Atomax (Atomax) - cov lus qhia rau kev siv > Kev khomob thiab kev tiv thaiv

Lub npe thoob ntiaj teb - atomax

Kev Sau ua ke thiab daim ntawv ntawm kev tso tawm

Zaj duab xis-coated ntsiav tshuaj yuav luag dawb, puag ncig, biconvex, nrog ib qho thais ntawm ib sab, me ntsis kev tso cai yog tso cai. 1 ntsiav tshuaj muaj atorvastatin (hauv daim ntawv ntawm atorvastatin calcium trihydrate) 10 mg.

Tshwjxeeb: calcium carbonate - 6 mg, lactose - 52.5 mg, pob kws hmoov nplej pob kws - 25.66 mg, croscarmellose sodium - 5,21 mg, povidone (K-30) - 3.5 mg, magnesium stearate - 2 mg, anhydrous colloidal silicon dioxide - 1.5 mg, crospovidone - 4 mg

Muaj pes tsawg leeg plhaub: primellose 15 CPS - 2.05 mg, purified talc - 0.22 mg, titanium dioxide - 0.36 mg, triacetin - 0.16 mg.

10 Pcs. - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (4) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (5) - pob khoom ntawm cardboard.

Tshwjxeeb: calcium carbonate - 10 mg, lactose - 78.34 mg, hmoov nplej pob kws - 40 mg, croscarmellose sodium - 10.47 mg, povidone (K-30) - 5 mg, magnesium stearate - 4 mg, anhydrous colloidal silicon dioxide - 3 mg, crospovidone - 7 mg

Muaj pes tsawg leeg plhaub: primellose 15 CPS - 3.3 mg, purified talc - 0.36 mg, titanium dioxide - 0.58 mg, triacetin - 0.26 mg.

10 Pcs. - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (4) - pob khoom los ntawm cardboard.
10 Pcs. - hlwv (5) - pob khoom ntawm cardboard.

Cov chaw soj ntsuam thiab chaw muag tshuaj

Cov tshuaj pab pawg kho mob

Tus sawv cev lipid-txo qis yog HMG-CoA reductase inhibitor.

Pharmacological kev txiav txim ntawm Atomax

Hypolipidemic tus neeg sawv cev los ntawm pawg statins. Xaiv cov kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl coenzyme A rau mevalonic acid, ua ntej ntawm sterols, suav nrog cov roj (cholesterol). TG thiab cov roj (cholesterol) hauv lub siab muaj nyob hauv VLDL, nkag rau hauv cov ntshav thiab thauj mus rau cov ntaub so ntswg ib ncig.

LDL yog tsim los ntawm VLDL thaum muaj kev sib cuam tshuam nrog LDL receptors. Nws txo qhov kev haum xeeb ntawm cov roj (cholesterol) thiab lipoproteins nyob rau hauv ntshav vim yog vim li cas los ntawm HMG-CoA reductase, kev sib xyaw ntawm cov roj (cholesterol) nyob rau hauv daim siab thiab nce ntxiv ntawm cov "siab" LDL receptors nyob rau ntawm tes, uas ua rau muaj kev nce siab thiab catabolism ntawm LDL.

Txo qhov tsim ntawm LDL, ua rau muaj suab tshaj tawm thiab pheej ua kom nce ntxiv hauv cov dej num ntawm LDL receptors. Kev txo qis LDL cov ntsiab lus hauv cov neeg mob homozygous tsev neeg hypercholesterolemia, uas feem ntau tsis teb rau kev kho nrog lipid-txo tshuaj.

Txo cov ntsiab lus ntawm cov roj (cholesterol) tag nrho los ntawm 30-46%, LDL - los ntawm 41-61%, apolipoprotein B - los ntawm 34-50% thiab TG - los ntawm 14-33%, ua rau muaj qhov nce ntawm HDL cov cholesterol thiab apolipoprotein A. Dose-dependently txo qhov kev xav ntawm LDL hauv cov neeg mob nrog homozygous cov kab mob siab hypercholesterolemia tiv thaiv kev kho mob nrog lwm cov tshuaj tiv thaiv hypolipidemic.

Tseem ceeb txo txoj kev pheej hmoo ntawm kev tsim ischemic muaj teeb meem (suav nrog kev loj hlob ntawm kev tuag los ntawm myocardial infarction) los ntawm 16%, kev pheej hmoo rov qab pw hauv tsev kho mob rau angina pectoris, nrog cov cim ntawm myocardial ischemia, los ntawm 26%. Nws tsis muaj carcinogenic thiab mutagenic teebmeem. Kev ua rau txoj kev kho tau tiav 2 lub lis piam tom qab pib kho, mus txog qhov siab kawg tom qab 4 lub lis piam thiab kav ntev hauv lub sijhawm kho.

Cov Tshuaj Pharmacokinetics

Kev tshem tawm yog qhov siab. Lub sijhawm mus txog C_max - 1-2 teev, C_max cov tshuaj yeeb dej caw hauv cov ntshav ntshav hauv cov poj niam yog 20% siab dua, AUC qis dua 10%, Cmax hauv cov neeg mob haus cawv yog 16 zaug, AUC yog 11 zaug siab dua li ib txwm. Khoom noj khoom haus me ntsis txo qhov nrawm thiab ncua sijhawm ntawm kev nqus ntawm cov tshuaj (los ntawm 25% thiab 9%, feem), tab sis qhov txo qis hauv LDL cov roj (cholesterol) zoo ib yam li cov kev siv atorvastatin tsis muaj zaub mov.

Qhov kev nkag siab ntawm atorvastatin thaum thov thaum yav tsaus ntuj yog qis dua thaum sawv ntxov (kwv yees li 30%). Txoj kab sib txuas ntawm qhov txheeb ze ntawm qhov nqus ntawm qhov nqus thiab qhov tshuaj ntawm cov tshuaj tau qhia tawm. Bioavailability - 14%, lub cev tsis muaj zog ntawm cov kev txwv tsis pub tiv thaiv HMG-CoA reductase - 30%.

Kev siv lub cev tsis tshua muaj txiaj ntsig zoo yog vim cov kab mob (presystemic metabolism) nyob rau hauv cov qog ua pa ntawm lub plab thiab txoj hnyuv (GIT) thiab thaum "thawj tso" los ntawm daim siab. Qhov nruab nrab Vd yog 381 L, kev sib txuas nrog cov ntshav plasma ntau dua li 98%. Nws yog metabolized feem ntau hauv daim siab nyob rau hauv kev ua ntawm isoenzymes CYP3A4, CYP3A5 thiab CYP3A7 nrog kev tsim cov pharmacologically nquag metabolites (ortho thiab para-hydroxylated derivatives, cov khoom ntawm beta oxidation).

Hauv cov tshuaj vitro, ortho- thiab para-hydroxylated metabolites muaj qhov cuam tshuam rau GMK-CoA reductase, piv nrog ntawm atorvastatin. Qhov cuam tshuam ntawm cov tshuaj tawm tsam HMG-CoA reductase yog kwv yees li 70% txiav txim los ntawm cov kev ua ntawm lub cev hloov roj thiab ua mob ntev li 20-30 teev vim lawv muaj. T_1/2 - 14 teev .Nws yog tus neeg nrog kua tsib tom qab hepatic thiab / lossis extrahepatic metabolism (tsis hais lub suab nkag mus rau tus mob). Tsawg dua 2% ntawm kev noj tshuaj hauv qhov ncauj yog txiav txim siab nyob rau hauv cov zis.

Nws tsis yog tawm thaum lub sij hawm hemodialysis vim kev ua kom nruj rau cov ntshav protein.

Nrog lub siab ua tsis tau rau hauv cov neeg mob uas muaj cawv cawv (Me Nyuam-Pyug B), Cmax thiab AUC nce ntxiv (16 thiab 11 zaug, feem ntau).

C_max thiab AUC ntawm cov tshuaj hauv cov neeg laus (65 xyoo rov hauv) yog 40 thiab 30%, feem ntau, ntau dua li cov neeg mob hauv cov neeg laus cov hluas (tsis muaj nqi kuaj mob). Cmax hauv poj niam yog 20% siab dua, thiab AUC yog 10% qis dua tus txiv neej (nws tsis muaj nqi kuaj mob).

Cov hlaws tsis ua haujlwm tsis cuam tshuam rau cov ntshav plasma concentration ntawm cov tshuaj.

- nyob rau hauv kev sib xyaw nrog kev noj haus rau kev kho mob ntawm cov neeg mob kom muaj ntshav ntaug TG (yam IV raws Fredrickson) thiab cov neeg mob dysbetalipoproteinemia (hom III raws Fredrickson), uas kev kho kev noj zaub mov tsis muaj txiaj ntsig,

- nyob rau hauv kev sib xyaw nrog kev noj zaub mov kom txo tau cov theem siab ntawm cov roj (cholesterol) tag nrho, LDL-C, apolipoprotein B thiab TG thiab nce HDL-C hauv cov neeg mob thawj hypercholesterolemia, heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia (hom IIa thiab IIb IIb ),

- txhawm rau txo cov theem ntawm cov roj (cholesterol) tag nrho thiab LDL-C hauv cov neeg mob homozygous tsev neeg hypercholesterolemia, thaum kev noj zaub mov noj thiab lwm txoj kev siv tshuaj tsis zoo muaj txiaj ntsig txaus.

Kev noj tshuaj ntxiv

Ua ntej kev teem caij ntawm Atomax, tus neeg mob yuav tsum pom zoo kom muaj cov lipid-txo cov zaub mov noj, uas nws yuav tsum tau soj ntsuam ntxiv mus kom tag lub sijhawm ntawm kev kho.

Thawj koob tshuaj yog qhov nruab nrab li 10 mg 1 teev / hnub. Cov koob tshuaj nws txawv ntawm 10 txog 80 mg 1 zaug / hnub. Cov tshuaj tuaj yeem siv sijhawm txhua lub sijhawm ntawm hnub nrog zaub mov lossis tsis hais lub sijhawm noj mov. Cov koob tshuaj yog xaiv rau hauv kev txiav txim siab thawj theem ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ib leeg rau ib leeg. Thaum pib kho thiab / lossis thaum qhov nce ntawm Atomax ntau ntxiv, nws yog qhov yuav tsum tau soj ntsuam cov ntshav lipid txhua qib 2-4 lub lis piam thiab kho qhov tshuaj raws li.

Ntawm thawj hypercholesterolemia thiab hyperlipidemia sib xyaw feem ntau, kev teem caij ntawm Atomax hauv ib koob tshuaj 10 mg 1 zaug / hnub txaus. Cov txiaj ntsig kho tau zoo pom tom qab 2 lub lis piam, raws li txoj cai, thiab cov txiaj ntsig kho siab kawg feem ntau pom tom qab 4 lub lis piam. Nrog kev kho mob ntev, cov nyhuv no mob tsawv.

Kev siv cov tshuaj hauv cov neeg mob raum tsis ua haujlwm thiab mob raum tsis cuam tshuam rau theem ntawm atorvastatin nyob rau hauv cov ntshav ntshav lossis qhov degree ntawm qhov txo qis hauv cov ntsiab lus ntawm LDL-C thaum nws siv, yog li ntawd, tsis tas yuav hloov cov koob tshuaj.

Thaum siv cov tshuaj hauv cov neeg laus laus tsis muaj kev sib txawv hauv kev nyab xeeb, kev ua tau zoo, lossis kev ua tiav ntawm hom phiaj kho lipid-txo qis dua piv rau cov pej xeem.

Sab sij huam Cov Atomax

Ntawm qhov txhia chaw: amblyopia, lub suab nrov hauv lub pob ntseg, lub qhov txhab ntawm lub qhov txhab, cuam tshuam ntawm kev pab, qhov muag pom kev tsis txaus, lag ntseg, nce siab intraocular siab, parosmia, perversion ntawm saj, poob ntawm saj hnov.

Los ntawm lub hauv nruab nrab hauv lub paj hlwb thiab lub paj hlwb peripheral: mob taub hau, kiv taub hau, asthenic syndrome, pw tsaug zog lossis tsaug zog, npau suav phem, amnesia, paresthesias, peripheral neuropathy, muaj lub siab xav ua haujlwm, ataxia, hyperkinesis, kev nyuaj siab, hypesthesia.

Los ntawm lub plab zom mov: xeev siab, kub siab, cem quav lossis raws plab, plab zom mov, mob plab, mob plab, mob ntshav qab zib lossis mob ntau dhau, lub qhov ncauj qhuav, duav, mob plab, ntuav, stomatitis, esophagitis, glossitis, gastroenteritis, kab mob siab, mob rau lub plab, mob rau lub plab, mob plab, duodenal mob mob txha nqaj qaum, mob cholestatic daj ntseg, kev ua si ntawm daim tawv nqaij ua paug (AST, ALT), mob tawm ntawm lub qhov ncauj, mob melena, cov pos hniav los ntshav, tenesmus.

Los ntawm cov leeg musculoskeletal: mob caj dab, ceg mob plab, bursitis, mob myositis, mob myopathy, mob caj dab, mob leeg daj, mob rwj leeg, mob caj dab, mob caj dab, mob nraub qaum, nce ntshav ntau ntau CPK.

Los ntawm tus txheej txheem ua pa: mob ntsws, rhinitis, dyspnea, mob ntsws asthma, txhaws ntswg.

Los ntawm cov kab mob zis: mob urogenital, mob rau lub cev txhawm rau mob, ua rau mob plab (suav nrog pollakiuria, nocturia, tso zis tsis tso zis lossis tso zis cia, tso zis tsis tseem ceeb), nephritis, cystitis, hematuria, urolithiasis, albuminuria.

Los ntawm kev muaj me nyuam: qhov chaw mos los ntshav, uterine los ntshav, metrorrhagia, epididymitis, txo qis libido, ua tsis taus pa, ua tsis taus pa, tiv thaiv tsis tau tus mob.

Kev kho kom haum Dermatological: alopecia, tawm hws, eczema, seborrhea, ecchymosis.

Los ntawm cov kab mob plawv: mob hauv siab, mob ntsws, mob ntsws, mob ntshav hauv hlab ntshav, mob ntsws txhaws qav, phlebitis, arrhythmia.

Los ntawm cov kab ke hemopoietic: anemia, lymphadenopathy, thrombocytopenia.

Los ntawm sab ntawm cov metabolism: hyperglycemia, hypoglycemia, qhov hnyav nce, exacerbation ntawm cov hoob kawm ntawm gout, kub cev.

Kev tsis haum tshuaj: mob pruritus, tawv nqaij ua pob, hu rau daim tawv nqaij mob, tsis tshua mob urticaria, angioedema, ntsej muag tawv nqaij, duab tawm, tus mob anaphylaxis, erythema multiforme exudative (suav nrog Stevens-Johnson syndrome), mob ua paug rau mob ua paug (Lyell syndrome).

Cov Yuav Tsum Muaj Cov Atomax

- lub hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim tsa),

- kev mob siab rau daim siab lossis nce siab hauv kev ua haujlwm ntawm cov ntshav transaminases (ntau dua 3 zaug piv nrog VGN) ntawm cov keeb kwm tsis paub,

- Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj.

Nrog ceev faj siv nyob rau hauv cov dej cawv ntev, muaj keeb kwm muaj kab mob siab, mob ntshav qis, tsis txaus, endocrine thiab metabolic ntshawv siab, mob ntshav tawm ntshav, mob hnyav heev (sepsis), mob tsis txaus, kev phais mob ntev ntev, kev raug mob, mob pob txha mob.

Cev xeeb tub thiab lactation

Atomax yog contraindicated nyob rau hauv cev xeeb tub thiab lactation (pub niam mis).

Kuj tsis paub meej tias atorvastatin ua rau niam mis tso. Muab qhov tshwm sim tsis zoo hauv cov menyuam mos, yog tias tsim nyog, kev siv tshuaj thaum lub sijhawm lactation yuav tsum txiav txim siab txog kev txiav kev pub niam mis rau menyuam noj.

Cov poj niam ntawm kev muaj me nyuam hnub nyoog thaum kho yuav tsum siv txoj kev tswj kom tsis muaj menyuam kom txaus. Atorvastatin tuaj yeem kho mob rau cov poj niam uas muaj hnub nyoog yug me nyuam tsuas yog tias qhov tshwm sim ntawm cev xeeb tub muaj tsawg heev, thiab tus neeg mob tau paub txog qhov kev pheej hmoo ntawm kev kho mob rau tus me nyuam hauv plab.

Siv rau lub siab ua haujlwm tsis zoo

Nws yog qhov tsis pom tseeb yog kis mob siab lossis muaj kev nce ntxiv hauv cov dej num ntawm ntshav dej hloov pauv (ntau dua 3 zaug piv nrog VGN) ntawm keeb kwm tsis paub. Siv nrog ceev faj nyob rau hauv ntev cawv, muaj keeb kwm kab mob siab.

Siv rau lub raum tsis zoo muaj nuj nqi

Kab mob hauv lub raum tsis cuam tshuam rau cov tshuaj atorvastatin hauv ntshav ntshav lossis nws cov nyhuv ntawm lipid metabolism. Hauv qhov no, kev hloov pauv koob tshuaj rau cov neeg mob uas lub raum lub raum tsis ua haujlwm tsis tas yuav ua haujlwm. Txawm hais tias kev tshawb fawb hauv cov neeg mob nrog lub davhlau ya nyob twg theem ntawm tus kab mob raum tsis tau ua, hemodialysis tsis zoo li muaj qhov nce ntxiv ntawm kev tshem tawm ntawm atorvastatin, vim nws nquag khi rau plasma proteins.

Kev siv cov tshuaj nyob hauv cov menyuam yaus

Contraindicated: muaj hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim).

Siv rau cov neeg mob laus

Thaum siv cov tshuaj hauv cov neeg laus laus tsis muaj kev sib txawv hauv kev nyab xeeb, kev ua tau zoo, lossis kev ua tiav ntawm hom phiaj kho lipid-txo qis dua piv rau cov pej xeem.

Cov lus qhia tshwj xeeb rau kev txais neeg kawm

Ua ntej pib Atomax txoj kev kho, tus neeg mob yuav tsum tau noj tshuaj kom tsis txhob qoj ib ce hypocholesterol, uas nws yuav tsum ua raws lub sijhawm kho tag nrho.

Kev siv HMG-CoA reductase inhibitors kom txo cov ntshav lipids tuaj yeem ua rau muaj kev hloov pauv hauv cov khoom siv biochemical uas muaj kev cuam tshuam ntawm daim siab ua haujlwm.

Lub siab ua haujlwm yuav tsum tau saib xyuas ua ntej pib txoj kev kho, 6 thiab 12 lub lis piam tom qab pib Atomax thawj coj thiab tom qab txhua koob tshuaj nce, thiab tseem tsis tseg, piv txwv li, txhua 6 lub hlis. Kev nce ntawm kev ua si ntawm hepatic enzymes hauv cov ntshav cov ntshav tuaj yeem pom thaum lub sijhawm kho nrog Atomax. Cov neeg mob nrog kev nce hauv transaminase kev ua haujlwm yuav tsum tau soj ntsuam kom txog thaum lub enzyme rov qab los rau hauv qub. Yog tias qhov tshwm sim ntawm ALT lossis AST yog qhov ntau dua 3 zaug ntau dua li VGN, nws raug nquahu kom txo qis ntawm Atomax lossis tsum tsis kho.

Atomax yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas quav cawv thiab / lossis muaj mob rau daim siab, mob siab lub siab lossis muaj kev cuam tshuam tsis tu ncua ntawm transaminase kev ua haujlwm ntawm cov keeb kwm tsis paub yog qhov sib txuam rau cov tshuaj.

Txoj kev kho Atorvastatin tuaj yeem ua rau myopathy. Kev kuaj mob ntawm myopathy (mob leeg thiab tsis muaj zog ua ke nrog kev nce siab hauv CPK kev ua si los ntawm ntau dua 10 lub sij hawm piv nrog VGN) yuav tsum tau muab siab rau cov neeg mob uas muaj myalgia, mob nqaij los yog tsis muaj zog thiab / lossis cim tau nce hauv CPK cov haujlwm. Cov neeg mob yuav tsum tau ceeb toom tias lawv yuav tsum qhia tus kws kho mob tam sim ntawd txog qhov pom ntawm qhov mob tsis pom los yog tsis muaj zog hauv cov leeg, yog tias lawv nrog mob malaise lossis kub taub hau. Txoj kev kho Atomax yuav tsum tsis ua mus ntxiv yog tias muaj qhov cim tseg hauv CPK cov haujlwm lossis thaum pom tias muaj tus mob myopathy. Txoj kev pheej hmoo ntawm myopathy nyob rau hauv kev kho mob ntawm lwm yam tshuaj ntawm cov chav kawm no tau nce nrog kev siv tib lub sijhawm ntawm cyclosporine, fibrates, erythromycin, niacin lossis azole antifungal cov neeg sawv cev. Ntau ntawm cov tshuaj no inhibit CYP3A4-mediated metabolism thiab / los yog kev thauj. Atorvastatin yog biotransformed los ntawm CYP3A4.Thaum sau tshuaj rau atorvastatin ua ke nrog cov tshuaj fibrates, erythromycin, cov tshuaj tiv thaiv kab mob, azole antifungal tshuaj los yog niacin hauv hypolipidemic doses, qhov kev cia siab thiab txiaj ntsig ntawm kev kho yuav tsum ua tib zoo ntsuas thiab cov neeg mob yuav tsum tau soj ntsuam tsis tu ncua kom paub txog cov leeg mob lossis qaug zog, tshwj xeeb tshaj yog thaum thawj lub hlis ntawm kev kho mob thiab hauv lub sij hawm muab cov tshuaj ntau ntxiv rau ib zaug twg. Hauv cov xwm txheej zoo li no, kev txiav txim siab ib ntus ntawm KFK kev ua si tuaj yeem pom zoo, txawm hais tias kev tswj hwm zoo li ntawd tsis tiv thaiv kev txhim kho kev mob myopathy.

Thaum siv atorvastatin, zoo li lwm yam tshuaj ntawm cov chav kawm no, kis mob ntawm rhabdomyolysis nrog mob raum tsis ua haujlwm vim yog myoglobinuria tau piav qhia. Txoj kev kho Atomax yuav tsum tau txiav tawm ib ntus los sis txiav tawm tag nrho yog tias muaj cov cim qhia tias muaj myopathy lossis muaj kev pheej hmoo rau kev txhim kho lub raum tsis ua haujlwm vim mob rhabdomyolysis (piv txwv li, mob hnyav, mob ntshav qis, kev phais mob loj, mob, mob hnyav, metabolic, endocrine thiab electrolyte cuam tshuam thiab mob tsis nco qab).

Ua ntej pib Atomax txoj kev kho, nws yog ib qho tsim nyog los sim ua kom tau txais kev tswj hwm ntawm hypercholesterolemia los ntawm kev noj zaub mov kom txaus, ua kom lub cev muaj zog, poob phaus hauv cov neeg mob rog thiab kho lwm yam mob.

Cov neeg mob yuav tsum tau ceeb toom tias lawv yuav tsum tau sab laj nrog kws kho mob sai sai yog tias tsis hnov qhov mob lossis cov leeg tsis muaj zog, tshwj xeeb tshaj yog tias lawv nrog mob tshwm sim lossis kub taub hau.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Qhov tshwm sim tsis zoo ntawm Atomax ntawm kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog cov txheej txheem tsis tau qhia.

Noj ntau dhau

Kev Kho Mob: tsis muaj ib qho tshuaj tua kab mob tshwj xeeb, kev kho mob kev ntxhov siab yog nqa tawm. Hemodialysis tsis muaj txiaj ntsig.

Kev sib cuam tshuam nrog Lwm Yam Tshuaj

Txoj kev pheej hmoo ntawm myopathy thaum kho nrog lwm cov tshuaj ntawm cov chav kawm no nce nrog kev siv tib lub sijhawm ntawm cyclosporine, fibrates, erythromycin, cov tshuaj tua kab mob ntsig txog azoles, thiab niacin.

Nrog kev noj ib txhij ntawm atorvastatin thiab kev ncua uas muaj cov khoom siv magnesium thiab aluminium hydroxides, qhov concentration ntawm atorvastatin hauv cov ntshav poob qis txog li 35%, txawm li cas los xij, qhov kev kawm txo qis hauv theem ntawm LDL-C tsis tau hloov pauv.

Nrog rau kev siv tib txhij ntawm atorvastatin tsis cuam tshuam rau pharmacokinetics ntawm antipyrine, yog li ntawd, kev cuam tshuam nrog lwm cov tshuaj metabolized los ntawm tib lub cytochrome isoenzymes tsis xav.

Nrog rau kev siv ua ke ntawm colestipol, ntshav ntau ntawm atorvastatin txo tsawg li thaj tsam 25%. Txawm li cas los xij, lipid-txo cov nyhuv ntawm kev sib txuam ntawm atorvastatin thiab colestipol ntau dua qhov ntawm txhua cov tshuaj ib tus zuj zus.

Nrog kev rov ua dua ntawm cov digoxin thiab atorvastatin ntawm koob tshuaj 10 mg, qhov sib npaug ntawm cov digoxin hauv cov ntshav ntshav tsis hloov. Txawm li cas los xij, thaum digoxin tau siv nrog kev sib xyaw nrog atorvastatin ntawm ib koob ntawm 80 mg / hnub, qhov kev txiav txim siab ntawm digoxin nce ntxiv txog 20%. Cov neeg mob uas tau txais digoxin ua ke nrog atorvastatin yuav tsum pom.

Nrog rau kev siv tib txhij ntawm atorvastatin thiab erythromycin (500 mg 4 zaug / hnub) lossis clarithromycin (500 mg 2 zaug / hnub), uas inhibit CYP3A4, kev nce ntshav ntau dua ntawm atorvastatin tau pom.

Nrog tib lub sijhawm siv atorvastatin (10 mg 1 lub sijhawm / hnub) thiab azithromycin (500 mg 1 lub sijhawm / hnub), cov tshuaj atorvastatin hauv cov ntshav ntshav tsis hloov.

Atorvastatin tsis muaj qhov teeb meem loj hauv lub tsev kho mob rau kev saib xyuas ntawm terfenadine hauv cov ntshav ntshav, uas yog qhov feem ntau metabolized los ntawm CYP3A4; hauv qhov no, nws tsis zoo li atorvastatin muaj peev xwm cuam tshuam loj rau pharmacokinetic tsis muaj lwm yam CYP3A4 substrates.

Nrog kev siv atorvastatin thiab kev noj tshuaj ntau qhov ncauj muaj norethindrone thiab ethinyl estradiol, qhov nce ntxiv ntawm AUC ntawm norethindrone thiab ethinyl estradiol tau tshawb pom los ntawm kwv yees li 30% thiab 20%, feem. Cov nyhuv no yuav tsum raug txiav txim siab thaum xaiv qhov ncauj tawm tsam rau tus poj niam tau txais atorvastatin.

Tsis muaj qhov sib cuam tshuam loj hauv kev kho mob ntawm atorvastatin nrog estrogens tau pom.

Thaum kawm txog kev cuam tshuam ntawm atorvastatin nrog warfarin thiab cimetidine, tsis muaj kev cuam tshuam tseem ceeb hauv chaw kho mob tau pom.

Nrog rau kev siv tib txhij ntawm atorvastatin ntawm koob tshuaj 80 mg thiab amlodipine ntawm koob tshuaj 10 mg, pharmacokinetics ntawm atorvastatin hauv lub xeev equilibrium tsis tau hloov pauv.

Qhov kev siv ntau tshaj tawm ntawm atorvastatin nrog protease inhibitors hu ua CYP3A4 inhibitors tau nrog los ntawm kev nce plasma ntau dua ntawm atorvastatin.

Tsis pom muaj kev mob tshwm sim loj hauv chaw kho mob ntawm atorvastatin thiab cov neeg sawv cev tiv thaiv kab mob siab.

Qhov tshuaj sib txuam nrog tshuaj tsis tau paub.

Cov Cai Siv Tshuaj So

Cov tshuaj yog ntawv yuav tshuaj.

Cov lus thiab cov xwm txheej ntawm kev cia

Sau npe B. Cov tshuaj yuav tsum muab cia kom ncav tsis cuag ntawm cov menyuam yaus, hauv qhov chaw qhuav thiab tsaus ntawm qhov kub ntawm qhov tsis kub tshaj 25 ° C. Txee lub neej yog 2 xyoos.

Kev siv ntawm cov tshuaj atomax tsuas yog raws li kws kho mob tau hais tseg, cov lus qhia tau muab rau siv!

Cov cim qhia dab tsi kom nkag siab tias tus neeg muaj kev puas siab puas ntsws?

Zaum hauv chaw haujlwm txhua hnub? Tsuas yog 1 teev kev tawm dag zog yuav tsis cia koj tuag ua ntej

Dab tsi tshuaj mob plawv yog txaus ntshai rau tib neeg?

Vim li cas tshuab cua txias thiaj ua rau muaj mob?

Puas yog cov kua txiv kua txiv txoj kev uas peb xav txog nws?

Dab tsi tuaj yeem ua tsis tau tom qab noj mov, kom tsis txhob muaj mob rau lub cev

Yuav kho tus mob caj pas: tshuaj lossis lwm txoj hauv kev?

Txog hnub lawm: puas yuav muaj kev cia siab thiab noj qab haus huv zoo dua tom qab 45 xyoos?

Lub Tsev Muag Khoom Nruab Nrab - Laser Tshem Tawm Plaub Hau thiab Pleev Tshuaj pleev ib ce hauv Ukraine

Nco qab tsis muaj menyuam (menyuam yaus) - whim lossis xav tau?

Kev ntsuas rau siv

Tshuaj Cov Atomax nws yog siv rau hauv kev sib xyaw nrog kev noj zaub mov kom txo tau cov theem siab ntawm cov roj (cholesterol) tag nrho, LDL-C, apolipoprotein B thiab TG thiab nce HDL-C hauv cov neeg mob thawj hypercholesterolemia, heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia (hom IIa thiab IIb IIb ), nrog rau kev noj zaub mov noj rau kev kho mob ntawm cov neeg mob uas tau nce qib ntau ntau ntawm TG (yam IV raws Fredrickson) thiab cov neeg mob dysbetalipoproteinemia (hom III raws Fredrickson), hauv kev kho kev noj zaub mov tsis muaj txiaj ntsig zoo, txo qis Nia tag nrho cov roj cholesterol thiab LDL-C nyob rau hauv cov neeg mob uas homozygous familial hypercholesterolemia, thaum noj cov zaub mov kho thiab lwm yam uas tsis yog-pharmacological kev kho mob yog tsis txaus zoo.

Txoj kev ntawm daim ntawv thov

Ua ntej yuav teem caij Cov Atomax tus neeg mob yuav tsum qhia kev noj cov zaub mov lipid-txo qis, uas nws yuav tsum tau ua raws txuas ntxiv thaum lub sijhawm kho.
Thawj koob tshuaj yog qhov nruab nrab li 10 mg 1 teev / hnub. Cov koob tshuaj nws txawv ntawm 10 txog 80 mg 1 zaug / hnub. Cov tshuaj tuaj yeem siv sijhawm txhua lub sijhawm ntawm hnub nrog zaub mov lossis tsis hais lub sijhawm noj mov. Cov koob tshuaj yog xaiv rau hauv kev txiav txim siab thawj theem ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ib leeg rau ib leeg. Thaum pib kho thiab / lossis thaum qhov nce ntawm Atomax ntau ntxiv, nws yog qhov yuav tsum tau soj ntsuam cov ntshav lipid txhua qib 2-4 lub lis piam thiab kho qhov tshuaj raws li.
Nyob rau hauv thawj hypercholesterolemia thiab sib xyaw hyperlipidemia, feem ntau, kev teem ntawm Atomax hauv ib koob tshuaj 10 mg 1 zaug / hnub txaus. Cov txiaj ntsig kho tau zoo pom tom qab 2 lub lis piam, raws li txoj cai, thiab cov txiaj ntsig kho siab kawg feem ntau pom tom qab 4 lub lis piam. Nrog kev kho mob ntev, cov nyhuv no mob tsawv.
Kev siv cov tshuaj hauv cov neeg mob uas lub raum tsis ua haujlwm thiab mob raum tsis cuam tshuam rau theem ntawm atorvastatin nyob rau hauv cov ntshav ntshav lossis cov neeg kawm ntawv poob qis hauv cov ntsiab lus ntawm LDL-C thaum nws siv, yog li ntawd, tsis tas yuav hloov cov koob tshuaj.
Thaum siv cov tshuaj hauv cov neeg mob laus, tsis muaj qhov sib txawv ntawm kev nyab xeeb, kev ua tau zoo lossis kev ua tiav ntawm cov hom phiaj ntawm kev kho lipid-txo qis hauv kev sib piv nrog cov pej xeem.

Yuav ua li cas Siv Atomax nrog cov roj (cholesterol)?

Cov tshuaj yog nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Lawv sab yog convex, nplaim yog ntxhib. Ntawm ib sab muaj kev pheej hmoo. Lawv muaj lub plhaub soluble, muaj qhov txawv ntawm cov xim dawb. Cov ntsiav tshuaj tau ntim rau hauv cov hlwv, uas tau muab ntim rau hauv lub thawv ntawv tuab tuab.

cov tshuaj nquag (cov khoom tseem ceeb), uas yog atorvastatin,
pob kws nplej siab
calcium carbonate
lactose
povidone
croscarmellose sodium,
silicon
anhydrous colloidal dioxide,
crospovidone.

Lub plhaub ntawm cov ntsiav tshuaj ua dab tsi? Los ntawm triacetin, huv talc, primmeloza, titanium dioxide.

Yuav ua li cas haus Atomax, cov lus qhia rau kev siv ntawm uas muaj hauv ntim, txhua tus yuav tsum paub. Qhov no yog qhov lipid-txo cov tshuaj, qhov kev txiav txim ntawm kev tsom mus rau txo qis roj, uas cuam tshuam tsis zoo rau tib neeg lub cev. Tus neeg pab pawg ntawm cov statins. Tsis tas li, cov tshuaj yeeb yaj kiab yog cov sib tw xaiv tau tshuaj tiv thaiv ntawm HMG-CoA reductase. Nws tseem tseem npaj rau lwm lub luag haujlwm: txo qis ntshav lipoproteins ntshav. Atomax muaj txiaj ntsig muaj txiaj ntsig ntawm tsawg lipoproteins uas tsis muaj roj nyob rau ntawm daim siab ua haujlwm.

Raws li kev kho mob, kev tiv thaiv pheej ua ntu zus nyob hauv qhov kev ua haujlwm ntawm LDL receptors tau pom. Nws tsim nyog sau cia kom txo kev pheej hmoo ntawm kev tsim kho thiab tau txais kev cuam tshuam ntawm ischemia.

Cov tshuaj tsis muaj qhov cuam tshuam zoo rau lub cev.

Thaum twg thiaj li tos qhov txiaj ntsig? Txhawm rau kom pom qhov hloov pauv zoo, koj yuav tsum tau noj tshuaj tsawg kawg 2 lub lis piam. Cov tshuaj yuav tsum tau siv nyob ib hlis pib ntawm kev pib kho. Tom qab qhov kev kawm tiav, cov nyhuv yuav pom ntev ntev.

Kev ntsuas rau siv. Atomax yog hauv cov teeb meem xws li:

Cov roj (cholesterol) siab.
Muaj zog LDL-C kom pom tseeb.
Kev nce hauv thyroglobulin thiab apolipropylene B.
Yog qib theem ntawm cov ntshav TG nce ntxiv.
Nyob rau hauv rooj plaub thaum thaum dysbetalipoproteinemia tsim.

Atomax yog qhov tsis muaj txiaj ntsig yog tias tus neeg mob tsis ua raws li kev noj zaub mov tshwj xeeb uas kws kho mob tau sau tseg. Cov tshuaj no yog cov pabcuam thiab ua nrog rau cov khoom noj tshwj xeeb.

Yuav ua li cas noj thiab dab tsi yog qhov ntau npaum ntawm cov tshuaj? Ua ntej pib txoj kev kho mob, tus neeg mob yuav tsum hloov mus rau kev noj zaub mov lipid-tshwj xeeb. Cov kws kho mob pom zoo muab cov koob tshuaj ib leeg zuj zus rau txhua tus neeg mob. Cov tshuaj tuaj yeem noj tau ob qho ua ntej, tom qab, thiab ua ntej noj mov thaum lub sijhawm txhua hnub. Qhov ua tau zoo ntawm cov tshuaj los ntawm qhov no tsis txo qis.

Atomax sib txuas nrog lwm cov tshuaj li cas? Nyob rau hauv rooj plaub thaum thaum cov tshuaj siv ua ke nrog erythromycin lossis antifungal agents, phiv rau hauv daim ntawv ntawm myopia tuaj yeem tshwm sim. Atomax yuav tsum tsis txhob siv rau hauv kev txuas nrog kev ncua uas muaj hydroxide hauv txhuas, txwv tsis pub cov tshuaj atorvastatin hauv cov ntshav txo qis thiab cov txiaj ntsig ntawm kev kho, ntsig txog, kuj.

Terfenadine tuaj yeem siv tau, vim tias cov tshuaj hauv nqe lus nug hnub no tsis hloov pauv cov yam ntxwv ntawm yav dhau los. Nws tuaj yeem siv nrog estrogens - tsis muaj dab tsi loj yuav tshwm sim.

Tsis sib cav nrog Warfarin thiab Cimetidine.

Tsis txhob siv nrog cov tshuaj tiv thaiv protease, vim tias qhov kev sib xyaw no nce qhov kev coj ua ntawm cov tshuaj nquag ntawm Atomax. Nws yog ib qho tsim nyog yuav tsum cais tawm cov tshuaj tiv thaiv kab mob, lossis txo qhov ntau npaum. Qhov no yuav tsum tau ua raws li kev saib xyuas ntawm cov kws kho mob nkaus xwb.

Cov Yuav Tsum Muaj

Cov tshuaj tiv thaiv kom zoo rau kev siv tshuaj Cov Atomax yog: kev mob siab rau daim siab lossis kev nce ntxiv hauv cov dej num ntawm cov ntshav transaminases (ntau dua 3 zaug piv nrog VGN) ntawm cov tsis paub keeb kwm, cev xeeb tub, lactation, hnub nyoog qis dua 18 xyoo (cov hauj lwm zoo thiab kev nyab xeeb tsis tau tsim), ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.
Siv nrog ceev faj nyob rau hauv cov cawv cawv ntev ntev, muaj keeb kwm muaj kab mob siab, mob ntshav qis tsis txaus, endocrine thiab metabolic ntshawv siab, mob ntshav qis, mob hnyav heev (sepsis), mob vwm, kev phais mob ntev, kev raug mob, thiab cov leeg mob pob txha.

Cev xeeb tub

Cov Atomax contraindicated rau siv thaum cev xeeb tub thiab lactation (pub niam mis).
Kuj tsis paub meej tias atorvastatin ua rau niam mis tso. Muab qhov tshwm sim tsis zoo hauv cov menyuam mos, yog tias tsim nyog, kev siv tshuaj thaum lub sijhawm lactation yuav tsum txiav txim siab txog kev txiav kev pub niam mis rau menyuam noj.
Cov poj niam ntawm kev muaj me nyuam hnub nyoog yuav tsum siv txoj kev ua kom muaj txiaj ntsig thaum lub sijhawm kho. Atorvastatin tuaj yeem kho mob rau cov poj niam uas muaj hnub nyoog yug me nyuam tsuas yog tias qhov tshwm sim ntawm cev xeeb tub muaj tsawg heev, thiab tus neeg mob tau paub txog qhov kev pheej hmoo ntawm kev kho mob rau tus me nyuam hauv plab.

Kev cuam tshuam nrog lwm yam tshuaj

Txawm li cas los xij, lipid-txo cov nyhuv ntawm kev sib txuam ntawm atorvastatin thiab colestipol ntau dua qhov ntawm txhua cov tshuaj ib tus zuj zus.
Nrog kev rov ua dua ntawm cov digoxin thiab atorvastatin ntawm koob tshuaj 10 mg, qhov sib npaug ntawm cov digoxin hauv cov ntshav ntshav tsis hloov. Txawm li cas los xij, thaum digoxin tau siv nrog kev sib xyaw nrog atorvastatin ntawm ib koob ntawm 80 mg / hnub, qhov kev txiav txim siab ntawm digoxin nce ntxiv txog 20%. Cov neeg mob uas tau txais digoxin ua ke nrog atorvastatin yuav tsum pom.
Nrog rau kev siv tib txhij ntawm atorvastatin thiab erythromycin (500 mg 4 zaug / hnub) lossis clarithromycin (500 mg 2 zaug / hnub), uas inhibit CYP3A4, kev nce ntshav ntau dua ntawm atorvastatin tau pom.
Nrog tib lub sijhawm siv atorvastatin (10 mg 1 lub sijhawm / hnub) thiab azithromycin (500 mg 1 lub sijhawm / hnub), cov tshuaj atorvastatin hauv cov ntshav ntshav tsis hloov.
Atorvastatin tsis muaj qhov teeb meem loj hauv lub tsev kho mob rau qhov kev sib txawv ntawm terfenadine hauv cov ntshav ntshav, uas yog qhov feem ntau metabolized los ntawm CYP3A4; hauv qhov no, nws tsis zoo li tias atorvastatin muaj peev xwm cuam tshuam loj rau pharmacokinetic tsis muaj lwm yam CYP3A4 substrates.
Nrog kev siv atorvastatin thiab kev noj tshuaj ntau qhov ncauj muaj norethindrone thiab ethinyl estradiol, qhov nce ntxiv ntawm AUC ntawm norethindrone thiab ethinyl estradiol tau tshawb pom los ntawm kwv yees li 30% thiab 20%, feem. Cov nyhuv no yuav tsum raug txiav txim siab thaum xaiv qhov ncauj tawm tsam rau tus poj niam tau txais atorvastatin.
Tsis muaj qhov sib cuam tshuam loj hauv kev kho mob ntawm atorvastatin nrog estrogens tau pom.
Thaum kawm txog kev cuam tshuam ntawm atorvastatin nrog warfarin thiab cimetidine, tsis muaj kev cuam tshuam tseem ceeb hauv chaw kho mob tau pom.
Nrog rau kev siv tib txhij ntawm atorvastatin ntawm koob tshuaj 80 mg thiab amlodipine ntawm koob tshuaj 10 mg, pharmacokinetics ntawm atorvastatin hauv lub xeev equilibrium tsis tau hloov pauv.
Qhov kev siv ntau tshaj tawm ntawm atorvastatin nrog protease inhibitors hu ua CYP3A4 inhibitors tau nrog los ntawm kev nce plasma ntau dua ntawm atorvastatin.
Tsis pom muaj kev mob tshwm sim loj hauv chaw kho mob ntawm atorvastatin thiab cov neeg sawv cev tiv thaiv kab mob siab.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Atomax yog ib cov tshuaj uas tsom rau HMG-CoA reductase, uas ua rau cov roj cholesterol ua ke tsis txaus nyob rau hauv lub siab ua haujlwm. Tsis zoo li statins ntawm thawj tiam, Atomax yog tshuaj ntawm cov khoom siv hluavtaws.

Ntawm kev lag luam pharmacological, ib qho tuaj yeem nrhiav cov tshuaj tsim los ntawm lub tuam txhab Indian HeteroDrags Limited thiab cov nroj tsuag hauv tsev ntawm OJSC NIZHFARM, LLC Skopinsky Pharmaceutical Plant.

Atomax muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb uas puag ncig lub cev nrog convex sab. Los ntawm saum toj no lawv yog them nrog ib zaj duab xis daim nyias nyias.Ib pob muaj 30 ntsiav tshuaj.

Cov ntsiav tshuaj suav nrog 10 lossis 20 mg ntawm cov tshuaj nquag - atorvastatin calcium trihydrate.

Ntxiv nrog rau lub ntsiab tivthaiv, txhua ntsiav tshuaj thiab nws lub plhaub muaj qee qhov nqi:

croscarmellose sodium,
lim talcum hmoov
lactose pub dawb
magnesium stearate,
pob kws nplej siab
calcium carbonate
povidone
silicon dioxide anhydrous colloidal,
crospovidone
triacetin

Ntxiv rau, qee qhov nqi ntawm titanium dioxide nyob hauv qhov npaj.

Tus txheej txheem ntawm kev txiav txim ntawm cov tshuaj nquag

Raws li tau hais ua ntej, lipid-txo cov nyhuv ntawm Atomax tau tiav los ntawm thaiv HMG-CoA reductase. Lub hom phiaj tseem ceeb ntawm cov enzyme no yog los hloov cov methylglutaryl coenzyme A kom mevalonic acid, uas yog qhov ua ntej ntawm cov roj (cholesterol).

Atorvastatin ua rau lub siab ua haujlwm, txo qis ntawm LDL thiab cov roj cholesterol. Nws siv tau zoo los ntawm cov neeg mob kev txom nyem los ntawm homozygous hypercholesterolemia, uas tsis tuaj yeem kho nrog lwm cov tshuaj uas txo cov roj cholesterol. Lub zog ntawm qhov txo qis hauv cov roj (cholesterol) ncaj qha nyob ntawm qhov koob tshuaj ntawm cov khoom tseem ceeb.

Atomax tsis pom zoo kom noj thaum noj mov, zoo li kev noj mov txo tus nqi ntawm kev nqus. Cov tshuaj nquag ua haujlwm yog nqus tau zoo nyob rau hauv cov hnyuv. Cov ntsiab lus siab tshaj plaws ntawm atorvastatin raug pom 2 teev tom qab thov.

Nyob hauv kev cuam tshuam ntawm cov enzymes tshwj xeeb CY thiab CYP3A4, cov metabolism tshwm sim hauv lub siab, vim tias cov tshuaj parahydroxylated tau tsim. Tom qab ntawd cov metabolites raug tshem tawm ntawm lub cev nrog rau cov kua tsib.

Kev taw qhia thiab contraindications rau kev siv tshuaj

Atomax yog siv los txo cov roj (cholesterol). Tus kws kho mob sau ntawv muab tshuaj rau hauv cov tshuaj nrog kev noj zaub mov kom zoo rau kev kuaj mob raws li qhov tseem ceeb tshaj plaws, tsev neeg mob heterozygous thiab tsis nyob hauv tsev.

Kev siv cov ntsiav tshuaj kuj tseem cuam tshuam rau kev paub ntau ntxiv ntawm thyroglobulin (TG), thaum kev noj zaub mov noj tsis nqa cov txiaj ntsig uas xav tau.

Atorvastatin txo cov roj cholesterol hauv cov neeg mob homozygous tsev neeg hypercholesterolemia, thaum tsis yog kev kho tshuaj thiab kev noj haus tsis ua rau lub cev lipid metabolism.

Atomax raug txwv rau qee pawg ntawm cov neeg mob. Cov kev qhia muaj ib daim ntawv teev cov kev tsis sib haum xeeb rau kev siv tshuaj:

Cov menyuam yaus thiab hnub nyoog qis dua 18 xyoo.
Lub sij hawm ntawm kev xeeb tub thiab pub niam mis.
Kab mob siab Hepatic tsis paub meej keeb kwm.
Kev tsis haum xeeb rau cov khoom siv hauv cov khoom.

Cov tshuaj yog sau ntawv nrog kev ceev faj thaum ua rau lub zog ntawm txoj hlab ntshav siab, qhov tsis txaus ntawm electrolytes, kev ua haujlwm tsis zoo ntawm cov endocrine system, daim siab mob pathologies, mob ntev cawv thiab mob vwm, uas tsis tuaj yeem tswj tau.

Cov lus qhia rau kev siv tshuaj

Lub hauv paus tseem ceeb hauv kev kho Atomax yog kev soj ntsuam ntawm kev noj zaub mov tshwj xeeb. Khoom noj khoom haus yog ua rau txo qis cov khoom noj uas muaj cov roj cholesterol siab. Yog li, cov zaub mov tsis suav nrog kev noj viscera (ob lub raum, paj hlwb), qe qe, butter, nqaij npuas muaj roj, thiab lwm yam.

Kev noj tshuaj atorvastatin txawv ntawm 10 txog 80 mg. Raws li txoj cai, tus kws kho mob koom nrog sau ntawv tso cai muab thawj koob tshuaj 10 mg rau ib hnub. Ntau yam ua rau muaj ntau npaum li cas ntawm cov tshuaj, xws li cov qib ntawm LDL thiab cov roj (cholesterol) tag nrho, cov hom phiaj ntawm kev kho thiab nws cov hauj lwm zoo.

Ua kom ntau dua qhov ntau npaum li cas tuaj yeem nqa tawm tom qab 14-21 hnub. Hauv qhov no, kev xav txog cov lipids hauv cov ntshav ntshav yog yuav tsum ua.

Tom qab 14 hnub ntawm kev kho mob, qhov kev txo qis hauv cov qib roj yog pom, thiab tom qab 28 hnub qhov siab tshaj plaws ua tau tiav. Nrog lub sijhawm ntev los kho, lipid metabolism rov zoo li qub.

Cov ntim ntawm cov tshuaj yuav tsum muab cia rau hauv qhov chaw tiv thaiv los ntawm ncaj qha tshav ntuj kom deb ntawm cov menyuam yaus. Qhov ntsuas kub ntawm qhov tso cia nws txawv ntawm 5 txog 20 degrees Celsius.

Txee lub neej yog 2 xyoos, tom qab lub sijhawm no cov tshuaj txwv tsis pub noj.

Tej zaum ua rau mob thiab dhau cai

Kev tswj hwm tus kheej ntawm cov tshuaj rau txoj kev kho cov tshuaj yog nruj me ntsis txwv tsis pub.

Qee zaum, ib qho tshuaj yuav ua rau muaj kev phiv tshuaj nyob hauv tus neeg mob.

Ua ntej siv Atomax, koj yuav tsum sab laj nrog koj tus kws kho mob.

Cov ntaub ntawv qhia hais tias qhov tshwm sim muaj feem ntawm cov kev mob tshwm sim:

Kev tsis sib haum ntawm lub hauv nruab nrab cov hlab ntsha: asthenic syndrome, pw tsis tsaug zog lossis tsaug zog, npau suav phem, qaug zog, dias taub hau, mob taub hau, mob siab, tinnitus, teeb meem kev pab, paresthesia, peripheral neuropathy, saj tsis zoo, qhov ncauj qhuav.
Cov tshuaj tiv thaiv cuam tshuam nrog cov kabmob ntsig txog qhov tsis hnov tsw: kev txhim kho ntawm lag ntseg, lub qhov muag qhuav.
Cov teeb meem ntawm cov hlab plawv thiab cov hlab ntsha ua haujlwm: phlebitis, anemia, angina pectoris, vasodilation, orthostatic hypotension, thrombocytopenia, lub plawv dhia, nce siab tsis txaus.
Kev ua haujlwm ntawm lub plab zom mov thiab lub plab hlaub: kev cem quav, raws plab, xeev siab thiab ntuav, mob plab, mob plab hnyuv tws, ua rau lub plab, ua rau lub siab kub, ua kom muaj roj ntau dua, muaj tus mob ua kom huam sai.
Kev tawm tsam ntawm daim tawv nqaij: khaus, tawm pob, ua viav vias, o ntawm lub ntsej muag, kev zoo nkauj.
Qhov teeb meem ntawm cov leeg mus ntawm lub cev: mob leeg ntawm cov leeg qis, mob hauv kev sib cog lus ntawm pob qij txha thiab sab nraub qaum, mob mob leeg mob, mob rwj mob, mob caj dab, mob exacerbation ntawm gout.
Malfunctioning tso zis: tso zis qeeb, cystitis.
Deterioration ntawm kev kuaj pom: hematuria (ntshav hauv cov zis), albuminuria (protein hauv cov zis).
Lwm yam kev cuam tshuam: hyperthermia, txo qis kev sib deev muaj zog, ua haujlwm erectile kawg, alopecia, tawm hws ntau dhau, seborrhea, stomatitis, cov pos hniav los ntshav, qhov quav, lub paum thiab lub qhov ntswg.

Kev noj tshuaj ntau dua ntawm atorvastatin ua rau muaj kev pheej hmoo mob raum, nrog rau myopathy (kab mob neuromuscular) thiab rhabdomyolysis (mob hnyav ntawm myopathy).

Txog hnub, tsis muaj ib yam tshuaj tshwj xeeb rau cov tshuaj no.

Yog tias cov cim qhia txog kev noj ntau dhau tshwm sim, lawv yuav tsum tau muab tshem tawm. Hauv qhov no, hemodialysis yog qhov ua tsis tau zoo.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj yeeb tshuaj nquag muaj peev xwm hloov tawm ntawm lawv tus kheej sib txawv, vim qhov txiaj ntsig los ntawm kev kho tshuaj ntawm Atomax tuaj yeem ntxiv dag zog lossis qaug zog.

Qhov ua tau ntawm kev cuam tshuam ntawm cov tshuaj ntawm cov tshuaj ntau yam yuav tsum tau hais tias tus neeg mob yuav tsum qhia tus kws kho mob uas koom nrog kev noj tshuaj uas cuam tshuam rau Atomax cov haujlwm.

Hauv cov lus qhia rau kev siv tshuaj hypolipidemic, muaj cov ntaub ntawv tiav txog kev cuam tshuam nrog lwm cov tshuaj.

Ua ke nrog kev kho mob nrog cyclosporine, erythromycin, fibrates thiab antifungal agents (pawg azoles) ua rau muaj kev pheej hmoo ntawm cov kab mob neuromuscular - myopathy.
Hauv kev tshawb nrhiav, kev tswj hwm tib lub sijhawm ntawm Antipyrine tsis ua rau muaj kev hloov pauv tseem ceeb hauv cov tshuaj pharmacokinetics. Yog li ntawd, kev sib txuas ntawm ob qho tshuaj tau tso cai.
Kev siv txig txuas ntawm kev ncua kev txiav txim siab uas muaj magnesium hydroxide lossis aluminium hydroxide ua rau txo qis hauv cov ntsiab lus ntawm atorvastatin hauv ntshav.
Kev sib xyaw ntawm Atomax nrog cov tshuaj txwv tswj uas muaj tinylestradiol thiab norethindrone tsub kom ntau dua AUC ntawm cov feem.
Kev siv tib lub sij hawm ntawm colestipol txo cov theem ntawm atorvastatin. Qhov no nyeg txhim kho cov lipid-txo cov nyhuv.
Atomax tuaj yeem nce digoxin hauv cov hlab ntshav. Yog tias tsim nyog, kev kho mob nrog cov tshuaj no yuav tsum ua raws li kev saib xyuas mob nkeeg.
Cov thawj coj loj ntawm Azithromycin tsis cuam tshuam rau cov ntsiab lus ntawm cov kev nquag ntawm Atomax hauv cov ntshav ntshav.
Kev siv erythromycin thiab clarithromycin ua rau nce qib hauv atorvastatin hauv cov ntshav.
Thaum cov chaw sim tshuaj, tsis pom muaj tshuaj lom ntawm Atomax thiab Cimetidine, Warfarin.
Kev nce qib ntawm cov tshuaj nquag tau pom nrog kev sib txuam nrog cov tshuaj nrog cov tshuaj tiv thaiv protease.
Yog tias tsim nyog, tus kws kho mob tso cai rau koj los sib xyaw Atomax nrog cov tshuaj, uas suav nrog Amplodipine.
Cov kev tshawb fawb txog yuav ua li cas cov tshuaj cuam tshuam nrog cov tshuaj antihypertensive tsis tau ua.

Nrog kev sib xyaw ntawm Atomax nrog estrogens, tsis muaj qhov tshwm sim tsis zoo tshwm sim.

Nqe, tshuaj xyuas thiab analogues

Muaj cov xov xwm me me ntawm qhov ua tau zoo ntawm kev siv Atomax hauv Is Taws Nem. Qhov tseeb yog tias tam sim no, IV tiam statins raug siv rau hauv kev kho mob. Cov tshuaj no muaj qhov nruab nrab noj thiab tsis ua rau muaj kev mob tshwm sim ntau.

Atomax nyuaj txaus los yuav hauv khw muag tshuaj ntawm lub teb chaws vim qhov tseeb tias tam sim no nws yuav luag tsis siv. Qhov nruab nrab, tus nqi ntawm ib pob (30 ntsiav tshuaj ntawm 10 mg) thaj tsam ntawm 385 txog 420 rubles. Yog tias tsim nyog, cov tshuaj yuav tuaj yeem txiav txim online ntawm cov ntaub ntawv lub vev xaib ntawm cov tuam ntxhab.

Muaj ob peb tshuaj xyuas ntawm lipid-txo tus neeg sawv cev ntawm cov ncauj lus thematic. Rau feem ntau, lawv tab tom tham txog qhov tshwm sim ntawm kev phiv tshuaj thaum noj cov tshuaj. Txawm li cas los xij, nyias muaj nyias kev xav.

Vim muaj ntau yam contraindications thiab kev tsis zoo, qee zaum tus kws kho mob sau ib qho lus sau (cov tshuaj uas muaj tib yam tshuaj lom) lossis cov tshuaj analogue (muaj cov sib txawv ntawm cov tshuaj sib txawv, tab sis tsim cov tshuaj zoo sib xws).

Cov lus ua ntxiv ntawm Atomax tuaj yeem muas tau ntawm Lavxias kev ua lag luam tshuaj:

Atovastatin (No. 30 ntawm 10 mg - 125 rubles),
Atorvastatin-Teva (No. 30 rau 10 mg - 105 rubles),
Atoris (No. 30 rau 10 mg - 330 rubles),
Liprimar (No. 10 ntawm 10 mg - 198 rubles),
Novostat (No. 30 rau 10 mg - 310 rubles),
Tulip (No. 30 rau 10 mg - 235 rubles),
Torvacard (No. 30 rau 10 mg - 270 rubles).

Ntawm cov tshuaj tiv thaiv zoo ntawm Atomax, nws yog qhov tsim nyog kom paub qhov txawv ntawm cov tshuaj:

Akorta (No. 30 rau 10 mg - 510 rubles),
Krestor (naj npawb 7 rau 10 mg - 670 rubles),
Mertenil (No. 30 rau 10 mg - 540 rubles),
Rosuvastatin (Zaj 28 ntawm 10 mg - 405 rubles),
Simvastatin (No. 30 ntawm 10 mg - 155 rubles).

Tau ua tib zoo kawm cov tshuaj Atomax, cov lus qhia rau kev siv, nqi, analogues thiab cov tswv yim ntawm cov neeg siv khoom, tus neeg mob, ua ke nrog tus kws tshaj lij uas tuaj koom, yuav muaj peev xwm soberly ntsuas qhov xav tau rau kev noj tshuaj.

Cov ntaub ntawv hais txog statins yog muab hauv video hauv tsab xov xwm no.