Simvastol: cov lus qhia rau kev siv, analogues, nqe, tshuaj xyuas

Cov tshuaj tsis tsaug zog. lactonecuam ​​tshuam txog cov khoom cua sib deev Aspergillus terreusCov. Hauv cov txheej txheem ntawm cov metabolism, hydroxy acid derivative yog tsim los uas inhibits HMG-CoA reductasecatalyzing qhov pib ntawm kev tsim mevalonatekoom tes nrog thawj theem ntawm synthesis rojCov. Tib lub sijhawm, kev noj tshuaj tsis nrog ua ke los ntawm kev txuam nrog hauv lub cev sterolsCov. Nyob rau hauv lub hwj simvastatin lub cev qib qis dua lipoprotein tsawg ntom ntom triglycerides thiab feem ntau rojCov. Nyob rau tib lub sijhawm, qib nce ntxiv lipoprotein high ntom. Cov nyhuv hauv feem ntau ntawm cov neeg mob nws tus kheej tau tshwm sim tom qab 10-14 hnub txij li kev pib ua haujlwm thiab nce mus txog qhov siab kawg tom qab 1-1.5 lub hlis. Tom qab noj cov tshuaj roj rov los rau nws qib qub dhau.

Cov Tshuaj Pharmacokinetics

Simvastatin nws yog zoo nqus, qhov siab tshaj plaws nyob rau hauv cov ntshav tau pom ntawm nruab nrab tom qab ob teev. Siab sib txuas nrog cov protein ntshav - txog 95%. Hloov hauv daim siab ua haujlwm beta hydroxyl kua qaubnrog kev ua haujlwm pharmacological siab. Kev tshem tawm ib nrab-lub neej ntawm metabolites yog li ob teev. Nws yog tawm raws li cov khoom noj metabolites los ntawm txoj hnyuv thiab ua kom qis qis los ntawm lub raum.

Kev ntsuas rau siv

• Hypercholesterolemia: IIa thiab IIb hom thawj hypercholesterolemia thaum tsis muaj kev cuam tshuam ntawm kev noj cov zaub mov cholesterol tsawg thiab tsis ntsuas tshuaj (poob phaus, kev tawm dag zog) hauv cov neeg mob uas muaj kev pheej hmoo atherosclerosis kev sib xyaw ua ke ntawm lub siab, tsis kho los ntawm kev noj haus thiab qoj ib ce hypertriglyceridemia thiab hypercholesterolemia,
• Coronary mob plawv: kom txo tau txoj kev pheej hmoo tuag tom qab myocardial infarction, los txo cov kev pheej hmoo ntawm kev txhim kho kev cuam tshuam ntawm cov hlab plawv (mob stroke), qeeb me ntsis ntawm cov txheej txheem tsim kho atherosclerosis hlab ntshav hlab.

Cov Yuav Tsum Muaj

Siab rhiab heev rau cov tshuaj, mob hlwbdaim siab mob cev xeeb tub, hnub nyoog txog 18 xyoo. Siv nrog ceev faj hauv cov neeg mob nrog arterial hypotensionntawm qaug dab pegtom qab noj txhaj tshuaj tiv thaiv kab mobnrog mob ntev quav cawvcov mob sib kis ceev, nrog kev ua txhaum ntawm cov dej-electrolyte sib npaug, tom qab raug mob lossis phais mob.

Sab sij huam

Xeev siab, ntuav, mob plab, flatulence, zawv plabcem quav pancreatitis, kab mob siab, kiv taub hau, mob taub haucov leeg cramps, asthenic syndrome, insomnia, paresthesia, tshuaj mob hlwbsaj ua txhaum, myalgiacov leeg tsis muaj zog pob ib leeg photosensitization, eosinophiliakev tsa ESR, thrombocytopeniakev fab tshuaj tsis haum anemia, tsawg potency, yaug ntawm daim tawv nqaij, palpitations.

Simvastol, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Kev kho mob nrog cov tshuaj yuav tsum tau ua tawm ntawm keeb kwm ntawm kev teem caij mus rau tus neeg mob hypocholesterol noj cov zaub movCov. Simvastol ntsiav tshuaj yuav tsum noj 1 zaug nyob rau ib hnub, yam tsis muaj kev sib txuas nrog kev noj zaub mov, zoo dua rau yav tsaus ntuj, ntxuav tawm nrog dej.

Kev Kho Mob hypercholesterolemia - cov koob tshuaj thawj zaug yog 10 mg thiab yav tom ntej, kev xaiv koob tshuaj yuav tsum tau ua txhua txhua 4 asthiv. cov txiaj ntsig zoo tshaj plaws yog pom nyob hauv cov neeg mob uas tau txhaj ntau txog 20 mg / hnub. Qhov kev txhaj tshuaj ntau tshaj plaws hauv ib hnub yuav tsum tsis pub ntau tshaj 80 mg.

Kho cov neeg mob nrog Ischemic mob plawv - Kev siv tshuaj zoo heev yog 20-40 mg / hnub. Kev hloov koob tshuaj yog ua tiav txhua hli; raws li kev qhia, qhov tshuaj yuav nce ntxiv txog 40 mg ib hnub twg. Cov laus thiab cov neeg mob nrog lub raum tsis ua hauj lwm cov kev kho kom haum los sib haum yog tsis ua.

Kev Sau ua ke, daim foos tso tawm

Simvastol tsuas muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj uas muaj kev sib txawv simvastatin - 10, 20 lossis 40 milligrams. Lawv yog cov puag ncig, nrog convex nto, dawb ntxhais. Sab nraum cov ntsiav tshuaj yog coated, xim ntawm cov uas rau cov sib txawv tshuaj sib txawv:

• 10 mg liab
• 20 mg - daj
• 40 mg yog xim av.

Simvastol raug tso tawm los ntawm cov tshuaj simvastatin, uas yog tib yam tshuaj ntawm lub tshuaj. Cov khoom siv ntxiv muab cov huab hwm coj, txhim kho kev nqus, ua rau lub sijhawm ntev cia. Cov no yog cov kua qaub citric thiab ascorbic, kua mis qab zib, microcrystalline cellulose PH101, magnesium stearate, butylhydroxyanisole. Rau lub khauj khaum, cov khw tsim cov tshuaj Opadray II txheej, qhov muaj pes tsawg leeg rau qhov sib txawv tshuaj sib txawv hauv cov dyes.

Pharmacological kev txiav txim

Simvastol ntsiav tshuaj tau cais raws li cov tshuaj tiv thaiv tshwj xeeb ntawm HMG-CoA reductase. Qhov no txhais tau hais tias nws txoj kev ua haujlwm nquag, simvastatin, cuam tshuam nrog ib yam khoom uas tau hais tseg. Hauv qhov no, lub enzyme HMG-CoA reductase. Raws li cov lus qhia, txhua yam cuam tshuam los ntawm kev noj tshuaj yog qhov tshwm sim ntawm kev thaiv ib qho tshuaj lom neeg. HMG-CoA reductase enzyme yuav tsum pib ib theem pib ntawm cov roj (synthesis) roj. Muaj cov qauv zoo sib xws, simvastatin suav nrog hauv cov saw hlau ntawm tshuaj lom neeg kev hloov pauv hloov tawm ntawm cov enzyme. Tab sis vim tias nws cov lus sib txawv tsis sib xws, cov txheej txheem ntawm cov roj cholesterol tsim tsis mus ntxiv dua li cov tshuaj tiv thaiv no. Kev Tsis Siv HMG-CoA reductase tawg rau acetyl-CoA, cov khoom uas lub cev siv los tsim lub zog thiab ntau dua.

Kev thaiv ib qho kev sib pauv ib leeg ua rau muaj kev pauv hloov pauv hauv cov roj ntau. Ua ntej tshaj plaws, theem ntawm tag nrho cov roj (OH) poob. Hauv kev teb rau qhov txo qis hauv nws cov theem, cov ntsiab lus ntawm qis, qis qis heev lipoproteins (LDL, VLDL), cov roj ntsha nruab nrab triglyceride rog (TG) tsawg dua. Ib qho kev ua haujlwm siab ntawm cov metabolites ntawm cov rog metabolism ua rau qhov tsim ntawm qhov tso nyiaj rau ntawm cov hlab ntsha. Yog li pib txoj kev loj hlob ntawm atherosclerosis. Thawj cov quav hniav tuaj yeem ua kom me me, tsis muaj kev phom sij rau kev noj qab haus huv. Raws li nws loj hlob zuj zus tuaj, lub lumen ntawm lub nkoj nqaim, nce mus txog nws qhov kev thaiv tag nrho. Qhov phom sij tshwj xeeb yog qhov tsis zoo rau lub nkoj ntawm lub plawv. Yog tias qee qhov ntawm nws poob nws cov ntshav ncig, nws lub hlwb tuag - myocardial infarction kev loj hlob.

Tab sis muaj cov lipoproteins "zoo" hauv lub cev - HDL. Lawv pab tswj cov rog los ntawm phab ntsa ntawm cov hlab ntsha. Kev siv cov simvastol pab txhim kho lawv cov kev xav. Ntxiv rau qhov kev loj hlob tsis, nws txo qhov feem ntawm LDL / HDL, OH / HDL. Txhua yam kev hloov pauv no muaj cov txiaj ntsig zoo los txo qis kev pheej hmoo ntawm lub plawv.

Simvastatin yog yaim sai sai hauv txoj hnyuv. Tom qab 1.3-2.4 teev, qhov siab tshaj plaws tau sau tseg. Thawj qhov tshwm sim ntawm kev siv Simvastol yog sau tom qab 2 lub lis piam. Kev soj ntsuam ntawm kev ua haujlwm yog nqa tawm tom qab 4-6 lub lis piam txij li hnub pib, thaum muaj kev ua haujlwm ntawm cov tshuaj nce mus txog nws qhov siab tshaj plaws. Rau qhov no, tus neeg mob pub ntshav rau kev soj ntsuam.

Simvastol: kev taw qhia rau kev siv

Kev qhia ntawm Simvastol pom zoo kom muab tshuaj rau kev kho mob ntawm hypercholesterolemia, yog tias cov roj (cholesterol) tsis tuaj yeem tau txais los ntawm kev noj haus, kev tawm dag zog. Qhov no siv rau ob qho tib si nrhiav thiab congenital (tsev neeg hypercholesterolemia) cuam tshuam ntawm cov metabolism hauv cov rog.

Simvastol ntsiav tshuaj tau siv rau hauv kev tiv thaiv cov hlab plawv pathologies, uas tau ua raws li kev tsim cov tshuaj atherosclerotic plaques. Ntawm kev pheej hmoo yog cov neeg muaj mob plawv, mob ntshav qab zib. Hauv cov pab pawg neeg no, cov tshuaj yuav txo tau:

• kev tuag los ntawm concomitant vascular pathologies,
• kev pheej hmoo ntawm lub plawv nres, mob hlab ntsha tawg,
• qhov xav tau kom povtseg rau txoj kev txiav ntshav qab zib,
• mob rau cov hlab ntshav mob atherosclerosis mob,
• kev pheej hmoo ntawm kev phais mob txha caj qaum.

Txoj kev ntawm daim ntawv thov, ntau npaum li cas

Ua ntej kev teem caij ntawm Simvastol, tus neeg mob yauv mus rau kev noj haus kom txo tau cov roj (cholesterol). Yog tias nws tsis nqa qhov txiaj ntsig uas xav tau, ib cov tshuaj tawm los. Nws ua txoj haujlwm pabcuam. Yog li, kev siv Simvastol yam tsis muaj kev noj haus yog qhov tsis muaj zog.

Cov zaub mov tsis cuam tshuam rau qhov nqus ntawm simvastatin. Yog li, kev noj tshuaj tsis tuaj yeem cuam tshuam nrog cov zaub mov. Simvastol ntsiav tshuaj noj rau sab hauv, ib hnub ib zaug, thaum yav tsaus ntuj.

Kev kho mob pib nrog kev noj tshuaj tsawg kawg, suav mus rau hauv cov kab mob concomitant, tus mob ntawm tus neeg mob, cov tshuaj uas nws noj. Ib zaug txhua 4 lub lis piam lossis luv dua, tus kws kho mob txheeb xyuas qhov muaj zog ntawm tus kab mob. Yog tias tsim nyog, hloov kho koob tshuaj. Lub sijhawm kho nrog Simvastol yog tus neeg thiab txiav txim los ntawm tus kws kho mob.

Hauv kev kho mob ntawm hypercholesterolemia, cov tshuaj yog coj hauv qhov ntau npaum li 10 txog 80 mg. Nws raug nquahu kom pib kho nrog 10 mg, maj mam nce ntxiv raws li tau piav qhia saum toj no. Rau feem ntau cov neeg mob, cov koob tshuaj zoo tshaj yog 20 mg.

Nrog rau cov keeb kwm caj ces ntawm cov roj (metabolism) cov ntshav tsis sib haum, koob tshuaj txhua hnub yog 40 mg ib zaug lossis 80 mg hauv peb faib peb zaug (20 mg ib zaug thaum sawv ntxov, tav su thiab 30 yav tsaus ntuj).

Kev siv cov Simvastol rau kev kho mob ntawm cov hlab plawv yog qhov muaj txiaj ntsig ntawm kev siv 20-40 mg / hnub. Cov lus qhia tswv yim pom zoo pib nrog 20 mg.

Hauv kev mob raum ntau, kev kho mob concomitant nrog danazol, vitamin B3 (≥1 g / hnub), cyclosporine, gemfibrozil, feem ntau cov fibrates txwv cov koob tshuaj niaj hnub ntawm Simvastol txog 10 mg. Cov neeg noj verapamil, amiodarone yuav tsum tsis txhob noj ntau tshaj 20 mg ntawm simvastatin.

Kev sib txuam

Qee cov tshuaj thaum siv ib txhij nrog Simvastol nce qhov kev pheej hmoo ntawm kev phiv tshuaj. Qee qhov ntawm no tau tso cai siv thaum txo cov tshuaj simvastatin. Peb tham txog lawv saum toj no.

Simvastol nrog cov muaj zog CYP3 A4 inhibitors yog contraindicated.

Tus nqi ntawm simvastol nyob ntawm ntau npaum cov, cov naj npawb ntawm cov ntsiav tshuaj hauv pob:

• 10 mg, 14 pcs. - 120-203 rub.,
• 10 mg, 28 pcs. - 118-230 rub.,
• 20 mg, 14 pcs. - 210 rubles.,
• 20 mg, 28 pcs. - 247-333 rub.

Cov tshuaj Analogues ntawm Simvastol nyob hauv cov khw muag tshuaj feem ntau hauv tebchaws Russia. Koj tuaj yeem nug tus kws muag tshuaj kom muaj cov tshuaj zoo li no: Simgal (Ixayees), Zorstat (Croatia), Simvor (Is Nrias teb), Avenkor (Russia), Holvasim (Kauslim) Wazilip (Slovenia), Sinkard (Is Nrias teb), Zokor (Netherlands), Simvalimit ( Latvia), Simvageksal (Lub Tebchaws Yelemees), Simvastatin (Russia). Tag nrho cov ntawm lawv muaj cov tshuaj nquag simvastatin.

Cov ntaub ntawv npaj los ntawm tus sau phau ntawv ntawm qhov project
raws li txoj cai kho ntaub ntawv ntawm lub xaib.

Muaj pes tsawg leeg thiab noj ntau npaum

Simvastol belongs rau cov pab pawg ntawm lipid-txo tshuaj. Nws lub hauv paus ua haujlwm tseem ceeb yog simvastatin, uas zwm rau chav kawm ntawm statins. Cov khoom siv ntxiv yog: lactose monohydrate, citric acid, ascorbic acid, lactose, glycerol, magnesium stearate.

Ib zaug hauv cov qe ntshav, cov tshuaj yeeb dej caw uas ua kom Simvastol maj mam txo qis cov roj "tsis zoo", thiaj li tiv thaiv kev tsim cov tshuaj sterols. Tsis tas li ntawd, cov tshuaj muaj peev xwm nce qib hauv qib "zoo" cov roj (cholesterol).

Nws yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj daj. Cov tshuaj muaj lub puab puag ncig, them nrog lub khaus ntsej muag daj zoo nkauj nrog lub ntsej muag zoo. Hauv seem ntev, ob txheej tau pom meej meej: dawb hauv, thiab daj ntawm sawv.

Qhov ntau npaum li cas ntawm cov tshuaj nquag simvastine hauv ib ntsiav tshuaj yog 10, 20 thiab 40 mg. Lub teb chaws ntawm kev tsim khoom Romania thiab Russia. Lub npe lag luam raws li lub chaw radar yog Simvastol. Txee lub neej yog peb lub xyoos, nws yog hais ntawm lub hlwv.

Sab sij huam

Cov kev mob tshwm sim ntawm cov tshuaj statin chav kawm muaj xws li: mob taub hau, kiv taub hau, pw tsaug zog, mob plab hnyuv plab, mob plab epigastric.

Muaj qee kis, kev thim rov qab ntawm pancreatitis, ua rau lub siab ua haujlwm tsis zoo yuav tshwm sim. Qee zaum muaj kev fab tshuaj rau cov tshuaj ib leeg ntawm cov tshuaj, nrog los ntawm liab thiab khaus.

Tsawg dua, simvastol tuaj yeem ua rau cov metabolism, hloov pauv hauv saj, lub qhov ncauj qhuav, myopathy, exacerbation ntawm mob caj dab, thiab txo qis hauv cov leeg.

Tsuas tshuaj thiab tswj hwm

Kev noj tshuaj ntawm simvastol yog 5-20 mg. Yog tias tsim nyog, hais txog cov lus pom zoo ntawm tus kws kho mob mus kawm, qhov kev cia siab tuaj yeem raug nce nrog lub sijhawm kho ntawm plaub lub lis piam.

Tshuaj ntsiav feem ntau noj ib hnub ib zaug, nrog noj hmo thaum yav tsaus ntuj. Cov ntsiav tshuaj yuav tsum nqos tag nrho yam tsis ntxo. Haus dej kom ntau. Kev kho mob siab tshaj plaws yog 40 mg ib hnub twg.

Rau cov neeg mob uas tau noj tshuaj tiv thaiv kab mob, nws raug nquahu kom noj cov tshuaj nyob rau hauv thawj zaug ntawm 5 mg, nrog rau kev noj tshuaj ntau zaus ib hnub ib zaug. Ua li no, koj tuaj yeem faib cov ntsiav tshuaj nrog kev noj tshuaj ntawm 10 mg ua ob ntu. Qhov siab tshaj plaws rau cov neeg mob no tsis ntau tshaj 5 mg rau ib hnub. Thaum raug mob raum tsis ua haujlwm, cov tshuaj txheem yog 5-10 mg ib hnub. Nrog rau kev siv ua ke ntawm simvastol nrog verapamil thiab amiodarone, cov koob tshuaj yuav tsum tsis pub tshaj 20 mg.

Lub sijhawm kho nrog tshuaj yog txiav txim los ntawm tus kws kho mob. Qhov nruab nrab, txoj kev kho kom zoo yog tsawg kawg ib hlis, qee zaum ntev dua. Cov ntsiav tshuaj yuav tsum noj kom tsis tu ncua thiab siv tshuaj thiab tsis tu ncua.

Thaum noj cov tshuaj, saib xyuas qib theem ntawm cov roj (cholesterol) hauv cov ntshav, nrog rau ib qho kev ntsuas cov kev ntsuas ua rau daim siab. Thaum qhov xav tau txoj kev kho kom tiav yog ua tiav, txoj kev muab tshuaj tuaj yeem raug txo kom tsawg.

Cov khoom ntawm Simvastol

Yog tias tus neeg mob muaj kev tsis haum rau ib leeg rau Simvastol, tus kws kho mob tuaj yeem xaiv cov kev hloov sib luag rau ntawm qhov muaj txiaj ntsig tseem ceeb - simvastatin. Ntawm cov ntsiab analogues tuaj yeem hu ua tshuaj Ariescorp, Vasilil, Zokor.

Nws yog qhov nyuaj rau kev txiav txim siab tias qhov tshuaj twg zoo dua. Lawv qhov sib txawv tseem ceeb hauv cov npe lag luam thiab cov khoom sib xyaw ntawm cov khoom siv ntxiv. Ntxiv rau, qee qhov analogues yuav pheej yig dua.

Tsuas yog tus kws kho mob uas tuaj koom thiaj xaiv tau cov tshuaj zoo uas haum rau koj.

Kev Siv Tshuaj Xyuas

Feem ntau cov kws kho mob nco tau qhov kev ua haujlwm zoo ntawm Simvastol. Txoj kev pheej hmoo ntawm cov kev mob tshwm sim thaum soj ntsuam qhov tshuaj thiab cov lus pom zoo kom tsawg. Cov neeg mob uas tau txais kev kho mob rau cov tshuaj no nco nws txoj kev ua siab zoo, tus nqi pheej yig, nrog rau kev muaj txiaj ntsig zoo ntawm nws cov kev ua. Thawj qhov tshwm sim ntawm cov tshuaj tuaj yeem raug ntsuas tom qab ob rau peb lub lis piam ntawm kev tswj hwm.

Ntawm cov chaw kho mob muaj npe nrov thiab cov portals, muaj qhov ntsuas tsis zoo txog Simvastol. Tab sis koj tuaj yeem nyeem tshuaj xyuas txog cov tshuaj Simvastatin, cov hauv kev ua haujlwm hauv cov nyiaj no yog qhov qub.

Cov ntaub ntawv siv tshuaj dav dav

Simvastol belongs rau cov pab pawg tshuaj - statins, HMG inhibitors ntawm CoA reductase. Cov kab mob zoo li no muaj cov khoom lipid-txo qis. Lub npe txawv teb chaws tsis yog cov tswv ntawm Simavstol yog simvastatin. Cov tshuaj no yog tsim los ntawm lub tuam txhab tshuaj ua lag luam Gideon Richter hauv Romania.

Ib yam tshuaj yog siv los txo cov kev txaus siab ntawm cov phom sij uas tsis muaj roj ntau, tag nrho cov roj (cholesterol) thiab triglycerides. Feem ntau cov feem ntau nws siv nyob rau hauv kev kho mob thiab lub plawv mob txo qis kev pheej hmoo ntawm kev tsim cov kab mob concomitant thiab cov teeb meem.

Tso tawm daim ntawv, nqi

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj muaj zog me uas muaj cov ntxhiab tsw pinkish. Ntim lawv rau hauv hnab yas tawg blooj ntawm 14 daim.

Ua raws li cov ntsiab lus ntawm cov tshuaj nquag hauv ib ntsiav tshuaj ntawm Simvastol (10, 20 lossis 40 mg), tus nqi ntawm cov tshuaj tau txiav txim siab.Tus nqi nruab nrab hauv cov khw muag tshuaj ntawm cov nroog loj hauv tebchaws Russia:

Cov nqi pheej yig yog muab los ntawm cov khw muag tshuaj online. Lawv kuj tuaj yeem xaj kom xa cov tshuaj mus rau qhov chaw nyob.

Cov tshuaj nquag uas yog ib feem ntawm cov tshuaj thiab txiav txim siab nws cov nyhuv yog simvastatin. Nws raug xa mus rau HMG CoA reductase inhibitors. Ib ntsiav tshuaj yuav muaj 10, 20 lossis 40 mg ntawm qhov khoom tivthaiv no.

Cov tshuaj ntxiv ua ib txoj haujlwm pab. Ntawm lawv - lactose, butylhydroxyanisole, ascorbic thiab citric acid, magnesium stearate, gelatin pob kws hmoov txhuv nplej siab. Lawv tus lej nce ntxiv nyob ntawm qhov nce hauv cov ntsiab lus ntawm simvastatin. Cov qog ua yeeb yaj kiab muaj cov xim ua kom daj (daj, liab thiab dub hlau oxide), macrogol, hypromellose, titanium dioxide thiab lwm yam tshuaj.

Kev taw qhia thiab contraindications

Muaj qhov qhia tshwj xeeb rau kev noj tshuaj. Ntawm lawv yog:

1. Hypercholesterolemia ntawm lub hauv paus pib. Cov neeg mob thiaj paub hais tias yog mob hlab ntshav atherosclerosis raug kev txom nyem los ntawm nws. Tib lub sijhawm, cov neeg mob muaj qhov pheej hmoo loj ntawm lub plawv loj.
2. Ua ke hypercholesterolemia.
3. Hypertriglyceridemia.

Yog hais tias muaj cov kev tawm tshiab, cov tshuaj tsuas yog yog tias lwm txoj hauv kev ntawm kev kho tsis tau pab - kev noj zaub mov tshwj xeeb uas pab txo qis lipid, thiab kev teeb tsa ua kom yuag.

Kuj, ntau yam kab mob plawv (cov piv txwv, mob ischemia) yog cov sib txawv ntawm cov cim qhia. Cov tshuaj yuav tau muab rau:

• tiv thaiv tau txoj kev loj hlob ntawm kev mob plawv,
• txo qhov kev pheej hmoo ntawm tus neeg mob tuag,
• txo kev pheej hmoo ntawm mob hlab ntsha tawg lossis ischemic tawm tsam,
• txo txoj kev pheej hmoo ntawm myocardial perfusion rov qab ua tus txheej txheem (rov qab kho dua tshiab),
• qeeb qeeb ntawm qhov muaj mob ntawm atherosclerotic txhab ntawm cov hlab ntshav hlab ntsha.

Cov tshuaj muaj nws cov contraindications thiab kev txwv. Nws yuav tsum tsis ua nyob rau hauv tej yam mob no:

• tus kheej tsis kam txais rau ib lossis ntau ntawm cov feem uas ua rau cov tshuaj,
• hypersensitivity rau statins,
• pob txha leeg mob pathology (myopathy),
• mob rau daim siab hnyav
• nce kev ua si ntawm daim siab enzymes ntawm qhov tsis paub keeb kwm.

Nws tseem yuav tsum tau nyob rau hauv lub hlwb tias cov tshuaj tsis siv los kho cov pawg ntawm cov neeg:

1. Cov menyuam yaus thiab tub ntxhais hluas uas muaj hnub nyoog yau dua. Tsis muaj kev tshawb nrhiav tau coj los ntawm pawg no, yog li nws tseem tsis tau paub tias kev siv tshuaj yeeb yuav zoo li cas.
2. Cev xeeb tub Yog tias cov poj niam ntawm lub hnub nyoog yug menyuam siv Simvastol, ces yuav tsum siv cov kev tswj kom tsis txhob muaj menyuam yaus kom tsis txhob muaj menyuam yaus ntau ntxiv. Thaum cev xeeb tub, cov tshuaj yuav tsum tau muab tshem tawm tam sim ntawd.
3. Saib xyuas niam cov txiv. Cov tshuaj nquag tuaj yeem nkag mus rau hauv niam mis thiab ua rau muaj kev phom sij rau tus menyuam. Yog li ntawd, yog tias nws yuav tsum tau simvastatin, kev pub mis niam kom tsis ua haujlwm.

Muaj qee cov kev txwv hauv qab uas cov tshuaj yog siv nrog qhov yuav tsum tau ceev faj. Ntawm lawv yog:

• ntshav siab
• ntau yam kev raug mob thiab kev khiav haujlwm,
• haus dej caw
• ua txhaum ntawm cov leeg nqaij, mob ib ce ntawm tsis paub tus mob etiology,
• kev ntxhov siab nyob rau hauv daim siab,
• ntxhov siab ntawm cov khoom hluav taws xob,
• cov kab mob metabolic thiab endocrine,
• cov kab mob sib kis hauv cov theem mob nyhav,
• kev hloov khoom nruab nrog hauv nruab nrog cev, tom qab kev tswj hwm ntawm cov tshuaj txhaj tiv thaiv kab mob,

Cov tshuaj muaj contraindications, uas yuav tsum tau txiav txim siab ua ntej nws teem. Hauv qee qhov xwm txheej, nws tau coj nrog ceev faj.

Cov lus qhia rau kev siv

Cov lus qhia rau kev siv tshuaj qhia pom cov ntsiab lus zoo li no:

1. Cov khoom yuav tsum noj qhov ncauj ib hnub ib zaug ua ntej lossis tom qab noj mov (tsis yog noj mov!). Cov ntsiav tshuaj yuav tsum tau nqos tag nrho nrog dej.
2. Ua ntej siv, tus neeg mob tau noj tshuaj tshwj xeeb, uas txwv kev siv cov rog kom tsis zoo thiab pab tshem lawv tawm ntawm lub cev. Nws yuav tsum raug kuaj thoob plaws hauv chav kho mob.
3. Nws yog ib qho tseem ceeb kom ua raws li kev noj ntau uas koj tus kws kho mob pom zoo. Nws tuaj yeem sib txawv ntawm 10 txog 80 mg ntawm simvastatin ib hnub. Qhov siab tshaj koob (80 mg) txwv tsis pub tshaj.

Nrog hypercholesterolemia, tus neeg mob raug xaj 10 mg ntawm cov tshuaj los pib nrog. Ntxiv mus, qhov muab tshuaj yuav tau nce. Koob tshuaj hloov tau yog ua tau tom qab ib hlis ntawm kev siv ib txwm. Rau feem ntau cov neeg mob, cov koob tshuaj zoo tshaj yog 20 mg.

Nrog cov muaj keeb hypercholesterolemia, ib lub tswv yim muab tshuaj yog tshuaj:

• 40 mg ib hnub ib zaug (yav tsaus ntuj lub sijhawm),
• 80 mg hauv peb koob muab faib.

Tseem Ceeb! Yog tias tus neeg mob lub plawv ischemia lossis muaj qhov pheej hmoo siab ntawm nws tshwm sim, tom qab ntawd tus neeg mob tau xaj 20-40 mg ntawm simvastatin. Nrog rau qhov txo qis hauv lipid tom qab kev ntsuam xyuas, qhov ntau npaum no tuaj yeem raug txo kom tsawg. Cov neeg mob los ntawm cov neeg muaj hnub nyoog qib siab lossis cov neeg muaj mob raum ua kom zoo tsis tas yuav txo tau qhov ntau npaum.

Yog tias tus neeg mob muaj cov mob raum tsis zoo los yog nws noj qee qhov tshuaj tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, nicotinic acid, ces qhov siab tshaj plaws tsis pub tshaj 10 mg ib hnub. Thaum noj Amiodarone los yog Verapamil, tsuas yog 20 mg ntawm simvastatin tso cai. Tag nrho cov tshuaj no, thaum noj Simvastol, ua rau muaj kev pheej hmoo ntawm kev mob myopathy.

Muaj cov tshuaj tsis haum thiab noj tshaj

Cov tshuaj muaj qee qhov tshwm sim. Cov feem ntau tsis muaj xws li:

• mob plab, raws plab, cem quav, pom,
• bouts ntawm xeev siab thiab ntuav,
• teeb meem mob siab
• asthenia
• ua txhaum ntawm saj thiab pom kev pom,
• loog ntawm lub cev
• muaj teeb meem nrog hematopoiesis (thrombocytopenia, ua kom ntshav khov, nce ESR),

Kev noj tshuaj ntau dhau yog qhov tsis zoo, tab sis yog tias koj siv ntau dua ntawm cov tshuaj, cov kev mob tshwm sim tuaj yeem sib zog ntxiv. Hauv qhov no, kev kho cov tsos mob yog qhia. Koj tseem tuaj yeem ua lub plab zom zaub mov, noj sorbents lossis siv cov tshuaj hemodialysis.

Zoo sib xws txhais tau tias

Rau ib qho laj thawj lossis lwm qhov, nws cov analogues yog siv los hloov cov tshuaj Simvastol. Lawv yog cov yam ntxwv (lawv muaj tib lub zog qub) thiab cov neeg sawv cev uas zoo sib xws ntawm kev coj ua ntawm kev coj ua. Cov kws kho mob feem ntau hais txog:

1. Zokor. Cov tshuaj ntsuab uas nrov los ntawm Netherlands. Cov tshuaj phiv yog simvastatin. Tus nqi - los ntawm 160 txog 320 rubles.
2. Simvageksal. Cov yam ntxwv analogue ntawm simvastol. Nws yog tsim los ntawm lub tuam txhab tshuaj German German Salyutas Pharma. Nws yog tso tawm ntawm tus nqi ntawm 280-340 rubles.
3. Vasilip. Qhov zoo lipid-txo cov tshuaj uas muaj simvastatin. Lub teb chaws ntawm keeb kwm - Slovenia. Tus nqi ntawm cov tshuaj yog 250-550 rubles.
4. Simvastatin. Cov tshuaj siv hauv tsev. Nws raug nqi yog los ntawm 52 txog 95 rubles.

Txhawm rau xaiv txoj kev los yog hloov lawv nrog cov zoo ib yam tsuas yog tus kws kho mob koom nrog. Kev noj tshuaj pab tus kheej ua rau muaj kev tsis zoo.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv tshuaj ntawm Simvastol yog cov tshuaj zaj duab xis: puag ncig, biconvex, qhov tseem ceeb ntawm cov ntsiav tshuaj yog dawb nrog cov qauv txheej txheem, lub plhaub yog xim paj yeeb (koob tshuaj 10 mg), daj daj (koob tshuaj 20 mg) lossis xim av (koob 40 mg) xim (14 pcs). sawv hlwv, hauv daim duab tuab ntawm 1 los yog 2 lub hlwv).

1 lub ntim zaj duab xis-txheej muaj:

• cov tshuaj nquag: simvastatin - 10, 20 lossis 40 mg,
• Cov khoom xyaw pabcuam: pregelatinized hmoov txhuv nplej siab, lactose monohydrate, ascorbic acid, microcrystalline cellulose PH101, butyl hydroxyanisole, citric acid monohydrate, magnesium stearate,
• xim yeeb yaj kiab / daj / xim av xim txheej xim: Opadry II 33G24737 (lactose monohydrate, hypromellose, titanium dioxide, glycerol triacetate, macrogol, xim liab hlau zas, xim dub hlau, txhuas hlau ua raws xim indigo carmine zas xim) / Opadry II 39G22514 (trirosetin, , titanium dioxide, macrogol, lactose monohydrate, zas xim daj, liab hlau zas, dub hlau zas) / Opadry II 33G26729 (titanium dioxide, macrogol, hypromellose, daj hlau zas xim, glycerol triacetate, jelly xim thiab liab oxide, lactose monohydrate, hlau oxide dub xim).

Noj ntau dhau

Cov mob ntawm kev noj tshuaj ntau dhau ntawm Simvastol paub rau cov kws tshaj lij (qhov ntau tshaj qhov tau txhaj yog 450 mg) tsis tau nrog kev nthuav qhia ntawm cov tsos mob tshwj xeeb. Raws li kev kho mob, lub plab zom mov thiab cov pa hluav taws qhib kom ua haujlwm raug pom zoo. Txoj kev kho mob kuj tseem raug tswj hwm thiab qib qib Kib thiab lub siab thiab lub raum thiab lub siab ua haujlwm raug saib xyuas tas li.

Yog hais tias tus neeg mob tau tsim myopathy nrog rhabdomyolysis thiab mob raum tsis zoo (mob nyhav tab sis tsis tshua muaj kev cuam tshuam), nws yog ib qho tsim nyog yuav tsum thim cov tshuaj thiab qhia sodium bicarbonate thiab diuretic rau tus neeg mob los ntawm kev tso ntshav infusion. Yog tias tsim nyog, kev kho mob hemodialysis tau ua tiav.

Rhabdomyolysis tuaj yeem ua rau hyperkalemia, uas tshem tawm los ntawm kev siv cov pa roj carbon monoxide ion pauv, kev tswj hwm cov calcium gluconate lossis calcium chloride, qabzib infusion nrog ntxiv ntawm cov tshuaj insulin, lossis tshwj xeeb tshaj yog mob hnyav los ntawm hemodialysis.

Cov lus qhia tshwj xeeb

Raws li cov lus qhia, Simvastol yuav tsum tsis txhob raug rau cov neeg mob uas muaj kev pheej hmoo ntawm rhabdomyolysis thiab lub raum tsis ua haujlwm. Cov kev pheej hmoo txaus ntshai rau cov kab mob no suav nrog kev mob hnyav, mob ntshav qis, npaj tswv yim hlais tawm ntau, raug mob, thiab cov teeb meem loj hauv lub cev.

Kev siv cov tshuaj tsis qhia rau hom I, IV thiab V hypertriglyceridemia.

Kev kho mob Simvastol yuav tsum nrog kev tshuaj xyuas txog lub siab ua haujlwm. Kev tshawb fawb ntawm kev ua si ntawm daim siab enzymes yog nqa tawm ua ntej pib kev siv tshuaj thiab ua ntu zus thaum kho: 2 zaug txhua 6 lub lis piam, tom qab ntawd txhua 8 lub lis piam mus txog rau thaum xaus ntawm thawj xyoo, tom qab ntawd ib zaug txhua rau lub hlis. Ib qho kev ntsuam xyuas los txiav txim siab lub siab ua haujlwm yuav tsum tau ua rau ntawm txhua qhov kev nce ntxiv, thiab nrog rau kev noj ib hnub 80 mg rau txhua 12 asthiv. Kev nce qib hauv theem ntawm lub siab enzymes yog ua tau thaum pib ntawm txoj kev kho. Nrog kev ua transaminase ntau dua 3 zaug ntawm thawj theem thiab tswj hwm qhov nce ntxiv, cov ntsiav tshuaj yuav tsum txuas mus ntxiv.

Cov neeg mob hypothyroidism thiab / lossis mob raum (suav nrog nephrotic syndrome) uas muaj cov roj (cholesterol) siab yog qhov pom zoo uantej los kho tus kabmob qis.

Ntxiv nrog rau kev kho mob monotherapy, kev siv cov tshuaj muaj qhia nyob rau hauv ua ke nrog sequestrants ntawm bile acids.

Nws raug nquahu kom tsis txhob siv lub txiaj ntsig loj ib zaug (ntau dua 250 ml) ntawm cov kua txiv kab ntxwv qaub, vim nws muaj peev xwm nce qhov hnyav ntawm kev phiv los ntawm simvastatin.

Tawm tsam keeb kwm ntawm kev siv Simvastol, kev txhim kho ntawm myopathy, rhabdomyolysis thiab lub raum tsis ua haujlwm yog qhov ua tau. Cov tsos mob ntawm cov kab mob no suav nrog qhov pom ntawm cov nqaij pob txha, qhia qhov mob tsis meej, leeg nkees lossis cov leeg tsis muaj zog, nrog los ntawm kev ua kom tsis txhob ua npaws lossis kub ib ce. Txoj kev pheej hmoo ntawm kev tsim myopathy nce nrog tib lub sijhawm siv cov fibrates (fenofibrate, gemfibrozil), nefazodone, cyclosporine, macrolides (clarithromycin, erythromycin), HIV protease inhibitors (ritonavir), cov tshuaj tiv thaiv kab mob ntawm azole pawg (itraconazole, ketocon). Ntxiv rau, qhov ntxim nyiam ntawm kev txhim kho myopathy zoo dua nyob rau hauv cov neeg mob uas mob raum tsis zoo. Thaum sau daim ntawv yuav tshuaj, tus kws kho mob yuav tsum ceeb toom rau tus neeg mob txog qhov muaj peev xwm yuav muaj tus kabmob no, nws cov tsos mob thiab xav tau sai hu rau tus kws khomob tshwj xeeb yog tias lawv txhim kho

Hauv cov neeg mob uas xav tias yog tus mob myopathy, tshem tawm ntawm Simvastol yog qhov yuav tsum tau ua.

Cov neeg mob hnub nyoog yug menyuam yuav tsum siv txoj kev tiv thaiv kom tsis pub dhau lub sijhawm noj tshuaj. Yog tias cev xeeb tub tau tshwm sim thaum kho, cov tshuaj tsis ua haujlwm lawm, thiab tus pojniam yuav tsum ceeb toom tias muaj kev pheej hmoo rau tus menyuam hauv plab.

Kev tshem tawm ntawm cov tshuaj tiv thaiv hypolipidemic thaum cev xeeb tub tsis cuam tshuam qhov tshwm sim ntawm kev kho lub sijhawm ntev ntawm thawj hypercholesterolemia.

Nrog cov tsos ntawm myalgia, myasthenia gravis thiab / lossis cim tau nce hauv CPK cov haujlwm, kev siv Simvastol yuav tsum tsis ua mus ntxiv.

Yog tias koj ua yuam kev siv koob tshuaj ntxiv, nws yuav tsum ua kom sai li sai tau, nco ntsoov tias qhov no tsis txhais tau tias koj noj ob koob tib lub sijhawm.

Hauv kev mob raum tsis zoo, kev kho yuav tsum tau ua los ntawm kev saib xyuas lub raum ua haujlwm.

Tus neeg mob yuav tsum soj ntsuam kev noj ntshav hypocholesterol ua ntej pib siv tshuaj thiab thaum tag nrho lub sijhawm noj Simvastol.

Cov nyhuv ntawm cov tshuaj rau tus neeg mob lub peev xwm tsav tsheb thiab cov tswv yim tsis tau tsim.

Yeeb tshuaj sib cuam tshuam

Txoj kev pheej hmoo ntawm myopathy raug cuam tshuam los ntawm kev siv tib lub sijhawm cytostatics, fibrates, immunosuppressants, nefazodone, erythromycin, clarithromycin, azole antifungals, HIV protease inhibitors, muaj ntau cov nicotinic acid, telithromycin, ntxiv rau, ntawm simvastatin ntau dua - cyclosporine. amiodarone, verapamil, diltiazem.

Lub bioavailability ntawm simvastatin raug txo qis los ntawm colestipol thiab colestyramine, yog li ntawd, nrog kev kho kom sib xyaw kom ua tiav cov txiaj ntsig ntxiv, simvastol yuav tsum noj tsis pub dhau 4 teev tom qab cov nyiaj tau hais tseg.

Cov tshuaj ua rau nce theem ntawm cov digoxin hauv ntshav ntshav.

Simvastatin nce cov nyhuv ntawm qhov ncauj anticoagulants (suav nrog fenprocoumone, warfarin) thiab kev pheej hmoo los ntshav, yog li ntawd, ua ntej pib kev kho mob ua ke, nws yog qhov tsim nyog los txiav txim qhov sib xyaw ntawm cov neeg mob thiab ua tib zoo saib lawv nyob rau lub sijhawm pib kho. Tom qab ncav lub sijhawm ruaj khov ntawm cov sij hawm prothrombin, lawv hloov mus rau txoj kev kho mob txheem nrog cov tshuaj anticoagulants. Yog tias koj hloov koob tshuaj lossis tso tseg tsis noj, koj yuav tsum siv cov tshuaj tswj sijhawm prothrombin saum toj no.

Nrog rau kev kho mob monotherapy, simvastol tsis cuam tshuam rau qhov kuaj pom ntawm lub sijhawm prothrombin thiab muaj kev pheej hmoo los ntshav.

Cov kua txiv kab ntxwv ua rau muaj kev cuam tshuam ntau ntxiv tiv thaiv HMG-CoA reductase hauv cov ntshav ntshav.

Cov cim ntawm Simvastol yog: Aterostat, Holvasim, Vasilip, Simgal, Avestatin, Simplakor, Vero-Simvastatin, Simvor, Actalipid, Sinkard, Zokor forte, Simlo, Zovatin, Simvakard, Levomir, Simvastatin, Arieskor, Simvakor, Zorstor.

Tus nqi ntawm Simvastol hauv cov chaw muag tshuaj

Tus kwv yees tus nqi rau Simvastol 10 mg yog 180-216 rubles. (rau ib pob li 28 ntsiav tshuaj). Tus nqi ntawm cov ntsiav tshuaj nrog qhov ntau npaum ntawm 20 mg thaj tsam 280–320 rubles. (28 ntsiav tshuaj hauv pob).

Kev Kawm Ntawv: Thawj Moscow State Medical University muaj npe tom qab I.M. Sechenov, tshwj xeeb "Tshuaj General".

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Thaum lub sijhawm ua haujlwm, peb lub hlwb siv ntau npaum li cas ntawm lub zog sib npaug rau 10-watt lub teeb lub teeb. Yog li cov duab ntawm lub teeb txawb saum koj lub taub hau thaum lub sijhawm pom ntawm qhov kev xav zoo nkauj tsis yog deb ntawm qhov tseeb.

Yog tias koj lub siab ua haujlwm, kev tuag yuav tshwm sim hauv ib hnub.

Tus neeg muaj kev kawm paub tsis yooj yim rau cov kab mob hlwb. Cov kev txawj ntse ua haujlwm koom nrog kev tsim cov ntaub so ntswg ntxiv los txhawb rau cov neeg mob.

Txhua tus neeg muaj tsis tsuas yog nyias tus ntiv tes, tab sis kuj hais lus.

Muaj 74 xyoo nyob hauv tebchaws Australian yawg James Harrison tau los ua neeg muab ntshav li 1,000 zaus. Nws muaj ib hom ntshav uas tsis tshua muaj, cov tshuaj tiv thaiv uas pab cov menyuam mos liab uas muaj ntshav tsawg txaus kom ciaj sia taus. Yog li, Australian thiaj cawm tau ntau txog ob lab tus menyuam.

Raws li kev tshawb fawb los ntawm WHO, kev sib tham ib nrab hnub nyob rau ntawm lub xov tooj ntawm tes tau qhov feem ntau ntawm kev txhim kho lub hlwb lub hlwb los ntawm 40%.

Qhov ua kom pom kev vibrator ua ntej nyob rau xyoo 19th. Nws ua haujlwm ntawm lub tshuab tso hluav taws xob thiab nws tau npaj kho qhov mob poj niam.

Tus neeg noj tshuaj tiv thaiv kab mob feem ntau yuav rov qab muaj kev nyuaj siab. Yog tias ib tug neeg mob nrog kev nyuaj siab ntawm nws tus kheej, nws muaj txhua lub sijhawm tsis nco qab txog lub xeev no tas mus li.

Cov tshuaj hnoos "Terpincode" yog ib tus thawj coj hauv kev muag, tsis muaj vim tias nws muaj tshuaj.

Yog tias koj poob los ntawm tus nees luav, koj nyiam yob koj lub caj dab ntau dua li yog koj ntog los ntawm nees. Tsuas tsis sim rau refute nqe lus no.

Ntxiv rau tib neeg, tsuas yog ib tus tsiaj muaj sia nyob ntawm ntiaj chaw ntiaj teb - dev, raug kev txom nyem los ntawm prostatitis. Cov no yog peb cov phooj ywg ncaj ncees tshaj plaws.

Ntau cov tshuaj tau xub pib ua lag luam li tshuaj. Piv txwv li yeeb dawb, tau pib ua lag luam ua tshuaj hnoos. Thiab cocaine tau pom zoo los ntawm cov kws kho mob ua tshuaj loog thiab yog lub zog ntawm kev ua kom lub siab ntev.

Caries yog hom kis tau yooj yim tshaj plaws hauv ntiaj teb uas txawm tias tus mob npaws tsis tuaj yeem sib tw nrog.

Cov tshuaj muaj npe zoo "Viagra" tau tsim thaum chiv thawj los kho kev mob ntshav siab los ntawm arterial tawg.

Plaub qho ntawm chocolate tsaus muaj txog ob puas calories. Yog li yog tias koj tsis xav tau zoo dua, nws zoo dua tsis txhob noj ntau tshaj li ob lobules ib hnub.

Txhua tus tuaj yeem ntsib cov xwm txheej uas nws plam hniav. Nov yog ib qho txheej txheem niaj hnub ua los ntawm kws kho hniav, los yog ua rau muaj kev raug mob. Hauv txhua thiab.

Muaj dab tsi hauv cov chaw muag tshuaj?

Cov lus qhia "Simvastola" muaj cov lus piav qhia tseeb ntawm qhov sau ntawm lub ntim. Yog tias muaj qhov tsis sib xws ntawm cov ntaub ntawv hauv cov ntaub ntawv xa nrog thiab cov ntawv tam sim no, koj yuav tsum hu rau lub tsev muag tshuaj kom hloov cov ntim. Feem ntau, cov tshuaj muaj xim nyob hauv liab dawb (10 mg) lossis daj (20 mg). Txhua qhov ua piv txwv yog xim, ua raws tus qauv ntawm lub voj voog. Cov khoom yog homogeneous, cov npoo yog qhov ruaj khov. Yog tias koj txiav cov tshuaj, koj tuaj yeem pom ob txheej: qhov tseem ceeb yog dawb, ntug yog nyias, paj yeeb lossis daj (nyob ntawm seb qhov ntau npaum li cas ntawm cov khoom siv nquag).

Cov lus qhia ntawm "Simvastol" hais txog tias lub npe belongs rau cov pab pawg ntawm lipid-txo qis. Cov cuab yeej yog tsim synthetically, yog ib yam khoom fermentation ntawm Aspergillus terreus.

Yuav siv kom raug li cas?

Cov chaw tsim khoom lag luam kos kom pom tseeb tias Simvastol (kev tshuaj xyuas tau paub meej qhov tseeb no) thaum pib siv yuav ua rau muaj kev nce siab ntxiv ntawm daim siab enzymes. Maj mam, qhov xwm txheej tau hloov kho nws tus kheej, tsis muaj kev ntsuas tshwj xeeb, tsis tas yuav tshem tawm cov tshuaj no. Feem ntau, kev haus tshuaj yog qhov zoo, thiab kev cuam tshuam los cuam tshuam tsawg, txawm tias muaj.

Xws li thaum pib ntawm kev siv "Simvastol", thiab tom qab ntawd nws yog ib qho tseem ceeb rau kev soj ntsuam tas li kom saib xyuas qhov zoo ntawm lub siab. Thawj peb lub hlis ntawm kev kho mob, kev txheeb xyuas qhov tseeb ntawm cov kab mob hauv lub cev yog nqa tawm txhua 6 lub lis piam, tom qab ntawd lub sijhawm nce ntxiv los ntawm lwm ob lub lis piam, khaws qhov no rau ib xyoos. Nrog kev muaj peev xwm tiv taus ib txwm thiab txuas ntxiv ntawm kev siv cov tshuaj, lub siab lub siab yuav tsum kuaj xyuas ib xyoos ib zaug.

Txoj haujlwm hloov

Raws li qhia hauv kev txheeb xyuas, "Simvastol" yuav cuam tshuam rau daim siab, yog tias tus kws kho mob pom zoo hloov kho ntau npaum li cas ntawm cov tshuaj. Yog tias tus kws kho mob tau sau cov tshuaj loj, koj yuav tsum tau mus rau tom tsev kho mob kom tsis tu ncua los kuaj xyuas lub siab ua haujlwm. Yog tias qhov koob tau 80 mg, nws raug nquahu kom coj mus ntsuas nrog lub sijhawm peb-hlis ib hlis. Yog tias cov kev tshawb fawb nthuav tawm cov kev ua ub no tsis siab dua cov cai ntawm hepatic transaminases, txoj kev kho kom zoo tiav. Qhov ntsuas tau rau qhov no yuav yog peb lub sij hawm qhov txiaj ntsig tshaj qhov ntsuas cov cim qhia hauv kev kawm txog kev noj qab haus huv ntawm lub cev. Txawm li cas los xij, raws li tau sau tseg los ntawm cov neeg mob kho nrog Simvastol, qhov yuav tsum tau thim tawm yog qhov tsawg. Txawm hais tias muaj qhov nce ntxiv ntawm cov tshuaj txhua txhua hnub, cov tshuaj noj tau zoo los ntawm lub cev, tsis ua rau muaj kev tsis zoo.

Yuav tsum muaj kev saib xyuas tshwj xeeb

Simvastol ntsiav tshuaj (analogues uas zwm rau qeb ntawm HMG-CoA reductase, ib yam nkaus thiab) tsis yog siv rau yog tias qhov ntxim nyiam ntawm rhabdomyolysis thiab lub raum tsis ua haujlwm tau nce. Feem ntau cov xwm txheej zoo li no nrog cov mob hnyav, hypotension, thiab raug mob. Simvastol yuav tsum tsis txhob siv yog tias cov teeb meem loj hauv cov zaub mov tau pom lawm, kev ua haujlwm loj yog cia siab nyob rau yav tom ntej.

Hauv qhov ntsuas rau kev siv ntawm "Simvastol" muaj qhov hais txog ntawm thawj qib hypercholesterolemia. Yog tias txoj kev kho siv cov tshuaj piav qhia tau ntev txaus, kev tshem tawm tshuaj vim tias cev xeeb tub tsis ua rau muaj kev cuam tshuam rau tus neeg mob tus mob.

"Txaus nyiam" txoj hauj lwm

Kev tshuaj xyuas txog kev siv "Simvastol" muaj cov ntaub ntawv qhia txog kev pom zoo sai sai ntawm cov kws kho mob kom tsis txhob noj cov tshuaj thaum cev xeeb tub. Lub tebchaw thaiv qhov kev ua haujlwm ntawm HMG-CoA reductase ua rau kev tsim cov cholesterol nyob rau hauv cov ntaub so ntswg ntawm lub cev, tab sis cov tshuaj sib xyaw no, nrog rau lwm cov tshuaj uas tsim hauv cov txheej txheem hluavtaws, tsim nyog rau kev txhim kho ntawm lub cev. Kev siv cov "Simvastol" tuaj yeem ua rau tsis raug ntawm cov khoom noj ntawm lub cell, steroids. Yog tias Simvastol raug sau tseg rau tus poj niam lub sijhawm thaum cev xeeb tub tuaj yeem ua tiav, kev tiv thaiv yuav tsum tau ua mus txog thaum ua tiav kev kho kom zoo. Yog tias pom muaj xeeb tub thaum lub sijhawm kho, Simvastol raug tso tseg, thiab tus neeg mob tau qhia txog txhua yam kev phom sij cuam tshuam nrog rau cov xwm txheej hauv cev xeeb tub.

Cov lus qhia rau kev siv "Simvastol" muaj cov lus pom zoo kom thim tsis tau kev kho mob nrog cov cuab yeej no yog tias tus neeg mob hnub nyoog deev tsis siv tshuaj tiv thaiv.

Cov yam ntxwv tseem ceeb: siv kom zoo

Cov lus qhia rau kev siv "Simvastol" muaj qhov taw qhia ntawm kev kho mob tshwj xeeb ntawm qee cov neeg mob. Yog tias kuaj tau hypothyroidism, nephrotic syndrome tau kuaj pom, lwm cov kab mob hauv lub raum raug tshawb pom, Simvastol yuav tsum tsis txhob siv tshuaj sai, sai li sai tau qhov kev kuaj pom tias nce cov roj cholesterol hauv cov ntshav. Qhov zoo tshaj plaws mus kom ze yog lub luag hauj lwm kev kho mob ntawm tus kab mob uas ua rau muaj qhov tshwm sim, thiab tsuas yog thaum nws tau tshem tawm, koj tuaj yeem hloov mus rau Simvastol txhawm rau kho tus neeg mob.

Cov lus qhia tshwj xeeb txog kev siv rau "Simvastol" muaj hais txog cov neeg kev txom nyem los ntawm kev quav cawv. Nws yog ib qho tseem ceeb uas ib txwm kuaj xyuas cov cim tseem ceeb ntawm lub cev kom tiv thaiv tau cov lus teb tsis zoo los ntawm cov kab ke sab hauv. Kev kho mob tshwj xeeb yog yuav tsum tau ua los ntawm ntau daim siab mob raug mob los ntawm tus neeg mob, hais hauv keeb kwm kev kho mob. Hauv ib qho ntawm cov kev xaiv, kev kho yog tas nrog cov khoom noj tshwj xeeb xaiv nrog cov roj (cholesterol) tsawg kawg nkaus.

Kev raug mob thiab cov cai ntawm kev txais neeg kawm

Cov lus qhia rau kev siv "Simvastol" tsis pom zoo kom noj kua txiv qaub thaum lub sijhawm kho nrog cov tshuaj, vim qhov no tuaj yeem ua rau muaj kev cuam tshuam ntau yam tshwm sim. Cov neeg raug kev txom nyem los ntawm myalgia, myasthenia kuj tsim nyog tshwj xeeb. Feem ntau, kev siv Simvastol raug txwv nyob rau hauv cov xwm txheej zoo li no. Kev kho nrog cov tshuaj yuav tsum tsis ua ntxiv yog tias txo lub siab rau CPK pom. Tsis txhob siv cov khoom yog tias tus neeg mob tau qhia tawm hypertriglyceridemia ntawm thawj, plaub, hom tsib.

Zoo li analogues, hloov pauv rau tshuaj, Simvastol tuaj yeem ua rau muaj kev tsis haum rau lub cev. Muaj qhov ntxim nyiam ntawm kev tsim myopathy, mob rhabdomyolysis, mob raum tsis ua haujlwm. Qhov ntxim nyiam xws li kev nthuav dav ntawm cov xwm txheej muaj ntau dua yog tias tus neeg mob siv lub npe piav qhia ib txhij nrog cov fibrates, cov tshuaj tua kab mob los ntawm cov pab pawg ntawm macrolides, cyclosporins, thiab nefazodone. Qee qhov kev phom sij muaj feem cuam tshuam nrog kev siv "Simvastol" thiab azole antifungal cov neeg sawv cev, HIV tiv thaiv kom tsis txhob muaj kab mob. Myopathy ntxim yuav cuam tshuam thaum noj Simvastol hauv cov neeg mob raum tsis ua haujlwm zoo.

Paub thiab nkag siab

Ntawm qhov kev pom zoo kom noj, raws li cov lus qhia "Simvastol", analogues uas koom nrog tib hom tshuaj, nrog rau cov xwm txheej uas yuav tsum tau siv ntau ntxiv, hauv kws kho mob thaj chaw muaj lub luag haujlwm yog ceeb toom tus neeg mob txog qhov yuav ua rau muaj myopathy. Tus kws tshaj lij tau hais txog qhov tseeb tias qhov tshwm sim tsis hnov ​​mob ua haujlwm tau tshwm sim tsis ntev tom qab pib kev pib lossis nce ntxiv rau qhov ntau npaum li cas, nrog rau kev hnov ​​mob plab, mob leeg tsis muaj zog, lub cev tsis muaj zog, yog lub sijhawm uas nrhiav kev pab sai sai. Nws tseem ceeb heev uas yuav tsum tau mus ntsib tsev kho mob yog tias tus mob febrile lossis muaj kev txhawj xeeb txog kev ua tsis zoo. Hauv cov xwm txheej zoo li no, txais tos ntawm cov tshuaj yog tam sim ntawd nres. Kev tshem tawm tau tshwm sim sib npaug nrog kuaj mob myopathy, thiab nyob rau hauv qhov kev xav ntawm qhov xwm txheej no.

Thaum siv Simvastol, hloov chaw rau cov tshuaj no xaiv los ntawm tus kws kho mob, koj yuav tsum tau mus xyuas lub tsev kho mob tsis tu ncua kom kuaj tau KFK. Qhov no pab tiv thaiv myopathy. Nws paub tias cov txheej txheem ntawm kev siv cov tshuaj yuav nrog tus nce hauv CPK hauv ntshav dej. Yog tias mob hauv siab, tus kws kho mob yuav siv lub ntsej muag no. Cov tshuaj kho mob raug muab tso tseg yog tias CPK muaj siab dua tus qauv kaum zaus lossis ntau dua.

Yuav siv li cas?

Raws li tau hais hauv kev txheeb xyuas, cov lus qhia rau kev siv, Simvastol muaj txiaj ntsig zoo li ob qho tshuaj nkaus xwb rau kev kho mob ntawm tus neeg mob thiab ua ib qho ntawm txoj kev kho mob. Cov txiaj ntsig tau zoo yog pom los ntawm kev sib xyaw ntawm Simvastol thiab bile acid sequestrants. Cov neeg tsim khoom lag luam pom zoo tias thaum dhia cov koob tshuaj ntxiv, nqa lub ntim ploj mus kom sai li sai tau, tab sis tsis txhob muab ob npaug tshuaj yog tias hla ntawm pom los ntawm lub sijhawm koj xav tau noj ntu tom ntej. Yog tias kev ua haujlwm ntawm lub raum yog mob hnyav, Simvastol raug xaj tsuas yog yog nws ua tau txuas ntxiv soj ntsuam kev ua haujlwm ntawm lub cev no. Lub sijhawm ntawm kev kho kom haum yog ib txwm txiav txim siab los ntawm tus kws kho mob, tsis muaj cov zaub mov txawv thoob plaws rau qhov no. Tus kws kho mob ntsuas xyuas tus neeg mob qhov mob, kuaj mob, cuam tshuam nrog cov kab mob, lub cev cov lus teb rau kev kho mob, raws nws ua cov kev kawm ntev npaum li cas.

Tam sim no tsis muaj xov xwm hais tias Simvastol tuaj yeem cuam tshuam tsis zoo rau tus neeg mob lub peev xwm. Nws tsis muaj qhov cuam tshuam rau ntawm cov tshuaj tiv thaiv tus nqi. Tsis muaj kev hloov kho lub neej, tsis kam tsav tsheb thauj thaum kho yuav tsum ua.

Cov ntsiab lus kev

Raws li qhia hauv cov lus qhia, "Simvastol" yog ib qho kev tawm tsam tsis muaj tseeb. Ib zaug nyob hauv tib neeg lub cev, cov tshuaj nkag mus rau hauv cov tshuaj tiv thaiv hydrolysis, cov khoom lag luam uas muaj kev ua haujlwm, inhibiting HMG-CoA. Qhov ua tau zoo ntawm kev noj tshuaj yog vim qhov tseeb ntawm kev tiv thaiv kev hloov pauv ntawm HMG-CoA rau mevalonate, thiab cov tshuaj tiv thaiv no yog ib theem thaum ntxov ntawm kev tsim cov roj (cholesterol). "Simvastol" tsis ua rau kom cov tsub zuj zuj ntawm sterols hauv cov ntaub so ntswg hauv lub cev, uas kwv yees los ntawm cov kws tshaj lij yuav yog qhov zoo tshaj plaws - cov tebchaw muaj feem rau cov chav kawm uas muaj tshuaj lom. HMG-CoA hloov pauv mus rau acetyl-CoA, uas yog lub hauv paus koom nrog ntau yam kev cuam tshuam hauv tib neeg lub cev.

Cov kev ntsuam xyuas tshwj xeeb tau pom tias cov khoom sib xyaw ua ke yog adsorbed nrog lub siab ntawm cov txheej txheem ua haujlwm. Cov tshuaj nce mus txog nws qhov siab tshaj plaws nyob rau hauv cov roj ntsha hauv lub sijhawm tsuas yog ib teev thiab ib nrab los ntawm lub sijhawm nws tau noj (qee zaus lub sijhawm luv los txog 150 feeb), qhov ntsuas tau poob qis los ntawm 90% tom qab ib nrab hnub. Txog 95% nkag mus rau hauv cov kab nrig ruaj khov nrog ntshav. Kev tshem tawm ib nrab-lub neej ntawm cov khoom siv tshuaj tiv thaiv metabolic nrog kev ua si yog me ntsis tsawg dua ob teev. Ntau tshaj li ib nrab ntawm cov tebchaw raug tawm hauv cov quav, txog 10-15% - los ntawm ob lub raum, daim ntawv yog qhov tsis ua haujlwm.

Dab tsi yog mus hauv lub cev?

Nrog rau kev siv tshuaj kom tsim nyog raws li cov lus qhia hauv cov ntshav ntshav, cov ntsiab lus ntawm LDL, VLDL, cov roj ntsha triglyceride, thiab cov roj (cholesterol) hauv feem ntau poob qis. Qhov no ua rau cov tshuaj muaj txiaj ntsig hauv cov kab mob sib xyaw, tsis yog tsev neeg, tsev neeg heterozygous, uas yog, cov xwm txheej thaum nws yog qhov tseeb cov kev nce siab ntawm cov cholesterol uas yog qhov tseem ceeb txaus ntshai-qhia tau. HDL nyob rau hauv txoj hlab ntaws nce, thiab qhov sib piv ntawm LDL rau LAPA poob qis. Qhov ntsuas ntawm tag nrho cov roj (cholesterol) thiab HDL tsawg zuj zus lawm. Cov nyhuv ntev kawg tau pom ob lub lis piam tom qab pib kev kho mob, uas feem ntau hais tau ua tiav los ntawm lub lim tiam thib tsib ntawm kev kho mob (qee zaum me ntsis ua ntej lossis tom qab me ntsis). Sij hawm ntawm kev txiav txim - tag nrho kho chav kawm. Thaum kawg ntawm cov tshuaj, cov qib roj cholesterol maj mam rov qab los rau lawv qhov tseem ceeb.

Thaum tsa

Raws li cov hauv qab no los ntawm kev txheeb xyuas, cov lus qhia rau kev siv, "Simvastol" (analogues ib yam nkaus) tau pom zoo rau cov neeg uas tau txheeb xyuas hom thawj hom mob hypercholesterolemia, thaum cov zaub mov noj tsis qhia txog kev txhim kho tseem ceeb, txawm tias kev noj zaub mov hauv cov roj ntshav yog tswj tau kom meej meej. Cov tshuaj tau pom zoo yog tias lwm yam kev ntsuas los txo cov kev xav hauv cov roj (cholesterol) tau sim, tab sis txhua tus ntawm lawv tau qhia txog qhov tsis muaj txiaj ntsig txawm tias nyob hauv qhov kev txo qhov hnyav thiab nce kev siv lub cev. Simvastol tsuas raug sau tseg hauv qhov xwm txheej uas qhov pheej hmoo mob leeg ntshav txha npau yog kwv yees saum qhov nruab nrab. Nws tuaj yeem siv, yog tias hypercholesterolemia tau tsim, qhov nce ntxiv ntawm triglycerides ntawm ib hom sib xyaw. Ib qho xwm txheej zoo sib xws yog qhov tsis muaj peev xwm ntawm kev noj zaub mov, kev siv dag zog, tsis siv tshuaj ntawm lwm txoj kev npaj.

"Simvastol" tau sau ntawv rau mob ischemia ua ib qho kev tiv thaiv kev tiv thaiv kev mob plawv, txo txoj kev pheej hmoo ntawm kev tuag los ntawm ischemia. Kev siv cov tshuaj kom zoo tuaj yeem txo qhov kev pheej hmoo ntawm kev ua haujlwm tsis zoo ntawm lub siab, ntshav khov. Lub cuab tam qhia tau tshwj xeeb cov txiaj ntsig nrog kev pheej hmoo siab ntawm transistor tawm tsam ischemia, mob stroke. Yog tias pom tias muaj kab mob atherosclerosis, kev siv Simvastol pab ua rau qeeb kev txhim kho ntawm tus kabmob thiab txo qhov kev pheej hmoo ntawm revascularization.

Thaum twg nws tsis yooj yim sua?

"Simvastol" tsis yog rau kev kho mob ntawm cov neeg uas nws lub cev muaj qhov rhiab siab ntxiv rau cov khoom ua si nquag, lwm yam tshuaj siv hauv kev tsim cov tshuaj. Ua tiav cov npe ntawm cov khoom siv tau muab rau hauv cov ntaub ntawv xa nrog cov ntaub ntawv uas tau muab nrog hauv pob ntawv ntsiav tshuaj. Koj tsis tuaj yeem siv "Simvastol" yog tias tus neeg mob lub cev tsis zam cov tshuaj statin.Ua ntej sau cov tshuaj, nws yog ib qho tseem ceeb uas kuaj tus neeg mob cov keeb kwm kho mob kom ntxaws.

Simvastol tsis yog tsim rau kev kho mob ntawm cov neeg muaj kev mob siab hauv daim ntawv ntawm exacerbation, zoo li rau kev ua haujlwm ruaj khov ntawm daim siab enzymes dua li ib txwm, yog tias kev coj ua ntawm qhov teeb meem no tsis pom. Koj tuaj yeem siv tsis tau cov tshuaj yog tias porphyria, myopathy tau tsim. Cov tshuaj tsis yog npaj rau kev kho mob rau cov menyuam yaus, tsis muaj xov xwm hais txog kev ua haujlwm ntawm kev kho mob, kev nyab xeeb ntawm Simvastol rau tus neeg mob.

Cwj pwm yog tus yuam sij rau kev nyab xeeb

Simvastol tuaj yeem siv nrog kev saib xyuas zoo los ntawm cov neeg quav rau cov dej cawv. Tsuas yog nyob rau hauv kev saib xyuas tas li ntawm kws kho mob tuaj yeem siv tshuaj yog tias hloov khoom nruab nrog tau hloov chaw tsis ntev los no. Ib qho tshwj xeeb mus kom txog yog yuav tsum tau los ntawm cov neeg noj ib chav tshuaj uas muaj kev tiv thaiv tsis muaj zog tiv thaiv kab mob, vim tias muaj peev xwm ua mob pob txha, mob raum tsis ua haujlwm. Ib qho kev sib raug zoo tshwj xeeb yuav tsum tau ua rau tus neeg uas muaj tus mob ua rau pom tias muaj peev xwm ntxiv lub raum tsis ua haujlwm. Hauv tshwj xeeb, cov no yog cov cuam tshuam hauv kev ua haujlwm ntawm cov endocrine caj pas, cov metabolism, kab mob kis loj hauv cov mob ceev, hypotension.

"Simvastol" yog siv nrog kev ceev faj yog tias tus neeg mob tau teem sijhawm mus phais mob, suav nrog kws kho hniav. Ib qho kev tshwj xeeb tseem ceeb yog tsim nyog yog tias dej-electrolytic sib cais cuam tshuam, raug mob, qhov tsis txaus ntawm cov leeg nqaij pob txha tau raug txheeb xyuas, thiab qhov ua rau tus mob no tsis tuaj yeem txiav txim siab. "Simvastol" yog qhov tso cai, tab sis tsuas yog nyob rau hauv kev saib xyuas ntawm tus kws kho mob, yog tias tus neeg mob muaj mob vwm.

Ntau los sis me me?

Tam sim no, kwv yees li 300 rubles tau raug nug rau hauv ib pob ntawm cov tshuaj hauv cov lus nug hauv cov khw muag tshuaj. Tus nqi tshwj xeeb yog txiav txim siab los ntawm qhov tsuas tshuaj ntawm lub nquag sib txuas hauv tshuaj ntsiav, txoj cai nqe ntawm lub tuam txhab tshuaj. Cov cim qhia ntawm Simvastol nthuav tawm ob qho tib si kim thiab qee tus nqi pheej yig dua. Nyob rau hauv dav dav, lub npe piav qhia nyob muaj pes tsawg tus ntawm cov nyiaj muaj los ntawm nws pawg. Yog tias nws yog qhov yuav tsum tau xaiv los hloov chaw, cov kws kho mob feem ntau xav nqua hu cov npe:

Ntawm cov analogues txhim khu kev qha ntawm Simvastol yog Aterostat, Simvor, thiab Simplacor. Nws yog categorically tsis pom zoo xaiv qhov hloov koj tus kheej, qhov no tuaj yeem ua rau tsis muaj kev kho kom zoo, kev mob tshwm sim, suav nrog myopathy. Kev siv ntawm ib qho tshuaj twg, nws hloov nrog analogues yuav tsum tau koom tes nrog tus kws kho mob koom nrog uas tau teev cov tshuaj.