Cov tshuaj muaj zog ntawm Amoxil yog amoxicillin trihydrate. Amoxicillin yog aminopenicillin hluavtaws uas muaj cov kab mob tab sis tsis rhiab ntawm cov kab mob me me uas tsim cov tshuaj penicillinase, thiab rau lwm qhov.

Amoxil muaj cov clavulanic acid, uas ua rau nws tiv taus penicillinase, txo kev tiv thaiv kev tiv thaiv kab mob rau cov neeg ua hauj lwm antimicrobial.

Kev taw qhia txog kev siv Amoxil

Raws li cov lus qhia, Amoxil tau sau tseg rau cov kab mob zoo li no:

• lub plab zom mov thiab kho tus kab mob hlwb,
• mob raum thiab mob txeeb zig
• kis kab mob ntawm cov pob txha nqaij, pob qij txha,
• cov ntaub so ntswg mos thiab tawv nqaij mob.

Amoxil muaj txiaj ntsig zoo rau kev sib kis mob tom qab kev phais mob.

Ua ke nrog clarithromycin lossis metronidazole, Amoxil yog siv rau hauv kev kho mob ntawm peptic rwj ntawm lub plab zom mov, mob plab zom mov.

Cov Yuav Tsum Muaj

• tus kheej tsis kam rau yeeb tshuaj, thiab lwm cov tshuaj tua kab mob ntawm cov tshuaj penicillin koob. Nrog rhiab heev rau cephalosporin tshuaj tua kab mob yuav tsum paub txog cov kev pheej hmoo ntawm kev ua xua khaub thuas,
• lymphocytic leukemia thiab mononucleosis mob sib kis,
• cov me nyuam qis dua 1 xyoos
• lactation lub sijhawm.

Sab sij huam

Kev ua xua nyob rau hauv daim ntawv ntawm khaus, urticaria, npaws, kev hyperemia, Stevens mob, hyperkeratosis, epidermal necrolysis, eczemathab plaub dermatitis, angioedema, vasculitis, ntshiab ntshav mob, anaphylactic poob siab.

Lub plab zom mov: tsis qab los noj mov, xeev siab, qhov ncauj qhuav, ntuav, raws plab, flatulence, mob ncauj plab, hloov pauv hauv daim siab enzyme nce mus rau, kab mob siab thiab daj.

Kev tswj hwm leeg: insomnia, ntxhov siab vim, tsis nco qab, kiv taub hau, hyperkinesismob taub hau. Nrog kev puas tsuaj rau lub raum kev ua haujlwm, tej zaum yuav muaj kev qaug dab peg.

Hematopoietic plab hnyuv siab raum:thrombocytopenia, leukopenia, hemolytic anemia, nce hauv prothrombin index.

Cov kab mob zis: interstitial jade.

Ntawm lwm yam kev cuam tshuam, superinfection yuav tshwm sim, candidiasis cov qog ua qog ua, dav dav tsis muaj zog, cuav tsis zoo rau kev txiav txim siab piam thaj hauv cov zis thiab urobilinogen.

Cov lus qhia rau kev siv Amoxil (Txujci thiab ntau npaum li cas)

Siv cov ntsiav tshuaj raws li kws kho mob tau hais tseg, tsis hais zaub mov dab tsi.

Koob tshuaj rau cov kab mob ntawm mob hnyav thiab mob hnyav:

• cov laus thiab menyuam yaus tom qab 10 xyoo - 500-750 mg 2 zaug hauv ib hnub,
• cov me nyuam los ntawm 3 txog 10 xyoo ntawm 750 mg ib hnub twg hauv 3 koob tshuaj,
• los ntawm 1 xyoos mus rau 3 250 mg ib hnub ob zaug.

Thaum muaj mob rov tshwm sim thiab mob hnyav, cov neeg laus noj 3 g ib hnub, menyuam yaus nqa 60 mg / kg ntawm qhov hnyav, muab faib ua 3 koob.

Qhov koob tshuaj txhua hnub rau cov neeg laus yog qhov ntau yog 6 g.

Lub chav kawm ntawm kev kho mob tau txuas ntxiv rau 3 hnub ntxiv tom qab kev thiav cov tsos mob. Kev kis mob ntawm me me mus rau mob hnyav tau suav nrog kev kho mob ntawm 1 lub lim tiam. Yog tias muaj tus mob beta-hemolytic streptococcus, kev kho mob tsawg kawg yog 10 hnub.

Rau kev kho mob ntawm mob tsis yooj yim gonorrhea tsa ib zaug 3 g ua ke nrog probenicide hauv qhov nyiaj ntawm 1 g.

Nrog peptic rwj rau kev tshem tawm Helicobacter pylori Cov lus qhia rau Amoxil 500 mg muab cov txheej txheem uas yuav tsum tau muab tso ua ke nrog lwm cov tshuaj:

• Amoxil 2 g ib hnub hauv ob zaug muab faib ua ke nrog clarithromycin 500 mg ib hnub ob zaug thiab omeprazole ntawm koob tshuaj 40 mg ib hnub twg.
• Amoxil 2 g ib hnub nrog metronidazole 400 mg peb zaug ib hnub thiab omeprazole 40 mg rau ib hnub.

Lub chav kawm ntawm kev kho mob yog 1 lub lis piam.

Hauv raum tsis ua haujlwm, nws yog kws kho mob coj mus rau hauv theem ntawm glomerular pom thiab qib kev tshem tawm neeg tsim tswv.

Kev sib txuam

Cov ntsiav tshuaj Amoxil thaum noj nrog tshuaj ntawm qhov ncauj tuaj yeem txo cov txiaj ntsig ntawm kev tswj kom tsis txhob muaj menyuam yaus thiab muaj feem ntau los ntshav.

Nrog rau kev siv ua ke nrog probenicide, phenylbutazone, sulfinperazone, indomethacin thiab acetylsalicylic acid kev tshem tawm ntawm Amoxil los ntawm ob lub raum ua kom qis qis dua.

Tshuaj uas muaj tus kab mob bacteriostatic ntxim (chloramphenicol, macrolides, tetracycline) nruab nrab cov nyhuv ntawm Amoxil.

Sib koom siv nrog allopurinol ua rau kom muaj kev tsis haum ntawm daim tawv nqaij.

Ib txhij sib ntsib tshuaj tiv thaiv kab mob txo qhov kev nqus ntawm Amoxil.

Ua ke nrog tshuaj thaiv tsev nce qhov feem ntau yuav los ntshav, yog li koj yuav tsum tswj qhov taw qhia lub sijhawm prothrombin.

Zawv plab txo qhov nqus ntawm cov tshuaj.

Hauv cov poj niam cev xeeb tub, cov tshuaj txo cov concentration estradiol hauv cov zis.

Cov lus qhia tshwj xeeb

Lub sijhawm ntawm kev txhim kho cov kev tsis haum rau tshuaj tua kab mob ntawm cephalosporin thiab penicillin series yuav tsum raug tshem tawm ua ntej kev kho mob.

Rov ua dua thiab siv sijhawm ntev ua rau kev txhim kho qhov kev tawm tsam thiab kev ua haujlwm siab dua.

Ntuav thiab raws plab txo qhov nqus ntawm qhov tshuaj, nyob rau hauv cov mob no nws tsis tas yuav yog cov tshuaj.

Muab kev ceev faj rau cov neeg mob nrog hawb pob thiab kev ua xua diathesis.

Noj cov tshuaj hauv cov tshuaj ntau npaum li cas ua rau muaj kev txhim kho crystalluria, yog li ntawd, rau kev tiv thaiv, nws yog qhov yuav tsum tau noj cov kua txaus.

Cov tshuaj tuaj yeem hloov cov xim ntawm txha hniav laus hauv cov menyuam yaus, yog li koj yuav tsum tau saib xyuas kev nyiam huv ntawm cov hniav thiab lub qhov ncauj.

Nrog kev ntsuas mob anaphylactic, kev ua kom lub ntsws ua pa tsis zoo, ua haujlwm epinephrineua ntawv thov antihistamines, glucocorticoids thiab cov pa.

Thaum cev xeeb tub thiab lactation

Yog tias tsim nyog, tus piv ntawm cov txiaj ntsig rau leej niam thiab qhov pheej hmoo rau tus me nyuam hauv plab yuav tsum raug ntsuas.

Qhov teratogenic nyhuv ntawm Amoxil tsis tau txheeb xyuas.

Hauv ib qho me me, cov tshuaj pom muaj nyob hauv niam mis. Kev muab tshuaj rau lactation yog ua tau, tab sis nws pom zoo kom tsis txhob pub niam mis thaum kho mob kom tsis txhob hnov ​​mob.

Kev Ntsuas Amoxil

Kev kawm txog kev tshuaj xyuas txog Amoxil, koj tuaj yeem paub tseeb tias nws yog tus nqi pheej yig thiab muaj yeeb tshuaj zoo. Ntau lub tswv yim zoo ntawm kev siv mob ntsws, mob ntsws thiab tonsillitisob leeg rau cov laus thiab cov menyuam yaus. Cov neeg mob uas tau siv cov tshuaj pom tias tau rov qab zoo sai.

Tseem muaj qee qhov kev pabcuam zoo rau mob raum thiab lwm yam pustular tawv txhab.

Qhov tsis zoo yog qhov tshwm sim hauv qee cov neeg mob ntawm kev phiv tshuaj nyob rau hauv daim ntawv ntawm daim tawv nqaij ua pa lossis mob plab.

Qhov zoo dua tseem yog tias vim muaj kev nyab xeeb, Amoxil ntsiav tshuaj raug tso cai siv rau hauv xeeb tub thiab tsev laus.

Tsuas tshuaj thiab tswj hwm

Ua raws li cov lus qhia, Amoxil yog muab kev lis ntshav thiab qhov ncauj.

Txoj kev lis ntshav (tso ntshav) kev tswj hwm yog nqa tawm hauv cov dav hlau los yog qhov dej ntws ib ntus ntawm 8-12 xuab moos. Cov tshuaj Amoxil muab tau tam sim ntawd tom qab rov ua dua ntawm cov hmoov thiab tsis tau khaws cia tom qab ntawd.

Qhov nruab nrab koob tshuaj ntawm Amoxil rau cov neeg laus yog 1000/200 mg nrog ib ncua sijhawm ntawm 8 teev. Qhov siab tshaj plaws tau tso cai tau yog 100/200 mg nrog qhov luv ntawm 6 teev.

Thaum lub sijhawm muaj kev cuam tshuam kev phais, ib koob tshuaj Amoxil 1000/200 mg tau muab rau ua ntej tshuaj loog, tom qab uas nyob hauv tib lub ntim txhua rau teev.

Hauv kev kho cov menyuam yaus, Amoxil siv rau hauv kev siv ntau npaum li no: txog 3 hlis. (Qhov hnyav txog 4 kg) yog muab ib zaug 25/5 mg rau ib hlis twg hnyav txhua 12 teev Txij li 3 hlis. txog 12 litres (Qhov hnyav tshaj 4 kg) yog muab 25/5 mg rau ib hlis twg nrog rau kev ncua sij hawm ntawm 8 teev

Kev noj cov Amoxil cov ntsiav tshuaj tsis cuam tshuam nrog kev noj mov, lawv yuav tsum nqos tag nrho. Cov ntsiav tshuaj Amoxil tau noj nrog ntu tsis pub dhau 8 teev.

Raws li cov lus qhia Amoxil cov me nyuam tau sau tseg hauv cov lus hauv qab no: 1-2 xyoos - 30 mg ib hnub twg ib phaus ntawm qhov hnyav. Los ntawm 2 mus rau 5 liv. - 125mg ib zaug. Los ntawm 5-10 litres. - 250 mg ib zaug. Nrog 10l. (nrog rau lub cev nyhav tshaj 40 kg) - 250-500 mg ib zaug. Qhov siab tshaj plaws ntawm cov menyuam yaus ntawm Amoxil hauv cov ntsiav tshuaj yog 60 mg rau ib phaus ib hnub.

Cov neeg laus Amoxil ntsiav tshuaj muab 250-500 mg. Hauv cov xwm txheej loj - 1g.

Dosage daim ntawv

250 thiab 500 mg ntsiav tshuaj

Ib ntsiav tshuaj muaj

cov tshuaj heev: amoxicillin trihydrate, hauv amoxicillin - 250 mg lossis 500 mg,

tus zam: sodium starch glycolate, povidone, calcium stearate.

Cov ntsiav tshuaj yog xim dawb nrog lub pob tw daj, pav ca-cylindrical nrog bevel thiab nqis siab tshaj.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics.

Xuas. Tom qab kev tswj hwm ntawm qhov ncauj, amoxicillin yog nqus rau hauv txoj hnyuv sai thiab yuav luag tiav (85-90%). Noj noj haus tsis cuam tshuam rau qhov nqus ntawm cov tshuaj. Tom qab noj ib koob tshuaj 500 mg, qhov kev sib xyaw ntawm amoxicillin hauv cov ntshav ntshav yog 6-11 mg / L. Qhov siab tshaj plaws ntawm cov tshuaj nquag hauv cov ntshav ntshav tau tiav tom qab 1-2 teev.

Kev xa Khoom. Kwv yees li 20% ntawm amoxicillin khi rau cov ntshav protein. Amoxicillin nkag mus rau cov hnoos qeev, mob pob txha, cov kua dej hauv qhov ncauj thiab hnoos qeev hauv tshuaj kho tau zoo. Qhov kev mloog ntxiv ntawm cov tshuaj hauv cov kua tsib ntau dua qhov nws xav hauv cov ntshav los ntawm 2-4 zaug. Amoxicillin kis tsis zoo rau cov kua dej ua kom hlab ntshav tawm, txawm li cas los xij, nrog cov mob ntawm daim npluag qhwv ntshav (piv txwv, muaj mob rau daim npluag qhwv), cov tshuaj nyob hauv cerebrospinal kua yog li 20% ntawm cov concentration hauv cov ntshav ntshav.

Kev zom zaub mov. Amoxicillin yog qee qhov kho, feem ntau nws cov khoom siv tiv thaiv kab mob tsis ua haujlwm.

Chaw Sau Ntawv. Amoxicillin ua rau mob tawm hauv lub raum. Txog 60-80% ntawm qhov kev noj tshuaj yog tshem tawm tom qab 6 teev tsis hloov. Ib nrab-lub neej ntawm cov tshuaj yog 1-1.5 teev. Nrog kev ua haujlwm tsis zoo hauv lub raum, lub sijhawm ib nrab ntawm lub zog ntawm amoxicillin nce thiab nce mus txog 8,5 teev nrog anuria.

Ib nrab-lub neej ntawm cov tshuaj tsis hloov pauv nrog lub siab ua haujlwm tsis zoo.

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog tshuaj tua kabmob ib nrab ntawm aminopenicillin broad-spectrum tshuaj tua kab mob rau kev siv ncauj. Txhawb nqa cov kev sib txuas ua ke ntawm tus kab mob cell cell. Nws muaj ntau cov teebmeem antimicrobial.

Cov kab mob me hauv qab no yog nkag siab zoo rau cov tshuaj:

- gram-zoo aerobes: Tshuaj tua kabmob (Corinebacterium diphteriae), Enterococcus faecalis, Listeria monocytogenes, Tus kab mob Streptococcus agalactiae, Streptococcus bovis, Cov kab mob Streptococcus pyogenes,

- gram-tsis zoo aerobes: Helicobacter pylori,

Kuj tsis paub ntau yam rhiab (kis tau kuj yuav ua rau cov kev kho mob nyuaj): Cib tshuaj tua kab mob spp., Enterococcus faecium, Kab mob ntsws dej liab, Streptococcus viridans, Escherichia coli, Haemophilus mob npaws, Haemophilus parainfluenzae, Moraxella catarrhalis, Proteus mirabilis, Prevotella, Fusobacterium spp.

Muaj hom kev ruaj ntseg xws li: Dab Tsi Staphylococcus aureus, Acinetobacter, Citrobacter, Enterobacter, Klebsiella, Legionella, Morganella morganii, Proteus vulgaris, Providencia, Pseudomonas, Serratia, Bacteroides fragilis, Chlamidia, Mycoplasma, Rickettsia.

Kev ntsuas rau siv

- kab mob ua pa

- lub plab zom mov (nrog rau kev sib xyaw nrog metronidazole lossis clarithromycin yog siv los kho kab mob cuam tshuam nrog Helicobacter pylori)

- kis ntawm daim tawv nqaij thiab cov nqaij mos ua kom mob los ntawm cov tshuaj lom neeg lub cev

LUS QHIA

rau kev kho mob

dіyucha rechovina: amoxicillin,

1 ntsiav tshuaj kua txiv amoxicillin trihydrate, yog tias muaj kev noj tshuaj ntau dhau ntawm amoxicillin - 250 mg lossis 500 mg,

cov lus ntxiv: sodium starch, calcium, calcium stearate.

Likarska daim ntawv. Ntsiav tshuaj

Cov tshuaj pab pawg kho mob. Penicillins ntawm ntau yam dії.

PBX code J01C A04.

Qhia. Cov kab mob sib kis, uas yog rhiab rau kev npaj ntawm cov kab mob me me, suav nrog:

- Інфекцій Lub Koom Haum Ib Leeg,

- ційнфекцій txoj kev nyom,

- ційнфекцій secchostatevo systems,

- шнфекцій шкіри і м'яких textile.

Ua ke nrog tshuaj metronidazole los yog clarithromycin, muaj kev ua tsis haum rau kev kho tshuaj ntsuab, nrog rau lub peev xwm los kho cov nyom.

mononucleosis mob sib kis, lymphocytic leukemia,

lub sij hawm ntawm lub xyoo

menyuam yaus wik rau 1 lub pob zeb.

Cov qauv tshuaj rau cov menyuam yaus thiab menyuam yaus hnub nyoog tshaj 10 xyoo nrog mob sib khuav xws li mob sib khuav xws li: 500 - 750 mg 2 zaug hauv ib dob; rau cov menyuam 3-10 xyoo - 375 mg 2 zaug rau dobo 250 mg 3 zaug toj ib Dobu, vіkom vіd 1 lub pob zeb mus rau 3 rokіv - 250 mg 2 zaug ib doba lossis 125 mg 3 zaug toj ib doba.

Thaum muaj mob nyhav, rov mob, muaj mob ntawm ib theem mob hnyav, peb tshaj cov tshuaj; muab 0.75 - 1 g 3 zaug ib dob, menyuam yaus - 60 mg / kg ntawm lub cev hnyav, thiab 2 mus rau 3 zaug ntau dua.

Qhov siab tshaj plaws dobova koob tshuaj rau doroslikh yog 6 g.

Rau Helicobacter pylori kev tshem tawm nrog lub slime ntawm lub plab duodenum AMOKSIL®, cob rau nws mus rau ib txoj hauv kev kho tsev rau kev tsim cov txheej txheem thoob ntiaj teb:

- 7 hnub ntev: amoxicillin 1 g 2 zaug Doba + clarithromycin 500 mg 2 zaug Doba + Omeprazole 40 mg 1 Abi 2 Priyomi,

- 7 hnub ntev: amoxicillin 0.75–1 g 2 zaug ib dob + metronidazole 400 mg 3 zaug ib dob + omeprazole 40 mg rau 1 lossis 2 priyomi.

Qhov siab tshaj plaws dobova koob tshuaj rau doroslikh yog 6 g.

Riven klubochkovo і fіltratsії, ml / hv

Korektsiya dozi tsis tas

Qhov tshuaj ntau ntau yog 500 mg 2 zaug ib dob

Korektsiya dozi tsis tas

15 mg / kg masi tila 2 zaug ib dob. Qhov tshuaj ntau ntau yog 500 mg 2 zaug ib dob.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntau thaum siv Amoxil® dav heev. Tus kws kho mob txiav txim qhov koob tshuaj, ntau zaus ntawm kev coj thiab lub sijhawm ntawm kev kho mob ib tus zuj zus.

Cov neeg laus thiab menyuam yausnrog lub cev hnyav dua 40 kg coj los ntawm 250 mg rau 500 mg ntawm amoxil® 3 zaug hauv ib hnub lossis txij li 500 mg txog 1000 mg 2 zaug hauv ib hnub. Txhawm rau mob ntsws, mob ntsws, thiab lwm yam mob hnyav, koj yuav tsum noj li 500 mg rau 1000 mg peb zaug ib hnub. Qhov koob tshuaj txhua hnub tuaj yeem nce ntxiv mus txog qhov ntau ntawm 6 g.

Cov menyuam yaus lub cev hnyav dua 40 kg feem ntau noj 40-90 mg / kg / hnub ntawm Amoxil® txhua hnub hauv 3 faib koob tshuaj lossis los ntawm 25 mg txog rau 45 mg / kg / hnub hauv ob zaug muab faib. Qhov tshuaj tiv thaiv ntau tshaj plaws rau me nyuam txhua hnub yog 100 mg / kg lub cev qhov hnyav (tsis ntau tshaj 3 g ib hnub).

Yog tias muaj mob me txog rau qib sib kis, siv cov tshuaj hauv 5-7 hnub. Txawm li cas los xij, rau kev kis mob los ntawm tus kab mob streptococci, lub sijhawm kho mob yuav tsum yog tsawg kawg 10 hnub.

Hauv kev kho mob ntawm cov kab mob mus ntev, cov mob sib kis hauv zos, kev kis mob nrog cov chav kawm hnyav, cov koob tshuaj ntawm lub tshuaj yuav tsum txiav txim siab coj mus rau hauv tus account kev saib xyuas ntawm tus kab mob.

Cov tshuaj yuav tsum txuas ntxiv rau 48 teev tom qab ploj ntawm cov tsos mob ntawm tus kab mob.

Amoxil® tuaj yeem siv rau hauv cov neeg mob raum tsis ua haujlwm. Hauv kev mob raum tsis ua haujlwm zoo (kev tshem tawm creatinine)