm hauv theem, suav txog qhov lus teb rau glimepiride, raws li cov lus pom zoo saum toj no.

Nws yog ib qho tsim nyog yuav tsum coj mus rau hauv lub zog thiab lub sijhawm ntawm cov nyhuv ntawm yav dhau los hypoglycemic tus neeg sawv cev rau kev tswj hwm qhov ncauj. Kev cuam tshuam kev kho mob tej zaum yuav tsum kom tsis txhob muaj kev sib tham ntawm cov teebmeem uas yuav ua rau muaj kev pheej hmoo ntawm ntshav qab zib.

Siv ua ke nrog metformin

Hauv cov neeg mob uas tsis muaj peev xwm tswj tau tus mob ntshav qab zib mellitus, thaum noj ntau tshaj plaws txhua hnub ntawm ob qho tshuaj glimepiride lossis metformin, kev kho mob nrog kev sib xyaw ntawm ob hom tshuaj no tuaj yeem pib ua. Hauv qhov no, kev kho yav dhau los nrog rau glimepiride lossis metformin txuas ntxiv nyob rau tib theem li qub, thiab cov koob tshuaj ntxiv ntawm metformin lossis glimepiride pib nrog kev txhaj tshuaj qis, uas yog tom qab ntawv suav nyob ntawm lub hom phiaj theem ntawm kev tswj metabolic mus txog qhov siab tshaj plaws txhua hnub. Kev sib koom ua ke yuav tsum tau pib hauv kev saib xyuas mob nkeeg zoo.

Siv ua ke nrog cov tshuaj insulin

Hauv cov neeg mob uas tsis muaj peev xwm tswj tau tus mob ntshav qab zib mellitus, insulin tuaj yeem muab rau tib lub sijhawm thaum noj ntau tshaj plaws txhua hnub ntawm glimepiride. Hauv qhov no, koob tshuaj kawg ntawm glimepiride qhia rau tus neeg mob tseem tsis hloov pauv. Hauv qhov no, kev kho tshuaj insulin pib nrog kev siv tshuaj tsawg, uas maj mam nce ntxiv ntawm kev tswj hwm qhov kev tswj hwm ntawm cov piam thaj hauv cov ntshav. Kev kho mob sib xyaw ua ke yuav tsum muaj kev saib xyuas mob nkeeg.

Siv rau hauv cov neeg mob lub raum tsis ua haujlwm

Nws muaj tsawg cov ntaub ntawv ntawm kev siv cov diamerid hauv cov neeg mob uas lub raum tsis ua haujlwm. Cov neeg mob ua rau lub raum tsis zoo ua haujlwm yuav ua rau nkag siab qhov teebmeem hypoglycemic ntawm glimepiride.

Siv rau hauv cov neeg mob mob siab tsis ua haujlwm

Muaj tsawg cov lus qhia ntawm kev siv cov tshuaj rau daim siab ua haujlwm.

Siv rau menyuam yaus

Cov ntaub ntawv hais txog kev siv hauv cov menyuam yaus yog tsis txaus.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj muaj nyob rau hauv cov ntsiav tshuaj. Cov duab ntawm cov ntsiav tshuaj yog ib lub tiaj tus kheej kheej nrog bevel. Xim nyob ntawm tus nqi ntawm cov nquag siv hauv cov ntsiav tshuaj; nws yuav daj lossis liab dawb.

Cov ntsiav tshuaj tuaj yeem ntim tshuaj 1, 2, 3 mg lossis 4 mg ntawm cov tshuaj nquag nquag.

Cov kev zam yog: lactose monohydrate, magnesium stearate, povidone, microcrystalline cellulose, poloxamer, croscarmellose sodium, zas xim.

Ib pob muaj 3 lub hlwv, txhua tus 10 pcs.

Pharmacological kev txiav txim

Cov tshuaj no muaj cov nyhuv hypoglycemic. Qhov kev txiav txim ntawm cov tshuaj yog ua raws li kev tsim tawm cov tshuaj insulin los ntawm beta hlwb ntawm cov leeg ntawm pancreatic islets ntawm Langerhans, ntxiv rau nce qhov kev nkag siab ntawm cov nqaij mos tau txais rau cov tshuaj hormones thiab ua kom cov ntshav qabzib hloov cov protein ntau hauv cov ntshav. Ua raws li cov ntaub so ntswg, cov tshuaj ua rau nws lub depolarization thiab qhib kev tiv thaiv kev tiv thaiv kab mob calcium raws, vim qhov twg ua rau ntawm tes tshwm sim.

Nws txo tus nqi ntawm gluconeogenesis nyob rau hauv daim siab vim yog qhov txhaws ntawm cov enzymes tseem ceeb, yog li muaj cov nyhuv hauv lub cev tsis tseem ceeb.

Cov tshuaj muaj cov nyhuv hauv platelet kev sib sau, txo nws. Nws inhibits cyclooxygenase, thaiv qhov oxidation ntawm arachidonic acid, muaj cov tshuaj antioxidant, txo tus nqi ntawm lipid peroxidation.

Cov Tshuaj Pharmacokinetics

Nrog kev siv tsis tu ncua, ntawm 4 mg ib hnub twg, qhov ntau tshaj plaws ntawm cov tshuaj hauv cov ntshav pom 2-3 teev tom qab kev tswj hwm. Txog li 99% ntawm cov khoom sib txuas rau cov protein ntau.

Ib nrab-lub neej yog 5-8 teev, cov tshuaj yog tawm hauv daim ntawv metabolized, tsis nthuav tawm hauv lub cev. Dhau los ntawm tus me nyuam thiab hla mus rau hauv niam mis.

Yuav ua li cas noj diamerid?

Thaum noj cov tshuaj, tus kws kho mob yuav tsum soj ntsuam cov qib ntawm cov piam thaj hauv cov ntshav kom xwm yeem. Tus kws kho mob tshwj xeeb txiav txim siab qhov concentration ntawm cov piam thaj hauv cov ntshav, uas yuav tsum yog tom qab noj cov tshuaj. Qhov siv koob tshuaj tsawg tshaj plaws, uas cov nyhuv tsim nyog tuaj yeem ua tiav.

Cov tshuaj muaj nyob rau hauv cov ntsiav tshuaj. Cov duab ntawm cov ntsiav tshuaj yog ib lub tiaj tus kheej kheej nrog bevel.

Nrog ntshav qab zib

Thawj koob tshuaj yog 1 mg rau ib hnub. Nrog lub sijhawm ntawm 1-2 lub lis piam, kws kho mob nce qhov ntau ntxiv, xaiv qhov tsim nyog. Koj koj tus kheej tsis tuaj yeem, yam tsis tau sab laj nrog kws kho mob, pib noj tshuaj lossis hloov qhov hloov pauv, vim tias nws yog tus neeg sawv cev zoo kho, kev siv tsis raug ntawm cov uas yuav muaj qhov tsis zoo.

Nrog rau cov ntshav qab zib kom tau txais txiaj ntsig zoo, qhov tshuaj ntawm cov tshuaj ib hnub yog 1-4 mg, ntau dua qhov tau ntau yog tsis tshua siv vim qhov tseeb tias lawv ua rau cov neeg tsawg tsawg xwb.

Tom qab noj cov tshuaj, koj yuav tsum tsis txhob hla ib pluas noj, uas yuav tsum tau ntom. Cov kev kho mob ntev.

Siv tshuaj diameride pom zoo rau cov mob ntshav qab zib hom 2, yog tias kev kho mob nrog kev noj zaub mov kom tsawg thiab ua kom lub cev tsis muaj qhov ua kom zoo.

Cuam tshuam rau lub peev xwm los tswj cov tshuab

Cov tshuaj muaj feem cuam tshuam rau kev muaj peev xwm los tswj cov tswv yim vim yog kev txhim kho ntawm lub qog ntshav qab zib, uas nrog nrog kev poob qis hauv lub cev, tas mus li nkees thiab qaug zog. Lub peev xwm los ua haujlwm uas yuav tsum muaj kev saib xyuas tas li, suav nrog kev tsav tsheb, txo qis.

Siv rau lub sijhawm qub

Hauv lub hnub nyoog laus, tus neeg feem ntau tsis tuaj yeem qhib kev sib txuas lus nrog nws tus kws kho mob, vim tias tus kws kho mob tsis tuaj yeem paub tus neeg mob tus mob tom qab noj cov tshuaj thiab kho qhov tshuaj, uas cuam tshuam rau kev ua tau zoo ntawm kev kho thiab tus neeg mob tus mob. Yog li, tus neeg mob yuav tsum qhia tus kws kho mob txhua lub sijhawm txog kev hloov pauv hauv lub xeev, paub tias qhov no tsim nyog ua ntej ntawm nws tus kheej.

Siv thaum cev xeeb tub thiab lactation

Thaum cev xeeb tub thiab thaum pub niam mis, cov tshuaj yog contraindicated vim tias nws muaj peev xwm nkag mus rau hauv qhov chaw ntawm lub plab thiab tso rau hauv cov kua mis, uas tuaj yeem ua mob rau tus menyuam lub cev tsis zoo. Yog li, tus poj niam uas tau noj cov tshuaj no ua ntej xeeb tub yog hloov mus rau kev kho mob insulin.

Thaum cev xeeb tub thiab thaum pub niam mis, cov tshuaj yog contraindicated

Ntau tshaj ntawm diamerid

Yog tias dhau ntawm kev noj haus ntau dhau, qhov kev tiv thaiv ntshav qab zib yog pom, uas yog nrog mob taub hau, zoo li tsis muaj zog, tawm hws, tachycardia, muaj kev paub ntshai thiab ntxhov siab. Yog tias cov tsos mob no tshwm sim, koj yuav tsum tau noj cov zaub mov sai sai, piv txwv li, noj ib qho qab zib. Thaum muaj mob ntau dhau ntawm cov tshuaj, nws yog ib qho tsim nyog los ntxuav lub plab lossis ua rau ntuav. Txog rau thaum lub xeev ruaj khov tiav, tus neeg mob yuav tsum nyob hauv kev saib xyuas kev kho mob, yog li thaum muaj cov suab thaj tsawg dua, tus kws kho mob tuaj yeem pab tau.

Kev cuam tshuam nrog lwm yam tshuaj

Thaum siv cov tshuaj nrog lwm cov tshuaj, nws tuaj yeem ua kom tsis muaj zog lossis ntxiv dag zog rau nws txoj haujlwm, nrog rau kev hloov pauv ntawm lwm yam tshuaj, yog li nws tseem ceeb qhia rau tus kws kho mob txog cov tshuaj uas siv. Piv txwv li:

1. Nrog rau kev tswj hwm tib lub sijhawm ntawm glimepiride thiab insulin, lwm yam kab mob hypoglycemic, coumarin derivatives, glucocorticoids, metformin, cov tshuaj hormones pw ua ke, angiotensin-hloov mus rau enzyme inhibitors, fluoxetine, thiab lwm yam, cov ntshav qab zib tsawg tuaj yeem tsim kho.
2. Glimepiride tuaj yeem tiv thaiv lossis txhim kho cov nyhuv ntawm coumarin derivatives - cov tshuaj tiv thaiv kab mob.
3. Barbiturates, laxatives, T3, T4, glucagon tuaj yeem ua kom tsis muaj zog ntawm cov tshuaj, txo cov txiaj ntsig ntawm kev kho mob.
4. H2 histamine receptor blockers tuaj yeem hloov kho qhov cuam tshuam ntawm glimepiride.

Nrog rau kev tswj hwm tib lub sijhawm ntawm glimepiride thiab insulin, lwm yam kab mob hypoglycemic, kev txhim kho cov ntshav khov ntau yog ua tau.

Cawv tau zoo

Kev haus cawv ib zaug lossis nws siv tsis tu ncua tuaj yeem hloov qhov kev ua yeeb yam ntawm cov tshuaj, nce ntxiv lossis txo qis.

Cov tshuaj Analogues yog cov neeg sawv cev uas muaj cov glimepiride ua cov tshuaj nquag. Cov no yog cov tshuaj xws li:

1. Amaril. Nov yog tshuaj German, txhua ntsiav tshuaj ntawm muaj ib koob tshuaj 1, 2, 3 lossis 4 mg. Ntau lawm: Lub teb chaws Yelemees.
2. Glimepiride Canon, Muaj cov koob tshuaj 2 lossis 4 mg. Qhuav: Russia.
3. Glimepiride Teva. Muaj nyob rau hauv cov koob tshuaj 1, 2 lossis 3 mg. Ntau lawm: Croatia

Diabeton yog ib qho tshuaj tiv thaiv hypoglycemic, muaj tib yam hypoglycemic zoo, tab sis nws cov tshuaj nquag yog qhov khoom noj ntawm sulfonylurea ntawm lub cim thib ob.

Amaryl yog ib qho duab ntawm Diamerid. Nov yog tshuaj German, txhua ntsiav tshuaj ntawm muaj ib koob tshuaj 1, 2, 3 lossis 4 mg.

Kev tshuaj xyuas rau Diamerida

Ua ntej siv cov tshuaj, koj yuav tsum tau txais kev paub nrog kev txheeb xyuas txog nws.

Starichenko V. K .: "Cov tshuaj no yog cov txiaj ntsig zoo rau kev tshem tawm cov ntshav qab zib hom 2. Nws raug tso cai siv nws nrog insulin lossis ua kev kho mob monotherapy. Tsuas yog tus kws kho mob tuaj yeem sau thiab kho lub koob tshuaj."

Vasilyeva O. S .: "Cov tshuaj yuav txo cov ntshav qabzib hauv cov ntshav, tiv thaiv qhov tsis zoo ntawm ntshav qab zib. Tsuas yog tus kws tshaj lij yuav tsum sau cia txoj kev kho thiab txiav txim siab txog kev kho mob."

Galina: "Cov ntshav qab zib cov ntshav nce siab zuj zus, ib yam tshuaj uas muaj cov tshuaj glimepiride tau raug sau tseg. Cov ntsiav tshuaj zoo xis, nqos zoo, noj txhua txhua hnub ua ntej noj tshais.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv ua ke ntawm Diameride nrog rau qee cov tshuaj / tshuaj, cov teebmeem hauv qab no tuaj yeem tsim tawm (cov lus qhia kho mob ua ntej yuav tsum tau sau ib qho yeeb tshuaj):

• acetazolamide, barbiturates, glucocorticosteroids, diazoxide, saluretics, thiazide diuretics, epinephrine thiab lwm yam tshuaj sympathomimetic, glucagon, laxatives (nrog rau siv ntev), nicotinic acid derivatives, nicotinic acid (hauv siab), estrogens, progestogens, chlorotazine derivatives, phenotinic acid, phenotinic , phenytoin, rifampicin, cov thyroid hormones, cov roj ntsha lithium: cov roj ntsha hauv lub cev tsis muaj zog thiab, yog li ntawd, nce qhov kev nce siab ntawm cov piam thaj hauv ntshav,
• insulin, Metformin los yog lwm yam ncauj hypoglycemic neeg sawv cev, angiotensin converting enzyme inhibitors, allopurinol, anabolic steroids thiab txiv neej nrog txiv neej pw cov tshuaj hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, trofosfamide thiab ifosfamide fenfluramine, fibrates, fluoxetine, sympatholytic (guanethidine), monoamine oxidase inhibitors, miconazole, pentoxifylline (nrog rau cov kev tswj hwm hauv tsoomfwv qib siab), phenylbutazone, azapropazone, oxyphenbutazone, probenecid, tshuaj tua kab mob quinolone, salicylates thiab aminosalicylic acid, s Ulfinpyrazones, qee qhov ua haujlwm ntev ntev sulfonamides, tetracyclines, tritokvalin, fluconazole: muaj cov nyhuv hypoglycemic ntau dua thiab, vim yog li ntawd, qhov zoo li yuav ua rau muaj ntshav qab zib tsawg,
• reserpine, clonidine, N blockers₂-histamine receptors: potentiation / ua kom lub zog ntawm hypoglycemic kev txiav txim siab ntawm diamerid,
• tshuaj uas inhibit pob txha hlwb hematopoiesis: kev nce ntxiv ntawm cov mob ntawm myelosuppression,
• cov lus qhia txuas ntxiv: ntxiv dag zog / txhawb lawv lub luag haujlwm,
• beta-blockers, clonidine, reserpine, guanethidine: ua kom tsis muaj zog lossis tsis muaj kev kho mob hauv kev kho tus mob hypoglycemia,
• cawv (ntev / siv ib qho): nce / tsis muaj zog hypoglycemic kev txiav txim siab ntawm diamerid.

Cov Lus Cim ntawm Diameride yog: Glimepiride, Amaryl, Glemauno, Glime, Glemaz, Meglimid, Glymedeks thiab lwm yam.

Cev xeeb tub thiab lactation

Glimepiride yog sib kis thaum cev xeeb tub. Kev xeeb menyuam hauv plab lossis thaum pib cev xeeb tub, tus pojniam yuav tsum pauv mus rau kev kho mob insulin.

Vim hais tias Txij li thaum glimepiride raug tawm hauv cov kua mis, nws yuav tsum tsis txhob muab tshuaj rau lub sijhawm lactation. Hauv qhov no, nws yog ib qho tsim nyog yuav tsum hloov mus rau kev siv tshuaj insulin lossis txwv kom tsis pub niam mis.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Kev noj tshuaj ntawm glimepiride hauv cov ntsiav tshuaj no yuav txawv: 1, 2, 3 lossis 4 mg. Txuas ntxiv, cov hauv qab no suav nrog:

• microcrystalline cellulose,
• magnesium stearate,
• croscarmellose sodium,
• hmoov cellulose,
• dyes.

Cov no yog tiaj tiaj, duab plaub ntsiav tshuaj, ntim hauv ib lub hlwv (3 lossis 6) ntawm 5 lossis 10 daim.

Cov lus qhia rau kev siv

Qhov ntau npaum li cas yog muab los ntawm tus kws kho mob tshwj xeeb raws li cov ntaub ntawv ntawm cov tshuaj ntsuam tau thiab cov tib neeg xav tau ntawm lub cev.

Nws yuav tsum noj rau ntawm lub plab khoob, ua ntej noj mov, haus dej ntau thiab tsis zom. Qhov tshuaj thawj zaug yog 1 mg ib hnub ib zaug. Ntxiv mus, tom qab 1-2 lub lis piam, nws tuaj yeem ua kom ntau zog. Qhov siab tshuaj ntau tshaj txhua hnub yog 6 mg.

Piv nrog analogues

Muaj ntau tus yeeb tshuaj zoo ib yam li cov tshuaj tau piav. Nws yuav muaj txiaj ntsig zoo los paub koj tus kheej nrog lawv lub zog thiab piv cov kev ua.

Lawj Xeeb MV. Cov no yog cov ntsiav tshuaj uas muaj gliclazide. Ua cov tuam txhab "Servier", Fabkis. Tus nqi ntawm kev ntim khoom yog 300 rubles thiab tshaj saud. Qhov no yog qhov zoo nkauj tshaj plaws hauv cov khoom. Cov txheej txheem sib dhos yog tus qauv, tsis pom zoo rau cov laus.

Amaril. Tus nqi yog ntawm 300 txog 1000 rubles rau pob khoom (30 daim). Tuam txhab tsim khoom - Sanofi Aventis, Fabkis. Qhov no yog cov khoom sib txuam ua ke raws li glimepiride thiab metformin. Ua tsaug rau kev sib xyaw ua ke ntawm nws cov dej num nws ua tau sai dua thiab kev taw qhia ntau dua. Cov txheej txheem sib dhos yog tus qauv, muaj ntau cov kev mob tshwm sim.

NovoNorm. Ib yam tshuaj uas muaj cov tshuaj repaglinide. Muaj peb hom kev tso tawm, nyob ntawm seb qhov kev faib tawm ntawm cov tshuaj nquag. Tus nqi pib ntawm 180 rubles rau ib pob. Cov neeg tsim khoom - "Novo Nordisk", Denmark. Qhov no yog cov khoom siv pheej yig, muaj txiaj ntsig zoo, tab sis muaj tus lej ntawm cov contraindications. Tsis haum rau menyuam yaus, cov neeg laus thiab cov pojniam xeeb tub.

Glimepiride. Nqe - los ntawm 140 txog 390 rubles. Cov tuam txhab tshuaj hauv tuam txhab Pharmstandard, kuj tsim los ntawm cov tuam txhab Lavxias teb sab Vertex. Lub ntsiab tivthaiv yog glimepiride. Muaj tsib daim ntawv ntawm kev ua lag luam nrog cov ntsiab lus sib txawv ntawm cov tshuaj nquag. Nws muaj cov nyhuv zoo sib xws, cov lus contraindications yog qhov qub. Siv nrog ceev faj rau cov neeg laus.

Maninil. Cov tshuaj muaj glibenclamide. Cov khoom lag luam tsim lub tuam txhab "Berlin Chemie", lub teb chaws Yelemees. Tus nqi qis - 120 rubles rau 120 ntsiav tshuaj. Qhov no yog qhov pheej yig tshaj plaws analogue, ob qho tib si hais txog cov khoom thiab muaj. Zoo sib xws contraindications.

Tus kws kho mob txiav txim siab qhov twg yog qhov zoo tshaj plaws rau tus neeg mob thiab hloov mus rau lwm yam tshuaj. Kev siv tus kheej yog txwv!

Kev xav ntawm cov ntshav qab zib nrog kev paub ntawm cov tshuaj feem ntau yog qhov zoo. Cov neeg nco ntsoov qhov ua tau zoo ntawm cov tshuaj, tsawg tsawg ntawm cov kev phiv. Rau qee qhov, twj tsis haum.

Olga: “Kuv tau kho tus mob ntshav qab zib tau ntev. Kuv tau sim tshuaj ntau, tam sim no kuv nres ntawm Diamerida. Kuv siv nrog kev sib xyaw nrog Metformin, Kuv nyiam cov nyhuv ntawm cov tshuaj. Qab zib yog qhov qub, tsis txhob txhawj "phiv". Thiab qhov tseem ceeb tshaj plaws, nws yog muag dawb hauv khw muag tshuaj. "

Daria: “Kuv noj cov tshuaj Diameride tau ob lub hlis, qib suab thaj tsis hloov. Tus kws kho mob tau hais tias nws tsis tsim nyog rau kuv kis, thiab kws kho mob ntxiv. "

Oleg: “Tus kws kho mob tau sau ntawv rau kuv cov tshuaj no rau lub hlis dhau los. Tus mob tau ruaj khov lawm. Kev hloov ua suab thaj tsis txhob txhawj xeeb; kev noj qab haus huv tag nrho yog qhov zoo.Nws yog qhov zoo uas qhov no yog tshuaj ntawm kev tsim khoom hauv tsev, uas nyob hauv nws lub zog thiab zoo tsis muaj qhov phem dua li cov neeg txawv teb chaws. Thiab vim li cas ho them nyiaj ntau dua yog tias muaj txoj hauv kev los kho mob pheej yig dua nrog tib cov nyhuv thiab zoo dua. "

Elena: “Kuv muaj ntshav qab zib hom 2. Tsuas yog kev noj haus tau tsum tsis pab, yog li cov kws tsim tshuaj txog kabmob endocrinologist tau taw qhia Diamerid, hais tias nws yog Lavxias kev tsim khoom, ntawm kev tsim nyog. Thiab kuv tau kho nws tau peb lub hlis tam sim no. Nws yooj yim heev uas koj noj ib ntsiav tshuaj ib hnub, thiab cov nyhuv no ntev. Qab zib tsis hla, hypoglycemia tsis tshwm sim, uas tshwj xeeb tshaj yog thov. Kuv tseem yuav saib xyuas nws mus ntxiv. "

Xaus

Txiav txim los ntawm kev txheeb xyuas thiab piav qhia txog lub zog ntawm cov tshuaj, nws zoo heev. Nws yog sau tseg tias tus nqi-zoo piv yog raug hwm, thiab kev tsim khoom hauv tsev tsis yog rho tawm ntawm cov tshuaj. Cov neeg mob ntshav qab zib, nrog rau cov kws tshaj lij, nco ntsoov tias Diamerid ua tau zoo rau ob qho tib si hauv kev kho tshuaj thiab nrog lwm cov tshuaj.

Cov lus thiab cov xwm txheej ntawm kev cia

Cov tshuaj yuav tsum muab cia tawm ntawm qhov chaw ncav cuag ntawm cov menyuam yaus, qhuav, tiv thaiv los ntawm lub teeb, hauv qhov chaw ntawm qhov kub tsis tshaj 25 ° C. Txee lub neej yog 2 xyoos.

- Hom 2 mob ntshav qab zib mellitus nrog qhov tsis muaj txiaj ntsig ntawm kev noj cov zaub mov yav dhau los thiab kev siv lub cev.

Yog tias monotherapy nrog glimepiride ua haujlwm tsis muaj txiaj ntsig, nws tuaj yeem raug siv los ua ib feem ntawm kev sib xyaw ua ke nrog metformin lossis insulin.