Arthrosan Txhaj Tshuaj - Official * Cov Lus Qhia rau Kev Siv

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Cov tshuaj tseem ceeb muaj txiaj ntsig yog pioglitazone hauv ib koob tshuaj ntawm 30 mg. Cov tshuaj ntxiv ntxiv uas ua rau: lactose, magnesium stearate, hyprolose, croscarmellose sodium.

Cov ntsiav tshuaj muab tso rau hauv blister pob ntawm 10 daim.

Hauv 1 pob ntawm cardboard tuaj yeem yog 3 lossis 6 ntawm cov pob khoom no. Tsis tas li, cov tshuaj tuaj yeem pom nyob hauv cov poom polymer (30 ntsiav tshuaj txhua) thiab tib lub fwj (30 daim).

Pharmacological kev txiav txim

Clinical microbiology txheeb cais cov tshuaj no raws li thiazolidinedione derivatives. Cov tshuaj yog xaiv agonist ntawm qee gamma receptors ntawm ib tus neeg isoenzymes.

Hauv cov ntshav qab zib mellitus ntawm yam thib ob, cov tshuaj txo cov insulin tsis kam ntawm daim siab mob.

Lawv tuaj yeem nrhiav tau hauv lub siab, cov leeg thiab cov pob tw adipose. Vim tias kev ua kom muaj zog ntawm cov receptors, qhov hloov tsheb ntawm cov noob hauv uas insulin rhiab heev yog txiav txim siab tau hloov kho sai. Lawv kuj tseem koom nrog kev kho cov ntshav qabzib kom ntau.

Cov txheej txheem ntawm kev zom zaub mov ntawm lipid metabolism kuj rov qab tsis zoo.

Cov theem ntawm tsis kam ntawm cov nqaij peripheral poob qis, uas ua rau kom muaj kev cuam tshuam sai ntawm cov kua dej insulin. Hauv qhov no, qib ntawm hemoglobin hauv cov ntshav cov ntshav yog li qub.

Ntawm cov ntshav qab zib mellitus ntawm yam thib ob, cov kab mob tiv thaiv insulin ntawm daim siab ua haujlwm raug txo qis heev. Qhov no ua rau muaj kev txo qis hauv cov concentration ntawm cov piam thaj hauv ntshav, qib ntawm cov ntshav dej hauv cov ntshav kuj poob qis.

Cov Tshuaj Pharmacokinetics

Tom qab noj cov ntsiav tshuaj ntawm lub plab khoob, qhov siab tshaj plaws ntawm pioglitazone hauv cov ntshav cov ntshav tau pom tom qab ib nrab ib teev. Yog tias koj noj tshuaj tom qab noj mov tas, ces cov txiaj ntsig tiav hauv ob peb teev. Bioavailability thiab khi rau cov ntshav protein yog siab.

Pioglitazone metabolism tshwm sim hauv lub siab. Ib nrab-lub neej yog li 7 teev. Cov tshuaj yeeb tshuaj tawm hauv lub cev yog tawm hauv cov qauv ntawm cov tshuaj lom neeg nrog rau kev tso zis, cov kua tsib thiab cov quav.

Cov tshuaj yeeb tshuaj ntawm Astrozone nthuav tawm hauv cov qauv ntawm cov khoom noj khoom haus sib xyaw nrog cov zis.

Cov Yuav Tsum Muaj

Kev tsis haum rau kev siv tshuaj muaj yees yog:

• hypersensitivity rau lub Cheebtsam
• ntshav qab zib hom 1
• mob ketoacidosis,
• mob hauv lub siab thiab lub raum,
• cev xeeb tub thiab lactation,
• cov me nyuam tsis tau muaj 18 xyoo,

Nrog saib xyuas

Yuav tsum tau ceev faj thaum muab tshuaj rau cov neeg uas muaj keeb kwm ntawm:

• o tuaj
• anemia
• kev cuam tshuam ntawm lub plawv cov leeg.

Nrog ntshav qab zib

Yog tias koj siv cov tshuaj ua ke nrog lwm tus neeg mob hypoglycemic lossis metformin, kev kho mob yuav tsum pib nrog kev noj tshuaj tsawg kawg nkaus, i.e. noj tsis ntau tshaj 30 mg ib hnub twg.

Kev sib xyaw nrog cov tshuaj insulin koom nrog kev siv ib zaug ntawm Astrozone hauv 15-30 mg ib hnub twg, thiab cov koob tshuaj insulin tseem nyob zoo li qub lossis maj mam poob qis, tshwj xeeb tshaj yog cov tshuaj tiv thaiv hypoglycemia.

Sab sij huam ntawm Astrozone

Ua rau muaj ntau cov kev phiv tshuaj, uas tuaj yeem tshwm sim nrog kev haus tsis raws cai los yog kev noj tshuaj kom tsawg.

Astrozone tuaj yeem ua rau lub plawv khiav tsis zoo.

Yuav luag txhua yam, tus neeg mob tau o ntawm cov tshaj plaws. Pom kev tsis txaus ntseeg kuj tseem yuav cuam tshuam nrog kev pauv hauv cov ntshav cov piam thaj, tshwj xeeb thaum pib kho. Hauv qee qhov tsis tshua muaj tshwm sim, txoj kev txhim kho ntawm lub plawv tsis tuaj yeem yog tau.

Cuam tshuam rau lub peev xwm los tswj cov tshuab

Vim hais tias raws li kev siv cov tshuaj no, txoj kev txhim kho ntawm lub qog ntshav qab zib muaj peev xwm ua tau, nrog mob siab rau kiv taub hau thiab tsis xis nyob, koj yuav tsum tsis kam tsav lub tsheb thiab tswj lwm cov txheej txheem tsis yooj yim. Tus mob no tuaj yeem cuam tshuam rau qhov nrawm ntawm kev tawm tsam thiab kev ua kom muaj zog.

Koj yuav tsum tsis kam tsav lub tsheb thaum kho nrog Astrozone.

Cov lus qhia tshwj xeeb

Nrog kev ceev faj, cov tshuaj kho tau raug muab rau cov neeg mob uas muaj kev pheej hmoo ntawm tus mob edema, zoo li hauv kev phais (ua ntej yuav muaj kev phais). Kev mob ntshav khov yuav tshwm sim (cov ntshav hemoglobin tsawg zuj zus feem ntau cuam tshuam nrog kev nce ntshav ntau hauv cov hlab ntsha).

Saib xyuas qib ntawm hypoglycemia yog qhov tsim nyog thaum siv kev kho mob ua ke nrog ketoconazole.

Siv thaum cev xeeb tub thiab lactation

Kev noj cov tshuaj yog contraindicated thaum xeeb tub thiab thaum pub mis. Txawm hais tias nws tau ua pov thawj tias cov tshuaj nquag tsis muaj teebmeem teratogenic txog kev muaj menyuam, nws yog qhov zoo dua los tso tseg kev kho thaum lub sijhawm npaj xeeb tub.

Noj Astrozone ntsiav tshuaj yog contraindicated thaum pub niam mis.

Noj tshuaj tiv thaiv Astrozone

Tsis muaj cov tsos mob ntawm kev haus luam yeeb ntau dhau los ntawm Astrozone tau txheeb pom yav dhau los. Yog tias koj tau noj ib qho tshuaj loj, qhov tshwm sim tsis zoo uas tshwm sim los ntawm kev tsis txaus siab thiab kev txhim kho ntawm cov ntshav qog ntshav qis yuav ua rau phem.

Nyob rau hauv cov ntaub ntawv ntawm cov tsos mob cov yam ntxwv ntawm ib tug overdose, nws yog ib qhov tsim nyog los nqa tawm cov tsos mob kho kom txog rau thaum tag nrho cov tsis zoo siab kiag li tshem tawm tag nrho.

Yog tias hypoglycemia pib tsim kho, kev txhim kho detoxification thiab hemodialysis yuav tsum ua haujlwm.

Yog tias hypoglycemia pib nrog kev siv tshuaj ntau dhau ntawm Astrozone, yuav tsum tau siv tshuaj rau cov leeg (hemodialysis).

Kev cuam tshuam nrog lwm yam tshuaj

Thaum siv nrog cov tshuaj tiv thaiv qhov ncauj, qhov muaj zog txo qis ntawm cov tshuaj tiv thaiv ntawm cov khoom ua kom nquag plias yog pom. Yog li, cov hauj lwm zoo ntawm kev siv tshuaj tiv thaiv yog txo.

Cov txheej txheem ntawm pioglitazone metabolism hauv lub siab yuav luag tag nrho thaum siv ua ke nrog ketoconazole.

Cawv tau zoo

Koj tsis tuaj yeem nqa tawm txoj kev kho nrog siv tshuaj kho mob thiab haus dej haus cawv. Qhov no tuaj yeem ua rau muaj kev cuam tshuam ntau ntxiv rau cov leeg hlwb. Txoj kev pheej hmoo ntawm kev txhim kho dyspeptic tshwm sim. Cov tsos mob ntawm intoxication muaj ntau zuj zus.

Muaj ntau tus lej Astrozone uas zoo ib yam li nws ntawm kev siv tshuaj thiab cov kev kho mob:

• Diab Norm
• Diaglitazone,
• Amalvia
• Pioglar
• Pioglite
• Piouno.

Hnub tas sij hawm

Tsis pub ntau tshaj 2 xyoos txij li hnub ntawm kev tsim khoom tau qhia ntawm pob. Tsis txhob siv hnub tas sij hawm.

Cov lus piv txwv ntawm Astrozone - cov tshuaj Piuno siv tsis tau thaum kawg ntawm lub hnub tas sij hawm siv.

1 ml muaj pes tsawg leeg

Meloxicam - 6.00 mg

Cov neeg siv: meglumine - 3.75 mg, poloxamer 188 - 50.00 mg, tetrahydrofurfuril macrogol (glycofurol) - 100.00 mg, glycine - 5.00 mg, sodium chloride - 3.00 mg, 1 M sodium hydroxide tov - rau ib pH ntawm 8.2-8.9, dej rau kev txhaj tshuaj - txog li 1 ml.

Ib qho ampoule (2.5 ml) muaj 15 mg ntawm meloxicam.

cov kua ua kua ntshiab-daj.

Kev Ntsuam Xyuas Astrozone

Oleg, hnub nyoog 42 xyoos, Penza

Kuv tau mob ntev los ntawm hom 2 mob ntshav qab zib. Ntau yam tshuaj tau sau tseg, tab sis cov txiaj ntsig ntawm lawv tsis siv sijhawm ntev li peb xav tau. Thiab nws tsis tuaj yeem ua kuv tus nqi txhaj tshuaj txhua lub sijhawm. Thiab tom qab ntawd tus kws kho mob qhia kuv kom haus tshuaj Astrozone. Kuv xav tias cov nyhuv ntawm lawv sai sai txaus. Tus mob tam sim ntawd txhim kho. Cov ntshav qab zib cov ntshav qab zib rov qab rov qab zoo li qub hauv ob peb lub lis piam. Hauv qhov no, 1 ntsiav tshuaj txaus rau tag nrho lub hnub. Kuv txaus siab rau lub txiaj ntsig ntawm kev kho mob.

Andrey, 50 xyoo, Saratov

Tus kws kho mob tau sau cov tshuaj Astrozone ntawm 15 mg rau ib hnub vim qhov tseeb tias thaum pib kho muaj kev kuaj mob rau daim siab tsis zoo. Tab sis xws li tsuas tshuaj tsis pab. Tus kws kho mob pom zoo kom nce qhov koob tshuaj rau 30 mg rau ib hnub twg, uas tam sim ntawd tau muab lub txiaj ntsig meej. Raws li kev txheeb xyuas, qhov ntsuas cov piam thaj poob qis. Cov nyhuv siv sijhawm ntev mus txog thaum cov tshuaj tau muab tso tseg. Thaum kev ntsuam xyuas pib mob me ntsis, cov kws kho mob tau sau ntawv yuav tshuaj rau 15 mg ib hnub twg. Cov piam thaj tau yuav luag txog tib theem li yuav luag ib xyoos tam sim no, yog li kuv tsis tuaj yeem hais dab tsi tsis zoo txog tshuaj.

Peter, 47 xyoo, Rostov-on-Don

Cov tshuaj tsis haum. Kuv tsis xav tias muaj kev cuam tshuam dab tsi los ntawm qhov tshuaj thawj zaug ntawm 15 mg. Raws li cov txiaj ntsig ntawm kev tsom xam, kuj tseem tsis muaj kev hloov pauv tshwj xeeb. Sai li cov tshuaj tau nce ntxiv rau 30 mg, qhov xwm txheej dav dav tam sim ntawd zuj zus. Cov neeg mob ntshav qab zib tsawg, tsim muaj cov tsos mob uas tsuas yog ua rau kuv poob siab. Kuv yuav tsum tau hloov cov tshuaj.

Tso tawm daim ntawv, muaj pes tsawg leeg

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm kev daws rau kev tswj hwm intramuscular. Cov tshuaj yog meloxicam raws li cov khoom siv tseem ceeb. 1 ml ntawm kev daws muaj 6 mg ntawm meloxicam.

Raws li cov tshuaj pab yog glycine, sodium hydroxide, glycofurol, sodium chloride, dej rau kev txhaj tshuaj.

Vim nws cov txiaj ntsig xaiv, cov tshuaj nquag ntawm tshuaj tsawg pab txhawb kev txhim kho erosive qhov txhab ntawm lub plab thiab duodenum.

Txoj kev ntawm daim ntawv thov, ntau npaum li cas

Intramuscular cov thawj coj ntawm cov tshuaj yog raug tso cai thaum thawj ob peb hnub ntawm kev kho mob. Yav tom ntej, kev hloov mus rau kev tswj hwm qhov ncauj ntawm cov tshuaj (ntsiav tshuaj) yog qhov pom zoo.

Qhov pom zoo kom noj tshuaj txhua hnub yog los ntawm 7.5 txog 15 mg. Cov koob tshuaj thiab lub sijhawm ntau npaum li cas ntawm cov tshuaj tau txiav txim siab los ntawm tus kws kho mob, coj mus rau hauv tus account qhov tshwm sim ntawm tus kab mob thiab cov yam ntxwv ntawm tus neeg mob lub cev.

Cov neeg mob uas nyob ntawm lub cev hemodialysis thiab muaj keeb kwm ntawm lub raum ua haujlwm tsis zoo hauv lub raum yuav tsum tsis pub ntau tshaj qhov siab noj txhua hnub ntawm 7,5 mg.

Arthrosan tsis pom zoo kom sib xyaw hauv cov tshuaj qub nrog cov tshuaj ntawm lwm pab pawg. Kev tswj hwm qhov quav tshuaj tsis raug cai.

Kev cuam tshuam nrog lwm pab pawg ntawm cov tshuaj

Cov tshuaj no yuav tsum tau siv nrog kev ceev faj heev thaum siv ib txhij nrog cov tshuaj los ntawm cov pab pawg anticoagulants (Warfarin), cov tshuaj tiv thaiv kab mob (Plavix, Clopidogrel), cawv, ntsiav tshuaj corticosteroids (Prednisolone), Fluoxetine, Paroxetine.

Arthrosan yuav tsum tsis txhob siv nrog lwm cov tshuaj los ntawm cov pab pawg ntawm cov tshuaj uas tsis yog tshuaj steroidal.

Nrog rau kev siv ua ke nrog diuretics, txoj kev pheej hmoo ntawm kev tsim lub raum tsis ua haujlwm nce.

Nrog rau kev siv ua ke nrog cov tshuaj los ntawm ntshav siab, lawv cov nyhuv hypotensive yuav qis dua.

Thaum ua ke nrog cov vitamin K, heparin, serotonin reuptake inhibitors, thiab fibrinolytics, qhov txaus ntshai los ntshav ntau dua.

Cov lus qhia ntxiv

Nrog rau kev txhim kho ntawm lub cev ua rau pom tias ua txhaum kev ua haujlwm ntawm lub raum (khaus thiab yaim tawv nqaij, ntuav, tso zis dub, mob rau hauv plab), kev siv tshuaj yuav tsum nres tam sim ntawd thiab sab laj nrog kws kho mob.

Arthrosan tuaj yeem npog cov tsos mob ntawm kev kis mob.

Cov tshuaj no tsis tuaj yeem siv los ua prophylaxis ntawm thrombosis, txawm hais tias nws muaj peev xwm txo qis platelet sib xyaw.

Cov qauv tshuaj ntawm Arthrosan

Cov tshuaj hauv qab no yog cov duab neeg ua noj ntawm Arthrosan: Melox, Amelotex, Mirlox, Mesipol, Movasin, Movalis. Yog tias koj xav hloov cov tshuaj, koj yuav tsum xub sab laj nrog koj tus kws kho mob.

Kev khaws cia ntawm kev txhaj tshuaj Arthrosan yuav tsum nqa tawm hauv qhov chaw tsaus, tiv thaiv los ntawm tshav ntuj ncaj qha, deb ntawm cov menyuam yaus. Cia kub - tsis tshaj 25 degrees.

Pharmacodynamics thiab pharmacokinetics

Yam khoom muaj sia meloxicam- derivative oksikamaCov. Nws muaj cov nyhuv tawm tsam, thaiv kev ua kom zoo nkaujprostaglantins thiab enzyme chicooxygenase-2uas koom nrog lub voj voog arachidonic acid.

Hauv qab ntawm meloxicam, kev ua si mob nqaij nruab nrab thiab permeability leeg tshav ntsatxo qis, braking tshwm sim cov tshuaj tiv thaiv nrog cov dawb radicalsCov. Kev ua kom loog tshwm sim vim qhov txo qis hauv kev ua ntawm kev sib cuam tshuam ntawm prostaglantins thiab cov leeg xaus.

Qhov siab tshaj plaws ruaj khov yog ua tiav hauv peb mus rau tsib hnub. Nws khi zoo rau cov protein plasma (99% thiab siab dua). Metabolizedhauv daim siab, ua rau 4 metabolites. Lawv tsis ua lub luag haujlwm hauv cov txheej txheem pharmacodynamic. Metabolites ua rau cov quav thiab tso quav ntev li 15 mus rau 20 teev.

Kev ntsuas rau siv

hauv kev kho mob monotherapy hauv cov neeg mob (tshwj xeeb tshaj yog cov neeg rog dhau los) uas tsis ua tiav glycemic tswj los ntawm kev ua raws li kev noj haus thiab ua kom lub cev tawm dag zog thiab rau leej twg cov thawj coj ntawm metformin yog contraindicated,

hauv kev sib xyaw nrog metformin hauv cov neeg mob (tshwj xeeb tshaj yog hnyav dhau) uas tsis ua tiav glycemic tswj tiv thaiv keeb kwm ntawm qhov ntau tshaj plaws zam cov tshuaj tiv thaiv ntawm metformin,

nyob rau hauv kev sib xyaw nrog sulfonylurea derivatives nyob rau hauv cov neeg mob uas tsis ua tiav glycemic tswj tiv thaiv keeb kwm ntawm qhov siab tshaj plaws zam koob tshuaj sulfonylurea derivatives thiab rau cov uas cov thawj coj ntawm metformin yog contraindicated,

kev sib xyaw nrog metformin thiab sulfonylurea derivatives nyob rau hauv cov neeg mob (tshwj xeeb tshaj yog cov neeg rog dhau los) uas tsis ua tiav glycemic tswj lub sijhawm ua ke nrog kev kho mob nrog metformin thiab sulfonylurea derivatives,

ua ke nrog cov tshuaj insulin hauv cov neeg mob uas tsis ua tiav glycemic tswj thaum siv cov tshuaj insulin thiab rau leej twg cov thawj coj ntawm metformin yog contraindicated.

Cov lus qhia rau kev siv Arthrosan (Txujci thiab ntau npaum li cas)

Cov ntsiav tshuaj tau noj ib hnub ib zaug, nrog rau zaub mov, ntxuav nrog dej. Qhov pom zoo kom noj txhua hnub yog los ntawm 7.5 mg txog 15 mg, nyob ntawm qhov siv ntawm qhov mob tshwm sim thiab chav kis mob.

Yog tias cov tshuaj tsis tuaj yeem noj lustuaj yeem teem txhaj tshuaj intramuscular.

Txhaj tshuaj ntawm Arthrosan, cov lus qhia rau kev siv

Kev txhaj tshuaj Arthrosan yog saib mob rau tus mob hnyav thaum thawj ob peb hnub ntawm kev mob. Kev siv tshuaj yaj yeeb tsim tawm intramuscularlytob hauv cov ntaub. Cov koob tshuaj txhua hnub yog los ntawm 7.5 txog 15 mg, thiab txoj kev kho yog pib nrog cov koob tshuaj me me thiab nce ntxiv kom txog thaum cov nyhuv xav tau tiav.

Tsis pub tshaj qhov cov tshuaj pom zoo, muaj peev xwm nce qhov kev pheej hmoo ntawm kev phiv.

Cov chaw muag tshuaj

Cov Tshuaj Hauv Tshuaj

Meloxicam yog ib hom tshuaj tsis-tshuaj steroidal (NSAID), yog hais txog derivatives ntawm enolic acid thiab muaj cov nyhuv los tiv thaiv, analgesic thiab antipyretic. Cov lus tshaj tawm los tiv thaiv kev cuam tshuam ntawm meloxicam yog tsim rau ntawm txhua tus qauv ua qauv ntawm kev mob. Tus txheej txheem ntawm kev txiav txim ntawm meloxicam yog nws lub peev xwm los cuam tshuam cov synthesis ntawm prostaglandins, paub tiv thaiv kab mob mediators. Hauv vivo meloxicam inhibits prostaglandin synthesis ntawm qhov chaw ntawm o mus rau ntau dua li tshaj tawm hauv lub plab hnyuv lossis lub raum.

Cov kev sib txawv no ua rau muaj kev xaiv ntau dua nyob rau hauv cyclooxygenase-2 (COX-2) piv nrog cyclooxygenase-1 (COX-1). Ntseeg tau tias inhibition of COX-2 qhia txog kev kho mob ntawm NSAIDs, thaum lub sij hawm inhibition ntawm tas li tam sim no COX-1 isoenzyme yuav yog lub luag haujlwm rau phiv los ntawm lub plab thiab lub raum. Qhov xaiv ntawm meloxicam hauv kev sib raug zoo nrog COX-2 tau lees paub hauv ntau lub tshuab kuaj, ob leeg hauv vitro thiab hauv vivo. Qhov kev xaiv muaj peev xwm ntawm meloxicam rau inhibit COX-2 yog qhia thaum siv nyob rau hauv vitro tib neeg cov ntshav ua kev sim siab.

Nws tau tsim tsa tias meloxicam (ntawm koob tshuaj 7.5 thiab 15 mg) ntau tshaj tawm cov tshuaj tiv thaiv COX-2, ua rau muaj kev cuam tshuam ntau dua ntawm kev tsim cov tshuaj prostaglandin E2 los ntawm lipopolysaccharide (ib qho tshuaj tiv thaiv los ntawm COX-2) dua li ntawm cov khoom lag luam ntawm thromboxane, uas koom nrog cov ntshav coagulation. (cov tshuaj tiv thaiv tswj los ntawm COX-1).Cov teebmeem no tau siv tshuaj ntau. Cov kev tshawb fawb vivo dhau los tau qhia tias meloxicam (ntawm koob tshuaj 7,5 mg thiab 15 mg) tsis muaj kev cuam tshuam ntawm platelet kev sib sau thiab lub sijhawm los ntshav.

Hauv cov kev tshawb fawb soj ntsuam, kev phiv los ntawm txoj hnyuv plab hnyuv (GIT) tag nrho sawv qis dua thaum noj meloxicam 7.5 thiab 15 mg dua li thaum noj lwm yam NSAIDs nrog uas sib piv tau ua. Qhov sib txawv ntawm qhov nquag ntawm cov kev mob tshwm sim los ntawm txoj hnyuv plab feem ntau yog vim qhov tseeb tias thaum noj meloxicam, tsis tshua pom tshwm sim xws li dyspepsia, ntuav, xeev siab, mob plab. Kev nquag ntawm cov perforations nyob rau sab sauv txoj hnyuv, mob rau sab hauv thiab los ntshav, uas tau txuam nrog kev siv meloxicam, muaj qis thiab vam khom rau koob tshuaj.

Cov Tshuaj Pharmacokinetics

Meloxicam yog kiag li yaim tom qab kev tswj hwm intramuscular. Tus txheeb ze kev sib raug zoo nrog piv nrog lub qhov ncauj kev noj qab haus huv yog yuav luag 100%. Yog li, thaum hloov los ntawm txhaj tshuaj mus rau qhov ncauj ntawm koob tshuaj xaiv tsis tas yuav tsum muaj. Tom qab kev tswj hwm ntawm 15 mg ntawm cov tshuaj intramuscularly, qhov siab tshaj plaws ntshav plasma concentration (li 1.6 - 1.8 μg / ml) tau mus txog li ntawm 60 - 96 feeb.

Meloxicam khi zoo heev rau cov ntshav plasma protein, feem ntau nrog albumin (99%). Kev pauj kua rau hauv cov kua dej synovial, cov ntsiab lus hauv cov kua dej synovial yog kwv yees li 50% ntawm ntshav plasma concentration. Qhov ntim ntawm kev faib tawm yog tsawg, kwv yees 11 litres. Cov neeg tsis sib txawv yog 7-20%.

Meloxicam yuav luag txhua qhov teeb meem hauv daim siab nrog rau kev tsim ntawm 4 tus kws kho mob tsis xaj yeeb yam. Lub ntsiab metabolite, 5-carboxy-meloxicam (60% ntawm qhov koob tshuaj), yog tsim los ntawm oxidation ntawm cov tshuaj nruab nrab, 5-hydroxymethylmeloxicam, uas kuj yog tawm, tab sis mus rau qhov tsawg dua (9% ntawm koob tshuaj). Hauv cov kev tshawb fawb hauv vitro tau pom tias CYP2C9 isoenzyme ua lub luag haujlwm tseem ceeb hauv kev hloov pauv hauv cov metabolism no, thiab CYP3A4 isoenzyme ua lub luag haujlwm tseem ceeb ntxiv. Hauv kev tsim ntawm ob lwm metabolites (constituting, ntsig txog, 16% thiab 4% ntawm lub koob tshuaj), peroxidase yog kev koom tes, kev ua si ntawm uas tej zaum ib tus neeg sib txawv. Chaw Sau Ntawv

Nws yog tawm sib npaug los ntawm txoj hnyuv thiab lub raum, feem ntau nyob hauv daim ntawv ntawm metabolites. Hauv daim foos tsis hloov pauv, tsawg dua 5% ntawm qhov tshuaj txhua hnub yog txau nrog quav, nyob hauv cov zis hauv daim ntawv tsis pauv, cov tshuaj pom tsuas yog hauv cov nyiaj kab. Qhov kev tshem tawm nruab nrab ib nrab-lub neej ntawm meloxicam sib txawv ntawm 13 txog 25 teev. Plasma tshem tawm nruab nrab 7-12 ml / min tom qab siv ib zaug xwb. Meloxicam qhia tawm cov kab tshuaj kws tshuaj hauv 7.5-15 mg nrog rau kev tswj hwm intramuscular.

Tsis muaj daim siab thiab / lossis lub raum tsis ua haujlwm

Tsis muaj daim siab ua haujlwm, nrog rau lub raum ua haujlwm tsis zoo, tsis cuam tshuam loj npaum li cov tshuaj pharmacokinetics ntawm meloxicam. Tus nqi ntawm kev tshem tawm meloxicam los ntawm lub cev yog qhov muaj zog ntau dua hauv cov neeg mob uas mob raum tsis ua haujlwm. Meloxicam yuav tsawg dua los khi rau cov ntshav plasma protein hauv cov neeg mob uas mob rau lub raum thaum kawg ua tsis tiav. Hauv cov davhlau ya nyob twg tsis ua haujlwm, qhov nce ntawm qhov ntim ntawm kev faib tawm tuaj yeem ua rau ntau dua ntawm cov meloxicam dawb, yog li ntawm cov neeg mob no cov tshuaj txhua hnub yuav tsum tsis pub tshaj 7,5 mg.

Cov neeg laus piv nrog cov neeg mob hluas muaj cov qauv zoo sib xws. Hauv cov neeg mob laus, qhov nruab nrab ntshav pliav thaum qhov sib luag ntawm lub xeev cov tshuaj pharmacokinetics yog me ntsis qis dua hauv cov neeg mob hluas. Cov poj niam laus muaj qhov zoo dua AUC qhov tseem ceeb (thaj chaw hauv qab-sijhawm nkhaus) thiab kev tshem tawm ntev ib nrab ntawm lub neej, piv nrog cov neeg mob hluas ntawm ob tus neeg.

Tsuas tshuaj thiab tswj hwm

Osteoarthritis nrog mob: 7.5 mg ib hnub twg. Yog tias tsim nyog, cov koob tshuaj no tuaj yeem nce ntxiv rau 15 mg rau ib hnub.

Kev mob caj dab: 15 mg ib hnub twg. Ua raws li cov tshuaj tua nyhuv, qhov tshuaj no tuaj yeem txo kom 7,5 mg ib hnub twg.

Ankylosing spondylitis: 15 mg rau ib hnub. Ua raws li cov tshuaj tua nyhuv, qhov tshuaj no tuaj yeem txo kom 7,5 mg ib hnub twg.

Hauv cov neeg mob uas muaj kev pheej hmoo ntau ntxiv (qhov keeb kwm ntawm lub plab hnyuv, muaj kev pheej hmoo rau cov mob plawv), nws raug nquahu kom pib kho nrog ib koob 7,5 mg ib hnub (saib ntu "Cov Lus Qhia Tshwj Xeeb"). Hauv cov neeg mob uas mob raum tsis zoo ua rau mob hemodialysis, lub koob tshuaj yuav tsum tsis pub tshaj 7,5 mg rau ib hnub.

Cov lus pom zoo dav

Txij li thaum qhov pheej hmoo txaus ntshai tshwm sim nyob ntawm qhov koob tshuaj thiab lub sijhawm kho, tsawg kawg qhov kev siv tau thiab sijhawm siv yuav tsum siv. Qhov siab tshaj plaws pom zoo rau kev noj tshuaj txhua hnub yog 15 mg.

Sib xyaw siv

Koj yuav tsum tsis txhob siv cov tshuaj ib txhij nrog lwm cov NSAIDs. Kev noj tshuaj txhua hnub txhua hnub ntawm Arthrosanros siv nyob rau hauv cov tshuaj sib txawv yuav tsum tsis pub tshaj 15 mg.

Intramuscular cov thawj coj ntawm cov tshuaj yog qhia tsuas yog thaum thawj ob peb hnub ntawm kev kho. Kev kho ntxiv txuas ntxiv nrog kev siv cov ntawv hais ntawm qhov ncauj. Cov koob tshuaj pom zoo yog 7.5 mg lossis 15 mg 1 zaug nyob rau ib hnub, nyob ntawm qhov ntau ntawm qhov mob thiab qhov mob hnyav ntawm cov txheej txheem mob.

Cov tshuaj yog muab los ntawm kev sib sib zog nqus ntawm kev txhaj tshuaj.

Cov tshuaj tsis tuaj yeem muab tshuaj hla dej.

Muab qhov ua tau ntawm kev tsis sib haum ntawm Arthrosan, kev daws teeb meem rau kev tswj hwm intramuscular yuav tsum tsis txhob sib xyaw nrog tib lub koob tshuaj nrog lwm cov tshuaj.

Sab sij huam

Cov kev mob tshwm sim tau piav qhia hauv qab no, kev sib raug zoo ntawm cov uas siv cov tshuaj meloxicam tau suav tias yog ua tau.

Cov kev mob tshwm sim thaum sau tom qab kev siv khoom lag luam, kev sib raug zoo ntawm kev siv cov tshuaj meloxicam tau suav tias yog ua tau, yog cim nrog tus *.

Cov hauv qab no yog siv nyob rau hauv cov txheej txheem cov kab mob hauv nruab nrog cev raws li qhov xwm txheej ntawm kev phiv

ntau zaus (> 1/10),
feem ntau (> 1/100. 1 / 1,000. 1 / 10,000. Kev cuam tshuam los ntawm cov ntshav thiab cov kab mob lymphatic:

Tsis tshua muaj - leukopenia, thrombocytopenia, hloov pauv hauv cov lej ntawm cov ntshav, nrog rau kev hloov hauv cov mis leukocyte.

Lub cev tsis muaj zog tiv thaiv kab mob:

Kev tsis sib haum, lwm yam kev cuam tshuam sai tam sim no *, Tsis pom - anaphylactic shock *, tshuaj tiv thaiv kev tsis haum. Mob Hlwb: Tsis tshua muaj - hloov pauv *,

Tsis tsim - tsis meej pem *, kev ntxhov siab *. Cov kev tsis zoo ntawm lub siab: Feem ntau - mob taub hau, Tsis txaus ntseeg - kiv taub hau, tsaug zog.

Kev ua txhaum ntawm cov plab hnyuv siab raum ntawm lub zeem muag, hnov ​​pob ntseg thiab labyrinth tsis meej: Tsis tuaj yeem - vertigo,

Tsis tshua muaj - pom qhov muag *, qhov tsis pom kev zoo, suav nrog qhov pom kev tsis pom kev *, tinnitus. Ua txhaum ntawm lub plawv thiab cov hlab ntsha:

Ncaj nceeg - kev nce ntshav siab, qhov kev xav ntawm "kev tawm tsam" ntawm cov ntshav mus rau lub ntsej muag, Tsis tshua muaj - lub plawv dhia.

Ua txhaum ntawm lub tshuab ua pa:

Tsis tshua muaj - mob ntsws asthma hauv cov neeg mob ua xua acetylsalicylic acid thiab lwm yam tshuaj NSAIDs.

Kev ua txhaum e / gastrointestinal: Ntau zaus - mob plab, dyspepsia, raws plab, xeev siab, ntuav,

Hnyav yooj yim - latent lossis pom meej txoj hnyuv los ntshav, gastritis *, stomatitis, cem quav, tsam plab, belching, Tsis tshua muaj - mob plab hnyuv, colitis, esophagitis, Tsis tshua muaj - perforation ntawm txoj hnyuv huam. Kev ua txhaum ntawm daim siab thiab kab mob:

Tsis tshua muaj tshwm sim - cov kev hloov pauv ntawm daim siab ua haujlwm siab (piv txwv li, kev ua ub no ntau ntxiv ntawm transaminases lossis bilirubin), Muaj tsawg kawg - kab mob siab *.

Kev tsis sib haum xeeb ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: Ncaj ncees - angiotek *, khaus, tawv nqaij ua pob,

Tsis tshua muaj tshuaj lom epidermal necrolysis *, Stevens-Johnson syndrome *, urticaria,

Tsis tshua muaj heev - ua rau daim tawv nqaij dermatitis *, erythema multiforme *, Tsis pom - photosensitivity.

Ua txhaum ntawm ob lub raum thiab lub plab:

Ua tsis tau - kev hloov pauv ntawm qhov ntsuas ntawm lub raum kev ua haujlwm (nce hauv creatinine thiab / lossis urea hauv cov ntshav), tso zis tsis meej, nrog rau mob tso zis ceev *,

Tsis tshua muaj heev - mob raum tsis zoo *.

Ua txhaum ntawm lub qau thiab cov qog mammary:

Ncaj nceeg - ov ovulation *,

Tsis tsim - mob ntxiv hauv cov poj niam *.

Kev cuam tshuam dav dav thiab cuam tshuam ntawm qhov chaw txhaj tshuaj:

Feem ntau - mob thiab o ntawm qhov chaw txhaj tshuaj,

Kev siv sib xyaw nrog cov tshuaj uas thaiv cov leeg pob txha (piv txwv li methotrexate) tuaj yeem ua rau mob cytopenia.

Txoj hnyuv los ntshav, voos, los yog perforation yuav ua tau kom neeg tuag taus.

Raws li rau lwm cov NSAIDs, lawv tsis suav txoj hauv kev muaj qhov tshwm sim ntawm interstitial nephritis, glomerulonephritis, lub raum medullary necrosis, nephrotic syndrome.

Kev cuam tshuam nrog lwm yam tshuaj

Lwm yam tshuaj tiv thaiv ntawm kev sib txuas prostaglandin, suav nrog glucocorticoids thiab salicylates, sib txuas nrog kev siv meloxicam ua rau muaj kev pheej hmoo ntawm kev mob plab hauv lub plab thiab lub plab zom mov (vim yog cov haujlwm los ntawm kev txiav txim siab). Tsis pom zoo siv nrog NSAIDs. Anticoagulants rau kev tswj hwm ntawm qhov ncauj, heparin rau kev siv kab ke, cov kab mob thrombolytic - ib txhij tswj hwm nrog meloxicam tsub kom muaj ntshav txaus. Nyob rau hauv kev cuam tshuam ntawm kev siv tib lub sijhawm, ua tib zoo saib xyuas cov ntshav coagulation system yog qhov tsim nyog.

Antiplatelet tshuaj, serotonin reuptake inhibitors, siv cov tshuaj tiv thaiv nrog meloxicam ntau qhov kev pheej hmoo ntawm los ntshav vim yog inhibition ntawm platelet muaj nuj nqi. Nyob rau hauv kev cuam tshuam ntawm kev siv tib lub sijhawm, ua tib zoo saib xyuas cov ntshav coagulation system yog qhov tsim nyog.

Kev npaj lithium - NSAIDs nce qib ntawm cov lithium hauv ntshav los ntawm kev txo nws cov paug tawm los ntawm lub raum. Kev siv ua ke ntawm meloxicam nrog lithium npaj tsis pom zoo. Yog tias tsim nyog, kev siv tib lub sij hawm los ua tib zoo saib xyuas kev saib xyuas ntawm cov ntse ntawm lithium hauv cov ntshav thoob plaws hauv chav kawm ntawm cov roj ntsha lithium.

Methotrexate - NSAIDs txo qis kev zais ntawm methotrexate los ntawm ob lub raum, yog li ua rau nws cov tshuaj lom neeg ntshav ntau dua. Kev siv tib lub sijhawm ntawm meloxicam thiab methotrexate (ntawm kev noj ntau dua 15 mg ib lis piam) tsis pom zoo. Yog tias siv tib lub sijhawm, ua tib zoo saib xyuas lub raum kev ua haujlwm thiab cov ntshav suav yog tsim nyog. Meloxicam yuav nce hematologic toxicity ntawm methotrexate, tshwj xeeb tshaj yog rau cov neeg mob uas lub raum tsis ua haujlwm.

Tshuaj Txau - muaj pov thawj pom tias NSAIDs yuav txo qis qhov ua haujlwm ntawm cov khoom siv hauv tsev, tab sis qhov no tsis tau muaj pov thawj.

Diuretics - siv cov NSAIDs thaum lub cev qhuav dej ntawm cov neeg mob yog nrog cov kev pheej hmoo ntawm mob tsis zoo rau lub raum.

Cov tshuaj tiv thaiv kab mob siab (beta-blockers, angiotensin-hloov enzyme inhibitors, vasodilators, diuretics). NSAIDs txo cov nyhuv ntawm cov tshuaj tiv thaiv kabmob, vim yog inhibition of prostaglandins nrog vasodilating zog.

Angiotensin II receptor antagonists, zoo li angiotensin-hloov enzyme inhibitors thaum siv ua ke nrog NSAIDs, nce qhov txo qis ntawm glomerular pom, uas tuaj yeem ua rau kev txhim kho ntawm lub raum tsis ua haujlwm, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas tsis zoo lub raum kev ua haujlwm.

Colestyramine, khi rau meloxicam hauv txoj hnyuv plab, ua rau nws nthuav tawm sai dua.

Pemetrexed - nrog kev siv tshuaj meloxicam thiab pemetrexed hauv cov neeg mob uas muaj kev tshem tawm 45 mus rau 79 ml / min, meloxicam yuav tsum tau txiav tsib hnub ua ntej pib pemetrexed thiab tuaj yeem rov pib dua 2 hnub tom qab kawg ntawm qhov muab tshuaj. Yog tias muaj qhov xav tau ntawm kev siv tshuaj meloxicam thiab pemetrexed, ces cov neeg mob zoo li no yuav tsum tau saib xyuas zoo, tshwj xeeb tshaj yog hais txog myelosuppression thiab qhov tshwm sim ntawm kev phiv los ntawm txoj hnyuv hauv lub plab. Hauv cov neeg mob nrog creatinine tshem tawm tsawg dua 45 ml / min, noj meloxicam ua ke nrog pemetrexed tsis pom zoo.

NSAIDs, ua yeeb yam rau lub raum prostaglandins, tuaj yeem txhim kho cyclosporin nephrotoxicity.

Thaum siv nrog rau cov tshuaj meloxicam uas paub tias muaj peev xwm los tiv thaiv CYP 2C9 thiab / lossis CYP ZA4 (lossis cov metabolized los ntawm cov enzymes), xws li sulfonylureas lossis probenecid, qhov muaj peev xwm ntawm kev sib raug zoo ntawm pharmacokinetic yuav tsum raug suav. Thaum ua ke nrog cov tshuaj tiv thaiv kab mob rau kev tswj hwm qhov ncauj (piv txwv li, sulfonylurea derivatives, nateglinide), kev sib cuam tshuam los ntawm CYP 2C9 yog qhov ua tau, uas tuaj yeem ua rau muaj kev nce ntxiv ntawm cov tshuaj ntawm ob cov tshuaj thiab meloxicam hauv cov ntshav. Cov neeg mob uas siv tshuaj meloxicam nrog sulfonylurea lossis kev npaj tshuaj yuav tsum tau ua tib zoo saib xyuas lawv cov ntshav qab zib vim qhov muaj peev xwm ua kom muaj qog ntshav qab zib.

Nrog rau kev siv tib lub sijhawm ntawm antacids, cimetidine, digoxin thiab furosemide, tsis muaj kev cuam tshuam tseem ceeb ntawm pharmacokinetic.

Tsuas tshuaj thiab tswj hwm

Kev hno nrog Arthrosan tsuas yog siv hauv thawj ob peb hnub ntawm kev kho mob ib hnub ib zaug, ntawm 7,5 lossis 15 ml, tom qab ntawd kho tau txuas nrog ntsiav tshuaj ntxiv. Vim tias qhov kev pheej hmoo ntawm qhov tshwm sim, nws tau pom zoo kom siv cov tshuaj hauv kev siv tshuaj tsawg kawg. Kev hno nrog Arthrosan yuav tsum tau txhaj tshuaj nkaus xwb yog cov tshuaj intramuscularly thiab nws tsis pom zoo kom sib xyaw cov tshuaj hauv ib qho syringe nrog lwm cov tshuaj.

Arthrosan ntsiav tshuaj noj ib hnub ib zaug, nyiam dua nrog zaub mov noj. Qhov siab tshuaj ntau tshaj txhua hnub yog 15 mg. Tsuas tshuaj yog nyob ntawm tus kab mob:

• Nrog osteoarthrosis, noj ib ntsiav tshuaj ntawm Artrozan 7,5 mg, thaum tsis muaj txiaj ntsig, qhov koob tshuaj yuav ua tau ob npaug,
• Cov koob tshuaj pom zoo txhua hnub rau mob caj dab rheumatoid yog 15 mg, tom qab kev txhim kho, qhov tshuaj yuav txo tau kom 7,5 mg ib hnub twg,
• Nrog ankylosing spondylitis, noj ib ntsiav tshuaj ntawm Arthrosan 15 mg ib hnub twg.

Raws li cov lus qhia rau Arthrosan, yog tias muaj kev noj ntau dhau, mob epigastric, tsis nco qab, xeev siab, ua pa ntes, ntuav, mob raum thiab mob rau lub siab, asystole yuav tshwm sim.

Ceev faj yuav tsum tau siv thaum siv Arthrosan nrog cov tshuaj tiv thaiv kabmob, methotrexate, diuretics, cyclosporine, lithium npaj thiab qee yam tshuaj ntxiv. Txoj kev pheej hmoo los ntshav los ntawm lub plab zom mov ntxiv nrog rau kev siv Arthrosan tib txhij nrog lwm cov tshuaj tsis haum steroidal, suav nrog acetylsalicylic acid.

Arthrosan tau siv nrog ceev faj thaum muaj qhov nqaij tawv thiab mob txhab ntawm lub plab zom plab hauv anamnesis thiab hauv hnub nyoog laus.

Kev txheeb xyuas txog Arthrosan

Kev txheeb xyuas txog kev txhaj tshuaj ntawm Arthrosan yog qhov zoo. Cov tshuaj yog qhov pheej yig thiab siv tau zoo heev. Ntau tus tau pab daws kev mob nrog ntau yam mob sib koom tes. Kev noj tshuaj muaj cov nyhuv tib yam li kev txhaj tshuaj. Ntawm cov minuses, cov kev mob tshwm sim tau sau rau hauv daim ntawv ntawm mob taub hau, mob plab thiab kiv taub hau, tab sis qhov no tshwm sim dhau los.