Yuav Siv Li Cas Levemir Penfill Kev daws
Levemir Penfill
1 ml ntawm cov tshuaj Levemir Penfill muaj:
Insulin detemir - 100 PIECES.
Cov kev zam: metacresol, phenol, mannitol, sodium dihydrogen phosphate disodium, zinc acetate, sodium chloride, sodium hydroxide, hydrochloric acid, dej rau kev txhaj tshuaj.
1 ntu ntawm insulin detemir sib raug rau 0.142 mg ntawm anhydrous desalted insulin detemir. Cov UNITS ntawm cov tshuaj nquag ntawm cov tshuaj yog zoo ib yam rau ME ntawm tib neeg cov tshuaj insulin.
Pharmacological kev txiav txim
Levemir Penfill yog ib qho tshuaj tua kab mob tiv thaiv kab mob. Levemir Penfill yog cov tshuaj ua kom sib xyaw ntawm tib neeg cov roj ntsha insulin nrog cov nyhuv ntev mus. Levemir Penfill tsis tau pom los ntawm lub ncov tseem ceeb hauv kev ua si.
Hauv kev sim tshuaj, qhov twv ua ntej ntawm cov nyhuv ntawm Levemir Penfill daws tau siab dua li ntawm cov tshuaj insulin glargine thiab cov tshuaj tiv thaiv nruab nrab-insulin Hagedorn.
Cov txiaj ntsig ntev ntev ntawm cov tshuaj yog vim muaj qhov sib txuas tseem ceeb ntawm cov molecules ntawm cov tshuaj nquag, ntxiv rau ntxiv rau ntawm albumin rau lawv los ntawm ib sab txuas ntawm cov roj ntsha ntawm qhov chaw txhaj tshuaj. Muab piv rau cov tshuaj nruab nrab ntawm cov tshuaj tiv thaiv-insulin Hagedorn, cov tshuaj ua kom nquag ntawm Levemir Penfill daws tau muab faib ntau qeeb dua hauv cov nqaij mos. Ua tsaug rau cov txheej txheem no, lub sijhawm thiab qhov hnyav ntawm qhov kev txiav txim ntawm insulin detemir yog qhov paub tau ua ntej.
Cov nyhuv hypoglycemic ntawm Levemir Penfill daws yog txuam nrog kev nce ntxiv ntawm cov piam thaj los ntawm cov leeg nqaij thiab adipose cov nqaij tom qab khi ntawm cov receptors tshwj xeeb rau insulin, nrog rau kev txo qis tawm ntawm cov kua nplaum los ntawm lub siab.
Qhov ua rau lub ntsej muag ntshav ntawm Levemir Penfill daws yuav kav ntev txog 24 teev thiab yuav txawv nyob ntawm qhov siv tshuaj. Vim tias lub sijhawm ua haujlwm ntev, cov neeg mob tuaj yeem siv cov tshuaj Levemir Penfill 1 lossis 2 zaug ib hnub. Thaum siv cov tshuaj ob zaug ib hnub, kev txhim kho glycemic yog sau tom qab 2-3 hno. Nws tau sau tseg tias ntau tshaj 50% ntawm cov txiaj ntsig tshaj plaws ntawm detemir insulin yog ua tiav tau los ntawm 3-4 teev tom qab kev tswj hwm ntawm 0.2-0.4 U / kg ntawm tus neeg mob lub cev (lub sijhawm ntawm cov lus tawm hypoglycemic nyhuv tom qab tswj hwm ntawm cov tshuaj no yog 14 teev).
Tom qab qhia txog ntawm Levemir Penfill daws, qhov tawm ntawm qhov koob tshuaj, qhov siab tshaj plaws thiab tag nrho cov txiaj ntsig, nrog rau lub sijhawm ntawm cov nyhuv hypoglycemic tau sau tseg subcutaneously.
Lub sijhawm kawm 6 lub hlis ntawm Levemir Penfill daws nyob rau cov neeg mob ntshav qab zib hom 1 mob ntshav qab zib, tau muaj kev tiv thaiv zoo glycemic nrog tsawg tshaj tawm cov lus sib txawv hauv cov ntshav qabzib (tom qab stimulation thiab basal) piv nrog kev siv rau basal-bolus kho ntawm NPH.
Cov kev tshawb fawb nthuav tawm qhov tsis muaj ntawm cov nyhuv ntawm insulin detemir rau tus neeg mob lub cev qhov hnyav. Qhov kev txo qis hauv cov kev pheej hmoo ntawm nocturnal hypoglycemia hauv cov neeg mob uas tau txais detemir ua kev kho pob ntseg ntawm pob ntseg ntawm insulin yog piav qhia.
Peak insulin theem ntawm detemir tau kaw nyob rau hauv cov ntshav dej 6-8 teev tom qab subcutaneous kev tswj hwm ntawm Levemir Penfill daws. Qeb sib luag nrog cov kev kho tas li (tswj hwm ntawm cov tshuaj ob zaug ib hnub) tau tiav tom qab 2-3 koob. Piv nrog rau lwm cov kev npaj tshuaj insulin, Levemir Penfill tsis tshua muaj qhov txawv txav ntawm qhov muaj zog hauv kev nqus tawm tom qab kev tswj hwm.
Qhov nruab nrab faib qhov ntau ntawm cov tshuaj (kwv yees li 0.1 l / kg) qhia txog qhov kev hloov pauv tseem ceeb ntawm cov tshuaj nquag hauv lub txaj vascular.
Detemir insulin metabolism zoo ib yam li cov insulin endogenous. Derivatives ntawm cov tshuaj tsis muaj hypoglycemic kev ua si.
Hauv vivo thiab kev tshawb fawb hauv vitro, tsis muaj qhov tseem ceeb ntawm kev sib txuam pharmacokinetic ntawm insulin detemir nrog cov roj ntsha thiab lwm yam tshuaj muaj protein.
Kev tshem tawm cov insulin detemir kav ntev txog 5-7 teev thiab nyob ntawm tus neeg qhov nqus nqus dej thiab cov koob tshuaj tau muab rau.
Tom qab tswjhwm subcutaneous, cov tshuaj insulin ntau ntau ntawm cov tshuaj tiv thaiv yog muaj xwm yeem raws li cov koob tshuaj tau muab.
Cov kev tshawb fawb tsis qhia tawm kev hloov pauv ntawm daim ntawv kho keeb kwm ntawm kev ua haujlwm Levemir Penfill nyob ntawm tus tub los ntxhais thiab hnub nyoog (kev tshawb fawb hauv cov neeg mob ntawm ntau pawg hnub nyoog, suav nrog 6-12 xyoo, 13-17 xyoo thiab cov laus pom tias tsis muaj qhov txawv txawv ntawm txawv txawv txawv).
Tsis muaj ib qho kev hloov pauv tseem ceeb nyob rau hauv profile pharmacokinetic kho mob ntawm Levemir Penfill hauv cov neeg tuaj yeem noj qab haus huv thiab cov neeg mob lub cev tsis zoo.
Tsis muaj teratogenic, carcinogenic thiab fetotoxic cov teebmeem ntawm Levemir Penfill daws tau pom.
Txoj kev ntawm daim ntawv thov
Kev daws ntawm Levemir Penfill yog npaj rau kev tswj hwm subcutaneous. Lub sijhawm tseem ceeb ntawm kev nqis tes ua, cov haujlwm xav tau qhov tseeb thiab muaj kev pheej hmoo tsawg ntawm nocturnal hypoglycemia ua rau nws tuaj yeem xaiv qhov tseeb ntawm cov koob tshuaj ntawm cov tshuaj nquag ntawm Levemir Penfill daws.
Nws yog ib qho tsim nyog yuav tau xaiv txoj kev txhaj tshuaj ntawm Levemir Penfill kev daws teeb meem rau txhua tus neeg mob. Cov koob tshuaj uas xaiv tau tuaj yeem siv tau 1 lossis 2 zaug nyob ntawm seb qhov xav tau ntawm txhua tus neeg mob. Yog tias tus kws kho mob tshwj xeeb pom zoo kom muab ob zaug kev tswj hwm ntawm cov tshuaj Levemir Penfil, koob tshuaj thib ob yuav tsum tau muab rau noj ua ntej noj hmo lossis ua ntej mus pw lossis 12 teev tom qab noj tshuaj tag.
Hloov ntawm ntau cov tshuaj insulin npaj rau Levemir Penfill tov
Cov neeg mob uas yav dhau los siv insulins nruab nrab lossis ntev ntev cov insulins yuav tsum tau ua tib zoo saib xyuas Levemir Penfill. Thaum lub sij hawm hloov los ntawm ib qho tshuaj insulin mus rau lwm tus, koj yuav tsum ua tib zoo saib xyuas qib ntshav qab zib hauv ntshav dej.
Nrog cov kev kho mob nyuaj tiv thaiv keeb kwm yav dhau los ntawm kev hloov pauv ntawm cov tshuaj insulin ntawm lub sijhawm ntev, kev hloov kho koob tshuaj thiab kev tswj hwm tshuaj ntawm cov tshuaj insulin muaj kev txiav txim luv lossis hypoglycemic rau kev tswj hwm qhov ncauj yuav tsim nyog.
Xaiv cov koob tshuaj ntawm Levemir Penfill daws
Cov neeg laus thiab cov neeg muaj lub siab thiab lub raum tsis ua haujlwm yuav tsum ua tib zoo saib kom paub cov ntshav qabzib hauv lub sijhawm xaiv koob (zoo li lwm yam insulins).
Qhov yuav tsum tau hloov qhov kev txhaj tshuaj ntawm Levemir Penfill yuav tshwm sim thaum muaj kev ua haujlwm hauv lub cev ntau ntxiv, nrog rau cov kev hloov hauv kev noj zaub mov noj lossis qhov tshwm sim / exacerbation ntawm concomitant kab mob.
Cov lus qhia ntawm Levemir Penfill daws
Kev daws ntawm Levemir Penfill yog muab rau subcutaneously. Nws raug nquahu kom muab cov tshuaj mus rau sab xub ntiag ntawm lub plab phab ntsa, xub pwg lossis ncej puab. Nws raug nquahu kom hloov chaw txhaj tshuaj ntawm txhua qhov kev txhaj tshuaj.
Levemir Penfill cartridges yog tsim los siv nrog Novo Nordisk koob txhaj tshuaj nrog NovoFine koob. Levemir Penfill daim cartridges tsuas yog siv rau tus kheej nkaus xwb, txwv tsis pub daim cartridge txwv. Thaum kho nrog Levemir Penfill thiab lwm yam tshuaj insulin hauv Penfill cartridge, cais tus cwj mem kua rau txhua cov tshuaj yuav tsum tau siv.
Ua ntej pib kev tswj hwm ntawm Levemir Penfill daws, nws yog ib qho tseem ceeb kom paub tseeb tias cov tshuaj insulin uas raug xaiv lawm, tsis muaj qhov pom kev puas tsuaj rau daim cartridge lossis roj hmab piston. Nws yog txwv tsis pub siv cov kev daws teeb meem los ntawm cov roj cartridges, zoo li yog tias pom qhov seem ntawm cov roj hmab piston tshaj qhov dav ntawm cov kab txaij dawb. Ua ntej siv lub Levemir Penfill lub taub hau, cov roj hmab cov roj hmab yuav tsum tau muab tshuaj tua kab mob nrog ib qho tshuaj tua kab mob kom haum rau kev kho qhov chaw txhaj tshuaj (piv txwv, ethyl cawv).
Nws yog txwv tsis pub siv yeeb tshuaj Levemir Penfill:
- Hauv cov tshuaj insulin.
- Thaum tsis zoo ntim, nrog rau tom qab khov.
- Yog tias muaj qhov tshwm sim ntawm kev puas tsuaj rau lub cartridge (suav nrog yog tias tus xaum xoob poob lossis lub laub dej succumbed rau sab nraud siab).
- Thaum cov xim lossis pob tshab ntawm cov kev hloov pauv.
Cov tshuaj Levemir Penfill tau muab tswj hwm raws li cov lus qhia rau kev xaum ua haujlwm. Nws yuav tsum tau yug los rau hauv lub siab tias rau kev qhia ntawm tag nrho cov koob tshuaj tom qab ua tiav ntawm kev txhaj tshuaj, lub koob yuav tsum tawm hauv qab daim tawv nqaij 6-10 vib nas this. Cov koob yuav tsum tau muab rho tawm ntawm lub koob txhaj tshuaj tam sim ntawd tom qab txhua qhov kev txhaj tshuaj (txhawm rau kom tsis txhob xau ntawm insulin).
Sab sij huam
Feem ntau ntawm qhov xwm txheej tsis zoo sau cia thaum kho nrog Levemir Penfill daws yog cuam tshuam nrog kev txhaj tshuaj ntawm detemir insulin thiab yog qhov kev cia siab ntawm nws txoj kev ua pharmacological.
Feem ntau feem ntau, hypoglycemia cuam tshuam nrog qhov tseem ceeb ntawm cov tshuaj tau muab sau tseg thaum kho. Hauv kev sim tshuaj, kev mob ntshav qog ntshav ntshav siab heev uas xav tau kev kho mob tsim los hauv 6% ntawm cov neeg mob tau txais Levemir Penfill. Nws yog ib qho tsim nyog yuav tsum tau ua tib zoo xaiv cov koob tshuaj insulin, vim tias qhov mob ntshav qab zib tsawg kawg tuaj yeem ua rau tsis nco qab, qaug dab peg, nrog rau ib ntus lossis ib ntus tsis zoo rau lub hlwb kev ua haujlwm. Qee qhov xwm txheej, mob ntshav qab zib siab hnyav tuaj yeem ua rau neeg tuag taus.
Qee qhov xwm txheej, thaum txhaj cov tshuaj Levemir Penfill, cov kev mob tshwm sim hauv zej zog tau sau tseg tom qab kev tswj hwm, tshwj xeeb hyperemia, mob caj dab, thiab nqaij o nqaij (hauv kev tshawb nrhiav, qhov tshuaj tiv thaiv tau pom hauv 2% ntawm cov neeg mob). Cov kev tawm tsam hauv zos feem ntau tau ua rau lawv tus kheej thiab tsis xav tau kev kho mob.
Hauv cov kev tshawb fawb soj ntsuam, cov kev tshwm sim tsis zoo no ntawm Levemir Penfill daws kuj tau sau tseg:
- Kev tiv thaiv kab mob: hypoglycemia (suav nrog cov tsos mob xws li pallor, hws khaub thuas, tshee tshee, tshee tshee, ntxhov siab, tsis muaj zog, chim siab, tsis hnov qab, nkees nkees, tsis meej pem, mob plab, tachycardia, xeev siab, mob taub hau, pom ib ntus, kev tshaib kev nqhis). Hauv qee qhov tsis tshua muaj tshwm sim, muaj ntshav nce siab ntau ntau raug sau tseg, ua rau tsis nco qab, tsis meej pem, ua haujlwm tsis zoo hauv lub hlwb.
- Cov tshuaj tiv thaiv hauv zos: cov nqaij ntshiv edema, khaus khaus, tawm ntawm daim tawv nqaij, lipodystrophy (feem ntau yog qhia nrog txhua qhov tshuaj nyob hauv tib thaj chaw).
- Hypersensitivity: hyperhidrosis, feem ntau pruritus, Quincke's edema, ua tsis taus pa, anaphylactic ceeb.
- Cov plab hnyuv siab raum: tsis pom pom tseeb, rov ua qhov yuam kev.
Nws yuav tsum tau yug hauv siab tias qhov kev xav tsis haum yog qhov tsis zoo rau tus neeg mob lub neej. Nrog rau kev txhim kho ntawm thawj cov tsos mob ntawm qhov tsis nco qab, tus neeg mob yuav tsum nrhiav kev kho mob sai.
Hauv cov neeg mob ntshav qab zib, mob ntshav qab zib retinopathy yuav tshwm sim nrog kev tswj tsis tau glycemic. Cov nyhuv no tsis ncaj qha ntsig txog kev siv tshuaj Levemir Penfill, txawm li cas los xij, kev xaiv koob tshuaj tsis raug tuaj yeem ua rau exacerbation thiab kev hloov kho ntawm tus mob hlwb.
Hauv qee cov neeg mob uas muaj mob neippathy, nrog kev txhim kho sai ntawm glycemic tswj, daim ntawv thim rov qab uas mob hnyav tuaj yeem tshwm sim.
Cev xeeb tub
Nws muaj tsawg qhov kev paub nrog kev siv cov insulin detemir hauv cov poj niam cev xeeb tub. Hauv chav kawm ntawm kev tshawb fawb ntawm Levemir Penfill kev daws teeb meem hauv cov tsiaj, tsis muaj embryotoxic thiab teratogenic effect tau tshwm sim.
Thaum cev xeeb tub, yuav tsum tau saib xyuas cov ntshav qabzib ntau dua, uas cuam tshuam nrog kev hloov pauv hauv cov tshuaj insulin thoob plaws lub sijhawm cev xeeb tub. Cov poj niam hauv thawj peb ntawm cev xeeb tub yuav xav tau cov tshuaj insulin tsawg dua, thaum lub hlis thib ob thiab zaum peb, xav tau cov tshuaj insulin tuaj yeem nce ntau. Tom qab yug menyuam, hauv feem ntau cov neeg mob, xav tau cov tshuaj insulin rov mus rau qhov qub (ib qho uas tau sau tseg ua ntej cev xeeb tub).
Thaum lub sijhawm lactation, cov poj niam yuav xav tau kev hloov kho koob tshuaj thiab cov tshuaj tiv thaiv kab mob siab, nrog rau kev hloov pauv zaub mov.
Yeeb tshuaj sib cuam tshuam
Levemir Penfill yog siv tsis tau nrog lwm cov tshuaj ntxiv. Levemir Penfill tsis sib xyaw nrog txoj kev lis ntshav thiab kev txhaj tshuaj hauv tib lub syringe lossis kab ke.
Dosages ntawm cov tshuaj insulin yuav tsum tau hloov kho thaum ua ke nrog cov tshuaj uas hloov kev ua yeeb yam los ntawm insulin lossis kev xav tau insulin. Thaum sau ntawv noj tshuaj ib qho twg, kev saib xyuas yuav tsum tau noj thiab thawj zaug, soj ntsuam cov ntshav qabzib ntau npaum li cas.
Muaj ib qho kev poob qis hauv kev xav tau hauv insulin nyob rau hauv kev sib txuas nrog kev kho mob nrog cov tsis raug xaiv beta-adrenoreceptor blockers, monoamine oxidase inhibitors, cov tshuaj tiv thaiv kab mob hypoglycemic hauv qhov ncauj, salicylates, angiotensin-hloov mus rau enzyme inhibitors thiab tshuaj uas muaj ethanol.
Muaj kev nce ntxiv ntawm kev xav insulin hauv kev kho ua ke nrog kev loj hlob hormone, beta-adrenergic agonists, glucocorticosteroids, thyroid hormones, thiazide diuretics thiab danazole.
Nws yuav tsum tau yug los rau hauv lub siab tias thaum kho nrog beta-blockers npog cov tsos mob ntawm kev mob ntshav qab zib thiab nce lub sijhawm rov qab los ntawm cov theem ib txwm muaj ntshav qabzib.
Ethanol nrog kev sib xyaw ua ke tuaj yeem txhim kho qhov ntev thiab qhov hnyav ntawm qhov cuam tshuam ntawm insulin.
Ua ke ntawm kev siv octreotide / lanreotide tuaj yeem hloov qhov xav tau ntawm insulin (nyob ntawm qee tus neeg txawv, tus neeg mob yuav tsum tau nce lossis txo qis dua cov tshuaj insulin).
Noj ntau dhau
Lub tswv yim tshwj xeeb ntawm kev qaug cawv rau cov tshuaj insulin tsis yog tsim. Nrog kev qhia txog cov koob tshuaj insulin tseem ceeb tshaj li qhov xav tau ntawm tus neeg mob, qhov pom ntawm hypoglycemia tau sau tseg. Qhov mob hnyav ntawm cov ntshav qog ntshav nce siab yuav nyob ntawm koob tshuaj insulin:
- Nrog cov ntshav qog ntshav qab zib tsawg, cov neeg mob tau qhia kom noj cov khoom qab zib (piv txwv li, ob peb daim qab zib).
- Hauv kev mob ntshav qis, yog tias tus neeg mob tsis nco qab lawm, glucagon yuav tsum tau txhaj tshuaj subcutaneously thiab mus rau hauv cov leeg nqaij ntawm qhov koob ntawm 0.5-1.0 mg (kev tswj hwm yuav tsum tau nqa los ntawm cov neeg uas tau qhia raws li). Yog tias tsim nyog, kev qhia txog kev daws teeb meem niam txiv cov kua nplaum. Qhov qhia txog cov piam thaj yog qhov tsim nyog yog tias tom qab 10-15 feeb los ntawm kev qhia ntawm glucagon tsis muaj kev txhim kho ntawm tus neeg mob tus neeg mob.
Txhawm rau kom tsis txhob rov mob ntxiv tom qab ua kom lub cev ntawm tus neeg mob lub neej, kev noj zaub mov hauv qhov ncauj ntawm carbohydrates yog pom zoo.
Cia rau cov neeg mob
Levemir Penfill hauv qhov lim dej airtight (ua ntej siv) yog khaws cia ntawm qhov kub ntawm 2 txog 8 degrees Celsius.
Nws yog txwv tsis pub khov rau cov tshuaj Levemir Penfill.
Txee lub neej yog 24 lub hlis.
Tom qab koj pib siv lub Levemir Penfill cartridge, koj yuav tsum khaws nws ntawm chav kub (cov tshuaj siv nrog Novo Nordisk saib xyuas thiab nqa nrog nws).
Txee lub neej tom qab pib siv daim cartridge yog 6 lub lis piam.
Levemir Penfill yuav tsum cia nyob deb ntawm cov menyuam yaus.
Cov chaw muag tshuaj
Levemir ® FlexPen ® yog soluble analogue ntawm basal insulin nrog qhov ua ntev ntev, uas siv los ua cov insulin basal.
Qhov twv ua ntej ntawm cov tshuaj muaj tseeb dua li cov tshuaj insulin tsis haum tshuaj Hagedorn (NPH-insulin) thiab insulin glargine. Lub sijhawm ua haujlwm ntev ntawm cov tshuaj yog vim muaj kev sib raug zoo ntawm qhov ua kom insulin cov kua dej ntawm cov chaw txhaj tshuaj thiab qhov sib ntxiv ntawm cov albumin rau lawv los ntawm cov kab npauj ntsaws ntawm cov kua roj. Piv nrog insulin NPH, detemir insulin yog qeeb dua hauv peripheral phiaj cov ntaub so ntswg. Qhov kev sib koom ua ke ntawm lub sijhawm ntev ntawm kev ua haujlwm ua rau kom paub tseeb txog kev nqus thiab kev ua haujlwm ntawm cov tshuaj Levemir ® FlexPen ® tshaj li cov tshuaj insulin NPH.
Cov suab thaj txo qis ntawm cov tshuaj yog txhawb kev noj ntawm cov piam thaj los ntawm cov ntaub so ntswg tom qab khi ntawm cov insulin rau cov txais ntawm cov leeg thiab cov rog, nrog rau kev cuam tshuam ntawm kev tso tawm cov piam thaj hauv lub siab.
Cov nyhuv ntawm cov tshuaj yuav kav ntev txog 24 teev, nyob ntawm seb lub koob tshuaj, uas tso cai rau koj yuav tsum tau txwv nrog ib lossis ob koob txhaj ib hnub. Nrog kev nthuav qhia ntawm ob zaug ib hnub ib zaug muaj zog ntawm glycemia tuaj yeem ua tiav tom qab 2-3 hno. Nrog rau kev qhia ntawm cov tshuaj Levemir ® FlexPen ® ntawm tus nqi ntawm 0.2-0.4 U / kg lub cev qhov hnyav ntau dua 50% ntawm cov nyhuv siab tshaj plaws tau tiav tom qab 3-4 teev thiab kav ntev txog 14 teev tom qab txhaj tshuaj.
Tom qab kev coj ua ntawm cov tshuaj, cov tshuaj pharmacological (qhov siab tshaj plaws, lub sijhawm ntawm kev txiav txim, tag nrho cov nyhuv) yog qhov sib npaug rau cov tshuaj ntawm cov tshuaj.
Thaum lub sijhawm kuaj mob mus ntev, kev siv cov tshuaj Levemir ® FlexPen ® muab tsawg dua txhua hnub ua rau cov kua nplaum yoo piv rau insulin NPH.
Raws li kev tshawb nrhiav nrog cov neeg mob ntshav qab zib hom II uas siv insulin basal insulin ua ke nrog cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, qhov ua tau zoo ntawm glycemic tswj (HbA 1C) nrog Levemir ® FlexPen ® piv rau cov hauj lwm zoo ntawm insulin NPH thiab insulin glargine, thaum lub sijhawm lub cev hnyav dua me me (cov lus. 1).
Hloov hauv lub cev qhov hnyav tom qab kho cov tshuaj insulin
| kawm ntev | Pom tawm cov tshuaj insulin ib hnub ib zaug | Muab tshuaj ntsuab insulin ob zaug txhua hnub | NPH-insulin | insulin glargine |
| 20 lub lis piam | 0.7 kg | +1.6 kg | ||
| 26 lub lis piam | +1.2 kg | + 2.8 kg | ||
| 52 lub lim tiam | + 2.3 kg | +3.7 kg | + 4.0 kg |
Hauv cov pab pawg ntawm cov neeg mob uas tau txais kev kho mob ua ke nrog cov tshuaj tiv thaiv hypoglycemic thiab Levemir ® FlexPen cases, cov neeg mob ntshav qab zib tsawg hmo tau pom ntawm 61-65% tsawg dua nrog insulin NPH.
Qhib kev soj ntsuam kev sib tham nrog kev sim ntshav qab zib hom II cov neeg mob siv tshuaj tiv thaiv kab mob hauv lub qhov ncauj tsis ncav cuag lub hom phiaj glycemic tswj theem, thiab pib nrog 12-lub lim tiam npaj rau lub sijhawm uas cov neeg mob tau txais liraglutide + metformin. Thaum kawg ntawm lub sijhawm no, hauv 61% ntawm cov neeg mob, theem ntawm HbA 1C poob qis
Kev kho mob ntshav qab zib rau cov neeg laus thiab cov menyuam laus dua 2 xyoos.
Kev sib cuam tshuam nrog lwm yam tshuaj thiab lwm yam kev sib cuam tshuam
Raws li koj paub, ntau ntawm cov tshuaj cuam tshuam rau cov metabolism hauv cov piam thaj, uas yuav tsum tau txiav txim siab thaum txiav txim qhov koob tshuaj insulin.
Cov tshuaj uas yuav txo qhov xav tau insulin
Cov tshuaj tiv thaiv kab mob rau lub cev (PSS), monoamine oxidase inhibitors (MAOs), tsis muaj kev xaiv b-blockers, ACE inhibitors (ACE), salicylates, anabolic steroids thiab sulfonamides.
Cov tshuaj uas tuaj yeem xav tau cov insulin ntau ntxiv
Cov tshuaj tiv thaiv hauv qhov ncauj, thiazides, glucocorticoids, cov thyroid hormones, sympathomimetics, kev loj hlob hormone thiab danazole.
- Cov blockers tuaj yeem npog cov tsos mob ntawm kev mob hypoglycemia.
Octreotide / lanreotide tuaj yeem ob leeg nce thiab txo qis qhov kev xav tau rau insulin.
Cov cawv yuav pab txhim kho thiab ua kom ntev li ntawm cov nyhuv hypoglycemic ntawm insulin.
Daim ntawv thov nta
Ua ntej taug kev hauv thaj chaw sib txawv, cov neeg mob yuav tsum sab laj nrog tus kws kho mob, vim tias qhov kev hloov no tau teem sij hawm ntawm cov tshuaj insulin thiab kev noj zaub mov.
Kev noj tshuaj kom tsis txaus lossis tsis ua haujlwm ntawm kev kho mob (tshwj xeeb tshaj yog muaj ntshav qab zib hom I) tuaj yeem ua rau hyperetcemia thiab ntshav qab zib ketoacidosis. Feem ntau, thawj cov tsos mob ntawm hyperglycemia pib maj mam dhau ob peb teev lossis hnub. Lawv suav nrog nqhis dej, tso zis tsis tu ncua, xeev ntuav, ntuav, nkees, liab thiab daj ntawm daim tawv nqaij, qhov ncauj qhuav, tsis qab los noj mov, thiab tsis hnov ntxhiab ntawm cov acetone hauv cov pa tawm.
Hauv cov ntshav qab zib hom I, hyperglycemia, uas tsis kho, ua rau ketoacidosis uas mob ntshav qab zib, uas ua rau muaj kev tuag taus.
Noj zaub mov los yog ua tej yam tsis zoo rau lub cev ua rau lub cev tsis muaj ntshav qab zib.
Kev mob hypoglycemia tuaj yeem tshwm sim thaum cov koob tshuaj insulin ntau dua li tus neeg mob xav tau.
Levemir ® FlexPen ® yuav tsum tsis txhob siv nrog lub qog ntshav qab zib lossis yog tias muaj lub siab xav tias tus neeg mob ua rau lub qog ntshav qab zib.
Cov neeg mob uas tau txais kev tswjhwm zoo tshaj plaws ntawm cov ntshav qabzib ntau vim kev siv tshuaj insulin ntau ntxiv tuaj yeem pom qhov txawv txav hauv lawv cov tsos mob ib txwm muaj, kev tawm tsam sai ntawm hypoglycemia, uas yuav tsum ceeb toom ua ntej. Cov tsos mob tshwm sim ua ntej yuav ploj mus nyob hauv cov neeg mob ntshav qab zib ntev.
Cov kab mob tsis haum, tshwj xeeb tshaj yog kis mob thiab kub ib ce, feem ntau ua rau tus neeg mob xav tau cov tshuaj insulin. Qhov yuav tsum tau hloov cov koob tshuaj insulin tuaj yeem tshwm sim nrog cov kab mob concomitant uas cuam tshuam rau lub raum, mob siab, cov qog, cov qog pituitary lossis cov thyroid caj pas.
Thaum hloov mus rau cov neeg mob mus rau lwm hom insulin, thaum ntxov ntawm cov mob ntshav qab zib ua ntej yuav hloov lossis ua cov lus tsawg dua piv rau kev npaj insulin yav dhau los.
Hloov tsheb los ntawm lwm yam tshuaj insulin
Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis hom insulin tshwm sim nyob rau hauv kev saib xyuas mob nkeeg nruj. Kev hloov pauv ntawm cov kev xav, hom (chaw tsim khoom), hom, keeb kwm ntawm insulin (tib neeg lossis kev sib piv ntawm tib neeg cov insulin) thiab / lossis cov txheej txheem ntau lawm yuav tsum tau tsim kho cov tshuaj insulin. Thaum hloov chaw rau tus neeg mob mus rau kev txhaj tshuaj ntawm Levemir ® FlexPen ®, nws yuav tsim nyog hloov pauv ntawm kev txhaj tshuaj li qub. Qhov kev xav tau ntawm kev xaiv koob tshuaj yuav tshwm sim ob qho tib si hauv thawj zaug kev siv tshuaj tshiab, thiab nyob rau thawj ob peb lub lis piam lossis lub hlis ntawm kev siv.
Kev txhaj tshuaj ntawm qhov chaw
Thaum siv cov tshuaj insulin, cov tshuaj tiv thaiv nyob rau ntawm qhov chaw txhaj tshuaj yuav tshwm sim hauv daim ntawv ntawm qhov mob, liab, khaus, urticaria, doog, o, thiab o. Hloov pauv ntawm qhov chaw txhaj tshuaj tuaj yeem txo qhov zaus lossis tiv thaiv kev txhim kho ntawm cov kev cuam tshuam no. Cov kev tawm tsam feem ntau yuav ploj mus tom qab ob peb hnub lossis vas thiv. Tsis tshua muaj, kev hloov pauv ntawm thaj chaw txhaj tshuaj yuav xav kom tsis txhob siv cov tshuaj Levemir ® FlexPen ®.
Cov ntaub ntawv hais txog kev siv cov tshuaj nyob rau hauv cov neeg mob uas mob ntshav qab zib hypoalbuminemia tsawg. Pom zoo saib xyuas tus mob ntawm cov neeg mob no raug pom zoo.
Kev sib xyaw ntawm thiazolidinediones (pioglitazone, rosiglitazone) kev npaj tshuaj insulin
Thaum thiazolidinediones siv nrog kev siv tshuaj insulin, cov mob ntawm lub plawv tsis ua haujlwm tau tshaj tawm, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kev pheej hmoo rau txoj kev tsis ua haujlwm txhawm rau lub siab. Qhov no yuav tsum tau txiav txim siab thaum sau ntawv kho mob nrog kev sib xyaw ntawm thiazolidinediones nrog insulin. Nrog kev siv cov tshuaj no ua ke, cov neeg mob yuav tsum tau saib xyuas los ntawm kws kho mob rau kev txhim kho cov cim thiab cov tsos mob ntawm lub plawv tsis ua hauj lwm hnyav, hnyav ntxiv thiab tshwm sim ntawm edema. Yog tias lub cev tsis ua hauj lwm hauv lub plawv, kho nrog thiazolidinediones yuav tsum tsis ua mus ntxiv.
Siv thaum cev xeeb tub lossis lactation.
Levemir ® FlexPen ® tuaj yeem siv thaum cev xeeb tub, tab sis tib lub sijhawm, cov txiaj ntsig zoo yuav tsum piv nrog kev pheej hmoo ntawm kev pheej hmoo tsis zoo nyob rau hauv chav xeeb menyuam.
Nws raug nquahu kom tswj nruj rau kev kho mob rau cov poj niam cev xeeb tub uas muaj ntshav qab zib thoob plaws lub sijhawm sijhawm cev xeeb tub, nrog rau cov neeg xav tias cev xeeb tub. Qhov kev xav tau rau cov tshuaj insulin feem ntau poob qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce ntau hauv cov qib thib ob thiab thib peb. Tom qab yug los, xav tau cov tshuaj insulin sai sai rov qab rau hauv paus.
Hauv kev qhib, kev tswj xyuas qhov chaw kho mob tau sim nrog poj niam cev xeeb tub (n = 310) nrog ntshav qab zib hom 1, ib pawg (n = 152) tau txais Levemir ® FlexPen ® nyob rau hauv kev noj qab haus huv, thiab ob (n = 158) raws li insulin basal - cov tshuaj tiv thaiv nruab nrab ntawm Hagedorn (NPH-insulin). Ob pawg tau txais Novorapid-bolus.
Lub hom phiaj tseem ceeb ntawm txoj kev tshawb fawb no yog soj ntsuam qhov ua tau zoo ntawm Levemir ® FlexPen ® txhawm rau ua kom txoj cai ntawm cov ntshav qab zib nyob rau hauv cov poj niam cev xeeb tub muaj ntshav qab zib. Cov txiaj ntsig tau qhia txog tib yam kev ua tau zoo ntawm insulin detemir thiab NPH-insulin thaum cev xeeb tub, nrog rau kev nyab xeeb ntawm lawv siv rau kev xeeb tub, kev loj hlob ntawm tus me nyuam hauv plab thiab cov menyuam yug tshiab.
Cov ntaub ntawv ntxiv ntawm cov txiaj ntsig kev xeeb tub tau txais tom qab cov tshuaj tau tsim tawm mus rau tom khw rau 300 tus poj niam uas tau kho nrog Levemir P FlexPen that qhia tias nws tsis cuam tshuam rau kev xeeb tub, nws tsis ua rau muaj kev pheej hmoo ntawm cov me nyuam hauv plab tsis zoo thiab tsis muaj kev phom sij rau menyuam hauv plab thiab cov menyuam tshiab.
Cov kev sim tsiaj txhu tsis tau qhia txog qhov tshwm sim ntawm Levemir ® FlexPen ® ntawm kev muaj peev xwm ntawm kev ua me nyuam.
Tsis paub txog, insemir insulin ua rau sab hauv niam mis. Koj yuav tsum tsis txhob xav tias yuav muaj txiaj ntsig dab tsi rau cov menyuam mos, txij li nyob hauv tus me nyuam cov zom zaub mov, insulin detemir li peptide yog zom rau cov amino acids.
Thaum lub sijhawm pub niam mis, nws yuav tsim nyog kho lub koob tshuaj insulin thiab kev noj haus.
Cov kev tshawb fawb tsiaj tseem tsis tau qhia txog qhov ua rau lub cev tsis zoo.
Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem.
Tus neeg mob cov lus teb thiab nws lub peev xwm los mloog zoo yuav ua rau lub plawv tsis muaj ntshav qab zib. Qhov no tuaj yeem ua rau muaj kev pheej hmoo hauv cov xwm txheej uas cov peev xwm no muaj qhov tshwj xeeb tseem ceeb (piv txwv li, thaum tsav tsheb lossis ua haujlwm nrog tshuab).
Cov neeg mob yuav tsum qhia rau lawv kom ntsuas los tiv thaiv kom tsis txhob muaj ntshav qab zib ua ntej tsav tsheb. Qhov no yog qhov tshwj xeeb tshaj yog rau cov neeg mob uas tsis muaj zog lossis tsis muaj cov tsos mob tshwm sim ua ntej ntawm lub qog ntshav ntshav lossis lub sijhawm ntog ntshav siab tsis tshua tshwm sim ntau zaus. Thaum muaj teeb meem li no, qhov tsim nyog ntawm kev tsav tsheb yuav tsum ntsuas.
Kev phiv tshuaj
Cov kev phiv tsis zoo pom nyob rau hauv cov neeg mob uas tau txais Levemir ® FlexPen ® yog qhov kev tshwm sim ntawm qhov kev ua tshuaj ntawm insulin. Tag nrho cov kev cia siab tias yuav muaj qhov tshwm sim tsis zoo hauv cov neeg mob noj cov tshuaj no yog 12%.
Cov kev phiv los cuam tshuam ntawm kev kho mob insulin yog hypoglycemia. Cov kev tshawb fawb soj ntsuam tau pom tias cov neeg mob ntshav nce siab ntau, uas qhov xav tau kev kho mob los ntawm lwm tus, tshwm sim hauv kwv yees li 6% ntawm cov neeg mob tau txais Levemir ir FlexPen ®.
Cov tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj ntawm Levemir ® FlexPen somewhat muaj qee yam tshwm sim ntau dua li thaum siv tib neeg cov tshuaj insulin. Cov kev tshwm sim no suav nrog kev mob, liab liab, khaus, mob, doog, o, thiab khaus ntawm qhov chaw txhaj tshuaj. Feem ntau lawv kis tau sai heev nyob rau ntau hnub lossis ntau lub lim tiam nrog kev kho mob txuas mus ntxiv.
Thaum pib ntawm kev siv tshuaj insulin, qhov rov ua yuam kev yuav tshwm sim thiab edema feem ntau yog ib ntus. Kev txhim kho sai ntawm cov ntshav qabzib tuaj yeem cuam tshuam rau lub xeev ntawm "mob mob neuropathy," uas feem ntau thim rov qab. Kev txhim kho ntse hauv glycemic tswj vim tias kev siv tshuaj insulin ntau ntxiv tuaj yeem nrog lub sij hawm exacerbation ntawm cov ntshav qab zib retinopathy, thaum lub sijhawm ntev tsim tau glycemic tswj txo qhov kev pheej hmoo ntawm kev mob ntshav qab zib retinopathy.
Cov kev tshwm sim tsis zoo hauv qab no tau pom thaum kuaj sim, cov xwm txheej tau faib raws li chav kawm ntawm nruab nrog cev nruab nrog cev MedDRA. Los ntawm cov tshuaj tiv thaiv ntau zaus, lawv muab faib rau cov uas muaj tshwm sim ntau (≥ 1/10), feem ntau (≥ 1/100, 1/1000,
Incompatibility
Cov tshuaj uas ntxiv rau detemir insulin tuaj yeem ua rau nws rhuav tshem, piv txwv li, kev npaj muaj thiols lossis sulfites. Levemir ® FlexPen ® tsis tuaj yeem muab ntxiv rau qhov kev daws teeb meem.
Levemir ® FlexPen ® yuav tsum tsis txhob muab sib xyaw nrog lwm cov tshuaj.
Ib qho ua ntej ntim ntau qhov kev txhaj tshuaj uas siv tus cwj mem muaj 3 ml cartridge ua los ntawm iav (hom 1) thiab tau muab ntim rau ntawm ib sab nrog lub piston nrog bromobutyl roj hmab thiab ntawm lwm qhov nrog tus nres txhaws nrog bromobutyl / polyisoprene roj hmab. Lub hau fais fab yog ua los ntawm cov yas. 5 los yog 1 xaum xaum hauv lub thawv ntawv.
Cov lus qhia rau kev siv
| Pharmacological kev txiav txim | Zoo li lwm hom insulin, Levemir txo qis cov ntshav qab zib, ua rau lub siab thiab cov leeg nqaij kom nqus tau cov piam thaj. Cov tshuaj no tseem ua rau kev hloov ua ke ntawm cov protein thiab ua kom cov piam thaj hloov mus rau rog. Nws yog tsim los txhawb kev tiv thaiv kev mob ntshav qab zib ceev, tab sis tsis pab nce qab zib tom qab noj mov. Yog tias tsim nyog, siv cov kev qhia luv luv lossis chaw tso ntshav ntxiv ntxiv rau cov tshuaj tua kab mob ntev ntev. |
| Cov Tshuaj Pharmacokinetics | Txhua qhov kev txhaj tshuaj ntawm cov tshuaj no kav ntev dua li kev txhaj tshuaj ntawm cov tshuaj nruab nrab los tiv thaiv Protafan. Cov cuab yeej no tsis muaj qhov xaus ntawm qhov kev txiav txim siab. Cov lus qhia raug raws cai tau hais tias Levemir ua haujlwm txawm tias yuav ncaj ncees dua Lantus, uas yog nws cov neeg sib tw tseem ceeb. Txawm li cas los xij, cov tsim tawm cov roj ntsha tsis txaus yuav tsis pom zoo nrog qhov no :). Nyob rau hauv txhua rooj plaub, cov tshuaj tshiab Tresiba qis qis dua cov piam thaj hauv cov ntshav qab zib ntev dua (txog li 42 teev) thiab ntseeg nkaws dua li Levemir thiab Lantus. |
| Kev ntsuas rau siv | Hom 1 thiab hom 2 mob ntshav qab zib mellitus, uas yuav tsum txhaj tshuaj insulin kom ua tiav cov nyiaj them zoo rau cov piam thaj hauv cov ntshav. Nws tuaj yeem raug kho rau cov menyuam yaus txij thaum muaj 2 xyoos, thiab tseem ntau dua rau cov laus thiab cov neeg laus. Nyeem kab lus "Kev Kho Mob Ntshav Qab Zib Hom 1 ntawm Cov Neeg Mob thiab Cov Menyuam" lossis "Insulin rau Ntshav Qab Zib Hom 2". Levemir yog cov tshuaj ntawm kev xaiv rau cov menyuam muaj ntshav qab zib uas yuav tsum tau txhaj tshuaj tsawg dua li 1-2 units. Vim tias nws tuaj yeem raug diluted, tsis zoo li insulin Lantus, Tujeo thiab Tresiba. |
Thaum txhaj cov tshuaj Levemir, zoo li lwm hom insulin, koj yuav tsum ua raws li kev noj zaub mov noj.
| Cov Yuav Tsum Muaj | Ua xua rau cov insulin detemir lossis ntu sib xyaw hauv qhov sib xyaw ntawm kev txhaj tshuaj. Tsis muaj cov ntaub ntawv los ntawm kev tshawb fawb soj ntsuam ntawm cov tshuaj no muaj feem cuam tshuam rau cov menyuam yaus uas muaj hnub nyoog qis dua 2 xyoos. Txawm li cas los xij, tsis muaj cov ntaub ntawv zoo li no rau cov sib tw ntawm hom tshuaj insulin kuj. Yog li Levemir siv tsis raug cai siv los them nyiaj mob ntshav qab zib txawm nyob hauv cov menyuam yaus me tshaj plaws. Ntxiv mus, nws tuaj yeem hloov mus. |
| Cov lus qhia tshwj xeeb | Tshawb xyuas ib tsab xov xwm hais txog yuav ua li cas kis cov kab mob kis, kev nyuaj siab thiab ntev, thiab huab cua cuam tshuam rau cov insulin xav tau ntawm cov ntshav qab zib. Nyeem yuav ua li cas muab cov ntshav qab zib sib xyaw nrog cov tshuaj insulin thiab cawv. Tsis txhob ua tub nkeeg kom txhaj tshuaj Levemir 2 zaug hauv ib hnub, tsis txhob txwv koj tus kheej rau kev txhaj ib hnub. Cov kua dej no tuaj yeem tsim tau yog tias tsim nyog, tsis zoo li npaj ntawm Lantus, Tujeo thiab Tresiba. |
| Tsuas tshuaj | Kawm cov lus "Kev xam cov koob tshuaj Insulin ntev rau kev txhaj tshuaj thaum tsaus ntuj thiab thaum sawv ntxov". Xaiv qhov zoo tshaj plaws ntawm lub cev, nrog rau cov caij nyoog ntawm kev txhaj tshuaj ib tus zuj zus, raws li cov txiaj ntsig ntawm kev soj ntsuam cov ntshav qab zib rau ob peb hnub. Tsis txhob siv cov qauv pom zoo kom pib nrog 10 PIECES lossis 0.1-0.2 PIECES / kg. Rau cov neeg mob ntshav qab zib uas ua raws li cov zaub mov noj qab zib qis, qhov no ntau dhau lawm. Thiab tseem muaj ntau dua li ntawd rau menyuam yaus. Nyeem cov ntawv “Insulin administration: qhov twg thiab yuav ua li cas laum”. |
| Sab sij huam | Kev phiv tshuaj txaus ntshai yog cov piam thaj hauv ntshav tsawg (muaj ntshav qab zib tsawg). Nkag siab tias cov tsos mob ntawm tus mob no yog li cas, yuav ua li cas pab tus neeg mob. Hauv qhov chaw ntawm kev txhaj tshuaj muaj cov tawv nqaij liab thiab khaus. Cov kev txhaum fab hnyav muaj tsawg dua. Yog tias qhov kev pom zoo raug ua txhaum, lwm qhov chaw txhaj tshuaj tuaj yeem tsim kho lipohypertrophy. |
Ntau tus neeg mob ntshav qab zib uas kho tau cov tshuaj insulin pom tias nws tsis tuaj yeem ua kom tsis txhob muaj mob ntshav qab zib. Qhov tseeb, qhov no tsis yog li ntawd. Koj tuaj yeem khaws cov suab thaj kom ruaj Txawm hais tias muaj mob hnyav autoimmune. Thiab ntau heev tshaj dua yog li, nrog cov mob hnyav hom 2 mob ntshav qab zib. Tsis tas yuav ua los ntxiv cov ntshav qabzib hauv koj lub cev txhawm rau kom raug tus kheej tiv thaiv ntshav qabzib ntshav qab zib. Saib cov vis dis aus uas Dr. Bernstein tham txog qhov teebmeem no.
| Kev cuam tshuam nrog lwm yam tshuaj | Cov tshuaj uas tuaj yeem txhim kho cov tshuaj insulin muaj xws li txo cov tshuaj qab zib, nrog rau ACE inhibitors, disopyramides, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates thiab sulfonamides. Lawv tuaj yeem ua kom tsis muaj zog ntawm kev txhaj tshuaj: danazol, diazoxide, diuretics, glucagon, isoniazid, estrogens, gestagens, phenothiazine derivatives, somatotropin, epinephrine (adrenaline), salbutamol, terbutaline thiab cov thyroid hormones, protease inhibitors, olanzapine, Tham nrog koj tus kws kho mob txog txhua yam tshuaj koj noj! |
| Noj ntau dhau | Yog tias cov tshuaj tau muab ntau dua rau tus neeg mob, mob ntshav qab zib siab heev tuaj yeem tshwm sim, nrog kev tsis nco qab thiab tsis nco qab lawm. Nws cov txiaj ntsig yog tsis tuaj yeem ua kom lub hlwb puas, thiab ua kom tuag. Lawv yog cov uas tsis tshua muaj, tshwj tsis yog muaj xwm txheej ntawm txhob txwm tshaj tawm. Rau Levemir thiab lwm hom insulin ntev ntev, qhov kev pheej hmoo yog qhov tsawg tshaj plaws, tab sis tsis xoom. Nyeem ntawm no yuav ua li cas muab kev pabcuam kub ntxhov rau tus neeg mob. |
| Daim ntawv tso tawm | Levemir zoo li meej meej thiab tsis muaj kev daws teeb meem. Nws raug muag hauv 3 ml cartridges. Cov cartridges no muaj peev xwm yuav tsum tau mounted nyob rau hauv FlexPen disposable syringe cwjmem nrog qhov muab tshuaj ntawm 1 ntsuas. Ib cov tshuaj uas tsis muaj phwj nrog tshuaj yog hu ua Penfill. |
| Cov lus thiab cov xwm txheej ntawm kev cia | Zoo li lwm hom tshuaj insulin, cov tshuaj Levemir yog qhov tsis yooj yim heev, nws tuaj yeem cuam tshuam yooj yim. Txhawm rau zam qhov no, kawm txog txoj cai khaws cia thiab ua tib zoo ua raws li lawv. Lub txee lub neej ntawm daim cartridge tom qab qhib yog 6 lub lis piam. Cov tshuaj, uas tseem tsis tau pib siv, tuaj yeem khaws cia rau hauv tub yees rau 2.5 xyoo. Tsis khov! Khaws tsis ncav cuag ntawm cov menyuam yaus. |
| Muaj pes tsawg leeg | Cov tshuaj nquag yog insulin detemir. Cov kev zam - glycerol, phenol, metacresol, zinc acetate, sodium hydrogen phosphate dihydrate, sodium chloride, hydrochloric acid los yog sodium hydroxide, dej rau kev txhaj tshuaj. |
Saib hauv qab no rau cov lus qhia ntxiv.
Puas yog levemir insulin ntawm qhov kev txiav txim twg? Yog ntev lossis luv?
Levemir yog cov tshuaj insulin ntev ntev. Txhua koob tshuaj tau txo qis cov ntshav qab zib hauv 18-24 teev. Txawm li cas los xij, cov neeg mob ntshav qab zib uas ua raws li cov zaub mov noj muaj carb qis yuav tsum tau noj tsawg kawg, 2-8 zaug qis dua li cov qauv. Thaum siv cov tshuaj zoo li no, cov nyhuv ntawm cov tshuaj xaus sai dua, hauv 10-16 teev. Tsis zoo li cov tshuaj insulin nruab nrab, Levemir tsis muaj lub suab nrov tshaj plaws. Ua tib zoo saib xyuas cov tshuaj tshiab Tresib, uas kav ntev dua, ntev txog li 42 teev, thiab zoo nkauj dua.
Levemir tsis yog cov tshuaj insulin luv luv. Nws tsis haum rau tej qhov xwm txheej uas koj xav tau kom sai qab zib qab zib. Thiab, nws yuav tsum tsis txhob ua ntej ua ntej noj mov kom paub txog cov khoom noj uas muaj ntshav qab zib kom noj. Rau cov laj thawj no, kev npaj kom luv lossis ultrashort tau siv. Nyeem kab lus "Cov hom insulin thiab lawv cov kev coj ua" hauv cov ntsiab lus ntau ntxiv.
Saib cov video ntawm Dr. Bernstein. Tshawb nrhiav yog vim li cas Levemir zoo dua li Lantus. Nkag siab pes tsawg zaus ib hnub koj xav tau prick nws thiab lub sijhawm. Kuaj xyuas tias koj khaws koj cov tshuaj insulin kom raug nws thiaj tsis puas.
Yuav xaiv cov koob li cas?
Cov koob tshuaj ntawm Levemir thiab txhua lwm hom insulin yuav tsum tau xaiv ib tus zuj zus. Rau cov laus ntshav qab zib, muaj cov qauv kev pom zoo pib nrog 10 PIECES lossis 0.1-0.2 PIECES / kg. Txawm li cas los xij, rau cov neeg mob uas ua raws li cov zaub mov noj muaj carb qis, qhov tshuaj no yuav siab dhau. Saib xyuas koj cov piam thaj hauv ntshav tau ob peb hnub. Xaiv qhov zoo tshaj plaws hauv cov tshuaj insulin uas siv cov ntaub ntawv tau txais. Nyeem ntxiv hauv kab lus "Kev xam ntawm cov koob tshuaj ntev ntawm cov insulin rau kev txhaj tshuaj thaum hmo ntuj thiab yav sawv ntxov."
Ntau npaum li cas cov tshuaj no yuav tsum raug txhaj tshuaj rau hauv menyuam yaus hnub nyoog 3 xyoos?
Nws nyob ntawm seb hom khoom noj dab tsi uas cov menyuam muaj ntshav qab zib ua raws. Yog tias nws tau pauv mus rau cov khoom noj uas tsis muaj cov kab mob hauv lub cev, tom qab ntawd cov koob tshuaj qis heev, txhais tau hais tias homeopathic, yuav tsum muaj. Tej zaum, koj yuav tsum tau nkag rau Levemir thaum sawv ntxov thiab yav tsaus ntuj hauv cov koob tshuaj uas tsis pub ntau tshaj 1 chav nyob. Koj tuaj yeem pib nrog 0.25 units. Txhawm rau txhawm rau txhawm rau txhaj koob tshuaj tiv thaiv qis, nws yog qhov tsim nyog yuav tsum tov lub Hoobkas kev txhaj tshuaj. Nyeem ntxiv txog nws ntawm no.
Thaum mob khaub thuas, noj tshuaj lom thiab lwm yam kab mob kis, cov tshuaj insulin yuav tsum nce ntxiv li thaj tsam 1.5 zaug. Thov nco ntsoov tias kev npaj ua Lantus, Tujeo thiab Tresiba tsis tuaj yeem raug daws. Yog li no, rau cov menyuam yaus ntawm hom tshuaj insulin ntev ntev, tsuas yog Levemir thiab Protafan thiaj nyob ntev. Kawm cov lus "Ntshav Qab Zib Rau Cov Me Nyuam." Kawm yuav ua li cas txuas koj lub sijhawm honeymoon thiab tsim kom muaj cov ntshav qabzib tswj txhua hnub.
Yuav ua li cas nkaug Levemir? Pes tsawg zaus nyob rau ib hnub?
Levemir yuav tsis txaus prick ib hnub ib zaug. Nws yuav tsum raug tswj hwm ob zaug ib hnub - thaum sawv ntxov thiab tsaus ntuj. Ntxiv mus, kev ua ntawm qhov kev noj tshuaj yav tsaus ntuj feem ntau tsis txaus rau tag nrho hmo ntuj. Vim tias qhov no, tus neeg mob ntshav qab zib yuav muaj teeb meem qabzib thaum sawv ntxov nyob ntawm lub plab khoob. Nyeem kab lus “Qab zib rau ntawm ib plab khoob thaum sawv ntxov: yuav ua li cas coj nws rov mus nyob qhov qub”. Thiab kawm cov ntaub ntawv "Insulin tswj hwm: qhov twg thiab yuav ua li cas txhaj".
Cov tshuaj no puas sib piv nrog Protafan?
Levemir tau zoo dua li Protafan. Cov tshuaj Protafan insulin tsis dhau mus ntev, tshwj xeeb yog tias cov koob tshuaj no muaj tsawg. Cov tshuaj no muaj cov tsiaj protein protein, uas feem ntau ua rau ua xua. Nws yog qhov zoo dua kom tsis txhob siv cov tshuaj tiv thaiv protafan. Txawm hais tias cov tshuaj no tau muab pub dawb los, thiab lwm hom kev ncua sij hawm ntxiv yuav tsum tau yuav nyiaj. Mus rau Levemir, Lantus lossis Tresiba. Nyeem ntxiv hauv kab lus “Cov Hom Tshuaj insulin thiab Cov Cuam Tshuam”.
Qhov twg yog qhov zoo dua: Levemir lossis Humulin NPH?
Humulin NPH yog ib qho insulin ua haujlwm nruab nrab, zoo li Protafan. NPH yog cov tshuaj nruab nrab nruab nrab ntawm Hagedorn, tib cov protein uas feem ntau ua rau ua xua. kev tawm tsam. Humulin NPH yuav tsum tsis txhob siv cov laj thawj zoo ib yam li Protafan.
Levemir Penfill thiab Flekspen: Dab tsi yog qhov txawv?
Flekspen yog cov khoom lag luam uas tus cwjmem cwjmem hauv cov ntawv sau npe uas Levemir insulin daim cartridges. Penfill yog ib qho tshuaj Levemir uas tau muag uas tsis muaj cov xaum xaum es koj tuaj yeem siv cov tshuaj insulin tsis tu ncua. Flexspen cwjmem muaj ib daim ntawv qhia ntau npaum 1 daim. Qhov no tuaj yeem tsis yooj yim rau kev kho mob ntshav qab zib hauv cov menyuam yaus uas xav tau txhaj tshuaj qis. Hauv cov xwm txheej zoo li no, nws raug nquahu kom nrhiav thiab siv Penfill.
Levemir tsis muaj qhov pheej yig. Vim tias nws cov mis muaj kev tiv thaiv los ntawm daim ntawv sau txog patent uas nws qhov kev siv tau tseem tsis tau tas sij hawm. Muaj ntau ntau hom zoo xws li cov insulin ntev los ntawm lwm cov tuam ntxhab. Cov no yog cov tshuaj Lantus, Tujeo thiab Tresiba. Koj tuaj yeem kawm cov ncauj lus kom ntxaws txog lawv. Txawm li cas los xij, tag nrho cov tshuaj no tsis pheej yig. Cov tshuaj insulin rau nruab nrab, xws li Protafan, pheej yig dua. Txawm li cas los xij, nws muaj teeb meem tseem ceeb vim qhov uas Dr. Bernstein thiab endocrin-patient.com lub vev xaib tsis pom zoo siv nws.
Levemir lossis Lantus: uas cov insulin zoo dua?
Cov lus teb ntxaws ntxaws rau cov lus nug no tau muab nyob hauv tsab xov xwm ntawm insulin Lantus. Yog tias Levemir lossis Lantus haum rau koj, tom qab ntawd siv nws txuas ntxiv. Tsis txhob hloov ib qho tshuaj mus rau lwm qhov tshwj tsis yog qhov tsim nyog kiag li. Yog tias koj tab tom npaj yuav pib txhaj cov tshuaj insulin ntev, tom qab ntawd sim Levemir ua ntej. Treshiba's insulin tshiab zoo dua li Levemir thiab Lantus, vim tias nws siv sijhawm ntev thiab ntseeg nkaws. Txawm li cas los xij, nws tus nqi yuav luag 3 lub sijhawm kim dua.
Levemir thaum cev xeeb tub
Cov kev tshawb fawb loj hauv kev ntsuam xyuas tau ua uas tau pom tseeb qhov kev nyab xeeb thiab muaj txiaj ntsig ntawm kev tswj hwm ntawm Levemir thaum cev xeeb tub. Kev sib tw insulin hom Lantus, Tujeo thiab Tresiba tsis tuaj yeem khav tau cov pov thawj zoo li no ntawm lawv txoj kev nyab xeeb. Nws raug nquahu tias tus poj niam cev xeeb tub uas muaj ntshav qab zib kom nkag siab yuav ua li cas thiaj li suav cov koob tshuaj uas haum.
Cov tshuaj insulin tsis phom sij rau tus niam lossis tus menyuam hauv plab, qhia tias tsuas muab cov tshuaj ntau npaum li cas. Mob ntshav qab zib thaum cev xeeb tub, yog tias tsis kho, nws tuaj yeem ua teeb meem loj. Yog li no, txhaj tshuaj khov rau Levemir yog tias tus kws kho mob tau hais kom koj ua qhov no. Sim ua yam tsis muaj kev kho mob insulin, ua raws li kev noj haus zoo rau lub cev. Nyeem kab lus "Ntshav Qab Zib Cev Rau Mob Ntshav Qab Zib" thiab "Ntshav Qab Zib Zib Zes" rau cov lus qhia ntxiv.
Levemir tau siv los tswj hom 2 thiab ntshav qab zib hom 1 txij li ib nrab ntawm 2000s. Txawm hais tias cov tshuaj no muaj tus kiv cua tsawg dua li Lantus, kev tshuaj xyuas tau txaus tsim muaj ntau xyoo dhau los. Feem coob ntawm lawv yog cov zoo. Cov neeg mob nco ntsoov tias cov tshuaj insulin zoo txo cov ntshav qab zib. Nyob rau tib lub sijhawm, qhov kev pheej hmoo yuav mob ntshav qab zib siab tsawg heev.
Ib feem tseem ceeb ntawm kev tshuaj xyuas yog sau los ntawm cov poj niam uas tau siv Levemir thaum cev xeeb tub los tswj cov ntshav qab zib hauv poj niam. Yeej, cov neeg mob no tau txaus siab rau cov tshuaj. Nws tsis muaj yees, tom qab yug menyuam tas los tuaj yeem raug muab tso tseg yam tsis muaj teebmeem. Qhov tseeb yog qhov yuav tsum tau ua kom thiaj tsis ua yuam kev ntawm qhov tsuas tshuaj, tab sis nrog lwm cov tshuaj insulin los nws yog tib yam.
Raws li cov neeg mob, lub ntsiab tsis zoo yog tias lub laub pib yuav tsum siv hauv 30 hnub. Lub sijhawm no tsis ntev heev. Feem ntau koj yuav tsum pov tawm cov nqi tsis siv loj, thiab tom qab tag nrho, tau them nyiaj rau lawv. Tab sis txhua cov tshuaj sib tw muaj tib qho teeb meem. Kev kuaj xyuas ntshav qab zib paub meej tias Levemir yog zoo dua li ntawm qhov nruab nrab insulin Protafan hauv txhua qhov tseem ceeb.
14 lus hais txog "Levemire"
Kuv xav qhia kuv txoj kev ris txiaj rau qhov chaw tswj hwm rau cov ncauj lus kom ntxaws thiab muaj txiaj ntsig zoo. Vim tias cov zaub mov noj qis thiab noj cov tshuaj insulin tsawg dua Levemir, yoo mov qab zib thiab tom qab noj mov tau khaws cia rau hauv ib qho li ib txwm, qhov kev xav ntawm qhov tshwm sim tau tshwm sim. Yuav kom ua raws li kev noj haus zoo li no tsis yog ib qho nyuaj.
Vim tias cov zaub mov noj qis thiab qis kev txhaj tshuaj ntawm Levemir insulin, kev yoo mov thiab tom qab noj mov qab zib yog nyob rau hauv ib txwm muaj.
Zoo heev, cia li ua lawv txoj haujlwm.
Kuv qhia koj tias kuv tau faib Levemir ua 4 hno ib hnub nyob rau tib koob tshuaj, lawv txhua tus yog txhua tus 6 teev twg - thiab nws cov nyhuv tau zoo meej. Kuv nrhiav tau koj lub xaib, kawm nws ob hnub, tom qab ntawd hloov mus rau kev noj zaub mov kom tsawg thiab hloov kuv lub sijhawm kom txhaj tshuaj insulin. Hnub no yog ib lub lim tiam uas kuv nyob hauv lub tseem fwv tshiab - suab thaj tsis tau nce dua! Kuv tau muaj teeb meem qab zib rau ntawm ib qho khoob hauv plab vim thaum sawv ntxov kaj ntug - nws kuj tau txiav txim siab. Ua tsaug ntau rau lub xaib no! Cov neeg nyeem, cov khoom siv no yuav tsum ntseeg thiab kho, zoo li tau hais ntawm no!
qab zib yeej tsis sawv! Kuv tau muaj teeb meem qab zib rau ntawm ib qho khoob hauv plab vim thaum sawv ntxov kaj ntug - nws kuj tau txiav txim siab.
Zoo siab rau koj, khaws txoj haujlwm zoo.
Nyob zoo, nyob zoo! Kuv tus ntxhais yog 7 xyoo, nws tus mob ntshav qab zib muaj rau lub hlis. Tam sim no kuv tab tom kawm koj cov ntawv, Kuv yuav hloov pauv kuv kev noj zaub mov thiab txhua yam ntxiv, vim hais tias kev ua piam thaj thiab kev noj qab haus huv rau menyuam yaus yog qhov ua rau muaj kev ntxhov siab. Hauv ob lub lis piam dhau los, cov pob liab liab tau pib tshwm sim los ntawm Levemir kev txhaj tshuaj. Qhia rau kuv, puas yog nws fab tshuaj tsis haum lossis tsis yog?
cov pob liab tau pib tshwm sim los ntawm Levemir kev txhaj tshuaj. Qhia rau kuv, puas yog nws fab tshuaj tsis haum lossis tsis yog?
Tsis muaj leej twg muaj cuab kav teb tau cov lus nug hauv qhov tsis pom kev.
Hloov mus rau kev noj zaub mov kom tsis tshua muaj carb - http://endocrin-patient.com/dieta-pri-saharnom-diabete/ - tso cai rau koj kom txo tau cov tshuaj noj sai thiab ntev ntev ntawm 2-8 zaug. Ntawm lwm yam, nws txo qhov zaus thiab qhov mob ntawm kev ua xua.
mus hloov khoom noj thiab lwm yam
Qhov no tsis yog ntawm kev txiav txim siab raug, tab sis tsuas yog ib qho.
Nyob zoo Kuv ntawd nrhiav tau koj qhov chaw nthuav thiab txawv. Kuv yuav piav kuv qhov xwm txheej. Vam tias yuav paub koj lub tswvyim. Kuv yog 59 xyoo, qhov siab 162 cm, hnyav tshaj 8 xyoo dhau los, maj mam poob los ntawm 59 txog 53 kg. Ntshav qab zib Hom 2 tau tshawb pom los ntawm kev pheej hmoo 7 xyoo dhau los. Kho nrog tshuaj ntsiav. Tsuas yog xyoo no kuv tau pauv mus rau Levemir insulin ntawm 12 chav nyob rau ib hmo. Muaj cov neeg mob uas tsis muaj qab zib 2.2-3.0 thaum tsaus ntuj, yog li tus kws kho mob tshuaj xyuas qhov koob tshuaj thiab txo nws mus rau 8 pawg. Hauv cov tshuaj no, Kuv muaj qab zib zoo 4.8-6.8. Kuv tau mus ncig so rau sab qab teb - thiab nyob ntawd, rau qee qhov, cov piam thaj qib siab dua, txog 12-13, txawm tias kuv txuas ntxiv mus txhaj Levemir. Kuv tau rov qab los tsev - txhua yam rov qab los nyob li qub. Kuv sim Januvius ntsiav tshuaj - qab zib yam tsis muaj lawv thiab tawm tsam keeb kwm ntawm lawv qhov kev nqus yog tib yam. Nqe Lus Nug: Kuv puas yuav muaj ntshav qab zib hom 2? Thiab vim li cas kev so lub caij ntuj sov ua rau muaj kev cuam tshuam rau cov qab zib cov nqi ntau?
Kuv puas yuav muaj ntshav qab zib hom 2 no?
Tsis yog, koj tus kab mob hu ua LADA ntshav qab zib. Nws tsis zoo rau koj noj yam tshuaj. Koj yuav tsum ua raws li kev noj zaub mov kom tsawg thiab noj tshuaj insulin raws li xav tau.
vim li cas kev so lub caij ntuj sov muaj feem cuam tshuam rau cov nqi qab zib ntau?
Tej zaum vim tias cov kua dej overheated thaum lub sijhawm kev thauj mus los thiab qub.
Raws li txoj cai, so, thiab txawm nyob hauv qhov chaw sov, txhim kho cov ntshav qabzib, es tsis txhob txhawm rau lawv.
Muaj cov neeg mob uas tsis muaj qab zib 2.2-3.0 thaum tsaus ntuj, yog li tus kws kho mob tshuaj xyuas qhov koob tshuaj thiab txo nws mus rau 8 pawg
Koj yuav tsum tuaj yeem suav sau nws tus kheej tsim nyog cov tshuaj insulin. Pib los ntawm kev tshawb txog cov lus no - http://endocrin-patient.com/dozy-insulin-otvety/.
Nyob zoo Kuv yog 59 xyoo, qhov siab 182 cm, qhov hnyav 80 kg. Kuv tau raug tus mob ntshav qab zib hom 1 tau 29 xyoos. Ntawm insulin los ntawm thawj hnub ntawm tus kab mob. Lub sij hawm dhau los kuv nkaug ib qho lus qhia ntawm 14 chav rau khoom noj thiab Lantus 10 units nyob rau yav tsaus ntuj. Yuam kom pauv mus rau Tujeo. Thawj cov koob txhaj tau siv nrog tas li dhia qab zib mus txog 20, tua nrog insulin luv. Rho nws mus txog 10 units. Nws rov qab mus rau Lantus - txhua yam rov zoo li qub. Thaum lub lantus xaus lawm, nws hloov mus rau tujeo. Lub cev tawm tsam kuv. Qab zib dhia hauv 20, liab me ntsis, xws li dermatitis, nrog khaus mus thoob plaws lub cev. Kuv yuav lantus - Kuv nkag mus rau lub xeev dhau los. Vim tias tsis muaj lub lantus, cov lvemir tau muab tawm. Lo lus nug: dab tsi yog nws nrog kuv? Yuav ua li cas nkaug levemir?
Ntau tus neeg mob ntshav qab zib yws cov kev mob tshwm sim tom qab hloov mus rau tujeo
Pib ntawm tib lub tshuaj li lantus. Tej zaum nws yuav tsim nyog los maj nce nws ntawm ob peb hnub. Qhov no yog tus kheej rau txhua tus neeg mob. Yuav tsis muaj qhov kwv yees meej ntawm no.
Nyob zoo Kuv pog muaj 72 xyoos, qhov siab 168 cm, hnyav 93 kg. Nws tau ntev tau raug kev txom nyem los ntawm hom 2 mob ntshav qab zib, tawm tsam ntawm kev mob hauv lub plawv, txog siav, thiab ntshav siab. Tau ntau xyoo nws tau noj tshuaj: carvedilol, torvacard, zilt, lerkamen, glucophage, thrombotic ass, ramipril, amlodipine. Ib hlis dhau los, lawv yaum kom nws pib txhaj cov tshuaj insulin levemir thiab tsum tsis txhob noj tshuaj manin. Ob peb hnub tom qab, o ntawm nws ob txhais ceg sib zog. Cov kws kho mob qhia pom kev ntsuas ntshav rau cov hlau. Nws qib tau txo qis. Veroshpiron, Britomar, thiab Ferro-Folgamma kuj tau raug tshaj tawm ntxiv, ntxiv rau cov uas teev rau saum no. Hauv qab ntawm cov tshuaj no, qhov o ploj mus, tab sis tam sim no nws yws ntawm xeev siab, qee zaum kiv taub hau. Cov ntshav qab zib tuav 9-12. Lo lus nug: yuav insulin ua rau o thiab xeev siab? Tej zaum qee cov tshuaj tsis tau sib txuas ua ke thiab muab cov kev mob tshwm sim? Ua tsaug ua ntej rau koj kev teb!
Ib hlis dhau los, lawv yaum kom nws pib txhaj cov tshuaj insulin levemir thiab tsum tsis txhob noj tshuaj manin.
Nws zoo dua yav dhau los. Nws tseem yog qhov tseem ceeb dab tsi uas pog noj. Nej ua twb zoo txaus lawm los txog qhov no.
insulin puas tuaj yeem ua kom o thiab xeev siab?
Tsis muaj - tsis muaj. O o - ua tau. Tab sis ib qho kev pheej hmoo ntxiv yog plawv nres, uas yog maj mam tsim.
Tej zaum qee cov tshuaj tsis tau sib txuas ua ke thiab muab cov kev mob tshwm sim?
Koj tus niam pog yuav noj tag nrho cov tshuaj tua kab. Tej zaum nws tseem muaj sia nyob tsuas yog vim qhov no. Hauv nws qhov teeb meem, cov tshuaj noj rau ntau xyoo xyov hloov txoj kev txij nkawm ua lub neej noj qab nyob zoo.
Txhawm rau kom tshem tawm ib hom tshuaj twg, kom txo qhov muab tshuaj yog muaj peev xwm tsuas yog pom zoo nrog tus kws kho mob, thiab tsis nyob hauv kev siv tus kheej. Kuv xav sab laj nrog kws kho mob seb nws puas tuaj yeem tshem tawm Britomar, thiab tshwj xeeb tshaj yog Zilt, yog tias tsis muaj mob plawv. Lerkamen thiab ramipril koom nrog tib chav kawm ntawm cov tshuaj. Lawv twv yuav raug hu yuav tsum tsis txhob coj tib lub sijhawm.
Ib tsab xov xwm hais txog kev kho mob ntshav qab zib rau cov laus yuav los txog - http://endocrin-patient.com/diabet-pozhilych-ludej/
Kuv muaj hnub nyoog 71 xyoo, qhov siab 170 cm, hnyav 75 kg. Mob ntshav qab zib txij li xyoo 1994, glycated hemoglobin 6.5%. Kuv ua cov tshuaj ntxuav ntshav muaj roj 3-4 chav nyob rau ib pluas, thaum tsaus ntuj 16 chav nyob thiab metformin 1000 mg. Vim tias tsis muaj qhov muag teeb ntawm lub tsev muag tshuaj, Kuv hloov pauv rau lub ntsej muag kom zoo. Qhia rau kuv xaiv cov tshuaj ntau npaum li cas, pes tsawg koob tshuaj.Puas tsim nyog sim tujo? Muaj qhov ntsuas tsis zoo txog nws.
Qhia rau kuv xaiv cov tshuaj ntau npaum li cas, pes tsawg koob tshuaj.
Pib nrog tib qho koob tshuaj thiab cov sij hawm txhaj tshuaj raws li rau Lantus, thiab tom qab ntawd nws yuav pom.
Puas tsim nyog sim tujo? Muaj qhov ntsuas tsis zoo txog nws.
Ua ntej tshaj plaws, sim tsim kom muaj kev tswj hwm koj tus kab mob ntshav qab zib nrog Levemir insulin, thiab tseem ceeb tshaj plaws, hloov mus rau kev noj haus kom tsawg. Thiab tsuas yog tias Levemir tsis haum, sim Tujeo, thiab nyiam Treshiba.
Daim ntawv noj tshuaj:
Tshuaj Subcutaneous
1 ml ntawm cov tshuaj muaj:
yam tshuaj: insulin detemir - 100 PHOO,
tus zam: glycerol, phenol, metacresol, zinc acetate, sodium hydrogen phosphate dihydrate, sodium chloride, hydrochloric acid los yog sodium hydroxide, dej rau kev txhaj tshuaj.
Ib qho cartridge muaj 3 ml ntawm kev daws, sib npaug rau 300 daim PIECES. Ib chav tsev ntawm insulin detemir muaj 0.142 mg ntawm cov ntsev tsis muaj tshuaj tua kab mob insulin. Ib koog ntawm insulin detemir (ED) sib raug rau ib koog ntawm tib neeg cov insulin (ME).
Kev piav qhia
Cov kua roj ntshiab thiab tsis muaj xim.
Qhia me ntsis
Levemir yog lub hlwb ntawm lub tuam txhab Danish Novo Nordisk, paub txog nws cov kev kho mob ntshav qab zib. Cov tshuaj tau dhau los ntawm kev tshawb fawb ntau yam, suav nrog menyuam yaus thiab cov hluas, thaum cev xeeb tub. Txhua tus ntawm lawv tau lees paub tsis tsuas yog kev nyab xeeb ntawm Levemir, tab sis kuj tseem muaj txiaj ntsig ntau dua li siv insulins yav dhau los. Kev tswj xyuas piam thaj muaj txiaj ntsig ib yam li cov ntshav qab zib hom 1 thiab hauv cov kev mob xav tau qis dua: hom 2 thaum pib siv tshuaj tua kab mob ntshav qab zib thiab mob ntshav qab zib hauv lub plab.
Cov lus qhia luv luv txog cov tshuaj los ntawm cov lus qhia rau kev siv:
| Kev piav qhia | Cov xim tsis muaj kob uas muaj qhov tsis txaus ntawm U100, ntim rau hauv daim iav cartridges (Levemir Penfill) lossis cov xaum xaum uas tsis tas yuav ntim khoom (Levemir Flexpen). |
| Muaj pes tsawg leeg | Lub npe thoob ntiaj teb uas tsis yog tus tswv lag luam rau cov nquag muaj ntawm Levemir (INN) yog insulin detemir. Ntxiv nrog rau nws, cov tshuaj muaj excipients. Txhua qhov sib xyaw ua ke tau kuaj xyuas tus mob toxicity thiab carcinogenicity. |
| Cov Tshuaj Hauv Tshuaj | Tso cai rau koj kom ntseeg siab rau qhov kev tso tawm ntawm cov kua dej hauv paus. Nws muaj qhov txawv txav tsawg, uas yog, cov nyhuv tsis txawv me ntsis hauv ib tus neeg mob ntshav qab zib nyob rau ntau hnub sib txawv, tab sis kuj nyob rau lwm tus neeg mob. Kev siv cov tshuaj insulin Levemir txo qis kev pheej hmoo ntawm kev mob ntshav qab zib, txhim kho lawv txoj kev paub. Cov tshuaj no tam sim no tsuas yog "qhov hnyav-nruab nrab" insulin, nws zoo dua cuam tshuam rau lub cev qhov hnyav, ua kom nrawm zoo li qhov pom kev zoo nkaus. |
| Cov yam ntxwv ntawm kev nqus | |
| Cov Khoom Qhia | Txhua hom ntshav qab zib xav tau kho cov tshuaj insulin rau cov nyiaj them zoo. Levemir zoo tib yam nkaus rau menyuam yaus, hluas thiab cov neeg laus, tuaj yeem siv rau kev ua txhaum ntawm daim siab thiab lub raum. Nrog ntshav qab zib hom 2, nws siv nrog rau cov kab mob hypoglycemic yog tso cai. |
| Cov Yuav Tsum Muaj | Levemir yuav tsum tsis txhob siv:
Cov tshuaj yog muab tsuas yog subcutaneously, kev tswj hwm dej num yog txwv tsis pub. Kev tshawb fawb ntawm cov menyuam yaus hauv qab ob xyoos tsis tau nqis tes ua, yog li hom kab mob ntawm cov neeg mob no tseem tau hais hauv contraindications. Txawm li cas los xij, cov insulin no raug muab rau cov menyuam tseem yau. |
| Cov lus qhia tshwj xeeb | |
| Tsuas tshuaj | |
| Cia | Levemir, zoo li lwm yam insulins, yuav tsum muaj kev tiv thaiv los ntawm lub teeb, khov thiab overheating. Lub rooj npaj tsis zoo yuav tsis txawv nyob rau hauv txhua txoj kev los ntawm ib qho tshiab, yog li tshwj xeeb yuav tsum tau them rau cov kev mob cia. Qhib cov roj cartridges tau li 6 lub lim tiam thaum sov li chav nyob. Cov fwj dej khib nyiab yog cia rau hauv tub yees, lawv lub neej txee txij li hnub ntawm kev tsim khoom yog 30 hli. |
| Nqi | 5 daim cartridges ntawm 3 ml (tag nrho 1,500 units) ntawm Levemir Penfill tus nqi los ntawm 2800 rubles. Tus nqi ntawm Levemir Flexpen yog me ntsis dua. |
Qhov kev ua ntawm insulin levemir yog dab tsi
Levemir yog insulin ntev ntev. Nws cov nyhuv yog ntev dua li cov tshuaj ib txwm muaj - sib xyaw ntawm tib neeg cov tshuaj insulin thiab tshuaj tiv thaiv. Ntawm ib koob tshuaj ntawm txog 0.3 units. ib kilogram, cov tshuaj ua haujlwm 24 teev. Cov me dua qhov yuav tsum tau muab cov tshuaj, lub sijhawm ua haujlwm luv luv. Hauv cov neeg mob ntshav qab zib, tom qab cov zaub mov tsis muaj carb, qhov kev txiav txim yuav xaus tom qab 14 teev.
Cov tshuaj insulin ntev ntev tsis tuaj yeem siv los kho txhim kho glycemia thaum nruab hnub lossis thaum mus pw. Yog tias pom cov piam thaj kom tsawg nyob rau yav tsaus ntuj, nws yog qhov tsim nyog yuav tau ua kom qhov kev txhaj tshuaj tiv thaiv luv luv ntawm cov tshuaj insulin, thiab tom qab nws los qhia qhov ntev ntawm cov tshuaj hormones hauv tib lub tshuaj. Koj tsis tuaj yeem muab cov tshuaj insulin sib xyaw ntawm cov tshuaj sib txawv hauv tib cov koob txhaj.
Tso Tawm Cov Ntawv
Levemir insulin hauv lub vial
Levemir Flexpen thiab Penfill sib txawv tsuas yog hauv daim ntawv, cov tshuaj hauv lawv zoo ib yam. Penfill - cov no yog cov cartridges uas tuaj yeem tso rau hauv cov xaum xaum los yog hom insulin los ntawm lawv nrog tus qauv insulin koob txhaj tshuaj. Levemir Flexpen - ua ntej ntim los ntawm cov chaw tsim tshuaj paus koob txhaj tshuaj uas siv kom txog thaum kev daws teeb meem tag. Koj tsis tuaj yeem rov nruab lawv dua. Cwjmem tso cai rau koj kom nkag mus rau cov tshuaj insulin hauv qhov nce ntxiv ntawm 1 pawg. Lawv yuav tsum tau yuav nyias NovoFayn koob. Ua raws li cov tuab ntawm subcutaneous ntaub so ntswg, tshwj xeeb tshaj yog nyias (0.25 mm inch) 6 hli ntev lossis nyias (0.3 hli) 8 hli yog xaiv. Tus nqi ntawm ib pob ntawm 100 koob yog li 700 rubles.
Levemir Flexpen yog qhov tsim nyog rau cov neeg mob ua lub neej nquag thiab tsis muaj sijhawm. Yog tias qhov xav tau rau cov tshuaj insulin yog ib qho me me, ib theem ntawm 1 chav tsev yuav tsis tso cai rau koj hu rau qhov koob uas xav tau. Rau cov neeg zoo li no, Levemir Penfill raug pom zoo kom ua ke nrog cov xaum xaum uas raug dua, piv txwv li NovoPen Echo.
Cov tshuaj kom raug
Qhov koob tshuaj ntawm Levemir yog suav tias yog yog tias tsis tsuas yoo suab thaj, tab sis kuj glycated hemoglobin nyob rau hauv ib txwm muaj. Yog tias them nyiaj rau ntshav qab zib tsis txaus, koj tuaj yeem hloov cov tshuaj insulin ntev ntev txhua 3 hnub. Txhawm rau txiav txim siab kho qhov tsim nyog, cov neeg tsim khoom pom zoo kom noj qab zib nruab nrab ntawm lub plab khoob, 3 hnub tas los yog koom nrog hauv qhov muab xam
| Glycemia, mmol / l | Koob hloov | Kev hloov kho tus nqi, ntsuas |
| 10 | 10 |
Cov sijhawm txhaj tshuaj
- Nrog ntshav qab zib hom 1 cov kev qhia tau pom zoo kom tswj hwm cov tshuaj insulin ob zaug: tom qab sawv thiab ua ntej yuav mus pw. Cov txheej txheem zoo li no muab cov nyiaj zoo dua los kho cov ntshav qab zib ntau dua li ib qho. Koob tshuaj yog suav nyias. Txog rau cov tshuaj insulin thaum sawv ntxov - raws li kev siv yoo qab zib txhua hnub, rau yav tsaus ntuj - raws nws cov nuj nqis txhua hmo.
- Nrog ntshav qab zib hom 2 ob qho tib si thiab ob chav thawj coj yog qhov ua tau. Cov kev tshawb fawb qhia pom tias thaum pib cov tshuaj insulin, ib qho kev txhaj tshuaj ib hnub twg yog qhov txaus kom ua tiav cov phiaj yam suab thaj. Kev noj tshuaj ib zaug ib leeg tsis tas yuav nce ntxiv hauv cov koob tshuaj suav. Nrog rau tus mob ntshav qab zib ntev mellitus, cov tshuaj insulin ntev dua yog qhov xav paub ntau tshaj los tswj ob zaug ib hnub.
Siv rau menyuam yaus
Txhawm rau tso cai rau kev siv Levemir hauv ntau pab pawg neeg, yuav tsum muaj kev tshawb fawb loj nrog cov neeg ua haujlwm pab dawb. Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, qhov no cuam tshuam nrog ntau yam nyuaj, yog li ntawd, hauv cov lus qhia rau kev siv, muaj hnub nyoog txwv. Ib qho xwm txheej zoo sib xws nrog lwm cov insulins niaj hnub. Dua li ntawm qhov no, Levemir tau ua tiav zoo hauv cov menyuam yaus txog li ib xyoos. Txoj kev kho nrog lawv yog qhov ua tau zoo ib yam li cov me nyuam hlob. Raws li cov niam txiv, tsis muaj dab tsi zoo.
Hloov mus rau Levemir nrog NPH insulin yog qhov tsim nyog yog tias:
- yoo suab thaj tsis ruaj khov,
- Kev mob ntshav qog ntshav yog pom thaum hmo ntuj lossis yav tsaus ntuj,
- tus me nyuam yog thawj.
Sib piv ntawm Levemir thiab NPH-insulin
Tsis zoo li Levemir, tag nrho cov insulin nrog protamine (Protafan, Humulin NPH thiab lawv cov lus piv txwv) muaj cov txiaj ntsig tshaj plaws, uas ua rau muaj kev pheej hmoo ntawm hypoglycemia, ntshav qab zib jumps tshwm sim thawm hnub.
Pov Thawj Cov txiaj ntsig Levemir:
- Nws muaj qhov ua kom paub tseeb dua.
- Txo qhov tshwm sim ntawm kev txo tus kabmob ntshav qab zib: mob hnyav 69%, hmo ntuj tau 46%.
- Nws ua rau cov hnyav dua hauv cov ntshav qab zib hom 2: hauv 26 lub lis piam, qhov hnyav hauv cov neeg mob ntawm Levemir nce ntxiv los ntawm 1.2 phaus, thiab hauv cov neeg mob ntshav qab zib ntawm NPH-insulin los ntawm 2.8 kg.
- Nws tswj kev tshaib kev nqhis, uas ua rau kev poob qab los noj mov hauv cov neeg mob rog rog. Tus mob ntshav qab zib hauv Levemir noj thaj tsam li 160 kcal / hnub tsawg dua.
- Nce zais ntawm GLP-1. Nrog ntshav qab zib hom 2, qhov no ua rau muaj kev sib txuas ntxiv ntawm lawv tus kheej insulin.
- Nws muaj cov txiaj ntsig zoo ntawm dej-ntsev dej metabolism, uas txo cov kev pheej hmoo ntawm tawg.
Tib qho kev tsis zoo ntawm Levemir hauv kev sib piv nrog NPH npaj tau yog nws tus nqi siab. Xyoo tsis ntev los no, nws tau muaj nyob rau hauv cov npe ntawm cov tshuaj tseem ceeb, yog li cov neeg mob ntshav qab zib tuaj yeem tau txais nws dawb.
Levemir yog cov tshuaj insulin tshiab, yog li nws tsis muaj qhov pheej yig generics. Qhov ze tshaj plaws hauv cov khoom thiab lub sijhawm ntawm kev nqis tes yog cov tshuaj los ntawm cov pab pawg ntawm ntev insulin analogues - Lantus thiab Tujeo. Hloov mus rau lwm lub tshuaj insulin yuav tsum tau noj tshuaj kom rov zoo dua thiab ua qee yam ua rau muaj kev cuam tshuam me ntsis hauv kev them nyiaj rau cov ntshav qab zib mellitus, yog li, cov tshuaj yuav tsum hloov pauv rau kev kho mob nkaus xwb, piv txwv li, nrog tus neeg tsis kam txais.
Levemir lossis Lantus - uas zoo dua
Cov chaw tsim khoom tau nthuav tawm qhov zoo ntawm Levemir hauv kev sib piv nrog nws cov neeg sib tw loj - Lantus, uas nws zoo siab tau qhia hauv cov lus qhia:
Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm lub koom haum ntawm Diabetology - Tatyana Yakovleva
Kuv tau kawm mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.
Kuv maj nrawm los qhia txoj xov zoo - Endocrinological qhov chaw tshawb fawb ntawm Lavxias Academy ntawm Medical Science tau tswj hwm los tsim cov tshuaj uas kho cov mob ntshav qab zib mellitus kom zoo. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.
Lwm qhov xov xwm zoo: Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau txais kev nyab xeeb qhov kev saws me nyuam ntawm cov haujlwm tshwj xeeb uas them rau cov nqi tshuaj ntau. Hauv Lavxias, neeg mob ntshav qab zib kom txog thaum lub Tsib Hlis 18 (suav nrog) tuaj yeem tau txais nws - Tsuas yog 147 rubles!
- qhov kev txiav txim ntawm cov kua dej yog qhov ntxiv tas mus li
- cov tshuaj muab kom hnyav ntxiv.
Raws li kev txheeb xyuas, cov kev sib txawv no yuav luag pom tsis tau, yog li cov neeg mob nyiam siv tshuaj, cov tshuaj uas yooj yim rau hauv thaj av no.
Qhov txawv tsuas yog qhov tseem ceeb rau cov neeg mob uas ntxuav cov kua dej: Levemir sib xyaw zoo nrog kua ntsev, thiab Lantus qee qhov poob nws cov khoom thaum diluted.
Cov Tshuaj Tiv Thaiv:
Siv thaum cev xeeb tub thiab pub niam mis
Cev xeeb tub
Thaum siv Levemir ® Penfill ® thaum cev xeeb tub, nws yog ib qho tsim nyog yuav tsum xav txog ntau npaum li cas cov kev siv ntawm nws siv ntau dua qhov ua tau pheej hmoo.
Ib qho kev soj ntsuam mob sib xyaw nrog cov poj niam cev xeeb tub uas muaj hom 1 mob ntshav qab zib mellitus, uas tau kawm txog kev ua tau zoo thiab kev nyab xeeb ntawm kev sib xyaw ua ke nrog Levemir ® Penfill ® nrog insulin aspart (152 tus poj niam cev xeeb tub) piv nrog isofan-insulin nrog insulin aspart. (158 tus poj niam cev xeeb tub), tsis qhia txog qhov sib txawv ntawm qhov muaj feem nyab xeeb rau lub sijhawm muaj menyuam hauv plab, hauv kev tshwm sim cev xeeb tub, lossis kev noj qab haus huv ntawm tus menyuam hauv plab thiab cov menyuam yug tshiab (saib ntu “
Sab sij huam:
Cov kev tsis zoo tshwm sim pom hauv cov neeg mob siv Levemir ® Penfill mainly feem ntau yog koob tshuaj thiab tsim kho vim yog cov tshuaj pharmacological zoo ntawm cov tshuaj insulin. Kev mob ntshav qab zib feem ntau yog cov kev mob tshwm sim feem ntau. Kev mob ntshav qab zib yog nce zuj zus yog tias noj tshuaj ntau dhau yog siv rau ntawm lub cev xav tau cov tshuaj insulin. Los ntawm cov kev tshawb fawb hauv chaw kho mob nws tau paub tias mob ntshav qab zib ntau yam uas yuav tsum muaj kev cuam tshuam ntawm cov neeg thib peb hauv kwv yees li 6% ntawm cov neeg mob tau txais Levemir ® Penfill ®.
Cov tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj tuaj yeem pom ntau zaus nrog Levemir ® Penfill ® tshaj li kev qhia ntawm tib neeg insulin. Cov kev cuam tshuam no suav nrog liab, o, ua pob, ua pob, thiab khaus ntawm qhov chaw txhaj tshuaj. Feem ntau qhov tshwm sim ntawm qhov chaw txhaj tshuaj yog qhov me me thiab ib ntus ntawm qhov xwm txheej, i.e. ploj nrog kev kho mob txuas mus ob peb hnub mus rau ntau lub lis piam.
Qhov feem ntawm cov neeg mob uas tau txais kev kho mob thiab uas cia siab tias yuav muaj kev mob tshwm sim yog kwv yees li 12%. Qhov tshwm sim ntawm cov kev mob tshwm sim, uas feem ntau kwv yees muaj feem xyuam nrog Levemir ® Penfill ®, thaum kuaj mob, raug nthuav tawm hauv qab no.
Kev tsis haum xeeb thiab zaub mov kev noj haus
Nquag (> 1/100, 1/100, 1/1 000, 1/1 000, 1/1 000, 1/10 000, ® Penfill ®, tuaj yeem ua rau kev puas tsuaj ntawm insulin detemir. Levemir ® Penfill ® yuav tsum tsis txhob ntxiv rau txoj kev lis ntshav. ntsiab.
Cov lus qhia tshwj xeeb
Kev cuam tshuam rau lub peev xwm tsav tsheb thiab ua haujlwm nrog cov txheej txheem
Lub peev xwm ntawm cov neeg mob kom pom tseeb thiab tus nqi tshuaj tiv thaiv tej zaum yuav raug mob vim tias ntshav nce qis, uas tuaj yeem ua rau muaj xwm txheej nyob rau hauv cov xwm txheej uas cov peev xwm no tsim nyog tshwj xeeb (piv txwv li, thaum tsav tsheb lossis ua haujlwm nrog cov tshuab thiab tshuab). Cov neeg mob yuav tsum tau qhia rau kev ntsuas kom tiv thaiv kev txhim kho hypoglycemia thaum tsav tsheb thiab ua haujlwm nrog cov txheej txheem. Qhov no tseem ceeb tshwj xeeb tshaj yog rau cov neeg mob uas tsis muaj los yog tsawg dua cov tsos mob ntawm kev tsim kho tus mob hypoglycemia lossis raug mob los ntawm kev pheej muaj ntshav ntau ntawm cov ntshav siab. Hauv cov xwm txheej no, kev tsim nyog ntawm kev tsav tsheb los yog kev ua haujlwm zoo li no yuav tsum raug txiav txim siab.
Daim ntawv tso tawm:
Ib qho kev daws teeb meem rau kev coj ua subcutaneous ntawm 100 PIECES / ml.
3 ml txhua nyob rau hauv lub khob iav ntawm hydrolytic chav kawm 1, ntim nrog bromobutyl roj hmab cuam ntawm ib sab thiab bromobutyl roj hmab pistons ntawm lwm yam. 5 cartridges ib lub hlwv ntawm PVC / txhuas ntawv ci. 1 blister ua ke nrog cov lus qhia rau kev siv rau hauv thawv ntawv thawv.
