Ntev mob ntshav qab zib mellitus: tsom rau pentoxifylline

Ntev mob ntshav qab zib mellitus ua rau txo qis lub sijhawm thiab lub neej zoo ntawm cov neeg muaj tus kab mob no. Them rau cov ntshav qab zib yog qhov nyuaj rau qhov ua tiav thiab kom deb li deb tau los tiv thaiv kev txhim kho thiab kev loj hlob ntawm cov teeb meem. Muab cov pathogenesis ntawm cov teeb meem mob ntshav qab zib mellitus, nws raug nquahu kom siv cov tshuaj tua kabmob, uas suav nrog cov tsis muaj kev xaiv phosphodiesterase blocker pentoxifylline, uas muab cov kev sib xyaw ua ke ntawm cov hlab ntsha tsis muaj zog, tus kabmob antiplatelet thiab angioprotector. Kev soj ntsuam ntawm cov txiaj ntsig ntawm kev siv pentoxifylline nyob rau hauv ntau yam mob ntev ntev ntawm ntshav qab zib mellitus yog nthuav tawm.

Ntev mob ntshav qab zib mellitus: tsom rau pentoxifylline

Tus mob ntshav qab zib mob ntev ntev yog tshwm sim los ntawm kev txo qhov ntev thiab lub neej zoo ntawm cov neeg muaj tus kab mob no. Cov nyiaj them los ntawm ntshav qab zib yog qhov nyuaj rau ua tiav thiab tsis pub tiv thaiv lawv txoj kev loj hlob thiab kev vam meej. Coj mus rau hauv lub zej zog ntawm pathogenesis ntawm kev mob ntshav qab zib, kev siv ntawm kev npaj ntawm qhov kev ua haujlwm rau qhov uas tsis xaiv blocker ntawm phosphodiesterase pentoxifylline sib txuas cov teebmeem ntawm qhov tsis muaj zog peripheral vasodilator, antiplatelet tus neeg sawv cev thiab angioprotectora. Kev soj ntsuam ntawm kev ua tau zoo ntawm kev siv pentoxifylline ntawm ntau cov teeb meem mob ntshav qab zib tau nthuav tawm.

Cov ntawv luam ntawm cov ntawv pov thawj scientific ntawm lub ncauj lus "Mob nyhav ntev ntev ntawm ntshav qab zib: tsom rau pentoxifylline"

TEJ YAM LICAS THIAB SAIB XYUAS THIAB

Mob ntshav qab zib mob ntev ntev: tsom rau pentoxifylline

kws kho mob ntawm kev kho mob sciences, xib fwb ntawm 1 lub chaw haujlwm ntawm cov kab mob sab hauv ntawm Belarusian State Medical University

MokhortT. Belarusian State Medical University, Minsk Cov teeb meem mob ntshav qab zib mellitus:

mob siab rau pentoxifylline

Ntsiab lus Ntev mob ntshav qab zib mellitus ua rau txo qis lub sijhawm thiab lub neej zoo ntawm cov neeg muaj tus kab mob no. Them rau cov ntshav qab zib yog qhov nyuaj rau qhov ua tiav thiab kom deb li deb tau los tiv thaiv kev txhim kho thiab kev loj hlob ntawm cov teeb meem. Muab cov kab mob tseem ceeb ntawm cov teeb meem mob ntshav qab zib mellitus, nws raug nquahu kom siv cov tshuaj muaj zog, uas suav nrog cov tsis muaj kev xaiv phosphodiesterase blocker - pentoxifylline, uas muab cov kev sib xyaw ua ke ntawm cov hlab ntsws tsis muaj zog, tus neeg sawv cev antiplatelet thiab angioprotector. Kev soj ntsuam ntawm cov txiaj ntsig ntawm kev siv pentoxifylline nyob rau hauv ntau yam mob ntev ntev ntawm ntshav qab zib mellitus yog nthuav tawm.

Cov ntsiab lus tseem ceeb: mob ntshav qab zib mellitus, mob nyhav, pentoxifylline, mob ntshav qab zib retinopathy, ntshav qab zib nephropathy, kev txawj ntse, kev ua haujlwm tsis muaj dej cawv, lub siab tsis ua haujlwm.

Xov xwm kho mob. - 2015. - No. 4. - S. 4-9.

Ntsiab lus Tus mob ntshav qab zib mob ntev ntev yog tshwm sim los ntawm kev txo qhov ntev thiab lub neej zoo ntawm cov neeg muaj tus kab mob no. Cov nyiaj them los ntawm ntshav qab zib yog qhov nyuaj rau ua tiav thiab tsis pub tiv thaiv lawv txoj kev loj hlob thiab kev vam meej. Coj mus rau hauv lub zej zog ntawm pathogenesis ntawm kev mob ntshav qab zib, siv kev npaj ntawm qhov kev txiav txim ntawm cov txheej txheem uas tsis xaiv kev thaiv phosphodiesterase - pentoxifylline sib txuas cov teebmeem uas tsis muaj zog peripheral vasodilator, antiplatelet tus neeg sawv cev thiab angioprotectora. Kev soj ntsuam ntawm kev ua tau zoo ntawm kev siv pentoxifylline ntawm ntau cov teeb meem mob ntshav qab zib tau nthuav tawm.

Cov ntsiab lus tseem ceeb: mob ntshav qab zib mellitus, mob nyhav, pentoxifylline, mob ntshav qab zib retinopathy cov ntshav qab zib nephropathy, kev ua haujlwm ntawm lub cev, tsis yog dej cawv muaj kab mob, lub plawv tsis ua haujlwm.

Meditsinskie novosti. - Xyoo 2015. - N4. - P. 4-9.

Ntev mus ntev, lossis lig, muaj teeb meem ntawm cov ntshav qab zib mellitus (DM) yog qhov ua rau txo qis ntawm lub sijhawm thiab lub neej zoo ntawm cov neeg uas muaj tus kab mob no. Kev lig kev cai, lub sijhawm ntawm kev mob tshwm sim suav nrog microangiopathies (retinopathy, nephropathy), neuropathy thiab macroangiopathies (atherosclerosis ntawm cov hlab ntshav hlab ntsha nrog kev txhim kho mob rau cov hlab ntshav txhaws, mob hlwb thiab lwm cov hlab ntsha). Xyoo tsis ntev los no, ntau qhov kev tso npe ntawm cov neeg tsis muaj cawv rog lub siab nyob hauv kev rog thiab hom ntshav qab zib hom 2 tau sib tham, uas tso cai rau peb koom nrog cov kab mob no nrog cov mob ntev ntev ntawm ntshav qab zib. Qhov ntau yog ntawm cov kev puas hlwb thiab dementia tseem kos xim, uas actualizes xav tau los tsim txoj kev mus rau lawv txoj kev kho mob.

Ntau cov kev tshawb fawb tau txheeb pom qhov kev pheej hmoo txaus ntshai rau kev txhim kho ntawm kev mob nyhav (mob ntshav qab zib, mob ntshav qab zib, mob ntshav qab zib) thiab txheeb xyuas cov txheej txheem rau kev tiv thaiv thiab kho kev mob ntshav qab zib. Kev ntsuas kab mob ntawm cov kev tshawb fawb ntsuas qhov tshwm sim ntawm cov txiaj ntsig ntawm cov nyiaj them rau cov metabolism hauv kev rog, ua kom ntshav khov thiab lipid profile tau pom.

txo txoj kev pheej hmoo ntawm kev tsim cov kev mob lig, tab sis, hmoov tsis, tsis yog lawv tag nrho kev tiv thaiv thiab kho. Pom tseeb, ntau yam xwm txheej ntawm lub pathogenesis ntawm cov ntshav qab zib muaj teeb meem txiav txim siab xav tau cov kev ntsuas ntxiv los cuam tshuam cov txheej txheem mob ntawm angio- thiab neuropathies. Tau ntau xyoo, nws tau siv ua tshuaj rau kev kho mob thiab tiv thaiv cov teeb meem vascular ntawm ntshav qab zib.

tsis muaj xim xaiv phosphodiesterase blocker - pentoxifylline (PF), sib txuas cov teebmeem ntawm cov hlab ntsws tsis muaj zog, cov tshuaj tiv thaiv kab mob thiab angioprotector. PF tau tsim tawm hauv xyoo 1965 yog cov tshuaj los ntawm ntau tus methylxanthines nrog vasodilating thaj chaw. Tom qab kev txiav txim siab thiab kuaj mob hauv xyoo 1972, ntawm kev tawm tswv yim ntawm Grigoleit thiab Werner, cov tshuaj pib tau pib siv hauv chaw soj ntsuam

Tus kab mob ntshav qab zib lig

General Theory ntawm Ntshav Qab Zib Teeb meem (Brownlee M.) Fonseca V.A. Soj ntsuam ntshav qab zib txhais kev tshawb fawb txog kev tshawb fawb txog xyoo 2006

t Collagen t Fibronectin

Ua txhaum Txoj Cai. Kev nyob ib leeg ntsiag to Tsis txaus siab yuav muaj tus mob. ntau yam noob

ntshav ntws angiogenesis ntawm cov hlab ntsha capillaries cuam tshuam

1Я1Н Kev mob ib ce thiab kab mob ntawm pentoxifylline

Lub zog tseem ceeb Lwm yam khoom siv ntawm lub cev

Kev Tiv Thaiv Ntshav Kev Ntshav Los Ntawm Cov Roj ntshav kho qhov nqaij zoo

Ntshav viscosity thiab ntshav khiav

Erythrocyte deformation peev xwm + +

¿Kev sib sau ntshav ntshav fibrinogen + + +

Kev txiav txim siab muaj peev xwm ntawm leukocytes + + +

Cov kab sib dhos thiab sib sau ua ke ntawm leukocytes + + + +

Kev zais ntawm superoxides los ntawm neutrophils + + +

Lub ntsiab ntawm neutrophils FAT + + +

¿Kev Tsim TNF-a monocytes + +

Uk Leukocyte teb rau TNF-a + +

Uk Leukocyte teb rau IL-2 +

Killer Natural killer kev ua +

Ntshav coagulation thiab fibrinolysis

Ntaub so ntswg plasminogen activator + +

Cov qhov txhab mob zoo thiab cov ntaub so ntswg sib txuas

Teb rau TNF-a fibroblasts +

NCO TSEG: FAT yog lub platelet ua kom tau + + yog qhov tshwm sim zoo, | - nce, - txo.

xyaum los txhim kho cov txheej txheem hauv microvasculature.

Lub tshuab ntawm kev ua ntawm PF pom tau los ntawm kev nce hauv cov ntsiab lus ntawm c-AMP thiab ATP thiab kev txo qis hauv kev noj cov calcium hauv lub cell. Raws li qhov tshwm sim ntawm PF:

- nce plasticity ntawm lub cell membrane ntawm cov qe ntshav liab thiab txo cov neeg kawm ntawv ntawm deformability,

- txo qis kev ua haujlwm ntawm cov ntshav liab,

- muaj cov nyhuv vasodilating tsis muaj zog,

- txo cov ntshav viscosity (nce siab fibrinolysis thiab txo fibrinogen concentration),

- txo cov platelet aggregation,

- tshem tawm cov kev puas tsuaj ntawm neutrophils ntawm endothelium.

Cov yam ntxwv tau teev tseg yog qhov tseeb tshwj xeeb rau cov ntshav qab zib, txij li nce qib ntawm glycated hemoglobin nyob rau hauv ntev hyperglycemia hloov thaj chaw them nyiaj ntawm cov ntshav liab thiab ua rau lawv cov kev nplaum thiab txo qis hauv deformability.

Vim nws cov qauv tshuaj, PF muaj lub peev xwm nce prostacyclin synthesis thiab txo qhov tsim ntawm thromboxane A2 hauv hlwb endothelial, inhibit cov synthesis ntawm cov qog necrotic factor-a (TNF-a) thiab lwm yam cytokines, hloov ntshav plasma fibrinogen concentration thiab cov haujlwm ntawm plasminogen activator inhibitor, thaiv phosphodiesterase, uas ua rau kom muaj kev txuam nrog cAMP 17, 32, 35, 39 hauv platelets. Tag nrho cov teebmeem no tiv thaiv kev ua kom tsis taus ntawm cov platelets thiab cov ntshav liab, uas cuam tshuam loj heev ntawm cov rheological Ntshav khoom.

Lub caj ces caj ces muaj zog ntawm PF tau muab nyob rau hauv lub rooj. Ntau tshaj plaub caug xyoo ntawm kev paub nrog kev siv PF (nyob rau hauv tag nrho cov kev tshawb fawb thawj daim ntawv ntawm PF - Trental tau siv) qhia nws cov hauj lwm zoo hauv ntau cov pathologies, tab sis, tsom mus rau mob ntshav qab zib, peb txheeb xyuas cov kev muaj peev xwm ntawm kev siv PF rau ntau cov mob ntev.

Cov kab mob sib xyaw ua ke ntawm cov hlab ntsha ntawm qhov qis qis (HOSANK) yog qhov ua rau ntawm kev txhim kho ischemic thiab sib xyaw ntawm cov mob ntshav qab zib taw. Tsis muaj kev ntseeg tias cov kev kho mob yooj yim yog los ntawm kev kho kom rov qab los ntawm cov ntshav txaus hauv cov hlab ntsha, i.e. angiosurgical kev cuam tshuam nyob rau hauv qhov muaj qhov tseem ceeb stenosis. Kev tiv thaiv thiab kho cov kev tawm tsam suav nrog, ntxiv rau feem ntau lees txais cov lus pom zoo (them nyiaj rau cov khoom noj ntawm lub cev carbohydrate,

dyslipidemia, ib txwm muaj ntshav siab), ntxiv. Cov lus qhia ntxiv:

- kev haus luam yeeb tsis txaus, kev ua haujlwm ntawm lub cev (nyob rau ntawm qhov tsis sib haum xeeb ntawm 45-60 feeb taug kev kom txog thaum hnov mob nrog so nrog lub voj voog ntawm 3 zaug hauv ib lub lis piam),

- antiplatelet thiab antithrombotic cov neeg sawv cev - tshuaj aspirin los yog thienopyridines (ticlopidine lossis clopidogrel) lossis platelet receptor glycoprotein IIb / IIIa inhibitors (abciximab, eptifibatide, tirofiban).

Txhawm rau tshem tawm cov tsos mob ntawm kev sib quas ntus claudication, quinolinone derivative, Cilostazol, hmoov tsis tseem tau sau npe rau hauv koom pheej ntawm Belarus yog thawj qhov kev xaiv tshuaj. Cilostazol inhibits hom 3 phosphodiesterase thiab ua rau cov ntsiab lus ntau ntxiv ntawm cAMP, thim rov qab ua rau cov leeg platelet, dhau ntawm cov tshuaj aspirin, dipyridamole, ticlopidine thiab PF, inhibits qhov kev tsim ntawm txoj hlab ntshav siab thiab loj hlob ntawm cov leeg hlwb, muaj cov vasodilator thiab hypo-lipid. Cilosta-zol yog cov tshuaj nkaus xwb uas tau txo qhov tsim ntawm restenoses tom qab cog ntawm cov hlau tsis muaj hlau (CREST).

Muab qhov ua tsis tau ntawm kev siv cilostazol, kev siv tshuaj ntawm kev xaiv yog PF, kev siv qhov ntawd, raws li kev sojntsuam ntawm 23 qhov kev tshawb fawb, suav nrog kev saib xyuas 2816 tus neeg mob, nce lub sijhawm tsis taug kev mus kev thiab sijhawm tag nrho ntawm kev taug kev nrog kev sib hloov (Fontaine theem 2). Hauv kev tshawb fawb suav nrog, qhov tsis taug kev taug kev mob tau nce ntawm 33.8 mus rau 73.9%. Ntxiv rau, cilostazol muaj ntau dua li PF ua rau muaj kev phiv (mob taub hau, tso quav tsis haum, raws plab thiab palpitations). Raws li qhov kev paub qis dua ntawm cilostazol piv nrog PF, cov ntaub ntawv sib piv tsawg tsawg txog qhov ua tau zoo thiab kev tiv taus ntawm cov tshuaj no thiab cov nqi kho mob siab dua nrog cilostazol, PF yuav tsum tau nyiam nyob rau ntawm thawj theem ntawm txoj kev kho, thiab cilostazol yuav tsum yog tus kws kho mob tsis txaus PF.

Qhov kev piav qhia txog kev siv PF hauv HOZANK suav nrog lub luag haujlwm muaj pov thawj ntawm mob "mob khaub thuas", uas yog tus cwj pwm tsis yog tsuas yog los ntawm kev nce ntxiv hauv cov kev ua ntawm nws cov cim, tab sis kuj los ntawm kev ua haujlwm khoom.

endothelium ntawm procoagulant cov ntaub so ntswg qhov sib txawv, leukocyte adhesion, kev cuam tshuam ntawm endothelial nitric oxide synthesis, ua kom cov plasminogen-1 activator inhibitor synthesis. Cov txheej txheem no ua rau vasoconstriction thiab nce ntshav viscosity nrog kev pheej hmoo ntawm thrombosis. Tsis tas li, PF, raws li tau hais los saum no, muaj peev xwm txo qis kev hloov ntshav liab ntau ntxiv nrog kev nce ntxiv ntawm lawv lub peev xwm nplaum hauv cov xwm txheej ntawm tus mob hyperglycemia 30, 45.

Hauv lub siab ntawm cov kws kho mob, muaj qhov tsis pom ntawm lub neej yav dhau los uas tshaj tawm tias "kev tub sab mob syndrome", uas nthuav dav thaum tus neeg mob tau mob necompant thiab muaj kev cuam tshuam los ntawm vasodilating. Lub tswv yim tseem ceeb ntawm kev nqis tes ntawm Pf tau piav qhia los ntawm tus yam ntxwv tsis yog lumen ntawm lub nkoj, tab sis nyob rau ntawm cov ntshav ntawm cov ntshav, uas tsis tso cai rau kev txhim kho ntawm "tub sab syndrome".

Ib tug xov tooj ntawm cov kev tshawb fawb tau ua tsis tiav los qhia cov txiaj ntsig ntawm PF hauv kev kho mob ntshav qab zib neuropathy. Txawm li cas los xij, kev txhim kho hauv cutaneous ntshav txaus hauv cov hlab ntaws tau pom, nrog rau kev txhim kho hauv cov tsos mob neurological hauv cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib thiab cov ntshav qab zib mob ntshav qab zib tau hnov tom qab siv PF 10, 27. EReggap et al. qhia tias qhov tsis muaj kev kho mob ntawm PF hauv kev mob neuropathy yog cuam tshuam nrog kev soj ntsuam lub sijhawm luv luv, vim tias nws yuav siv li peb mus rau plaub lub xyoos txhawm rau txhim kho tau ntau dua.

Mob ko taw mob syndrome ntawm ntau yam xwm feem ntau yog nrog trophic kiav txhab - cov no yog lwm yam kev mob ntawm cov leeg ntshav cov hlab ntsha (HoAznk thiab varicose leeg) thiab neuropathy. Kev txhim kho ntawm kev mob qog ua raws li kev ua haujlwm ntawm apoptosis, kev tshaj tawm ntawm kev tiv thaiv, tsis muaj peev xwm ntawm kev loj hlob thiab cytokines, tsis hnov qab cov leeg mob, thiab lwm yam. Kev kho mob ntawm qhov txhab txhaws yog multicomponent thiab kev sib txawv, nyob ntawm qhov ua rau, suav nrog kev ua los txhim kho cov ntshav (kev kho mob ntawm cov teebmeem vascular thawj zaug), antibacterial txoj kev kho (yog tias qhia), txoj kev kho hauv zos siv kev them rov qab muaj peev xwm ntawm cov tshuaj. Muab kev nquag ua ke ntawm occlusal pathology ntawm cov hlab ntsha thiab cov leeg ntshav nrog kev txhim kho ntawm cov leeg txhaws tsis txaus, kev siv PF ua rau txo cov nqaij mos ntawm qhov nqaij ntawm qhov kev tshawb nrhiav, txhim kho kev kho kom zoo rau cov neeg mob uas ntev-tiv thaiv (tiv thaiv) mob rau lub cev tom qab mob rau sab hauv lub cev.

nyob rau hauv feem coob ntawm cov neeg mob. Yog li, nyob rau hauv ob lub qhov muag dig, ua rau pom tseeb, kev soj ntsuam qhov chaw-tswj hwm hauv 80 cov neeg mob uas muaj cov duab hauv chaw kho mob ntawm txoj hlab ntaws ntawm qhov mob siab ntxiv, ntxiv rau pentoxifylline rau tus qauv chav kawm ntawm kev hnav khaub ncaws thiab nyem cov ntaub qhwv yuav ua rau kom ntau zaus kho cov leeg nqaij mob.

Kev mob ntshav qab zib yog ua los ntawm kev hloov pauv ntawm cov tuab ntawm txheej hauv qab daus, kev txhim kho ntawm endothelial kev ua haujlwm tsis txaus thiab ua kom loj hlob, deformation ntawm cov ntshav liab thiab tsis zoo rau cov pa thauj (hypoxia), platelet sib sau ua ke, txo qis ntawm cov pericytes nrog kev txhim kho ntawm pob txha nqaj qaum, kab mob hauv lub raum thiab cov ntshav tawm. Txoj kev kho cov mob hlwb retinopathy, uas tau txiav tawm qhov kev xav tau rau laser photocoagulation ntawm tus retina, suav nrog kev them nyiaj rau ntshav qab zib, ntshav siab (thawj cov tshuaj yog angiotensin-hloov enzyme inhibitors), lipid-txo qis kho thiab tshuaj antiplatelet (tshuaj aspirin, uas tsis ua rau muaj kev pheej hmoo hemorrhages, ticlopidine lossis PF). Yog tias muaj cov ntaub ntawv tsis sib haum xeeb ntawm cov txiaj ntsig ntawm kev siv statins hauv retinopathy (hauv HPS txoj kev tshawb nrhiav hauv pab pawg simvastatin, qhov kev xav tau rau laser photocoagulation nce insignificantly (los ntawm 8%), hauv ASCOT-LLA qhov nce ntawm retinal thrombosis tsis muaj kev ntseeg tau (+ 3%), thiab atorvastatin tau siv rau hauv kev tshawb fawb los ntawm CARDS coj mus rau qhov kev txo qis ntawm DR cov kev hloov kho thiab qhov xav tau ntawm laser photocoagulation 6, 7, 34. Kev tiv thaiv thiab kev kho mob ntawm fenofibrate tau raug pov thawj nyob rau hauv kev tshawb fawb FIELD thiab ACCORD 14, 42.

Tau ntau xyoo, PF tau siv rau hauv kev kho mob ntshav qab zib retinopathy. Qhov sib xws ntawm qhov kev ntsuas no yog ua raws li kev txhim kho cov ntshav txaus thiab txo qis retinal hypoxia hauv cov neeg ua haujlwm zoo noj qab haus huv, hauv cov neeg mob uas muaj mob txhaws txhaws thiab tsis pom kev sai, thiab cov ntshav qab zib retinopathy 8, 13, 33.

E. Ferrari ua pov thawj rau kev txhim kho hauv rheological yam ntxwv ntawm cov ntshav thiab muaj qhov nce ntxiv hauv cov ntshav txaus hauv cov hlab ntsha ntawm retina hauv cov neeg mob uas tau txais PF piv nrog cov neeg mob hauv cov pawg placebo, thiab lub peev xwm ntawm PF los tiv thaiv neovascularization ntawm vitreous retina hauv retinal hemorrhages, suav nrog cov neeg mob nrog uas yog kuaj ntshav qab zib. Cov ntaub ntawv tshaj tawm txog kev txo qis kev loj hlob ntawm tus mob hlwb liab rau cov menyuam uas muaj ntshav qab zib hom 1. Meta-tsom xam tiam sis

Cov txiaj ntsig ntawm kev ntsuas meta-tsom xam ntawm qhov ua tau zoo ntawm pentoxifylline hauv cov kab mob ntshav qab zib: cuam tshuam rau cov proteinuria

Cov nyhuv ntawm pentoxifylline ntawm proteinuria nyob rau hauv cov kab mob ntshav qab zib: meta-tsom xam /

McCormick B. B., Sydor A., Akbari A., Fergusson D., Doucette S., Knoll G. // Am. J. Raum Dis. - 2008 .-- Vol. 52 (3). - P. 454 - 463.

Lub Cochrane database ntawm 97 cov kev tshawb fawb qhia qhov xav tau kev kawm randomized nrog kev tsim qauv tsim nyog kom paub meej cov txiaj ntsig ntawm retinopathy mob ntshav qab zib.

Ntshav qab zib nephropathy. Lub tswv yim kev siv PF hauv kev mob ntshav qab zib nephropathy:

- cov nyhuv ntawm chemokines thiab kev sib xyaw ua kom cov pa roj carbon monoxide,

- muaj kev cuam tshuam ntawm cov roj ntsha mus ncig, cov cim ntawm o - neutrophils, monocytes, lymphocytes,

- qhov cuam tshuam rau cov tsos mob ntawm "txias" o - inhibition of activated cytokines,

- kev cuam tshuam tsis suav ntawm kev ua kom tiav ntawm cov zauv sab nraud.

Qhov txiaj ntsig zoo ntawm PF rau ntawm cov ntshav hemorheological ntawm cov ntshav thaum lub sijhawm txhim kho cov ntshav qab zib nephropathy tau tshwm sim los ntawm qhov kev txo qis ntawm cov kab mob proteinuria ntau hauv hom 1 thiab 2 mob ntshav qab zib, tsis hais txog ntawm kev tswj metabolic thiab lub xeev ntawm lub raum muaj nuj nqi 10, 12, 37, 38. Cov nyhuv no kuj tseem pom hauv cov neeg mob ntshav qab zib thiab mob ntshav siab. leej twg tau txais PF raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog angiotensin-hloov enzyme inhibitors 23, 37. Nws yog ib qho tseem ceeb kom nco ntsoov tias thaum lub sijhawm meta-tsom xam ntawm cov nyhuv ntawm PF ntawm proteinuria, nws cov nyhuv hypoproteinuric yog solidified.

Nws tau qhia tias PF muab tsis tsuas yog txo qis tso zis hauv lub cev tso zis, tab sis kuj tseem txo qis ntawm TNF-a hauv ntshav plasma, qib uas nyob hauv pawg nephropathy tau nce siab. PF muaj peev xwm inhibit qhov kev txiav txim siab ntawm ^ acetyl-p-glucosaminidase (qhov cim ntawm lub raum tubular qhov txhab) hauv cov zis, hais kom muaj txiaj ntsig zoo

Cov pom tseeb tsis yog rau hauv kev tshwm sim ntawm kev mob qog glomerular, tab sis kuj rau tubulo-interstitial raum puas tsuaj rau cov neeg mob uas muaj ntshav qab zib hom 2-22-23.

Nws tau tsim los hais tias TNF-a thiab lwm yam pro-inflammatory cytokines ua si lub luag haujlwm tseem ceeb hauv kev txhim kho cov ntshav qab zib nephropathy 19, 20, 26. TNF-a yog ntau tus ua haujlwm rau cytokine zais cia feem ntau los ntawm macrophages, feem ntau adipose cov ntaub so ntswg, thiab nrog rau cov leeg- thiab paracrine teebmeem. ua tus neeg tuaj kho mob ntawm cov tshuaj insulin tsis kam thiab ib qho cim ntawm tsis muaj kev tiv thaiv kab mob, nws lub luag haujlwm hauv pathogenesis ntawm ntshav qab zib nephropathy yog qhov tsis lees paub, PF yog qhov ua kom tsis muaj zog, uas ua kom nws txoj kev kho tau zoo.

Hauv tib lub chaw, yav tom ntej, kev sib tw, tswj kev sim ntawm PREDIAN hauv kev sib koom tes ntawm 169 cov neeg mob ntshav qab zib hom 2 thiab ntshav qab zib nephropathy (CKD st. 3-4), nws tau raug pov thawj tias ntxiv ntawm PF rau angiotensin-hloov enzyme inhibitors tsub kom muaj txiaj ntsig zoo tiav (txo qis ntawm proteinuria, serum creatinine, khaws cia. GFR, cov lus txhawb txo cov roj-cytokines TNF-a, interleukin-6 thiab 10) tsawg dua.

Yog li, txawm hais tias PF tsis suav nrog hauv cov lus pom zoo tam sim no rau kev kho mob ntshav qab zib nephropathy, cov kev tshawb fawb tsis ntev los no tso cai rau peb xav txog nws ua cov tshuaj cog lus rau kev suav nrog cov kev kho mob nyuaj ntawm cov kab mob no.

Kev pom kev puas tsuaj. Txawm hais tias qhov tseeb tias kev txawj ntse poob qis rau cov neeg mob ntshav qab zib tau paub txij li xyoo 1922, thaum W.R. Mais thiab H.F Cag qhia txog koom nrog cov kab mob no nrog cov ntshav qab zib, thiab qhov tseeb no tau pom tseeb hauv ntau

cov kev tshawb fawb, hauv "qauv" teev npe mob mob ntshav qab zib, cov kab mob no tsis suav nrog. Txawm li cas los xij, kev paub tsis meej nyob rau hauv cov ntshav qab zib muaj ntau txoj hauv kev (cov vascular tiv thaiv, nrog rau kev pheej hmoo ntawm cov mob nkees thiab cov ntshav tsis zoo ntawm cov mob ntshav qab zib, amyloid deposition, glycemic fluctuations nrog kev ua haujlwm ntawm protein glycation thiab neuroglucopenia, thiab lwm yam) thiab tau sau tseg rau cov neeg muaj ntshav qab zib txog 25%. Txoj kev pheej hmoo ntawm dementia hauv ntshav qab zib yog qhov nruab nrab 1.6 npaug dua ntau dua li cov pej xeem, qhov kev pheej hmoo ntawm vascular dementia yog 2.0-2.6 nce siab dua, qhov kev pheej hmoo ntawm Alzheimer tus kab mob yog 1.5 npaug siab dua, tsis hais txog lub hnub nyoog uas muaj ntshav qab zib pib.

Kev siv PF ua rau muaj kev nce ntxiv ntawm tag nrho cov hlab ntshav khiav ntshav, cheeb tsam ntshav txaus hauv cheeb tsam ntawm cerebral ischemia thiab tsis ua rau muaj qhov tshwm sim ntawm kev nyiag. Cov kev tshawb nrhiav nyob rau xyoo tsis ntev los no tau qhia tawm cov yam ntxwv tshiab ntawm cov tshuaj uas nthuav dav cov peev txheej ntawm kev siv tshuaj kho mob hauv ntau hom kev mob hlwb ischemia, uas nyob rau hauv cov chaw kho mob ib txwm muaj feem ntau ua ke nrog lo lus "discirculatory encephalopathy" (DE) thaum tsis muaj pov thawj ntawm lub peev xwm poob qis. Nws yog qhia tau hais tias kev teem caij PF nce rau thaj tsam li ntawm 20% ntawm thaj av thiab kev mob hlwb rau cov neeg mob uas muaj kab mob cerebrovascular.

Yog li, hauv kev tshuaj xyuas txog 10 qhov kev sim kho mob rau kev soj ntsuam los ntsuas qhov ua tau zoo ntawm PF, qhov kev txo qis ntawm qhov kev nce qib ntawm lub hlwb tsis pom kev tau pom, nrog rau qhov tseem ceeb txo qis ntawm kev pheej hmoo ntawm kev tsim rov qab ischemic lub hlwb puas.

Kev tshuaj xyuas cov txheej txheem raws li cov txiaj ntsig ntawm kev txheeb xyuas ntawm 20 tus tsim-piv, randomized, placebo-tswj, ob lub qhov muag pom kev tshawb fawb tau mob siab rau kev soj ntsuam qhov ua tau zoo ntawm cov tshuaj hauv kev kho cov neeg mob vascular dementia. Qhov muaj txiaj ntsig zoo ntawm PF (1200 mg / hnub) tau tsim muaj nyob rau hauv cov neeg mob vascular dementia, tus cwj pwm los ntawm kev txhim kho hauv cov haujlwm kev txawj ntse. Ntxiv mus, qhov mob hnyav thiab qhov tseem ceeb ntawm qhov sib txawv tau nce ntxiv nrog kev siv ntau dua cov kev ntsuas rau kev kuaj mob vascular dementia.

Ntau cov kev tshawb fawb tau lees paub qhov ua tau ntawm kev siv PF thaum tsim nyog los cuam tshuam rau qhov kev xav ntawm kev tsis muaj peev xwm: ib qho kev poob qis ntawm qhov kev vam meej ntawm kev txawj ntse

kev tsis txaus siab, txhim kho lub cim xeeb, saib xyuas, tshwj xeeb tshaj yog nyob rau hauv cov neeg laus 25, 29.

Cov ntaub ntawv hais txog kev muaj peev xwm ntawm PF los txo qis kev vam meej ntawm qhov kev xav ntawm lub hlwb yog kev txaus siab los ntawm qhov pom ntawm qhov muaj peev xwm ntawm kev siv tshuaj rau kev tiv thaiv theem ob ntawm kev mob tshwm sim ntawm cov mob hlwb ischemia. Cov kev tshawb fawb tau ua nyob ntawm qhov muaj peev xwm tiv thaiv kom txhob rov ua ischemic tawm tsam.

Cov pov thawj muaj peev xwm ntawm PFs los ua kom cov leeg hlwb mononuclear hlwb, neutrophils thiab T-lymphocytes, inhibit cov synthesis ntawm cytokines tiv thaiv tuaj yeem muab cov kev tiv thaiv ntxiv hauv kev txhim kho ntawm cerebral ischemia thiab kev poob qis. Hmoov tsis zoo, nws tsis tuaj yeem nrhiav kev tshawb nrhiav txog qhov teeb meem no ua rau kev sib raug zoo ntawm cov neeg mob ntshav qab zib, tab sis cov kev siv roj ntsha dav dav rau kev txhim kho kev txawj ntse pom tias kev siv PF yuav muaj kev cuam tshuam zoo rau lub peev xwm ntawm cov neeg mob no.

Cov mob rog rog tsis muaj cawv (NAFLD). Nws yog qhov ua pov thawj tias hauv cov neeg mob uas muaj BMI ntau dhau ntawm 10-40% thiab insulin tsis kam, qhov kev pheej hmoo ntawm NAFLD tau nce. Kev mob rog pathological hauv 95-100% ntawm cov neeg mob ua ke nrog kev txhim kho ntawm hepatosis thiab hauv 20-47% ntawm steatohepatitis. Ntshav qab zib Hom 2 cuam tshuam nrog NAFLD hauv 75% ntawm cov neeg mob. Cov koom nrog ntshav qab zib nrog NAFLD muaj qhov tsis zoo nyob rau hauv chav kawm ntawm cov kab mob no. Nrog rau NAFLD thiab ntshav qab zib, qhov ntau zaus ntawm kev mob ntshav siab, mob ntshav hlab hlwb thiab peripheral vascular pathologies nce, uas ua rau muaj kev pheej hmoo hauv kev mob plawv thiab tso cai rau koj hais txog qhov muaj NAFLD ua qhov pheej hmoo ua rau mob plawv mob ntshav qab zib nyob hauv hom 2 mob ntshav qab zib, tsis hais txog glycemic tswj, tshuaj profile 40, 43. Cov kev sib raug zoo kuj raug txiav txim siab. NAFLD thiab nce kev pheej hmoo ntawm microvascular mob ntshav qab zib. Ntawm qhov tod tes, qhov kuaj pom muaj ntshav qab zib yog nrog los ntawm kev ua kom mob o, pib qhov ua tiav ntawm NAFLD rau hauv steatohepatitis (NaSg).

Nws yog qhov tseeb tias tom qab tsub zuj zuj ntawm cov rog nyob rau hauv hepatocytes thiab lub hlwb stellate los ntawm kev nce ntxiv ntawm cov roj ntsha dawb hauv lub siab, lub siab steatosis yog tsim, oxidation substrates yog tsim thiab ib qho loj ntawm cov tshuaj tiv thaiv ua rau oxidative kev nyuaj siab yog qhib, uas ua rau kev puas tsuaj rau lub siab hlwb, kev tsim cov tsis muaj cawv steatohepatitis 41, 43. Cov kev sib raug zoo ntawm NAFLD thiab visceral rog, ua rau kev txhim kho ntawm IR thiab lwm yam

metabolic ntshawv siab tshwm sim los ntawm visceral adipose cov nqaij mos ua ntau ntau ntawm cov khoom siv roj ntsha ua kom lub cev (pro-inflammatory cytokines - mob qog necrosis factor-a (TNF-a), interleukin-6, thiab lwm yam, adipocytokines - adipe-nectin, ghrelin, thiab lwm yam. ), uas txiav txim siab txog kev txhim kho ntawm tus mob metabolic syndrome thiab nws cov khoom sib txuam, txiav txim siab tiv thaiv kev kho mob thiab kho.

Nrog rau cov lus pom zoo rau txo lub cev qhov hnyav, kev tawm dag zog, kev ua tiav thiab tswj hwm tus kab mob normoglycemia, siv kev kho mob lipid-qis, thiab cov vitamins, cov hauj lwm zoo ntawm PF tau raug pov thawj. Qhov no yog vim qhov kev lees paub ntawm lub luag haujlwm ntawm pro-inflammatory cytokines, suav nrog TNF-a, nyob rau hauv lub pathogenesis ntawm NAFLD. Hauv cov neeg mob NASH, kev nrhiav pom ntau dhau los ntawm TNF-a mRNA tau tshawb pom tsis yog hauv cov ntaub so ntswg adipose, tab sis kuj nyob rau hauv hepatocytes, uas tau tshwm sim los ntawm cov ntshav ntau dua ntawm TNF-a, ua rau muaj kev txhim kho ntawm ntau cov kev cuam tshuam nrog NAFLD 41, 46. Qhov tseeb saum toj no txiav txim siab pom zoo ntawm suav nrog hauv kev kho kev kho mob ntawm NASH kev npaj ntawm TNF-a inhibitors. PF thiab angiotensin receptor blockers (losartan) tuaj yeem siv rau lub hom phiaj no.

Cov kev sim tshuaj thiab cov chaw kuaj mob tau qhia txog lub peev xwm ntawm PF los cuam tshuam kev tsim khoom ntawm TNF-a los ntawm kev hloov cov noob. Tsis ntev los no, qhov kev qhia txog meta-tsib ntawm kev tshawb fawb (147 tus neeg mob) tau tshaj tawm tias qhov kev soj ntsuam pentoxifylline rau NAFLD, qhia txog qhov kev txo qis ntawm qhov kev ua haujlwm enzyme, interleukin-6, kev txhim kho hauv daim duab histological - kev txo qis ntawm tus kabmob steatohepatitis kev ua haujlwm, kev txhim kho ntawm cov tsos mob ntawm cov leeg mob txhaws, kev txhim kho cov qauv thiab qhov mob ntawm cov leeg. Cov koob tshuaj pom zoo ntawm PF siv nyob rau hauv cov kev tshawb fawb saum toj no yog 1200-1600 mg ib hnub rau 6-12 lub hlis.

Kev hloov pauv qhia tau zoo pom zoo tso cai los tawm PF ntawm kev kho mob NAFLD. Cov txiaj ntsig tau tsim lub hauv paus rau qhov tseeb tias xyoo 2012 Lub Ntiaj Teb Gastroenterological Lub Koom Haum suav nrog pentoxifylline hauv cov tshuaj pom zoo rau kev kho mob ntawm NAFLD.

Lub plawv tsis ua hauj lwm. Ntawm cov laj thawj tseem ceeb ntawm kev txhim kho kev mob plawv mob ntshav qab zib, ntshav qab zib yuav tau ua txoj haujlwm tseem ceeb nrog rau mob ntev

obstructive pulmonary disease, hlab ntsha tawg, thiab mob plawv. Qhov kev pheej hmoo sib piv ntawm kev tuag los ntawm cov kab mob plawv yog 2.8-13.3 npaug siab dua hauv cov neeg tsis muaj ntshav qab zib - qhov no yog axiom. Cov laj thawj yog kev nrawm ntawm atherosclerosis, kev ua kom mob o, thiab kev mob ntshav qab zib tshwj xeeb, feem ntau hu ua "mob ntshav qab zib cardiomyopathy," uas thaum ntxov ntawm cov ntshav qabzib hauv lub cev tuaj yeem nrog kev ua haujlwm tsis zoo ntawm systolic thiab, feem ntau, ua haujlwm diastolic ntawm sab laug ventricle.

Cov kev cuam tshuam tseem ceeb ntawm PF tuaj yeem ua rau muaj txiaj ntsig tsis ua haujlwm hauv lub plawv, nyob rau hauv kev txhim kho ntawm cov neeg sib kho ntawm qhov mob voos xav tias yuav koom nrog, rau ntau qhov lawv tuaj yeem yog vim muaj cov tshuaj ntawm cov tshuaj ntawm TNF-a thiab lwm yam cytokines. Txo cov qib cytokines thiab cov tsos mob ntawm lub plawv tsis ua haujlwm tau qhia nyob rau hauv ntau txoj kev sim thiab kev kho mob. Kev tshawb xyuas qhov tseeb ntawm 6 qhov kev tshawb fawb txog qhov kev ntsuas sib piv ntawm cov txiaj ntsig ntawm PF (1200 mg rau ib hnub rau 6 lub hlis) ntawm kev tshwm sim ntawm lub plawv tsis ua haujlwm suav nrog cov ntaub ntawv ntawm 221 cov neeg mob uas muaj lub cev tsis meej Kuv nrhiav tsis tau dab tsi koj xav tau? Sim cov ntawv nyeem kev pabcuam xaiv.

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Txhua-Lavxias Kev Kawm Ua Haujlwm hauv Internet Tuav

Cov ntaub ntawv thiab cov ntaub ntawv coj los tso rau hauv lub xaib no yog kev tshawb fawb, kev siv, kev qhia thiab kev tshawb nrhiav hauv qhov xwm, tsuas yog npaj rau cov kws kho mob nkaus xwb, tsis yog txhawm rau txhawb cov khoom lag luam hauv khw thiab tsis tuaj yeem siv los ua cov lus qhia lossis cov lus pom zoo rau tus neeg mob rau kev siv tshuaj thiab kev kho mob yam tsis tau tham nrog koj tus kws kho mob.

Cov tshuaj noj, cov ntaub ntawv hais txog uas muaj nyob hauv lub xaib no, muaj cov lus contraindications, ua ntej siv lawv, koj yuav tsum nyeem cov lus qhia thiab sab laj tus kws tshaj lij.

Lub tswvyim ntawm Pawg Saib Xyuas tej zaum yuav tsis thooj li lub tswv yim ntawm cov kws sau ntawv thiab cov qhuab qhia. Cov thawj coj tsis muab kev lav nrog kev saib xyuas ntawm lub xaib thiab nws cov ntawv, suav nrog, tsis muaj kev txwv, nrog rau kev saib xyuas txog keeb kwm kev tshawb fawb, qhov tseeb, qhov tseeb, tiav, kev ntseeg ntawm cov ntaub ntawv tshawb fawb los ntawm cov kws qhia ntawv lossis ua raws li cov ntsiab lus nrog cov qauv thoob ntiaj teb ntawm kev soj ntsuam zoo thiab / lossis tshuaj raws ntawm cov ntaub ntawv pov thawj. Lub xaib tsis ris lub luag haujlwm rau cov lus pom zoo lossis cov tswvyim uas yuav muaj, lossis tsis muaj feem xyuam rau cov khoom siv ntawm lub xaib rau cov xwm txheej tshwj xeeb. Txhua cov ntaub ntawv tshawb fawb tau muab ua nws hom thawj, tsis muaj kev lees paub ntawm kev ua tiav lossis kev xaib sijhawm. Cov thawj coj ua txhua yam kom muab cov ntaub ntawv muaj tseeb thiab ntseeg tau, tab sis tib lub sijhawm tsis suav nrog qhov ua tau yuam kev.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, dragees thiab ib qho kev daws teeb meem npaj rau cov leeg ntshav (mob plab), txhaj tshuaj thiab tshuaj intramuscular.

Tsis hais txog ntawm daim ntawv ntawm kev tso tawm, cov tshuaj tsim nyog muaj lub ntsiab tseem ceeb ua ke - cov tshuaj pentoxifylline (hauv Latin - Pentoxyphyllinum).

Hauv qhov no, qhov ntau npaum li cas ntawm cov khoom nquag yuav txawv.

Cov ntsiav tshuaj Enteric coated muaj 100 mg ntawm pentoxifylline.

Cov tshuaj yog zwm rau pab pawg ntawm vasodilators (vasodilators).

Qhov kev daws teeb meem uas siv rau kev txhaj tshuaj muaj 20 mg ntawm cov nquag xyaw ib 1 ml. Cov tshuaj yog muag hauv ampoules ntawm 1, 2, 5 ml.

Dragees (qeeb qeeb) yog cov tshuaj ntsiav uas muaj cov ua yeeb yaj kiab liab paj yeeb. Hauv 1 lub tshuaj muaj 400 mg ntawm cov tshuaj muaj zog.

Mechanism ntawm kev ua

Cov tshuaj yog zwm rau pab pawg ntawm vasodilators (vasodilators).

Cov nyhuv pharmacological ntawm cov tshuaj yog tsom rau normalizing ntshav ncig thiab txhim kho cov ntshav.

Cov tshuaj no muaj cov kev cuam tshuam hauv qab ntawm tus neeg mob lub cev:

txo cov ntshav viscosity, txo qhov ntxim nyiam ntawm cov ntshav txhaws,
dilates cov hlab ntsha (mob pesnrab), tshem tawm cov teeb meem nrog cov ntshav microcirculation,
txhawb cov nqaij ua pa oxygen saturation, tiv thaiv kev txhim kho hypoxia (vim yog nthuav dav ntawm cov hlab ntsws thiab hlab plawv),
ua rau kom nrov dua qub cov diaphragm, mob nqaij ntshiv,
muaj txiaj ntsig zoo rau cov kev ua ntawm lub paj hlwb,
Pab tshem tawm qhov cramps thiab qhov mob hauv plab plab hlaub ua rau muaj kev ntshaus siab hauv nqua.

Cov tshuaj txo cov ntshav viscosity, txo qhov ntxim nyiam ntawm cov ntshav txhaws.

Dab tsi pab

Cov tshuaj yaj yeeb yog siv nyob rau hauv kev kho cov nram qab no pathologies:

ua txhaum ntawm cov hlab ntsha tso rau hauv tes thiab taw (Raynaud's syndrome),
cov ntaub so ntswg los ntawm kev ua tsis taus ntshav microcirculation hauv cov hlab ntsha thiab leeg ntshav (cov tawv nqaij ua kom tawv nqaij, mob tom qab mob ntsws, mob txha caj qaum),
pom thiab tsis hnov lus cuam tshuam txog cov kev ua haujlwm tsis txaus siab,
cerebral ischemia,
Buerger's disease (thromboangiitis obliterans),
impotence tshwm sim los ntawm cov ntshav txaus los mus rau lub tsev me nyuam yug menyuam,
mob hlwb atherosclerosis,
leeg ntshav siab
angiopathy nyob rau hauv cov neeg mob ntshav qab zib mellitus,
mob plawv plawv
vegetovascular dystonia,
encephalopathy ntawm ntau yam etiologies.

Cov tshuaj yog siv hauv kev kho mob ntawm Raynaud's syndrome.
Cov tshuaj no ua haujlwm rau cerebral ischemia.
Pentoxifylline yog siv rau impotence tshwm sim los ntawm cov ntshav tsis txaus rau cov khoom yug me nyuam.
Cov twj yog siv los kho ntshav siab.
Pentoxifylline yog siv rau hauv kev kho mob ntawm angiopathy hauv cov neeg mob ntshav qab zib mellitus.
Pentoxifylline yog tshuaj rau lub cev nqaij hlav leeg.

Cov cuab yeej tseem siv rau hauv kev kho mob ntawm osteochondrosis ua tus pabcuam vasodilator.

Cov Yuav Tsum Muaj

Daim ntawv ntawm contraindications rau kev siv ntawm cov tshuaj muaj xws li:

Kab mob porphyrin
mob myocardial infarction,
ntshav ntswg hauv siab,
los ntshav heev.

Txoj kev daws teeb meem tsis yog siv rau atherosclerosis ntawm cov hlab ntsha ntawm lub paj hlwb thiab lub plawv thiab mob ntshav siab ntau.

Kev siv cov Pentoxifylline tsis suav nrog cov neeg mob uas lub cev tsis tshua haum rau cov tshuaj, cov neeg tsis muaj nyob hauv nws cov tshuaj, lossis lwm yam tshuaj los ntawm cov pab pawg xanthine.

Nrog atherosclerosis ntawm cov hlab ntsha ntawm lub hlwb thiab lub plawv, cov tshuaj tsis siv tshuaj yog qhov kev daws teeb meem.

Yuav noj li cas

Cov tshuaj, muaj nyob rau hauv daim ntawv ntawm dragees thiab ntsiav tshuaj, yog npaj rau kev tswj hwm qhov ncauj. Siv cov tshuaj tom qab noj mov. Koj tsis tuaj yeem zom cov tsiav tshuaj. Lawv yuav tsum tau ntxuav nrog lub me me ntawm dej.

Tus kws kho mob txiav txim siab qhov ntau npaum li cas ntawm cov tshuaj ib leeg zuj zus rau txhua tus neeg mob, coj mus rau hauv tus account lub yam ntxwv ntawm nws lub cev thiab raws li cov ntaub ntawv los ntawm cov chaw kuaj mob ntawm tus kab mob. Cov qauv tshuaj muab yog 600 mg rau ib hnub (200 mg 3 zaug ib hnub). Tom qab 1-2 lub lis piam, thaum cov tsos mob ntawm tus mob tsis zoo zuj zus, qhov koob tshuaj txhua hnub raug txo mus rau 300 mg (100 mg 3 zaug hauv ib hnub). Tsis txhob noj ntau dua li cov tshuaj pom zoo hauv ib hnub (1200 mg).

Lub sijhawm kho nrog pentoxifylline hauv ntsiav tshuaj yog 4-12 lub lis piam.

Txoj kev daws teeb meem tuaj yeem muab cov tshuaj intramuscularly, tso leeg thiab nrog leeg. Tsuas tshuaj yog txiav txim siab ntawm tus kheej, coj mus rau hauv tus account qhov hnyav ntawm cov leeg tsis zoo. Cov lus qhia rau kev siv yeeb tshuaj hais tias koj yuav tsum siv txoj kev daws teeb meem raws li hauv qab no:

Hauv daim ntawv ntawm cov neeg poob qis - 0.1 g ntawm cov tshuaj sib xyaw nrog 250-500 ml ntawm kua ntsev lossis 5% kua nplaum. Nws yog ib qho tsim nyog yuav tsum qhia cov tshuaj qeeb qeeb, tsis pub dhau 1.5-3 teev.
Kev hno tshuaj (tso ntshav) - thaum pib theem ntawm kev kho mob, 0.1 g ntawm cov tshuaj yog kws kho (diluted nyob rau hauv 20-50 ml ntawm sodium chloride), tom qab ntawd cov koob tshuaj tau nce mus txog 0.2-0.3 g (sib xyaw nrog 30-50 ml ntawm cov tshuaj lom). Nws yog qhov tsim nyog yuav tsum tau nkag mus rau cov tshuaj maj mam (0,1 g hauv 10 feeb).
Intramuscularly, cov tshuaj yog tau muab tshuaj hauv qhov ntau npaum ntawm 200-300 mg 2-3 zaug hauv ib hnub.

Cov qauv tshuaj muab yog 600 mg rau ib hnub (200 mg 3 zaug ib hnub).

Kev siv ntawm txoj kev daws tuaj yeem ua ke nrog kev tswj hwm ntawm qhov ncauj ntawm cov ntsiav tshuaj daim ntawv ntawm cov tshuaj.

Nrog ntshav qab zib

Pentoxifylline kev npaj ua tiav raug pom zoo rau kev siv rau kev kho mob ntawm thiav txhab, mob caj pas, mob qog thiab nrog kev hloov pauv ntawm cov yeeb yam hauv cov neeg mob ntshav qab zib. Txawm li cas los xij, koj tuaj yeem noj cov tshuaj tsuas yog raws li kws kho mob tau hais, tus kws kho mob qhov tshuaj noj ib lub zuj zus thiab paub tseeb tias yuav tau kho nws yog tias tus neeg mob siv tshuaj hypoglycemic. Kev noj tshuaj rau tus kheej nrog pentoxifylline hauv qhov xwm txheej no tsis tuaj yeem lees paub, vim tias kev xaiv tshuaj tsis raug xaiv tsis zoo tuaj yeem ua rau qhov kev txhim kho tsis haum (suav nrog hypoglycemic coma).

Pentoxifylline hauv kev tawm dag zog

Kev siv ntawm Pentoxifylline tuaj yeem siv tsis tau tsuas yog siv rau kev kho mob ntawm cov kab mob, tabsis tseem muaj kev ua kis las, vim tias cov tshuaj muaj peev xwm nce kev ua haujlwm tau zoo, ntxiv kev ua siab ntev, nrawm rau kev ua tiav qhov txiaj ntsig xav tau vim muaj txiaj ntsig zoo rau lub cev.

Pentoxifylline muaj peev xwm nce kev ua tau zoo ntawm kev qhia, ua rau muaj siab ntev, ua kom nrawm ua tiav cov txiaj ntsig yam xav tau.

Cov kws ncaws pob thiab cov kws tawm dag zog tau qhia kom noj cov tshuaj no raws li nram no:

Nws yog ib qho tsim nyog yuav tsum tau pib nrog kev noj me me - 200 mg 2 zaug ib hnub. Haus tshuaj tom qab noj mov.
Thaum tsis muaj kev mob tshwm sim thiab kev tiv thaiv zoo ntawm cov tshuaj, koj tuaj yeem nce cov tshuaj rau txhua hnub rau 1200 mg (400 mg 3 zaug hauv ib hnub).
Yuav kom ua tiav qhov tshwm sim zoo tshaj plaws, nws raug nquahu kom noj cov tshuaj 30 feeb ua ntej kev ua haujlwm thiab ob peb teev tom qab ua tiav.
Lub sijhawm ntawm kev siv tshuaj yog 3-4 lub lim tiam. Tom qab kawm tiav, koj yuav tsum coj mus so li 2-3 lub hlis.

Lub plab zom mov

Cov tshuaj muaj peev xwm ua rau lub siab ua rau lub siab, nrog cov teeb meem hauv lub nrawm ntawm bile masses, exacerbation ntawm tus kab mob inflammatory ntawm lub plab, ua rau mob plab hnyuv kom tsis muaj zog, tsis qab los noj mov, thiab lub siab nyob hauv qhov ncauj tawm ntawm lub qhov ncauj. Tsawg tsawg zaus, los ntshav hauv txoj hnyuv cov cai.

Lub cuab yeej tuaj yeem ua rau kis mob ntawm daim siab, nrog rau kev nyuaj hauv cov tawm ntawm cov kab mob bile.

Nruab nrab hauv lub paj hlwb

Caj ncees, mob taub hau, kiv taub hau, thiab pw tsaug zog tsis zoo yuav tshwm sim.

Tus neeg mob noj tshuaj feem ntau yuav muaj kev txob taus thiab txom nyem los ntawm ntau kev ntxhov siab.

Thaum siv cov tshuaj, cov tawv nqaij ua xua (khaus, urticaria) thiab khaus anaphylactic yog ua tau.

Lwm yam tshuaj tiv thaiv

Tej zaum yuav muaj qhov tsis zoo rau qhov xwm txheej ntawm plaub hau, rau tes, o, tawv nqaij liab ("ntshav" mus rau lub ntsej muag thiab lub hauv siab).

Thaum siv cov tshuaj, cov tawv nqaij ua xua thiab anaphylactic kev poob siab yuav tshwm sim.

Kev ua txhaum ntawm kev saib pom thiab kev txhim kho ntawm scotomas ntawm lub qhov muag tsis suav nrog.

Cov lus qhia tshwj xeeb

Pentoxifylline kev kho mob yog ua tiav nrog kev saib xyuas zoo hauv cov neeg uas mob peptic rwj ntawm lub plab thiab duodenum, pathologies ntawm lub raum thiab mob siab, lub plawv tsis ua haujlwm, feem ntau muaj ntshav siab. Rau cov pawg no ntawm cov neeg mob, yuav tsum tau txhaj tshuaj ntau dua thiab tswj hwm kev kho mob thoob plaws hauv chav kawm ntawm kev kho mob yog tsim nyog.

Cawv tau zoo

Cov kws kho mob xav pom zoo kom cov neeg mob noj tshuaj raws Pentoxifylline cais tsis pub haus cawv ua ntej kev kho mob.

Nws raug nquahu kom tsis suav cov cawv haus ua ntej thaum xaus ntawm kev kho mob nrog Pentoxifylline.

Kev haus dej cawv ethyl tuaj yeem khi mus rau cov lwg me me ntawm cov tshuaj yeeb tshuaj, ua rau lawv tsis zoo los yog txhim kho kev ua haujlwm ntawm cov nquag, uas tuaj yeem ua rau txo qis ntawm cov tshuaj lossis ua rau muaj kev cuam tshuam.

Cuam tshuam rau lub peev xwm los tswj cov tshuab

Cov tshuaj tsis cuam tshuam ncaj qha rau lub peev xwm los tswj cov txheej txheem nyuaj, nrog rau cov tsheb, txawm li cas los xij, yog tias muaj qee qhov kev mob tshwm sim (kiv taub hau, pw tsaug zog, thiab lwm yam) tshwm sim, tus neeg mob lub siab mloog yuav tuaj. Qhov no tuaj yeem txo qis zog ntawm kev tsav tsheb thiab lwm lub tsheb.

Dab tsi yog xaj dab tsi rau me nyuam yaus

Qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj rau menyuam yaus tsis tau kawm, yog li ntawd, cov tuam txhab tsim ntawm Pentoxifylline tsis pom zoo kom muab cov tshuaj no rau cov neeg mob hnub nyoog qis dua 18 xyoo.

Pentoxifylline tsis pom zoo kom muab cov tshuaj no rau cov neeg mob hnub nyoog qis dua 18 xyoo.

Txawm li cas los xij, hauv kev coj ua, yog tias xav tau tiag tiag, cov kws kho mob tuaj yeem sau tshuaj rau cov menyuam no uas muaj 12 xyoos. Feem ntau qhov no yog vim muaj kev cuam tshuam loj heev thiab kev ua tsis tau zoo ntawm kev siv lwm txoj kev kho.

Noj ntau dhau

Nrog lub sijhawm ntev ntawm kev siv lub siab ntawm cov tshuaj, cov tsos mob li nram no ntawm kev siv ntau tshaj yuav tshwm sim:

xeev siab, ntuav ntawm "thaj chaw kas fes" (qhia txog kev txhim kho lub plab zom mov),
kiv taub hau
tsis muaj zog
cramps.

Hauv kev muaj mob hnyav ntawm kev siv tshuaj ntau dhau, tsaus muag, ua pa nyuaj, anaphylaxis pom.

Nyob rau hauv cov mob hnyav dua, tsaus muag, ua pa nyuaj, anaphylaxis muaj cai.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj yuav txhim khu cov nyhuv ntawm cov tshuaj hauv qab no:

tshuaj thaiv tsev
thrombolytics
ntshav siab txo cov tshuaj
tshuaj tua kab mob
cov tshuaj insulin thiab cov tshuaj hypoglycemic,
valproic acid-based npaj.

Kev siv tib lub sijhawm ntawm Pentoxifylline thiab cov tshuaj muaj cimetidine nce qhov kev pheej hmoo ntawm kev mob tshwm sim. Kev npaj raws ketorolac thiab Mexico tsis sib xws nrog Pentoxifylline, vim tias thaum sib cuam tshuam nrog kev noj tshuaj, lawv nce txoj hauv kev tsim kev los ntshav hauv sab hauv.

Koj tsuas tuaj yeem yuav cov khoom lag luam nkaus xwb yog tias koj muaj cov tshuaj uas tsim nyog sau los ntawm koj tus kws kho mob.

Nws tsis pom zoo kom sib xyaw ua ke ntawm kev siv tshuaj nrog kev siv lwm tus xanthines, vim tias qhov no tuaj yeem ua rau muaj kev ntxhov siab ntau dhau.

Hauv kev kho cov kab mob los ntawm kev mob ntshav siab, ntshav Pentoxifylline analogues yog siv:

Pob tawb
Trental
Pentoxifylline-NAS,
Piracetam
Pentilin
Mexidol
Ntshav
Latren
nicotinic acid.

Txhawm rau txiav txim siab seb yuav siv cov tshuaj twg zoo tshaj rau qee qhov kev mob ntshav tsis txaus, koj yuav tsum sab laj nrog koj tus kws kho mob.

KHIB NYHIAB EXPANSION KHOOM. Kuv puas yuav tsum tau zwm rau cov hlab ntshav nrog tshuaj. Pentoxifylline

Pentoxifylline Kev Tshawb Xyuas

Feem ntau cov kws kho mob thiab cov neeg mob teb tau zoo rau kev siv Pentoxifylline.

E. G. Polyakov, neurosurgeon, Krasnoyarsk

Cov tshuaj muaj qhov qhia tau zoo nyob hauv ntau qhov kev cuam tshuam ntawm nruab nrab thiab ntu ncig. Cov cuab yeej yog qhov ua tau zoo thiab tus nqi qis, yog li nws tau muaj rau txhua pawg ntawm tus neeg mob. Qhov tsis zoo ntawm cov tshuaj muaj xws li cov nyhuv tsis muaj zog hauv angiopathies.

Lily, 31 xyoo, Astrakhan

Kuv tau raug kev txom nyem los ntawm kev tawm tsam ntawm cov neeg mob nqaij hlav (dyovascular dystonia), uas tau cuam tshuam zoo rau kuv qhov tseem ceeb. Tam sim no kuv tau kho nrog Pentoxifylline. Nrog kev tawm tsam tom ntej, Kuv pib noj cov tshuaj no hauv ib chav kawm (hauv 10 hnub). Kev nyem tshwm sim hauv thawj hnub ntawm kev kho mob, thiab tom qab 10 hnub tag nrho cov tsos mob ploj mus kom tas. Tshwj xeeb mloog yuav tsum tau them rau tus nqi ntawm cov tshuaj: nws yog li ntawd tias tsawg kawg thaum xub thawj nws tseem ceeb. Tab sis qhov zoo tshaj ntawm Lavxias Pentoxifylline tsis muaj qhov phem dua li ntawm cov yeeb yaj kiab txawv teb chaws, uas raug nqi 2, lossis txawm tias 3 zaug kim dua.

Igor, 29 xyoo, Volgograd

Txhawm rau txhim kho ntshav microcirculation hauv lub raum, vasodilators yuav tsum tau ua. Curantil tau raug sau tseg yav dhau los, tab sis nws lub taub hau ua rau mob heev, yog li kuv yuav tsum hloov mus rau Trental. Cov no yog cov tshuaj zoo, tab sis kim heev, yog li kuv txiav txim siab hloov lawv nrog Lavxias-ua Pentoxifylline. Kuv tsis pom qhov txawv (tshwj tsis yog tus nqi). Lawv kuj coj, lawv tsis ua rau muaj kev phiv tshuaj, lawv ua lawv txoj haujlwm zoo kawg nkaus.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov ntsiav tshuaj ntawm 100 thiab 400 mg, coated nrog ib cov xim lo xim. Cov pob muaj 20 thiab 60 daim.

100 thiab 400 mg ntsiav tshuaj. Cov pob muaj 20 thiab 60 daim.

Enteric coated 400 thiab 600 mg kho mob-tso cov ntsiav tshuaj nrog cov kab sib faib - pob muaj 50 daim.

Ampoule nrog kev daws rau kev txhaj tshuaj. Hauv 1 ml ntawm kev daws muaj:

pentoxifylline - 20 mg,
sodium tshuaj dawb - 90 mg,
dej - txog li 1 ml.

Muaj nyob rau hauv ampoules ntawm 5 ml. Cov pob muaj 5 ampoules.

Puas yog nws tsis zoo rau noj pentoxifylline thaum cev xeeb tub?

Nws paub tias ib qho tshuaj twg raug tso cai kom noj thaum lub sijhawm

tsuas yog tias nws dhau qhov tshwj xeeb kev nyab xeeb rau leej niam thiab tus me nyuam hauv plab. Pentoxifylline tsis dhau qhov kev tswj hwm no, yog li ntawd, txhua cov lus qhia tau qhia tias nws yog contraindicated hauv kev xeeb menyuam.

Puas muaj cov cim qhia rau pentoxifylline thaum cev xeeb tub?

Raws li koj paub, hauv thawj lub lis piam ntawm cev xeeb tub, txhua yam tshuaj yog contraindicated. Cov tshuaj uas tsis tau tshawb nrhiav kev nyab xeeb yuav tsum tau siv tshwj xeeb tom qab nees nkaum lub lis piam tom qab cev xeeb tub, tsim nyog nyob hauv kev saib xyuas ntawm kws kho mob cev xeeb tub.

Tab sis tej zaum yuav muaj tus me nyuam hauv plab uas nws tsim nyog yuav tsum siv cov tshuaj no. Lawv raug siv los txhim kho cov khoom ntawm lub qe tso nrog ntshav thiab oxygen.

Cov tshuaj muaj dab tsi tshwm sim thaum cev xeeb tub?

Pentoxifylline cuam tshuam cov microcirculation hauv cov ntaub so ntswg, nthuav cov hlab ntsha me, txo cov ntshav viscosity thiab txhim kho nws cov kev npliag hauv cov hlab ntshav. Cov ntshav pib ya mus thoob plaws, thiaj li txhim kho cov pa oxygen mus rau qhov tso tseg. Cov tshwm sim no yog qhov tseem ceeb heev rau kev loj hlob ntawm tus me nyuam hauv plab.

Tsis ntseeg, cov kws kho mob hnyav txhua qhov zoo thiab qhov tsis zoo ntawm kev muab tshuaj rau thaum cev xeeb tub. Nws cov khoom tau txais txiaj ntsig feem ntau yog siab dua qhov kev pheej hmoo ntawm kev cuam tshuam tsis zoo.

Kev tshuaj xyuas cov poj niam cev xeeb tub noj Pentoxifylline feem ntau yog qhov zoo.

Raws li cov lus qhia, Pentoxifylline tsis tau teev tseg thaum cev xeeb tub / lactation.

Txij li thaum tsis muaj kev paub txog kev siv cov tshuaj ntawm cov poj niam cev xeeb tub, thiab kev nyab xeeb ntawm cov tshuaj ntawm txoj kev loj hlob ntawm tus me nyuam hauv plab tsis tau muaj pov thawj, Pentoxifylline ntsiav tshuaj tsis yog kws kho rau cov poj niam uas xav tias yuav yug menyuam.

Cov ntaub ntawv hais txog kev muaj peev xwm ua rau tshem tawm ib cov tshuaj nrog niam mis tsis muab, yog li, yog tias tsim nyog kho, tus poj niam yuav tsum txiav txim siab thaum ua tiav lactation thiaj li tsis ua rau tus me nyuam tsis muaj kev pheej hmoo.

Yeeb tshuaj sib cuam tshuam

Txhim kho cov nyhuv ntawm antihypertensive thiab antidiabetic tshuaj (qhov koob tshuaj yuav tsum tau txo). Thaum ua ke nrog sympatholytics, ganglioblockers, vasodilators, txo qis ntshav siab yog ua tau, nrog ketolorac, meloxicam - nce prothrombin lub sijhawm nrog kev pheej hmoo los ntshav, nrog heparin, fibrinolytic tshuaj thiab tsis ncaj rau anticoagulants - cov tshuaj tiv thaiv anticoagulant ntau dua.

Cimetidine tsub kom lub siab ntxiv

Pentoxifylline

nyob rau hauv cov ntshav nrog nce kev ntxim siab ntawm phiv.

Pentoxifylline, raws li txoj cai, txhim kho cov nyhuv ntawm cov tshuaj uas txo cov ntshav siab, nrog rau cov tshuaj uas npaj rau kev kho

Kev siv ua ke ntawm Pentoxifylline nrog qee cov tshuaj / tshuaj tuaj yeem ua rau kom muaj kev loj hlob ntawm cov teebmeem hauv qab no:

Cimetidine: tsub kom lub siab ntawm pentoxifylline hauv ntshav ntshav thiab, vim li ntawd, qhov tshwm sim muaj qhov tshwm sim tsis zoo,
Valproic acid, heparin, theophylline, tshuaj fibrinolytic, antihypertensive thiab hypoglycemic agents (insulin, hypoglycemic agents), tshuaj uas cuam tshuam rau cov ntshav coagulation system (anticoagulants, thrombolytics), tshuaj tua kab mob (nrog rau cephalosporins, nce ntxiv):
Lwm cov xanthines: kev ntxhov siab ntxhov siab ntau dhau los.

Kev Ntsuam Xyuas Daim Ntawv Thov

Cerebrovascular pathology, tshwj xeeb hauv kev mob ntshav ntawm txoj hlab ntshav ntawm lub cev, mob tom qab myocardial infarction, mob ntshav qab zib nephroangiopathy thiab lwm yam mob ntshav qab zib, mob tsis zoo ntawm lub plawv (Raynaud's disease, endarteritis, thiab lwm yam), vascular pathology ntawm lub qhov muag (mob thiab mob ntshav tsis ua haujlwm ntawm lub qhov muag tsis pom kev thiab choroid).

Lub luag haujlwm tsis hnov lus ntawm cov keeb kwm vascular.

Muab tso rau sab hauv ntawm txoj leeg ntshav thiab sab hauv. Sab hauv, noj, pib nrog 0.2 g (2 ntsiav tshuaj) 3 zaug hauv ib hnub tom qab noj mov, yam tsis tas yuav zom. Tom qab qhov pib ntawm kev ua kom zoo li qub (feem ntau yog tom qab 1-2 lub lis piam), lub koob tshuaj yog txo mus rau 0.1 g (1 ntsiav tshuaj) 3 zaug hauv ib hnub. Lub chav kawm ntawm kev kho mob yog 2-3 lub lis piam. thiab ntau dua.

Yog tias tsim nyog (mob tsis sib haum ntawm ntu lossis nqaj mob hlwb / mob hlab ntsha / / leeg hlab ntshav /) raug tso ntshav lossis tso ntshav los ntshav. 0.1 g (1 ampoule) yog muab tshuaj rau hauv 250-500 ml ntawm cov tshuaj isotonic sodium chloride tov lossis hauv 5% cov piam thaj hauv 90-180 feeb.

Qhov koob tshuaj txhua hnub tuaj yeem raug txuas ntxiv nce mus txog 0.2-0.3 g .Txhais ntxiv, thawj 0.1 g ntawm cov tshuaj tau muab rau hauv 20-50 ml ntawm ib qho tshuaj sodium isotonic sodium chloride, thiab hnub tom qab, 0.2-0.3 g txhua (hauv 30-50 ml ntawm cov tshuaj lom). Ntaus ntawm tus nqi ntawm 0.1 g (5 ml ntawm ib 2% daws ntawm cov tshuaj) rau 10 feeb

Dosage regimen and route of administration: ntsiav tshuaj, txhaj tshuaj, tee

Cov tshuaj no noj ntawm qhov ncauj thiab niam txiv, nyob ntawm qhov mob loj heev.

Thaum noj ntawm qhov ncauj, ntsiav tshuaj nrog qhov ntau npaum ntawm 100 mg siv. Lawv pib noj, feem ntau, nrog ib koob tshuaj 200 mg - 2 ntsiav tshuaj 3 zaug hauv ib hnub tom qab noj mov. Tom qab ntawd, thaum kho cov nyhuv yog ua tiav, cov koob tshuaj raug txo kom tsawg, thiab cov ntsiav tshuaj txuas ntxiv tau noj peb zaug ib hnub. Cov chav kawm ntawm kev kho mob nrog kev npaj ntsiav tshuaj kav ib hlis.

Hauv kev mob hnyav thiab mob hnyav ntawm cov plab hnyuv siab raum, pentoxifylline yog tshuaj hauv ampoules. Muaj ob txoj hauv kev ntawm kev tswj hwm tshuaj yaj yeeb: tshuaj cev leeg thiab leeg ntshav.

Tus neeg sawv cev yog tswj cov dej khov rau hauv daim ntawv ntawm cov neeg ua poob. Ib qho ampoule yog siv rau ib qho 250 ml ntawm sodium chloride tov, los yog kua qab zib. Qhov tshuaj no tau muab tshaj li ib thiab ib nrab rau ob teev, maj mam.

Qhov koob tshuaj txhua hnub tuaj yeem raug nce nrog zoo siab txog 0.2-0.3 g (raws li kev qhia).

Ua haujlwm hauv thaj tsam, lawv pib tswj los ntawm ib koob ntawm 0.1 g ntawm yeeb tshuaj ib 50 ml ntawm sodium tov tshuaj, tom qab ntawd 0.2-0.3 g txhua.

Qhov kev daws tau txhaj tshuaj maj mam dhau 10 feeb. Qhov kev kawm siv 10 infusions.

Nrog mob vascular

Pentoxifylline (Trental) tau ua tiav yog siv rau hauv kev kho mob ntawm kev mob ncua ntev

Cerebrovascular tus kab mob yog qhov ua rau ploj tuag hauv tib neeg, tshwj xeeb tshaj yog cov neeg laus. Feem ntau tsis muaj tsuas yog mob hnyav ntawm kev mob hlwb, tab sis kuj yog cov uas muaj mob ntev.

Hauv Lavxias, kev ua xiam oob qhab cerebrovascular raug cais raws li DE - discirculatory encephalopathies. Tus kab mob no tau hais tawm ua ntu zus los ntawm lub hlwb ua haujlwm, uas tshwm sim los ntawm lub cev tsis ua haujlwm.

Cov tsos mob tseem ceeb ntawm tus kab mob no yog mob hlwb, lub siab ntsws thiab lub cim kev paub, thaum muaj lub cim xeeb poob qis, ua kom qeeb ntawm kev xav, pw tsis taus thiab lwm yam kev cuam tshuam.

Txhawm rau kho cov kab mob no, cov kws kho mob tau sau ntawv rau Pentoxifylline, lossis nws cov duab analogues. Cov tshuaj no txhim kho microcirculation, txo platelet kev sib sau, thiab ua rau kom ntshav khiav haujlwm.

Raws li cov kws tshawb fawb, kev siv Pentoxifylline rau peb mus rau plaub lub lis piam txhim kho cov ntshav hlwb thiaj li muaj 17%. Txawm li cas los xij, kev siv cov tshuaj tsis ua rau mob intracerebral tub sab mob syndrome.

Pentoxifylline yog dav siv los kho mob vascular. Cov no suav nrog kev sib quas ntus tsis tu ncua hauv cov neeg mob uas muaj kev puas tsuaj rau cov hlab ntsha ntawm cov qis qis. Ib qho tshuaj zoo nyob hauv kev kho mob ntawm trophic mob rau sab qis qis.

Hauv kev kho mob ntawm trophic mob txhab

Tus kab mob no ua rau muaj kev txom nyem loj rau cov neeg mob -

kho mob qeeb, muaj kev nyiam cuam tshuam.

Kev siv Pentoxifylline yog qhov tsim nyog hauv kev kho mob ntawm qhov mob txhab. Cov tshuaj, txhim kho ntshav ncig hauv thaj chaw muaj kev cuam tshuam, txhawb kev kho kom sai ntawm cov tawv nqaij tiv thaiv tsis tau zoo tom qab ntawm lwm txoj kev.

Nrog kab mob siab

Pentoxifylline txo qhov tshwm sim ntawm cov teeb meem

Xyoo tsis ntev los no, cov chaw tshiab tau tshawb nrhiav hauv kev siv Pentoxifylline. Tam sim no, cov txiaj ntsig zoo ntawm kev kho mob nrog cov tshuaj no rau ib tus kab mob xws li mob nyhav cawv ntau tau muaj pov thawj.

Kev txheeb xyuas txog kev siv Pentoxifylline feem ntau yog qhov zoo. Cov tshuaj yog qhov ua haujlwm zoo rau vascular txhab ntawm ntau yam kabmob thiab cov kab ke. Feem ntau ib tus neeg muaj mob vascular raug yuam kom noj tshuaj ob zaug ib xyoos - tsuas yog tom qab ntawd koj tuaj yeem tswj hwm koj tus mob thiab cov chav kawm ntawm tus kab mob.

Ntau qhov kev txheeb xyuas tau nthuav tawm txog kev siv Pentoxifylline hauv cov txiv neej raug mob los ntawm obliterating endarteritis nrog cov kev tshwm sim ntawm kev sib cav tsis sib haum. Pentoxifylline yog lawv qhov tshuaj thib 1, vim tias tus kab mob nyhav rau kev vam meej.

Dab tsi yog cov ntsiav tshuaj thiab daws tau los ntawm? Cov tshuaj yog tawm rau kev ua haujlwm tsis xws luag ntawm cov ntshav tawm, nqaij ntshiv trophism, Raynaud's disease, obliterating endarteritis, post-thrombotic syndrome, frostbite, gangrene, trophic mob rau sab ceg qis, varicose leeg, cerebral atherosclerosis, viral neuroinfection, thiab dyscirculatory encephalopathy.

Kuj cov cim qhia txog kev siv Pentoxifylline yog: myocardial infarction, mob plawv, mob ntsws bronchial, mob siab rau hauv cov ntshav xa mus rau retina, choroid, otosclerosis, impotence ntawm vascular keeb kwm.

Pentoxifylline daws, cov lus qhia rau kev siv

Cov tshuaj hauv ampoules raug muab tshuaj intramuscularly thiab intraarterially nyob rau hauv tus neeg mob txoj hauj lwm supine.

Nrog rau cov kab mob pathology ntawm lub raum, qhov ntau npaum yog txo rau 50-70 feem pua ntawm cov txheej txheem tshuaj.

Tso tshuaj maj mam tswj, xam raws li cov txheej txheem: 50 mg rau txhua 10 ml ntawm sodium chloride 0.9%, txhaj rau 10 feeb, thiab tom qab ntawd hloov mus rau ib qho chaw xa mus: 100 mg diluted hauv 250-500 ml ntawm sodium chloride 0.9% lossis dextrose daws 5 %

Ua haujlwm hauv: 100 mg yog diluted hauv 20-50 ml ntawm sodium chloride.

Intramuscularly muab txoj kev xav tob tob rau peb zaug hauv ib hnub, 100-200 mg.

Pentoxifylline ntsiav tshuaj, cov lus qhia rau kev siv

Ntxiv nrog rau kev tswj hwm hauv tsoomfwv, nws raug tso cai kom noj cov tshuaj hauv tom qab noj mov ob zaug ib hnub, ntawm 800-1200 mg. Thawj qhov tshuaj thawj zaug hauv cov ntsiav tshuaj yog 600 mg, maj mam cov tshuaj txo mus rau 300 mg ib hnub twg. Lub sijhawm ntev ntawm cov tshuaj siv ob zaug ib hnub.

Pentoxifylline angioprotector yog qhia rau siv nyob rau hauv txoj kev kho mob ntawm cov kab mob ntawm cov hlab plawv system.

Cov tshuaj yog tawm rau kev kho mob ntawm cov hlab ntsha hauv lub cev, nrog cov leeg tsis muaj peev xwm.

Pentoxifylline, nqus mus rau hauv cov ntshav, hauv zos ua rau cov hlab ntsha cuam tshuam, tshem tawm atherosclerotic tso, ntxiv dag zog rau cov phab ntsa venous.

Kev qhia rau kev siv tshuaj:

ua txhaum ntawm peripheral ncig (endarteritis, angiopathy),
atherosclerotic los yog discirculatory angiopathies,
cerebrovascular kev huam yuaj,
post-ischemic, post-stroke mob.

Kev daws rau Txoj kev lis ntshav, kev daws teeb meem rau kev tswj hwm ntawm txoj kev ua tiav ntawm txoj kev khiav lag luam thiab kev hnyav

Kev tswj hwm hauv lub cev: tus nqi - 10 mg ib feeb, thawj koob - 100 mg ntawm cov tshuaj (hauv 0.9% sodium chloride tov nrog cov ntim ntawm 20-50 ml), yav tom ntej, cov koob tshuaj tau nce ntxiv rau 200-300 mg (hauv 0.9% sodium chloride tov ntim 30-50 ml).

Pentoxifylline yog muab rau cov leeg tshuaj maj mam maj mam dhau 90-180 feeb:

Kev daws rau Txoj kev lis ntshav: koob tshuaj - 50-100 mg, yog tias tsim nyog - 200 mg (siab tshaj plaws ib hnub - 300 mg). Thaum lub sij hawm qhia, tus neeg mob yuav tsum nyob rau hauv lub luag haujlwm loj,
Kev daws rau cov tshuaj ua kom ncaj thiab muaj tshuaj: koob - 100 mg ntawm cov tshuaj hauv 0.9% sodium chloride tov lossis 5% kua nplaum (dextrose) tov nrog ntim ntawm 250-500 ml. Nrog kev mob loj atherosclerosis ntawm cov hlab ntsha cov hlab ntsha, kev qhia cov tshuaj rau hauv carotid leeg yog txwv.

Cov neeg mob uas mob raum tsis ua hauj lwm zoo (tsim muaj tshuaj tsawg tshaj li 30 ml ib feeb) yuav tsum tau txhaj tshuaj ntau npaum li 30-50%.

Rau kev kho mob ntawm qhov mob ntev los yog ntshav qab zib atherosclerotic, qhov tso ntshav khov yog muab rau txhua lwm hnub lossis txhua hnub.

Pentoxifylline ntsiav tshuaj noj qhov ncauj tsis tas yuav zom los yog zom (tag nrho), ntxuav nrog dej, nyiam dua tom qab noj mov.

Raws li txoj cai, enteric-coated tablets ntawm Pentoxifylline tau sau tseg hauv 2 daim pcs. 3 zaug ib hnub. Qhov nruab nrab txhua hnub koob yog 600 mg, qhov ntau tshaj yog 1200 mg. Feem ntau, tom qab 1-2 lub lis piam, ib qho tshuaj txo kom tsawg rau 1 ntsiav tshuaj, thaum qhov ntau ntawm Pentoxifylline tseem tsis hloov.

Tus kws kho mob txiav txim siab lub sijhawm ntawm kev kho kom zoo ntawm tus kheej, raws li txoj cai, nws yog 1-3 hlis.

Hauv lub raum mob raum tsis ua hauj lwm (tshem tawm creatine tsawg dua 10 ml ib feeb), yuav tsum tau txhaj tshuaj tsawg dua 2 zaug.

Pentoxifylline nyob rau hauv cov ntawv ntev npaum li cas yog feem ntau kho nrog cov zaus ntawm kev tswj hwm 2 zaug hauv ib hnub, lub sijhawm ntawm cov kev kho kom zoo yog los ntawm 2-3 lub lis piam lossis ntau dua.

Angioneuropathy (kab mob txha caj qaum, Raynaud's mob),
Peripheral circulatory ntshawv siab, uas tshwm sim los ntawm cov txheej txheem mob ntshav qab zib, mob ntshav qab zib mellitus, atherosclerosis,
Ischemic cerebrovascular kev raug mob (mob mob thiab mob ntev),
Cuam kab mob endarteritis,
Tus mob mus ntev, mob hnyav thiab subacute cov kev mob tsis ua haujlwm nyob hauv tus Retina lossis choroid,
Trophic cov ntaub so ntswg mob cuam tshuam nrog kev ua mob rau cov leeg nqaij lossis hlab ntsha me me (ua mob rau cov tawv nqaij, ua kom mob rau cov qog ntshav, mob qog nqaij hlav, mob tom qab mob ntshav qab zib),
Hnov tsis hnov lus nrog vascular etiology
Encephalopathy ntawm atherosclerotic thiab discirculatory etiology.

Lub sijhawm ntawm cov chav kawm ntawm txoj kev kho thiab qhov tshuaj txhua hnub yog txiav txim los ntawm tus kws kho mob rau txhua tus neeg mob ib tus zuj zus, uas yog nyob ntawm kev kuaj mob, qhov hnyav ntawm cov kev mob tshwm sim thiab cov yam ntxwv ntawm lub cev.

Cov ntsiav tshuaj noj tam sim ntawd tom qab noj mov, nqos tam sim, tsis txhob zom thiab ntxo, haus dej ntau los yog lwm yam kua.

Raws li cov lus qhia, cov tib neeg uas muaj 18 xyoo rov saud tau muab 200 mg ntawm cov tshuaj ib zaug peb zaug ib hnub. 400 mg ntsiav tshuaj tau xaj nyob rau hauv 1 koob tshuaj tsis pub ntau tshaj 2 zaug hauv ib hnub. Lub sijhawm kho mob raws li cov lus qhia yog 3 lub lis piam, yog tias tsim nyog, tus kws kho mob ncua sijhawm ntev lossis luv dua ntawm kev kho mob.

Pentoxifylline Nqe

Tus nqi ntawm cov tshuaj thiab nws cov analogues nyob ntawm cov khw, nyob ntawm qhov ntau thiab daim ntawv tso tawm. Qhov nruab nrab, tus nqi ntawm cov tshuaj hauv paus Pentoxifylline yog los ntawm 33 txog 72 rubles.

Tus nqi ntawm Trental nyob ntawm 157 txog 319 rubles, Agapurin tus nqi li ntawm 90 txog 137 rubles.

Tus nqi ntawm Pentoxifylline hauv 0.1 g ntsiav tshuaj yog los ntawm 85 txog 130 rubles rau pob khoom ntawm 60 daim.

Tus nqi ntawm Pentoxifylline 2% ampoules ntawm 5 ml yog 40 rubles ib 10 daim.

Tus nqi kwv yees ntawm Pentoxifylline yog: retard ntsiav tshuaj (400 mg txhua, 20 pcs.) - los ntawm 273 rubles, enteric-coated ntsiav tshuaj (100 mg, 60 pcs.) - los ntawm 62 rubles, txhaj tshuaj (20 mg / ml 10 ampoules ntawm 5 ml txhua) - los ntawm 35 rubles., Mloog zoo rau kev npaj ntawm kev daws rau txoj leeg thiab txoj leeg ntshav (20 mg / ml, 10 ampoules ntawm 5 ml) - los ntawm 36 rubles.

Tus nqi nruab nrab ntawm Pentoxifylline ntsiav tshuaj hauv Moscow cov chaw muag tshuaj yog 450-600 rubles, nyob ntawm seb qhov ntau thiab tsawg ntawm cov ntsiav tshuaj hauv pob.